Lyme disease vaccines

ABSTRACT

The present invention relates to novel vaccines for the prevention or attenuation of Lyme disease. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of  Borrelia burgdorferi . Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the sane. The invention additionally relates to diagnostic methods for detecting,  Borrelia  gene expression.

This application claims benefit of provisional application Nos. 60/050,359 filed Jun. 20, 1997 Provisional Appl. 60/053,377 and 60/053,344 both filed Jul. 22, 1997 and Provisional Appl 60/057,483 filed Sep. 3, 1997.

FIELD OF THE INVENTION

The present invention relates to novel vaccines for the prevention or attenuation of Lyme disease. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Borrelia burgdorferi. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Borrelia gene expression.

BACKGROUND OF THE INVENTION

Lyme disease (Steere, A. C., Proc. Natl. Acad Sci. USA 91:2378-2383 (1991)), or Lyme borreliosis, is presently the most common human disease in the United States transmitted by an arthropod vector (Center for Disease Control, Morbid Mortal. Week Rep. 46(23):531-535 (1997)). Further, infection of house-hold pets, such as dogs, is a considerable problem.

While initial symptoms often include a rash at the infection point, Lyme disease is a multisystemic disorder that may include arthritic, cardiac, and neurological manifestations. While antibiotics are currently used to treat active cases of Lyme disease, B. burgdorferi persists even after prolonged antibiotic treatment. Further, B. burgdorferi can persist for years in a mammalian host in the presence of an active immune response (Straubinger. R. et al., J. Clin. Microbiol. 35:111-116 (1997); Steere, A., N. Engl. J. Med. 321:586-596 (1989)).

Lyme disease is caused by the related tick-borne-spirochetes classified as Borrelia burgdorferi sensu lato (including B. burgdorferi sensu stricto, B. afzelii, B. garinii). Although substantial progress has been made in the biochemical, ultrastructural, and genetic characterization of the organism; the spirochetal factors responsible for infectivity, immune evasion and disease pathogenesis remain largely obscure.

A number of antigenic B. burgdorferi cell surface proteins have been identified. These include the outer membrane surface proteins (Osp) OspA, OspB, OspC and OspD. OspA and OspB are encoded by tightly linked tandem genes which am transcribed as a single transcriptional unit (Brusca, J. et at, J. Bacteriol. 173:8004-8008 (1991)). The most-studied B. burgdorferi membrane protein is OspA, a lipoprotein antigen expressed by borreliae in testing ticks and the most abundant protein expressed in vitro by most borrelial isolates (Barbour, A. G., et al., Infection & Immunity 41:795-804 (1983); Howe, T. R. et al., Science 227:645 (1985)).

A number of different types of Lyme disease vaccines have been shown to induce immunological responses. Whole-cell B. burgdorferi vaccines, for example, have been shown to induce both immunological responses and protective immunity in several animal models (Reviewed in Wormser, G., Clin. Infect. Dis. 21:1267-1274 (1995)). Further, passive immunity has been demonstrated in both humans and other animals using B. burgdorferi specific antisera.

While whole-cell Lyme disease vaccines confer protective immunity in animal models, use of such vaccines presents the risk that responsive antibodies will produce an autoimmune response (Reviewed in Wormser, G., supra). This problem is at least partly the result of the production of B. burgdorferi specific antibodies which cross-react with hepatocytes and both muscle and nerve cells. B. burgdorferi heat shock proteins and the 41-kd flagellin subunit are believed to contain antigens which elicit production of these cross-reactive antibodies.

Single protein subunit vaccines for Lyme disease have also been-tested. The cell surface proteins of B. burgdorferi are potential candidates for use in such vaccines and several have been shown to elicit protective immune responses in mammals (Probert, W. et al., Vaccine 15:15-19 (1997); Fikrig, E. er al., Infect. Immun. 63: 1658-1662 (1995); Langerman S. et al., Nature 372:552-556 (1994); Fikrig, E. et al., J. Immunol. 148:2256-2260 (1992)). Experimental OspA vaccines, for example, have demonstrated efficacy in several animal models (Fikrig, E., et al., Proc. Natl. Acad. Sci. USA 89:5418-5421 (1992); Johnson, B. J., et al., Vaccine 13:1036-1094 (1996); Fikrig, E., et al., Infect. Immun. 60:657-661 (1992); Chang, Y. F., et al., Infection & Immunity 63:3543-3549 (1995)), and OspA vaccines for human use are under clinical evaluation (Keller, D., et al., J. Am. Med. Assoc. 271:1764-1768 (1994); Van Hoecke, C., et al., Vaccine 14:1620-1626 (1996)). Passive immunity is also conferred by antisera containing antibodies specific for the full-length OspA protein. Further, vaccination with plasmid DNA encoding OspA has been demonstrated to elicit protective immune responses in mice (Luke, C. et al., J. Infect. Dis. 175:91-97 (1997); Zhong, W. et al., Eur. J. Immunol. 26:2749-2757 (1996)).

Recent immunofluorescence assay observations indicate that during tick engorgement the expression of OspA by borreliae diminishes (deSilva, A. M., et al., J. Exp. Med. 183:271-275 (1996)) while expression of other proteins, exemplified by OspC, increases (Schwan, T. G., et al., Proc. Natl. Acad. Sci. USA 92:2909-2913 (1985)). By the time of transmission to hosts, spirochetes in the tick salivary glands express little or no OspA. This down-modulation of OspA appears to explain the difficulties in demonstrating immune responses to this antigen early in infection following tick bites (Kalish, R. A., et al., Infect. Immun. 63:2228-2235 (1995); Gem, L., et al., J. Infect. Dis. 167:971-975 (1993); Schiable, U. E., et al., Immunol. Lett. 36:219-226 (1993)) or following challenge with limiting doses of cultured borreliae (Schiable, U. E., et al., Immunol. Lett. 36:219-226 (1993); Barthold, S. W. and Bockenstedt, L. K., Infect. Immun. 61:4696-4702 (1993)).

Furthermore, OspA-specific antibodies are ineffective if administered after a borrelial challenge delivered by syringe (Schiable, U. E., et al., Proc. Natl. Acad. Sci. USA 87:3768-3772 (1990)) or tick bite (deSilva, A. M., et al., J. Exp. Med. 183:271-275 (1996)). To be efficacious, OspA vaccines must elicit protective levels of antibody which are maintained throughout periods of tick exposure in order to block borrelia transmission from the arthropod vector.

Vaccines in current use against other pathogens include in vivo-expressed antigens which could boost anamnestic responses upon infection, potentiate the action of immune effector cells and complement, and inhibit key virulence mechanisms. OspC is both expressed during infection (Montgomery, R. R., et al., J. Exp. Med. 183:261-269 (1996)) and a target for protective immunity (Gilmore, R. D., et al., Infect Immun. 64:2234-2239 (1996); Probert, W. S. and LeFebvre, R. B., Infect. Immun. 62: 1920-1926 (1994); Preac-Mursic, V., et. al., Infection 20:342-349 (1992)), but mice immunized with this protein were only protected against challenge with the homologous borrelial isolate (Probert, W. S., et al., J. Infect Dis. 175:400-405 (1997)). Identification of in vivo-expressed, and broadly protective, antigens of B. burgdorferi has remained elusive.

SUMMARY OF THE INVENTION

The present invention provides isolated nucleic acid molecules comprising polynucleotides encoding the B. burgdorferi peptides having the amino acid sequences shown in Table 1. Thus, one aspect of the invention provides isolated nucleic acid molecules comprising polynucleotides having a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence encoding any of the amino acid sequences of the full-length polypeptides shown in Table 1; (b) a nucleotide sequence encoding any of the amino acid sequences of the full-length polypeptides shown in Table 1 but minus the N-terminal methionine residue, if present; (c) a nucleotide sequence encoding any of the amino acid sequences of the truncated polypeptides shown in Table 1; and (d) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), or (c) above.

Further embodiments of the invention include isolated nucleic acid molecules that comprise a polynucleotide having a nucleotide sequence at least 90% identical, and more preferably at least 95%, 96%, 97%, 98% or 99% identical, to any of the nucleotide sequences in (a), (b), (c), or (d) above, or a polynucleotide which hybridizes under stringent hybridization conditions to a polynucleotide in (a), (b), (c), or (d) above. This polynucleotide which hybridizes does not hybridize under stringent hybridization conditions to a polynucleotide having a nucleotide sequence consisting of only A residues or of only T residues. Additional nucleic acid embodiments of the invention relate to isolated nucleic acid molecules comprising polynucleotides which encode the amino acid sequences of epitope-bearing portions of a B. burgdorferi polypeptide having an amino acid sequence in (a), (b), or (c) above.

The present invention also relates to recombinant vectors, which include the isolated nucleic acid molecules of the present invention, and to host cells containing the recombinant vectors, as well as to methods of making such vectors and host cells and for using these vectors for the production of B. burgdorferi polypeptides or peptides by recombinant techniques.

The invention further provides isolated B. burgdorferi polypeptides having an amino acid sequence selected from the group consisting of: (a) an amino acid sequence of any of the full-length polypeptides shown in Table 1; (b) an amino acid sequence of any of the full-length polypeptides shown in Table 1 but minus the N-terminal methionine residue, if present; (c) an amino acid sequence of any of the truncated polypeptides shown in Table 1; and (d) an amino acid sequence of an epitope-bearing portion of any one of the polypeptides of (a), (b), or (c).

The polypeptides of the present invention also include polypeptides having an amino acid sequence with at least 70% similarity, and more preferably at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% similarity to those described in (a), (b), (c), or (d) above, as well as polypeptides having an amino acid sequence at least 70% identical, more preferably at least 75% identical, and still more preferably 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% identical to those above; as well as isolated nucleic acid molecules encoding such polypeptides.

The present invention further provides a vaccine, preferably a multi-component vaccine comprising one or more of the B. burgdorferi polypeptides shown in Table 1, or fragments thereof, together with a pharmaceutically acceptable diluent, carrier, or excipient, wherein the B. burgdorferi polypeptide(s) are present in an amount effective to elicit an immune response to members of the Borrelia genus in an animal. The B. burgdorferi polypeptides of the present invention may further be combined with one or more immunogens of one or more other borrelial or non-borrelial organisms to produce a multi-component vaccine intended to elicit an immunological response against members of the Borrelia genus and, optionally, one or more non borrelial organisms.

The vaccines of the present invention can be administered in a DNA form, e.g., “naked” DNA, wherein the DNA encodes one or more borrelial polypeptides and, optionally, one or more polypeptides of a non-borrelial organism. The DNA encoding one or more polypeptides may be constructed such that these polypeptides are expressed fusion proteins.

The vaccines of the present invention may also be administered as a component of a genetically engineered organism. Thus, a genetically engineered organism which expresses one or more B. burgdorferi polypeptides may be administered to an animal. For example, such a genetically engineered organism may contain one or more B. burgdorferi polypeptides of the present invention intracellularly, on its cell surface, or in its periplasmic space. Further, such a genetically engineered organism may secrete one or more B. burgdorferi polypeptides.

The vaccines of the present invention may be co-administered to an animal with an immune system modulator (e.g., CD86 and GM-CSF).

The invention also provides a method of inducing an immunological response in an animal to one or more members of the Borrelia genus, e.g., B. burgdorferi sensu stricto, B. afzelii, and B. garinii, comprising administering to the animal a vaccine as described above.

The invention further provides a method of inducing a protective immune response in an animal, sufficient to prevent or attenuate an infection by members of the Borrelia genus, comprising administering to the animal a composition comprising one or more of the polypeptides shown in Table 1, or fragments thereof. Further, these polypeptides, or fragments thereof, may be conjugated to another immunogen and/or administered in admixture with an adjuvant.

The invention further relates to antibodies elicited in an animal by the administration of one or more B. burgdorferi polypeptides of the present invention.

The invention also provides diagnostic methods for detecting the expression of genes of members of the Borrelia genus in an animal. One such method involves assaying for the expression of a gene encoding Borrelia peptides in a sample from an animal. This expression may be assayed either directly (e.g., by assaying polypeptide levels using antibodies elicited in response to amino acid sequences shown in Table 1) or indirectly (e.g., by assaying for antibodies having specificity for amino acid sequences shown in Table 1). An example of such a method involves the use of the polymerase chain reaction (PCR) to amplify and detect Borrelia nucleic acid sequences.

The present invention also relates to nucleic acid probes having all or part of a nucleotide sequence shown in Table 1 which are capable of hybridizing under stringent conditions to Borrelia nucleic acids. The invention further relates to a method of detecting one or more Borrelia nucleic acids in a biological sample obtained from an animal, said one or more nucleic acids encoding Borrelia polypeptides, comprising:

-   -   a) contacting the sample with one or more of the above-described         nucleic acid probes, under conditions such that hybridization         occurs, and     -   b) detecting hybridization of said one or more probes to the         Borrelia nucleic acid present in the biological sample.

DETAILED DESCRIPTION

The present invention relates to recombinant antigenic B. burgdorferi polypeptides and fragments thereof. The invention also relates to methods for using these polypeptides to produce immunological responses and to confer immunological protection to disease caused by members of the genus Borrelia. The invention further relates to nucleic acid sequences which encode antigenic B. burgdorferi polypeptides and to methods for detecting Borrelia nucleic acids and polypeptides in biological samples. The invention also relates to Borrelia specific antibodies and methods for detecting such antibodies produced in a host animal.

Definitions

The following definitions are provided to clarify the subject matter which the inventors consider to be the present invention.

As used herein, the phrase “pathogenic agent” means an agent which causes a disease state or affliction in an animal. Included within this definition, for examples, are bacteria, protozoans, fungi, viruses and metazoan parasites which either produce a disease state or render an animal infected with such an organism susceptible to a disease state (e.g., a secondary infection). Further included are species and strains of the genus Borrelia which produce disease states in animals.

As used herein, the term “organism” means any living biological system, including viruses, regardless of whether it is a pathogenic agent.

As used herein, the term “Borrelia” means any species or strain of bacteria which is members of the genus Borrelia. Included with this definition are Borrelia burgdorferi sensu lato (including B. burgdorferi sensu stricto, B. afzelii, B. garinii), B. andersonii, B. anserina, B. japonica, B. coriaceae, and other members of the genus Borrelia regardless of whether they are known pathogenic agents.

As used herein, the phrase “one or more B. burgdorferi polypeptides of the present invention” means the amino acid sequence of one or more of the B. burgdorferi polypeptides disclosed in Table 1. These polypeptides may be expressed as fusion proteins wherein the B. burgdorferi polypeptides of the present invention are linked to additional amino acid sequences which may be of borrelial or non-borrelial origin. This phrase further includes fragments of the B. burgdorferi polypeptides of the present invention.

As used herein, the phrase “full-length amino acid sequence” and “full-length polypeptide” refer to an amino acid sequence or polypeptide encoded by a full-length open reading frame (ORF). An ORF may be defined as a nucleotide sequence bounded by stop codons which encodes a putative polypeptide. An ORF may also be defined as a nucleotide sequence within a stop codon bounded sequence which contains an initiation codon (e.g., a methionine or valine codon) on the 5′ end and a stop codon on the 3′ end.

As used herein, the phrase “truncated amino acid sequence” and “truncated polypeptide” refer to a sub-sequence of a full-length amino acid sequence or polypeptide. Several criteria may also be used to define the truncated amino acid sequence or polypeptide. For example, a truncated polypeptide may-be defined as a mature polypeptide (e.g., a polypeptide which lacks a leader sequence). A truncated polypeptide may also be defined as an amino acid sequence which is a portion of a longer sequence that has been selected for ease of expression in a heterologous system but retains regions which render the polypeptide useful for use in vaccines (e.g., antigenic regions which are expected to elicit a protective immune response).

Additional definitions are provided throughout the specification.

Explanation of Table 1

Table 1 lists B. burgdorferi nucleotide and amino acid sequences of the present invention. The nomenclature used therein is as follows:

-   -   “nt” refers to nucleotide sequences;     -   “aa” refers to amino acid sequences;     -   “f” refers to full-length nucleotide or amino acid sequences;         and     -   “t” refers to truncated nucleotide or amino acid sequences.

Thus, for example, the designation “f101.aa” refers to the full-length amino acid sequence of B. burgdorferi polypeptide number 010. Further, “f101.nt” refers to the full-length nucleotide sequence encoding the full-length amino acid sequence of B. burgdorferi polypeptide number 101.

Explanation of Table 2

Table 2 lists accession numbers for the closest matching sequences between the polypeptides of the present invention and those available through GeniBank and GeneSeq databases. These reference numbers are the database entry numbers commonly used by those of skill in the art, who will be familiar with their denominations. The descriptions of the nomenclature for GenBank are available from the National Center for Biotechnology Information. Column 1 lists the gene or ORF of the present invention Column 2 lists the accession number of a “match” gene sequence in Genbank or GeneSeq databases. Column 3 lists the description of the “match” gene sequence. Columns 4 and 5 are the high score and smallest sum probability, respectively, calculated by BLAST. Polypeptides of the present invention that do not share significant identity/similarity with any polypeptide sequences of GenBank and GeneSeq are not represented in Table 2. Polypeptides of the present invention that share significant identity/similarity with more than one of the polypeptides of GenBank and GeneSeq are represented more than once.

Explanation of Table 3.

The B. burgdorferi polypeptides of the present invention may include one or more conservative amino acid substitutions from natural mutations or human manipulation as indicated in Table 3. Changes are preferably of a minor nature, such as conservative amino acid substitutions that do not significantly affect the folding or activity of the protein. Residues from the following groups, as indicated in Table 3, may be substituted for one another: Aromatic, Hydrophobic, Polar, Basic, Acidic, and Small.

Explanation of Table 4

Table 4 lists residues comprising antigenic epitopes of antigenic epitope-bearing fragments present in each of the full length B. burgdorferi polypeptides described in Table 1 as predicted by the inventors using the algorithm of Jameson and Wolf, (1988) Comp. Appl. Biosci. 4:181-186. The Jameson-Wolf antigenic analysis was performed using the computer program PROTEAN (Version 3.11 for the Power MacIntosh, DNASTAR, Inc., 1228 South Park Street Madison, Wis.). B. burgdorferi polypeptide shown in Table 1 may one or more antigenic epitopes comprising residues described in Table 4. It will be appreciated that depending on the analytical criteria used to predict antigenic determinants, the exact address of the determinant may vary slightly. The residues and locations shown described in Table 4 correspond to the amino acid sequences for each full length gene sequence shown in Table 1 and in the Sequence Listing. Polypeptides of the present invention that do not have antigenic epitopes recognized by the Jameson-Wolf algorithm are not represented in Table 2.

Selection of Nucleic Acid Sequences Encoding Antigenic B. burgdorferi Polypeptides

The present invention provides a select number of ORFs from those presented in the fragments of the Borrelia burgdorferi genome which may prove useful for the generation of a protective immune response. The sequenced B. burgdorferi genomic DNA was obtained from a sub-cultured isolate of ATCC Deposit No. 35210. The sub-cultured isolate was deposited on Aug. 8, 1997 at the American Type Culture Collection, 12301 Park Lawn Drive, Rockville, Md. 20852, and given accession number 202012.

Some ORFs contained in the subset of fragments of the B. burgdorferi genome disclosed herein were derived through the use of a number of screening criteria detailed below. The ORFs are generally bounded at the amino terminus by a methionine residue and at the carboxy terminus by a stop codon.

Many of the selected sequences do not consist of complete ORFs. Although a polypeptide representing a complete ORF may be the closest approximation of a protein native to an organism, it is not always preferred to express a complete ORF in a heterologous system. It may be challenging to express and purify a highly hydrophobic protein by common laboratory methods. Some of the polypeptide vaccine candidates described herein have been modified slightly to simplify the production of recombinant protein. For example, nucleotide sequences which encode highly hydrophobic domains, such as those found at the amino terminal signal sequence, have been excluded from some constructs used for in vitro expression of the polypeptides. Furthermore, any highly hydrophobic amino acid sequences occurring at the carboxy terminus have also been excluded from the recombinant expression constructs. Thus, in one embodiment, a polypeptide which represents a truncated or modified ORF may be used as an antigen.

While numerous methods are known in the art for selecting potentially immunogenic polypeptides, many of the ORFs disclosed herein were selected on the basis of screening all theoretical Borrelia burgdorferi ORFs for several aspects of potential immunogenicity. One set of selection criteria are as follows:

1. Type I signal sequence: An amino terminal type I signal sequence generally directs a nascent protein across the plasma and outer membranes to the exterior of the bacterial cell. Experimental evidence obtained from studies with Escherichia coli suggests that the typical type I signal sequence consists of the following biochemical and physical attributes (Izard, J. W. and Kendall, D. A. Mol. Microbiol. 13:765-773 (1994)). The length of the type I signal sequence is approximately 15 to 25 primarily hydrophobic amino acid residues with a net positive charge in the extreme amino terminus. In addition, the central region of the signal sequence adopts an alpha-helical conformation in a hydrophobic environment. Finally, the region surrounding the actual site of cleavage is ideally six residues long, with small side-chain amino acids in the −1 and −3 positions.

2. Type IV signal sequence: The type IV signal sequence is an example of the several types of functional signal sequences which exist in addition to the type I signal sequence detailed above. Although functionally related, the type IV signal sequence possesses a unique set of biochemical and physical attributes (Strom, M. S. and Lory, S., J. Bacteriol. 174:7345-7351 (1992)). These are typically six to eight amino acids with a net basic charge followed by an additional sixteen to thirty primarily hydrophobic residues. The cleavage site of a type IV signal sequence is typically after the initial six to eight amino acids at the extreme amino terminus. In addition, type IV signal sequences generally contain a phenylalanine residue at the +1 site relative to the cleavage site.

3. Lipoprotein: Studies of the cleavage sites of twenty-six bacterial lipoprotein precursors has allowed the definition of a consensus amino acid sequence for lipoprotein cleavage. Nearly three-fourths of the bacterial lipoprotein precursors examined contained the sequence L-(A,S)-(G,A)-C at positions −3 to +1, relative to the point of cleavage (Hayashi, S. and Wu, H. C., J. Bioenerg. Biomembr. 22:451-471 (1990)).

4. LPXTG motif. It has been experimentally determined that most anchored proteins found on the surface of gram-positive bacteria possess a highly conserved carboxy terminal sequence. More than fifty such proteins from organisms such as S. pyogenes, S. mutans, B. burgdorferi, S. pneumoniae, and others, have been identified based on their extracellular location and carboxy terminal amino acid sequence (Fischetti, V. A., ASM News 62:405-410 (1996)). The conserved region consists of six charged amino acids at the extreme carboxy terminus coupled to 15-20 hydrophobic amino acids presumed to function as a transmembrane domain. Immediately adjacent to the transmembrane domain is a six amino acid sequence conserved in nearly all proteins examined. The amino acid sequence of this region is L-P-X-T-G-X, where X is any amino acid.

An algorithm for selecting antigenic and immunogenic Borrelia burgdorferi polypeptides including the foregoing criteria was developed. The algorithm is similar to that described in U.S. patent application. Ser. No. 08/781,986, filed Jan. 3, 1997, which is fully incorporated by reference herein. Use of the algorithm by the inventors to select immunologically useful Borrelia burgdorferi polypeptides resulted in the selection of a number of the disclosed ORFs. Polypeptides comprising the polypeptides identified in this group may be produced by techniques standard in the art and as further described herein.

Nucleic Acid Molecules

The present invention provides isolated nucleic acid molecules comprising polynucleotides encoding the B. burgdorferi polypeptides having the amino acid sequences shown in Table 1, which were determined by sequencing the genome of B. burgdorferi deposited as ATCC deposit no. 202012 and selected as putative immunogens.

Unless otherwise indicated, all nucleotide sequences determined by sequencing a DNA molecule herein were determined using an automated DNA sequencer (such as the Model 373 from Applied Biosystems, Inc.), and all amino acid sequences of polypeptides encoded by DNA molecules determined herein were predicted by translation of DNA sequences determined as above. Therefore, as is known in the art for any DNA sequence determined by this automated approach, any nucleotide sequence determined herein may contain some errors. Nucleotide sequences determined by automation are typically at least about 90% identical, more typically at least about 95% to at least about 99.9% identical to the actual nucleotide sequence of the sequenced DNA molecule. The actual sequence can be more precisely determined by other approaches including manual DNA sequencing methods well known in the art. As is also known in the art, a single insertion or deletion in a determined nucleotide sequence compared to the actual sequence will cause a frame shift in translation of the nucleotide sequence such that the predicted amino acid sequence encoded by a determined nucleotide sequence will be completely different from the amino acid sequence actually encoded by the sequenced DNA molecule, beginning at the point of such an insertion or deletion.

Unless otherwise indicated, each “nucleotide sequence” set forth herein is presented as a sequence of deoxyribonucleotides (abbreviated A, G, C and T). However, by “nucleotide sequence” of a nucleic acid molecule or polynucleotide is intended, for a DNA molecule or polynucleotide, a sequence of deoxyribonucleotides; and for an RNA molecule or polynucleotide, the corresponding sequence of ribonucleotides (A, G, C and U), where each thymidine deoxyribonucleotide (T) in the specified deoxyribonucleotide sequence is replaced by the ribonucleotide uridine (U). For instance, reference to an RNA molecule having a sequence of Table 1 set forth using deoxyribonucleotide abbreviations is intended to indicate an RNA molecule having a sequence in which each deoxyribonucleotide A, G or C of Table 1 has been replaced by the corresponding ribonucleotide A, G or C; and each deoxyribonucleotide T has been replaced by a ribonucleotide U.

Nucleic acid molecules of the present invention may be in the form of RNA, such as mRNA, or in the form of DNA, including, for instance, cDNA and genomic DNA obtained by cloning or produced synthetically. The DNA may be double-stranded or single-stranded. Single-stranded DNA or RNA may be the coding strand, also known as the sense strand, or it may be the non-coding strand, also referred to as the anti-sense strand.

By “isolated” nucleic acid molecule(s) is intended a nucleic acid molecule, DNA or RNA, which has been removed from its native environment. For example, recombinant DNA molecules contained in a vector are considered isolated for the purposes of the present invention. Further examples of isolated DNA molecules include recombinant DNA molecules maintained in heterologous host cells or purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically.

In addition, isolated nucleic acid molecules of the invention include DNA molecules which comprise a sequence substantially different from those described above but which, due to the degeneracy of the genetic code, still encode a B. burgdorferi polypeptides and peptides of the present invention (e.g. polypeptides of Table 1). That is, all possible DNA sequences that encode the B. burgdorferi polypeptides of the present invention. This includes the genetic code and species-specific codon preferences known in the art. Thus, it would be routine for one skilled in the art to generate the degenerate variants described above, for instance, to optimize codon expression for a particular host (e.g., change codons in the bacteria mRNA to those preferred by a mammalian or other bacterial host such as E. coli).

The invention further provides isolated nucleic acid molecules having the nucleotide sequence shown in Table 1 or a nucleic acid molecule having a sequence complementary to one of the above sequences. Such isolated molecules, particularly DNA molecules, are useful as probes for gene mapping and for identifying B. burgdorferi in a biological sample, for instance, by PCR, Southern blot, Northern blot, or other form of hybridization analysis.

The present invention is further directed to nucleic acid molecules encoding portions or fragments of the nucleotide sequences-described herein. Fragments include portions of the nucleotide sequences of Table 1 at least 10 contiguous nucleotides in length selected from any two integers, one of which representing a 5′ nucleotide position and a second of which representing a nucleotide position, where the first nucleotide for each nucleotide sequence in Table 1 is position 1. That is, every combination of a 5′ and 3′ nucleotide position that a fragment at least contiguous nucleotides in length could occupy is included in the invention. “At least” means a fragment may be 10 contiguous nucleotide bases in length or any integer between 10 and the length of an entire nucleotide sequence of Table 1 minus 1. Therefore, included in the invention are contiguous fragments specified by any 5′ and 3′ nucleotide base positions of a nucleotide sequences of Table 1 wherein the contiguous fragment is any integer between 10 and the length of an entire nucleotide sequence minus 1.

Further, the invention includes polynucleotides comprising fragments specified by size, in nucleotides, rather than by nucleotide positions. The invention includes any fragment size, in contiguous nucleotides, selected from integers between 10 and the length of an entire nucleotide sequence minus 1. Preferred sizes of contiguous nucleotide fragments include 20 nucleotides, 30 nucleotides, 40 nucleotides, 50 nucleotides. Other preferred sizes of contiguous nucleotide fragments, which may be useful as diagnostic probes and primers, include fragments 50-300 nucleotides in length which include, as discussed above, fragment sizes representing each integer between 50-300. Larger fragments are also useful according to the present invention corresponding to most, if not all, of the nucleotide sequences shown in Table 1 or of the B. burgdorferi nucleotide sequences of the plasimd clones listed in Table 1. The preferred sizes are, of course, meant to exemplify not limit the present invention as all size fragments, representing any integer between 10 and the length of an entire nucleotide sequence minus 1, are included in the invention. Additional preferred nucleic acid fragments of the present invention include nucleic acid molecules encoding epitope-bearing portions of B. burgdorferi polypeptides identified in Table 4.

The present invention also provides for the exclusion of any fragment, specified by 5′ and 3′ base positions or by size in nucleotide bases as described above for any nucleotide sequence of Table 1 or the plasimd clones listed in Table 1. Any number of fragments of nucleotide sequences in Table 1 or the plasimd clones listed in Table 1, specified by 5′ and 3′ base positions or by size in nucleotides, as described above, may be excluded from the present invention.

Preferred nucleic acid fragments of the present invention also include nucleic acid molecules encoding epitope-bearing portions of the B. burgdorferi polypeptides shown in Table 1. Such nucleic acid fragments of the present invention include, for example, nucleic acid molecules encoding polypeptide fragments comprising from about the amino terminal residue to about the carboxy terminal residue of each fragment shown in Table 4. The above referred to polypeptide fragments are antigenic regions of particular B. burgdorferi polypeptides shown in Table 1. Methods for determining other such epitope-bearing portions for the remaining polypeptides described in Table 1 are well known in the art and are described in detail below.

In another aspect, the invention provides isolated nucleic acid molecules comprising polynucleotides which hybridize under stringent hybridization conditions to a portion of a polynucleotide in a nucleic acid molecule of the invention described above, for instance, a nucleic acid sequence shown in Table 1. By “stringent hybridization conditions” is intended overnight incubation at 42 C in a solution comprising: 50% formamide, 5× SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7;6), 5× Denhardt's solution, 10% dextran sulfate, and 20 g/m denatured, sheared salmon sperm DNA, followed by washing the filters in 0.1× SSC at about 65 C.

By polynucleotides which hybridize to a “portion” of a polynucleotide is intended polynucleotides (either DNA or RNA) which hybridize to at least about 15 nucleotides (nt), and more preferably at least about 20 nt, still more preferably at least about 30 nt, and even more preferably about 30-70 nt of the reference polynucleotide. These are useful as diagnostic probes and primers as discussed above and in more detail below.

Of course, polynucleotides hybridizing to a larger portion of the reference polynucleotide, for instance, a portion 50-100 nt in length, or even to the entire length of the reference polynucleotide, are also useful as probes according to the present invention, as are polynucleotides corresponding to most, if not all, of a nucleotide sequence as shown in Table 1. By a portion of a polynucleotide of “at least 20 nt in length,” for example, is intended 20 or more contiguous nucleotides from the nucleotide sequence of the reference polynucleotide (e.g., a nucleotide sequences as shown in Table 1). As noted above, such portions are useful diagnostically either as probes according to conventional DNA hybridization techniques or as primers for amplification of a target sequence by PCR as described, for instance, in Molecular Cloning, A Laboratory Manual, 2nd. edition, Sambrook, J., Fritsch, E. F. and Maniatis, T., eds., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1989), the entire disclosure of which is hereby incorporated herein by reference.

Since nucleic acid sequences encoding the B. burgdorferi polypeptides of the present invention are provided in Table 1, generating polynucleotides which hybridize to portions of these sequences would be routine to the skilled artisan. For example, the hybridizing polynucleotides of the present invention could be generated synthetically according to known techniques.

As indicated, nucleic acid molecules of the present invention which encode B. burgdorferi polypeptides of the present invention may include, but are not limited to those encoding the amino acid sequences of the polypeptides by themselves; and additional coding sequences which code for additional amino acids, such as those which provide additional functionalities. Thus, the sequences encoding these polypeptides may be fused to a marker sequence, such as a sequence encoding a peptide which facilitates purification of the fused polypeptide. In certain preferred embodiments of this aspect of the invention, the marker amino acid sequence is a hexa-histidine peptide, such as the tag provided in a pQE vector (Qiagen, Inc.), among others, many of which are commercially available. As described in Gentz et al., Proc. Natl. Acad. Sci. USA 86:821-824 (1989), for instance, hexa-histidine provides for convenient purification of the resulting fusion protein.

Thus, the present invention also includes genetic fusions wherein the B. burgdorferi nucleic acid sequences coding sequences provided in Table 1 are linked to additional nucleic acid sequences to produce fusion proteins. These fusion proteins may include epitopes of borrelial or non-borrelial origin designed to produce proteins having enhanced immunogenicity. Further, the fusion proteins of the present invention may contain antigenic determinants known to provide helper T-cell stimulation, peptides encoding sites for post-translational modifications which enhance immunogenicity (e.g., acylation), peptides which facilitate purification (e.g. histidine “tag”), or amino acid sequences which target the fusion protein to a desired location (e.g., a heterologous leader sequence). For instance, hexa-histidine provides for convenient purification of the fusion protein. See Gentz et al. (1989) Proc. Natl. Acad. Sci. 86:821-24. The “HA” tag is another peptide useful for purification which corresponds to an epitope derived from the influenza hemagglutinin protein. See Wilson et al. (1984) Cell 37:767. As discussed below, other such fusion proteins include the B. burgdorferi polypeptides of the present invention fused to Fc at the N- or C-terminus.

Post-translational modification of the full-length B. burgdorferi OspA protein expressed in E. coli is believed to increase the immunogenicity of this protein. Erdile, L: et al., Infect Immun. 61:81-90 (1993). B. burgdorferi OspA when expressed in E. coli, for example, is post-translationally modified in at least two ways. First, a signal peptide is cleaved; second, lipid moieties are attached. The presence of these lipid moieties is believed to confer enhanced immunogenicity and results in the elicitation of a strong protective immunological response.

Variant and Mutant Polynucleotides

The present invention thus includes nucleic acid molecules and sequences which encode fusion proteins comprising one or more B. burgdorferi polypeptides of the present invention fused to an amino acid sequence which allows for post-translational modification to enhance immunogenicity. This post-translational modification may occur either in vitro or when the fusion protein is expressed in vivo in a host cell. An example of such a modification is the introduction of an amino acid sequence which results in the attachment of a lipid moiety. Such a lipid moiety attachment site of OspA, which is lipidated upon expression in E. coli, has been identified. Bouchon, B. et al., Anal. Biochem. 246:52-61 (1997).

Thus, as indicated above, the present invention includes genetic fusions wherein a B. burgdorferi nucleic acid sequence provided in Table 1 is linked to a nucleotide sequence encoding another amino acid sequence. These other amino acid sequences may be of borrelial origin (e.g., another sequence selected from Table 1) or non-borrelial origin. An example of such a fusion protein is reported in Fikrig, E. et al., Science. 250:553-556 (1990) where an OspA-glutathione-S-transferase fusion protein was produced and shown to elicit protective immunity against Lyme disease in immune competent mice.

The present invention further relates to variants of the nucleic acid molecules of the present invention, which encode portions, analogs or derivatives of the B. burgdorferi polypeptides shown in Table 1. Variants may occur naturally, such as a natural allelic variant. By an “allelic variant” is intended one of several alternate forms of a gene occupying a given locus on a chromosome of an organism. Genes II, Lewin, B., ed., John Wiley & Sons, New York (1985). Non-naturally occurring variants may be produced using art-known mutagenesis techniques.

Such variants include those produced by nucleotide substitutions, deletions or additions. The substitutions, deletions or additions may involve one or more nucleotides. These variants may be altered in coding regions, non-coding regions, or both. Alterations in the coding regions may produce conservative or non-conservative amino acid substitutions, deletions or additions. Especially preferred among these are silent substitutions, additions and deletions, which do not alter the properties and activities of the B. burgdorferi polypeptides disclosed herein or portions thereof. Also especially preferred in this regard are conservative substitutions.

The present application is further directed to nucleic acid molecules at least 90%, 95%, 96%, 97%, 98% or 99% identical to a nucleic acid sequence shown in Table 1. The above nucleic acid sequences are included irrespective of whether they encode a polypeptide having B. burgdorferi activity. This is because even where a particular nucleic acid molecule does not encode a polypeptide having B. burgdorferi activity, one of skill in the art would still know how to use the nucleic acid molecule, for instance, as a hybridization probe. Uses of the nucleic acid molecules of the present invention that do not encode a polypeptide having B. burgdorferi activity include, inter alia, isolating an B. burgdorferi gene or allelic variants thereof from a DNA library, and detecting B. burgdorferi mRNA expression samples, environmental samples, suspected of containing B. burgdorferi by Northern Blot analysis.

Embodiments of the invention include isolated nucleic acid molecules comprising a polynucleotide having a nucleotide sequence at least 90% identical, and more preferably at least 95%, 96%, 97%, 98% or 99% identical to (a) a nucleotide sequence encoding any of the amino acid sequences of the full-length polypeptides shown in Table 1; (b) a nucleotide sequence encoding any of the amino acid sequences of the full-length polypeptides shown in Table 1 but minus the N-terminal methionine residue, if present; (c) a nucleotide sequence encoding any of the amino acid sequences of the truncated polypeptides shown in Table 1; and (d) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), or (c) above.

Preferred, are nucleic acid molecules having sequences at least 90%, 95%, 96%, 97%, 98% or 99% identical to the nucleic acid sequence shown in Table 1, which do, in fact, encode a polypeptide having B. burgdorferi protein activity By “a polypeptide having B. burgdorferi activity” is intended polypeptides exhibiting activity similar, but not necessarily identical, to an activity of the B. burgdorferi protein of the invention, as measured in a particular biological assay suitable for measuring activity of the specified protein.

Due to the degeneracy of the genetic code, one of ordinary skill in the art will immediately recognize that a large number of the nucleic acid molecules having a sequence at least 90%, 95%, 96%, 97%, 98%, or 99% identical to the nucleic acid sequences shown in Table 1 will encode a polypeptide having B. burgdorferi protein activity. In fact, since degenerate variants of these nucleotide sequences all encode the same polypeptide, this will be clear to the skilled artisan even without performing the above described comparison assay. It will be further recognized in the art that, for such nucleic acid molecules that are not degenerate variants, a reasonable number will also encode a polypeptide having B. burgdorferi protein activity: This is because the skilled artisan is fully aware of amino acid substitutions that are either less likely or not likely to significantly effect protein function (e.g., replacing one aliphatic amino acid with a second aliphatic amino acid), as further described below.

The biological activity or function of the polypeptides of the present invention are expected to be similar or identical to polypeptides from other bacteria that share a high degree of structural identity/similarity. Tables 2 lists accession numbers and descriptions for the closest matching sequences of polypeptides available through Genbank and Derwent databases. It is therefore expected that the biological activity or function of the polypeptides of the present invention will be similar or identical to those polypeptides from other bacterial genuses, species, or strains listed in Table 2.

By a polynucleotide having a nucleotide sequence at least, for example, 95% “identical” to a reference nucleotide sequence of the present invention, it is intended that the nucleotide sequence of the polynucleotide is identical to the reference sequence except that the polynucleotide sequence may include up to five point mutations per each 100 nucleotides of the reference nucleotide sequence encoding the B. burgdorferi polypeptide. In other words, to obtain a polynucleotide having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% (5 of 100) of the nucleotides in the reference sequence may be deleted, inserted, or substituted with another nucleotide. The query sequence may be an entire sequence shown in Table. 1, the ORF (open reading frame), or any fragment specified as described herein.

As a practical matter, whether any particular nucleic acid molecule or polypeptide is at least 90%, 95%, 96%, 97%, 98% or 99% identical to a nucleotide sequence of the presence invention can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB computer program based on the algorithm of Brutlag et al. See Brutlag et al. (1990) Comp. App. Biosci. 6:237-245. In a sequence alignment the query and subject sequences are both DNA sequences. An RNA sequence can be compared by first converting U's to T's. The result of said global sequence alignment is in percent identity. Preferred parameters used in a FASTDB alignment of DNA sequences to calculate percent identity are: Matrix=Unitary, k-tuple=4, Mismatch Penalty=1, Joining Penalty=30, Randomization Group Length=0, Cutoff Score=1, Gap Penalty=5, Gap Size Penalty 0.05, Window Size=500 or the lenght of the subject nucleotide sequence, whichever is shorter.

If the subject sequence is shorter than the query sequence because of 5′ or 3′ deletions, not because of internal deletions, a manual correction must be made to the results. This is because the FASTDB program does not account for 5′ and 3′ truncations of the subject sequence when calculating percent identity. For subject sequences truncated at the 5′ or 3′ ends, relative to the query sequence, the percent identity is corrected by calculating the number of bases of the query sequence that are 5′ and 3′ of the subject sequence, which are not matched/aligned, as a percent of the total bases of the query sequence. Whether a nucleotide is matched/aligned is determined by results of the FASTDB sequence alignment. This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score. This corrected score is what is used for the purposes of the present invention. Only nucleotides outside the 5′ and 3′ nucleotides of the subject sequence, as displayed by the FASTDB alignment, which are not matched/aligned with the query sequence, are calculated for the purposes of manually adjusting the percent identity score.

For example, a 90 nucleotide subject sequence is aligned to a 100 nucleotide query sequence to determine percent identity. The deletions occur at the 5′ end of the subject sequence and therefore, the FASTDB alignment does not show a matched/alignment of the first 10′ nucleotides at 5′ end. The 10 unpaired nucleotides represent 10% of the sequence (number of nucleotides at the 5′ and 3′ ends not matched/total number of nucleotides in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 nucleotides were perfectly matched the final percent identity would be 90%. In another example, a 90 nucleotide subject sequence is compared with a 100 nucleotide query sequence. This time the deletions are internal deletions so that there are no nucleotides on the 5′ or 3′ of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only nucleotides 5′ and 3′ of the subject sequence which are not matched/aligned with the query sequence are manually corrected for. No other manual corrections are to made for the purposes of the present invention.

Vectors and Host Cells

The present invention also relates to vectors which include the isolated DNA molecules of the present invention, host cells which are genetically engineered with the recombinant vectors, and the production of B. burgdorferi polypeptides or fragments thereof by recombinant techniques.

Recombinant constructs may be introduced into host cells using well known techniques such as infection, transduction, transfection transvection, electroporation and transformation. The vector may be for example, a phage, plasmid, viral or retroviral vector. Retroviral vectors may be replication competent or replication defective. In the latter case, viral propagation generally will occur only in complementing host cells.

The polynucleotides may be joined to a vector containing a selectable marker for propagation in a host. Generally, a plasmid vector is introduced in a precipitate, such as a calcium phosphate precipitate, or in a complex with a charged lipid. If the vector is a virus, it may be packaged in vitro using an appropriate packaging cell line and then transduced into host cells.

Preferred are vectors-comprising cis-acting control regions to the polynucleotide of interest. Appropriate trans-acting factors may be supplied by the host, supplied by a complementing vector or supplied by the vector itself upon introduction into the host.

In certain preferred embodiments in this regard, the vectors provide for specific expression, which may be inducible and/or cell type-specific. Particularly preferred among such vectors are those inducible by environmental factors that are easy to manipulate, such as temperature and nutrient additives.

Expression vectors useful in the present invention include chromosomal- , episomal- and virus-derived vectors, e.g., vectors derived from bacterial plasmids, bacteriophage, yeast episomes, yeast chromosomal elements, viruses such as baculoviruses, papova viruses, vaccinia viruses, adenoviruses, fowl pox viruses, pseudorabies viruses and retroviruses, and vectors derived from combinations thereof, such as cosmids and phagemids.

The DNA insert should be operatively linked to an appropriate promoter, such as the phage lambda PL promoter, the E. coli lac, trp and tac promoters, the SV40 early and late promoters and promoters of retroviral LTRs, to name a few. Other suitable promoters will be known to the skilled artisan. The expression constructs will further contain sites for transcription initiation, termination and, in the transcribed region, a ribosome binding site for translation. The coding portion of the mature transcripts expressed by the constructs will preferably include a translation initiating site at the beginning and a termination codon (UAA, UGA or UAG) appropriately positioned at the end of the polypeptide to be translated.

As indicated, the expression vectors will preferably include at least one selectable marker. Such markers include dihydrofolate reductase or neomycin resistance for eukaryotic cell culture and tetracycline or ampicillin resistance genes for culturing in E. coli and other bacteria. Representative examples of appropriate hosts include, but are not limited to, bacterial cells, such as E. coli, Streptomyces and Salmonella typhimurium cells; fungal cells, such as yeast cells; insect cells such as Drosophila S2 and Spodoptera Sf9 cells; animal cells such as CHO, COS and Bowes melanoma cells; and plant cells. Appropriate culture mediums and conditions for the above-described host cells are known in the art.

Among vectors preferred for use in bacteria include pQE70, pQE60 and pQE-9, available from Qiagen; pBS vectors, Phagescript vectors, Bluescript vectors, pNH8A, pNH16a, pNH18A, pNH46A available from Stratagene; pET series of vectors available from Novagen; and ptrc99a, pKK223-3, pKK233-3, pDR540, pRIT5 available from Pharmacia. Among preferred eukaryotic vectors are pWLNEO, pSV2CAT, pOG44, pXT1 and pSG available from Stratagene; and pSVK3, pBPV, pMSG and pSVL available from Pharmacia. Other suitable vectors will be readily apparent to the skilled artisan.

Among known bacterial promoters suitable for use in the present invention include the E. coli lacI and lacZ promoters, the T3 and T7 promoters, the gpt promoter, the lambda PR and PL promoters and the trp promoter. Suitable eukaryotic promoters include the CMV immediate early promoter, the HSV thymidine kinase promoter, the early and late SV40 promoters, the promoters of retroviral LTRs, such as those of the Rous sarcoma virus (RSV), and metallothionein promoters, such as the mouse metallothionein-I promoter.

Introduction of the construct into the host cell can be effected by calcium phosphate transfection, DEAE-dextran mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection or other methods. Such methods are described in many standard laboratory manuals, such as Davis et al., Basic Methods In Molecular Biology (1986).

Transcription of DNA encoding the polypeptides of the present invention by higher eukaryotes may be increased by inserting an enhancer sequence into the vector. Enhancers are cis-acting elements of DNA, usually about from 10 to 300 bp that act to increase transcriptional activity of a promoter in a given host cell-type. Examples of enhancers include the SV40 enhancer, which is located on the late side of the replication origin at bp 100 to 270, the cytomegalovirus early promoter enhancer, the polyoma enhancer on the late side of the replication origin, and adenovirus enhancers.

For secretion of the translated polypeptide into the lumen of the endoplasmic reticulum, into the periplasmic space or into the extracellular environment, appropriate secretion signals may be incorporated into the expressed polypeptide. The signals may be endogenous to the polypeptide or they may be heterologous signals.

The polypeptide may be expressed in a modified form, such as a fusion protein, and may include not only secretion signals, but also additional heterologous functional regions. For instance, a region of additional amino acids, particularly charged amino acids, may be added to the N-terminus of the polypeptide to improve stability and persistence in the host cell, during purification, or during subsequent handling and storage. Also, peptide moieties may be added to the polypeptide to facilitate purification. Such regions may be removed prior to final preparation of the polypeptide. The addition of peptide moieties to polypeptides to engender secretion or excretion, to improve stability and to facilitate purification, among others, are familiar and routine techniques in the art. A preferred fusion protein comprises a heterologous region from immunoglobulin that is useful to solubilize proteins. For example, EP-A-O 464 533 (Canadian counterpart 2045869) discloses fusion proteins comprising various portions of constant region of immunoglobin molecules together with another human protein or part thereof. In many cases, the Fc part in a fusion protein is thoroughly advantageous for use in therapy and diagnosis and thus results, for example, in improved pharmacokinetic properties (EP-A 0232 262). On the other hand, for some uses it would be desirable to be able to delete the Fc part after the fusion protein has been expressed, detected and purified in the advantageous manner described. This is the case when Fc portion proves to be a hindrance to use in therapy and diagnosis, for example when the fusion protein is to be used as antigen for immunizations. In drug discovery, for example, human proteins, such as, hIL5-receptor has been fused with Fc portions for the purpose of high-throughput screening assays to identify antagonists of hIL-5. See Bennett, D. et al., J. Molec. Recogn. 8:52-58 (1995) and Johanson, K. et al., J. Biol. Chem. 270 (16):9459-9471 (1995).

The B. burgdorferi polypeptides can be recovered and purified from recombinant cell cultures by well-known methods including ammonium sulfate or ethanol precipitation, acid extraction, anion or cation exchange chromatography, phosphocellulose chromatography, hydrophobic interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography and high performance liquid chromatography (“HPLC”) is employed for purification. Polypeptides of the present invention include naturally purified products, products of chemical synthetic procedures, and products produced by recombinant techniques from a prokaryotic or eukaryotic host, including, for example, bacterial, yeast, higher plant, insect and mammalian cells.

Polypeptides and Fragments

The invention further provides isolated polypeptides having the amino acid sequences in Table 1, and peptides or polypeptides comprising portions of the above polypeptides. The terms “peptide” and “oligopeptide” are considered synonymous (as is commonly recognized) and each term can be used interchangeably as the context requires to indicate a chain of at least to amino acids coupled by peptidyl linkages. The word “polypeptide” is used herein for chains containing more than ten amino acid residues. All oligopeptide and polypeptide formulas or sequences herein are written from left to right and in the direction from amino terminus to carboxy terminus.

As discussed in detail below, immunization using B. burgdorferi sensu stricto isolate B31 decorin-binding protein elicits the production of antiserum which confers passive immunity against Borrelia species and strains which express divergent forms of this protein. Cassatt, D. et al., Protection of Borrelia burgdorferi Infection by Antibodies to Decorin-binding Protein, in VACCINES97, Cold Spring Harbor Press 1997), pages 191-195. Thus, some amino acid sequences of the B. burgdorferi polypeptides shown in Table 1 can be varied without significantly effecting the antigenicity of the polypeptides. If such differences in sequence are contemplated, it should be remembered that there will be critical areas on the polypeptide which determine antigenicity. In general, it is possible to replace residues which do not form part of an antigenic epitope without significantly effecting the antigenicity of a polypeptide.

Variant and Mutant Polypeptides

To improve or alter the characteristics of B. burgdorferi polypeptides of the present invention, protein engineering may be employed. Recombinant DNA technology known to those skilled in the art can be used to create novel mutant proteins or muteins including single or multiple amino acid substitutions, deletions, additions, or fusion proteins. Such modified polypeptides can show, e.g., enhanced activity or increased stability. In addition, they may be purified in higher yields and show better solubility than the corresponding natural polypeptide, at least under certain purification and storage conditions.

N-Terminal and C-Terminal Deletion Mutants

It is known in the art that one or more amino acids may be deleted from the N-terminus or C-terminus without substantial loss of biological function. For instance, Ron et al. J. Biol. Chem., 268:2984-2988 (1993), reported modified KGF proteins that had heparin binding activity even if 3, 8, or 27 N-terminal amino acid residues were missing. Accordingly, the present invention provides polypeptides having one or more residues deleted from the amino terminus of the amino acid sequence of the B. burgdorferi polypeptides shown in Table 1, and polynucleotides encoding such polypeptides.

Similarly, many examples of biologically functional C-terminal deletion muteins are known. For instance, Interferon gamma shows up to ten times higher activities by deleting 8-10 amino acid residues from the carboxy terminus of the protein See, e.g., Dobeli, et al. (1988) J. Biotechnology 7:199-216. Accordingly, the present invention provides polypeptides having one or more residues from the carboxy terminus of the amino acid sequence of the B. burgdorferi polypeptides shown in Table 1. The invention also provides polypeptides having one or more amino acids deleted from both the amino and the carboxyl termini as described below.

The present invention is further directed to polynucleotide encoding portions or fragments of the amino acid sequences described herein as well as to portions or fragments of the isolated amino acid sequences described herein. Fragments include portions of the amino acid sequences of Table 1, are at least 5 contiguous amino acid in length, are selected from any two integers, one of which representing a N-terminal position. The initiation codon of the polypeptides of the present inventions position 1. Every combination of a N-terminal and C-terminal position that a fragment at least 5 contiguous amino acid residues in length could occupy, on any given amino acid sequence of Table 1 is included in the invention. At least means a fragment may be 5 contiguous amino acid residues in length or any integer between 5 and the number of residues in a full length amino acid sequence minus 1. Therefore, included in the invention are contiguous fragments specified by any N-terminal and C-terminal positions of amino acid sequence set forth in Table 1 wherein the contiguous fragment is any integer between 5 and the number of residues in a full length sequence minus 1.

Further, the invention includes polypeptides comprising fragments specified by size, in amino acid residues, rather than by N-terminal and C-terminal positions. The invention includes any fragment size, in contiguous amino acid residues, selected from integers between 5 and the number of residues in a full length sequence minus 1. Preferred sizes of contiguous polypeptide fragments include about 5 amino acid residues, about 10 amino acid residues, about 20 amino acid residues, about 30 amino acid residues, about 40 amino acid residues, about 50 amino acid residues, about 100 amino acid residues, about 200 amino acid residues, about 300 amino acid residues, and about 400 amino acid residues. The preferred sizes are, of course, meant to exemplify, not limit, the present invention as all size fragments representing any integer between 5 and the number of residues in a full length sequence minus 1 are included in the invention. The to present invention also provides for the exclusion of any fragments specified by N-terminal and C-terminal positions or by size in amino acid residues as described above. Any number of fragments specified by N-terminal and C-terminal positions or by size in amino acid residues as described above may be excluded.

The above fragments need not be active since they would be useful, for example, in immunoassays, in epitope mapping, epitope tagging, to generate antibodies to a particular portion of the protein, as vaccines, and as molecular weight markers.

Other Mutants

In addition to N- and C-terminal deletion forms of the protein discussed above, it also will be recognized by one of ordinary skill in the art that some amino acid sequences of the B. burgdorferi polypeptide can be varied without significant effect of the structure or function of the protein. If such differences in sequence are contemplated, it should be remembered that there will be critical areas on the protein which determine activity.

Thus, the invention further includes variations of the B. burgdorferi polypeptides which show substantial B. burgdorferi polypeptide activity or which include regions of B. burgdorferi protein such as the protein portions discussed below. Such mutants include deletions, insertions, inversions, repeats, and type substitutions selected according to general rules known in the art so as to have little effect on activity. For example, guidance concerning how to make phenotypic ally silent amino acid substitutions is provided. There are two main approaches for studying the tolerance of an amino acid sequence to change. See, Bowie, J. U. et al. (1990), Science 247:1306-1310. The first method relies on the process of evolution, in which mutations are either accepted or rejected by natural selection. The second approach uses genetic engineering to introduce amino acid changes at specific positions of a cloned gene and selections or screens to identify sequences that maintain functionality.

These studies have revealed that proteins are surprisingly tolerant of amino acid substitutions. The studies indicate which amino acid changes are likely to be permissive at a certain position of the protein. For example, most buried amino acid residues require nonpolar side chains, whereas few features of surface side chains are generally conserved. Other such phenotypically silent substitutions are described by Bowie et al. (supra) and the references cited therein. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu and Ile; interchange of the hydroxyl residues Ser and Thr, exchange of the acidic residues Asp and Glu, substitution between the, amide residues Asn and Gln, exchange of the basic residues Lys and Arg and replacements among the aromatic residues Phe, Tyr.

Thus, the fragment; derivative, analog, or homolog of the polypeptide of Table 1, or that encoded by the plaimds listed in Table 1, may be: (i) one in which one or more of the amino acid residues are substituted with a conserved or non-conserved amino acid residue (preferably a conserved amino acid residue) and such substituted amino acid residue may or may not be one encoded by the genetic code: or (ii) one in which one or more of the amino acid residues includes a substituent group: or (iii) one in which the B. burgdorferi polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (for example, polyethylene glycol): or (iv) one in which the additional amino acids are fused to the above form of the polypeptide, such as an IgG Fc fusion region peptide or leader or secretory sequence or a sequence which is employed for purification of the above form of the polypeptide or a proprotein sequence. Such fragments, derivatives and analogs are deemed to be within the scope of those skilled in the art from the teachings herein.

Thus, the B. burgdorferi polypeptides of the present invention may include one or more amino acid substitutions, deletions, or additions, either from natural mutations or human manipulation. As indicated, changes are preferably of a minor nature, such as conservative amino acid substitutions that do not significantly affect the folding or activity of the protein (see Table 3).

Amino acids in the B. burgdorferi proteins of the present invention that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis. See, e.g., Cunningham et al. (1989) Science 244:1081-1085. The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity using assays appropriate for measuring the function of the particular protein.

Of special interest are substitutions of charged amino acids with other charged or neutral amino acids which may produce proteins with highly desirable improved characteristics, such as less aggregation. Aggregation may not only reduce activity but also be problematic when preparing pharmaceutical formulations, because aggregates can be immunogenic. See, e.g., Pinckard et al., (1967) Clin. Exp. Immunol. 2:331-340; Robbins, et al., (1987) Diabetes 36:838-845; Cleland, et al., (1993) Crit. Rev. Therapeutic Drug Carrier Systems 10:307-377.

The polypeptides of the present invention are preferably provided in an isolated form, and preferably are substantially purified. A recombinantly produced version of the B. burgdorferi polypeptide can be substantially purified by the one-step method described by Smith et al. (1988) Gene 67:31-40. Polypeptides of the invention also can be purified from natural or recombinant sources using antibodies directed against the polypeptides of the invention in methods which are well known in the art of protein purification.

The invention further provides for isolated B. burgdorferi polypeptides comprising an amino acid sequence selected from the group consisting of: (a) the amino acid sequence of a full-length B. burgdorferi polypeptide having the complete amino acid sequence shown in Table 1 (b) the amino acid sequence of a full-length B. burgdorferi polypeptide having the complete amino acid sequence shown in Table 1 excepting the N-terminal methionine; (c) the complete amino acid sequence encoded by the plasmids listed in Table 1; and (d) the complete amino-acid sequence excepting the N-terminal methionine encoded by the plasmids listed in Table 1. The polypeptides of the present invention also include polypeptides having an amino acid sequence at least 80% identical, more preferably at least 90% identical, and still more preferably 95%, 96%, 97%, 98% or 99% identical to those described in (a), (b), (c), and (d) above.

Further polypeptides of the present invention include polypeptides which have at least 90% similarity, more preferably at least 95% similarity, and still more preferably at least 96%, 97%, 98% or 99% similarity to those described above.

A further embodiment of the invention relates to a polypeptide which comprises the amino acid sequence of a B. burgdorferi polypeptide having an amino acid sequence which contains at least one conservative amino acid substitution, but not more than 50 conservative amino acid substitutions, not more than 40 conservative amino acid substitutions, not more than 30 conservative amino acid substitutions, and not more than 20 conservative amino acid substitutions. Also provided are polypeptides which comprise the amino acid sequence of a B. burgdorferi polypeptide, having at least one, but not more than 10, 9, 8, 7, 6, 5, 4, 3, 2 or 1 conservative amino acid substitutions.

By a polypeptide having an amino acid sequence at least, for example, 95% “identical” to a query amino acid sequence of the present invention, it is intended that the amino acid sequence of the subject polypeptide is identical to the query sequence except that the subject polypeptide sequence may include up to five amino acid alterations per each 100 amino acids of the query amino acid sequence. In other words, to obtain a polypeptide having an amino acid sequence at least 95% identical to a query amino acid sequence, up to 5% of the amino acid residues in the subject sequence may be inserted, deleted, (indels) or substituted with another amino acid. These alterations of the reference sequence may occur at the amino or carboxy terminal positions of the reference amino acid sequence or anywhere between those terminal positions, interspersed either individually among residues in the reference sequence or in one or more contiguous groups within the reference sequence.

As a practical matter, whether any particular polypeptide is at least 90%, 95%, 96%, 97%, 98% or 99% identical to, for instance, the amino acid sequences shown in Table 1 or to the amino acid sequence encoded by the plaimds listed in Table 1 can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB computer program based on the algorithm of Brutlag et al., (1990) Comp. App. Biosci. 6:237-245. In a sequence alignment the query and subject sequences are both amino acid sequences. The result of said global sequence alignment is in percent identity. Preferred parameters used in a FASTDB amino acid alignment are: Matrix=PAM 0, k-tuple=2, Mismatch Penalty=1, Joining Penalty=20, Randomization Group Length=0, Cutoff Score=1, Window Size=sequence length, Gap Penalty=5, Gap Size Penalty=0.05, Window Size=500 or the length of the subject amino acid sequence, whichever is shorter.

If the subject sequence is shorter than the query sequence due to N- or C-terminal deletions, not because of internal deletions, the results, in percent identity, must be manually corrected. This is because the FASTDB program does not account for N- and C-terminal truncations of the subject sequence when calculating global percent identity. For subject sequences truncated at the N- and C-termini, relative to the query sequence, the percent identity is corrected by calculating the number of residues of the query sequence that are N- and C-terminal of the subject sequence, which are not matched/aligned with a corresponding subject residue, as a percent of the total bases of the query sequence. Whether a residue is matched/aligned is determined by results of the FASTDB sequence alignment. This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score. This final percent identity score is what is used for the purposes of the present invention. Only residues to the N- and C-termini of the subject sequence, which are not matched/aligned with the query sequence, are considered for the purposes of manually adjusting the percent identity score. That is, only query amino acid residues outside the farthest N- and C-terminal residues of the subject sequence.

For example, a 90 amino acid residue subject sequence is aligned with a 100 residue query sequence to determine percent identity. The deletion occurs at the N-terminus of the subject sequence and therefore, the FASTDB alignment does not match/align with the first 10 residues at the N-terminus. The 10 unpaired residues represent 10% of the sequence (number of residues at the N- and C-termini not matched/total number of residues in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 residues were perfectly matched the final percent identity would be 90%. In another example, a 90 residue subject sequence is compared with a 100 residue query sequence. This time the deletions are internal so there are no residues at the N- or C-termini of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only residue positions outside the N- and C-terminal ends of the subject sequence, as displayed in the FASTDB alignment, which are not matched/aligned with the query sequence are manually corrected. No other manual corrections are to made for the purposes of the present invention.

The above polypeptide sequences are included irrespective of whether they have their normal biological activity. This is because even where a particular polypeptide molecule does not have biological activity, one of skill in the art would still know how to use the polypeptide, for instance, as a vaccine or to generate antibodies. Other uses of the polypeptides of the present invention that do not have B. burgdorferi activity include, inter alia, as epitope tags, in epitope mapping, and as molecular weight markers on SDS-PAGE gels or on molecular sieve gel filtration columns using methods known to those of skill in the art.

As described below, the polypeptides of the present invention can also be used to raise polyclonal and monoclonal antibodies, which are useful in assays for detecting B. burgdorferi protein expression or as agonists and antagonists capable of enhancing or inhibiting B. burgdorferi protein function. Further, such polypeptides can be used in the yeast two-hybrid system to “capture” B. burgdorferi protein binding proteins which are also candidate agonists and antagonists according to the present invention. See, e.g., Fields et al. (1989) Nature 340:245-246.

Epitope-Bearing Portions

In another aspect, the invention provides peptides and polypeptides comprising epitope-bearing portions of the B. burgdorferi polypeptides of the present invention. These epitopes are immunogenic or antigenic epitopes of the polypeptides of the present invention. An “immunogenic epitope” is defined as a part of a protein that elicits an antibody response when the whole protein or polypeptide is the immunogen. These immunogenic epitopes are believed to be confined to a few loci on the molecule. On the other hand, a region of a protein molecule to which an antibody can bind is defined as an “antigenic determinant” or “antigenic epitope.” The number of immunogenic epitopes of a protein generally is less than the number of antigenic epitopes. See, e.g., Geysen, et al. (1983) Proc. Natl. Acad. Sci. USA 81:3998-4002. Predicted antigenic epitopes are shown in Table 4, below. It is pointed out that Table 4 only lists amino acid residues comprising epitopes predicted to have the highest degree of antigenicity. The polypeptides not listed in Table 4 and portions of polypeptides not listed in Table 4 are not considered non-antigenic. This is because they may still be antigenic in vivo but merely not recognized as such by the particular algorithm used. Thus, Table 4 lists the amino acid residues comprising preferred antigenic epitopes but not a complete list. Amino acid residues comprising other anigenic epitopes may be determined by algorithms similar to the Jameson-Wolf analysis or by in vivo testing for an antigenic response using the methods described herein or those known in the art.

As to the selection of peptides or polypeptides bearing an antigenic epitope (i.e., that contain a region of a protein molecule to which an antibody can bind), it is well known in that art that relatively short synthetic peptides that mimic part of a protein sequence are routinely capable of eliciting an antiserum that reacts with the partially mimicked protein. See, e.g., Sutcliffe, et al., (1983) Science 219:660-666. Peptides capable of eliciting protein-reactive sera are frequently represented in the primary sequence of a protein, can be characterized by a set of simple chemical rules, and are confined neither to immunodominant regions of intact proteins (i.e. immunogenic epitopes) nor to the amino or carboxyl terminals. Peptides that are extremely hydrophobic and those of six or fewer residues generally are ineffective at inducing antibodies that bind to the mimicked protein; longer, peptides, especially those containing proline residues, usually are effective. See, Sutcliffe, et al., supra, p. 661. For instance, 18 of 20 peptides designed according to these guidelines, containing 8-39 residues covering 75% of the sequence of the influenza virus hemagglutinin HA1 polypeptide chain, induced antibodies that reacted with the HA1 protein or intact virus; and 12/12 peptides from the MuLV polymerase and 18/18 from the rabies glycoprotein induced antibodies that precipitated the respective proteins.

Antigenic epitope-bearing peptides and polypeptides of the invention are therefore useful to raise antibodies, including monoclonal antibodies, that bind specifically to a polypeptide of the invention. Thus, a high proportion of hybridomas obtained by fusion of spleen cells from donors immunized with an antigen epitope-bearing peptide generally secrete antibody reactive with the native protein. See Sutcliffe, et al., supra, p. 663. The antibodies raised by antigenic epitope-bearing peptides or polypeptides are useful to detect the mimicked protein, and antibodies to different peptides may be used for tracking the fate of various regions of a protein precursor which undergoes post-translational processing. The peptides and anti-peptide antibodies may be used in a variety of qualitative or quantitative assays for the mimicked protein, for instance in competition assays since it has been shown that even short peptides (e.g., about 9 amino acids) can bind and displace the larger peptides in immunoprecipitation assays. See, e.g., Wilson, et al., (1984) Cell 37:767-778. The anti-peptide antibodies of the invention also are useful for purification of the mimicked protein, for instance, by adsorption chromatography using methods known in the art.

Antigenic epitope-bearing peptides and polypeptides of the invention designed according to the above guidelines preferably contain a sequence of at least seven, more preferably at least nine and most preferably between about 10 to about 50 amino acids (i.e. any integer between 7 and 50) contained within the amino acid sequence of a polypeptide of the invention. However, peptides or polypeptides comprising a larger portion of an amino acid sequence of a polypeptide of the invention, containing about 50 to about 100 amino acids, or any length up to and including the entire amino acid sequence of a polypeptide of the invention, also are considered epitope-bearing peptides or polypeptides of the invention and also are useful for inducing antibodies that react with the mimicked protein. Preferably, the amino acid sequence of the epitope-bearing peptide is selected to provide substantial solubility in aqueous solvents (i.e., the sequence includes relatively hydrophilic residues and highly hydrophobic sequences are preferably avoided); and sequences containing proline residues are particularly preferred.

Non-limiting examples of antigenic polypeptides or peptides that can be used to generate an Borrelia-specific immune response or antibodies include portions of the amino acid sequences identified in Table 1. More specifically, Table 4 discloses a list of non-limiting residues that are involved in the antigenicity of the epitope-bearing fragments of the present invention. Therefore, the present inventions provides for isolatd and purified antigenic epitope-bearing fragments of the polypeptides of the present invention comprising a peptide sequences of Table 4. The antigenic epitope-bearing fragments comprising a peptide sequence of Table 4 preferably contain a sequence of at least seven, more preferably at least nine and most preferably between about 10 to about 50 amino acids (i.e. any integer between 7 and 50) of a polypeptide of the present invention. That is, included in the present invention are antigenic polypeptides between the integers of 7 and 50 amino acid in length comprising one or more of the sequences of Table 4. Therefore, in most cases, the polypeptides of Table 4 make up only a portion of the antigenic polypeptide. All combinations of sequences between the integers of 7 and 50 amino acid in length comprising one or more of the sequences of Table 4 are included. The antigenic epitope-bearing fragements may be specified by either the number of contiguous amino acid residues or by specific N-terminal and C-terminal positions as described above for the polypeptide fragments of the present invention, wherein the initiation codon is residue 1. Any number of the described antigenic epitope-bearing fragments of the present invention may also be excluded from the present invention in the same manner.

The epitope-bearing peptides and polypeptides of the invention may be produced by any conventional means for making peptides or polypeptides including recombinant means using nucleic acid molecules of the invention. For instance, an epitope-bearing amino acid sequence of the present invention may be fused to a larger polypeptide which acts as a carrier during recombinant production and purification, as well as during immunization to produce anti-peptide antibodies. Epitope-bearing peptides also may be synthesized using known methods of chemical synthesis. For instance, Houghten has described a simple method for synthesis of large numbers of peptides, such as 10-20 mg of 248 different 13 residue peptides representing single amino acid variants of a segment of the HA1 polypeptide which were prepared and characterized (by ELISA-type binding studies) in less than four weeks (Houghten, R. A. Proc. Natl. Acad. Sci. USA 82:5131-5135 (1985)). This “Simultaneous Multiple Peptide Synthesis (SMPS)” process is further described in U.S. Pat. No. 4,631,211 to Houghten and coworkers (1986). In this procedure the individual resins for the solid-phase synthesis of various peptides are contained in separate solvent-permeable packets, enabling the optimal use of the many identical repetitive steps involved in solid-phase methods. A completely manual procedure allows 500-1000 or more syntheses to be conducted simultaneously (Houghten et al. (1985) Proc. Natl. Acad. Sci. 82:5131-5135 at 5134.

Epitope-bearing peptides and polypeptides of the invention are used to induce antibodies according to methods well known in the art. See, e.g., Sutcliffe, et al., supra; Wilson, et al., supra; and Bittle, et al. (1985) J. Gen. Virol. 66:2347-2354. Generally, animals may be immunized with free peptide; however, anti-peptide antibody titer may be boosted by coupling of the peptide to a macromolecular carrier, such as keyhole limpet hemacyanin (KLH) or tetanus toxoid. For instance, peptides containing cysteine may be coupled to carrier using a linker such as m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS), while other peptides may be coupled to carrier using a more general linking agent such as glutaraldehyde. Animals such as rabbits, rats and mice are immunized with either free or carrier-coupled peptides, for instance, by intraperitoneal and/or intradermal injection of emulsions containing about 100 μg peptide or carrier protein and Freund's adjuvant. Several booster injections may be needed, for instance, at intervals of about two weeks, to provide a useful titer of anti-peptide antibody which can be detected, for example, by ELISA assay using free peptide adsorbed to a solid surface. The titer of anti-peptide antibodies in serum from an immunized animal may be increased by selection of anti-peptide antibodies, for instance, by adsorption to the peptide on a solid support and elution of the selected antibodies according to methods well known in the art.

Immunogenic epitope-bearing peptides of the invention, i.e., those parts of a protein that elicit an antibody response when the whole protein is the immunogen, are identified according to methods known in the art. For instance, Geysen, et al., supra, discloses a procedure for rapid concurrent synthesis on solid supports of hundreds of peptides of sufficient purity to react in an ELISA. Interaction of synthesized peptides with antibodies is then easily detected without removing them from the support. In this manner a peptide bearing an immunogenic epitope of a desired protein may be identified routinely by one of ordinary skill in the art. For instance, the immunologically important epitope in the coat protein of foot-and-mouth disease virus was located by Geysen et al. supra with a resolution of seven amino acids by synthesis of an overlapping set of all 208 possible hexapeptides covering the entire 213 amino acid sequence of the protein. Then, a complete replacement set of peptides in which all 20 amino acids were substituted in turn at every position within the epitope were synthesized, and the particular amino acids conferring specificity for the reaction with antibody were determined. Thus, peptide analogs of the epitope-bearing peptides of the invention can be made routinely by this method. U.S. Pat. No. 4,708,781 to Geysen (1987) further describes this method of identifying a peptide bearing an immunogenic epitope of a desired protein.

Further still, U.S. Pat. No. 5,194,392, to Geysen (1990), describes a general method of detecting or determining the sequence of monomers (amino acids or other compounds) which is a topological equivalent of the epitope (i.e., a “mimotope”) which is complementary to a particular paratope (antigen binding site) of an antibody of interest. More generally, U.S. Pat. No. 4,433,092, also to Geysen (1989), describes a method of detecting or determining a sequence of monomers which is a topographical equivalent of a ligand which is complementary to the ligand binding site of a particular receptor of interest. Similarly, U.S. Pat. No. 5,480,971 to Houghten, R. A. et al. (1996) discloses linear C₁-C₇-alkyl peralkylated oligopeptides and sets and libraries of such peptides, as well as methods for using such oligopeptide sets and libraries for determining the sequence of a peralkylated oligopeptide that preferentially binds to an acceptor molecule of interest. Thus, non-peptide analogs of the epitope-bearing peptides of the invention also can be made routinely by these methods. The entire disclosure of each document-cited in this section on “Polypeptides and Fragments” is hereby incorporated herein by reference.

As one of skill in the art will appreciate, the polypeptides of the present invention and the epitope-bearing fragments thereof described above can be combined with parts of the constant domain of immunoglobulins (IgG), resulting in chimeric polypeptides. These fusion proteins facilitate purification and show an increased half-life in vivo. This has been shown, e.g., for chimeric proteins consisting of the first two domains of the human CD4-polypeptide and various domains of the constant regions of the heavy or light chains of mammalian immunoglobulins. (EPA 0,394,827; Traunecker et al. (1988) Nature 331:84-86. Fusion proteins that have a disulfide-linked dimeric structure due to the IgG part can also be more efficient in binding and neutralizing other molecules than a monomeric B. burgdorferi polypeptide or fragment thereof alone. See Fountoulakis et al. (1995) J. Biochem. 270:3958-3964. Nucleic acids encoding the above epitopes of B. burgdorferi polypeptides can also be recombined with a gene of interest as an epitope tag to aid in detection and purification of the expressed polypeptide.

Antibodies

B. burgdorferi protein-specific antibodies for use in the present invention can be raised against the intact B. burgdorferi protein or an antigenic polypeptide fragment thereof, which may be presented together with a carrier protein, such as an albumin, to an animal system (such as rabbit or mouse) or, if it is long enough (at least-about 25 amino acids), without a carrier.

As used herein, the term “antibody” (Ab) or “monoclonal antibody” (Mab) is meant to include intact molecules, single chain whole antibodies, and antibody fragments. Antibody fragments of the present invention include Fab and F(ab′)2 and other fragments including single-chain Fvs (scFv) and disulfide-linked Fvs (sdFv). Also included in the present invention are chimeric and humanized monoclonal antibodies and polyclonal antibodies specific for the polypeptides of the present invention. The antibodies of the present invention may be prepared by any of a variety of methods. For example, cells expressing a polypeptide of the present invention or an antigenic fragment thereof can be administered to an animal in order to induce the production of sera containing polyclonal antibodies. For example, a preparation of B. burgdorferi polypeptide or fragment thereof is prepared and purified to render it substantially free of natural contaminants. Such a preparation is then introduced into an animal in order to produce polyclonal antisera of greater specific activity.

In a preferred method, the antibodies of the present invention are monoclonal antibodies or binding fragments thereof. Such monoclonal antibodies can be prepared using hybridoma technology. See, e.g., Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988); Hammerling, et al., in: MONOCLONAL ANTIBODIES AND T-CELL HYBRIDOMAS 563-681 (Elsevier, N.Y., 1981). Fab and F(ab′)2 fragments may be produced by proteolytic cleavage, using enzymes such as papain (to produce Fab fragments) or pepsin (to produce F(ab′)2 fragments). Alternatively, B. burgdorferi polypeptide-binding fragments, chimeric, and humanized antibodies can be produced through the application of recombinant DNA technology or through synthetic chemistry using methods known in the art.

Alternatively, additional antibodies capable of binding to the polypeptide antigen of the present invention may be produced in a two-step procedure through the use of anti-idiotypic antibodies. Such a method makes use of the fact that antibodies are themselves antigens, and that, therefore, it is possible to obtain an antibody which binds to a second antibody. In accordance with this method, B. burgdorferi polypeptide-specific antibodies are used to immunize an animal, preferably a mouse. The splenocytes of such an animal are then used to produce hybridoma cells, and the hybridoma cells are screened to identify clones which produce an antibody whose ability to bind to the B. burgdorferi polypeptide-specific antibody can be blocked by the B. burgdorferi polypeptide antigen. Such antibodies comprise anti-idiotypic antibodies to the B. burgdorferi polypeptide-specific antibody and can be used to immunize an animal to induce formation of further B. burgdorferi polypeptide-specific antibodies.

Antibodies and fragments thereof of the present invention may be described by the portion of a polypeptide of the present invention recognized or specifically bound by the antibody. Antibody binding fragments of a polypeptide of the present invention may be described or specified in the same manner as for polypeptide fragments discussed above., i.e, by N-terminal and C-terminal positions or by size in contiguous amino acid residues. Any number of antibody binding fragments, of a polypeptide of the present invention, specified by N-terminal and C-terminal positions or by size in amino acid residues, as described above, may also be excluded from the present invention. Therefore, the present invention includes antibodies the specifically bind a particularly described fragment of a polypeptide of the present invention and allows for the exclusion of the same.

Antibodies and fragments thereof of the present invention may also be described or specified in terms of their cross-reactivity. Antibodies and fragments that do not bind polypeptides of any other species of Borrelia other than B. burgdorferi are included in the present invention. Likewise, antibodies and fragments that bind only species of Borrelia, i.e. antibodies and fragments that do not bind bacteria from any genus other than Borrelia, are included in the present invention.

Diagnostic Assays

The present invention further relates to methods for assaying staphylococcal infection in an animal by detecting the expression of genes encoding staphylococcal polypeptides of the present invention. The methods comprise analyzing tissue or body fluid from the animal for Borrelia-specific antibodies, nucleic acids, or proteins. Analysis of nucleic acid specific to Borrelia is assayed by PCR or hybridization techniques using nucleic acid sequences of the present invention as either hybridization probes or primers. See, e.g., Sambrook et al. Molecular cloning. A Laboratory Manual (Cold Spring Harbor Laboratory Press, 2nd ed., 1989, page 54 reference); Eremeeva et al. (1994) J. Clin. Microbiol. 32:803-810 (describing differentiation among spotted fever group Rickettsiae species by analysis of restriction fragment length polymorphism of PCR-amplified DNA) and Chen et al. 1994 J. Clin. Microbiol. 32:589-595 (detecting B. burgdorferi nucleic acids via PCR).

Where diagnosis of a disease state related to infection with Borrelia has already been made, the present invent on is useful for monitoring progression or regression of the disease state whereby patients exhibiting enhanced Borrelia gene expression will experience a worse clinical outcome relative to patients expressing these gene(s) at a lower level.

By “biological sample” is intended any biological sample obtained from an animal, cell line, tissue culture, or other source which contains Borrelia polypeptide, mRNA, or DNA. Biological samples include body fluids (such as saliva, blood, plasma, urine, mucus, synovial fluid, etc.) tissues (such as muscle, skin, and cartilage) and any other biological source suspected of containing Borrelia polypeptides or nucleic acids. Methods for obtaining biological samples such as tissue are well known in the art.

The present invention is useful for detecting diseases related to Borrelia infections in animals. Preferred animals include monkeys, apes, cats, dogs, birds, cows, pigs, mice, horses, rabbits and humans. Particularly preferred are humans.

Total RNA can be isolated from a biological sample using any suitable technique such as the single-step guanidinium-thiocyanate-phenol-chloroform method described in Chomczynski et al. (1987) Anal. Biochem. 162:156-159 mRNA encoding Borrelia polypeptides having sufficient homology to the nucleic acid sequences identified in Table 1 to allow for hybridization between complementary sequences are then assayed using any appropriate method. These include Northern blot analysis, S1 nuclease mapping; the polymerase chain reaction (PCR), reverse transcription in combination with the polymerase chain reaction (RT-PCR), and reverse transcription in combination with the ligase chain reaction (RT-LCR).

Northern blot analysis can be performed as described in Harada et al. (1990) Cell 63:303-312. Briefly, total RNA is prepared from a biological sample as described above. For the Northern blot, the RNA is denatured in an appropriate buffer (such as glyoxal/dimethyl sulfoxide/sodium phosphate buffer), subjected to agarose gel electrophoresis, and transferred onto a nitrocellulose filter. After the RNAs have been linked to the filter by a UV linker, the filter is prehybridized in a solution containing formamide, SSC, Denhardt's solution, denatured salmon sperm, SDS, and sodium phosphate buffer. A B. burgdorferi polynucleotide sequence shown in Table 1 labeled according to any appropriate method (such as the ³²P-multiprimed DNA labeling system (Amersham)) is used as probe. After hybridization overnight, the filter is washed and exposed to x-ray film. DNA for use as probe according to the present invention is described in the sections above and will preferably at least 15 nucleotides in length.

S1 mapping can be performed as described in Fujita et al. (1987) Cell 49:357-367. To prepare probe DNA for use in S1 mapping, the sense strand of an above-described B. burgdorferi DNA sequence of the present invention is used as a template to synthesize labeled antisense DNA. The antisense DNA can then be digested using an appropriate restriction endonuclease to generate further DNA probes of a desired length. Such antisense probes are useful for visualizing protected bands corresponding to the target mRNA (i.e., mRNA encoding Borrelia polypeptides).

Levels of mRNA encoding Borrelia polypeptides are assayed, for e.g., using the RT-PCR method described in Makino et al. (1990) Technique 2:295-301. By this method, the radioactivities of the “amplicons” in the polyacrylamide gel bands are linearly related to the initial concentration of the target mRNA. Briefly, this method involves adding total RNA isolated from a biological sample in a reaction mixture containing a RT primer and appropriate buffer. After incubating for primer annealing, the mixture can be supplemented with a RT buffer, dNTPs, DTT, RNase inhibitor and reverse transcriptase. After incubation to achieve reverse transcription of the RNA, the RT products are then subject to PCR using labeled primers. Alternatively, rather than labeling the primers, a labeled dNTP can be included in the PCR reaction mixture. PCR amplification can be performed in a DNA thermal cycler according to conventional techniques. After a suitable number of rounds to achieve amplification, the PCR reaction mixture is electrophoresed on a polyacrylamide gel. After drying the gel, the radioactivity of the appropriate bands (corresponding to the mRNA encoding the Borrelia polypeptides of the present invention) are quantified using an imaging analyzer. RT and PCR reaction ingredients and conditions, reagent and gel concentrations, and labeling methods are well known in the art. Variations on the RT-PCR method will be apparent to the skilled artisan. Other PCR methods that can detect the nucleic acid of the present invention can be found in PCR PRIMER: A LABORATORY MANUAL (C. W. Dieffenbach et al. eds., Cold Spring Harbor Lab Press, 1995).

The polynucleotides of the present invention, including both DNA and RNA, may be used to detect polynucleotides of the present invention or Borrelia species including B. burgdorferi using bio chip technology. The present invention includes both high density chip arrays (>1000 oligonucleotides per cm²) and low density chip arrays (<1000 oligonucleotides per cm²). Bio chips comprising arrays of polynucleotides of the present invention may be used to detect Borrelia species, including B. burgdorferi, in biological and environmental samples and to diagnose an animal, including humans, with an B. burgdorferi or other Borrelia infection. The bio chips of the present invention may comprise polynucleotide sequences of other pathogens including bacteria, viral, parasitic, and fungal polynucleotide sequences, in addition to the polynucleotide sequences of the present invention, for use in rapid diffenertial pathogenic detection and diagnosis. The bio chips can also be used to monitor an B. burgdorferi or other Borrelia infections and to monitor the genetic changes (deletions, insertions, mismatches, etc.) in response to drug therapy in the clinic and drug development in the laboratory. The bio chip technology comprising arrays of polynucleotides of the present invention may also be used to simultaneously monitor the expression of a multiplicity of genes, including those of the present invention. The polynucleotides used to comprise a selected array may be specified in the same manner as for the fragments, i.e, by their 5′ and 3′ positions or length in contigious base pairs and include from. Methods and particular uses of the polynucleotides of the present invention to detect Borrelia species, including B. burgdorferi, using bio chip technology include those known in the art and those of: U.S. Pat. Nos. 5,510,270; 5,545,531, 5,445,934, 5,677,195, 5,532,128, 5,556,752, 5,527,681, 5,451,683, 5,424,186, 5,607,646, 5,658,732 and World Patent Nos. WO/9710365, WO/9511995, WO/9743447, WO/9535505, each incorporated herein in their entireties.

Biosensors using the polynucleotides of the present invention may also be used to detect, diagnose, and monitor B. burgdorferi or other Borrelia species and infections thereof. Biosensors using the polynucleotides of the present invention may also be used to detect particular polynucleotides of the present invention. Biosensors using the polynucleotides of the present invention may also be used to monitor the genetic changes (deletions, insertions, mismatches, etc.) in response to drug therapy in the clinic and drug development in the laboratory. Methods and particular uses of the polynucleotides of the present invention to detect Borrelia species, including B. burgdorferi, using biosenors include those known in the art and those of: U.S. Pat. Nos. 5,721,102, 5,638,732, 5,631,170, and World Patent Nos. WO97/35011, WO/9720203, each incorporated herein in their entireties.

Thus, the present invention includes both bio chips and biosensors comprising polynucleotides of the present invention and methods of their use.

Assaying Borrelia polypeptide levels in a biological sample can occur using any art-known method, such as antibody-based techniques. For example, Borrelia polypeptide expression in tissues can be studied with classical immunohistological methods. In these, the specific recognition is provided by the primary antibody (polyclonal or monoclonal) but the secondary detection system can utilize fluorescent, enzyme, or other conjugated secondary antibodies. As a result, an immunohistological staining of tissue section for pathological examination is obtained. Tissues can also be extracted, e.g., with urea and neutral detergent, for the liberation of Borrelia polypeptides for Western-blot or dot/slot assay. See, e.g., Jalkanen, M. et al. (1985) J. Cell. Biol: 101:976-985; Jalkanen, M. et al. (1987) J. Cell. Biol. 105:3087-3096. In this technique, which is based on the use of cationic solid phases, quantitation of a Borrelia polypeptide can be accomplished using an isolated Borrelia polypeptide as a standard. This technique can also be applied to body fluids.

Other antibody-based methods useful for detecting Borrelia polypeptide gene expression include immunoassays, such as the ELISA and the radioimmnunoassay (RIA). For example, a Borrelia polypeptide-specific monoclonal antibodies can be used both as an immunoabsorbent and as an enzyme-labeled probe to detect and quantify a Borrelia polypeptide. The amount of a Borrelia polypeptide present in the sample can be calculated by reference to the amount present in a standard preparation using a linear regression computer algorithm; Such an ELISA is described in Iacobelli et al. (1988) Breast Cancer Research and Treatment 11:19-30. In another ELISA assay, two distinct specific monoclonal antibodies can be used to detect Borrelia polypeptides in a body fluid. In this assay, one of the antibodies is used as the immunoabsorbent and the other as the enzyme-labeled probe.

The above techniques may be conducted essentially as a “one-step” or “two-step” assay. The “one-step” assay involves contacting the Borrelia polypeptide with immobilized antibody and, without washing, contacting the mixture with the labeled antibody. The “two-step” assay involves washing before contacting the mixture with the labeled antibody. Other conventional methods may also be employed as suitable. It is usually desirable to immobilize one component of the assay system on a support, thereby allowing other components of the system to be brought into contact with the component and readily removed from the sample. Variations of the above and other immunological methods included in the present invention can also be found in Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988).

Suitable enzyme labels include, for example, those from the oxidase group, which catalyze the production of hydrogen peroxide by reacting with substrate. Glucose oxidase is particularly preferred as it has good stability and its substrate (glucose) is readily available.

Activity of an oxidase label may be assayed by measuring the concentration of hydrogen peroxide formed by the enzyme-labeled antibody/substrate reaction. Besides enzymes, other suitable labels include radioisotopes, such as iodine (¹²⁵I, ¹²¹I), carbon (¹⁴C), sulphur (³⁵S), tritium (3H), indium (¹¹²In), and technetium (^(99m)Tc), and fluorescent labels, such as fluorescein and rhodamine, and biotin.

Further suitable labels for the Borrelia polypeptide-specific antibodies of the present invention are provided below. Examples of suitable enzyme labels include malate dehydrogenase, Borrelia nuclease, delta-5-steroid isomerase, yeast-alcohol dehydrogenase, alpha-glycerol phosphate dehydrogenase, triose phosphate isomerase, peroxidase, alkaline phosphatase, asparaginase, glucose oxidase, beta-galactosidase, ribonuclease, urease, catalase, glucose-6-phosphate dehydrogenase, glucoamylase, and acetylcholine esterase.

Examples of suitable radioisotopic labels include ³H, ¹¹¹In, ¹²⁵I, ¹³¹I, ³²P, ³⁵S, ¹⁴C, ⁵¹Cr, ⁵⁷To, ⁵⁸Co, ⁵⁹Fe, ⁷⁵Se, ¹⁵²Eu, ⁹⁰Y, ⁶⁷Cu, ²¹⁷Ci, ²¹¹At, ²¹²Pb, ⁴⁷Sc, ¹⁰⁹Pd, etc. ¹¹¹In is a preferred isotope where in vivo imaging is used since its avoids the problem of dehalogenation of the ¹²⁵I or ¹³¹I-labeled monoclonal antibody by the liver. In addition, this radionucleotide has a more favorable gamma emission energy for imaging. See, e.g., Perkins et al. (1985) Eur. J. Nucl. Med. 10:296-301; Carasquillo et al. (1987) J. Nucl. Med. 28:281-287. For example, ¹¹¹In coupled to monoclonal antibodies with 1-(P-isothiocyanatobenzyl)-DPTA has shown little uptake in non-tumors tissues, particularly the liver, and therefore enhances specificity of tumor localization. See, Esteban et al. (1987) J. Nucl. Med. 28:861-870.

Examples of suitable non-radioactive isotopic labels include ¹⁵⁷Gd, ⁵⁵Mn, ¹⁶²Dy, ⁵²Tr, and ⁵⁶Fe.

Examples of suitable fluorescent labels include an ¹⁵²Eu label, a fluorescein label, an isothiocyanate label, a rhodamine label, a phycoerythrin label, a phycocyanin label, an allophycocyanin label, an o-phthaldehyde label, and a fluorescamine label.

Examples of suitable toxin labels include, Pseudomonas toxin, diphtheria toxin, ricin, and cholera toxin.

Examples of chemiluminescent labels include a luminal label, an isoluminal label, an aromatic acridinium ester label, an imidazole label, an acridinium salt label, an oxalate ester label, a luciferin label, a luciferase label, and an aequorin label.

Examples of nuclear magnetic resonance contrasting agents include heavy metal nuclei such as Gd, Mn, and iron.

Typical techniques for binding the above-described labels to antibodies are provided by Kennedy et al. (1976) Clin. Chim. Acta 70:1-31, and Schurs et al. (1977) Clin. Chim. Acta 81:1-40. Coupling techniques mentioned in the latter are the glutaraldehyde method, the periodate method, the dimaleimide method, the m-maleimidobenzyl-N-hydroxy-succinimide ester method, all of which methods are incorporated by reference herein.

In a related aspect, the invention includes a diagnostic kit for use in screening serum containing antibodies specific against B. burgdorferi infection. Such a kit may include an isolated B. burgdorferi antigen comprising an epitope which is specifically immunoreactive with at least one anti-B. burgdorferi antibody. Such a kit also includes means for detecting the binding of said antibody to the antigen. In specific embodiments, the kit may include a recombinantly produced or chemically synthesized peptide or polypeptide antigen. The peptide or polypeptide antigen may be attached to a solid support.

In a more specific embodiment, the detecting means of the above-described kit includes a solid support to which said peptide or polypeptide antigen is attached. Such a kit may also include a non-attached reporter-labeled anti-human antibody. In this embodiment, binding of the antibody to the B. burgdorferi antigen can be detected by binding of the reporter labeled antibody to the anti-B. burgdorferi polypeptide antibody.

In a related aspect, the invention includes a method of detecting B. burgdorferi infection in a subject. This detection method includes reacting a body fluid, preferably serum, from the subject with an isolated B. burgdorferi antigen, and examining the antigen for the presence of bound antibody. In a specific embodiment, the method includes a polypeptide antigen attached to a solid support, and serum is reacted with the support. Subsequently, the support is reacted with a reporter-labeled anti-human antibody. The support is then examined for the presence of reporter-labeled antibody.

The solid surface reagent employed in the above assays and kits is prepared by known techniques for attaching protein material to solid support material, such as polymeric beads, dip sticks, 96-well plates or filter material. These attachment methods generally include non-specific adsorption of the protein to the support or covalent attachment of the protein., typically through a free amine group, to a chemically reactive group on the solid support, such as an activated carboxyl, hydroxyl, or aldehyde group. Alternatively, streptavidin coated plates can be used in conjunction with biotinylated antigen(s).

The polypeptides and antibodies of the present invention, including fragments thereof, may be used to detect Borrelia species including B. burgdorferi using bio chip and biosensor technology. Bio chip and biosensors of the present invention may comprise the polypeptides of the present invention to detect antibodies, which specifically recognize Borrelia species, including B. burgdorferi. Bio chip and biosensors of the present invention may also comprise antibodies which specifically recognize the polypeptides of the present invention to detect Borrelia species, including B. burgdorferi or specific polypeptides of the present invention. Bio chips or biosensors comprising polypeptides or antibodies of the present invention may be used to detect Borrelia species, including B. burgdorferi, in biological and environmental samples and to diagnose an animal, including humans, with an B. burgdorferi or other Borrelia infection. Thus, the present invention includes both bio chips and biosensors comprising polypeptides or antibodies of the present invention and methods of their use.

The bio chips of the present invention may further comprise polypeptide sequences of other pathogens including bacteria, viral, parasitic, and fungal polypeptide sequences, in addition to the polypeptide sequences of the present invention, for use in rapid diffenertial pathogenic detection and diagnosis. The bio chips of the present invention may further comprise-antibodies or fragments thereof specific for other pathogens including bacteria, viral, parasitic, and fungal polypeptide sequences, in addition to the antibodies or fragments thereof of the present invention, for use in rapid diffenertial pathogenic detection and diagnosis. The bio chips and biosensors of the present invention may also be used to monitor an B. burgdorferi or other Borrelia infection and to monitor the genetic changes (amio acid deletions, insertions, substitutions, etc.) in response to drug therapy in the clinic and drug development in the laboratory. The bio chip and biosensors comprising polypeptides or antibodies of the present invention may also be used to simultaneously monitor the expression of a multiplicity of polypeptides, including those of the present invention. The polypeptides used to comprise a bio chip or biosensor of the present invention may be specified in the same manner as for the fragments, i.e, by their N-terminal and C-terminal positions or length in contigious amino acid residue. Methods and particular uses of the polypeptides and antibodies of the present invention to detect Borrelia species, including B. burgdorferi, or specific polypeptides using bio chip and biosensor technology include those known in the art, those of the U.S. patent Nos. and World Patent Nos. listed above for bio chips and biosensors using polynucleotides of the present invention, and those of: U.S. Pat. Nos. 5,658,732, 5,135,852, 5,567,301, 5,677,196, 5,690,894 and World Patent Nos. W09729366, WO9612957, each incorporated herein in their entireties.

Treatment:

Agonists and Antagonists—Assays and Molecules

The invention also provides a method of screening compounds to identify those which enhance or block the biological activity of the B. burgdorferi polypeptides of the present invention. The present invention further provides where the compounds kill or slow the growth of B. burgdorferi. The ability of B. burgdorferi antagonists, including B. burgdorferi ligands, to prophylactically or therapeutically block antibiotic resistance may be easily tested by the skilled artisan. See, e.g., Straden et al. (1997) J. Bacteriol. 179(1):9-16.

An agonist is a compound which increases the natural biological function or which functions in a manner similar to the polypeptides of the present invention, while antagonists decrease or eliminate such functions. Potential antagonists include small organic molecules, peptides, polypeptides, and antibodies that bind to a polypeptide of the invention and thereby inhibit or extinguish its activity.

The antagonists may be employed for instance to inhibit peptidoglycan cross bridge formation. Antibodies against B. burgdorferi may be employed to bind to and inhibit B. burgdorferi activity to treat antibiotic resistance. Any of the above antagonists may be employed in a composition with a pharmaceutically acceptable carrier.

Vaccines

The present invention also provides vaccines comprising one or more polypeptides of the present invention. Heterogeneity in the composition of a vaccine may be provided by combining B. burgdorferi polypeptides of the present invention. Multi-component vaccines of this type are desirable because they are likely to be more effective in eliciting protective immune responses against multiple species and strains of the Borrelia genus than single polypeptide vaccines. Thus, as discussed in detail below, a multi-component vaccine of the present invention may contain one or more, preferably 2 to about 20, more preferably 2 to about 15, and most preferably 3 to about 8, of the B. burgdorferi polypeptides shown in Table 1, or fragments thereof.

Multi-component vaccines are known in the art to elicit antibody production to numerous immunogenic components. Decker, M. and Edwards, K., J. Infect. Dis. 174:S270-275 (1996). In addition, a hepatitis B, diphtheria, tetanus, pertussis tetravalent vaccine has recently been demonstrated to elicit protective levels of antibodies in human infants against all four pathogenic agents. Aristegui, J. et al., Vaccine 15:7-9 (1997).

The present invention thus also includes multi-component vaccines. These vaccines comprise more than one polypeptide, immunogen or antigen. An example of such a multi-component vaccine would be a vaccine comprising more than one of the B. burgdorferi polypeptides shown in Table 1. A second example is a vaccine comprising one or more, for example 2 to 10, of the B. burgdorferi polypeptides shown in Table 1 and one or more, for example 2 to 10, additional polypeptides of either borrelial or non-borrelial origin. Thus, a multi-component vaccine which confers protective immunity to both a borrelial infection and infection by another pathogenic agent is also within the scope of the invention.

As indicated above, the vaccines of the present invention are expected to elicit a protective immune response against infections caused by species and strains of Borrelia other than B. burgdorferi sensu stricto isolate B31 (ATCC Accession No. 35210). Immunizations using decorin-binding protein and OspA derived from one strain of B. burgdorferi has been shown to elicit the production of antiserum which confers passive immunity against other strains of B. burgdorferi. Cassatt, D. et al., Protection of Borrelia burgdorferi Infection by Antibodies to Decorin-binding Protein, in VACCINES97; Cold Spring Harbor Press (1997), pages 191-195. Further, the inventors have found using an in vitro assay that antiserum produced in response to B. burgdorferi decorin-binding protein will kill several species of Borrelia. The amino acid sequences of decorin-binding protein expressed by different strains of B. burgdorferi are believed to diverge by as much as 25%. Thus, antisera elicited against decorin-binding proteins confers passive immunity against Borrelia expressing proteins having only 75% or less amino acid sequence similarity.

Further within the scope of the invention are whole cell and whole viral vaccines. Such vaccines may be produced recombinantly and involve the expression of one or more of the B. burgdorferi polypeptides shown in Table 1. For example, the B. burgdorferi polypeptides of the present invention may be either secreted or localized intracellular, on the cell surface, or in the periplasmic space. Further, when a recombinant virus is used, the B. burgdorferi polypeptides of the present invention may, for example, be localized in the viral envelope, on the surface of the capsid, or internally within the capsid. Whole cells vaccines which employ cells expressing heterologous proteins are known in the art. See, e.g., Robinson, K. et al., Nature Biotech. 15:653-657 (1997); Sirard, J. et al., Infect. Immun. 65:2029-2033 (1997); Chabalgoity, J. et al., Infect. Immun. 65:2402-2412 (1997). These cells may be administered live or may be killed prior to administration. Chabalgoity, J. et al., supra, for example, report the successful use in mice of a live attenuated Salmonella vaccine strain which expresses a portion of a platyhelminth fatty acid-binding protein as a fusion protein on its cells surface.

A multi-component vaccine can also be prepared using techniques known in the art by combining one or more B. burgdorferi polypeptides of the present invention, or fragments thereof, with additional non-borrelial components (e.g., diphtheria toxin or tetanus toxin, and/or other compounds known to elicit an immune response). Such vaccines are useful for eliciting protective immune responses to both members of the Borrelia genus and non-borrelial pathogenic agents.

The vaccines of the present invention also include DNA vaccines. DNA vaccines are currently being developed for a number of infectious diseases. Boyer, J et al., Nat. Med. 3:526-532 (1997); reviewed in Spier, R., Vaccine 14:1285-1288 (1996). Such DNA vaccines contain a nucleotide sequence encoding one or more B. burgdorferi polypeptides of the present invention oriented in a manner that allows for expression of the subject polypeptide. The direct administration of plasmid DNA encoding OspA has been shown to elicit protective immunity in mice against borrelial challenge. Luke, C. et al., J. Infect. Dis. 175:91-97 (1997).

The present invention also relates to the administration of a vaccine which is co-administered with a molecule capable of modulating immune responses. Kim, J. et al., Nature Biotech. 15:641-646 (1997), for example, report the enhancement of immune responses produced by DNA immunizations when DNA sequences encoding molecules which stimulate the immune response are co-administered. In a similar fashion, the vaccines of the present invention may be co-administered with either nucleic acids encoding immune modulators or the immune modulators themselves. These immune modulators include granulocyte macrophage colony stimulating factor (GM-CSF) and CD86.

The vaccines of the present invention may be used to confer resistance to borrelial infection by either passive or active immunization. When the vaccines of the present invention are used to confer resistance to borrelial infection through active immunization, a vaccine of the present invention is administered to an animal to elicit a protective immune response which either prevents or attenuates a borrelial infection. When the vaccines of the present invention are used to confer resistance to borrelial infection through passive immunization, the vaccine is provided to a host animal (e.g., human, dog, or mouse), and the antisera elicited by this antisera is recovered and directly provided to a recipient suspected of having an infection caused by a member of the Borrelia genus.

The ability to label antibodies, or fragments of antibodies, with toxin molecules provides an additional method for treating borrelial infections when passive immunization is conducted. In this embodiment, antibodies, or fragments of antibodies, capable of recognizing the B. burgdorferi polypeptides disclosed herein, or fragments thereof, as well as other Borrelia proteins, are labeled with toxin molecules prior to their administration to the patient. When such toxin derivatized antibodies bind to Borrelia cells, toxin moieties will be localized to these cells and will cause their death.

The present invention thus concerns and provides a means for preventing or attenuating a borrelial infection resulting from organisms which have antigens that are recognized and bound by antisera produced in response to the polypeptides of the present invention. As used herein, a vaccine is said to prevent or attenuate a disease if its administration to an animal results either in the total or partial attenuation (i.e., suppression) of a symptom or condition of the disease, or in the total or partial immunity of the animal to the disease.

The administration of the vaccine (or the antisera which it elicits) may be for either a “prophylactic” or “therapeutic” purpose. When provided prophylactically, the compound(s) are provided in advance of any symptoms of borrelial infection. The prophylactic administration of the compound(s) serves to prevent or attenuate any subsequent infection. When provided therapeutically, the compound(s) is provided upon or after the detection of symptoms which indicate that an animal may be infected with a member of the Borrelia genus. The therapeutic administration of the compound(s) serves to attenuate any actual infection. Thus, the B. burgdorferi polypeptides, and fragments thereof, of the present invention may be provided either prior to the onset of infection (so as to prevent or attenuate an anticipated infection) or after the initiation of an actual infection.

The polypeptides of the invention, whether encoding a portion of a native protein or a functional derivative thereof, may be administered in pure form or may be coupled to a macromolecular carrier. Example of such carriers are proteins and carbohydrates. Suitable proteins which may act as macromolecular carrier for enhancing the immunogenicity of the polypeptides of the present invention include keyhole limpet hemacyanin (KLH) tetanus toxoid, pertussis toxin, bovine serum albumin, and ovalbumin. Methods for coupling the polypeptides of the present invention to such macromolecular carriers are disclosed in Harlow et al., Antibodies: A Laboratory Manual, 2nd Ed.; Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1988), the entire disclosure of which is incorporated by reference herein.

A composition is said to be “pharmacologically acceptable” if its administration can be tolerated by a recipient animal and is otherwise suitable for administration to that animal. Such an agent is said to be administered in a “therapeutically effective amount” if the amount administered is physiologically significant. An agent is physiologically significant if its presence results in a detectable change in the physiology of a recipient patient.

While in all instances the vaccine of the present invention is administered as a pharmacologically acceptable compound, one skilled in the art would recognize that the composition of a pharmacologically acceptable compound varies with the animal to which it is administered. For example, a vaccine intended for human use will generally not be co-administered with Freund's adjuvant. Further, the level of purity of the B. burgdorferi polypeptides of the present invention will normally be higher when administered to a human than when administered to a non-human animal.

As would be understood by one of ordinary skill in the art, when the vaccine of the present invention is provided to an animal, it may be in a composition which may contain salts, buffers, adjuvants, or other substances which are desirable for improving the efficacy of the composition. Adjuvants are substances that can be used to specifically augment a specific immune response. These substances generally perform two functions: (1) they protect the antigen(s) from being rapidly catabolized after administration and (2) they nonspecifically stimulate immune responses.

Normally, the adjuvant and the composition are mixed prior to presentation to the immune system, or presented separately, but into the same site of the animal being immunized. Adjuvants can be loosely divided into several groups based upon their composition. These groups include oil adjuvants (for example, Freund's complete and incomplete), mineral salts (for example, AlK(SO₄)₂, AlNa(SO₄)₂, AlNH₄(SO₄), silica, kaolin, and carbon), polynucleotides (for example, poly IC and poly AU acids), and certain natural substances (for example, wax D from Mycobacterium tuberculosis, as well as substances found in Corynebacterium parvum, or Bordetella pertussis, and members of the genus Brucella. Other substances useful as adjuvants are the saponins such as, for example, Quil A. (Superfos A/S, Denmark). Preferred adjuvants for use in the present invention include aluminum salts, such as AlK(SO₄)₂, AlNa(SO₄)₂, and AlNH₄(SO₄). Examples of materials suitable for use in vaccine compositions are provided in Remington's Pharmaceutical Sciences (Osol, A, Ed, Mack Publishing Co, Easton, Pa., pp. 1324-1341 (1980), which reference is incorporated herein by reference).

The therapeutic compositions of the present invention can be administered parenterally by injection, rapid infusion, nasopharyngeal absorption (intranasopharangeally), dermoabsorption, or orally. The compositions may alternatively be administered intramuscularly, or intravenously Compositions for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, and emulsions. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable organic esters such as ethyl oleate. Carriers or occlusive dressings can be used to increase skin permeability and enhance antigen absorption. Liquid dosage forms for oral administration may generally comprise a liposome solution containing the liquid dosage form. Suitable forms for suspending liposomes include emulsions, suspensions, solutions, syrups, and elixirs containing inert diluents commonly used in the art, such as purified water. Besides the inert diluents, such compositions can also include adjuvants, wetting agents, emulsifying and suspending agents, or sweetening, flavoring, or perfuming agents.

Therapeutic compositions of the present invention can also be administered in encapsulated form. For example, intranasal immunization of mice against Bordetella pertussis infection using vaccines encapsulated in biodegradable microsphere composed of poly(DL-lactide-co-glycolide) has been shown to stimulate protective immune responses. Shahin; R. et al., Infect. Immun. 63:1195-1200 (1995). Similarly, orally administered encapsulated Salmonella typhimurium antigens have also been shown to elicit protective immunity in mice. Allaoui-Attarki, K. et al., Infect. Immun. 65:853-857 (1997). Encapsulated vaccines of the present invention can be administered by a variety of routes including those involving contacting the vaccine with mucous membranes (e.g., intranasally, intracolonicly, intraduodenally).

Many different techniques exist for the timing of the immunizations when a multiple administration regimen is utilized. It is possible to use the compositions of the invention more than once to increase the levels and diversities of expression of the immunoglobulin repertoire expressed by the immunized animal. Typically, if multiple immunizations are given, they will be given one to two months apart.

According to the present invention, an “effective amount” of a therapeutic composition is one which is sufficient to achieve a desired biological effect. Generally, the dosage needed to provide an effective amount of the composition will vary depending upon such factors as the animal's or human's age, condition, sex, and extent of disease, if any, and other variables which can be adjusted by one of ordinary skill in the art.

The antigenic preparations of the invention can be administered by either single or multiple dosages of an effective amount. Effective amounts of the compositions of the invention can vary from 0.01-1,000 μg/ml per dose, more preferably 0.1-500 μg/ml per dose, and most preferably 10-300 μg/ml per dose.

Having now generally described the invention, the same will be more readily understood through reference to the following example which is provided by way of illustration, and is not intended to be limiting of the present invention, unless specified.

EXAMPLES

1. Preparation of PCR Primers and Amplification of DNA

Various fragments of the Borrelia burgdorferi genome, such as those of Table 1, can be used, in accordance with the present invention, to prepare PCR primers for a variety of users. The PCR primers are preferably at least 15 bases, and more preferably at least 18 bases in length. When selecting a primer sequence, it is preferred that the primer pairs have approximately the same G/C ratio, so that melting temperatures are approximately the same. The PCR primers and amplified DNA of this Example find use in the Examples that follow.

2. Isolation of a Selected DNA Clone From B. burgdorferi

Three approaches are used to isolate a B. burgdorferi clone comprising a polynucleotide of the present invention from any B. burgdorferi genomic DNA library. The B. burgdorferi strain B31PU has been deposited as a convienent source for obtaining a B. burgdorferi strain although a wide varity of strains B. burgdorferi strains can be used which are known in the art.

B. burgdorferi genomic DNA is prepared using the following method. A 20 ml overnight bacterial culture grown in a rich medium (e.g., Trypticase Soy Broth, Brain Heart Infusion broth or Super broth), pelleted, ished two times with TES (30 mM Tris-pH 8.0, 25 mM EDTA, 50 mM NaCl), and resuspended in 5 ml high salt TES (2.5M NaCl). Lysostaphin is added to final concentration of approx 50 ug/ml and the mixture is rotated slowly 1 hour at 37 C to make protoplast cells. The solution is then placed in incubator (or place in a shaking water bath) and warmed to 55 C. Five hundred micro liter of 20% sarcosyl in TES (final concentration 2%) is then added to lyse the cells. Next, guanidine HCl is added to a final concentration of 7M (3.69 g in 5.5 ml). The mixture is swirled slowly at 55 C for 60-90 min (solution should clear). A CsCl gradient is then set up in SW41 ultra clear tubes using 2.0 ml 5.7M CsCl and overlaying with 2.85M CsCl. The gradient is carefully overlayed with the DNA-containing GuHCl solution. The gradient is spun at 30,000 rpm, 20 C for 24 hr and the lower DNA band is collected. The volume is increased to 5 ml with TE buffer. The DNA is then treated with protease K (10 ug/ml) overnight at 37 C, and precipitated with ethanol. The precipitated DNA is resuspended in a desired buffer.

In the first method, a plasmid is directly isolated by screening a plasmid B. burgdorferi genomic DNA library using a polynucleotide probe corresponding to a polynucleotide of the present invention. Particularly, a specific polynucleotide with 30-40 nucleotides is synthesized using an Applied Biosystems DNA synthesizer according to the sequence reported. The oligonucleotide is labeled, for instance, with ³²P-γ-ATP using T4 polynucleotide kinase and purified according to routine methods. (See, e.g., Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring, N.Y. (1982).) The library is transformed into a suitable host, as indicated above (such as XL-1 Blue (Stratagene)) using techniques known to those of skill in the art. See, e.g., Sambrook et al. MOLECULAR CLONING: A LABORATORY MANUAL (Cold Spring Harbor, N.Y. 2nd ed. 1989); Ausubel et al., CURRENT PROTOCALS IN MOLECULAR BIOLOGY (John Wiley and Sons, N.Y. 1989). The transformants are plated on 1.5% agar plates (containing the appropriate selection agent, e.g., ampicillin) to a density of about 150 transformants (colonies) per plate. These plates are screened using Nylon membranes according to routine methods for bacterial colony screening. See, e.g., Sambrook et al. MOLECULAR CLONING: A LABORATORY MANUAL (Cold Spring Harbor, N.Y. 2nd ed. 1989); Ausubel et al., CURRENT PROTOCALS IN MOLECULAR BIOLOGY (John Wiley and Sons, N.Y. 1989) or other techniques known to those of skill in the art.

Alternatively, two primers of 15-25 nucleotides derived from the 5′ and 3′ ends of a polynucleotide of Table 1 are synthesized and used to amplify the desired DNA by PCR using a B. burgdorferi genomic DNA prep as a template. PCR is carried out under routine conditions, for instance, in 25 μl of reaction mixture with 0.5 ug of the above DNA template. A convenient reaction mixture is 1.5-5 mM MgCl₂, 0.01% (w/v) gelatin, 20 μM each of dATP, dCTP, dGTP, dTTP, 25 pmol of each primer and 0.25 Unit of Taq polymerase. Thirty five cycles of PCR (denaturation at 94° C. for 1 min; annealing at 55° C. for 1 min; elongation at 72° C. for 1 min) are performed with a Perkin-Elmer Cetus automated thermal cycler. The amplified product is analyzed by agarose gel electrophoresis and the DNA band with expected molecular weight is excised and purified. The PCR product is verified to be the selected sequence by subcloning and sequencing the DNA product.

Finally, overlapping oligos of the DNA sequences of Table 1 can be chemically synthesized and used to generate a nucleotide sequence of desired length using PCR methods known in the art.

3(a). Expression and Purification Borrelia Polypeptides in E. coli

The bacterial expression vector pQE60 is used for bacterial expression of some of the polypeptide fragments of the present invention. (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311). pQE60 encodes ampicillin antibiotic resistance (“Ampr”) and contains a bacterial origin of replication (“ori”), an IPTG inducible promoter, a ribosome binding site (“RBS”), six codons encoding histidine residues that allow affinity purification using nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin (QIAGEN, Inc., supra) and suitable single restriction enzyme cleavage sites. These elements are arranged such that an inserted DNA fragment encoding a polypeptide expresses that polypeptide with the six His residues (i.e., a “6× His tag”) covalently linked to the carboxyl terminus of that polypeptide.

The DNA sequence encoding the desired portion of a B. burgdorferi protein of the present invention is amplified from B. burgdorferi genomic DNA using PCR oligonucleotide primers which anneal to the 5′ and 3′ sequences coding for the portions of the B. burgdorferi polynucleotide shown in Table 1. Additional nucleotides containing restriction sites to facilitate cloning in the pQE60 vector are added to the 5′ and 3′ sequences, respectively.

For cloning the mature protein, the 5′ primer has a sequence containing an appropriate restriction site followed by nucleotides of the amino terminal coding sequence of the desired B. burgdorferi polynucleotide sequence in Table 1. One of ordinary skill in the art would appreciate that the point in the protein coding sequence where the 5′ and 3′ primers begin may be varied to amplify a DNA segment encoding any desired portion of the complete protein shorter or longer than the mature form. The 3′ primer has a sequence containing an appropriate restriction site followed by nucleotides complementary to the 3′ end of the polypeptide coding sequence of Table 1, excluding a stop codon, with the coding sequence aligned with the restriction site so as to maintain its reading frame with that of the six His codons in the pQE60 vector.

The amplified B. burgdorferi DNA fragment and the vector pQE60 are digested with restriction enzymes which recognize the sites in the primers and the digested DNAs are then ligated together. The B. burgdorferi DNA is inserted into the restricted pQE60 vector in a mariner which places the B. burgdorferi protein coding region downstream from the IPTG-inducible promoter and in-frame with an initiating AUG and the six histidine codons.

The ligation mixture is transformed into competent E. coli cells using standard procedures such as those described by Sambrook et al., supra. E. coli strain M15/rep4, containing multiple copies of the plasmid pREP4, which expresses the lac repressor and confers kanamycin resistance (“Kanr”), is used in carrying out the illustrative example described herein. This strain, which is only one of many that are suitable for expressing a B. burgdorferi polypeptide, is available commercially (QIAGEN, Inc., supra). Transformants are identified by their ability to grow on LB agar plates in the presence of ampicillin and kanamycin. Plasmid DNA is isolated from resistant colonies and the identity of the cloned DNA confirmed by restriction analysis, PCR and DNA sequencing.

Clones containing the desired constructs are grown overnight (“O/N”) in liquid culture in LB media supplemented with both ampicillin (100 μg/ml) and kanamycin (25 μg/ml). The O/N culture is used to inoculate a large culture, at a dilution of approximately 1:25 to 1:250. The cells are grown to an optical density at 600 nm (“OD600”) of between 0.4 and 0.6. Isopropyl-β-D-thiogalactopyranoside (“IPTG”) is then added to a final concentration of 1 mM to induce transcription from the lac repressor sensitive promoter, by inactivating the lacI repressor. Cells subsequently are incubated further for 3 to 4 hours. Cells then are harvested by centrifugation.

The cells are then stirred for 3-4 hours at 4° C. in 6M guanidine-HCl, pH 8. The cell debris is removed by centrifugation, and the supernatant containing the B. burgdorferi polypeptide is loaded onto a nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin column (QIAGEN, Inc., supra). Proteins with a 6× His tag bind to the Ni-NTA resin with high affinity are purified in a simple one-step procedure (for details see: The QIAexpressionist, 1995, QIAGEN, Inc., supra). Briefly the supernatant is loaded onto the column in 6 M guanidine-HCl, pH 8, the column is first washed with 10 volumes of 6 M guanidine-HCl, pH 8, then washed with 10 volumes of 6 M guanidine-HCl pH 6, and finally the B. burgdorferi polypeptide is eluted with 6 M guanidine-HCl, pH 5.

The purified protein is then renatured by dialyzing it against phosphate-buffered saline (PBS) or 50 μM Na-acetate, pH 6 buffer plus 200 mM NaCl. Alternatively, the protein could be successfully refolded while immobilized on the Ni-NTA column. The recommended conditions are as follows: renature using a linear 6M-1M urea gradient in 500 mM NaCl, 20% glycerol, 20 mM Tris/HCl pH 7.4, containing protease inhibitors. The renaturation should be performed over a period of 1.5 hours or more. After renaturation the proteins can be eluted by the addition of 250 mM immidazole. Immidazole is removed by a final dialyzing step against PBS or 50 mM sodium acetate pH 6 buffer plus 200 mM NaCl. The purified protein is stored at 4° C. or frozen at −80° C.

The polypeptide of the present invention are also prepared using a non-denaturing protein purification method. For these polypeptides, the cell pellet from each liter of culture is resuspended in 25 mls of Lysis Buffer A at 4° C. (Lysis Buffer A=50 mM Na-phosphate, 300 mM NaCl, 10 mM 2-mercaptoethanol, 10% Glycerol, pH 7.5 with 1 tablet of Complete EDTA-free protease inhibitor cocktail (Boehringer Mannheim #1873580) per 50 ml of buffer). Absorbance at 550 nm is approximately 10-20 O.D./ml. The suspension is then put through three freeze/thaw cycles from −70° C. (using a ethanol-dry ice bath) up to room temperature. The cells are lysed via sonication in short 10 sec bursts over 3 minutes at approximately 80 W while kept on ice. The sonicated sample is then centrifuged at 15,000 RPM for 30 minutes at 4° C. The supernatant is passed through a column containing 1.0 ml of CL-4B resin to pre-clear the sample of any proteins that may bind to agarose non-specifically, and the flow-through fraction is collected.

The pre-cleared flow-through is applied to a nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin column (Quiagen, Inc., supra). Proteins with a 6× His tag bind to the Ni-NTA resin with high affinity and can be purified in a simple one-step procedure. Briefly, the supernatant is loaded onto the column in Lysis Buffer A at 4° C., the column is first washed with 10 volumes of Lysis Buffer A until the A280 of the eluate returns to the baseline. Then, the column is washed with 5 volumes of 40 mM Imidazole (92% Lysis Buffer A/8% Buffer B) (Buffer B=50 mM Na-Phosphate, 300 mM NaCl, 10% Glycerol, 10 mM 2-mercaptoethanol, 500 mM Imidazole, pH of the final buffer should be 7.5). The protein is eluted off of the column with a series of increasing Imidazole solutions made by adjusting the ratios of Lysis Buffer A to Buffer B. Three different concentrations are used: 3 volumes of 75 mM imidazole, 3 volumes of 150 mM Imidazole, 5 volumes of 500 mM Imidazole. The fractions containing the purified protein are analyzed using 8%, 10% or 14% SDS-PAGE depending on the protein size. The purified protein is then dialyzed 2× against phosphate-buffered saline (PBS) in order to place it into an easily workable buffer. The purified protein is stored at 4° C. or frozen at −80°.

The following alternative method may be used to purify B. burgdorferi expressed in E. coli when it is present in the form of inclusion bodies. Unless otherwise specified, all of the following steps are conducted at 4-10° C.

Upon completion of the production phase of the E. coli fermentation, the cell culture is cooled to 4-10° C. and the cells are harvested by continuous centrifugation at 15,000 rpm (Heraeus Sepatech). On the basis of the expected yield of protein per unit weight of cell paste and the amount of purified protein required, an appropriate amount of cell paste, by weight, is suspended in a buffer solution containing 100 mM Tris, 50 mM EDTA, pH 7.4. The cells are dispersed to a homogeneous suspension using a high shear mixer.

The cells are then lysed by passing the solution through a microfluidizer (Microfuidics, Corp. or APV Gaulin, Inc.) twice at 4000-6000 psi. The homogenate is then mixed with NaCl solution to a final concentration of 0.5 M NaCl, followed by centrifugation at 7000×g for 15 min. The resultant pellet is washed again using 0.5M NaCl, 100 mM Tris, 50 mM EDTA, pH 7.4.

The resulting washed inclusion bodies are solubilized with 1.5 M guanidine hydrochloride (GuHCl) for 2-4 hours. After 7000×g centrifugation for 15 min., the pellet is discarded and the B. burgdorferi polypeptide-containing supernatant is incubated at 4° C. overnight to allow further GuHCl extraction.

Following high speed centrifugation (30,000×g) to remove insoluble particles, the GuHCl solubilized protein is refolded by quickly mixing the GuHCl extract with 20 volumes of buffer containing 50 mM sodium, pH 4.5, 150 mM NaCl, 2 mM EDTA by vigorous stirring. The refolded diluted protein solution is kept at 4° C. without mixing for 12 hours prior to further purification steps.

To clarify the refolded B. burgdorferi polypeptide solution, a previously prepared tangential filtration unit equipped with 0.16 μm membrane filter with appropriate surface area (e.g., Filtron), equilibrated with 40 mM sodium acetate, pH 6.0 is employed. The filtered sample is loaded onto a cation exchange resin (e.g., Poros HS-50, Perseptive Biosystems). The column is washed with 40 mM sodium acetate, pH 6.0 and eluted with 250 mM, 500 mM, 1000 mM, and 1500 mM NaCl in the same buffer, in a stepwise marker. The absorbance at 280 mm of the effluent is continuously monitored. Fractions are collected and further analyzed by SDS-PAGE.

Fractions containing the B. burgdorferi polypeptide are then pooled and mixed with 4 volumes of water. The diluted sample is then loaded onto a previously prepared set of tandem columns of strong anion (Poros HQ-50, Perseptive Biosystems) and weak anion (Poros CM-20, Perseptive Biosystems) exchange resins. The columns are equilibrated with 40 mM sodium acetate, pH 6.0. Both columns are washed with 40 mM sodium acetate, pH 6.0, 200 mM NaCl. The CM-20 column is then eluted using a 10 column volume linear gradient ranging from 0.2 M NaCl, 50 mM sodium acetate, pH 6.0 to 1.0 M NaCl, 50 mM sodium acetate, pH 6.5. Fractions are collected under constant A₂₈₀ monitoring of the effluent. Fractions containing the B. burgdorferi polypeptide (determined, for instance, by 16% SDS-PAGE) are then pooled.

The resultant B. burgdorferi polypeptide exhibits greater than 95% purity after the above refolding and purification steps. No major contaminant bands are observed from Commassie blue stained 16% SDS-PAGE gel when 5 μg of purified protein is loaded. The purified protein is also tested for endotoxin/LPS contamination, and typically the LPS content is less than 0.1 ng/ml according to LAL assays.

3(b). Alternative Expression and Purification Borrelia Polypeptides in E. coli

Tthe vector pQE10 is alternatively used to clone and express some of the polypeptides of the present invention for use in the soft tissue and systemic infection models discussed below. The difference being such that an inserted DNA fragment encoding a polypeptide expresses that polypeptide with the six His residues (i.e., a “6× His tag”) covalently linked to the amino terminus of that polypeptide. The bacterial expression vector pQE 10 (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311) was used in this example. The components of the pQE10 plasmid are arranged such that the inserted DNA sequence encoding a polypeptide of the present invention expresses the polypeptide with the six His residues (i.e., a “6× His tag”)) covalently linked to the amino terminus.

The DNA sequences encoding the desired portions of a polypeptide of Table 1 were amplified using PCR oligonucleotide primers from genomic B. burgdorferi DNA. The PCR primers anneal to the nucleotide sequences encoding the desired amino acid sequence of a polypeptide of the present invention. Additional nucleotides containing restriction sites to facilitate cloning in the pQE10 vector were added to the 5′ and 3′ primer sequences, respectively.

For cloning a polypeptide of the present invention, the 5′ and 3′ primers were selected to amplify their respective nucleotide coding sequences. One of ordinary skill in the art would appreciate that the point in the protein coding sequence where the 5′ and 3′ primers begins may be varied to amplify a DNA segment encoding any desired portion of a polypeptide of the present invention. The 5′ primer was designed so the coding sequence of the 6× His tag is aligned with the restriction site so as to maintain its reading frame with that of B. burgdorferi polypeptide. The 3′ was designed to include an stop codon. The amplified DNA fragment was then cloned, and the protein expressed, as described above for the pQE60 plasmid.

The DNA sequences of Table 1 encoding amino acid sequences may also be cloned and expressed as fusion proteins by a protocol similar to that described directly above, wherein the pET-32b(+) vector (Novagen, 601 Science Drive, Madison, Wis. 53711) is preferentially used in place of pQE10.

The above methods are not limited to the polypeptide fragments actually produced. The above method, like the methods below, can be used to produce either full length polypeptides or desired fragments thereof.

3(c). Alternative Expression and Purification of Borrelia Polypeptides in E. coli

The bacterial expression vector pQE60 is used for bacterial expression in this example (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 9131.1). However, in this example, the polypeptide coding sequence is inserted such that translation of the six His codons is prevented and, therefore, the polypeptide is produced with no 6× His tag.

The DNA sequence encoding the desired portion of the B. burgdorferi amino acid sequence is amplified from an B. burgdorferi genomic DNA prep the deposited DNA clones using PCR oligonucleotide primers which anneal to the 5′ and 3′ nucleotide sequences corresponding to the desired portion of the B. burgdorferi polypeptides. Additional nucleotides containing restriction sites to facilitate cloning in the pQE60 vector are added to the 5′ and 3′ primer sequences.

For cloning a B. burgdorferi polypeptides of the present invention, 5′ and 3′ primers are selected to amplify their respective nucleotide coding sequences. One of ordinary skill in the art would appreciate that the point in the protein coding sequence where the 5′ and 3′ primers begin may be varied to amplify a DNA segment encoding any desired portion of a polypeptide of the present invention. The 3′ and 5′ primers contain appropriate restriction sites followed by nucleotides complementary to the 5′ and 3′ ends of the coding sequence respectively. The 3′ primer is additionally designed to include an in-frame stop codon.

The amplified B. burgdorferi DNA fragments and the vector pQE60 are digested with restriction enzymes recognizing the sites in the primers and the digested DNAs are then ligated together. Insertion of the B. burgdorferi DNA into the restricted pQE60 vector places the B. burgdorferi protein coding region including its associated stop codon downstream from the IPTG-inducible promoter and in-frame with an initiating AUG. The associated stop codon prevents translation of the six histidine codons downstream of the insertion point.

The ligation mixture is transformed into competent E. coli cells using standard procedures such as those described by Sambrook et al. E. coli strain M15/rep4, containing multiple copies of the plasmid pREP4, which expresses the lac repressor and confers kanamycin resistance (“Kanr”), is used in carrying out the illustrative example described herein. This strain, which is only one of many that are suitable for expressing B. burgdorferi polypeptide, is available commercially (QIAGEN, Inc., supra). Transformants are identified by their ability to grow on LB plates in the presence of ampicillin and kanamycin. Plasmid DNA is isolated from resistant colonies and the identity of the cloned DNA confirmed by restriction analysis, PCR and DNA sequencing.

Clones containing the desired constructs are grown overnight (“O/N”) in liquid culture in LB media supplemented with both ampicillin (100 μg/ml) and kanamycin (25 μg/ml). The O/N culture is used to inoculate a large culture, at a dilution of approximately 1:25 to 1:250. The cells are grown to an optical density at 600 nm (“OD600”) of between 0.4 and 0.6 isopropyl-b-D-thiogalactopyranoside (“IPTG”) is then added to a final concentration of 1 mM to induce transcription from the lac repressor sensitive promoter, by inactivating the lacI repressor. Cells subsequently are incubated further for 3 to 4 hours. Cells then are harvested by centrifugation.

To purify the B. burgdorferi polypeptide, the cells are then stirred for 3-4 hours at 4° C. in 6M guanidine-HCl, pH 8. The cell debris is removed by centrifugation, and the supernatant containing the B. burgdorferi polypeptide is dialyzed against 50 mM Na-acetate buffer pH 6, supplemented with 200 mM NaCl. Alternatively, the protein can be successfully refolded by dialyzing it against 500 mM NaCl, 20% glycerol, 25 mM Tris/HCl pH 7.4, containing protease inhibitors. After renaturation the protein can be purified by ion exchange, hydrophobic interaction and size exclusion chromatography. Alternatively, an affinity chromatography step such as an antibody column can be used to obtain pure B. burgdorferi polypeptide. The purified protein is stored at 4° C. or frozen at −80° C.

The following alternative method may be used to purify B. burgdorferi polypeptides expressed in E. coli when it is present in the form of inclusion bodies. Unless otherwise specified, all of the following steps are conducted at 4-10° C.

Upon completion of the production phase of the E. coli fermentation, the cell culture is cooled to 4-10° C. and the cells are harvested by continuous centrifugation at 15,000 rpm (Heraeus Sepatech). On the basis of the expected yield of protein per unit weight of cell paste and the amount of purified protein required, an appropriate amount of cell paste, by weight, is suspended in a buffer solution containing 100 mM Tris, 50 mM EDTA, pH 7.4. The cells are dispersed to a homogeneous suspension using a high shear mixer.

The cells ware then lysed by passing the solution through a microfluidizer (Microfuidics, Corp. or APV Gaulin, Inc.) twice at 4000-6000 psi. The homogenate is then mixed with NaCl solution to a final concentration of 0.5 M NaCl, followed by centrifugation at 7000×g for 15 min. The resultant pellet is washed again using 0.5M NaCl, 100 mM Tris, 50 mM EDTA, pH 7.4.

The resulting washed inclusion bodies are solubilized with 1.5 M guanidine hydrochloride (GuHCl) for 2-4 hours. After 7000×g centrifugation for 15 min., the pellet is discarded and the B. burgdorferi polypeptide-containing supernatant is incubated at 4° C. overnight to allow further GuHCl extraction.

Following high speed centrifugation (30,000×g) to remove insoluble particles, the GuHCl solubilized protein is refolded by quickly mixing the GuHCl extract with 20 volumes of buffer containing 50 mM sodium, pH 4.5, 150 mM NaCl, 2 mM EDTA by vigorous stirring. The refolded diluted protein solution is kept at 4° C. without mixing for 12 hours prior to further purification steps.

To clarify the refolded B. burgdorferi polypeptide solution, a previously prepared tangential filtration unit equipped with 0.16 μm membrane filter with appropriate surface area (e.g., Filtron), equilibrated with 40 mM sodium acetate, pH 6.0 is employed. The filtered sample is loaded onto a cation exchange resin (e.g., Poros HS-50, Perspective Biosystems). The column is washed with 40 mM sodium acetate, pH 6.0 and eluted with 250 mM, 500 mM, 1000 mM, and 1500 mM NaCl in the same buffer, in a stepwise manner. The absorbance at 280 mm of the effluent is continuously monitored. Fractions are collected and further analyzed by SDS-PAGE.

Fractions containing the B. burgdorferi polypeptide are then pooled and mixed with 4 volumes of water. The diluted sample is then loaded onto a previously prepared set of tandem columns of strong anion (Poros HQ-50, Perspective Biosystems) and weak anion (Poros CM-20, Perspective Biosystems) exchange resins. The columns are equilibrated with 40 mM sodium acetate, pH 6.0. Both columns are washed with 40 mM sodium acetate, pH 6.0, 200 mM NaCl. The CM-20 column is then eluted using a 10 column volume linear gradient ranging from 0.2 M NaCl, 50 mM sodium acetate, pH 6.0 to 1.0 M NaCl, 50 mM sodium acetate, pH 6.5. Fractions are collected under constant A₂₈₀ monitoring of the effluent. Fractions containing the B. burgdorferi polypeptide (determined, for instance, by 16% SDS-PAGE) are then pooled.

The resultant B. burgdorferi polypeptide exhibits greater than 95% purity after the above refolding and purification steps. No major contaminant bands are observed from Commassie blue stained 16% SDS-PAGE gel when 5 μg of purified protein is loaded. The purified protein is also tested for endotoxin/LPS contamination, and typically the LPS content is less than 0.1 ng/ml according to LAL assays.

3(d). Cloning and Expression of B. burgdorferi in Other Bacteria

B. burgdorferi polypeptides can also be produced in: B. burgdorferi using the methods of S. Skinner et al., (1988) Mol. Microbiol. 2:289-297 or J. I. Moreno (1996) Protein Expr. Purif. 8(3):332-340; Lactobacillus using the methods of C. Rush et al., 1997 Appl. Microbiol. Biotechnol. 47(5):537-542; or in Bacillus subtilis using the methods Chang et al., U.S. Pat. No. 4,952,508.

4. Cloning and Expression in COS Cells

A B. burgdorferi expression plasmid is made by cloning a portion of the DNA encoding a B. burgdorferi polypeptide into the expression vector pDNAI/Amp or pDNAIII (which can be obtained from, Invitrogen, Inc.). The expression vector pDNAI/amp contains: (1) an E. coli origin of replication effective for propagation in E. coli and other prokaryotic cells; (2) an ampicillin resistance gene for selection of plasmid-containing prokaryotic cells; (3) an SV40 origin of replication for propagation in eukaryotic cells; (4) a CMV promoter, a polylinker, an SV40 intron; (5) several codons encoding a hemagglutinin fragment (i.e., an “HA” tag to facilitate purification) followed by a termination codon and polyadenylation signal arranged so that a DNA can be conveniently placed under expression control of the CMV promoter and operably linked to the SV40 intron and the polyadenylation signal by means of restriction sites in the polylinker. The HA tag corresponds to an epitope derived from the influenza hemagglutinin protein described by Wilson et al. 1984 Cell 37:767. The fusion of the HA tag to the target protein allows easy detection and recovery of the recombinant protein with an antibody that recognizes the HA epitope. pDNAIII contains, in addition, the selectable neomycin marker.

A DNA fragment encoding a B. burgdorferi polypeptide is cloned into the polylinker region of the vector so that recombinant protein expression is directed by the CMV promoter. The plasmid construction strategy is as follows. The DNA from a B. burgdorferi genomic DNA prep is amplified using primers that contain convenient restriction sites, much as described above for construction of vectors for expression of B. burgdorferi in E. coli. The 5′ primer contains a Kozak sequence, an AUG start codon, and nucleotides of the 5′ coding region of the B. burgdorferi polypeptide. The 3′ primer, contains nucleotides complementary to the 3′ coding sequence of the B. burgdorferi DNA, a stop codon, and a convenient restriction site.

The PCR amplified DNA fragment and the vector, pDNAI/Amp, are digested with appropriate restriction enzymes and then ligated. The ligation mixture is transformed into an appropriate E. coli strain such as SURE™ (Stratagene Cloning Systems, La Jolla, Calif. 92037), and the transformed culture is plated on ampicillin media plates which then are incubated to allow growth of ampicillin resistant colonies. Plasmid DNA is isolated from resistant colonies and examined by restriction analysis or other means for the presence of the fragment encoding the B. burgdorferi polypeptide.

For expression of a recombinant B. burgdorferi polypeptide, COS cells are transfected with an expression vector, as described above, using DEAE-dextran, as described, for instance, by Sambrook et al. (supra). Cells are incubated under conditions for expression of B. burgdorferi by the vector.

Expression of the B. burgdorferi-HA fusion protein is detected by radiolabeling and immunoprecipitation, using methods described in, for example Harlow et al., supra. To this end, two days after transfection, the cells are labeled by incubation in media containing ³⁵S-cysteine for 8 hours. The cells and the media are collected, and the cells are washed and the lysed with detergent-containing RIPA buffer: 150 mM NaCl, 1% NP-40, 0.1% SDS, 1% NP-40, 0.5% DOC, 50 mM TRIS, pH 7.5, as described by Wilson et al. (supra). Proteins are precipitated from the cell lysate and from the culture media using an HA-specific monoclonal antibody. The precipitated proteins then are analyzed by SDS-PAGE and autoradiography. An expression product of the expected size is seen in the cell lysate, which is not seen in negative controls.

5. Cloning and Expression in CHO Cells

The vector pC4 is used for the expression of B. burgdorferi polypeptide in this example. Plasmid pC4 is a derivative of the plasmid pSV2-dhfr (ATCC Accession No. 37146). The plasmid contains the mouse DHFR gene under control of the SV40 early promoter. Chinese hamster ovary cells or other cells lacking dihydrofolate activity that are transfected with these plasmids can be selected by growing the cells in a selective medium (alpha minus MEM, Life Technologies) supplemented with the chemotherapeutic agent methotrexate. The amplification of the DHFR genes in cells resistant to methotrexate (MTX) has been well documented. See, e.g., Alt et al., 1978, J. Biol. Chem. 253:1357-1370; Hamlin et al., 1990, Biochem. et Biophys. Acta, 1097:107-143; Page et al., 1991, Biotechnology 9:64-68. Cells grown in increasing concentrations of MTX develop resistance to the drug by overproducing the target enzyme, DHFR, as a result of amplification of the DHFR gene. If a second gene is linked to the DHFR gene, it is usually co-amplified and over-expressed. It is known in the art that this approach may be used to develop cell lines carrying more than 1,000 copies of the amplified gene(s). Subsequently, when the methotrexate is withdrawn, cell lines are obtained which contain the amplified gene integrated into one or more chromosome(s) of the host cell.

Plasmid pC4 contains the strong promoter of the long terminal repeat (LTR) of the Rouse Sarcoma Virus, for expressing a polypeptide of interest, Cullen, et al. (1985) Mol. Cell. Biol. 5:438-447; plus a fragment isolated from the enhancer of the immediate early gene of human cytomegalovirus (CMV), Boshart, et al., 1985, Cell 41:521-530. Downstream of the promoter are the following single restriction enzyme cleavage sites that allow the integration of the genes: Bam HI, Xba I, and Asp 718. Behind these cloning sites the plasmid contains the 3′ intron and polyadenylation site of the rat preproinsulin gene. Other high efficiency promoters can also be used for the expression, e.g., the human. β-actin promoter, the SV40 early or late promoters or the long terminal repeats from other retroviruses, e.g., HIV and HTLVI. Clontech's Tet-Off and Tet-On gene expression systems and similar systems can be used to express the B. burgdorferi polypeptide in a regulated way in mammalian cells (Gossen et al., 1992, Proc. Natl. Acad. Sci. USA 89:5547-5551. For the polyadenylation of the mRNA other signals, e.g., from the human growth hormone or globin genes can be used as well. Stable cell lines carrying a gene of interest integrated into the chromosomes can also be selected upon co-transfection with a selectable marker such as gpt, G418 or hygromycin. It is advantageous to use more than one selectable marker in the beginning, e.g., G418 plus methotrexate.

The plasmid pC4 is digested with the restriction enzymes and then dephosphorylated using calf intestinal phosphates by procedures known in the art. The vector is then isolated from a 1% agarose gel. The DNA sequence encoding the B. burgdorferi polypeptide is amplified using PCR oligonucleotide primers corresponding to the 5′ and 3′ sequences of the desired portion of the gene. A 5′ primer containing a restriction site, a Kozak sequence, an AUG start codon, and nucleotides of the 5′ coding region of the. B. burgdorferi polypeptide is synthesized and used. A 3′ primer, containing a restriction site, stop codon, and nucleotides complementary to the 3′ coding sequence of the B. burgdorferi polypeptides is synthesized and used. The amplified fragment is digested with the restriction endonucleases and then purified again on a 1% agarose gel. The isolated fragment and the dephosphorylated vector are then ligated with T4 DNA ligase. E. coli HB101 or XL-1 Blue cells are then transformed and bacteria are identified that contain the fragment inserted into plasmid pC4 using, for instance; restriction enzyme analysis.

Chinese hamster ovary cells lacking an active DHFR gene are used for transfection. Five μg of the expression plasmid pC4 is cotransfected with 0.5 μg of the plasmid pSV neo using a lipid-mediated transfection agent such as Lipofectin™ or LipofectAMINE™ (LifeTechnologies Gaithersburg, Md.). The plasmid pSV2-neo contains a dominant selectable marker, the neo gene from Tn5 encoding an enzyme that confers resistance to a group of antibiotics including G418. The cells are seeded in alpha minus MEM supplemented with 1 mg/ml G418. After 2 days, the cells are trypsinized and seeded in hybridoma cloning plates (Greiner, Germany) in alpha minus MEM supplemented with 10, 25, or 50 ng/ml of methotrexate plus 1 mg/ml G418. After about 10-14 days single clones are trypsinized and then seeded in 6-well petri dishes or 10 ml flasks using different concentrations of methotrexate (50 nM, 100 nM, 200 nM, 400 nM, 800 nM). Clones growing at the highest concentrations of methotrexate are then transferred to new 6-well plates containing even higher concentrations of methotrexate (1 μM, 2 μM, 5 μM, 10 mM, 20 mM). The same procedure is repeated until clones are obtained which grow at a concentration of 100-200 μM. Expression of the desired gene product is analyzed, for instance, by SDS-PAGE and Western blot or by reversed phase HPLC analysis.

6. Immunization and Detection of Immune Responses

6(a). B. burgdorferi Propagation

B. burgdorferi sensu stricto isolate B31 is propagated in tightly-closed containers at 34° C. in modified Barbour-Stoenner-Kelly (BSKII) medium (Barbour, A. G., Yale J. Biol. Med. 57:521-525 (1984)) overlaid with a 5% O₂/5% CO₂/90% N₂ gas mixture. Cell densities of these cultures are determined by darkfield microscopy at 400×.

Immunization of Mice and Challenge with B. burgdorferi. For active immunizations BALB/cByJ mice (BALB, Jackson Laboratories) are injected intraperitoneally (i.p.) at week 0 with 20 g of recombinant borrelial protein, or phosphate-buffered saline (PBS), emulsified with complete Freund's adjuvant (CFA), given a similar booster immunization in incomplete Freund's adjuvant (IFA) at week 4, and challenged at week 6. For challenge B. burgdorferi are diluted in BSKII from exponentially-growing cultures and mice are injected subcutaneously (s.c.) at the base of the tail with 0.1 ml of these dilutions (typically 10³-10⁴ borreliae; approximately 10-100 times the median infectious dose). Borreliae used for challenge are passaged fewer than six times in vitro. To assess infection, mice are sacrificed at 14-17 days post-challenge, and specimens derived from ear, bladder, and tibiotarsal joints are placed in BSKII plus 1.4% gelatin, 13 g/ml amphotericin B, 1.5 g/ml phosphomycin, and 15 g/ml rifampicin, and borrelia outgrowth at two or three weeks is quantified by darkfield microscopy. Batches of BSKII are qualified for infection testing by confirming that they supported the growth of 1-5 cells of isolate B31. In some instances seroconversion for protein P39 reactivity is also used to confirm infections (see below). Others have previously shown that mice elicited antibodies to P39 when inoculated with live borreliae by syringe or tick bite, but not with killed borreliae (Simpson, W. J., et al., J. Clin. Microbiol. 29:236-243 (1991)).

6(b). Immunoassays

Several immunoassay formats are used to quantify levels of borrelia-specific antibodies (ELISA and immunoblot), and to evaluate the functional properties of these antibodies (growth inhibition assay). The ELISA and immunoblot assays are also used to detect and quantify antibodies elicited in response to borrelial infection that react with specific borrelial antigens. Where antibodies to certain borrelial antigens are elicited by infection this is taken as evidence that the borrelial proteins in question are expressed in vivo. Absence of infection-derived antibodies (seroconversion) following borrelial challenge is evidence that infection is prevented or suppressed. The immunoblot assay is also used to ascertain whether antibodies raised against recombinant borrelial antigens recognize a protein of similar size in extracts of whole borreliae. Where the natural protein is of similar, or identical, size in the immunoblot assay to the recombinant version of the same protein, this is taken as evidence that the recombinant protein is the product of a full-length clone of the respective gene.

Enzyme-Linked Immunosorbant Assay (ELISA). The ELISA is used to quantify levels of antibodies reactive with borrelial antigens elicited in response to immunization with these borrelial antigens. Wells of 96 well microtiter plates (Immunlon 4, Dynatech, Chantilly, Va., or equivalent) are coated with antigen by incubating 50 l of 1 g/ml protein antigen solution in a suitable buffer, typically 0.1 M sodium carbonate buffer at pH 9.6. After decanting unbound antigen, additional binding sites are blocked by incubating 100 l of 3% nonfat milk in wash buffer (PBS, 0.2% Tween 20, pH 7.4). After washing, duplicate serial two-fold dilutions of sera in PBS, Tween 20, 1% fetal bovine serum, are incubated for 1 hr, removed, wells are washed three times, and incubated with horseradish peroxidase-conjugated goat anti-mouse IgG. After three washes, bound antibodies are detected with H₂O₂ and 2,2′-azino-di-(3-ethylbenzthiazoline sulfonate) (Schwan, T. G., et al., Proc. Natl. Acad Sci. USA 92:2909-2913 (1985)) (ABTS®, Kirkegaard & Perry Labs., Gaithersburg, Md.) and A₄₀₅ is quantified with a Molecular Devices, Corp. (Menlo Park, Calif.) Vmax™ plate reader. IgG levels twice the background level in serum from naive mice are assigned the minimum titer of 1:100.

6(c). In Vitro Growth Inhibition Assay

Unlike other bacteria, borreliae can be killed by the binding of specific antibodies to their surface antigens. The mechanism for this in vitro killing or growth-inhibitory effect is not known, but can occur in the absence of serum complement, or other immune effector functions. Antibodies elicited in animals receiving immunizations with specific borrelial antigens that result in protection from borrelial challenge usually will directly kill borreliae in vitro. Thus, the in vitro growth inhibition assay also has a high predictive value for the protective potency of the borrelial antibodies, although exceptions, such as antibodies against OspC which are weak at in vitro growth inhibition, have been observed. Also, this assay can be used to evaluate the serologic conservation of epitope binding protective antibodies. A microwell antibody titration assay (Sadziene, A., et al., J. Infect. Dis. 167:165-172 (1993)) is used to evaluate the growth inhibition (GI) properties of antisera against recombinant borrelial antigens against the homologous B31 isolate, and against various strains of borrelia. Briefly, 10⁵ borrelia in 100 l BSKII are added to serial two-fold dilutions of sera in 100 l BSKII in 96-well plates, and the plates are covered and incubated at 34° C. in a 5% O₂/5% CO₂/90% N₂ gas mixture for 72 h prior to quantification of borrelia growth by darkfield microscopy.

6(d). Sodiumdodecylsulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) and Immunoblotting

Using a single well format, total borrelial protein extracts, recombinant borrelial antigen, or recombinant P39 samples (2 g of purified protein, or more for total borrelial extracts) are boiled in SDS/2-ME sample buffer before electrophoresis through 3% acrylamide stacking gels, and resolving gels of higher acrylamide concentration, typically 10-15% acrylamide monomer. Gels are electro-blotted to nitrocellulose membranes and lanes are probed with dilutions of antibody to be tested for reactivity with specific borrelial antigens, followed by the appropriate secondary antibody-enzyme (horseradish peroxidase) conjugate. When it is desirable to confirm that the protein had transferred following electro-blotting, membranes are stained with Ponceau S. Immunoblot signals from bound antibodies are detected on x-ray film as chemiluminescence using ECL™ reagents (Amersham Corp., Arlington Heights, Ill.).

6(e). Detection of Borrelia mRNA Expression

Northern blot analysis is carried out using methods described by, among others, Sambrook et al., supra. to detect the expression of the B. burgdorferi nucleotide sequences of the present invention in animal tissues. A cDNA probe containing an entire nucleotide sequence shown in Table 1 is labeled with ³²P using the rediprime™ DNA labeling system (Amersham Life Science), according to manufacturer's instructions. After labeling, the probe is purified using a CHROMA SPIN-100™ column (Clontech Laboratories, Inc.), according to manufacturer's protocol number PT1200-1. The purified labeled probe is then used to detect the expression of Borrelia mRNA in an animal tissue sample.

Animal tissues, such as blood or spinal fluid, are examined with the labeled probe using ExpressHyb™ hybridization solution (Clontech) according to manufacturer's protocol number PT1190-1. Following hybridization and washing, the blots are mounted and exposed to film at −70 C overnight, and films developed according to standard procedures.

The disclosure of all publications (including patents, patent applications, journal articles, laboratory manuals, books, or other documents) cited herein are hereby incorporated by reference in their entireties.

Thee present invention is not to be limited in scope by the specific embodiments described herein, which are intended as single illustrations of individual aspects of the invention. Functionally equivalent methods and components are within the scope of the invention, in addition to those shown and described herein and will become apparant to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.

Provisional Application Ser. No. 60/057,483 filed 3 Sep. 1997 is incorporated by reference herein in its entirety.

TABLE 1 Nucleotide and Amino Acid Sequences. f101.aa (SEQ ID NO:1) MSKIFLLFNAGFFFLKIIYVFSYPEIKNFSRQDPVFSDLKIKVLKYNKKQHIPLFFYSYKVKKGDTFFKI ANKINGWQSGIATINLLDSPAVSVGQEILIPSKKGVFVFDSKDYRFNNLLLATRDLAKAEKVKIKRN DRVYEFYFFDFVKNPDFGLFSGTELLFFLNANFIFPLKKFIVSSDFGFRNDPFTGNKSFHTGIDLAAPM NAEVYLLLLE t101.aa (SEQ ID NO:2) SYPEIKNFSRQDPVFSDLKIKVLKYNKKQHIPLFFYSYKVKKGDTFFKIANKINGWQSGIATINLLDSP AVSVGQEILIPSKKGVFVFDSKDYRFNNLLLATRDLAKAEKVKIKRNDRVYEFYFFDFVKNPDFGLF SGTELLFFLNANFIFPLKKFIVSSDFGFRNDPFTGNKSFHTGIDLAAPMNAEVYLLLLE f101.nt (SEQ ID NO:3) ATGAGTAAAATTTTTTTATTATTTAATGCAGGTTTCTTTTTTTTAAAAATAATTTATGTTTTTTCT TATCCAGAAATAAAAAATTTCTCAAGGCAAGATCCTGTTTTTTCTGATCTTAAAATTAAAGTTTT AAAATATAACAAAAAACAACATATTCCTCTGTTTTTTTACTCATATAAAGTTAAAAAAGGGGAT ACTTTTTTTAAAATTGCCAATAAAATAAATGGATGGCAGTCCGGCATTGCTACTATTAATTTATT AGATTCTCCTGCTGTGAGTGTTGGGCAAGAGATTCTTATTCCCAGTAAAAAAGGAGTTTTTGTT TTTGATAGTAAAGATTATAGATTTAATAATTTGCTTTTAGCAACAAGGGATCTTGCTAAAGCTG AAAAGGTAAAAATTAAAAGGAACGACAGAGTTTATGAATTTTATTTTTTTGATTTTGTTAAGAA TCCAGATTTTGGACTTTTTTCAGGCACAGAATTGCTTTTTTTCTTAAATGCCAATTTTATTTTTCC TTTAAAAAAATTTATTGTTAGTTCTGATTTTGGATTTAGAAATGACCCTTTCACTGGCAACAAAA GTTTCCATACAGGAATAGATCTTGCAGCTCCAATGAATGCTGAAGTGTATCTTCTTCTTCTGGA ATAG t101.nt (SEQ ID NO:4) TCTTATCCAGAAATAAAAAATTTCTCAAGGCAAGATCCTGTTTTTTCTGATCTTAAAATTAAAGT TTTAAAATATAACAAAAAACAACATATTCCTCTGTTTTTTTACTCATATAAAGTTAAAAAAGGG GATACTTTTTTTAAAATTGCCAATAAAATAAATGGATGGCAGTCCGGCATTGCTACTATTAATT TATTAGATTCTCCTGCTGTGAGTGTTGGGCAAGAGATTCTTATTCCCAGTAAAAAAGGAGTTTT TGTTTTTGATAGTAAAGATTATAGATTTAATAATTTGCTTTTAGCAACAAGGGATCTTGCTAAA GCTGAAAAGGTAAAAATTAAAAGGAACGACAGAGTTTATGAATTTTATTTTTTTGATTTTGTTA AGAATCCAGATTTTGGACTTTTTTCAGGCACAGAATTGCTTTTTTTCTTAAATGCCAATTTTATT TTTCCTTTAAAAAAATTTATTGTTAGTTCTGATTTTGGATTTAGAAATGACCCTTTCACTGGCAA CAAAAGTTTCCATACAGGAATAGATCTTGCAGCTCCAATGAATGCTGAAGTGTATCTTCTTCTT CTGGAATAG f11.aa (SEQ ID NO:5) VKKYIKTIFLISMVYFYCCTTIKINHDYETDFKVLESPSKYINIDVIKATNEYIYIQITNNSLDVVKINW QNTSLNNDKIVLKKEDLTINNETGYKNKYREFFIGPKTSFKFKVYPLKIHSKNKNSNNLSSTIKYPSIF KLNITKVGIEAKKTINVLITRTTKINITNK t11.aa (SEQ ID NO:6) CCTTIKINHDYETDFKVLESPSKYINIDVIKATNEYIYIQITNNSLDVVKINWQNTSLNNDKIVLKKED LTINNETGYKNKYREFFIGPKTSFKFKVYPLKIHSKNKNSNNLSSTIKYPSIFKLNITKVGIEAKKTINV LITRTTKINITNK f11.nt (SEQ ID NO:7) GTGGAAAAATTTCTTTTATTCCAGGAAATGAAAATATTGCAGATCTTGGTTTTCATAAAACTAA GTAGAAATATTGTCAAAAAATACATAAAAACAATATTTCTGATTTCAATGGTTTATTTTTATTGT TGTACGACAATAAAAATAAACCATGATTATGAAACTGATTTTAAAGTTCTAGAATCTCCCTCTA AATACATCAATATAGATGTAATTAAAGCTACAAATGAATATATTTATATTCAAATTACAAACAA TAGCTTAGACGTAGTAAAAATAAATTGGCAAAACACTAGTCTTAACAACGATAAGATCGTCTTA AAAAAAGAAGATCTTACAATAAACAATGAAACAGGGTATAAAAATAAATACAGAGAGTTTTTT ATTGGTCCTAAAACTTCATTTAAATTTAAAGTATATCCACTAAAAATTCATTCTAAAAACAAAA ATAGCAATAACTTAAGCTCAACTATTAAATATCCGTCTATTTTTAAGCTCAACATAACAAAAGT AGGAATTGAAGCAAAAAAAACAATAAATGTTTTAATAACAAGAACTACAAAAATTAATATTAC TAATAAATGA t11.nt (SEQ ID NO:8) TGTTGTACGACAATAAAAATAAACCATGATTATGAAACTGATTTTAAAGTTCTAGAATCTCCCT CTAAATACATCAATATAGATGTAATTAAAGCTACAAATGAATATATTTATATTCAAATTACAAA CAATAGCTTAGACGTAGTAAAAATAAATTGGCAAAACACTAGTCTTAACAACGATAAGATCGTC TTAAAAAAAGAAGATCTTACAATAAACAATGAAACAGGGTATAAAAATAAATACAGAGAGTTT TTTATTGGTCCTAAACTTCATTTAAATTTAAAGTATATCCACTAAAAATTCATTCTAAAAACAA AAATAGCAATAACTTAAGCTCAACTATTAAATATCCGTCTATTTTTAAGCTCAACATAACAAAA GTAGGAATTGAAGCAAAAAAAACAATAAATGTTTTAATAACAAGAACTACAAAAATTAATATT ACTAATAAATGA f12.aa (SEQ ID NO:9) MREFLYRNVFKKSFIVFLIFLTFSNAIFAQTIDDENSKKRDKLTLSQKSYLRELELSTDEDLKKWALK EGLKETDVSKIRELLLKKFGIDPELFIKGKGLAGSGRYKIIIETADNLENFTYGLTKDESIIFEGRVNIL VEDIKENKKHNIKGDRIVLNKNSKKLYAIGNVEYILDMDTNEKLYFYGNEFLVDFDSQNFLLKNGIL QKKMQKNQIDHILSFGGKVLKKIDNDVTILEQAFATTSKIPEPYYSIKASKIWALPSGDFGFLNAIFY MGRVPVFYIPFFFRPGDSLFFNPSLGLNPRKGFSVFNTVYLFGNKSSSEDSSFLDFDFNSVYNSGKKP YIRNGYLTYFFAENLAPSVNKDYVKLIFDIYANLGFYSGIDFNLGNTLGHFKTLEGNFGLGFTRNVY SYDGGYYPFDNRTLKQSLFSFSNLNKGDVFGFEVPFRYLFKFKTEFLLSDALFSVVLEHYSDPYVNID FRDRIESATFFSLLNLDKDSVKEQTSISTFDWNLSSFYKRTFNDGSILDYKLNNLGLSFKLSGYENLY VKSPLEKPKDVNDPTRKWFYLERIYAPYIDLNFQKDLYNNQWTFPADTKEMIMRPEIKNLEDKDND KKSVKEKNTKKTTELTKDLYIPPEPITLKNIDQSDSFFIRFGINPYLRNNVFFDNYGITSPKDFNYEIKN YLFDIKNKTDIKIHADFYNRLITFENLLYLNTIEYSPLNKDFKVEDKDKKSEHSIINQINLNLLPFTIYP LFSRSTLKFENKATLYSFNKKYDSDVKSLVNKNSSIFLSDPETFYQSLTASLIYDYDYFTTELSGELK NSFEDIKASSELKLSLDFPYLLQEAGIGIKYYKKFKEDAMKNSGISAVQSPLEPQKPSSPYKNLEMSP ALYYKIEPRYLDYFKFSFLVAYDPLINRVSELSFKLNVFDFQFLFAMKDDFEYNYDPLKGDFSKIGTT TKLVPYSLDSSYKKELYVLTFFDNKLSFTLGVDVGWKINLQKFTDNELRSALTLKFKYTEFLEIYFST LSNTKIFKYFKGYMDQIGLEPVNFFVDLSKSFNFFNSQDRKDSLFKIKKFSSGFKFNFYDWKFVGE YNLEPDLLRGSDGIYSPIWRNNFTIYISWNFFAPIKASFENNKDTNYEFIINRKTKK t12.aa (SEQ ID NO:10) IFAQTIDDENSKKRDKLTLSQKSYLRELELSTDEDLKKWALKEGLKETDVSKIRELLLKKFGIDPELFI KGKGLAGSGRYKIIIETADNLENFTYGLTKDESIIFEGRVNILVEDIKENKKHNIKGDRIVLNKNSKKL YAIGNVEYILDMDTNEIKLYFYGNEFLVDFDSQNFLLKNGILQKKMQKNQIDHILSFGGKVLKKIDN DVTILEQAFATTSKIPEPYYSIKASKIWALPSGDFGFLNAIFYMGRVPVFYIPFFFRPGDSLFFNPSLGL NPRKGPSVFNTVYLFGNKSSSEDSSFLDFDFNSVYNSGKKPYIRNGYLTYFFAENLAPSVNKDYVKL IFDIYANLGFYSGIDFNLGNTLGHFKTLEGNFGLGFTRNVYSYDGGYYPFDNRTLKQSLFSFSNLNK GDVFGFEVPFRYLFKFKTEFLLSDALFSVVLEHYSDPYVNIDFRDRIESATFFSLLNLDKDSVKEQTSI STFDWNLSSFYKRTFNDGSILDYKLNNLGLSFKLSGYENLYVKSPLEKPKDVNDPTRKWFYLERIYA PYIDLNFQKDLYNNQWTFPADTKEMIMRPEIKNLEDKDNDKKSVKEKNTKKTTELTKDLYIPPEPIT LKNIDQSDSFFIRFGINPYLRNNVFFDNYGITSPKDFNYEIKNYLFDIKNKTDIKIHADFYNRLITFENL LYLNTIEYSPLNKDFKVEDKDKKSEHSIINQINLNLLPFIRYPLFSRSTLKFENKATLYSFNKKYDSDV KSLVNKNSSIFLSDPETFYQSLTASLIYDYDYFTTELSGELKNSFEDIKASSELKLSLDFPYLLQEAGIG IKYYKKFKEDAMKNSGISAVQSPLEPQKPSSPYKNLEMSPALYYKIEPRYLDYFKFSFLVAYDPLINR VSELSFKLNVFDFQFLFAMKDDFEYNYDPLKGDFSKIGTTTKLVPYSLDSSYKKELYVLTFFDNKLS FTLGVDVGWKINLQKFTDNELRSALTLKFKYTEFLEIYFSTLSINTKTFKYFKGYMDQIGLEPVNFFV DLSKSFNFFNSQDRKDSLFKIKKFSSGFKFNFYDWKFVGEYNLEPDLLRGSDGIYSPIWRNNFTIYIS WNFFAPIKASFENNKDTNYEFIINRKTKK f12.nt (SEQ ID NO:11) ATGCGAGAATTCCTATACAGGAATGTTTTTAAAAAATCTTTTATAGTATTTTTAATTTTTTTAAC ATTTTCTAATGCAATTTTTGCCCAGACTATAGATGATGAAAATTCTAAAAAAAGGGATAAGCTA ACTTTAAGTCAAAAATCTTATTTAAGAGAACTTGAGCTTTCAACCGATGAGGATTTAAAAAAAT GGGCCTTAAAAGAGGGTTTAAAAGAAACAGATGTTTCAAAAATACGAGAATTGCTTTTAAAAA AGTTTGGAATAGATCCTGAGCTTTTTATCAAAGGAAAGGGACTTGCCGGATCTGGTAGATATAA AATAATCATTGAAACTGCAGATAATCTTGAAAATTTCACTTATGGACTTACTAAAGATGAAAGT ATTATTTTTGAAGGAAGAGTTAATATCTTGGTTGAAGATATTAAAGAAAATAAAAAGCACAATA TTAAAGGCGACAGAATAGTCCTTAATAAGAACTCTAAAAAACTTTATGCTATTGGAAATGTTGA ATATATTCTTGATATGGATACCAATGAAAAGCTTTATTTTTATGGCAATGAATTTCTTGTCGATT TTGATTCTCAAAATTTTTTATTAAAAAATGGTATTCTTCAAAAAAAAATGCAAAAAAATCAAAT AGATCATATTCTTTCGTTTGGAGGAAAGGTTTTAAAAAAGATAGACAATGATGTTACCATTTTG GAACAAGCTTTTGCAACAACTAGTAAAATTCCAGAGCCTTACTATTCAATCAAGGCTTCTAAAA TATGGGCATTGCCCTCGGGAGATTTTGGGTTTTTAAATGCCATATTTTACATGGGAAGAGTTCC AGTATTTTATATTCCTTTTTTTTTCCAGACCGGGAGATAGTTTGTTTTTTAATCCATCTTTAGGTCT AAATCCACGAAAAGGTTTTTCTGTTTTTAATACCGTTTATCTTTTTGGTAATAAATCTTCAAGTG AAGATTCTTCTTTTTTGGATTTTGATTTCAATTCTGTTTATAATTCGGGTAAAAAACCTTATATA AGAAATGGATATTTAACTTATTTTTTTGCAGAAAATTTAGCACCCAGTGTTAATAAAGATTATG TTAAGCTTATTTTTGACATTTATGCTAATCTGGGATTTTATTCTGGAATTGATTTTAATTTGGGC AATACTTTGGGGCATTTTAAAACTTTGGAAGGAAATTTTGGATTGGGTTTTACCAGGAATGTTT ATAGTTACGATGGAGGATATTATCCTTTTGATAATAGGACTTTAAAACAATCTCTTTTTAGTTTT TCCAATCTTAACAAAGGAGATGTATTTGGGTTTGAAGTTCCTTTTAGATATTTATTTAAATTTAA AACAGAATTTCTTTTAAGTGATGCACTTTTCTCGGTTGTTTTAGAGCACTATTCTGACCCGTATG TTAATATTGATTTTAGAGATAGGATAGAAAGTGCTACATTTTTTTCTCTTTTAAATTTAGATAAA GATTCGGTTAAAGAGCAAACTAGCATTAGCACTTTTGATTGGAATTTATCTTCTTTTTATAAGCG AACATTTAATGACGGTTCGATTTTAGATTATAAATTAAATAATTTAGGTTTAAGTTTTAAATTGT CGGGCTATGAAAATCTTTATGTTAAATCTCCTTTAGAGAAACCAAAAGATGTTAATGATCCTAC AAGAAAATGGTTTTATTTGGAGAGAATTTATGCTCCATATATTGATTTGAATTTTCAAAAAGAT CTTTACAATAACCAATGGACATTTCCAGCTGATACTAAAGAAATGATAATGCGCCCAGAAATTA AAAATCTAGAAGATAAAGATAATGATAAAAAGAGTGTGAAGGAGAAAAATACTAAAAAAACA ACAGAATTAACCAAAGATTTATATATTCCTCCAGAACCAATTACTTTAAAAAATATTGATCAAT CCGATTCTTTTTTTATTAGGTTTGGCATTAATCCTTATTTAAGAAATAATGTTTTTTTTGATAATT ATGGCATAACAAGTCCAAAGGACTTTAATTATGAAATAAAAAATTATTTATTTGATATAAAAAA TAAAACGGATATAAAAATTCATGCTGATTTTTACAATCGTTTAATTACTTTTGAAAATTTATTAT ATCTTAATACTATTGAGTATAGTCCTTTAAATAAAGATTTTAAAGTTGAAGATAAAGATAAAAA AAGTGAGCACTCTATTATTAACCAAATAAATTTAAACTTGCTTCCTTTTATTAGATATCCTTTAT TTTCTAGAAGTACTTTAAAGTTTGAAAATAAGGCTACTTTATATTCATTTAATAAAAATATGA TTCTGATGTAAAATCTTTGGTTAATAAGAATAGTAGTATTTTTTTATCTGATCCGGAAACTTTTT ATCAAAGTTTAACAGCCTCTTTAATTTATGATTATGATTATTTTACTACTGAGCTTTCAGGTGAA TTAAAAAATAGTTTTGAAGATATTAAAGCTTCTTCTGAGCTTAAACTTTCTTTAGATTTTCCTTA TTTGCTACAAGAAGCTGGGATTGGAATTAAATATTATAAAAAGTTTAAAGAAGATGCTATGAA AAACTCTGGAATTTCTGCTGTTCAAAGTCCTTTGGAGCCTCAAAAACCATCATCGCCCTTATAAA AATTTAGAAATGTCTCCTGCTTTGTATTATAAAATTGAGCCGAGATATTTGGATTATTTTAAATT TAGTTTTTTAGTCGCCTATGATCCTTTGATAAATAGAGTTTCTGAACTTTCTTTTAAGCTTAATG TTTTTGATTTTCAATTTTTGTTTGCTATGAAAGACGACTTTGAATATAATTATGATCCTTTAAAA GGAGATTTTTCCAAGATTGGTACTACAACCAAACTTGTTCCATATTCTTTAGATTCTAGTTACAA AAAGGAATTGTACGTTTTAACTTTTTTTGACAATAAGCTTTCTTTTACCTTGGGGGTAGATGTTG GTTGGAAAATAAATTTGCAGAAATTTACGGATAATGAACTTCGATCTGCATTGACTTTGAAGTT TAAATATACAGAATTTTTAGAAATTTACTTTTCTACTTTATCTATTAATACTAAGACTTTTAAAT ATTTTAAAGGGTATATGGACCAAATTGGTCTAGAACCTGTTAATTTCTTTGTTGATTTATCAAAA TCTTTCAATTTCTTTAATTCTCAAGACAGAAAAGATTCACTTTTTAAAATTAAAAAATTTTCATC AGGCTTTAAATTCAATTTTTATGATTGGAAATTTGTTGGAGAATATAATTTAGAACCAGATTTA TTAAGGGGATCTGATGGGATTTATTCTCCTATTTGGAGAAATAATTTTACAATTTATATTTCTTG GAACTTTTTTGCTCCTATAAAAGCGTCATTTGAAAACAACAAAGATACAAACTACGAGTTTATT ATTAATAGAAAAACAAAAAAATAA t12.nt (SEQ ID NO:12) ATTTTTGCCCAGACTATAGATGATGAAAATTCTAAAAAAAGGGATAAGCTAACTTTAAGTCAAA AATCTTATTTAAGAGAACTTGAGCTTTCAACCGATGAGGATTTAAAAAAATGGGCCTTAAAAGA GGGTTTAAAAGAAACAGATGTTTCAAAAATACGAGAATTGCTTTTAAAAAAGTTTGGAATAGA TCCTGAGCTTTTTATCAAAGGAAAGGGACTTGCCGGATCTGGTAGATATAAAATAATCATTGAA ACTGCAGATAATCTTGAAAATTTCACTTATGGACTTACTAAAGATGAAAGTATTATTTTTGAAG GAAGAGTTAATATCTTGGTTGAAGATATTAAAGAAAATAAAAAGCACAATATTAAAGGCGACA GAATAGTCCTTAATAAGAACTCTAAAAAACTTTATGCTATTGGAAATGTTGAATATATTCTTGA TATGGATACCAATGAAAAGCTTTATTTTTATGGCAATGAATTTCTTGTCGATTTTGATTCTCAAA ATTTTTTATTAAAAAATGGTATTCTTCAAAAAAAAATGCAAAAAAATCAAATAGATCATATTCT TTCGTTTGGAGGAAAGGTTTTAAAAAAGATAGACAATGATGTTACCATTTTGGAACAAGCTTTT GCAACAACTAGTAAAATTCCAGAGCCTTACTATTCAATCAAGGCTTCTAAAATATGGGCATTGC CCTCGGGAGATTTTGGGTTTTTAAATGCCATATTTTACATGGGAAGAGTTCCAGTATTTTATATT CCTTTTTTTTTCAGACCGGGAGATAGTTTGTTTTTTAATCCATCTTTAGGTCTAAATCCACGAAA AGGTTTTTCTGTTTTTAATACCGTTTATCTTTTTGGTAATAAATCTTCAAGTGAAGATTCTTCTTT TTTGGATTTTGATTTCAATTCTGTTTATAATTCGGGTAAAAAACCTTATATAAGAAATGGATATT TAACTTATTTTTTTGCAGAAAATTTAGCACCCAGTGTTAATAAAGATTATGTTAAGCTTATTTTT GACATTTATGCTAATCTGGGATTTTATTCTGGAATTGATTTTAATTTGGGCAATACTTTGGGGCA TTTTAAAACTTTGGAAGGAAATTTTGGATTGGGTTTTACCAGGAATGTTTATAGTTACGATGGA GGATATTATCCTTTTGATAATAGGACTTTAAAACAATCTCTTTTTAGTTTTTCCAATCTTAACAA AGGAGATGTATTTGGGTTTGAAGTTCCTTTTAGATATTTATTTAAATTTAAAACAGAATTTCTTT TAAGTGATGCACTTTTCTCGGTTGTTTTAGAGCACTATTCTGACCCGTATGTTAATATTGATTTT AGAGATAGGATAGAAAGTGCTACATTTTTTTCTCTTTTAAATTTAGATAAAGATTCGGTTAAAG AGCAAACTAGCATTAGCACTTTTGATTGGAATTTATCTTCTTTTTATAAGCGAACATTTAATGAC GGTTCGATTTTAGATTATAAATTAAATAATTTAGGTTTAAGTTTTAAATTGTCGGGCTATGAAA ATCTTTATGTTAAATCTCCTTTAGAGAAACCAAAAGATGTTAATGATCCTACAAGAAAATGGTT TTATTTGGAGAGAATTTATGCTCCATATATTGATTTGAATTTTCAAAAAGATCTTTACAATAACC AATGGACATTTCCAGCTGATACTAAAGAAATGATAATGCGCCCAGAAATTAAAAATCTAGAAG ATAAAGATAATGATAAAAAGAGTGTGAAGGAGAAAAATACTAAAAAAACAACAGAATTAACCA AAGATTTATATATTCCTCCAGAACCAATTACTTTAAAAAATATTGATCAATCCGATTCTTTTTTT ATTAGGTTTGGCATTAATCCTTATTTAAGAAATAATGTTTTTTTTGATAATTATGGCATAACAAG TCCAAAGGACTTTAATTATGAAATAAAAAATTATTTATTTGATATAAAAAATAAAACGGATATA AAAATTCATGCTGATTTTTACAATCGTTTAATTACTTTTGAAAATTTATTATATCTTAATACTAT TGAGTATAGTCCTTTAAATAAAGATTAAAGTTGAAGATAAAGATAAAAAAAGTGAGCACTCT ATTATTAACCAAATAAATTTAAACTTGCTTCCTTTTATTAGATATCCTTTATTTTCTAGAAGTAC TTTAAAGTTTGAAAATAAGGCTACTTATATTCATTTAATAAAAAATATGATTCTGATGTAAAA TCTTTGGTTAATAAGAATAGTAGTATTTTTTTATCTGATCCGGAAACTTTTTATCAAAGTTTAAC AGCCTCTTTAATTTATGATTATGATTATTTTACTACTGAGCTTTCAGGTGAATTAAAAAATAGTT TTGAAGATATTAAAGCTTCTTCTGAGCTTAAACTTTCTTTAGATTTTCCTTATTTGCTACAAGAA GCTGGGATTGGAATTAAATATTATAAAAAGTTTAAAGAAGATGCTATGAAAAACTCTGGAATTT CTGCTGTTCAAAGTCCTTTGGAGCCTCAAAAACCATCATCGCCTTATAAAAATTTAGAAATGTC TCCTGCTTTGTATTATAAAATTGAGCCGAGATATTTGGATTATTTTAAATTTAGTTTTTTAGTCG CCTATGATCCTTTGATAAATAGAGTTTCTGAACTTTCTTTTAAGCTTAATGTTTTTGATTTTCAA TTTTTGTTTGCTATGAAAGACGACTTTGAATATAATTATGATCCTTTAAAAGGAGATTTTTCCAA GATTGGTACTACAACCAAACTTGTTCCATATTCTTTAGATTCTAGTTACAAAAAGGAATTGTAC GTTTTAACTTTTTTTGACAATAAGCTTTCTTTTACCTTGGGGGTAGATGTTGGTTGGAAAATAAA TTTGCAGAAATTTACGGATAATGAACTTCGATCTGCATTGACTTTGAAGTTTAAATATACAGAA TTTTTAGAAATTTACTTTTCTACTTTATCTATTAATACTAAGACTTTTAAATATTTTAAAGGGTA TATGGACCAAATTGGTCTAGAACCTGTTAATTTCTTTGTTGATTTATCAAAATCTTTCAATTTCT TTAATTCTCAAGACAGAAAAGATTCACTTTTTAAAATTAAAAAATTTTCATCAGGCTTTAAATTC AATTTTTATGATTGGAAATTTGTTGGAGAATATAATTTAGAACCAGATTTATTAAGGGGATCTG ATGGGATTTATTCTCCTATTTGGAGAAATAATTTTACAATTTATATTTCTTGGAACTTTTTTGCT CCTATAAAAGCGTCATTTGAAAACAACAAAGATACAAACTACGAGTTTATTATTAATAGAAAAA CAAAAAAATAA f129.aa (SEQ ID NO:13) MTKKLFVRVLIFLISNNYAFAKDTIKDLFFIQDILIKKEKYSEVLNNASLEGIIEIEHNGPYIKDHDSEV KLILKENGYRRNFNFFNLLNTSNIIKSLSLFDSRPKNIKENEIILLETKMIKENPYKRYKDDDDFELKLS VTRKNNQIYLILDFNFLFDQRKTFPSIYIKEEDVSTIINSTMKLQDSSFLSPQAS t129.aa (SEQ ID NO:14) KDTIKDLFFIQDILIKKEKYSEVLNNASLEGIIEIEHNGPYIKDHDSEVKLILKENGYRRNFNFFNLLNT SNIIKSLSLFDSRPKNIKENEIILLETKMIKENPYKRYKDDDDFELKLSVTRKNNQIYLILDFNFLFDQR KTFPSIYIKEEDVSTIINSFMKLQDSSFLSPQAS f129.nt (SEQ ID NO:15) ATGACAAAAAAATTGTTTGTGAGGGTATTAATCTTTTTAATATCCAATAATTATGCTTTTGCAAA AGACACAATCAAAGATTTGTTCTTTATACAAGATATACTAATAAAAAAAGAGAAATATTCCGAG GTTCTAAATAATGCAAGCCTTGAAGGCATTATTGAAATTGAACATAACGGACCATACATTAAAG ATCACGATTCAGAAGTTAAACTTATCCTAAAAGAAAACGGATATAGAAGAAATTTCAACTTTTT TAATCTTTTAAATACTAGTAATATAATCAAAAGTCTAAGCTTATTTGACAGCAGACCAAAAAAC ATTAAAGAAAATGAAATCATATTATTAGAGACAAAAATGATTAAAGAAAATCCCTATAAACGA TACAAAGACGATGATGATTTTGAATTAAAACTAAGTGTAACTCGAAAAAATAATCAAATTTATT TAATTCTTGATTTCAATTTCCTATTTGATCAAAGAAAAACGTTTCCATCAATTTACATCAAAGAA GAAGATGTATCAACAATAATAAACAGCTTCATGAAACTACAAGATTCAAGCTTTTTATCTCCTC AAGCTTCTTAA t129.nt (SEQ ID NO:16) AAAGACACAATCAAAGATTTGTTCTTTATACAAGATATACTAATAAAAAAAGAGAAATATTCCG AGGTTCTAAATAATGCAAGCCTTGAAGGCATTATTGAAATTGAACATAACGGACCATACATTAA AGATCACGATTCAGAAGTTAAACTTATCCTAAAAGAAAACGGATATAGAAGAAATTTCAACTTT TTTAATCTTTTAAATACTAGTAATATAATCAAAAGTCTAAGCTTATTTGACAGCAGACCAAAAA ACATTAAAGAAAATGAAATCATATTATTAGAGACAAAAATGATTAAAGAAAATCCCTATAAAC GATACAAAGACGATGATGATTTTGAATTAAAACTAAGTGTAACTCGAAAAAATAATCAAATTTA TTTAATTCTTGATTTCAATTTCCTATTTGATCAAAGAAAAACGTTTCCATCAATTTACATCAAAG AAGAAGATGTATCAACAATAATAAACAGCTTCATGAAACTACAAGATTCAAGCTTTTTATCTCC TCAAGCTTCTTAA f142.aa (SEQ ID NO:17) MDKISILYTLINIIIMLILISIVYLCKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSEITNETINWISILG DGYVRLLKMIIIPLIITSIISAIIKLTNSKDVGKMSLLVILTLVFTAGIAAIIGIFTALALGLTAEGLQAGTI EILQSEKLQKGLEILNQTTITKKITDLIPQNIFEDFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFK KIILTLQDIILGVVTLILKLTPYAILALMTKITATSEIKSIIKLGETVIASYIAIGLTFLMHMTLIAINKLNP ITFIKKIFPALSFAFISRSSAATIPINIEIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIMIAPT QGINPTDISFILTLIGLIIITSFGAAGAGGGATTASLMVLSAMNFPVGLVGLVISVEPIIDMGRTAVNVG GSMLAGVISAKQLKQFNHNIYNQKELVNK t142.aa (SEQ ID NO:18) CKRKNVSFTKRVFIALAIGIVFGMTIQYFYGTNSEITNETINWISILGDGYVRLLKMIIIPLIITSIISAIIK LTNSKDVGKMSLLVILTLVFTAGIAAIIGIFTALALGLTAEGLQAGTIEILQSEKLQKGLEILNQTTITK KITDLIPQNIFEDFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPESIEFFKKIILTLQDIILGVVTLILKLTPY AILALMTKITATSEIKSIIKLGEFVIASYIAIGLTFLMHMTLIAINKLNPITFIKKIFPALSFAFISRSSAATI PINIEIQTKNLGVSEGIANLSSSFGTSIGQNGCAALHPAMLAIMIAPTQGINPTDISFILTLIGLIIITSFGA AGAGGGATTASLMVLSAMNFPVGLVGLVISVEPIIDMGRTAVNVGGSMLAGVISAKQLKQFNHNIY NQKELVNK f142.nt (SEQ ID NO:19) TAAGAGGTAATAATGGATAAAATAAGTATATTATATACATTAATCAATATTATAATAATGCTTA TTCTAATAAGCATAGTTTATCTTTGTAAAAGAAAAAATGTTTCTTTTACAAAAAGAGTGTTTAT AGCGTTAGCAATCGGAATAGTATTTGGAATGACCATTCAATATTTTTATGGAACAAATTCAGAA ATAACAAACGAAACTATAAATTGGATAAGTATTTTGGGCGATGGATACGTAAGGCTCCTTAAAA TGATTATAATCCCCTTAATAATAACATCAATAATCTCTGCAATAATAAAACTAACCAATAGTAA AGATGTTGGGAAAATGAGCCTACTTGTAATATTAACACTAGTATTTACAGCAGGTATTGCTGCC ATAATTGGCATTTTCACTGCTTTAGCATTGGGATTAACAGCCGAAGGACTACAAGCGGGAACCA TCGAAATTTTACAAAGTGAAAAATTGCAAAAAGGCCTTGAAATATTAAATCAAACAACAATCAC AAAAAAAATCACAGATCTTATTCCACAAAATATATTTGAAGATTTTGCAGGGCTTAGAAAAAAC TCAACCATCGGGGTCGTGATATTTTCAGCTATCATAGGAATAGCCGCCCTTAAAACATCTATCA AAAAGCCAGAATCAATAGAATTTTTTAAAAAAATAATATTAACACTCCAAGACATAATATTAGG TGTAGTAACTTTGATTTTAAAACTAACGCCTTATGCTATATTAGCTTTAATGACAAAAATTACAG CAACCAGCGAAATCAAAAGCATAATAAAGCTTGGAGAATTTGTAATTGCTTCCTACATTGCCAT AGGTCTTACATTTCTTATGCATATGACATTAATTGCAATAAATAAATTAAACCCAATTACTTTTA TAAAAAAAATATTCCCAGCACTATCATTTGCATTCATATCTAGGTCGAGTGCTGCAACCATACC CATTAATATAGAAATTCAAACTAAAAATCTGGGAGTAAGCGAAGGAATAGCAAATTTATCAAG CTCCTTTGGAACATCAATTGGGCAAAATGGTTGTGCAGCACTACACCCCGCTATGCTTGCAATA ATGATAGCACCAACTCAGGGAATAAACCCCACAGATATTTCATTTATACTCACACTTATTGGAT TAATAATAATAACTTCATTTGGAGCTGCTGGCGCTGGTGGAGGCGCAACAACAGCCTCACTAAT GGTGCTCTCAGCAATGAACTTTCCAGTGGGATTGGTAGGACTTGTAATATCTGTTGAGCCTATA ATTGACATGGGAAGAACAGCTGTTAATGTAGGCGGCTCAATGCTTGCAGGCGTTATATCTGCTA AACAGCTCAAACAATTCAACCATAATATATACAACCAAAAAGAGCTTGTAAACAAATAA t142.nt (SEQ ID NO:20) TGTAAAAGAAAAAATGTTTCTTTTACAAAAAGAGTGTTTATAGCGTTAGCAATCGGAATAGTAT TTGGAATGACCATTCAATATTTTTATGGAACAAATTCAGAAATAACAAACGAAACTATAAATTG GATAAGTATTTTGGGCGATGGATACGTAAGGCTCCTTAAAATGATTATAATCCCCTTAATAATA ACATCAATAATCTCTGCAATAATAAAACTAACCAATAGTAAAGATGTTGGGAAAATGAGCCTAC TTGTAATATTAACACTAGTATTTACAGCAGGTATTGCTGCCATAATTGGCATTTTCACTGCTTTA GCATTGGGATTAACAGCCGAAGGACTACAAGCGGGAACCATCGAAATTTTACAAAGTGAAAAA TTGCAAAAAGGCCTTGAAATATTAAATCAAACAACAATCACAAAAAAAATCACAGATCTTATTC CACAAAATATATTTGAAGATTTTGCAGGGCTTAGAAAAAACTCAACCATCGGGGTCGTGATATT TTCAGCTATCATAGGAATAGCCGCCCTTAAAACATCTATCAAAAAGCCAGAATCAATAGAATTT TTTAAAAAAATAATATTAACACTCCAAGACATAATATTAGGTGTAGTAACTTTGATTTTAAAAC TAACGCCTTATGCTATATTAGCTTTAATGACAAAAATTACAGCAACCAGCGAAATCAAAAGCAT AATAAAGCTTGGAGAATTTGTAATTGCTTCCTACATTGCCATAGGTCTTACATTTCTTATGCATA TGACATTAATTGCAATAAATAAATTAAACCCAATTACTTTTATAAAAAAAATATTCCCAGCACT ATCATTTGCATTCATATCTAGGTCGAGTGCTGCAACCATACCCATTAATATAGAAATTCAAACT AAAAATCTGGGAGTAAGCGAAGGAATAGCAAATTTATCAAGCTCCTTTGGAACATCAATTGGG CAAAATGGTTGTGCAGCACTACACCCCGCTATGCTTGCAATAATGATAGCACCAACTCAGGGAA TAAACCCCACAGATATTTCATTTATACTCACACTTATTGGATTAATAATAATAACTTCATTTGGA GCTGCTGGCGCTGGTGGAGGCGCAACAACAGCCTCACTAATGGTGCTCTCAGCAATGAACTTTC CAGTGGGATTGGTAGGACTTGTAATATCTGTTGAGCCTATAATTGACATGGGAAGAACAGCTGT TAATGTAGGCGGCTCAATGCTTGCAGGCGTTATATCTGCTAAACAGCTCAAACAATTCAACCAT AATATATACAACCAAAAAGAGCTTGTAAACAAATAA f147.aa (SEQ ID NO:21) MKIIIIGGTSAGTSAAAKANRLNKKLDITIYEKTNIVSFGTCGLPYFVGGFFDNPNTMISRTQEEFEKT GISVKTNHEVIKVDAKNNTIVIKNQKTGTIFNNTYDQLMIATGAKPIIPPINNINLENFHTLKNLEDGQ KIKKLMDREEIKNIVIIGGGYIGIEMVEAAKNRKNVRLIQLDKHILIDSFDEEIVTIMEEELTKKGVN LHTNEFVKSLIGEKKAEGVVTNKNTYQADAVILATGIKPDTEFLENQLKTTKNGAIIVNEYGETSIKN IFSAGDCATIYNIVSKKNEYIPLATTANKLGRIVGENLAGNHTAFKGTLGSASIKILSLEAARTGLTEK DAKKLQIKYKTIFVKDKNHTNYYPGQEDLYIKLIYEENTKIILGAQAIGKNGAVIRIHALSIAIYSKLT TKELGMMDFSYSPPFSRTWDILNIAGNAAK t147.aa (SEQ ID NO:22) AAAKANRLNKKLDITIYEKTNIVSFGTCGLPYFVGGFFDNPNTMISRTQEEFEKTGISVKTNHEVIKV DAKNNTIVIKNQKTGTIFNNTYDQLMIATGAKPIIPINNINLENFHTLKNLEDGQKIKKLMDREEIKN IVIIGGGYIGIEMVEAAKNKRKNVRLIQLDKHILIDSFDEEIVTIMEEELTKKGVNLHTNEFVKSLIGE KKAEGVVTNKNTYQADAVILATGIKPDTEFLENQLKTTKNGAIIVNEYGETSIKNIFSAGDCATIYNI VSKKNEYIPLATTANKLGRIVGENLAGNHTAFKGTLGSASIKILSLEAARTGLTEKDAKKLQIKYKTI FVKDKNHTNYYPGQEDLYIKLIYEENTKIILGAQAIGKNGAVIRIHALSIAIYSKLTTKELGMMDFSY SPPFSRTWDILNIAGNAAK f147.nt (SEQ ID NO:23) ATGAAAATAATAATTATTGGGGGCACATCAGCAGGAACTAGTGCCGCAGCTAAAGCAAACCGC TTAAACAAAAAGCTAGACATTACTATCTATGAAAAAACAAATATTGTATCTTTTGGAACCTGTG GCCTGCCTTACTTTGTGGGGGGATTCTTTGACAACCCCAATACAATGATCTCAAGAACACAAGA AGAATTCGAAAAAACTGGAATCTCTGTTAAAACTAACCACGAAGTTATCAAAGTAGATGCAAA AAACAATACAATTGTAATAAAAAATCAAAAAACAGGAACCATTTTTAACAATACTTACGATCAA CTTATGATAGCAACTGGTGCAAAACCTATTATTCCACCAATCAATAATATCAATCTAGAAAATT TTCATACTCTGAAAAATTTAGAAGACGGTCAAAAAATAAAAAAATTAATGGATAGAGAAGAGA TTAAAAATATAGTGATAATTGGTGGTGGATACATTGGAATTGAAATGGTAGAAGCAGCAAAAA ATAAAAGAAAAAATGTAAGATTAATTCAACTAGATAAGCACATACTCATAGATTCCTTTGACGA AGAAATAGTCACAATAATGGAAGAAGAACTAACAAAAAAGGGGGTTAATCTTCATACAAATGA GTTTGTAAAAAGTTTAATAGGAGAAAAAAAGGCAGAAGGAGTAGTAACAAACAAAAATACTTA TCAAGCTGACGCTGTTATACTTGCTACCGGAATAAAACCTGACACTGAATTTTTAGAAAACCAG CTTAAAACTACTAAAAATGGAGCAATAATTGTAAATGAGTATGGCGAAACTAGCATAAAAAAT ATTTTTTCTGCAGGAGATTGTGCAACTATTTATAATATAGTAAGTAAAAAAAATGAATACATAC CCTTGGCAACAACAGCCAACAAACTTGGAAGAATAGTTGGTGAAAATTTAGCTGGGAATCATA CAGCATTTAAAGGCACATTGGGCTCAGCTTCAATTAAAATACTATCTTTAGAAGCTGCAAGAAC AGGACTTACAGAAAAAGATGCAAAAAAGCTCCAAATAAAATATAAAACGATTTTTGTAAAGGA CAAAAATCATACAAATTATTATCCAGGCCAAGAAGATCTTTATATTAAATTAATTTATGAGGAA AATACCAAAATAATCCTTGGGGCACAAGCAATAGGAAAAAATGGAGCCGTAATAAGAATTCAT GCTTTATCAATTGCAATCTATTCAAAACTTACAACAAAAGAGCTAGGGATGATGGATTTCTCAT ATTCCCCACCCTTCTCAAGAACTTGGGATATATTAAATATTGCTGGCAATGCTGCCAAATAG t147.nt (SEQ ID NO:24) GCCGCAGCTAAAGCAAACCGCTTAAACAAAAAGCTAGACATTACTATCTATGAAAAAACAAAT ATTGTATCTTTTGGAACCTGTGGCCTGCCTTACTTTGTGGGGGGATTCTTTGACAACCCCAATAC AATGATCTCAAGAACACAAGAAGAATTCGAAAAAACTGGAATCTCTGTTAAAACTAACCACGA AGTTATCAAAGTAGATGCAAAAAACAATACAATTGTAATAAAAAATCAAAAAACAGGAACCAT TTTTAACAATACTTACGATCAACTTATGATAGCAACTGGTGCAAAACCTATTATTCCACCAATC AATAATATCAATCTAGAAAATTTTCATACTCTGAAAAATTTAGAAGACGGTCAAAAAATAAAAA AATTAATGGATAGAGAAGAGATTAAAAATATAGTGATAATTGGTGGTGGATACATTGGAATTG AAATGGTAGAAGCAGCAAAAAATAAAAGAAAAAATGTAAGATTAATTCAACTAGATAAGCACA TACTCATAGATTCCTTTGACGAAGAAATAGTCACAATAATGGAAGAAGAACTAACAAAAAAGG GGGTTAATCTTCATACAAATGAGTTTGTAAAAAGTTTAATAGGAGAAAAAAAGGCAGAAGGAG TAGTAACAAACAAAAATACTTATCAAGCTGACGCTGTTATACTTGCTACCGGAATAAAACCTGA CACTGAATTTTTAGAAAACCAGCTTAAAACTACTAAAAATGGAGCAATAATTGTAAATGAGTAT GGCGAAACTAGCATAAAAAATATTTTTTCTGCAGGAGATTGTGCAACTATTTATAATATAGTAA GTAAAAAAAATGAATACATACCCTTGGCAACAACAGCCAACAAACTTGGAAGAATAGTTGGTG AAAATTTAGCTGGGAATCATACAGCATTTAAAGGCACATTGGGCTCAGCTTCAATTAAAATACT ATCTTTAGAAGCTGCAAGAACAGGACTTACAGAAAAAGATGCAAAAAAGCTCCAAATAAAATA TAAAACGATTTTTGTAAAGGACAAAAATCATACAAATTATTATCCAGGCCAAGAAGATCTTTAT ATTAAATTAATTTATGAGGAAAATACCAAAATAATCCTTGGGGCACAAGCAATAGGAAAAAT GGAGCCGTAATAAGAATTCATGCTTTATCAATTGCAATCTATTCAAAACTTACAACAAAAGAGC TAGGGATGATGGATTTCTCATATTCCCCACCCTTCTCAAGAACTTGGGATATATTAAATATTGCT GGCAATGCTGCCAAATAG f152.aa (SEQ ID NO:25) MLKFEFSDRFLLFSYFVLIMFIGSLLLMLPISWEGDGKLAYIDALFTAVSAVSITGLTTVKMEGFSTFG FILIMLLIQLGGLGFISITTFYLLIPKKKMNLTDARIIKQYSLSNIEYNPIRILKSILFITFSIEMIGLILILIC FKLRGVNISFLEALFTTISAFCNAGFSMHSESIYAWRDVPEAIVVVSILIICGGLGFMVYRDVNNTIKN KKKLSLHAKIVFSLSFFLIIIGAILFFFTEMHKLKAGYSMSTLIFNSIFYSISTRTAGFNYLDNSLISGRT QIISLPFMFIGGAPGSTAGGIKITTFFLIVLAVVKNQNGNGYIIGSYKVSIDSIRFALLFFARAIFILSFSFF MLLFFEGGSGNWKVIDLGYEVFSAFGTVGLSVGVTQDLSFWGKVIIIFTMFAGRIGLFSMAVFVSRK SRFEEFTRPRQDILVG t152.aa (SEQ ID NO:26) WEGDGKLAYIDALFTAVSAVSITGLTTVKMEGFSTFGFILIMLLIQLGGLGFISITTFYLLIPKKKMNL TDARIIKQYSLSNIEYNPIRILKSILFITFSIEMIGLILILICFKLRGVNISFLEALFTTISAFCNAGFSMHSE SIYAWRDVPEAIVVVSILIICGGLGFMVYRDVNNTIKNKKKLSLHAKIVFSLSFFLIIIGAILFFFTEMH KLKAGYSMSTLIFNSIFYSISTRTAGFNYLDNSLISGRTQIISLPFMFIGGAPGSTAGGIKITTFFLIVLAV VKNQNGNGYIIGSYKVSIDSIRFALLFFARAIFILSFSFFMLLFFEGGSGNWKVIDLGYEVFSAFGTVG LSVGVTQDLSFWGKVIIIFTMFAGRIGLFSMAVFVSRKSRFEEFTRPRQDILVG f152.nt (SEQ ID NO:27) ATGTTGAAATTTGAATTTAGCGACAGGTTTTTACTTTTTAGTTATTTTGTTTTAATTATGTTTAT AGGCTCTCTTTTGTTGATGTTGCCTATTTCCTGGGAAGGTGATGGCAAATTAGCATACATTGAT GCTCTTTTTACTGCTGTTTCTGCTGTAAGTATTACGGGCCTTACAACGGTTAAAATGGAAGGCTT TTCTACTTTTGGATTTATTTTGATAATGTTGCTAATCCAGCTTGGGGGACTTGGATTTATAAGTA TTACTACTTTTTATTTGCTTATACCTAAAAAGAAAATGAATTTAACAGATGCAAGAATAATAAA GCAGTATTCCCTTTCAAATATAGAATATAATCCTATTAGAATTTTAAAAAGCATATTGTTTATAA CTTTTTCAATTGAAATGATAGGTTTAATATTAATACTTATTTGTTTTAAACTTAGGGGAGTGAAT ATTTCATTCTTAGAGGCTTTGTTTACGACAATTTCTGCTTTTTGCAATGCAGGTTTTTCCATGCA TTCTGAGAGTATTTATGCATGGCGAGATGTTCCTGAAGCTATAGTTGTGGTCTCTATTTTAATAA TTTGTGGTGGGCTTGGGTTTATGGTCTATAGAGATGTAAATAACACTATTAAAAACAAAAAAAA ACTATCGCTTCATGCCAAGATAGTTTTTTCTTTAAGCTTCTTTTTAATTATAATTGGTGCAATTTT ATTTTTTTTTACAGAGATGCATAAATTAAAAGCTGGTTATTCAATGAGCACTTTAATATTTAATT CAATTTTTTTATTCGATTAGTACCAGAACAGCTGGTTTTAATTATCTTGATAATTCTTTAATAAGC GGAAGAACTCAAATAATTTCTCTACCATTCATGTTTATTGGTGGTGCACCCGGATCAACTGCAG GAGGGATTAAGATTACAACATTTTTTTTAATTGTATTGGCTGTTGTTAAAAATCAAAACGGCAA TGGATATATTATTGGTTCTTACAAGGTTTCAATAGATAGTATAAGATTTGCACTTTTATTTTTTG CAAGAGCTATTTTTATTTTAAGTTTTTCTTTTTTCATGCTTCTTTTTTTTGAGGGAGGATCTGGCA ATTGGAAGGTTATTGATTTAGGTTATGAAGTATTTTCTGCTTTTGGAACGGTTGGTCTTTCAGTT GGAGTAACTCAGGATTTGTCATTTTGGGGGAAAGTCATTATAATTTTTACTATGTTTGCAGGAC GAATAGGGCTTTTTTCAATGGCTGTTTTTGTTTCAAGAAAGTCGCGTTTTGAAGAATTTACAAG GCCAAGGCAAGATATTTTGGTTGGTTGA t152.nt (SEQ ID NO:28) TGGGAAGGTGATGGCAAATTAGCATACATTGATGCTCTTTTTACTGCTGTTTCTGCTGTAAGTA TTACGGGCCTTACAACGGTTAAAATGGAAGGCTTTTCTACTTTTGGATTTATTTTGATAATGTTG CTAATCCAGCTTGGGGGACTTGGATTTATAAGTATTACTACTTTTTATTTGCTTATACCTAAAAA GAAAATGAATTTAACAGATGCAAGAATAATAAAGCAGTATTCCCTTTCAAATATAGAATATAAT CCTATTAGAATTTTAAAAAGCATATTGTTTATAACTTTTTCAATTGAAATGATAGGTTTAATATT AATACTTATTTGTTTTAAACTTAGGGGAGTGAATATTTCATTCTTAGAGGCTTTGTTTACGACAA TTTCTGCTTTTTGCAATGCAGGTTTTTCCATGCATTCTGAGAGTATTTATGCATGGCGAGATGTT CCTGAAGCTATAGTTGTGGTCTCTATTTTAATAATTTGTGGTGGGCTTGGGTTTATGGTCTATAG AGATGTAAATAACACTATTAAAAACAAAAAAAAACTATCGCTTCATGCCAAGATAGTTTTTTCT TTAAGCTTCTTTAATTATAATTGGTGCAATTTTATTTTTTTTTACAGAGATGCATAAATTAAA AGCTGGTTATTCAATGAGCACTTTAATATTTAATTCAATTTTTTATTCGATTAGTACCAGAACAG CTGGTTTTAATTATCTTGATAATTCTTTAATAAGCGGAAGAACTCAAATAATTTCTCTACCATTC ATGTTTATTGGTGGTGCACCCGGATCAACTGCAGGAGGGATTAAGATTACAACATTTTTTTTAA TTGTATTGGCTGTTGTTAAAAATCAAAACGGCAATGGATATATTATTGGTTCTTACAAGGTTTC AATAGATAGTATAAGATTTGCACTTTTATTTTTTGCAAGAGCTATTTTTATTTTAAGTTTTTCTTT TTTCATGCTTCTTTTTTTTGAGGGAGGATCTGGCAATTGGAAGGTTATTGATTTAGGTTATGAAG TATTTTTCTGCTTTTGGAACGGTTGGTCTTTCAGTTGGAGTAACTCAGGATTTGTCATTTTGGGGG AAAGTCATTATAATTTTTACTATGTTTGCAGGACGAATAGGGCTTTTTTCAATGGCTGTTTTTGT TTCAAGAAAGTCGCGTTTTGAAGAATTTACAAGGCCAAGGCAAGATATTTTGGTTGGTTGA f154.aa (SEQ ID NO:29) MKINKTFILLFLFTKFSFVQAQANQILTEISPLSISLKNGKGSVYLKVSKSSDYILTLDKSSNSDFVFKI YDISNKKYITDKVKRRDFKIRLDKNSLYAIIYVGTKNENIKFSLTDLDFSILSSDSLKAKTSKIEKEDLF FTLKDLPVLNLTAKLKKYVLRIYKSNIYIAYQLENSDDIKVAEFIEDVGWFNLDSSVNRNITNIVNFD FSINSKGNLYIAFVTKSGADFASELIVKKFNSRKWIDISPGHIENFGSLLNISIDLKDRLYLAYLREIRG EYKINLISNMGYGSIWTDVIHAYLSKGDSNVNSSNIGLISEPFLGIFYNYKSNNEIKSEFIVNNENAWV NANIPSVYMANFIKGFFDSNFNQIIMSFVSENRPIVNICPLKSSRWINISPNVEMEGLSADIGLYKNNL FLAFEDNNNVRLIYFKNKNWYFLNKLENFKSNVKSPQIGIYGNQGLVISTLSSNSNELFFTLICQ t154.aa (SEQ ID NO:30) NQILTEISPLSILSKNGKGSVYLKVSKSSDYILTLDKSSNSDFVFKIYDISNKKYITDKVKRRDFKIRLD KNSLYAIIYVGTKNENIKFSLTDLDFSILSSDSLKAKTSKIEKEDLFFTLKDLPVLNLTAKLKKYVLRI YKSNIYIAYQLENSDDIKVAEFIEDVGWFNLDSSVNRNITNIVNFDFSINSKGNLYIAFVTKSGADFAS ELIVKKFNSRKWIDISPGHIENFGSLLNISIDLKDRLYLAYLREIRGEYKINLISNMGYGSIWTDVIHAY LSKGDSNVNSSNIGLISEPFLGIFYNYKSNNEIKSEFIVNNENAWVNANIPSVYMANFIKGFFDSNFNQ IIMSFVSENRPIVNICPLKSSRWINISPNVEMEGLSADIGLYKNNLFLAFEDNNNVRLIYFKNKNWYFL NKLENFKSNVKSPQIGIYGNQGLVISTLSSNSNELFFTLICQ f154.nt (SEQ ID NO:31) ATGAAAATAAATAAGACATTCATTTTGCTATTTTTATTTACAAAATTTTTCTTTTGTTCAAGCTCA AGCAAATCAAATATTAACAGAAATTAGTCTTTAAGTATTTTAAGCAAAAATGGGAAAGGAAG TGTTTACTTAAAAGTTAGCAAATCTTCCGATTATATTTTAACCCTAGATAAGAGTTCAAATTCCG ATTTTGTTTTTAAAATTTATGACATTTCTAATAAAAAATATATAACCGATAAAGTAAAAAGAAG AGATTTTAAAATAAGATTAGATAAAAATTCTCTTTATGCAATAATATATGTTGGTACTAAAAAT GAAAACATAAAGTTTTCGCTTACAGATTTAGATTTTTCAATTTTAAGTAGCGATTCCCTGAAAG CTAAAACATCTAAGATTGAAAAAGAAGATTTATTTTTTACTTTAAAAGATTTGCCTGTTTTAAAT TTAACTGCCAAGCTTAAAAAATATGTATTAAGGATTTATAAAAGCAATATTTATATTGCTTATC AGCTAGAAAATAGCGATGATATTAAAGTTGCTGAATTTATTGAGGATGTTGGTTGGTTTAATCT TGATTCATCTGTTAATAGAAATATTACTAATATAGTTAATTTTGATTTTTCAATTAATTCTAAAG GAAATTTATATATTGCTTTTGTTACGAAATCAGGGGCTGATTTTGCCAGCGAGCTTATAGTTAA AAAATTTAATAGTAGAAAATGGATTGATATTAGTCCTGGTCACATAGAAAATTTTGGATCTTTA TTAAATATTAGCATTGATTTAAAAGATAGGTTGTATTTAGCATATTTAAGGGAAATTAGGGGTG AATATAAAATTAATTTAATCTCGAATATGGGTTACGGAAGTATTTGGACCGATGTAATACATGC TTATTTAAGTAAAGGTGATTCTAATGTTAATTCATCAAACATTGGTTTAATATCTGAACCTTTTT TGGGCATTTTTTATAATTATAAGTCAAATAATGAGATTAAATCTGAATTTATTGTAAACAATGA AAATGCTTGGGTAAATGCAAATATTCCTTCTGTTTATATGGCCAATTTTATTAAAGGCTTTTTG ATTCTAATTTTAATCAAATAATTATGAGTTTTGTTTCTGAAAATAGACCTATTGTAAACATTTGT CCTTTGAAAAGTAGTAGATGGATTAATATAAGTCCTAATGTTGAAATGGAAGGTTTAAGTGCTG ACATTGGGCTTTATAAAAATAATTTGTTTTTAGCTTTTGAGGACAATAATAATGTGAGATTAAT TTATTTTAAGAATAAAAATTGGTATTTTTTAAATAAGCTTGAGAATTTTAAGAGTAATGTTAAA AGCCCTCAGATTGGAATTTATGGCAATCAAGGGCTTGTAATCTCTACTTTAAGCTCTAATTCCA ATGAATTATTTTTTACTTTGATTTGCCAATGA t154.nt (SEQ ID NO:32) AATCAAATATTAACAGAAATTAGTCCTTTAAGTATTTTAAGCAAAAATGGGAAAGGAAGTGTTT ACTTAAAAGTTAGCAAATCTTCCGATTATATTTTAACCCTAGATAAGAGTTCAAATTCCGATTTT GTTTTTAAAATTTATGACATTTCTAATAAAAAATATATAACCGATAAAGTAAAAAGAAGAGATT TTAAAATAAGATTAGATAAAAATTCTCTTTATGCAATAATATATGTTGGTACTAAAAATGAAAA CATAAAGTTTTCGCTTACAGATTTAGATTTTTCAATTTTAAGTAGCGATTCCCTGAAAGCTAAAA CATCTAAGATTGAAAAAGAAGATTTATTTTTTACTTTAAAAGATTTGCCTGTTTTAAATTTAACT GCCAAGCTTAAAAAATATGTATTAAGGATTTATAAAAGCAATATTTATATTGCTTATCAGCTAG AAAATAGCGATGATATTAAAGTTGCTGAATTTATTGAGGATGTTGGTTGGTTTAATCTTGATTC ATCTGTTAATAGAAATATTACTAATATAGTTAATTTTGATTTTTCAATTAATTCTAAAGGAAATT TATATATTGCTTTTGTTACGAAATCAGGGGCTGATTTTGCCAGCGAGCTTATAGTTAAAAAATT TAATAGTAGAAAATGGATTGATATTAGTCCTGGTCACATAGAAAATTTTGGATCTTTATTAAAT ATTAGCATTGATTTAAAAGATAGGTTGTATTTAGCATATTTAAGGGAAATTAGGGGTGAATATA AAATTAATTTAATCTCGAATATGGGTTACGGAAGTATTTGGACCGATGTAATACATGCTTATTT AAGTAAAGGTGATTCTAATGTTAATTCATCAAACATTGGTTTAATATCTGAACCTTTTTTGGGCA TTTTTTATAATTATAAGTCAAATAATGAGATTAAATCTGAATTTATTGTAAACAATGAAAATGC TTGGGTAAATGCAAATATTCCTTCTGTTTATATGGCCAATTTTATTAAAGGCTTTTTTGATTCTA ATTTTAATCAAATAATTATGAGTTTTGTTTCTGAAAATAGACCTATTGTAAACATTTGTCCTTTG AAAAGTAGTAGATGGATTAATATAAGTCCTAATGTTGAAATGGAAGGTTTAAGTGCTGACATTG GGCTTTATAAAAATAATTTGTTTTTAGCTTTTGAGGACAATAATAATGTGAGATTAATTTATTTT AAGAATAAAAATTGGTATTTTTAAATAAGCTTGAGAATTTTAAGAGTAATGTTAAAAGCCCTC AGATTGGAATTTATGGCAATCAAGGGCTTGTAATCTCTACTTTAAGCTCTAATTCCAATGAATT ATTTTTTACTTTGATTTGCCAATGA f157.aa (SEQ ID NO:33) MKIFLKVIGRGILGRLMVFRKNYDYLALISLLIVSFVGILLIYSSDYNISGSLTKNEYIKQTFW VIIGFFLIFIVGKYDLKFVYSMVYPLYFLLILALIFTAFFGMTVNGARSWIGIWKLGGQPSEFGKVVIIL TLSKFYTEKKGYNEFFTFITAFLLIFPSVILILLQPDFGTAIVYLTIFIFISFFAGIDLHYVLAFALIGFFSF VFAILPVWYEYKVNMGNVFYLIFSNPFYFRVIMGVLLLILLISVLGFFISKYGLSIKIIYFYVFFASSILL VSIVFSKVLSKLMKTYQIKRFLVFLDPAIDAKGAGWNLNQVKIAIGSGGLLGKGFLKGPYTHANYVP SQSTDFIFSILAEEFGFLGVSTILILFFFLFFKFLIIMNKSQDRYMALVISGILGLLFFHTSFNVGMSLGV LPITGIPFPFLSYGGSSTITFFLAMSFYFNIESIVAMD t157.aa (SEQ ID NO:34) RKNYDYLALISLLIVSFVGILLIYSSDYNISGSLTKNEYIKQTFWVIIGFFLIFIVGKYDLKFVYSMVYP LYFLLILALIFTAFFGMTVNGARSWIGIWKLGGQPSEFGKVVIILTLSKFYTEKKGYNEFFTFITAFLLI FPSVILILLQPDFGTAIVYLTIFIFISFFAGIDLHYVLAFALIGFFSFVFAILPVWYEYKVNMGNVFYLIFS NPFYFRVIMGVLLLILLISVLGFFISKYGLSIKIIYFYVFFASSILLVSIVFSKVLSKLMKTYQIKRFLVFL DPAIDAKGAGWNLNQVKIAIGSGGLLGKGFLKGPYTHANYVPSQSTDFIFSILAEEFGFLGVSTILILF FFLFFKFLIIMNKSQDRYMALVISGILGLLFFHTSFNVGMSLGVLPITGIPFPFLSYGGSSTITFFLAMSF YFNIESIVAMD f157.nt (SEQ ID NO:35) ATGAAGATATTCTTAAAGGTTATAGGCCGTGGTATATTAGGTAGATTAATGGTTTTTAGAAAAA ATTATGATTATTTGGCTTTGATAAGCTTACTTATAGTTTCTTTTGTTGGTATATTGTTGATTTATT CTAGCGATTATAATATTAGTGGATCTTTAACCAAGAATGAATATATAAAACAAACCTTTTGGGT AATTATTGGATTTTTTCTAATTTTTATAGTGGGCAAATATGATTTAAAATTTGTTTATAGCATGG TATATCCTTTATATTTTTTATTAATATTGGCTTTAATTTTTACTGCATTTTTTGGAATGACAGTAA ATGGAGCAAGATCTTGGATTGGCATATGGAAACTTGGAGGACAGCCTTCTGAATTTGGTAAAGT TGTTATTATTTTAACCCTTTCAAAATTTTACACTGAAAAAAAGGGTTATAATGAATTTTTTACCT TTATTACTGCATTTTTATTAATTTTTCCATCGGTAATTCTTATATTATTGCAACCTGATTTTGGTA CAGCAATAGTATATTTAACCATTTTTATATTTATTTCTTTTTTTGCAGGAATAGATTTGCACTAT GTTTTAGCATTTGCGTTGATAGGGTTTTTTTCTTTTGTTTTTGCAATTTTACCGGTTTGGTATGA ATATAAGGTGAATATGGGTAATGTATTTTATCTTATTTTCTCAAATCCTTTTTATTTTAGAGTAA TAATGGGAGTGCTGCTTTTAATTCTTTTGATTTCTGTTTTAGGATTTTTCATTTCTAAATATGGTT TGAGTATTAAAATAATTTATTTTTATGTATTTTTTGCAAGTTCTATTTTATTAGTTTCAATAGTGT TTTCAAAGGTTCTTTCAAAGTTAATGAAGACTTATCAGATTAAACGGTTTTTGGTATTCTTAGAT CCGGCTATTGATGCTAAGGGTGCTGGTTGGAATTTAAATCAGGTTAAAATAGCAATTGGTTCTG GCGGTCTTTTGGGCAAAGGATTTTAAAGGGACCTTATACCCACGCTAATTATGTGCCATCTCA AAGCACAGATTTTATTTTTTCTATTCTTGCCGAAGAGTTTGGGTTTTTGGGTGTTAGCACTATTT TAATATTATTTTTTTTCCTTTTTTTTAAATTTTTGATAATAATGAATAAAAGTCAAGATAGATAT ATGGCCTTAGTAATATCTGGAATTTTGGGACTTTTATTTTTTCATACTTCTTTTAATGTTGGAAT GTCTTTAGGAGTTCTTCCTATTACCGGGATTCCCTTTCCTTTTCTCTCTTATGGAGGTTCTTCTAC TATTACATTTTTTTTAGCAATGTCTTTTTATTTTAATATTGAATCAATAGTTGCTATGGATTGA t157.nt (SEQ ID NO:36) AGAAAAAATTATGATTATTTGGCTTTGATAAGCTTACTTATAGTTTCTTTTGTTGGTATATTGTT GATTTATTCTAGCGATTATAATATTAGTGGATCTTTAACCAAGAATGAATATATAAAACAAACC TTTTGGGTAATTATTGGATTTTTTCTAATTTTTATAGTGGGCAAATATGATTTAAAATTTGTTTA TAGCATGGTATATCCTTTATATTTTTATTAATATTGGCTTTAATTTTTACTGCATTTTTTGGAAT GACAGTAAATGGAGCAAGATCTTGGATTGGCATATGGAAACTTGGAGGACAGCCTTCTGAATTT GGTAAAGTTGTTATTATTTTAACCCTTTCAAAATTTTACACTGAAAAAAAGGGTTATAATGAAT TTTTTACCTTTATTACTGCATTTTTATTAATTTTTCCATCGGTAATTCTTATATTATTGCAACCTG ATTTTGGTACAGCAATAGTATATTTAACCATTTTTATATTTATTTCTTTTTTTGCAGGAATAGAT TTGCACTATGTTTTAGCATTTGCGTTGATAGGGTTTTTTTCTTTTGTTTTTGCAATTTTACCGGTT TGGTATGAATATAAGGTGAATATGGGTAATGTATTTTATCTTATTTTCTCAAATCCTTTTTATTT TAGAGTAATAATGGGAGTGCTGCTTTTAATTCTTTTGATTTCTGTTTTAGGATTTTTCATTTCTA AATATGGTTTGAGTATTAAAATAATTTATTTTTATGTATTTTTTGCAAGTTCTATTTTATTAGTTT CAATAGTGTTTTCAAAGGTTCTTTCAAAGTTAATGAAGACTTATCAGATTAAACGGTTTTTGGT ATTCTTAGATCCGGCTATTGATGCTAAGGGTGCTGGTTGGAATTTAAATCAGGTTAAAATAGCA ATTGGTTCTGGCGGTCTTTTGGGCAAAGGATTTTTAAAGGGACCTTATACCCACGCTAATTATG TGCCATCTCAAAGCACAGATTTTATTTTTTCTATTCTTGCCGAAGAGTTTGGGTTTTTGGGTGTT AGCACTATTTTAATATTATTTTTTTTCCTTTTTTTTAAATTTTTGATAATAATGAATAAAAGTCA AGATAGATATATGGCCTTAGTAATATCTGGAATTTTGGGACTTTTATTTTTTCATACTTCTTTTA ATGTTGGAATGTCTTTAGGAGTTCTTCCTATTACCGGGATTCCCTTTCCTTTTCTCTCTTATGGA GGTTCTTCTACTATTACATTTTTTTTAGCAATGTCTTTTTATTTTAATATTGAATCAATAGTTGCT ATGGATTGA f17.aa (SEQ ID NO:37) MIVFLFFSIYLIILFKRSSNSPLYFVPDTKFETLSIRIVLSCSLLLIFFCTMLDARPSTIAVFPTPGSPISIAL FLFLLKSIFVRVLISASLPTKGSNFLAFASAVKFLTYFPISKCSFSSRISSSNSL t17.aa (SEQ ID NO:38) PLYFVPDTKFETLSIRIVLSCSLLLIFFCTMLDARPSTIAVFPTPGSPISIALFLFLLKSIFVRVLISASLPT KGSNFLAFASAVKFLTYFPISKCSFSSRISSSNSL f17.nt (SEQ ID NO:39) ATGATTGTGTTTTTGTTTTTTTCAATATACTTAATTATATTATTTAAACGATCTTCAAACTCGCCT CTATATTTTGTTCCCGATACCAAGTTTGAAACCTTAAGCATTAGAATTGTTTTGTCTTGTAGTTT GCTACTTATTTTTTTTTGCACTATGCTTGATGCAAGGCCTTCAACTATTGCTGTTTTTCCCACACC AGGTTCGCCTATTAGCATTGCACTATTTTTATTTCTTCTCAAGAGTATATTTGTAAGAGTTTTAA TCTCTGCTTCTCTTCCAACCAAGGGGTCTAATTTTTTGGCTTTTGCAAGTGCTGTTAAATTTTTG ACATACTTTCCAATTTCAAAGTGCTCATTTTCAAGTCGTATTTCTTCATCAAATTCTTTGTAG t17.nt (SEQ ID NO:40) CCTCTATATTTTGTTCCCGATACCAAGTTTGAAACCTTAAGCATTAGAATTGTTTTGTCTTGTAG TTTGCTACTTATTTTTTTTTGCACTATGCTTGATGCAAGGCCTTCAACTATTGCTGTTTTTCCCAC ACCAGGTTCGCCTATTAGCATTGCACTATTTTTATTTCTTCTCAAGAGTATATTTGTAAGAGTTT TAATCTCTGCTTCTCTTCCAACCAAGGGGTCTAATTTTTTGGCTTTTGCAAGTGCTGTTAAATTT TTGACATACTTTCCAATTTCAAAGTGCTCATTTTCAAGTCGTATTTCTTCATCAAATTCTTTGTA G f170.aa (SEQ ID NO:41) MKAFKVKNLRRFSNFIRILVIVLFLNSLLSLFVFLAGSYNIFVYNFQKFYLDLAIILSSVSFGLESTRLIF FYFLKNKKIKYYLILIFSFIIFFIALVFKIFLSGNK t170.aa (SEQ ID NO:42) YNIFVYNFQKFYLDLAIILSSVSFGLESTRLIFFYFLKNKKIKYYLILIFSFIIFFIALVFKIFLSGNK f170.nt (SEQ ID NO:43) ATGAAAGCTTTTAAAGTAAAAAATCTAAGACGTTTTTCAAATTTTATTAGAATTTTGGTTATTGT ATTGTTTTTAAATTCTTTGTTAAGTTTGTTCGTGTTTTTGGCTGGTTCTTACAATATTTTTGTTTA CAATTTTCAGAAATTTTATCTTGATCTTGCTATTATTTTAAGCTCTGTTTCTTTTGGACTTGAATC TACTAGACTGATATTTTTTTATTTTTTGAAAAATAAAAAAATTAAGTATTATTTAATTTTAATTT TTAGTTTTATAATTTTTTTTATTGCTCTTGTTTTTAAAATTTTTCTTTCTGGTAATAA ATAG t170.nt (SEQ ID NO:44) TACAATATTTTTGTTTACAATTTTCAGAAATTTTATCTTGATCTTGCTATTATTTTAAGCTCTGTT TCTTTTGGACTTGAATCTACTAGACTGATATTTTTTTATTTTTTGAAAAATAAAAAAATTAAGTA TTATTTAATTTTAATTTTTAGTTTTATAATTTTTTTTATTGCTCTTGTTTTTAAAATTTTTCTTTCT GGTAATAAATAG f186.aa (SEQ ID NO:45) MKKLIIIFTLFLSQACNLSTMHKIDTKEDMKILYSEIAELRKKLNLNHLEIDDTLEKVAKEYAIKLGEN RTITHTLFGTTPMQRIHKYDQSFNLTREILASGIELNRVVNAWLNSPSHKEALINTDTDKIGGYRLKT TDNIDIFVVLFGKRKYKN t186.aa (SEQ ID NO:46) TMHKIDTKEDMKILYSEIAELRKKLNLNHLEIDDTLEKVAKEYAIKLGENRTITHTLFGTTPMQRIHK YDQSFNLTREILASGIELNRVVNAWLNSPSHKEALINTDTDKIGGYRLKTTDNIDIFVVLFGKRKYKN f186.nt (SEQ ID NO:47) ATGAAAAAATTGATTATAATTTTTACACTGTTTTTATCTCAAGCATGCAATTTAAGTACAATGCA TAAAATAGATACAAAAGAAGATATGAAAATTCTATATTCAGAAATTGCTGAATTGAGAAAAAA ATTAAATCTAAACCATCTAGAAATAGATGATACCCTTGAAAAAGTTGCAAAAGAATATGCCATT AAACTGGGAGAAAATAGAACAATAACTCACACCCTTTTTGGCACAACCCCAATGCAAAGAATA CATAAATACGATCAATCCTTTAATTTAACAAGAGAAATACTGGCATCAGGAATTGAACTTAACA GAGTAGTTAATGCATGGCTTAATAGTCCAAGCCACAAAGAAGCTCTTATTAATACAGATACCGA TAAAATAGGTGGCTATAGATTAAAAACGACTGACAATATAGATATATTTGTAGTTCTTTTTGGA AAAAGAAAATATAAGAATTGA t186.nt (SEQ ID NO:48) ACAATGCATAAAATAGATACAAAAGAAGATATGAAAATTCTATATTCAGAAATTGCTGAATTG AGAAAAAAATTAAATCTAAACCATCTAGAAATAGATGATACCCTTGAAAAAGTTGCAAAAGAA TATGCCATTAAACTGGGAGAAAATAGAACAATAACTCACACCCTTTTTGGCACAACCCCAATGC AAAGAATACATAAATACGATCAATCCTTTAATTTAACAAGAGAAATACTGGCATCAGGAATTGA ACTTAACAGAGTAGTTAATGCATGGCTTAATAGTCCAAGCCACAAAGAAGCTCTTATTAATACA GATACCGATAAAATAGGTGGCTATAGATTAAAAACGACTGACAATATAGATATATTTGTAGTTC TTTTTGGAAAAAGAAAATATAAGAATTGA f196.aa (SEQ ID NO:49) MKLKARMLLLVLILIAFFISILFFAFGMLINSKLVDQQFNLMINLIESIKSSFNLYISSMEEKVR VSSMYFNSAEKFNEASKIKSKRLSFISDQSEILIQTGSNMMVTDKEGKIVFTTAVKDNSDFGKSIGDR EYFTKLKESNSIVYNSFVMLADPGSIEESLLKDISKIKNKKGQIPYILIGMPLRDFETDNIFGYFMFLYS MDYIYRSFRGINFGILSSGRALAYDTTGRLLVHHVVLPGDILTDISASYSNIIKKTSEDLLQKNKEIST VYYYDPKSNKKYVGISQKVLLNLSNNKFILLMRTSEDDFYYMSRATTIILAISFVFTLLMLAIATLYL VKKLSSSLNKILEYSERLASGNFTADINFGKWDTVELYSLYEGLEQLRTNFSSVAKGVIENLDYLYE NAIQIANASQNLSSGAVEQASTLEQMTANIEQISQGVSENTENAATTEKIAVNTNERTKEGHKSVVK AIEAMTVITEKIGIIDEITRQTNLLALNASIEAARVGEKGKGFEVVAAEVRKLADQSKESAREIIDIAN RSLTVASRAGENFEQIVPGMEQTARLVKNISNESYKQSVQIEQFKNAIEQVSQLVQTTASSSEELSAM SEKMLESVKDLKESVDYFKIEK t196.aa (SEQ ID NO:50) MLINSKLVDQQFNLMINLIESIKSSFNLYISSMEEKVRVSSMYFNSAEKFNEASKIKSKRLSFISDQSEI LIQTGSNMMVTDKEGKIVFTTAVKDNSDFGKSIGDREYFTKLKESNSIVYNSFVMLADPGSIEESLLK DISKIKKKGQIPYILIGMPLRDFETDNIFGYFMFLYSMDYIYRSFRGINFGILSSGRALAYDTTGRLL VHHVVLPGDILTDISASYSNIIKKTSEDLLQKNKEISTVYYYDPKSNKKYVGISQKVLLNLSNNKFILL MRTSEDDFYYMSRATTIILAISFVFTLLMLAIATLYLVKKLSSSLNKILEYSERLASGNFTADINFGKW DTVELYSLYEGLEQLRTNFSSVAKGVIENLDYLYENAIQIANASQNLSSGAVEQASTLEQMTANIEQI SQGVSENTENAATTEKIAVNTNERTKEGHKSVVKAIEAMTVITEKIGIIDEITRQTNLLALNASIEAAR VGEKGKGFEVVAAEVRKLADQSKESAREIIDIANRSLTVASRAGENFEQIVPGMEQTARLVKNISNE SYKQSVQIEQFKNAIEQVSQLVQTTASSSEELSAMSEKMLESVKDLKESVDYFKIEK f196.nt (SEQ ID NO:51) ATGAAGCTTAAAGCTAGGATGTTGCTACTTGTTCTTATTCTGATAGCATTCTTTATATCA ATTTTGTTTTTTGCTTTTGGAATGCTTATTAATAGTAAATTGGTGGATCAACAGTTTAATCTTAT GATAAATCTTATTGAAAGCATTAAAAGTTCTTTTAATCTTTACATCTCTTCAATGGAAGAGAAA GTTAGGGTTAGTTCCATGTATTTCAACTCTGCTGAAAAATTTAATGAGGCTAGTAAAATTAAAT CCAAAAGGTTGAGCTTTATTTCAGATCAATCTGAAATTCTTATTCAAACCGGTAGTAATATGAT GGTTACAGACAAAGAAGGTAAAATAGTGTTTACTACGGCGGTTAAGGATAATAGTGATTTTGG CAAATCTATTGGGGATAGAGAATATTTTACAAAACTTAAGGAGTCTAATAGTATTGTTTACAAT TCCTTTGTCATGTTGGCAGATCCCGGGTCTATTGAGGAGTCTTTACTTAAAGATATTTCCAAGAT AAAAAATAAAAAAGGTCAGATTCCTTACATATTAATAGGTATGCCATTAAGAGATTTTGAAACA GATAACATTTTTGGTTATTTTATGTTTCTTTATTCAATGGATTATATATATAGGTCTTTTAGAGG GATTAATTTTGGAATACTCTCTAGCGGTCGTGCGCTAGCTTATGATACTACGGGTAGATTGTTG GTTCATCATGTAGTATTGCCAGGTGATATTTTGACTGATATTAGTGCTTCTTATTCCAATATTAT TAAGAAAACATCTGAAGATTTGTTGCAAAAGAATAAAGAAATTTCAACTGTTTATTATTATGAT CCTAAAAGCAATAAGAAATATGTGGGAATTAGTCAAAAGGTGTTATTAAACTTGTCTAATAATA AATTTATTCTTTTAATGAGAACTTCAGAGGACGATTTTTATTACATGTCACGAGCTACAACTATA ATCTTAGCAATTAGTTTTGTATTTACATTACTTATGCTTGCTATTGCAACTCTTTATCTTGTGAA AAAGTTAAGCTCTTCTTTGAATAAGATACTGGAATATTCTGAGAGAGTTGCTTCTGGTAATTTT ACTGCTGATATTAATTTTGGCAAATGGGATACTGTAGAGCTTTACAGTTTGTACGAAGGGCTTG AGCAGTTGAGAACCAATTTTTCTTCAGTTGCAAAAGGAGTTATTGAAAATCTAGATTATCTTTA TGAAAATGCAATTCAAATAGCAAATGCAAGCCAGAATTTAAGTTCTGGCGCTGTTGAGCAGGCT TCTACTTTAGAGCAAATGACAGCAAATATTGAGCAAATTTCACAAGGTGTTTCTGAGAATACTG AAAATGCAGCTACTACTGAAAAAATTGCTGTTAATACTAATGAAAGGACTAAAGAGGGGCATA AATCTGTTGTTAAGGCTATTGAGGCAATGACTGTAATTACTGAAAAAATTGGAATTATTGATGA GATAACAAGGCAAACCAATTTGCTTGCTTTAAATGCCTCGATTGAAGCTGCACGAGTGGGAGAA AAGGGCAAGGGATTTGAAGTGGTAGCTGCTGAGGTTAGAAAGCTTGCAGATCAAAGCAAAGAA TCAGCAAGAGAGATTATTGATATTGCAAACAGAAGTTTAACTGTTGCAAGTCGTGCTGGGGAA AATTTTGAACAAATAGTTCCTGGTATGGAACAAACAGCCAGACTTGTAAAAAATATTTCTAATG AAAGTTATAAGCAAAGTGTTCAAATAGAGCAATTTAAAAATGCAATAGAGCAGGTTAGTCAGT TAGTCCAAACTACAGCCTCAAGCAGTGAAGAGCTTTCTGCAATGTCTGAAAAGATGTTAGAGAG TGTAAAAGATTTAAAAGAATCTGTTGATTATTTTAAGATCGAAAAGTAA t196.nt (SEQ ID NO:52) ATGCTTATTAATAGTAAATTGGTGGATCAACAGTTTAATCTTATGATAAATCTTATTGAAAGCA TTAAAAGTTCTTTTAATCTTTACATCTCTTCAATGGAAGAGAAAGTTAGGGTTAGTTCCATGTAT TTCAACTCTGCTGAAAAATTTAATGAGGCTAGTAAAATTAAATCCAAAAGGTTGAGCTTTATTT CAGATCAATCTGAAATTCTTATTCAAACCGGTAGTAATATGATGGTTACAGACAAAGAAGGTAA AATAGTGTTTACTACGGCGGTTAAGGATAATAGTGATTTTGGCAAATCTATTGGGGATAGAGAA TATTTTACAAAACTTAAGGAGTCTAATAGTATTGTTTACAATTCCTTTGTCATGTTGGCAGATCC CGGGTCTATTGAGGAGTCTTTACTTAAAGATATTTCCAAGATAAAAAATAAAAAAGGTCAGATT CCTTACATATTAATAGGTATGCCATTAAGAGATTTTGAAACAGATAACATTTTTGGTTATTTTAT GTTTCTTTATTCAATGGATTATATATATAGGTCTTTTAGAGGGATTAATTTTGGAATACTCTCTA GCGGTCGTGCGCTAGCTTATGATACTACGGGTAGATTGTTGGTTCATCATGTAGTATTGCCAGG TGATATTTTGACTGATATTAGTGCTTCTTATTCCAATATTATTAAGAAAACATCTGAAGATTTGT TGCAAAAGAATAAAGAAATTTCAACTGTTTATTATTATGATCCTAAAAGCAATAAGAAATATGT GGGAATTAGTCAAAAGGTGTTATTAAACTTGTCTAATAATAAATTTATTCTTTTAATGAGAACT TCAGAGGACGATTTTTATTACATGTCACGAGCTACAACTATAATCTTAGCAATTAGTTTTGTATT TACATTACTTATGCTTGCTATTGCAACTCTTTATCTTGTGAAAAAGTTAAGCTCTTCTTTGAATA AGATACTGGAATATTCTGAGAGACTTGCTTCTGGTAATTTTACTGCTGATATTAATTTTGGCAA ATGGGATACTGTAGAGCTTTACAGTTTGTACGAAGGGCTTGAGCAGTTGAGAACCAATTTTTCT TCAGTTGCAAAAGGAGTTATTGAAAATCTAGATTATCTTTATGAAAATGCAATTCAAATAGCAA ATGCAAGCCAGAATTTAAGTTCTGGCGCTGTTGAGCAGGCTTCTACTTTAGAGCAAATGACAGC AAATATTGAGCAAATTTCACAAGGTGTTTCTGAGAATACTGAAAATGCAGCTACTACTGAAAAA ATTGCTGTTAATACTAATGAAAGGACTAAAGAGGGGCATAAATCTGTTGTTAAGGCTATTGAGG CAATGACTGTAATTACTGAAAAAATTGGAATTATTGATGAGATAACAAGGCAAACCAATTTGCT TGCTTTAAATGCCTCGATTGAAGCTGCACGAGTGGGAGAAAAGGGCAAGGGATTTGAAGTGGT AGCTGCTGAGGTTAGAAAGCTTGCAGATCAAAGCAAAGAATCAGCAAGAGAGATTATTGATAT TGCAAACAGAAGTTTAACTGTTGCAAGTCGTGCTGGGGAAAATTTTGAACAAATAGTTCCTGGT ATGGAACAAACAGCCAGACTTGTAAAAAATATTTCTAATGAAAGTTATAAGCAAAGTGTTCAA ATAGAGCAATTTAAAAATGCAATAGAGCAGGTTAGTCAGTTAGTCCAAACTACAGCCTCAAGC AGTGAAGAGCTTTCTGCAATGTCTGAAAAGATGTTAGAGAGTGTAAAAGATTTAAAAGAATCT GTTGATTATTTTAAGATCGAAAAGTAA f899.aa (SEQ ID NO:53) MRFIIAFLMILNQGFSNLFSLPPEDIIFESSYEVAIKKAQKLNKNVLILVGRDIKENLIKDFLNS FTNGEIIHKVSRKSVFLVIDKDNEIFNKINLQKSPTIFFVDSKNEQIKAAYVGAVLSSVQFDKDFLNYV MGAIKSTSVLKKQKDYEINTADERTFFYKTLKGDWRLKFNGKDRKLVLFDTDLKEFLVFKDINENK LYAIPKSRIGNIYFSLLGNEEWKLFGKIK t899.aa (SEQ ID NO:54) LPPEDIIFESSYEVAIKKAQKLNKNVLILVGRDIKENLIKDFLNSFTNGEIIHKVSRKSVFLVIDKDNEIF NKINLQKSPTIFFVDSKNEQIKAAYVGAVLSSVQFDKDFLNYVMGAIKSTSVLKKQKDYEINTADER TFFYKTLKGDWRLKFNGKDRKLVLFDTDLKEFLVFKDINENKLYAIPKSRIGNIYFSLLGNEEWKLF GKIK f899.nt (SEQ ID NO:55) ATGAGATTTATAATTGCATTTTTAATGATTTTAAATCAAGGATTTTCAAATTTGTTTTCT TTGCCTCCGGAAGATATTATTTTTGAGAGTTCTTATGAGGTTGCAATTAAAAAAGCTCAAAAAT TGAATAAAAATGTTTTAATTTTGGTTGGTAGAGATATTAAAGAAAATTTAATAAAAGATTTTTT AAACTCTTTTACAATGGTGAAATTATTCACAAAGTATCTAGAAAAAGTGTTTTTTTAGTTATTG ATAAGGATAATGAAATTTTTAATAAAATTAATCTACAAAAAAGTCCGACTATTTTTTTTGTTGA TTCTAAGAATGAGCAAATAAAGGCAGCTTATGTGGGAGCTGTTTTGAGCAGTGTTCAATTTGAT AAGGATTTTTTAAACTATGTTATGGGAGCTATAAAATCAACAAGTGTTTTAAAAGCAAAAAG ATTATGAAATTAATACTGCTGATGAGAGAACCTTTTTTTACAAAACATTAAAAGGTGATTGGCG ATTAAAGTTTAATGGTAAAGACAGAAAGCTTGTTCTTTTTGATACAGATCTTAAAGAATTTTTA GTTTTTAAAGATATTAATGAAAACAAGCTTTATGCTATTCCTAAGTCTAGGATTGGTAATATTTA TTTTTCATTATTGGGAAATGAAGAATGGAAGCTTTTTGGAAAAATAAAATAA t899.nt (SEQ ID NO:56) TTGCCTCCGGAAGATATTATTTTTGAGAGTTCTTATGAGGTTGCAATTAAAAAAGCTCAAAAAT TGAATAAAAATGTTTTAATTTTGGTTGGTAGAGATATTAAAGAAAATTTAATAAAAGATTTTTT AAACTCTTTTACAAATGGTGAAATTATTCACAAAGTATCTAGAAAAAGTGTTTTTTTAGTTATTG ATAAGGATAATGAAATTTTTAATAAAATTAATCTACAAAAAAGTCCGACTATTTTTTTTGTTGA TTCTAAGAATGAGCAAATAAAGGCAGCTTATGTGGGAGCTGTTTTGAGCAGTGTTCAATTTGAT AAGGATTTTTTAAACTATGTTATGGGAGCTATAAAATCAACAAGTGTTTTAAAAAAGCAAAAAG ATTATGAAATTAATACTGCTGATGAGAGAACCTTTTTTTACAAAACATTAAAAGGTGATTGGCG ATTAAAGTTTAATGGTAAAGACAGAAAGCTTGTTCTTTTTGATACAGATCTTAAAGAATTTTTA GTTTTTAAAGATATTAATGAAAACAAGCTTTATGCTATTCCTAAGTCTAGGATTGGTAATATTTA TTTTTCATTATTGGGAAATGAAGAATGGAAGCTTTTTGGAAAAATAAAATAA f924.aa (SEQ ID NO:57) MQDRKFSFRKYFLISVFLIFIVSGITYFYSTQMLEKSQKCVEDNLDAKVKLVDMEDFYFDLNECLNM DDFFIPRPDFLNENLNKNLVVDGLIKNKFLDENFFKDLWIKKENLFNVDIEKENEKLIDKILEISK t924.aa (SEQ LD NO:58) TQMLEKSQKCVEDNLDAKVKLVDMEDFYFDLNECLNMDDFFIPRPDFLNENLNKNLVVDGLIKNK FLDENFFKDLWIKKENLFNVDIEKENEKLIDKILEISK f924.nt (SEQ ID NO:59) ATGCAAGATAGAAAGTTTAGTTTTAGAAAATATTTTTTAATTTCAGTATTTTTGATTTTTATTGT TTCTGGTATTACTTATTTCTATTCAACACAAATGTTGGAAAAATCTCAAAAGTGTGTTGAAGAC AATTTAGACGCTAAGGTTAAATTAGTTGATATGGAAGATTTTTATTTTGATTTAAATGAATGTCT AAATATGGATGATTTTTTTATTCCAAGACCTGATTTTTTAAATGAAAATTTAAATAAGAATTTAG TTGTTGATGGATTGATTAAAAATAAATTTCTTGATGAGAATTTTTTCAAGGATCTTTGGATTAAA AAGGAAAATTTATTTAACGTTGATATTGAGAAGGAGAATGAAAAATTAATAGATAAGATTTTA GAAATTTCCAAATGA t924.nt (SEQ ID NO:60) ACACAAATGTTGGAAAAATCTCAAAAGTGTGTTGAAGACAATTTAGACGCTAAGGTTAAATTA GTTGATATGGAAGATTTTTATTTTGATTTAAATGAATGTCTAAATATGGATGATTTTTTTATTCC AAGACCTGATTTTTTAAATGAAAATTTAAATAAGAATTTAGTTGTTGATGGATTGATTAAAAAT AAATTTCTTGATGAGAATTTTTTCAAGGATCTTTGGATTAAAAAGGAAAATTTATTTAACGTTG ATATTGAGAAGGAGAATGAAAAATTAATAGATAAGATTTTAGAAATTTCCAAATGA f925.aa (SEQ ID NO:61) MIRKYLIYISLLFIVFEVYSKPAFISQDDSYELDFSSGEVDISVNTNSKFNLSFKDESWIYIKSIENEAFI KLIGESYDNGAVFTFQTFKKEGKIKLVFTYQNVKDSSEFNKIIILKITKNFEVAIPQGVGGGSSRDNNI ETGNNLELGGGSISGATSKEIIVRALNLSYINDYKGAIDLLNKYNFNDDKYILLKAEIHYKNGDYLKS YENYLKLKSKYFQSIVFDLIRLAIELNIKEEVLENARYLVEKNVDFSESIYLEIFEFLVTRGEHEFALNF SSLYFPKYTNSSFSDKYSYLLGKLYESESKHKDFLKALHYYKLVIDNYPFSYYYERAKIRYLFLKRFF t925.aa (SEQ ID NO:62) KPAFISQDDSYELDFSSGEVDISVNTNSKFNLSFKDESWIYIKSIENEAFIKLIGESYDNGAVFTFQTFK KEGKIKLVFTYQNVKDSSEFNKIIILKITKNFEVAIPQGVGGGSSRDNNIETGNNLELGGGSISGATSK EIIVRALNLSYINDYKGAIDLLNKYNFNDDKYILLKAEIHYKNGDYLKSYENYLKLKSKYFQSIVFDL IRLAIELNIKEEVLENARYLVEKNVDFSESIYLEIFEFLVTRGEHEFALNFSSLYFPKYINSSFSDKYSYL LGKLYESESKHKDFLKALHYYKLVIDNYPFSYYYERAKIRYLFLKRFF f925.nt (SEQ ID NO:63) ATGATTAGAAAATATTTGATTTATATAAGTTTGCTATTTATTGTTTTTGAAGTTTACTCTAAGCC AGCTTTTATAAGTCAAGACGATTCGTATGAGCTTGATTTTAGTAGTGGAGAGGTAGATATTAGT GTAAATACCAATTCAAAATTTAATCTTTCTTTTAAAGATGAGTCTTGGATTTATATCAAAAGCAT TGAAAATGAAGCTTTTATTAAGTTAATTGGAGAATCTTATGATAACGGTGCTGTTTTTACTTTTC AGACTTTTAAAAAAGAAGGCAAAATTAAATTGGTTTTCACTTATCAAAATGTTAAAGATTCAAG TGAATTTAATAAAATAATTATCTTGAAAATTACAAAGAATTTTGAAGTTGCAATTCCACAAGGC GTTGGTGGTGGCTCTAGCAGGGACAATAACATTGAAACTGGTAATAATCTTGAACTTGGGGGG GGGAGTATTAGCGGGGCAACTTCTAAAGAGATTATTGTTAGGGCTTTAAATTTGTCCTACATAA ATGATTACAAAGGAGCAATAGATTTGCTTAATAAGTATAATTTCAATGACGATAAATATATTTT ATTGAAGGCGGAAATTCATTATAAAAATGGTGATTATTTAAAATCTTATGAAAATTATTTGAAA TTGAAGAGTAAATATTTTCAAAGCATTGTTTTTGATCTAATTAGGCTTGCTATAGAATTAAATAT TAAAGAAGAGGTTTTAGAGAACGCTAGATATTTAGTTGAAAAGAATGTTGATTTTTCTGAGAGC ATTTATCTTGAGATCTTTGAATTCTTAGTAACAAGGGGAGAGCATGAGTTTGCTTTAAATTTTA GCTCTCTTTACTTTCCTAAGTATATTAATTCAAGCTTTTCAGACAAATATAGTTATTTGTTGGGA AAACTTTATGAGTCTGAGAGCAAGCATAAAGATTTTTTAAAGGCTTTGCATTACTATAAATTGG TTATTGATAATTACCCTTTTAGTTATTATTATGAGAGAGCCAAGATAAGATATTTATTTTTAAAG CGGTTTTTTTAG t925.nt (SEQ ID NO:64) AAGCCAGCTTTTATAAGTCAAGACGATTCGTATGAGCTTGATTTTAGTAGTGGAGAGGTAGATA TTAGTGTAAATACCAATTCAAAATTTAATCTTTCTTTTAAAGATGAGTCTTGGATTTATATCAAA AGCATTGAAAATGAAGCTTTTATTAAGTTAATTGGAGAATCTTATGATAACGGTGCTGTTTTTA CTTTTCAGACTTTTAAAAAAGAAGGCAAAATTAAATTGGTTTTCACTTATCAAAATGTTAAAGA TTCAAGTGAATTTAATAAAATAATTATCTTGAAAATTACAAAGAATTTTGAAGTTGCAATTCCA CAAGGCGTTGGTGGTGGCTCTAGCAGGGACAATAACATTGAAACTGGTAATAATCTTGAACTTG GGGGGGGGAGTATTAGCGGGGCAACTTCTAAAGAGATTATTGTTAGGGCTTTAAATTTGTCCTA CATAAATGATTACAAAGGAGCAATAGATTTGCTTAATAAGTATAATTTCAATGACGATAAATAT ATTTTATTGAAGGCGGAAATTCATTATAAAAATGGTGATTATTTAAAATCTTATGAAAATTATT TGAAATTGAAGAGTAAATATTTTCAAAGCATTGTTTTTGATCTAATTAGGCTTGCTATAGAATT AAATATTAAAGAAGAGGTTTTAGAGAACGCTAGATATTTAGTTGAAAAGAATGTTGATTTTTCT GAGAGCATTTATCTTGAGATCTTTGAATTCTTAGTAACAAGGGGAGAGCATGAGTTTGCTTTTTAA ATTTTAGCTCTCTTTACTTTCCTAAGTATATTAATTCAAGCTTTTCAGACAAATATAGTTATTTG TTGGGAAAACTTTATGAGTCTGAGAGCAAGCATAAAGATTTTTTAAAGGCTTTGCATTACTATA AATTGGTTATTGATAATTACCCTTTTAGTTATTATTATGAGAGAGCCAAGATAAGATATTTATTT TTAAAGCGGTTTTTTTAG f929.aa (SEQ ID NO:65) MTKVLVVSAIALLSKDKELIPFYKFLFLFFFFTLLACSKVSKDFIVFNKDVKTSSRIDNPNSNVLEVNK MEDFFGDIIDLKGYKILSVQQENLNLDVYFEQVVLAQNFSNLNAYLFIIGFDPKIKAGTILFKTQIDID PKNSYNMYLEDITGDYDFNIVIQGFLKDKSVLYVFQKSVLNDVSSYRPIFFDKVNGTVLINKYARSS AYEENRSRESYPISLEKYEKVGEDLIISKIEKYEYSNVQGRYCLSSVSEKVGKIDNNIYKTLKNLSKD EVYKFLHGVWYDVHDYNKMHVKDIDEVLFLSFERQSSEINLFRKNSQEVAKIEYISKPAYNTLNVS AKSLFSDLIVYNFWIKIVDKENIEIKIDTSTNSYDNSGFSGTFKRFDENVLNVKKGSSDIYFIPSGNYV YKDKIYDFSYPHLTYIDENKIYYGIFNIFPLKNNFVLEYEIDMGSYKLVESFFLEHSERIVQKQKFSTII LNPIKILKDDVSLVKGQKLKLERIEKI t929.aa (SEQ ID NO:66) KDKELIPFYKFLFLFFFFTLLACSKVSKDFIVFNKDVKTSSRIDNPNSNVLEVNKMEDFFGDIIDLKGY KILSVQQENLNLDVYFEQVVLAQNFSNLNAYLFIIGFDPKIKAGTILFKTQIDIDPKNSYNMYLEDITG DYDFNIVIQGFLKDKSVLYVFQKSVLNDVSSYRPIFFDKVNGTVLINKYARSSAYEENRSRESYPISL EKYEKVGEDLIISKIEKYEYSNVQGRYCLSSVSEKVGKIDNNIYKTLKNLSKDEVYKFLHGVWYDV HDYNKMHVKDIDEVLFLSFERQSSEINLFRKNSQEVAKIEYISKPAYNTLNVSAKSLFSDLIVYNFWI KIVDKENIEIKIDTSTNSYDNSGFSGTFKRFDENVLNVKKGSSDIYFIPSGNYVYKDKIYDFSYPHLTY IDENKIYYGIFNIFPLKNNFVLEYEIDMGSYKLVESFFLEHSERIVQKQKTSTIILNPIKILKDDVSLVKG QKLKLERIEKI f929.nt (SEQ ID NO:67) ATGACAAAGGTTTTGGTTGTTAGTGCGATTGCTCTTCTGAGTAAGGATAAAGAATTAAT CCCATTTTATAAATTTTTGTTTTTATTCTTTTTTTTTACATTACTTGCTTGTTCCAAGGTAAGCAA AGATTTTATTGTTTTTAACAAAGATGTAAAGACTTCTTCCAGGATCGATAATCCAAATTCCAAT GTTTTAGAAGTTAATAAAATGGAAGATTTTTTTGGAGATATTATAGATTTAAAAGGTTATAAAA TTCTTTCAGTTCAGCAGGAAAATTTAAATTTAGATGTGTATTTTGAGCAGGTGGTTTTAGCTCAA AATTTTTCAAATCTTAATGCATATTTGTTTATTATTGGTTTTGATCCTAAAATTAAAGCTGGAAC GATTCTTTTTAAAACTCAAATAGATATTGATCCAAAAAATTCTTATAACATGTATCTTGAAGAT ATTACAGGTGATTATGATTTTAATATAGTTATTCAAGGATTTTTAAAAGATAAATCTGTTTTGTA TGTTTTTCAAAAATCTGTTTTAAATGATGTGTCTTCTTATAGGCCTATATTTTTTGACAAAGTTA ATGGAACTGTTCTTATTAATAAGTATGCAAGATCTTCAGCTTATGAAGAAAACAGATCAAGAGA AAGCTATCCTATTTCTTTAGAAAAATATGAAAAAGTGGGGGAAGATTTAATAATTAGCAAGATT GAAAAATATGAATATTCTAATGTTCAGGGTAGATATTGTCTTTCTTCTGTGAGCGAAAAAGTTG GTAAAATTGATAATAATATTTATAAAACTTTAAAGAATTTAAGCAAAGATGAAGTTTATAAATT TTTGCATGGAGTTTGGTATGATGTTCATGACTATAATAAAATGCATGTCAAAGATATTGATGAA GTTTTATTCTTGTCTTTGAAAGGCAATCAAGCGAGATTAATCTTTTCAGGAAAAATTCTCAAG AAGTTGCAAAGATTGAATATATTTCAAAACCTGCTTACAATACTCTTAATGTTAGTGCAAAGTC TCTTTTTTCAGATTTGATAGTTTATAACTTTTGGATCAAAATTGTAGATAAAGAAAACATTGAA ATCAAAATTGACACTAGCACAAATTCTTATGATAATAGTGGATTTTCGGGTACATTTAAGAGGT TTGATGAGAATGTCTTAAATGTTAAAAAAGGGAGTAGTGATATTTATTTTATTCCTAGTGGAAA TTACGTGTATAAGGATAAAATTTATGATTTTTCTTACCCCCATTTAACTTATATTGATGAGAATA AAATTTATTATGGCATTTTTAATATTTTTCCTTTAAAAAATAATTTTGTTCTTGAATATGAGATT GACATGGGTAGTTACAAGCTTGTTGAATCTTTTTTCCTTGAGCATAGCGAAAGAATTGTTCAAA AGCAAAAATTTTCTACAATCATTTTAAATCCTATTAAAATTTTAAAAGATGATGTAAGCTTAGTT AAAGGGCAAAAATTAAAGCTTGAGCGAATAGAAAAAATATGA t929.nt (SEQ ID NO:68) AAGGATAAAGAATTAATCCCATTTTATAAATTTTGTTTTTATTCTTTTTTTTTACATTACTTGCT TGTTCCAAGGTAAGCAAAGATTTTATTGTTTTTAACAAAGATGTAAAGACTTCTTCCAGGATCG ATAATCCAAATTCCAATGTTTTAGAAGTTAATAAAATGGAAGATTTTTTTGGAGATATTATAGA TTTAAAAGGTTATAAAATTCTTTCAGTTCAGCAGGAAAATTTAAATTTAGATGTGTATTTTGAG CAGGTGGTTTTAGCTCAAAATTTTTCAAATCTTAATGCATATTTGTTTATTATTGGTTTTGATCC TAAAATTAAAGCTGGAACGATTCTTTTTAAAACTCAAATAGATATTGATCCAAAAAATTCTTAT AACATGTATCTTGAAGATATTACAGGTGATTATGATTTTAATATAGTTATTCAAGGATTTTTAA AAGATAAATCTGTTTTGTATGTTTTTCAAAAATCTGTTTTAAATGATGTGTCTTCTTATAGGCCT ATATTTTTTGACAAAGTTAATGGAACTGTTCTTATTAATAAGTATGCAAGATCTTCAGCTTATGA AGAAAACAGATCAAGAGAAAGCTATCCTATTTCTTTAGAAAAATATGAAAAAGTGGGGGAAGA TTTAATAATTAGCAAGATTGAAAAATATGAATATTCTAATGTTCAGGGTAGATATTGTCTTTCTT CTGTGAGCGAAAAAGTTGGTAAAATTGATAATAATATTTATAAAACTTTAAAGAATTTAAGCAA AGATGAAGTTTATAAATTTTTGCATGGAGTTTGGTATGATGTTCATGACTATAATAAAATGCAT GTCAAAGATATTGATGAAGTTTTATTCTTGTCTTTTGAAAGGCAATCAAGCGAGATTAATCTTTT CAGGAAAAATTCTCAAGAAGTTGCAAAGATTGAATATATTTCAAAACCTGCTTACAATACTCTT AATGTTAGTGCAAAGTCTCTTTTTTCAGATTTGATAGTTTATAACTTTTGGATCAAAATTGTAGA TAAAGAAAACATTGAAATCAAAATTGACACTAGCACAAATTCTTATGATAATAGTGGATTTTCG GGTACATTTAAGAGGTTTGATGAGAATGTCTTAAATGTTAAAAAAGGGAGTAGTGATATTTATT TTATTCCTAGTGGAAATTACGTGTATAAGGATAAAATTTATGATTTTTCTTACCCCCATTTAACT TATATTGATGAGAATAAAATTTATTATGGCATTTTTAATATTTTTCCTTTAAAAAATAATTTTGT TCTTGAATATGAGATTGACATGGGTAGTTACAAGCTTGTTGAATCTTTTTTCCTTGAGCATAGCG AAAGAATTGTTCAAAAGCAAAAATTTTCTACAATCATTTTAAATCCTATTAAAATTTTAAAAGA TGATGTAAGCTTAGTTAAAGGGCAAAAATTAAAGCTTGAGCGAATAGAAAAAATATGA f933.aa (SEQ ID NO:69) MNKLLIFVLATFCVFSSFAQANDSKNGAFGMSAGEKLLVYETSKQDPIVPFLLNLFLGFGIGSFAQG DILGGSLILGFDAVGIGLILAGAYLDIKALDGITKKAAFQWTWGKGVMLAGVVTMAVTRLTEIILPF TFANSYNRKLKNSLNVALGGFEPSFDVAMGQSSALGFELSFKKSY t933.aa (SEQ ID NO:70) NDSKNGAFGMSAGEKLLVYETSKQDPIVPFLLNLFLGFGIGSFAQGDILGGSLILGFDAVGIGLILAG AYLDIKALDGITKKAAFQWTWGKGVMLAGVVTMAVTRLTEIILPFTFANSYNRKLKNSLNVALGG FEPSFDVAMGQSSALGFELSFKKSY f933.nt (SEQ ID NO:71) ATGAATAAACTTTTAATTTTTGTTTTGGCAACCTTTTGTGTTTTTTCTAGCTTTGCTCAAGCTAAT GATTCTAAAAATGGTGCGTTTGGGATGAGTGCTGGAGAAAAACTTTTGGTTTATGAAACTAGCA AGCAAGATCCTATTGTACCATTTTTATTGAACCTTTTTTTAGGGTTTGGAATAGGCTCCTTTGCT CAAGGAGATATTCTTGGAGGTTCTCTTATTCTTGGATTTGATGCGGTTGGTATAGGGCTTATACT TGCGGGGGCTTATTTGGATATCAAAGCGCTTGATGGTATTACTAAAAAAGCTGCTTTTCAATGG ACTTGGGGTAAGGGAGTTATGTTAGCAGGTGTGGTTACTATGGCTGTGACAAGATTAACAGAA ATTATTCTTCCATTTACATTTGCTAATAGTTATAATAGGAAGCTAAAAAATAGCCTTAATGTAGC TTTAGGAGGATTTGAACCTAGTTTTGATGTTGCAATGGGCCAATCCAGTGCTCTTGGGTTTGAA CTGTCTTTCAAAAAAAGCTATTAA t933.nt (SEQ ID NO:72) AATGATTCTAAAAATGGTGCGTTTGGGATGAGTGCTGGAGAAAAACTTTTGGTTTATGAAACTA GCAAGCAAGATCCTATTGTACCATTTTTATTGAACCTTTTTTTAGGGTTTGGAATAGGCTCCTTT GCTCAAGGAGATATTCTTGGAGGTTCTCTTATTCTTGGATTTGATGCGGTTGGTATAGGGCTTA TACTTGCGGGGGCTTATTTGGATATCAAAGCGCTTGATGGTATTACTAAAAAAGCTGCTTTTCA ATGGACTTGGGGTAAGGGAGTTATGTTAGCAGGTGTGGTTACTATGGCTGTGACAAGATTAAC AGAAATTATTCTTCCATTTACATTTGCTAATAGTTATAATAGGAAGCTAAAAAATAGCCTTAAT GTAGCTTTAGGAGGATTTGAACCTAGTTTTGATGTTGCAATGGGCCAATCCAGTGCTCTTGGGT TTGAACTGTCTTTCAAAAAAAGCTATTAA f940.aa (SEQ ID NO:73) MRKYIFIILIAVLLIGVNIKKIAAAANIDRHTNSTLGIDLSVGIPIFYNDLSKAYPTNLYPGGIGAIKYQY HILNNLAIGLELRYMFNFDINHSFNILNPDSSVGKIFYSVPITFSINYIFDIGELFQIPVFTNIGFSLNTYG DRNNNITNLRTFDALPTISFGSGILWNFNYKWAFGATASWWMMFEFGNSAKMAHFALVSLSVTVN VNKL t940.aa (SEQ ID NO:74) ANIDRHTNSTLGIDLSVGIPIFYNDLSKAYPTNLYPGGIGAIKYQYHILNNLAIGLELRYMFNFDINHS FNILNPDSSVGKIFYSVPITFSINYIFDIGELFQIPVFTNIGFSLNTYGDRNNNITNLRTFDALPTISFGSGI LWNFNYKWAFGATASWWMMFEFGNSAKMAHFALVSLSVTVNVNKL f940.nt (SEQ ID NO:75) ATGAGAAAGTATATTTTTATAATACTAATTGCAGTCTTGCTAATTGGTGTAAACATAAAAAAAA TTGCGGCCGCAGCCAATATTGATAGGCATACAAACTCCACTTTAGGAATAGATTTAAGTGTAGG AATCCCTATTTTTTACAACGACTTATCAAAAGCTTATCCTACCAATTTATATCCAGGAGGTATTG GGGCAATAAAATACCAGTACCATATTTTAAACAATTTAGCAATTGGACTTGAACTAAGGTATAT GTTTAACTTTGATATTAACCATTCTTTTAATATATTAAATCCAGATTCAAGTGTAGGTAAAATTT TTTATAGCGTGCCTATTACATTTTCAATAAATTATATATTTGATATAGGAGAATTATTTCAAATT CCAGTCTTCACAAATATAGGGTTTTCTCTTAATACATATGGAGATAGAAACAACAATATTACAA ATTTAAGAACTTTTGATGCACTCCCTACAATCTCTTTTGGATCTGGAATTTTATGGAACTTTAAC TATAAATGGGCTTTTGGAGCAACAGCATCTTGGTGGATGATGTTTGAATTTGGAAATTCTGCTA AAATGGCACATTTTGCACTTGTATCATTATCAGTTACAGTGAATGTAAATAAATTGTAG t940.nt (SEQ ID NO:76) GCCAATATTGATAGGCATACAAACTCCACTTTAGGAATAGATTTAAGTGTAGGAATCCCTATTT TTTACAACGACTTATCAAAAGCTTATCCTACCAATTTATATCCAGGAGGTATTGGGGCAATAAA ATACCAGTACCATATTTTAAACAATTTAGCAATTGGACTTGAACTAAGGTATATGTTTAACTTT GATATTAACCATTCTTTTAATATATTAAATCCAGATTCAAGTGTAGGTAAAATTTTTTATAGCGT GCCTATTACATTTTCAATAAATTATATATTTGATATAGGAGAATTATTTCAAATTCCAGTCTTCA CAAATATAGGGTTTTCTCTTAATACATATGGAGATAGAAACAACAATATTACAAATTTAAGAAC TTTTGATGCACTCCCTACAATCTCTTTTGGATCTGGAATTTTATGGAACTTTAACTATAAATGGG CTTTTGGAGCAACAGCATCTTGGTGGATGATGTTTGAATTTGGAAATTCTGCTAAAATGGCACA TTTTGCACTTGTATCATTATCAGTTACAGTGAATGTAAATAAATTGTAG f943.aa (SEQ ID NO:77) MKNQFLNSYFQLITTIFLISSITIAAEEITSTLKVPNGFKVEIFLNNTIEKPRGITSDQDGNIFIGSGSTFA YFVTKNRKIYTIAKTLQKPIGIDYWDNKLYISSVDKIYVVKNVKEEINKSIKSHKDYTWKMQIFALLP KNNSQMHSGRYIKVDSKNNKLIVNIGSQHNVKIPPKKEAVILSINLKTKKEEIVAFGVRNSVGFDFHP ISNEIYFSDNGQDGLGDNIPPDEINVITEYKEHTGFPYVFGKNQKNYGFYNKAPKNTKFIPSIYELPAH VAPLGIHFYRGNNFPKEYINKLFIAEHGSWNRSSPVGYKITTLDIDSKTRTARNYKTFLYGFLKHDKS KFGRPVDIITYYDGSILFTDDFGNKIYRVYYEKI t943.aa (SEQ ID NO:78) EITSTLKVPNGFKVEIFLNNTIEKPRGITSDQDGNIFIGSGSTFAYFVTKNRKIYTIAKTLQKPIGIDYW DNKLYISSVDKIYVVKNVKEEINKSIKSHKDYTWKMQIFALLPKNNSQMHSGRYIKVDSKNNKLIV NIGSQHNVKIPPKKEAVILSINLKTKKEEIVAFGVRNSVGFDFHPISNEIYFSDNGQDGLGDNIPPDEIN VITEYKEHFGFPYVFGKNQKNYGFYNKAPKNTKFIPSIYELPAHVAPLGIHFYRGNNFPKEYINKLFI AEHGSWNRSSPVGYKITTLDIDSKTRTARNYKTFLYGFLKHDKSKFGRPVDIITYDDGSILFTDDFGN KIYRVYYEKI f943.nt (SEQ ID NO:79) ATGAAAAATCAATTTTTAAATAGCTATTTTCAATTAATTACAACTATTTTCTTAATCTCATCTAT AACTATTGCAGCAGAAGAAATAACAAGCACACTAAAAGTTCCTAATGGATTTAAAGTCGAAAT TTTTTTAAACAATACAATTGAAAAACCTAGAGGAATCACAAGCGATCAAGATGGAAATATATTC ATAGGATCTGGAAGCACTTTTGCATACTTTGTAACAAAAAACAGAAAAATTTATACCATAGCAA AAACCCTGCAAAAACCTATTGGTATTGATTATTGGGATAATAAACTCTACATATCTTCTGTCGA TAAAATATATGTAGTTAAAAATGTAAAAGAAGAAATTAATAAAAGCATAAAATCACATAAAGA CTATACATGGAAAATGCAAATTTTTGCACTTTTGCCAAAAAATAATTCTCAAATGCACTCAGGA CGTTACATTAAAGTAGATTCTAAAAATAACAAATTAATAGTAAATATAGGATCCCAGCACAATG TTAAAATTCCCCCAAAAAAAGAAGCAGTAATCCTTAGTATTAATTTAAAAACAAAAAAGAAG AAATAGTAGCTTTTGGAGTGAGAAACTCAGTTGGGTTTGATTTTCACCCAATTAGCAATGAAAT ATATTTTAGCGACAATGGCCAAGACGGATTAGGAGACAACATTCCCCCAGATGAAATAAACGT AATAACCGAATATAAAGAACATTTTGGATTTCCCTATGTGTTTGGAAAAAATCAAAAAAATTAC GGTTTTTATAACAAAGCACCCAAAAACACTAAGTTTATCCCATCTATTTACGAACTTCCCGCAC ATGTAGCTCCACTTGGAATACACTTTACCGGGGAAATAACTTTCCAAAAGAATACATAAATAA ATTATTCATAGCAGAACACGGCTCGTGGAACAGATCTTCTCCTGTTGGCTACAAAATAACAACA CTAGACATTGATTCTAAAACCAGAACAGCAAGAAATTACAAGACTTTTTTATATGGATTTTAA AGCACGACAAATCTAAATTTGGACGCCCTGTTGATATAATCACATATTATGACGGTTCAATTCT TTTTACAGATGACTTTGGAAATAAAATATACAGAGTTTACTACGAAAAGATTTAA t943.nt (SEQ ID NO:80) GAAATAACAAGCACACTAAAAGTTCCTAATGGATTTAAAGTCGAAATTTTTTTAAACAA TACAATTGAAAAACCTAGAGGAATCACAAGCGATCAAGATGGAAATATATTCATAGGATCTGG AAGCACTTTTGCATACTTTGTAACAAAAAACAGAAAAATTTATACCATAGCAAAAACCCTGCAA AAACCTATTGGTATTGATTATTGGGATAATAAACTCTACATATCTTCTGTCGATAAAATATATGT AGTTAAAAATGTAAAAGAAGAAATTAATAAAAGCATAAAATCACATAAAGACTATACATGGAA AATGCAAATTTTTGCACTTTTGCCAAAAAATAATTCTCAAATGCACTCAGGACGTTACATTAAA GTAGATTCTAAAAATAACAAATTAATAGTAAATATAGGATCCCAGCACAATGTTAAAATTCCCC CAAAAAAAGAAGCAGTAATCCTTAGTATTAATTTAAAAACAAAAAAAGAAGAAATAGTAGCTT TTGGAGTGAGAAACTCAGTTGGGTTTGATTTTCACCCAATTAGCAATGAAATATATTTTAGCGA CAATGGCCAAGACGGATTAGGAGACAACATTCCCCCAGATGAAATAAACGTAATAACCGAATA TAAAGAACATTTTGGATTTCCCTATGTGTTTGGAAAAAATCAAAAAAATTACGGTTTTTATAAC AAAGCACCCAAAAACACTAAGTTTATCCCATCTATTACGAACTTCCCGCACATGTAGCTCCAC TTGGAATACACTTTTACCGGGGAAATAACTTTCCAAAAGAATACATAAATAAATTATTCATAGC AGAACACGGCTCGTGGAACAGATCTTCTCCTGTTGGCTACAAAATAACAACACTAGACATTGAT TCTAAAACCAGAACAGCAAGAAATTACAAGACTTTTTTATATGGATTTTTAAAGCACGACAAAT CTAAATTTGGACGCCCTGTTGATATAATCACATATTATGACGGTTCAATTCTTTTTACAGATGAC TTTGGAAATAAAATATACAGAGTTTACTACGAAAAGATTTAA f952.aa (SEQ ID NO:81) MNYARFAVLIVLLFFYIWFFIILRMKRTNLFLLEKIQNGAKILDIRSPKEYSKSHYLKSINIPFNNLFAK KDKLGDFESPIIVYGKSFNKSYEAKKVLKSMGFKNVFVAGTLKDMPQAKKEVG t952.aa (SEQ ID NO:82) RMKRTNLFLLEKIQNGAKILDIRSPKEYSKSHYLKSINIPFNNLFAKKDKLGDFESPIIVYGKSFNKSY EAKKVLKSMGFKNVFVAGTLKDMPQAKKEVG f952.nt (SEQ ID NO:83) ATGAATTATGCAAGATTTGCAGTATTAATAGTTCTGCTTTTTTTTTATATTTGGTTTTTTATTATC CTTAGGATGAAAAGAACTAATCTGTTTTTGTTAGAAAAATCCAAAATGGAGCAAAAATTTTGG ATATTCGGTCTCCCAAAGAATATAGCAAGTCTCATTATTTGAAGTCAATTAACATTCCTTTTAAT AATTTATTTGCTAAAAAGGATAAATTAGGTGATTTTGAGTCCCCAATAATTGTTTATGGTAAAA GTTTTAATAAGTCTTACGAGGCTAAAAAAGTTTTAAAAAGCATGGGATTTAAGAATGTGTTTGT TGCTGGAACCTTGAAAGACATGCCACAAGCAAAAAAAGAAGTTGGTTGA t952.nt (SEQ ID NO:84) AGGATGAAAAGAACTAATCTGTTTTTGTTAGAAAAAATCCAAAATGGAGCAAAAATTTTGGAT ATTCGGTCTCCCAAAGAATATAGCAAGTCTCATTATTTGAAGTCAATTAACATTCCTTTTAATAA TTTATTTGCTAAAAAGGATAAATTAGGTGATTTTGAGTCCCCAATAATTGTTTATGGTAAAAGT TTTAATAAGTCTTACGAGGCTAAAAAAGTTTTAAAAAGCATGGGATTTAAGAATGTGTTTGTTG CTGGAACCTTGAAAGACATGCCACAAGCAAAAAAAGAAGTTGGTTGA f378.aa (SEQ ID NO:85) MIKKFLLFAMLNIFLTNKAHSNEEIIEISTEIQKEKYIPFLISRGKTQLEDLVKYTLEINPELDKNYVNT VAKTYIDESLIEGVNYDIAYAQMLLETGALKFNGIVSKEQHNFSGIGATNNLTKGNSFSNITEGIKAH IQHLKAYASKQNIKSNMVDPRFYLVKRGSAPTIYDLTGKWAKDKLYDKKLKKILLELLEYNNANKS t378.aa (SEQ ID NO:86) NEEIIEISTEIQKEKYIPFLISRGKTQLEDLVKYTLEINPELDKNYVNTVAKTYIDESLIEGVNYDIAYA QMLLETGALKFNGIVSKEQHNFSGIGATNNLTKGNSFSNITEGIKAHIQHLKAYASKQNIKSNMVDP RFYLVKRGSAPTIYDLTGKWAKDKLYDKKLKKILLELLEYNNANKS f378.nt (SEQ ID NO:87) ATGATAAAAAAATTCTTGCTATTTGCAATGCTCAACATCTTTTTAACAAATAAAGCTCATAGTA ATGAAGAGATAATCGAAATAAGTACTGAAATACAAAAGGAAAAATATATTCCCTTTTTAATAA GTAGAGGAAAAACTCAACTAGAAGACCTTGTAAAATATACTCTAGAAATAAATCCAGAGCTTG ACAAAAACTATGTAAATACTGTTGCTAAAACCTATATAGACGAATCTTTGATTGAAGGGGTTAA TTATGACATTGCCTATGCTCAAATGTTACTAGAAACAGGAGCTCTAAAATTCAATGGAATAGTT TCAAAAGAACAACACAATTTTTCAGGAATAGGCGCTACTAATAATCTTACAAAAGGAAATTCTT TTTCCAATATTACAGAAGGAATTAAAGCTCATATTCAACATTTAAAAGCTTATGCTTCAAAACA AAATATCAAATCAAATATGGTTGATCCTAGATTTTACCTTGTTAAAAGAGGATCTGCTCCAACA ATATATGATTTGACTGGGAAATGGGCAAAAGACAAACTTTACGACAAAAAACTTAAAAAAATA TTATTAGAACTATTAGAATATAATAATGCAAATAAAAGCTAA t378.nt (SEQ ID NO:88) AATGAAGAGATAATCGAAATAAGTACTGAAATACAAAAGGAAAAATATATTCCCTTTTTAATA AGTAGAGGAAAAACTCAACTAGAAGACCTTGTAAAATATACTCTAGAAATAAATCCAGAGCTT GACAAAAACTATGTAAATACTGTTGCTAAAACCTATATAGACGAATCTTTGATTGAAGGGGTTA ATTATGACATTGCCTATGCTCAAATGTTACTAGAAACAGGAGCTCTAAAATTCAATGGAATAGT TTCAAAAGAACAACACAATTTTTCAGGAATAGGCGCTACTAATAATCTTACAAAAGGAAATTCT TTTTCCAATATTACAGAAGGAATTAAAGCTCATATTCAACATTTAAAAGCTTATGCTTCAAAAC AAAATATCAAATCAAATATGGTTGATCCTAGATTTTACCTTGTTAAAAGAGGATCTGCTCCAAC AATATATGATTTGACTGGGAAATGGGCAAAAGACAAACTTTACGACAAAAAACTTAAAAAAAT ATTATTAGAACTATTAGAATATAATAATGCAAATAAAAGCTAA f4.aa (SEQ ID NO:89) MKLFRRNVMIKMPSSFTIIFSLIVFVTILTYVIPAGKFDKEFKQMGDGSKREIIVAGTYQYVDRGSRGF LHPIMTILTAMSKGMEHAVEVIVFVLIVGGAYGIIMKTGAIDVGIYFLIKKLGHKDKLLIPLLMFIFSI GGTVTGMSEETLPFYFVMIPLIVALGYDSLVGAAIIALGAGVGTMASTVNPFATGIASAIASISLQDG FYFRIVLYFVSVLAAITYVCVYASKIKKDPSKSLVYSQKDEHYQYFVKKDGLSTGDNAQNALEFTFA HKLVLLLFGFMILILIFSIVNLGWWMQEMTMLYLGVAIISAFICKLGETEMWDAFVKGSESLLTAAL VIGLARGVMIVCDDGLITDTMLNAATNFLYNLPRPLFIILNEIIQIFIGFVVPSSSGHASLTMPIMAPLA DFLSIPRASVVIAMQTASGLINLITPTSGVIMAVLGISRLSYGTWFKFVLPLFMIEFFISILVIIANIYLSF t4.aa (SEQ ID NO:90) KFDKEFKQMGDGSKREIIVAGTYQYVDRGSRGTLHPIMTILTAMSKGMEHAVEVIVFVLIV GGAYGIIMKTGAIDVGIYFLIKKLGHKDKLLIPLLMFIFSIGGTVTGMSEETLPFYFVMIPLIVALGYD SLVGAAIIALGAGVGTMASTVNPFATGIASAIASISLQDGFYFRIVLYFVSVLAAITYVCVYASKIKKD PSKSLVYSQKDEHYQYFVKKDGLSTGDNAQNALEFTFAHKLVLLLFGFMILILIFSIVNLGWWMQE MTMLYLGVAIISAFICKLGETEMWDAFVKGSESLLTAALVIGLARGVMIVCDDGLITDTMLNAATN FLYNLPRPLFIILNEIIQIFIGFVVPSSSGHASLTMPIMAPLADFLSIPRASVVIAMQTASGLINLITPTSG VIMAVLGISRLSYGTWFKFVLPLFMIEFFISILVIIANIYLSF f4.nt (SEQ ID NO:91) ATGAAATTATTTAGGAGAAACGTTATGATCAAAATGCCAAGTAGTTTTACAATAATATTTTCTT TAATTGTATTTGTTACCATTTTAACGTATGTGATTCCTGCCGGTAAGTTTGATAAAGAATTTAAG CAAATGGGTGATGGATCTAAAAGGGAAATAATTGTTGCTGGAACTTATCAATATGTAGATCGA GGCTCTAGGGGATTTTTACATCCTATTATGACTATTTTAACCGCAATGTCAAAGGGGATGGAAC ATGCAGTTGAAGTTATTGTTTTTGTTTTAATTGTTGGGGGTGCTTATGGGATTATTATGAAAACT GGAGCAATAGATGTGGGAATTTATTTTTTAATCAAGAAGTTGGGGCACAAAGATAAGTTGCTTA TTCCTTTGTTAATGTTTATTTTTTCAATTGGTGGAACTGTAACCGGAATGAGTGAAGAGACCCTT CCTTTTTATTTTGTTATGATTCCCTTGATAGTAGCTTTGGGTTATGATAGTCTTGTTGGAGCGGC TATTATTGCTTTAGGAGCTGGAGTGGGAACTATGGCTTCTACTGTAAATCCATTTGCGACAGGA ATTGCATCTGCAATAGCTTCTATTAGCTTGCAGGATGGATTTTATTTTAGAATTGTTCTTTATTT TGTATCAGTATTGGCTGCTATAACCTATGTTTGTGTTTATGCGTCTAAAATTAAAAAGGATCCCT CAAAATCGCTTGTGTATTCTCAAAAAGATGAACATTATCAATATTTTGTTAAAAAAGATGGACT TTCTACCGGAGATAATGCTCAGAATGCTCTTGAGTTTACTTTTGCTCATAAATTAGTTTTACTTT TATTTGGATTTATGATATTGATTTTGATATTTAGCATTGTTAATCTTGGTTGGTGGATGCAAGAA ATGACAATGTTGTATCTTGGAGTTGCTATTATATCGGCTTTATTTGTAAATTAGGTGAAACTGA AATGTGGGATGCGTTTGTGAAAGGTTCTGAAAGTCTGCTAACCGCTGCTCTTGTTATTGGACTT GCTAGAGGTGTTATGATAGTATGTGATGATGGGTTGATTACAGATACTATGTTAAATGCTGCTA CTAATTTTTTATACAATCTTCCAAGACCCCTTTTTATCATATTGAATGAAATTATTCAAATATTT ATAGGATTTGTTGTTCCATCTTCATCAGGACATGCTAGTCTCACTATGCCAATAATGGCTCCTCT TGCCGATTTTTTGTCAATTCCAAGAGCTTCAGTTGTTATTGCCATGCAGACTGCATCTGGGCTTA TTAATTTGATAACACCTACCAGCGGAGTTATAATGGCTGTATTGGGGATATCCAGATTGAGTTA TGGTACGTGGTTTAAGTTTGTTTTACCATTATTTATGATTGAGTTTTTATCTCTATTTTAGTTAT TATAGCTAACATTTATTTAAGTTTTTAG t4.nt (SEQ ID NO:92) AAGTTTGATAAAGAATTTAAGCAAATGGGTGATGGATCTAAAAGGGAAATAATTGTTG CTGGAACTTATCAATATGTAGATCGAGGCTCTAGGGGATTTTTACATCCTATTATGACTATTTTA ACCGCAATGTCAAAGGGGATGGAACATGCAGTTGAAGTTATTGTTTTTGTTTTAATTGTTGGGG GTGCTTATGGGATTATTATGAAAACTGGAGCAATAGATGTGGGAATTTATTTTTTAATCAAGAA GTTGGGGCACAAAGATAAGTTGCTTATTCCTTTGTTAATGTTTATTTTTTCAATTGGTGGAACTG TAACCGGAATGAGTGAAGAGACCCTTCCTTTTTATTTTGTTATGATTCCCTTGATAGTAGCTTTG GGTTATGATAGTCTTGTTGGAGCGGCTATTATTGCTTTAGGAGCTGGAGTGGGAACTATGGCTT CTACTGTAAATCCATTTGCGACAGGAATTGCATCTGCAATAGCTTCTATTAGCTTGCAGGATGG ATTTTATTTTAGAATTGTTCTTTATTTTGTATCAGTATTGGCTGCTATAACCTATGTTTGTGTTTA TGCGTCTAAAATTAAAAAGGATCCCTCAAAATCGCTTGTGTATTCTCAAAAAGATGAACATTAT CAATATTTTGTTAAAAAAGATGGACTTTCTACCGGAGATAATGCTCAGAATGCTCTTGAGTTTA CTTTTGCTCATAAATTAGTTTTACTTTTATTTGGATTTATGATATTGATTTTGATATTTAGCATTG TTAATCTTGGTTGGTGGATGCAAGAAATGACAATGTTGTATCTTGGAGTTGCTATTATATCGGC TTTTATTTGTAAATTAGGTGAAACTGAAATGTGGGATGCGTTTGTGAAAGGTTCTGAAAGTCTG CTAACCGCTGCTCTTGTTATTGGACTTGCTAGAGGTGTTATGATAGTATGTGATGATGGGTTGA TTACAGATACTATGTTAAATGCTGCTACTAATTTTTTATACAATCTTCCAAGACCCCTTTTTATC ATATTGAATGAAATTATTCAAATATTTATAGGATTTGTTGTTCCATCTTCATCAGGACATGCTAG TCTCACTATGCCAATAATGGCTCCTCTTGCCGATTTTTTGTCAATTCCAAGAGCTTCAGTTGTTA TTGCCATGCAGACTGCATCTGGGCTTATTAATTTGATAACACCTACCAGCGGAGTTATAATGGC TGTATTGGGGATATCCAGATTGAGTTATGGTACGTGGTTTAAGTTTGTTTTACCATTATTTATGA TTGAGTTTTTTATCTCTATTTTAGTTATTATAGCTAACATTTATTTAAGTTTTTAG f43.aa (SEQ ID NO:93) MKYFYFLFFLLIFNVYAQNVNSPALPSPPLLPEITENKPVERENSSKGENFSNVGLDGKYVN DTILYGLDSQVTSIIKALKKSSDSQYNFSLKKRLEKTFNAELKREILELFISLKYSGGIDTANYILENYE SKRYSNALFGLAISYLKEFDDKEKLKKTLIDILENKEGNVVSIAAYYLGELNSLEYSKNMMEVFEKY SGNDGARREILIALGKMSAVDYQDRIYEISLDNYEGPSIKAAAIEALSYLASDKVTENADLYLQSNN NNLNVKLAIIASLSKDPSLKSKEILQGFLRDSDDNIRFKAINAIKGHRDSSAKDILIYKLKSDPSLKVRE ASAKALIDMDLGNIEIKNIMFDFKIDNNFKISMFSYLLDKDSLKALSIALEIVNKENINRPSNVLRGVA SMLAGKKGNFDNFYSKIIDSKNIDLRHLALKGAVYNKSSSLSDKLKKIKSETNSEYIKMLLKDY t43.aa (SEQ ID NO:94) LPSPPLLPEITENKPVERENSSKGENFSNVGLDGKYVNDTILYGLDSQVTSIIKALKKSSDSQYNFSLK KRLEKTFNAELKREILELFISLKYSGGIDTANYILENYESKRYSNALFGLAISYLKEFDDKEKLKKTLI DILENKEGNVVSIAAYYLGELNSLEYSKNMMEVFEKYSGNDGARREILIALGKMSAVDYQDRIYEIS LDNYEGPSIKAAAIEALSYLASDKVTENADLYLQSNNNNLNVKLAIIASLSKDPSLKSKEILQGFLRD SDDNIRFKAINAIKGHRDSSAKDILIYKLKSDPSLKVREASAKALIDMDLGNIEIKNIMFDFKIDNNFKI SMFSYLLDKDSIKALSIALEIVNKENINRPSNVLRGVASMLAGKKGNFDNFYSKIIDSKNIDLRHLAL KGAVYNKSSSLSDKLKKIKSETNSEYIKMLLKDY f43.nt (SEQ ID NO:95) ATGAAATACTTTTATTTTTTATTTTTTTTACTTATTTTTAATGTGTATGCTCAAAATGTT AATTCTCCAGCTCTTCCTAGTCCGCCTTTGTTGCCCGAAATTACAGAAAATAAGCCTGTTGAGA GAGAAAATTCTTCTAAGGGAGAGAATTTTTCTAATGTTGGTTTAGATGGTAAGTATGTTAACGA TACAATTCTTTATGGGCTTGATAGTCAAGTGACAAGCATTATAAAAGCTCTTAAAAAATCAAGC GATAGTCAATATAATTTTTCTCTTAAAAAAAGACTTGAGAAAACTTTTAATGCTGAGCCTAAAA GGGAAATACTTGAATTGTTTATTTCTCTTAAGTATTCGGGGGGCATTGATACAGCAAATTATAT TCTTGAAAATTATGAGAGTAAAAGATATTCAAACGCTTTATTTGGCTTGGCAATTTCGTATCTTA AGGAGTTTGATGATAAAGAAAAATTAAAAAAAACTCTTATTGACATTCTTGAAAATAAAGAGG GCAATGTGGTATCTATTGCAGCTTATTATTTAGGAGAGCTTAATTCTCTTGAGTATTCTAAAAAC ATGATGGAAGTTTTTGAAAAATATTCTGGAAATGATGGGGCTAGAAGAGAAATACTTATTGCTC TTGGAAAAATGTCCGCTGTTGATTATCAGGATAGAATTTATGAAATTTCGCTAGATAATTACGA GGGCCCATCAATTAAGGCTGCTGCAATCGAAGCGTTGTCATATCTTGCTTCAGATAAAGTAACT GAAAATGCTGATTTGTATCTTCAGAGTAATAACAATAATTTAAATGTTAAATTAGCTATTATTG CTTCTTTGTCCAAAGATCCTTCTTTAAAGTCTAAAGAGATTTTACAAGGATTTTTAAGAGATTCT GATGATAATATTAGGTTTAAAGCTATTAATGCAATCAAAGGACATAGGGACTCTTCTGCAAAGG ATATTTTGATTTATAAGCTTAAAAGCGATCCATCTCTTAAAGTTAGGGAGGCTTCTGCTAAGGC CTTAATTGATATGGATCTTGGGAATATTGAGATAAAAAACATTATGTTTGATTTTAAGATTGAC AATAATTTTAAAATTTCAATGTTTAGTTACCTTTTAGATAAGGATTCTCTAAAAGCATTGTCAAT TGCTTTAGAAATTGTTAATAAAGAAAATATTAATAGACCCTCAAATGTTTTAAGGGGCGTTGCT TCAATGTTGGCTGGTAAAAAGGGTAATTTTGATAATTTTTATTCTAAAATCATTGACAGCAAAA ATATTGATTTAAGGCATTTAGCATTAAAAGGAGCTGTTTATAATAAATCTTCATCGCTTTCTGAT AAGCTTAAAAAAATTAAAAGTGAAACGAACTCCGAATATATTAAAATGCTTTTAAAAGATTATT GA t43.nt (SEQ ID NO:96) CTTCCTAGTCCGCCTTTGTTGCCCGAAATTACAGAAAATAAGCCTGTTGAGAGAGAAAA TTCTTCTAAGGGAGAGAATTTTTCTAATGTTGGTTTAGATGGTAAGTATGTTAACGATACAATT CTTTATGGGCTTGATAGTCAAGTGACAAGCATTATAAAAGCTCTTAAAAAATCAAGCGATAGTC AATATAATTTTTCTCTTAAAAAAAGACTTGAGAAAACTTTTAATGCTGAGCTTAAAAGGGAAAT ACTTGAATTGTTTATTPCTCTTAAGTATTCGGGGGGCATTGATACAGCAAATTATATTCTTGAAA ATTATGAGAGTAAAAGATATTCAAACGCTTTATTTGGCTTGGCAATTTCGTATCTTAAGGAGTT TGATGATAAAGAAAAATTAAAAAAAACTCTTATTGACATTCTTGAAAATAAAGAGGGCAATGT GGTATCTATTGCAGCTTATTATTTAGGAGAGCTTAATTCTCTTGAGTATTCTAAAAACATGATG GAAGTTTTTGAAAAATATTCTGGAAATGATGGGGCTAGAAGAGAAATACTTATTGCTCTTGGAA AAATGTCCGCTGTTGATTATCAGGATAGAATTTATGAAATTTCGCTAGATAATTACGAGGGCCC ATCAATTAAGGCTGCTGCAATCGAAGCGTTGTCATATCTTGCTTCAGATAAAGTAACTGAAAAT GCTGATTTGTATCTTCAGAGTAATAACAATAATTTAAATGTTAAATTAGCTATTATTGCTTCTTT GTCCAAAGATCCTTCTTTAAAGTCTAAAGAGATTTTACAAGGATTTTTAAGAGATTCTGATGAT AATATTAGGTTTAAAGCTATTAATGCAATCAAAGGACATAGGGACTCTTCTGCAAAGGATATTT TGATTTATAAGCTTAAAAGCGATCCATCTCTTAAAGTTAGGGAGGCTTCTGCTAAGGCCTTAAT TGATATGGATCTTGGGAATATTGAGATAAAAAACATTATGTTTGATTTTAAGATTGACAATAAT TTTAAAATTTCAATGTTTAGTTACCTTTTAGATAAGGATTCTCTAAAAGCATTGTCAATTGCTTT AGAAATTGTTAATAAAGAAAATATTAATAGACCCTCAAATGTTTTAAGGGGCGTTGCTTCAATG TTGGCTGGTAAAAAGGGTAATTTTGATAATTTTTATTCTAAAATCATTGACAGCAAAAATATTG ATTTAAGGCATTTAGCATTAAAAGGAGCTGTTTATAATAAATCTTCATCGCTTTCTGATAAGCTT AAAAAAATTAAAAGTGAAACGAACTCCGAATATATTAAAATGCTTTTAAAAGATTATTGA f50.aa (SEQ ID NO:97) MKFVLNNLFKGCLICFFLFFSCLTTDRSIQDSHISDIVEKKKEAVIIDDNNVVLGSNEGKFKR DYLIGLKDNESFFLSDAFLKENNFYFKKARESYAKKNIGLTNYYLNKIVTNENQHSRELLAKANLFF GYVNYENGFYDLSEYNFDLFLKDYKYSHASLRLAELKYLVKEKSDAISAFKEINEFSISGYDREIYGF LSNKLGVSHLNLESLGFLDNSVFDTFVFNDNIFVTNILGGLLRYNIKKNDCRVYLKDKKSIFLNGIRG FADYNGTIYIGGKNVVYYIDDVDGDLKQINYPGNADFSNVQVLLAVKNGIFVGTLNSGLWFYDLK NWKNIPLGSNKISSLCFDSLKNLLLVGTVDKAIYSVNVDNLKKIEHLDFFSKNDNEKNINFIKEYKDS YFVGTYGGGLFELNLNKNSYKKHVIANNIDVNYFMDMEIKDKKLLFATFDHGLLIYDSENDNWDY FGPNNGLLNLNLIKVSRFENYVILGTINNGLVFVDENIKKQL t50.aa (SEQ ID NO:98) CLTTDRSIQDSHISDIVEKKKEAVIIDDNNVVLGSNEGKFKRDYLIGLKDNESFFLSDAFLKE NNFYFKKARESYAKKNIGLTNYYLNKIVTNENQHSRELLAKANLFFGYVNYENGFYDLSEYNFDLF LKDYKYSHASLRLAELKYLVKEKSDAISAFKEINEFSISGYDREIYGFLSNKLGVSHLNLESLGFLDNS VFDTFVFNDNIFVTNILGGLLRYNIKKNDCRVYLKDKKSIFLNGIRGFADYNGTIYIGGKNVVYYIDD VDGDLKQINVPGNADFSNVQVLLAVKNGIFVGTLNSGLWFYDLKNWKNIPLGSNKISSLCFDSLKN LLLVGTVDKAIYSVNVDNLKKIEHLDFFSKNDNEKNINFIKEYKDSYFVGTYGGGLFELNLNKNSYK KHVIANNIDVNYFMDMEIKDKKLLFATFDHGLLIYDSENDNWDYFGPNNGLLNLNLIKVSRFENYV ILGTINNGLVTVDENIKKQL f50.NT (SEQ ID NO:99) ATGAAATTTGTTTTGAATAATTTATTTAAAGGTTGTCTTATATGTTTTTTCTTGTTTTTT TCCTGCCTTACTACAGATAGATCTATTCAAGATTCTCATATTAGTGATATTGTAGAGAAGAAAA AAGAAGCAGTCATTATTGATGATAATAATGTTGTTCTTGGGAGTAATGAGGGTAAATTTAAAAG AGACTATTTGATAGGATTAAAAGATAATGAATCTTTTTTTCTTAGTGATGCTTTTTTAAAAGAA AATAATTTTTATTTTAAAAAGCCAGGGAAAGTTATGCTAAAAAAAATATTGGCTTGACAAATT ATTATTTGAATAAAATAGTAACTAATGAGAATCAGCACAGCAGAGAATTGCTAGCTAAAGCGA ATTTGTTTTTTGGATATGTAAATTATGAGAATGGTTTTTATGATCTTTTCCGAATATAATTTTGAT CTATTTTTAAAAGACTATAAATATTCTCATGCTAGTTTAAGATTAGCTGAATTAAAATATCTTGT TAAAGAAAAATCTGATGCAATTTCTGCATTTAAAGAGATTAATGAATTTTCTATCTCAGGTTAT GATAGAGAGATTTATGGCTTTTTAAGTAATAAACTTGGAGTAAGTCATTTAAACTTAGAGTCTT TAGGATTTCTTGACAACAGCGTTTTGATACATTTGTCTTTAATGACAATATATTTGTAACTAAT ATATTGGGAGGGCTTTTAAGATATAATATTAAAAAAAATGATTGTAGAGTCTATCTTAAGGATA AAAAAAGCATTTTTTTAAATGGCATTAGGGGTTTTGCGGATTATAATGGAACAATTTATATTGG TGGTAAAAATGTTGTTTATTATATAGATGATGTTGATGGGGATTTAAAGCAAATAAATGTTCCC GGTAATGCTGATTTTAGCAATGTACAAGTTTTGCTTGCTGTTAAAAATGGAATATTTGTTGGCA CTCTAAATTCTGGATTATGGTTTTATGATTTAAAAAATTGGAAAAATATACCGCTTGGATCTAA TAAAATTTCTTCACTCTGCTTTGATAGTTTAAAAAATTTATTATTAGTTGGAACAGTTGACAAGG CTATTTATAGTGTTAATGTCGATAATTTGAAAAAGATTGAACATTTGGATTTTTTTAGCAAAAA TGATAATGAAAAAAATATTAATTTTATAAAAGAATATAAAGATAGTTATTTTGTTGGAACATAT GGTGGGGGTCTTTTTGAATTAAATTTAAATAAAAATAGTTACAAAAAGCACGTTATTGCCAATA ATATTGATGTTAATTATTTTATGGATATGGAGATTAAAGATAAAAAGCTATTGTTTGCAACCTT TGATCATGGGTTATTGATTTATGATTCTGAAAATGACAACTGGGATTATTTTGGACCCAATAAT GGGCTTCTTAATTTGAATTTAATAAAAGTTTCTAGATTTGAAAATTATGTCATACTGGGCACTAT TAATAACGGTTTGGTTTTTGTAGATGAAAATATTAAAAAACAGTTATGA t50.nt (SEQ ID NO:100) TGCCTTACTACAGATAGATCTATTCAAGATTCTCATATTAGTGATATTGTAGAGAAGAAAAG AAGCAGTCATTATTGATGATAATAATGTTGTTCTTGGGAGTAATGAGGGTAAATTTAAAAGAGA CTATTTGATAGGATTAAAAGATAATGAATCTTTTTTTCTTAGTGATGCTTTTTTAAAAGAAAATA ATTTTTATTTTAAAAAAGCCAGGGAAAGTTATGCTAAAAAAAATATTGGCTTGACAAATTATTA TTTGAATAAAATAGTAACTAATGAGAATCAGCACAGCAGAGAATTGCTAGCTAAAGCGAATTT GTTTTTTGGATATGTAAATTATGAGAATGGTTTTTATGATCTTTCCGAATATAATTTTGATCTAT TTTTAAAAGACTATAAATATTCTCATGCTAGTTTAAGATTAGCTGAATTAAAATATCTTGTTAAA GAAAAATCTGATGCAATTTCTGCATTTAAAGAGATTAATGAATTTTCTATCTCAGGTTATGATA GAGAGATTTATGGCTTTTTAAGTAATAAACTTGGAGTAAGTCATTTAAACTTAGAGTCTTTAGG ATTTCTTGACAACAGCGTTTTTGATACATTTGTCTTTAATGACAATATATTTGTAACTAATATAT TGGGAGGGCTTTTAAGATATAATATTAAAAAAAATGATTGTAGAGTCTATCTTAAGGATAAAAA AAGCATTTTTTAAATGGCATTAGGGGTTTTGCGGATTATAATGGAACAATTTATATTGGTGGT AAAAATGTTGTTTATTATATAGATGATGTTGATGGGGATTTAAAGCAAATAAATGTTCCCGGTA ATGCTGATTTTAGCAATGTACAAGTTTTGCTTGCTGTTAAAAATGGAATATTTGTTGGCACTCTA AATTCTGGATTATGGTTTTATGATTTAAAAAATTGGAAAAATATACCGCTTGGATCTAATAAAA TTTCTTCACTCTGCTTTGATAGTTTAAAAAATTTATTATTAGTTGGAACAGTTGACAAGGCTATT TATAGTGTTAATGTCGATAATTTGAAAAAGATTGAACATTTGGATTTTTTTAGCAAAAATGATA ATGAAAAAAATATTAATTTTATAAAAGAATATAAAGATAGTTATTTTGTTGGAACATATGGTGG GGGTCTTTTTGAATTAAATTTAAATAAAAATAGTTACAAAAAGCACGTTATTGCCAATAATATT GATGTTAATTATTTTATGGATATGGAGATTAAAGATAAAAAGCTATTGTTTGCAACCTTTGATC ATGGGTTATTGATTTATGATTCTGAAAATGACAACTGGGATTATTTTGGACCCAATAATGGGCT TCTTAATTTGAATTTAATAAAAGTTTCTAGATTTGAAAATTATGTCATACTGGGCACTATTAATA ACGGTTTGGTTTTTGTAGATGAAAATATTAAAAAACAGTTATGA f65.aa (SEQ ID NO:101) MHIFKNVPFQINLILFLLVSVAKINASSKFYYAEQWYVIFNSQMKKKPENYKKNIFFLQKALKYPFG NPKYSLTKIETKEQWEKYKLLFKMHVNLLLVRQNLHLGDLFDTRNLYFFKTPEKDGIISNLEKSKKL YKLAINYYSEALKYHKKLENYTTVKLENDGITNWEDEYHKISLKELNYYDIIKKELLRIDETKAFFE QGPNYY t65.aa (SEQ ID NO:102) KINASSKFYYAEQWYVIFNSQMKKKPENYKKNIFFLQKALKYPFGNPKYSLTKIETKEQWEKYKLL FKMHVNLLLVRQNLHLGDLFDTRNLYFFKTPEKDGIISNLEKSKKLYKLAINYYSEALKYHKKLEN YTTVKLENDGITNWEDEYHKISLKELNYYDIIKKELLRIDETKAFFEQGPNYY f65.nt (SEQ ID NO:103) ATGCATATTTTCAAAAATGTCCCCTTCCAAATAAATTTAATTTTATTTCTTTTAGTATCAGTTGC AAAGATAAATGCATCGTCCAAATTTTATTACGCAGAACAATGGTATGTAATTTTTAATTCTCAA ATGAAAAAAAAACCTGAAAACTATAAAAAAAATATATTTTTTCTTCAAAAAGCCTTAAAATACC CATTTGGAAATCCAAAATATTCTCTAACTAAAATAGAAACCAAAGAACAGTGGGAAAAATATA AACTTCTTTTCAAAATGCATGTAAACTTGCTTCTACTTAGGCAAAATTTACATTTAGGAGATTTA TTCGACACAAGAAATTTATATTTTTTCAAAACTCCAGAAAAAGATGGAATTATTTCCAATCTAG AAAAATCAAAAAAATTATATAAACTAGCTATTAATTACTACAGCGAAGCACTAAAATACCACAA AAAACTTGAAAATTACACAACTGTTAAACTAGAAAACGATGGAATAACAAACTGGGAAGATGA ATATCATAAAATTTCTCTTAAAGAGCTTAATTACTATGACATTATTAAAAAAGAACTACTAAGA ATTGACGAAACTAAAGCATTTTTTGAACAAGGGCCAAACTATTATTAA t65.nt (SEQ ID NO:104) AAGATAAATGCATCGTCCAAATTTTATTACGCAGAACAATGGTATGTAATTTTTAATTCTCAAA TGAAAAAAAAACCTGAAAACTATAAAAAAAATATATTTTTTCTTCAAAAAGCCTTAAAATACCC ATTTGGAAATCCAAAATATTCTCTAACTAAAATAGAAACCAAAGAACAGTGGGAAAAATATAA ACTTCTTTTCAAAATGCATGTAAACTTGCTTCTAGTTAGGCAAAATTTACATTTAGGAGATTTAT TCGACACAAGAAATTTATATTTTTTCAAAACTCCAGAAAAAGATGGAATTATTTCCAATCTAGA AAAATCAAAAAAATTATATAAACTAGCTATTAATTACTACAGCGAAGCACTAAAATACCACAAA AAACTTGAAAATTACACAACTGTTAAACTAGAAAACGATGGAATAACAAACTGGGAAGATGAA TATCATAAAATTTCTCTTAAAGAGCTTAATTACTATGACATTATTAAAAAAGAACTACTAAGAA TTGACGAAACTAAAGCATTTTTTGAACAAGGGCCAAACTATTATTAA f8.aa (SEQ ID NO:105) MKNINRLILLILTTHTLLFSCALIADNKSKNLSTSEIILTQKTLLESSLIKNPSNVEYRIPISSIQEILNNN NDSFLIKKTAAKIKISPQKLEEIKNYLNAYKNYLNNETEWIKFIDQSSVNGNLTIKIDTAFEKKTNFNH TNSDNENLTELIELQMHLEKEILNLIEQTFHDKNLGYIQLSHINSFFPQENINSITKEIIDGKEYIAPHIIA NQLLKIKDKKYFEQFMHFLKVENSKIKTIIEKQKISDLHNELYYSKQSPPRRRKRSTADSDNNNKYDI IPKIIDPNTGIEITPKNLRSILSNGDIILIKPKIDWTEFFYFWQHVGIFDEEKYEATKKIATNGIDSFDIKSI ITSNQIKFDTASTQGSGYEKLSTYVQSRILKIFSPITDIRTIQKAINFGRSRYIDNNFGYMVPLISSNLWT DSFNLEEIHNKTYCSLMVDRIYKIAGLNVSRNYEISGIITPGEINAAAYNFYMSYTIAGILPSVLPKRLI KPTLKEKFIGYNKEIVDAIELKKSKEKIFGRACNITNLWCSGS t8.aa (SEQ ID NO:106) CALIADNKSKNLSTSEIILTQKTLLESSLIKNPSNVEYRIPISSIQEILNNNNDSFLIKKTAAKIKISPQKL EEIKNYLNAYKNYLNNETEWIKFIDQSSVNGNLTIKIDTAFEKKTNFNHTNSDNENLTELIELQMHLE KEILNLIEQTFHDKNLGYIQLSHINSFFPQENINSITKEIIDGKEYIAPHIIANQLLKIKDKKYFEQFMHF LKVENSKIKTIIEKQKISDLHNELYYSKQSPPRRRKRSTADSDNNNKYDIIPKIIDPNTGIEITPKNLRSI LSNGDIILIKPKIDWTEFFYFWQHVGIFDEEKYEATKKIAFNGIDSFDIKSIITSNQIKFDTASTQGSGY EKLSTYVQSRILKIFSPITDIRTIQKAINFGRSRYIDNNFGYMVPLISSNLWTDSFNLEEIHNKTYCSLM VDRIYKIAGLNVSRNYEISGIITPGEINAAAYNFYMSYTIAGILPSVLPKRLIKPTLKEKFIGYNKEIVD AIELKKSKEKIFGRACNITNLWCSGS f8.nt (SEQ ID NO:107) ATGAAGAATATTAATAGATTAATATTATTAATATTAACTACACACACTTTATTATTCTCTTGTGC CTTAATTGCAGATAATAAGTCAAAAAATTTAAGCACATCAGAAATCATATTAACACAAAAAACA CTACTAGAAAGCTCTTTAATAAAAAATCCTTCTAATGTAGAATATCGAATACCAATATCCAGTA TCCAAGAAATTTTAAACAATAACAATGATTCTTTTTTAATAAAAAAAACAGCAGCAAAAATCAA AATAAGCCCTCAAAAACTTGAAGAAATAAAAAACTATCTAAATGCTTATAAAAATTATCTAAAT AATGAAACAGAATGGATAAAGTTTATAGATCAAAGTAGCGTCAATGGAAATTTAACAATTAAA ATTGATACTGCTTTTGAAAAAAAAACAAATTTTAATCATACAAATTCAGATAATGAAAATTTAA CAGAACTAATAGAACTACAAATGCATCTGGAAAAAGAAATTTTAAACTTAATTGAGCAAACATT TCATGATAAAAATTTAGGATATATACAATTAAGTCACATCAACTCATTCTTTCCTCAAGAAAAT ATAAACTCAATAACAAAAGAAATAATAGATGGAAAAGAATATATTGCACCGCACATAATAGCA AATCAATTATTAAAAATAAAAGATAAAAATATTTTGAACAATTTATGCACTCTTTTTAAAAGTTG AAAACAGCAAAATAAAAACAATAATTGAAAAACAAAAAAATTTCAGATCTTCACAATGAACTGT ATTATTCAAAACAATCCCCGCCCAGAAGAAGAAAAAGGTCAACTGCCGATTCCGATAATAACA ATAAATACGATATAATACCAAAAATAATAGACCCAAATACAGGCATTGAAATAACTCCTAAAA ATTTAAGATCTATTTTATCAAATGGCGACATAATACTAATAAAACCAAAAATAGATTGGACAGA ATTTTTTTATTTTTGGCAACATGTGGGAATATTTGATGAAGAAAAATATGAAGCCACTAAAAAA ATTGCATTCAATGGAATTGATAGCTTTGATATAAAATCAATAATTACAAGCAATCAAATCAAAT TCGATACAGCATCTACTCAAGGTTCAGGATACGAAAAGCTTTCAACATACGTACAATCAAGAAT ATTAAAAATATTCTCACCAATAACAGACATAAGAACAATTCAAAAAGCTATTAATTTTGGAAGA AGTAGATACATTGACAATAACTTTGGATATATGGTTCCATTAATATCCTCTAATTTATGGACAG ATTCATTCAATCTTGAAGAAATTCACAACAAAACCTATTGCTCTTTAATGGTTGATAGAATATA TAAAATAGCAGGACTTAATGTATCAAGAAATTACGAAATTTCGGGAATAATTACTCCTGGAGAA ATAAATGCAGCAGCTTACAATTTTTACATGTCTTATACGATTGCAGGAATACTTCCAAGCGTGC TTCCAAAAAGGCTCATTAAACCAACATTAAAAGAAAAATTCATTGGTTACAATAAAGAAATAGT AGATGCAATAGAATTAAAAAAATCGAAAGAAAAAATTTTTGGGAGAGCTTGCAACATTACAAA TCTCTGGTGCTCAGGAAGTTAA t8.nt (SEQ ID NO:108) TGTGCCTTAATTGCAGATAATAAGTCAAAAAATTTAAGCACATCAGAAATCATATTAACACAAA AAACACTACTAGAAAGCTCTTTAATAAAAAATCCTTCTAATGTAGAATATCGAATACCAATATC CAGTATCCAAGAAATTTTAAACAATAACAATGATTCTTTTTTAATAAAAAAAACAGCAGCAAAA ATCAAAATAAGCCCTCAAAAACTTGAAGAAATAAAAAACTATCTAAATGCTTATAAAAATTATC TAAATAATGAAACAGAATGGATAAAGTTTATAGATCAAAGTAGCGTCAATGGAAATTTAACAA TTAAAATTGATACTGCTTTTGAAAAAAAAACAAATTTTAATCATACAAATTCAGATAATGAAAA TTTAACAGAACTAATAGAACTACAAATGCATCTGGAAAAAGAAATTTTAAACTTAATTGAGCAA ACATTTCATGATAAAAATTTAGGATATATACAATTAAGTCACATCAACTCATTCTTTCCTCAAGA AAATATAAACTCAATAACAAAAGAAATAATAGATGGAAAAGAATATATTGCACCGCACATAAT AGCAAATCAATTATTAAAAATAAAAGATAAAAAATATTTTGAACAATTTATGCACTTTTTAAAA GTTGAAAACAGCAAAATAAAAACAATAATTGAAAAACAAAAAATTTCAGATCTTCACAATGAA CTGTATTATTCAAAACAATCCCCGCCCAGAAGAAGAAAAAGGTCAACTGCCGATTCCGATAATA ACAATAAATACGATATAATACCAAAAATAATAGACCCAAATACAGGCATTGAAATAACTCCTA AAAATTTAAGATCTATTTTATCAAATGGCGACATAATACTAATAAAACCAAAAATAGATTGGAC AGAATTTTTTTATTTTTGGCAACATGTGGGAATATTTGATGAAGAAAAATATGAAGCCACTAAA AAAATTGCATTCAATGGAATTGATAGCTTTGATATAAAATCAATAATTACAAGCAATCAAATCA AATTCGATACAGCATCTACTCAAGGTTCAGGATACGAAAAGCTTTCAACATACGTACAATCAAG AATATTAAAAATATTCTCACCAATAACAGACATAAGAACAATTCAAAAAGCTATTAATTTTGGA AGAAGTAGATACATTGACAATAACTTTGGATATATGGTTCCATTAATATCCTCTAATTTATGGA CAGATTCATTCAATCTTGAAGAAATTCACAACAAAACCTATTGCTCTTTAATGGTTGATAGAAT ATATAAAATAGCAGGACTTAATGTATCAAGAAATTACGAAATTTCGGGAATAATTACTCCTGGA GAAATAAATGCAGCAGCTTACAATTTTTACATGTCTTATACGATTGCAGGAATACTTCCAAGCG TGCTTCCAAAAAGGCTCATTAAACCAACATTAAAAGAAAAATTCATTGGTTACAATAAAGAAAT AGTAGATGCAATAGAATTAAAAAAATCGAAAGAAAAAATTTTTGGGAGAGCTTGCAACATTAC AAATCTCTGGTGCTCAGGAAGTTAA f82.aa (SEQ ID NO:109) MTRVFSKFFLFFCFSMLLFANSEDSNEKDIVSKDENPVFENEVLGYWVGYNDVSNIKNSIIYIYKYN GEVYGRILTIIKDGKKYDAKNPSGDTVVGFENLAIEGLDFMWGLKYSSSSKKWDRGKIIDPKNGKIY NSEMRVDSKTGNLITKGKVWIFGRSKIWTRAKDDEIPKLDLHNLVPAPPVKK t82.aa (SEQ ID NO:110) EDSNEKDIVSKDENPVFENEVLGYWVGYNDVSNIKNSIIYIYKYNGEVYGRILTIIKDGKKYDAKNP SGDTVVGFENLAIEGLDFMWGLKYSSSSKKWDRGKIIDPKNGKIYNSEMRVDSKTGNLITKGKVWI FGRSKIWTRAKDDEIPKLDLHNLVPAPPVKK f82.nt (SEQ ID NO:111) ATGACTAGAGTTTTTTCAAAGTTTTTTCTTTTTTTTTGTTTTTCAATGCTTTTATTTGCAAATTCA GAAGATTCAAATGAAAAGGACATTGTTAGCAAGGATGAAAACCCTGTTTTTGAAAATGAAGTT TTAGGATATTGGGTTGGTTATAATGATGTAAGTAACATAAAGAATTCTATTATCTATATTTATA AATATAATGGGGAAGTTTATGGCCGAATTTTAACTATAATAAAAGATGGCAAAAAGTATGATG CTAAAAATCCTTCAGGAGATACTGTAGTTGGGTTTGAAAATCTTGCAATAGAGGGTCTTGATTT TATGTGGGGTCTTAAGTATTCTTCTTCTTCTAAAAAGTGGGATAGGGGCAAAATAATAGATCCT AAAAACGGTAAAATTTATAATTCTGAGATGCGTGTTGATAGTAAAACCGGAAATCTTATTACCA AGGGGAAAGTTTGGATTTTTGGTAGAAGTAAAATTTGGACAAGAGCTAAAGATGATGAAATAC CAAAATTAGATTTGCATAATCTTGTTCCAGCGCCCCCTGTGAAAAAATAA f82.nt (SEQ ID NO:112) GAAGATTCAAATGAAAAGGACATTGTTAGCAAGGATGAAAACCCTGTTTTTGAAAATGAAGTT TTAGGATATTGGGTTGGTTATAATGATGTAAGTAACATAAAGAATTCTATTATCTATATTTATA AATATAATGGGGAAGTTTATGGCCGAATTTTAACTATAATAAAAGATGGCAAAAAGTATGATG CTAAAAATCCTTCAGGAGATACTGTAGTTGGGTTTGAAAATCTTGCAATAGAGGGTCTTGATTT TATGTGGGGTCTTAAGTATTCTTCTTCTTCTAAAAAGTGGGATAGGGGCAAAATAATAGATCCT AAAAACGGTAAAATTTATAATTCTGAGATGCGTGTTGATAGTAAAACCGGAAATCTTATTACCA AGGGGAAAGTTTGGATTTTTGGTAGAAGTAAAATTTGGACAAGAGCTAAAGATGATGAAATAC CAAAATTAGATTTGCATAATCTTGTTCCAGCGCCCCCTGTGAAAAAATAA f86.aa (SEQ ID NO:113) MNKLMLMLITFATSLLAQTNKASTGLKTDQSTNNSLSESVKLKEIADIYPTNTNFLTGIGIV AGLAGKGDSIKQKDLIIKILEENNIINEIGSNNIESKNIALVNVSLQVKGNTIKGSKHKACVASILDSKD LTNGILLKTNLKNKEGEIIAIASGITQPNNKLKGSGYTIDSVIINENQNINHSYNIILKKGNYTLINRIHK ILTSKKINNKIKSDSTIEIEAKNISLLEEIENIKIETNPKILIDKKNGIILASENAKIGTFTFSIEKDNQNIFL SKNNKTTIQVNSMKLNEFILKNSNNLSNKELIQIIQAAQKINKLNGELILEEIDGNQN t86.aa (SEQ ID NO:114) LKTDQSFNNSLSESVKLKEIADIYPTNTNFLTGIGIVAGLAGKGDSIKQKDLIIKILEENNIINEIGSNNI ESKNIALVNVSLQVKGNTIKGSKHKACVASILDSKDLTNGILLKTNLKNKEGEIIAIASGITQPNNKLK GSGYTIDSVIINENQNINHSYNIILKKGNYTLINRIHKILTSKKINNKIKSDSTIEIEAKNISLLEEIENIKI ETNPKILIDKKNGIILASENAKIGTFTFSIEKDNQNIFLSKNNKTTIQVNSMKLNEFILKNSNNLSNKEL IQIIQAAQKINKLNGELILEEIDGNQN f86.nt (SEQ ID NO:115) ATGAACAAACTAATGTTGATGTTAATTACATTTGCAACGAGTCTATTAGCCCAAACAAACAAAG CTTCAACAGGACTAAAAACAGATCAATCATTTAACAATAGCCTATCTGAAAGCGTAAAATTAAA AGAAATTGCGGATATTTATCCCACAAATACAAATTTTTTAACAGGTATTGGAATAGTAGCGGGA CTTGCTGGAAAAGGAGACTCTATAAAACAAAAAGACCTTATAATTAAAATTTTAGAAGAAAAC AATATAATAAATGAAATAGGCTCTAATAACATAGAAAGTAAAAATATTGCACTAGTAAATGTC AGTCTCCAAGTAAAAGGTAATACAATCAAAGGTTCAAAACATAAAGCTTGCGTTGCATCAATAC TGGACTCAAAAGATTTAACAAATGGAATACTTTTAAAAACAAATCTTAAAAATAAAGAGGGGG AAATAATAGCAATTGCATCAGGAATTACACAGCCCAATAATAAATTAAAAGGATCTGGATATA CTATAGATAGTGTAATAATAAATGAGAATCAAAATATTAACCACAGTTATAATATAATTCTTAA AAAAGGAAATTATACATTAATAAATAGAATTCATAAAATATTAACCTCTAAAAAAATCAACAAC AAAATTAAATCAGACAGCACAATAGAAATAGAAGCAAAAAACATAAGCCTATTAGAAGAGATT GAAAATATTAAAATAGAAACCAACCCCAAGATATTAATAGACAAAAAAAATGGTATTATTTTA GCAAGTGAAAATGCAAAAATAGGAACTTTTACATTTTCCATTGAAAAAGACAATCAAAACATTT TTTTAAGTAAAAATAACAAAACAACAATTCAAGTAAACTCAATGAAATTAAATGAATTTATATT AAAAAATTCCAACAATCTTAGCAATAAAGAATTAATTCAAATAATTCAAGCTGCGCAAAAAATT AATAAATTAAATGGGGAACTTATCTTGGAGGAAATTGATGGAAACCAAAATTAA t86.nt (SEQ ID NO:116) CTAAAAACAGATCAATCATTTAACAATAGCCTATCTGAAAGCGTAAAATTAAAAGAAATTGCG GATATTTATCCCACAAATACAAATTTTTTAACAGGTATTGGAATAGTAGCGGGACTTGCTGGAA AAGGAGACTCTATAAAACAAAAAGACCTTATAATTAAAATTTTAGAAGAAAACAATATAATAA ATGAAATAGGCTCTAATAACATAGAAAGTAAAAATATTGCACTAGTAAATGTCAGTCTCCAAGT AAAAGGTAATACAATCAAAGGTTCAAAACATAAAGCTTGCGTTGCATCAATACTGGACTCAAA AGATTTAACAAATGGAATACTTTTAAAAACAAATCTTAAAAATAAAGAGGGGGAAATAATAGC AATTGCATCAGGAATTACACAGCCCAATAATAAATTAAAAGGATCTGGATATACTATAGATAGT GTAATAATAAATGAGAATCAAAATATTAACCACAGTTATAATATAATTCTTAAAAAAGGAAATT ATACATTAATAAATAGAATTCATAAAATATTAACCTCTAAAAAAATCAACAACAAAATTAAATC AGACAGCACAATAGAAATAGAAGCAAAAAACATAAGCCTATTAGAAGAGATTGAAAATATTAA AATAGAAACCAACCCCAAGATATTAATAGACAAAAAAAATGGTATTATTTTAGCAAGTGAAAA TGCAAAAATAGGAACTTTTACATTTTCCATTGAAAAAGACAATCAAAACATTTTTTTAAGTAAA AATAACAAAACAACAATTCAAGTAAACTCAATGAAATTAAATGAATTTATATTAAAAAATTCCA ACAATCTTAGCAATAAAGAATTAATTCAAATAATTCAAGCTGCGCAAAAAATTAATAAATTAAA TGGGGAACTTATCTTGGAGGAAATTGATGGAAACCAAAATTAA f90.aa (SEQ ID NO:117) MCPITFTIPFFLAIFFAFSSSFVTDSSVSLLSRNTSLFSTLTPISLPIISGTLPAIVTLSKKYLSISLSFSKMIF IKSLFEVIKLPIWLFIIFASGYFLNAFSIFLCISSFLSFMFI t90.aa (SEQ ID NO:118) SSFVTDSSVSLLSRNTSLFSTLTPISLPIISGTLPAIVTLSKKYLSISLSFSKMIFIKSLFEVIKLPIWLFIIFA SGYFLNAFSIFLCISSFLSFMFI f90.nt (SEQ ID NO:119) ATGTGTCCTATTACTTTTACCATTCCATTTTTTCTAGCAATATTTTTTGCTTTTTCAAGCTCCTTT GTTACGGACTCTTCTGTGTCTTTGCTATCAAGAAATACGTCTCTTTTTTCTACTTTAACTCCAATT TCTTTGCCTATTATTTCTGGTACGCTTCCTGCAATAGTTACGCTGTCGAAAAAATATCTGTCAAT CTCTTTAAGCTTTTCTAAAATGATTTTCATCAAATCTTTATTTGAAGTGATTAAACTTCCCATAT GGTTATTCATTATTTTTGCATCAGGATACTTTTTAAATGCTTTTTCGATTTTTTTGTGTATTTCTT CTTTTTTATCTTTTATGTTTATATGA t90.nt (SEQ ID NO:120) AGCTCCTTTGTTACGGACTCTTCTGTGTCTTTGCTATCAAGAAATACGTCTTTTTTCTACTTTA ACTCCAATTTCTTTGCCTATTATTTCTGGTACGCTTCCTGCAATAGTTACGCTGTCGAAAAAATA TCTGTCAATCTCTTTAAGCTTTTCTAAAATGATTTTCATCAAATCTTTATTTGAAGTGATTAAAC TTCCCATATGGTTATTCATTATTTTTGCATCAGGATACTTTTTAAATGCTTTTTCGATTTTTTTGT GTATTTCTTCTTTTTTATCTTTTATGTTTATATGA f469.aa (SEQ ID NO:121) MANVALSSGFISQKIFGIIIIMVFLPTIIATPIINFLFKINKSGLKKELPIDQNTHICVSFEYDNLAKILIWD FKNELRKEGFFTQQIKNDSSQYINARKNNISFSIKREGSKITFECPNNHLIIIQDLFRETILNLEKITKEV ETVSLRAKKLDYSINYDKILSNINLNKRIKKENIILELKSSNKADVIRELLSVINIEIDKERIFQDLMERE KLITTALKEGFAIPHLKTNLISKIHIAIGISHEGIDFNALDKNLSHVFILILCPAKDYVSYPRILASVVGK VDLYKKEILNAKTDKEIYNIIVS t469.aa (SEQ ID NO:122) VFLPTIIATPIINFLFKINKSGLKKELPIDQNTHICVSFEYDNLAKILIWDFKNELRKEGFFTQQIKNDSS QYINARKNNISFSIKREGSKITFECPNNHLIIIQDLFRETILNLEKITKEVETVSLRAKKLDYSINYDKIL SNINLNKRIKKENIILELKSSNKADVIRELLSVINIEIDKERIFQDLMEREKLITTALKEGFAIPHLKTNLI SKIHLAIGISHEGIDFNALDKNLSHVFILILCPAKDYVSYPRILASVVGKVDLYKKEILNAKTDKEIYNII VS f469.nt (SEQ ID NO:123) ATGGCAAATGTAGCATTATCTTCAGGATTTATTAGCCAAAAAATATTTGGAATCATAATAATAA TGGTGTTTTTGCCAACAATCATTGCAACACCCATAATAAACTTTTTATTTAAAATAAATAAAAG TGGACTTAAAAAAGAACTCCCAATAGATCAAAATACACACATATGCGTATCATTTGAATATGAT AATTTAGCCAAAATTCTTATATGGGACTTTAAAAATGAGTTAAGAAAAGAAGGATTTTTTACAC AACAAATTAAAAATGATTCTTCACAATATATTAATGCAAGAAAAAACAATATATCCTTCTCAAT AAAACGAGAAGGTAGCAAAATCACATTTGAATGCCCAAATAATCATTTAATTATAATACAAGAT CTTTTTAGAGAAACAATCTTAAACCTAGAAAAAATAACCAAAGAAGTTGAAACAGTCTCTTTAA GAGCAAAAAAACTAGATTACTCAATAAATTACGATAAAATCCTTAGTAATATCAACCTAAATAA AAGAATAAAAAAGGAAAACATTATTCTAGAATTAAAATCAAGCAATAAGGCTGATGTAATAAG AGAGCTTCTAAGCGTAATAAACATTGAAATTGATAAAGAAAGAATATTCCAAGATTTAATGGA AAGAGAAAAGTTAATTACTACTGCACTAAAAGAAGGCTTTGCCATTCCCCATTTAAAAACAAAT TTAATATCAAAAATACATATTGCAATAGGAATAAGCCATGAGGGAATTGACTTTAATGCTCTTG ACAAGAACTTAAGTCATGTTTTTATATTAATACTGTGCCCAGCAAAAGATTACGTTAGCTACCC TAGAATTTTAGCATCTGTTGTGGGCAAAGTTGATCTGTACAAAAAAGAAATTTTAAATGCAAAA ACAGATAAAGAAATTTATAATATAATAGTGAGCTAA t469.nt (SEQ ID NO:124) TTTTTGCCAACAATCATTGCAACACCCATAATAAACTTTTTATTTAAAATAAATAAAAGTGGAC TTAAAAAAGAACTCCCAATAGATCAAAATACACACATATGCGTATCATTTGAATATGATAATTT AGCCAAAATTCTTATATGGGACTTTAAAAATGAGTTAAGAAAAGAAGGATTTTTTACACAACAA ATTAAAAATGATTCTTCACAATATATTAATGCAAGAAAAAACAATATATCCTTCTCAATAAAAC GAGAAGGTAGCAAAATCACATTTGAATGCCCAAATAATCATTTAATTATAATACAAGATCTTTT TAGAGAAACAATCTTAAACCTAGAAAAAATAACCAAAGAAGTTGAAACAGTCTCTTTAAGAGC AAAAAAACTAGATTACTCAATAAATTACGATAAAATCCTTAGTAATATCAACCTAAATAAAAGA ATAAAAAAGGAAAACATTATTCTAGAATTAAAATCAAGCAATAAGGCTGATGTAATAAGAGAG CTTCTAAGCGTAATAAACATTGAAATTGATAAAGAAAGAATATTCCAAGATTTAATGGAAAGA GAAAAGTTAATTACTACTGCACTAAAAGAAGGCTTTGCCATTCCCCATTTAAAAACAAATTTAA TATCAAAAATACATATTGCAATAGGAATAAGCCATGAGGGAATTGACTTTAATGCTCTTGACAA GAACTTAAGTCATGTTTTTATATTAATACTGTGCCCAGCAAAAGATTACGTTAGCTACCCTAGA ATTTTAGCATCTGTTGTGGGCAAAGTTGATCTGTACAAAAAAGAAATTTTAAATGCAAAAACAG ATAAAGAAATTTATAATATAATAGTGAGCTAA f477.aa (SEQ ID NO:125) MEKPQGVSIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVEGLLEYGEKYYSQHKKPLF SSHMLDLSEEPIKENIEISKKFLERMAKIEMFLEIELGITGGEEDGVDNSDRALHELFSTPEDIYYGYSE LLKVSPNFQIAAAFGNVHGVYKPGNVKLTPKVLKDGQDYVISKTGVNMAKPVSYVFHGGSGSTIDE INEALSYGVVKMNIDTDTQWAAWEGVLNYYKKNESRLQGQLGDGKDIDIPNKKFYDPRVWLREA EVSMKDRVKIACKNLNNINRN t477.aa (SEQ ID NO:126) MHVHLMAEHYGVPVVLHTDHCAKNLLPWVEGLLEYGEKYYSQHKKPLFSSHMLDLSEEPIKENIEI SKKFLERMAKIEMFLEIELGITGGEEDGVDNSDRALHELFSTPEDIYYGYSELLKVSPNFQIAAAFGN VHGVYKPGNVKLTPKVLKDGQDYVISKTGVNMAKPVSYVFHGGSGSTIDEINEALSYGVVKMNID TDTQWAAWEGVLNYYKKNESRLQGQLGDGKDIDIPNKKFYDPRVWLREAEVSMKDRVKIACKNL NNINRN f477.nt (SEQ ID NO:127) ATGGAAAAACCACAAGGAGTTTCAATAGTTGGAGCTATTTCTGGTGCTATGCATGTTCATTTAA TGGCAGAGCATTATGGTGTTCCTGTTGTTCTTCATACTGATCACTGTGCTAAAAATTTGCTTCCT TGGGTTGAAGGCCTTTTAGAATATGGAGAGAAATACTATAGTCAGCACAAAAAACCATTATTTT CTTCACATATGTTAGATTTATCAGAAGAACCTATTAAAGAAAATATTGAAATTTCTAAAAAATT CTTAGAAAGAATGGCAAAAATTGAAATGTTTTTGGAAATAGAGCTTGGAATTACGGGTGGGGA AGAGGATGGAGTTGACAATTCAGATAGAGCTTTGCATGAACTATTTTCTACTCCTGAGGATATT TATTATGGATATTCAGAACTTTTAAAAGTTAGCCCAAATTTTCAGATTGCAGCAGCTTTTGGAA ATGTTCATGGGGTATATAAACCGGGGAATGTTAAGCTTACTCCAAAAGTTTTAAAAGATGGTCA AGATTATGTCATATCAAAAACAGGAGTAAATATGGCTAAGCCAGTTTCTTATGTTTTTCATGGA GGGTCTGGATCTACAATTGATGAGATTAATGAGGCGCTTTCTTATGGCGTTGTAAAGATGAATA TTGACACAGATACACAGTGGGCTGCCTGGGAGGGTGTTTTAAATTATTACAAAAAAAATGAAA GTCGTTTGCAAGGTCAATTAGGAGATGGCAAGGATATTGATATTCCAAATAAGAAATTTTATGA TCCAAGGGTTTGGTTAAGAGAAGCTGAAGTTTCTATGAAAGACCGTGTGAAGATTGCATGCAA AAATCTTAATAATATTAATAGAAATTAA t477.nt (SEQ ID NO:128) ATGCATGTTCATTTAATGGCAGAGCATTATGGTGTTCCTGTTGTTCTTCATACTGATCACTGTGC TAAAAATTTGCTTCCTTGGGTTGAAGGCCTTTTAGAATATGGAGAGAAATACTATAGTCAGCAC AAAAAACCATTATTTTCTTCACATATGTTAGATTTATCAGAAGAACCTATTAAAGAAAATATTG AAATTTCTAAAAAATTCTTAGAAAGAATGGCAAAAATTGAAATGTTTTTGGAAATAGAGCTTGG AATTACGGGTGGGGAAGAGGATGGAGTTGACAATTCAGATAGAGCTTTGCATGAACTATTTTCT ACTCCTGAGGATATTTATTATGGATATTCAGAACTTTTAAAAGTTAGCCCAAATTTTCAGATTGC AGCAGCTTTTGGAAATGTTCATGGGGTATATAAACCGGGGAATGTTAAGTTACTCCAAAAGTT TTAAAAGATGGTCAAGATTATGTCATATCAAAAACAGGAGTAAATATGGCTAAGCCAGTTTCTT ATGTTTTTCATGGAGGGTCTGGATCTACAATTGATGAGATTAATGAGGCGCTTTCTTATGGCGT TGTAAAGATGAATATTGACACAGATACACAGTGGGCTGCCTGGGAGGGTGTTTTAAATTATTAC AAAAAAAATGAAAGTCGTTTGCAAGGTCAATTAGGAGATGGCAAGGATATTGATATTCCAAAT AAGAAATTTTATGATCCAAGGGTTTGGTTAAGAGAAGCTGAAGTTTCTATGAAAGACCGTGTGA AGATTGCATGCAAAAATCTTAATAATATTAATAGAAATTAA f488.aa (SEQ ID NO:129) MPSSFPFLLVNGSSGIAVGMATNMAPHNLREICDAIVYMLDNENASIFDLLKIVKGPDFPTFGEIVYN DNLIKAYKTGKGSVVIRARYHIEERAEDRNAIIVTEIPYTVNKSALLMKVALLAKEEKLEGLLDIRDE SDREGIRIVLEVKRGFDPHVIMNLLYEYTEFKKHFSINNLALVNGIPKQLNLEELLFEFIEHRKNIIERR IETDLRKAKEKAHVLEGLNIALNNIDEVIKIIKSSKLAKDARERLVSNFGLSEIQANSVLDMRLQKLT ALEIFKLEEELNILLSLIKDYEDILLNPVRIINIIREETINLGLKFGDERRTKIIYDEEVLKTSMSDLMQK ENIVVMLTKKGFLKRLSQNEYKLQGTGGKGLSSFDLNDGDEIVIALCVNTHDYLFMISNEGKLYLIN AYEIKDSSRASKGQNISELINLGDQEEILTIKNSKDLTDDAYLLLTTASGKIARFESTDFKAVKSRGVI VIKLNDKDFVTSAEIVFKDEKVICLSKKGSAFIFNSRDVRLTNRGTQGVCGMKLKEGDLFVKVLSVK ENPYLLIVSENGYGKRLNMSKISELKRGATGYTSYKKSDKKAGSVVDAIAVSEDDEILLVSKRSKAL RTVAGKVSEQGKDARGIQVLFLDNDSLVSVSKFIK t488.aa (SEQ ID NO:130) MATNMAPHNLREICDAIVYMLDNENASIFDLLKIVKGPDFPTFGEIVYNDNLIKAYKTGKGSVVIRA RYHIEERAEDRNAIIVTEIPYTVNKSALLMKVALLAKEEKLEGLLDIRDESDREGIRIVLEVKRGFDPH VIMNLLYEYTEFKKHFSINNLALVNGIPKQLNLEELLFEFIEHRKNIIERRIEFDLRKAKEKAHVLEGL NIALNNIDEVIKIIKSSKLAKDARERLVSNFGLSEIQANSVLDMRLQKLTALEIFKLEEELNILLSLIKD YEDILLNPVRIINIIREETINLGLKFGDERRTKIIYDEEVLKTSMSDLMQKENIVVMLTKKGFLKRLSQ NEYKLQGTGGKGLSSFDLNDGDEIVIALCVNTHDYLFMISNEGKLYLINAYEIKDSSRASKGQNISEL INLGDQEEILTIKNSKDLTDDAYLLLTTASGKIARFESTDFKAVKSRGVIVIKLNDKDFVTSAEIVFKD EKVICLSKKGSAFIFNSRDVRLTNRGTQGVCGMKLKEGDLFVKVLSVKENPYLLIVSENGYGKRLN MSKISELKRGATGYTSYKKSDKKAGSVVDAIAVSEDDEILLVSKRSKALRTVAGKVSEQGKDARGI QVLFLDNDSLVSVSKFIK f488.nt (SEQ ID NO:131) ATGCCGTCATCATTTCCATTTCTTTTGGTAAATGGCTCTAGTGGAATTGCTGTTGGAATGGCTAC TAATATGGCACCTCATAATTTAAGAGAAATTTGTGATGCCATTGTTTACATGCTAGATAATGAG AATGCTTCTATATTTGATTTGCTTAAAATAGTTAAAGGGCCTGATTTCCCAACTTTTGGAGAGAT TGTTTATAATGATAATTTAATTAAAGCATACAAAACTGGCAAGGGAAGTGTTGTTATTAGGGCA AGATATCATATTGAAGAAAGAGCAGAAGATAGAAATGCTATAATTGTTACAGAAATACCTTAT ACGGTAAATAAATCTGCACTTCTTATGAAAGTTGCGCTTTTAGCAAAAGAAGAAAAGCTAGAA GGACTTTTAGATATAAGAGATGAATCTGATCGAGAAGGTATTAGGATAGTTCTTGAAGTTAAAA GAGGATTTGATCCTCATGTTATTATGAATTTGCTTTATGAATATACTGAATTTAAAAAGCATTTT AGTATAAATAATTTAGCCCTTGTTAATGGTATTCCCAAACAGTTAAATTTAGAAGAATTGTTAT TTGAATTTATTGAGCATAGAAAAAATATTATCGAAAGACGTATTGAATTTGACTTGAGAAAGGC AAAAGAGAAAGCACATGTTCTTGAGGGATTAAATATTGCTTTAAATAATATAGATGAGGTTATT AAGATTATTAAATCATCTAAATTAGCAAAAGATGCAAGGGAGAGGCTTGTTTCGAATTTTGGTC TTTCAGAGATTCAGGCCAATTCAGTTCTTGATATGAGGTTACAAAAACTTACAGCCCTTGAGAT TTTTAAGCTTGAAGAGGAGCTTAATATACTGTTAAGCTTAATAAAAGATTATGAAGATATTCTC TTGAATCCAGTAAGGATTATTAATATTATAAGAGAAGAAACTATTAATTTAGGTTTGAAATTTG GCGATGAACGTCGAACTAAAATAATTTATGATGAGGAGGTTTTAAAAACTAGTATGTCGGATTT AATGCAAAAAGAAAATATTGTTGTTATGCTTACAAAGAAAGGTTTCCTTAAAAGACTTTCACAA AATGAGTATAAATTGCAAGGTACGGGAGGAAAAGGACTAAGTTCGTTTGATCTAAATGATGGA GATGAGATTGTTATTGCTTTGTGTGTCAATACTCATGATTATTTATTTATGATTTCAAATGAAGG AAAGCTTTATTTAATCAATGCTTATGAAATAAAAGATTCTTCAAGAGCTTCAAAAGGTCAGAAT ATTAGTGAGCTTATTAATTTAGGAGATCAAGAAGAAATATTAACTATTAAGAATAGTAAAGATT TAACTGATGATGCTTATTTATTGCTTACAACTGCAAGTGGAAAGATAGCTAGATTCGAATCTAC AGATTTTAAAGCAGTAAAGTCACGAGGTGTTATTGTTATTAAACTGAATGATAAAGATTTTGTT ACAAGTGCAGAGATTGTTTTTAAGGATGAAAAAGTAATTTGTCTTTCTAAAAAGGGTAGTGCAT TTATATTTAATTCAAGGGATGTTAGGCTTACTAATAGAGGTACCCAAGGTGTTTGTGGAATGAA ATTAAAAGAAGGTGATTTGTTTGTTAAAGTTTTATCGGTTAAAGAAAATCCTTATCTTTTGATTG TTTCTGAAAATGGGTATGGAAAAAGGTTAAACATGTCTAAAATATCTGAGCTTAAAAGAGGAG CCACTGGTTATACTAGTTATAAAAAATCTGATAAAAAAGCGGGTAGTGTTGTTGATGCTATAGC AGTTTCAGAGGATGATGAAATCTTGCTTGTAAGTAAACGTTCAAAAGCTTTAAGAACAGTAGCT GGAAAAGTATCTGAACAAGGCAAAGATGCTAGAGGAATTCAAGTATTATTTCTTGATAATGAC AGCTTGGTTTCTGTTTCAAAATTTATTAAATAA t488.nt (SEQ ID NO:132) ATGGCTACTAATATGGCACCTCATAATTTAAGAGAAATTTGTGATGCCATTGTTTACATGCTAG ATAATGAGAATGCTTCTATATTTGATTTGCTTAAAATAGTTAAAGGGCCTGATTTCCCAACTTTT GGAGAGATTGTTTATAATGATAATTTAATTAAAGCATACAAAACTGGCAAGGGAAGTGTTGTTA TTAGGGCAAGATATCATATTGAAGAAAGAGCAGAAGATAGAAATGCTATAATTGTTACAGAAA TACCTTATACGGTAAATAAATCTGCACTTCTTATGAAAGTTGCGCTTTTAGCAAAAGAAGAAAA GCTAGAAGGACTTTTAGATATAAGAGATGAATCTGATCGAGAAGGTATTAGGATAGTTCTTGA AGTTAAAAGAGGATTTGATCCTCATGTTATTATGAATTTGCTTTATGAATATACTGAATTTAAA AAGCATTTTAGTATAAATAATTTAGCCCTTGTTAATGGTATTCCCAAACAGTTAAATTTAGAAG AATTGTTATTTGAATTTATTGAGCATAGAAAAAATATTATCGAAAGACGTATTGAATTTGACTT GAGAAAGGCAAAAGAGAAAGCACATGTTCTTGAGGGATTAAATATTGCTTTAAATAATATAGA TGAGGTTATTAAGATTATTAAATCATCTAAATTAGCAAAAGATGCAAGGGAGAGGCTTGTTTCG AATTTTGGTCTTTCAGAGATTCAGGCCAATTCAGTTCTTGATATGAGGTTACAAAAACTTACAG CCCTTGAGATTTTTAAGCTTGAAGAGGAGCTTAATATACTGTTAAGCTTAATAAAAGATTATGA AGATATTCTCTTGAATCCAGTAAGGATTATTAATATTATAAGAGAAGAAACTATTAATTTAGGT TTGAAATTTGGCGATGAACGTCGAACTAAAATAATTTATGATGAGGAGGTTTTAAAAACTAGTA TGTCGGATTTAATGCAAAAAGAAAATATTGTTGTTATGCTTACAAAGAAAGGTTTCCTTAAAAG ACTTTCACAAAATGAGTATAAATTGCAAGGTACGGGAGGAAAAGGACTAAGTTCGTTTGATCT AAATGATGGAGATGAGATTGTTATTGCTTTGTGTGTCAATACTCATGATTATTTATTTATGATTT CAAATGAAGGAAAGCTTTATTTAATCAATGCTTATGAAATAAAAGATTCTTCAAGAGCTTCAAA AGGTCAGAATATTAGTGAGCTTATTAATTTAGGAGATCAAGAAGAAATATTAACTATTAAGAAT AGTAAAGATTTAACTGATGATGCTTATTTATTGCTTACAACTGCAAGTGGAAAGATAGCTAGAT TCGAATCTACAGATTTTAAAGCAGTAAAGTCACGAGGTGTTATTGTTATTAAACTGAATGATAA AGATTTTGTTACAAGTGCAGAGATTGTTTTTAAGGATGAAAAAGTAATTTGTCTTTCTAAAAAG GGTAGTGCATTTATATTTAATTCAAGGGATGTTAGGCTTACTAATAGAGGTACCCAAGGTGTTT GTGGAATGAAATTAAAAGAAGGTGATTTGTTTGTTAAAGTTTTATCGGTTAAAGAAAATCCTTA TCTTTTGATTGTTTCTGAAAATGGGTATGGAAAAAGGTTAAACATGTCTAAAATATCTGAGCTT AAAAGAGGAGCCACTGGTTATACTAGTTATAAAAAATCTGATAAAAAAGCGGGTAGTGTTGTT GATGCTATAGCAGTTTCAGAGGATGATGAAATCTTGCTTGTAAGTAAACGTTCAAAAGCTTTAA GAACAGTAGCTGGAAAAGTATCTGAACAAGGCAAAGATGCTAGAGGAATTCAAGTATTATTTC TTGATAATGACAGCTTGGTTTCTGTTTCAAAATTTATTAAATAA f494.aa (SEQ ID NO: 133) MFALIRKIFMIYFLCITLAGFAMIFIDSKFTEQPNVKENQSKINQHTIEPNLIMFTSSIGGFLGVYVGIWI FNYDKSNFYLNWGNLIILIYNIALIITVYSKSHS t494.aa (SEQ ID NO:134) MIFIDSKFTEQPNVKENQSKINQHTIEPNLIMFTSSIGGFLGVYVGIWIFNYDKSNFYLNWGNLIILIYN IALIITVYSKSHS f494.nt (SEQ ID NO:135) ATGTTTGCATTAATTAGAAAAATATTTATGATCTATTTTTTATGCATTACTCTTGCAGGTTTTGC CATGATTTTTATTGACAGCAAATTTACCGAACAGCCTAATGTTAAAGAAAATCAAAGCAAAATT AATCAACATACAATTGAACCCAATTTAATCATGTTTACATCTTCTATAGGAGGATTTTTAGGTGT TTATGTTGGAATTTGGATCTTTAACTATGACAAAAGCAATTTTTACCTAAATTGGGGAAATTTA ATAATATTAATATACAACATAGCCCTAATTATCACTGTATACTCAAAATCACATAGTTAG t494.nt (SEQ ID NO:136) ATGATTTTTATTGACAGCAAATTTACCGAACAGCCTAATGTTAAAGAAAATCAAAGCAAAATTA ATCAACATACAATTGAACCCAATTTAATCATGTTTACATCTTCTATAGGAGGATTTTTAGGTGTT TATGTTGGAATTTGGATCTTTAACTATGACAAAAGCAATTTTTACCTAAATTGGGGAAATTTAA TAATATTAATATACAACATAGCCCTAATTATCACTGTATACTCAAAATCACATAGTTAG f516.aa (SEQ ID NO:137) MKKTPNTCIFLTLLIISNLNALANEEGNTNEKNDQPKQISNFFSPERGFIYSTGIGIGVGFFLNSNIKHLI FRPYYTFSNNTFDFLIVAMILTRESLNIPKKMQYFKSYIGGGINWHIANLIKKTKYFSATIGIGGRFYL STNFIEDIRFYEKLPYVIEPYMFIEISSKKAIPLMGLDFKIDFLFLDTFNISFNFTIRYNFKDKNEMET t516.aa (SEQ ID NO:138) NEEGNTNEKNDQPKQISNFFSPERGFIYSTGIGIGVGFFLNSNIKHLIFRPYYTFSNNTFDFLIVAMILT RESLNIPKKMQYFKSYIGGGINWHIANLIKKTKYFSATIGIGGRFYLSTNFIEDIRFYEKLPYVIEPYMF IEISSKKAIPLMGLDFKIDFLFLDTFNISFNFTIRYNFKDKNEMET f516.nt (SEQ ID NO:139) ATGAAAAAAACTCCAAACACTTGTATTTTCTTAACATTGCTTATCATTTCCAATTTAAATGCACT TGCAAATGAAGAAGGCAATACTAATGAAAAAAATGATCAACCCAAACAAATCTCTAATTTTTTT AGCCCAGAAAGAGGGTTCATATATTCAACAGGAATTGGGATTGGAGTTGGATTTTTTCTAAATT CAAATATTAAACACCTTATCTTTAGACCTTATTATACATTCTCTAATAATACTTTTGATTTTTTA ATCGTTGCTATGATATTAACAAGGGAAAGCCTTAATATCCCCAAAAAAATGCAATACTTTAAAT CTTATATTGGAGGAGGAATAAACTGGCACATTGCAAACTTAATTAAAAAAACAAAATATTTTTC CGCCACCATTGGCATAGGTGGTCGTTTTTACCTATCTACAAACTTTATAGAAGACATTCGATTTT ACGAAAAATTGCCTTATGTAATAGAGCCTTATATGTTTATTGAAATTTCTTCTAAAAAGGCAAT TCCTTTAATGGGGTTAGACTTTAAAATTGATTTTTTATTTTTAGATACATTAACATTTCTTTTAA TTTTACTATTAGATATAATTTTAAGGACAAAAACGAGATGGAAACATGA t516.nt (SEQ ID NO:140) AATGAAGAAGGCAATACTAATGAAAAAAATGATCAACCCAAACAAATCTCTAATTTTTTTAGCC CAGAAAGAGGGTTCATATATTCAACAGGAATTGGGATTGGAGTTGGATTTTTTCTAAATTCAAA TATTAAACACCTTATCTTTAGACCTTATTATACATTCTCTAATAATACTTTTGATTTTTTAATCGT TGCTATGATATTAACAAGGGAAAGCCTTAATATCCCCAAAAAAATGCAATACTTTAAATCTTAT ATTGGAGGAGGAATAAACTGGCACATTGCAAACTTAATTAAAAAAACAAAATATTTTTCCGCCA CCATTGGCATAGGTGGTCGTTTTTACCTATCTACAAACTTTATAGAAGACATTCGATTTTACGAA AAATTGCCTTATGTAATAGAGCCTTATATGTTTATTGAAATTTCTTCTAAAAAGGCAATTCCTTT AATGGGGTTAGACTTTAAAATTGATTTTTTATTTTTAGATACATTTAACATTTCTTTTAATTTTA CTATTAGATATAATTTTAAGGACAAAAACGAGATGGAAACATGA f517.aa (SEQ ID NO:141) MIPVVASGGILIALSIAFVGIGPDGPNFAEHPFYKQIADIGSIAFGMMLPVLAGFIAMAIADKPGLTPG LVGGVMSGNVKAGFLGAIFAGFLAGYVARFLARRSVPEWLRPVMPIFVIPLISTIIVGFFMLYFGVYI GKFMGVLESGLKSLQSNSETFGVLGKIFLGLVLGSMITVDMGGPFNKVAFLFGVGLIPQVPEIMGMV AAAIPVPPMAMGLATFLAPKLFENEEKESGKIAFLISFIGISEGAIPFAASDPGRVIPSIVVGGAVSSIIA AFLGVANHAPHGGPIVLPVIDNKFGFIIAIAVGVAVATALVIFLKSLKLKESE t517.aa (SEQ ID NO:142) DKPGLTPGLVGGVMSGNVKAGFLGAIFAGFLAGYVARFLARRSVPEWLRPVMPIFVIPLISTIIVGFF MLYFGVYIGKFMGVLESGLKSLQSNSETFGVLGKIFLGLVLGSMITVDMGGPFNKVAFLFGVGLIPQ VPEIMGMVAAAIPVPPMAMGLATFLAPKLFENEEKESGKIAFLISFIGISEGAIPFAASDPGRVIPSIVV GGAVSSIIAAFLGVANHAPHGGPIVLPVIDNKFGFIIAIAVGVAVATALVIFLKSLKLKESE f517.nt (SEQ ID NO:143) ATGATTCCTGTTGTTGCAAGTGGAGGAATTTTAATTGCTCTTAGCATTGCTTTTGTTGGGATTGG ACCTGATGGGCCTAATTTTGCTGAGCATCCATTTTATAAGCAGATTGCAGATATTGGTTCTATA GCTTTTGGGATGATGTTGCCCGTGCTTGCTGGTTTTATTGCAATGGCAATTGCTGATAAGCCTG GTCTTACCCCCGGTCTTGTTGGTGGAGTAATGTCTGGGAATGTAAAAGCAGGTTTCTTGGGCGC AATATTTGCGGGCTTTCTTGCAGGTTATGTTGCAAGGTTTTTAGCAAGAAGATCTGTTCCTGAG TGGTTAAGACCTGTAATGCCTATATTTGTAATTCCGCTAATAAGCACCATTATTGTCGGCTTTTT TATGCTGTATTTTGGTGTTTATATTGGAAAATTTATGGGGGTGCTTGAGAGTGGGCTTAAATCT TTACAGAGTAATTCGGAAACTTTTGGCGTGTTGGGTAAAATTTTCTTAGGCTTAGTACTAGGTT CAATGATTACTGTTGATATGGGCGGACCTTTTAATAAAGTGGCATTTCTTTTTGGTGTAGGGCT AATTCCTCAAGTGCCAGAAATAATGGGAATGGTAGCAGCAGCAATTCCTGTTCCTCCTATGGCT ATGGGGCTTGCAACCTTTTTAGCACCTAAATTGTTTGAAAATGAAGAAAAAGAATCTGGTAAAA TAGCCTTTTTAATTTCATTTATTGGTATTAGCGAAGGAGCTATTCCTTTTGCTGCTAGTGATCCC GGACGGGTAATCCCTTCGATAGTGGTAGGGGGAGCTGTATCAAGCATTATTGCCGCTTTTTTAG GCGTTGCTAATCATGCTCCACACGGAGGACCAATAGTACTTCCTGTTATTGATAATAAATTTGG GTTTATTATTGCAATTGCTGTTGGAGTTGCGGTTGCAACAGCTTTGGTAATTTTTTTGAAATCTT TAAAATTAAAGGAATCTGAATGA t517.nt (SEQ ID NO:144) GATAAGCCTGGTCTTACCCCCGGTCTTGTTGGTGGAGTAATGTCTGGGAATGTAAAAGCAGGTT TCTTGGGCGCAATATTTGCGGGCTTTCTTGCAGGTTATGTTGCAAGGTTTTTAGCAAGAAGATC TGTTCCTGAGTGGTTAAGACCTGTAATGCCTATATTTGTAATTCCGCTAATAAGCACCATTATTG TCGGCTTTTTTATGCTGTATTTTGGTGTTTATATTGGAAAATTTATGGGGGTGCTTGAGAGTGGG CTTAAATCTTTACAGAGTAATTCGGAAACTTTTGGCGTGTTGGGTAAAATTTTCTTAGGCTTAGT ACTAGGTTCAATGATTACTGTTGATATGGGCGGACCTTTTAATAAAGTGGCATTTCTTTTTGGTG TAGGGCTAATTCCTCAAGTGCCAGAAATAATGGGAATGGTAGCAGCAGCAATTCCTGTTCCTCC TATGGCTATGGGGCTTGCAACCTTTTTAGCACCTAAATTGTTTGAAAATGAAGAAAAAGAATCT GGTAAAATAGCCTTTTTAATTTCATTTATTGGTATTAGCGAAGGAGCTATTCCTTTTGCTGCTAG TGATCCCGGACGGGTAATCCCTTCGATAGTGGTAGGGGGAGCTGTATCAAGCATTATTGCCGCT TTTTTAGGCGTTGCTAATCATGCTCCACACGGAGGACCAATAGTACTTCCTGTTATTGATAATA AATTTGGGTTTATTATTGCAATTGCTGTTGGAGTTGCGGTTGCAACAGCTTTGGTAATTTTTTTG AAATCTTTAAAATTAAAGGAATCTGAATGA t519.aa (SEQ ID NO:145) MIKIFKKIYILTLVLGMAHLSFASDNYMVRCSKEEDSTTCIAKLKEIKEKKNYDLFSMGIGIGDPIANI MITIPYINIDFGYGGFIGLKSNNFENYLNGGIDVIFKKQIGQYMKIGGGIGIGADWSKTSLIPPNEEEET DYERIGAVIRIPFIMEYNFAKNLSIGFKIYPAVGPTILLTKPSILFEGIKFNFFGFGFIKFAFN t519.aa (SEQ ID NO:146) DNYMVRCSKEEDSTTCIAKLKEIKEKKNYDLFSMGIGIGDPIANIMITIPYINIDFGYGGFIGLKSNNFE NYLNGGIDVIFKKQIGQYMKIGGGIGIGADWSKTSLIPPNEEEETDYERIGAVIRIPFIMEYNFAKNLSI GFKIYPAVGPTILLTKPSILFEGIKFNFFGFGFIKFAFN f519.nt (SEQ ID NO:147) ATGATAAAAATTTTTAAAAAAATATACATTTTAACATTAGTATTAGGTATGGCACACCT TTCTTTTGCATCTGACAATTATATGGTCAGATGCAGCAAGGAAGAAGATTCAACCACCTGTATC GCAAAGCTTAAAGAAATAAAAGAAAAGAAAAATTATGACTTATTTTCAATGGGCATTGGAATA GGAGATCCTATTGCAAATATTATGATTACAATTCCTTATATAAATATTGATTTTGGATATGGAG GTTTTATTGGCCTTAAGTCAAACAATTTTGAAAATTATCTAAATGGTGGAATAGACGTTATTTTT AAAAAGCAAATTGGACAATATATGAAAATTGGCGGCGGCATTGGAATAGGTGCGGATTGGTCA AAAACATCCCTTATACCCCCTAATGAAGAAGAAGAAACTGATTATGAGAGAATAGGCGCTGTT ATAAGAATTCCTTTTATAATGGAATATAATTTTGCAAAAAATTTATCCATAGGATTCAAAATTT ATCCTGCAGTAGGGCGAACAATATTACTAACAAAACCAAGCATTTTATTTGAAGGAATTAAATT CAATTTTTTTGGATTTGGATTCATAAAATTTGCATTTAATTAA t519.nt (SEQ ID NO:148) GACAATTATATGGTCAGATGCAGCAAGGAAGAAGATTCAACCACCTGTATCGCAAAGCTTAAA GAAATAAAAGAAAAGAAAAATTATGACTTATTTTCAATGGGCATTGGAATAGGAGATCCTATT GCAAATATTATGATTACAATTCCTTATATAAATATTGATTTTGGATATGGAGGTTTTATTGGCCT TAAGTCAAACAATTTTGAAAATTATCTAAATGGTGGAATAGACGTTATTTTTAAAAAGCAAATT GGACAATATATGAAAATTGGCGGCGGCATTGGAATAGGTGCGGATTGGTCAAAAACATCCCTT ATACCCCCTAATGAAGAAGAAGAAACTGATTATGAGAGAATAGGCGCTGTTATAAGAATTCCTT TTATAATGGAATATAATTTTGCAAAAAATTTATCCATAGGATTCAAAATTTATCCTGCAGTAGG GCCAACAATATTACTAACAAAACCAAGCATTTTATTTGAAGGAATTAAATTCAATTTTTTTGGA TTTGGATTCATAAAATTTGCATTTAATTAA f520.aa (SEQ ID NO:149) MRMLLATIILILTTGLLAAQSKSKSMTEDDFDFDKLLAKEESVRRLFGIGFGVGYPLANITISVPYVDI DLGYGGFVGLKPNNFLPYVVMGVDLLFKDEIHKNTMISGGIGIGADWSKGSPEKSNEKLEEEEENE AQQVASLQNRIGVVIRLPLVIEYSFLKNIVIGFKAVATIGTTMLLGSPMSFEGARFNFLGTGFIKIYI t520.aa (SEQ ID NO:150) QSKSKSMTEDDFDFDKLLAKEESVRRLFGIGFGVGYPLANITISVPYVDIDLGYGGFVGLKPNNFLPY VVMGVDLLFKDEIHKNTMISGGIGIGADWSKGSPEKSNEKLEEEEENEAQQVASLQNRIGVVIRLPL VIEYSFLKNIVIGTKAVATIGTTMLLGSPMSFEGARFNFLGTGFIKIYI f520.nt (SEQ ID NO:151) ATGAGAATGCTATTAGCAACAATAATACTTATATTAACAACGGGTTTATTAGCTGCACA ATCCAAAAGCAAAAGTATGACTGAAGATGACTTTGATTTTGATAAACTTCTTGCAAAAGAAGAG TCTGTGCGCCGTTTATTTGGCATAGGTTTTGGAGTTGGATATCCACTTGCAAACATTACAATATC TGTTCCATATGTAGACATAGACCTTGGGTACGGAGGATTCGTAGGGCTTAAACCCAACAATTTC TTGCCCTATGTTGTGATGGGTGTAGATCTTCTATTTAAAGATGAAATACACAAAAACACTATGA TTTCTGGAGGCATTGGAATAGGTGCAGATTGGTCAAAAGGAAGTCCTGAAAAATCAAATGAAA AACTTGAAGAAGAGGAAGAAAATGAAGCACAACAAGTAGCTTCTCTTCAAAATAGAATAGGGG TTGTGATAAGATTGCCTTTGGTAATAGAGTACAGCTTTCTTAAAAATATTGTGATTGGATTTAA AGCTGTTGCTACTATTGGAACAACTATGCTACTTGGCAGCCCAATGTCATTTGAAGGAGCTAGA TTTAATTTCTTAGGCACAGGCTTTATAAAAATATATATATAG t520.nt (SEQ ID NO:152) CAATCCAAAAGCAAAAGTATGACTGAAGATGACTTTGATTTTGATAAACTTCTTGCAAAAGAAG AGTCTGTGCGCCGTTTATTTGGCATAGGTTTTGGAGTTGGATATCCACTTGCAAACATTACAAT ATCTGTTCCATATGTAGACATAGACCTTGGGTACGGAGGATTCGTAGGGCTTAAACCCAACAAT TTCTTGCCCTATGTTGTGATGGGTGTAGATCTTCTATTTAAAGATGAAATACACAAAAACACTA TGATTTCTGGAGGCATTGGAATAGGTGCAGATTGGTCAAAAGGAAGTCCTGAAAAATCAAATG AAAAACTTGAAGAAGAGGAAGAAAATGAAGCACAACAAGTAGCTTCTCTTCAAAATAGAATAG GGGTTGTGATAAGATTGCCTTTGGTAATAGAGTACAGCTTTCTTAAAAATATTGTGATTGGATT TAAAGCTGTTGCTACTATTGGAACAACTATGCTACTTGGCAGCCCAATGTCATTTGAAGGAGCT AGATTTAATTTCTTAGGCACAGGCTTTATAAAAATATATATATAG f523.aa (SEQ ID NO:153) MNIKINFFFTLPIGIFLGLFFPLGIYSSLSHAFIRLSYLSLIPFLIFSIPLGIENIIENKNFKKLFGKTIYYGIL TNLSGVAVSIIAATIYLPQRIPILEKTIQNTCFFEKEALLETFFPKNIFKIFTSSNPNLLSIYMISIIIGTSFY YAKQKGRIARELMLSASNLFYHANGFIVNILNIGIIFITANYAANLKNFKDYPNYTNSITFFLAWTIIIL FVILPTISYRLTKSFKMIYKGIFVSFQNIIFSGLAKDSYSPYVILIEDIKNERINIKKSIIINIPLINFVSKFG TIFVSVISFFIILKSYSSLPISIYEISYMSTLSFVFVFAFPHIPNSLIYIITMLCSTYTKGIELNVSNITPMLPI LISLALLIDFAFNIAIIHIINFKELKDQEKIN t523.aa (SEQ ID NO:154) IENIIENKNFKKLFGKTIYYGILTNLSGVAVSIIAATIYLPQRIPILEKTIQNTCFFEKEALLETFFPKNIF KIFTSSNPNLLSIYMISIIIGTSFYYAKQKGRIARELMLSASNLFYHANGFIVNILNIGIIFITANYAANLK NFKDYPNYTNSITFFLAWTIIILFVILPTISYRLTKSFKMIYKGIFVSFQNIIFSGLAKDSYSPYVILIEDIK NERINIKKSIIINIPLINFVSKFGTIFVSVISFFIILKSYSSLPISIYEISYMSTLSFVFVFAFPHIPNSLIYIITM LCSTYTKGIELNVSNITPMLPILISLALLIDFAFNIAIIHIINFKELKDQEKIN f523.nt (SEQ ID NO:155) ATGAATATAAAAATCAATTTTTTTTTCACTTTGCCTATTGGAATCTTTTTAGGATTGTTTTTCCCT CTTGGAATTTATAGCTCCTTATCACATGCTTTTATAAGATTATCATACTTATCTCTTATTCCCTTT TTAATATTTTCAATTCCATTAGGAATTGAAAATATTATTGAAAATAAAAACTTTAAAAAGCTTTT TGGTAAAACAATTTATTATGGAATTTTAACTAACCTATCTGGAGTTGCTGTATCAATAATAGCT GCAACAATATATCTTCCGCAAAGAATTCCAATACTAGAAAAAACAATACAAAATACATGTTTTT TTGAAAAAGAAGCTTTACTAGAAACATTCTTTCCAAAAAATATTTTCAAAATATTTACATCTAG CAATCCAAATCTACTAAGCATTTACATGATTTCAATAATAATAGGCACAAGTTTTTATTATGCA AAACAAAAAGGCAGAATAGCTAGAGAACTGATGCTAAGCGCATCCAATCTTTTTTACCATGCAA ATGGGTTTATTGTAAACATATTAAATATAGGGATCATTTTTATAACAGCAAATTACGCTGCAAA CTTAAAAAACTTCAAAGATTACCCAAATTATACAAACAGCATAACATTCTTTTTGGCATGGACA ATTATAATTTTATTCGTAATATTGCCAACAATTAGTTATAGATTAACAAAAAGTTTTAAAATGAT ATATAAAGGCATTTTTGTATCATTTCAAAACATAATATTTTCAGGACTTGCAAAAGATTCTTATT CCCCTTATGTGATATTAATAGAAGATATTAAAAACGAAAGAATAAATATAAAAAAATCCATAAT TATAAACATACCTTTAATAAATTTTGTATCTAAATTTGGCACTATTTTTGTTTCAGTAATATCAT TTTTTATAATTTTAAAATCATATTCTAGCTTACCCATTTCTATTTATGAAATAAGCTATATGAGC ACTTTATCATTTGTTTTTGTCTTTGCATTTCCTCATATACCAAATAGTTTAATTTATATAATTACA ATGCTTTGCTCTACATATACAAAAGGAATAGAGCTAAATGTTTCAAACATAACACCAATGCTGC CGATATTAATCTCTTTGGCTTTACTAATCGACTTTGCTTTTAACATTGCAATCATTCATATAATA AACTTCAAAGAATTAAAAGATCAAGAAAAAATTAATTAA f523.nt (SEQ ID NO:156) ATTGAAAATATTATTGAAAATAAAAACTTTAAAAAGCTTTTTGGTAAAACAATTTATTA TGGAATTTTAACTAACCTATCTGGAGTTGCTGTATCAATAATAGCTGCAACAATATATCTTCCGC AAAGAATTCCAATACTAGAAAAAACAATACAAAATACATGTTTTTTTGAAAAAGAAGCTTTACT AGAAACATTCTTTCCAAAAAATATTTTCAAAATATTTACATCTAGCAATCCAAATCTACTAAGC ATTTACATGATTTCAATAATAATAGGCACAAGTTTTTATTATGCAAAACAAAAAGGCAGAATAG CTAGAGAACTGATGCTAAGCGCATCCAATCTTTTTTACCATGCAAATGGGTTTATTGTAAACAT ATTAAATATAGGGATCATTTTTATAACAGCAAATTACGCTGCAAACTTAAAAAACTTCAAAGAT TACCCAAATTATACAAACAGCATAACATTCTTTTTGGCATGGACAATTATAATTTTATTCGTAAT ATTGCCAACAATTAGTTATAGATTAACAAAAAGTTTTAAAATGATATATAAAGGCATTTTTGTA TCATTTCAAAACATAATATTTTCAGGACTTGCAAAAGATTCTTATTCCCCTTATGTGATATTAAT AGAAGATATTAAAAACGAAAGAATAAATATAAAAAAATCCATAATTATAAACATACCTTTAAT AAATTTTGTATCTAAATTTGGCACTATTTTTGTTTCAGTAATATCATTTTTTATAATTTTAAAATC ATATTCTAGCTTACCCATTTCTATTTATGAAATAAGCTATATGAGCACTTTATCATTTGTTTTTG TCTTTGCATTTCCTCATATACCAAATAGTTTAATTTATATAATTACAATGCTTTGCTCTACATAT ACAAAAGGAATAGAGCTAAATGTTTCAAACATAACACCAATGCTGCCGATATTAATCTCTTTGG CTTTACTAATCGACTTTGCTTTTAACATTGCAATCATTCATATAATAAACTTCAAAGAATTAAAA GATCAAGAAAAAATTAATTAA f526.aa (SEQ ID NO:157) MKKEFIMLLLLLQTIMNLNSINTNTSTSIVKELQKNLYIFNSKEYQKDKDTLNEFINSININDKEILQSL EKIKNELFIISVFFNNKKGILIALNLGAEINFKYKISPISISIINNEFEITKILIDYGISLNQIDDTGYSPIFW AIYTNNEKIFEFLKESGADLSFTLKNRKTPMQAAIETENIKLIKSLEKKKIYIDDNFKKLKKLKNKEI VRILVK t526.aa (SEQ ID NO:158) NSINTNTSTSIVKELQKNLYIFNSKEYQKDKDTLNEFINSININDKEILQSLEKIKNELFIISVFFNKKG ILIALNLGAEINFKYKISPISISIINNEFEITKILIDYGISLNQIDDTGYSPIFWAIYTNNEKIFEFLKESGAD LSFTLKNRKTPMQAAIETENIKLIKSLEKKKIYIDDNFKKKLKKLKNKEIVRILVK f526.nt (SEQ ID NO:159) ATGAAAAAAGAATTCATTATGCTTTTACTGTTATTGCAAACAATAATGAATTTAAACTCAATAA ATACTAATACAAGTACTTCAATAGTAAAAGAATTGCAAAAAAATTTATATATTTTCAATAGCAA AGAATATCAAAAAGATAAAGACACTTTAAATGAATTTATAAATTCAATAAATATAAATGACAA AGAAATCTTACAAAGTTTAGAAAAAATCAAAAATGAGCTTTTTATAATATCTGTTTTTTTCAAC AATAAAAAAGGGATTTTAATTGCACTAAATCTTGGAGCAGAAATAAACTTTAAATATAAAATAT CTCCAATTTCAATTTCAATAATAAACAATGAATTTGAAATCACAAAAATATTGATAGATTACGG AATAAGCCTTAATCAAATAGATGATACAGGTTATTCTCCAATATTTTGGGCAATATATACTAAT AACGAAAAAATATTTGAATTTTTAAAAGAAAGCGGAGCTGATTTAAGTTTCACACTTAAAAATA GAAAAACACCAATGCAAGCCGCAATAGAAACAGAAAATATAAAACTAATTAAATCTCTGGAAA AGAAAAAAATTTACATTGACGACAATTTCAAAAAAAAACTTAAAAAGCTTAAAAACAAAGAAA TAGTTCGAATTTTAGTAAAATAG t526.nt (SEQ ID NO:160) AACTCAATAAATACTAATACAAGTACTTCAATAGTAAAAGAATTGCAAAAAAATTTATATATTT TCAATAGCAAAGAATATCAAAAAGATAAAGACACTTTAAATGAATTTATAAATTCAATAAATAT AAATGACAAAGAAATCTTACAAAGTTTAGAAAAAATCAAAAATGAGCTTTTTATAATATCTGTT TTTTTCAACAATAAAAAAGGGATTTTAATTGCACTAAATCTTGGAGCAGAAATAAACTTTAAAT ATAAAATATCTCCAATTTCAATTTCAATAATAAACAATGAATTTGAAATCACAAAAATATTGAT AGATTACGGAATAAGCCTTAATCAAATAGATGATACAGGTTATTCTCCAATATTTTGGGCAATA TATACTAATAACGAAAAAATATTTGAATTTTTAAAAGAAAGCGGAGCTGATTTAAGTTTCACAC TTAAAAATAGAAAAACACCAATGCAAGCCGCAATAGAAACAGAAAATATAAAACTAATTAAAT CTCTGGAAAAGAAAAAAATTTACATTGACGACAATTTCAAAAAAAAACTTAAAAAGCTTAAAA ACAAAGAAATAGTTCGAATTTTAGTAAAATAG f544.aa (SEQ ID NO:161) MTKNRIIWLLVLMVSSTFTATIISNYQNLMLSLVVLANFIPLLMDTSGNAGSQASALIIRELALGTVK VKDFFKVFLKEICVSILVGAILASVNFLRIVFFVAPHHSDKLKIAFVVSSCLMVSLTVAKILGGLLPIV AKLLKLDPALMAGPLITTIADAITLIAYFNIAKWVLVSYAV t544.aa (SEQ ID NO:162) STFTATIISNYQNLMLSLVVLANFIPLLMDTSGNAGSQASALIIRELALGTVKVKDFFKVFLKEICVSIL VGAILASVNFLRIVFFVAPHHSDKLKIAFVVSSCLMVSLTVAKILGGLLPIVAKLLKLDPALMAGPLIT TIADAITLIAYFNIAKWVLVSYAV f544.nt (SEQ ID NO:163) ATGACAAAAAATAGAATAATTTGGCTTTTAGTTCTTATGGTGTCTTCTACTTTTACAGC TACAATTATTTCAAATTATCAAAATTTAATGTTGTCTTTAGTGGTTTTAGCTAATTTTATTCCCC TTTTAATGGATACTTCAGGCAATGCCGGCTCTCAGGCATCTGCGCTAATAATTCGTGAGCTTGC TCTTGGTACTGTCAAGGTAAAAGATTTTTTTAAAGTGTTTTTAAAGGAAATATGTGTTAGCATTC TAGTGGGAGCAATTCTTGCTAGTGTTAATTTTTTAAGAATTGTCTTTTTTGTAGCTCCACACCAT TCTGATAAGCTGAAAATAGCTTTTGTAGTTTCATCTTGCTTGATGGTAAGTTTGACAGTAGCAA AGATATTGGGAGGTCTTTTACCCATTGTTGCTAAACTTTTAAAGTTGGATCCAGCACTTATGGC AGGCCCTTTAATCACTACAATTGCAGATGCTATTACTTTAATAGCTTATTTTAATATAGCAAAAT GGGTTTTAGTTAGCTATGCTGTTTAA t544.nt (SEQ ID NO:164) TCTACTTTTACAGCTACAATTATTTCAAATTATCAAAATTTAATGTTGTCTTTAGTGGTT TTAGCTAATTTTATTCCCCTTTTAATGGATACTTCAGGCAATGCCGGCTCTCAGGCATCTGCGCT AATAATTCGTGAGCTTGCTCTTGGTACTGTCAAGGTAAAAGATTTTTTTAAAGTGTTTTTAAAG GAAATATGTGTTAGCATTCTAGTGGGAGCAATTCTTGCTAGTGTTAATTTTTTAAGAATTGTCTT TTTTGTAGCTCCACACCATTCTGATAAGCTGAAAATAGCTTTTGTAGTTTCATCTTGCTTGATGG TAAGTTTGACAGTAGCAAAGATATTGGGAGGTCTTTTACCCATTGTTGCTAAACTTTTAAAGTT GGATCCAGCACTTATGGCAGGCCCTTTAATCACTACAATTGCAGATGCTATTACTTTAATAGCTT ATTTTAATATAGCAAAATGGGTTTTAGTTAGCTATGCTGTTTAA f545.aa (SEQ ID NO:165) MTKNRIIWLLVLMVSSTFTATIISNYQNLMLSLVVLANFIPLLMDTSGNAGSQASALIIRELALGTVK VKDFFKVFLKEICVSILVGAILASVNFLRIVFFVAPHHSDKLKIAFVVSSCLMVSLTVAKILGGLLPIV AKLLKLDPALMAGPLITTIADAITLIAYFNIAKWVLVSYAV t545.aa (SEQ ID NO:166) GSQASALIIRELALGTVKVKDFFKVFLKEICVSILVGAILASVNFLRIVFFVAPHHSDKLKIAFVVSSCL MVSLTVAKILGGLLPIVAKLLKLDPALMAGPLITTIADAITLIAYFNIAKWVLVSYAV f545.nt (SEQ ID NO:167) ATGACAAAAAATAGAATAATTTGGCTTTTAGTTCTTATGGTGTCTTCTACTTTTACAGCTACAAT TATTTCAAATTATCAAAATTTAATGTTGTCTTTAGTGGTTTTAGCTAATTTTATTCCCCTTTTAAT GGATACTTCAGGCAATGCCGGCTCTCAGGCATCTGCGCTAATAATTCGTGAGCTTGCTCTTGGT ACTGTCAAGGTAAAAGATTTTTTTAAAGTGTTTTTAAAGGAAATATGTGTTAGCATTCTAGTGG GAGCAATTCTTGCTAGTGTTAATTTTTTAAGAATTGTCTTTTTTGTAGCTCCACACCATTCTGAT AAGCTGAAAATAGCTTTTGTAGTTTCATCTTGCTTGATGGTAAGTTTGACAGTAGCAAAGATAT TGGGAGGTCTTTTACCCATTGTTGCTAAACTTTTAAAGTTGGATCCAGCACTTATGGCAGGCCC TTTAATCACTACAATTGCAGATGCTATTACTTTAATAGCTTATTTTAATATAGCAAAATGGGTTT TAGTTAGCTATGCTGTTTAA t545.nt (SEQ ID NO:168) GGCTCTCAGGCATCTGCGCTAATAATTCGTGAGCTTGCTCTTGGTACTGTCAAGGTAAAAGATT TTTTTAAAGTGTTTTTAAAGGAAATATGTGTTAGCATTCTAGTGGGAGCAATTCTTGCTAGTGTT AATTTTTTAAGAATTGTCTTTTTTGTAGCTCCACACCATTCTGATAAGCTGAAAATAGCTTTTGT AGTTTCATCTTGCTTGATGGTAAGTTTGACAGTAGCAAAGATATTGGGAGGTCTTTTACCCATT GTTGCTAAACTTTTAAAGTTGGATCCAGCACTTATGGCAGGCCCTTTAATCACTACAATTGCAG ATGCTATTACTTTAATAGCTTATTTTAATATAGCAAAATGGGTTTTAGTTAGCTATGCTGTTTAA f577.aa (SEQ ID NO:169) MRIKNLILIAILLISPSCSTNKNIVVLTDNKTIPFYINQFNIENKANFIIKFRNNIDLQTIEKENAQIIISKNI GNTNIANHFKSVKINVNPDYPILKHIFKQFNYKIIPLGFDIPILIYKNTHHIKKYINTKYLKEEYENFIK DGKFFISPYVSENLFYVISQINNVRFSFEKNKLNYNENQILKMLEYFSSFLNTKQMDLQKDFFNKYG YLKLNKILLNKKSLLIAGLSDITFYNSLSEQEKSQIKFSYLINDNNEIVISNPNFIGILETSVLTKKFINWI LYKKTQKTLIGFNNQSQSNICFGFANGFTPYKELNLKIKHSIDGISPFIIDETQINSHSYVLSKKTIEKE NLLINEWFFSKANNLKKNKN t577.aa (SEQ ID NO:170) NKNIVVLTDNKTIPFYINQFNIENKANFIIKFRNNIDLQTIEKENAQIIISKNIGNTNIANHFKSVKINYN PDYPILKHIFKQFNYKIIPLGFDIPILIYKNTHHIKKYINTKYLKEEYENFIKDGKFFISPYVSENLFYVIS QINNVRFSFEKNKLNYNENQILKMLEYFSSFLNTKQMDLQKDFFNKYGYLKLNKILLNKKSLLIAGL SDITFYNSLSEQEKSQIKFSYLINDNNEIVISNPNFIGILETSVLTKKFINWILYKKTQKTLIGFNNQSQS NICFGFANGFTPYKELNLKIKHSIDGISPFIIDETQINSHSYVLSKKTIEKENLLINEWFFSKANNLKKN KN f577.nt (SEQ ID NO:171) ATGAGAATAAAAAATTTAATACTAATAGCAATTTTATTAATTAGCCCTAGCTGTTCAAC AAATAAGAACATCGTTGTACTAACTGACAATAAAACAATACCATTTTATATAAATCAATTTAAT ATAGAAAATAAAGCAAATTTTATAATTAAGTTTAGAAATAATATTGATCTGCAAACAATAGAAA AAGAAAATGCACAAATAATTATTTCTAAAAACATTGGTAACACAAATATTGCTAACCATTTTAA ATCTGTAAAAATCAATTATAATCCAGATTATCCTATCTTAAAGCATATTTTCAAGCAATTTAACT ACAAAATTATTCCATTGGGCTTTGACATTCCTATTTTAATCTATAAAAATACACATCATATTAAA AAATACATAAACACTAAATATCTAAAAGAAGAATACGAAAATTTCATTAAAGATGGAAAATTTT TTATATCGCCTTATGTTTCTGAAAATTTATTTTATGTGATTTCTCAAATAAATAATGTGAGATTT TCTTTTGAAAAAAATAAATTAAATTATAATGAGAATCAAATTTTAAAAATGCTAGAATATTTCT CATCATTTTTAAATACAAAACAAATGGACTTGCAAAAAGATTTCTTTAATAAATACGGCTACCT AAAGTTAAATAAAATATTGCTTAATAAAAAATCTCTTTTAATAGCAGGATTGAGCGATATAACC TTCTACAATAGCTTAAGCGAACAAGAGAAGTCACAAATAAAATTTTCCTATTTAATAAACGATA ACAATGAAATTGTTATCTCAAACCCAAATTTTATTGGCATTTTAGAAACATCTGTTTTAACTAAA AAATTTATCAACTGGATATTGTATAAAAAAACTCAAAAAACCCTAATTGGATTTAACAATCAAT CCCAATCAAATATATGTTTTGGATTTGCCAATGGTTTTACCCCTTACAAAGAATTAAATTTAAAA ATAAAACATTCAATTGATGGAATATCTCCTTTTATTATTGACGAAACTCAAATCAATAGCCATTC CTATGTATTAAGCAAAAAAACAATTGAAAAAGAAAACTTACTAATAAATGAATGGTTTTTCTCT AAAGCTAATAATCTAAAAAAAAATAAAAATTAA t577.nt (SEQ ID NO:172) AATAAGAACATCGTTGTACTAACTGACAATAAAACAATACCATTTTATATAAATCAATTTAATA TAGAAAATAAAGCAAATTTTATAATTAAGTTTAGAAATAATATTGATCTGCAAACAATAGAAAA AGAAAATGCACAAATAATTATTTCTAAAAACATTGGTAACACAAATATTGCTAACCATTTTAAA TCTGTAAAAATCAATTATAATCCAGATTATCCTATCTTAAAGCATATTTTCAAGCAATTTAACTA CAAAATTATTCCATTGGGCTTTGACATTCCTATTTTAATCTATAAAAATACACATCATATTAAAA AATACATAAACACTAAATATCTAAAAGAAGAATACGAAAATTTCATTAAAGATGGAAAATTTTT TATATCGCCTTATGTTTCTGAAAATTTTATTTTATGTGATTTCTCAAATAAATAATGTGAGATTTT CTTTTGAAAAAAATAAATTAAATTATAATGAGAATCAAATTTTAAAAATGCTAGAATATTTCTC ATCATTTTTAAATACAAAACAAATGGACTTGCAAAAAGATTTCTTTAATAAATACGGCTACCTA AAGTTAAATAAAATATTGCTTAATAAAAAATCTCTTTTAATAGCAGGATTGAGCGATATAACCT TCTACAATAGCTTAAGCGAACAAGAGAAGTCACAAATAAAATTTTCCTATTTAATAAACGATAA CAATGAAATTGTTATCTCAAACCCAAATTTTATTGGCATTTTAGAAACATCTGTTTTAACTAAAA AATTTATCAACTGGATATTGTATAAAAAAACTCAAAAAACCCTAATTGGATTTAACAATCAATC CCAATCAAATATATGTTTTGGATTTGCCAATGGTTTTACCCCTTACAAAGAATTAAATTTAAAA ATAAAACATTCAATTGATGGAATATCTCCTTTTATTATTGACGAAACTCAAATCAATAGCCATTC CTATGTATTAAGCAAAAAAACAATTGAAAAAGAAAACTTACTAATAAATGAATGGTTTTTCTCT AAAGCTAATAATCTAAAAAAAAATAAAAATTAA f584.aa (SEQ ID NO:173) MIKTILLLVLYPVVVFSQISANQYFEGIYAKYQNIEDMQATINFTLKGLKQTGVLLYKFPDKFIINLDS NNQVFVSDGEFLTVYVPSLGTSFNQQLLKGSSGGGLMKVLNSEYSVSYTNSPNLEDLDSSEPGKYIK LTFSRKLYKGAATINSFILAFAPDGIIRRITAFPTSGGREIVIDLTAVKFNVGILDSKFKYDPPKSSNKVD NFLYDIKKN t584.aa (SEQ ID NO:174) QISANQYFEGIYAKYQNIEDMQATINFTLKGLKQTGVLLYKFPDKFIINLDSNNQVFVSDGEFLTVY VPSLGTSFNQQLLKGSSGGGLMKVLNSEYSVSYTNSPNLEDLDSSEPGKYIKLTFSRKLYKGAATINS FIIAFAPDGIIRRITAFPTSGGREIVIDLTAVKFNVGILDSKFKYDPPKSSNKVDNFLYDIKKN t584.nt (SEQ ID NO:175) ATGATAAAAACAATACTTTTATTAGTTTTGTATCCTGTTGTTGTGTTTTCTCAAATATCTGCAAA TCAATATTTTGAAGGAATTTATGCTAAATATCAAAATATAGAGGACATGCAAGCAACAATTAAT TTTACTTTAAAGGGGTTAAAGCAAACAGGTGTTTTGCTTTATAAGTTTCCAGACAAGTTTATTAT CAATTTAGATTCAAATAATCAAGTTTTTGTAAGTGATGGTGAATTTTTGACAGTTTATGTTCCAT CTCTTGGGACTTCTTTTAATCAGCAATTATTAAAGGGTAGTAGTGGGGGAGGTCTTATGAAAGT TTTAAATAGTGAGTATAGCGTATCTTATACCAATTCTCCAAATTTAGAAGATCTCGATTCATCTG AGCCTGGAAAATATATTAAATTAACCTTTTCTAGAAAGCTTTACAAGGGGGCTGCTACTATTAA TTCTTTTATTATTGCTTTTGCTCCGGATGGAATAATTAGAAGAATTACTGCTTTTCCTACTAGTG GTGGGCGCGAAATAGTTATTGATTTGACTGCTGTGAAGTTTAATGTTGGAATTCTTGATAGCAA ATTTAAATATGATCCTCCAAAATCTTCAAATAAGGTAGATAATTTTTTATATGATATTAAAAA AATTAA t584.nt (SEQ ID NO:176) CAAATATCTGCAAATCAATATTTTGAAGGAATTTATGCTAAATATCAAAATATAGAGGACATGC AAGCAACAATTAATTTTACTTTAAAGGGGTTAAAGCAAACAGGTGTTTTGCTTTATAAGTTTCC AGACAAGTTTATTATCAATTTAGATTCAAATAATCAAGTTTTTGTAAGTGATGGTGAATTTTTG ACAGTTTATGTTCCATCTCTTGGGACTTCTTTTAATCAGCAATTATTAAAGGGTAGTAGTGGGG GAGGTCTTATGAAAGTTTTAAATAGTGAGTATAGCGTATCTTATACCAATTCTCCAAATTTAGA AGATCTCGATTCATCTGAGCCTGGAAAATATATTAAATTAACCTTTTCTAGAAAGCTTTACAAG GGGGCTGCTACTATTAATTCTTTTATTATTGCTTTTGCTCCGGATGGAATAATTAGAAGAATTAC TGCTTTTCCTACTAGTGGTGGGCGCGAAATAGTTATTGATTTGACTGCTGTGAAGTTTAATGTTG GAATTCTTGATAGCAAATTTAAATATGATCCTCCAAAATCTTCAAATAAGGTAGATAATTTTTT ATATGATATTAAAAAAAATTAA t596.aa (SEQ ID NO:177) MKERCLYLLVFVALCVNNLFSDDYLIYDFDLSLNEFLEVSTRKDNLEPMVDSNRILLFYPPKKEIRKI FAAFDFDQYSKKYLFKKNEHGVFFVKVNIPHGTSSIKYRLIVDGVWTNDEYNKNVVYNEDLIPFSKI EIAKEKSSYISLRNPIQSYDNNEIEIFYIGRPGQIVTIAGSFNNFNPFLNRLIEKEDNKGIYTIKLKNLPK DRIYYYFIDSGNKVIDKNNVNRINLYFVEGIDNKIDFEVSYFDHK t596.aa (SEQ ID NO:178) DDYLIYDFDLSLNEFLEVSTRKDNLEPMVDSNRILLFYPPKKEIRKIFAAFDFDQYSKKYLFKKNEHG VFFVKVNIPHGTSSIKYRLIVDGVWTNDEYNKNVVYNEDLIPFSKIEIAKEKSSYISLRNPIQSYDNNE IEIFYIGRPGQIVTIAGSFNNFNPFLNRLIEKEDNKGIYTIKLKNLPKDRIYYYFIDSGNKVIDKNNVNRI NLYFVEGIDNKIDFEVSYFDHK t596.nt (SEQ ID NO:179) ATGAAAGAAAGGTGTTTGTATTTATTGGTTTTTGTAGCTTTATGTGTTAACAATCTTTTTTCAGA TGATTATTTAATTTATGACTTTGATTTAAGTTTAAATGAATTTCTAGAAGTTTCAACAAGAAAAG ACAATCTTGAGCCTATGGTTGATTCCAATCGTATATTATTGTTTTATCCTCCTAAAAAAGAAATT AGAAAAATTTTTGCTGCCTTTGACTTTGATCAGTATTCTAAGAAATATTTATTCAAAAAAAATG AGCATGGAGTTTTTTTTGTTAAAGTTAATATTCCTCATGGCACAAGCAGTATAAAATATAGGCT TATTGTAGACGGTGTTTGGACTAATGACGAGTATAATAAAAATGTAGTTTATAATGAGGATTTA ATCCCATTTTCTAAAATTGAGATCGCTAAAGAGAAGTCCAGCTATATTTCTTTGAGAAATCCAA TACAATCATATGATAACAATGAAATTGAAATTTTTTACATAGGTCGTCCTGGACAAATAGTTAC AATAGCTGGTAGTTTTAACAATTTTAATCCTTTTTTAAATAGGCTTATTGAGAAAGAGGACAAT AAGGGAATTTATACTATTAAGCTTAAAAATTTACCCAAGGATAGAATTTATTATTATTTTATTG ATTCTGGTAACAAAGTAATAGATAAAAATAATGTTAATAGAATTAATTTATATTTTGTTGAGGG AATTGATAATAAAATAGATTTCGAAGTTTCCTATTTTGATCATAAGTAA t596.nt (SEQ ID NO:180) GATGATTATTTAATTTATGACTTTGATTTAAGTTTAAATGAATTTCTAGAAGTTTCAAC AAGAAAAGACAATCTTGAGCCTATGGTTGATTCCAATCGTATATTATTGTTTTATCCTCCTAAAA AAGAAATTAGAAAAATTTTTGCTGCCTTTGACTTTGATCAGTATTCTAAGAAATATTTATTCAA AAAAAATGAGCATGGAGTTTTTTTTGTTAAAGTTAATATTCCTCATGGCACAAGCAGTATAAAA TATAGGCTTATTGTAGACGGTGTTTGGACTAATGACGAGTATAATAAAAATGTAGTTTATAATG AGGATTTAATCCCATTTTCTAAAATTGAGATCGCTAAAGAGAAGTCCAGCTATATTTCTTTGAG AAATCCAATACAATCATATGATAACAATGAAATTGAAATTTTTTACATAGGTCGTCCTGGACAA ATAGTTACAATAGCTGGTAGTTTTAACAATTTTAATCCTTTTTTAAATAGGCTTATTGAGAAAGA GGACAATAAGGGAATTTATACTATTAAGCTTAAAAATTTACCCAAGGATAGAATTTATTATTAT TTTATTGATTCTGGTAACAAAGTAATAGATAAAAATAATGTTAATAGAATTAATTTATATTTTGT TGAGGGAATTGATAATAAAATAGATTTCGAAGTTTCCTATTTTGATCATAAGTAA f598.aa (SEQ ID NO:181) MRQRVMIAMALSCHPSLLIADEPTTALDVTIQEQILLLIKNLSKKFNTSTIFITHDLAVVAEICDTVSV MYQGKIVEEGTVEEIFNNPKHPYTIGLLKSILTLEHDPNKKLYSTKENPMKITKTSTEEF t598.aa (SEQ ID NO:182) EPTTALDVTIQEQILLLIKNLSKKFNTSTIFITHDLAVVAEICDTVSVMYQGKIVEEGTVEEIFNNPKH PYTIGLLKSILTLEHDPNKKLYSTKENPMKITKTSTEEF f598.nt (SEQ ID NO:183) ATGAGACAAAGAGTTATGATTGCCATGGCTCTTAGCTGTCATCCATCCTTATTAATAGCAGATG AACCAACAACAGCCCTTGATGTTACAATCCAAGAGCAAATATTATTATTAATCAAAAACCTATC TAAAAAATTCAATACTTCTACCATATTTATAACTCATGATCTTGCGGTTGTTGCTGAAATTTGTG ATACAGTATCTGTAATGTATCAAGGAAAAATTGTAGAAGAAGGAACAGTAGAGGAAATATTTA ACAATCCTAAGCATCCTTACACCATTGGGCTTTTAAAATCAATTCTTACGCTAGAACACGATCC AAATAAAAAGCTTTATTCAACAAAAGAAAACCCTATGAAGATCACAAAAACCAGCACCGAGGA GTTTTAA t598.nt (SEQ ID NO:184) GAACCAACAACAGCCCTTGATGTTACAATCCAAGAGCAAATATTATTATTAATCAAAAACCTAT CTAAAAAATTCAATACTTCTACCATATTTATAACTCATGATCTTGCGGTTGTTGCTGAAATTTGT GATACAGTATCTGTAATGTATCAAGGAAAAATTGTAGAAGAAGGAACAGTAGAGGAAATATTT AACAATCCTAAGCATCCTTACACCATTGGGCTTTTAAAATCAATTCTTACGCTAGAACACGATC CAAATAAAAAGCTTTATTCAACAAAAGAAAACCCTATGAAGATCACAAAAACCAGCACCGAGG AGTTTTAA f600.aa (SEQ ID NO:185) MAIMERSIIGLFIALAFVSWLTVARVVRGQVQSLSSSEFIQAAKTLGATNQRIILKHLIPNSIGMIVIFT TIRVPSFIMAEAFLSFLGLGISAPMTSWGELVQNGIATFVEYPWKVFIPAIVMTIFLLFMNFLGDGLRD AFDPKDSI t600.aa (SEQ ID NO:186) RVVRGQVQSLSSSEFIQAAKTLGATNQRIILKHLIPNSIGMIVIFTTIRVPSFIMAEAFLSFLGLGISAPM TSWGELVQNGIATFVEYPWKVFIPAIVMTIFLLFMNFLGDGLRDAFDPKDSI f600.nt (SEQ ID NO:187) ATGGCAATAATGGAAAGAAGTATAATCGGCTTATTCATAGCACTTGCATTTGTATCATGGTTAA CAGTAGCTCGAGTTGTACGAGGCCAAGTACAATCACTATCAAGTTCGGAATTTATACAAGCAGC CAAAACCCTTGGTGCAACAAATCAAAGAATAATCTTAAAACACTTGATCCCTAATAGCATTGGA ATGATAGTTATATTCACAACAATAAGGGTTCCAAGCTTTATTATGGCTGAAGCATTTTTATCCTT TTTAGGACTTGGAATTTCAGCTCCAATGACAAGCTGGGGAGAATTAGTGCAAAATGGAATTGCT ACATTTGTTGAATATCCATGGAAAGTTTTTATTCCAGCTATAGTTATGACAATATTTCTATTATT TATGAACTTTTTAGGTGATGGGCTAAGGGATGCTTTTGATCCAAAAGATAGCATCTAA t600.nt (SEQ ID NO:188) CGAGTTGTACGAGGCCAAGTACAATCACTATCAAGTTCGGAATTTATACAAGCAGCCAAAACCC TTGGTGCAACAAATCAAAGAATAATCTTAAAACACTTGATCCCTAATAGCATTGGAATGATAGT TATATTCACAACAATAAGGGTTCCAAGCTTTATTATGGCTGAAGCATTTTTATCCTTTTTAGGAC TTGGAATTTCAGCTCCAATGACAAGCTGGGGAGAATTAGTGCAAAATGGAATTGCTACATTTGT TGAATATCCATGGAAAGTTTTTATTCCAGCTATAGTTATGACAATATTTCTATTATTTATGAACT TTTTAGGTGATGGGCTAAGGGATGCTTTTGATCCAAAAGATAGCATCTAA f603.aa (SEQ ID NO:189) MLKFTLKKILGIIPTLLVIIFLCFFVMRMAPGSPFDSEKPIDPQVKARLMEKYHLDKPFYIQAFYYITN ALRGDLGPSLKKKDLTVSQYIKLGFPKSLTLGVISLIISLSIGIPIGILAAIYKNTYVDYIITSIAILGISIPL FVIGPILQYFFAIKWGLLYTSGWITERGGFSNLILPIITLSMPNVAIFARIIRGSMLEIIQSDFIRTARAKG LSFKKIVIKHMLRGAMLPVVSYIGPAFAAIISGSVVIEKIFRIAGMGMFITESALNRDYPVLMGGLLV YSIILLISILISDIIYKILDPRV t603.aa (SEQ ID NO:190) SPFDSEKPIDPQVKARLMEKYHLDKPFYIQAFYYITNALRGDLGPSLKKKDLTVSQYIKLGFPKSLTL GVISLIISLSIGIPIGILAAIYKNTYVDYIITSIAILGISIPLFVIGPILQYFFAIKWGLLYTSGWITERGGFSN LILPIITLSMPNVAIFARIIRGSMLEIIQSDFIRTARAKGLSFKKIVIKHMLRGAMLPVVSYIGPAFAAIIS GSVVIEKIFRIAGMGMFITESALNRDYPVLMGGLLVYSIILLISILISDIIYKILDPRV f603.nt (SEQ ID NO:191) ATGTTAAAGTTTACTTTAAAGAAAATATTAGGAATAATACCAACTTTACTGGTAATAATTTTTTT ATGCTTTTTTGTAATGAGAATGGCTCCTGGAAGTCCATTTGATTCTGAAAAACCTATTGATCCTC AAGTAAAAGCAAGATTGATGGAAAAATATCACCTTGACAAGCCTTTTTATATTCAAGCTTTTTA TTACATTACAAACGCTCTCAGGGGAGATCTGGGACCTTCTTTGAAAAAGAAAGACCTTACAGTT AGTCAATACATAAAATTAGGATTTCCAAAATCACTTACACTAGGAGTAATATCCCTTATTATAT CACTATCAATAGGAATACCAATAGGTATATTAGCTGCCATTTATAAAAATACTTATGTGGATTA TATAATAACATCAATAGCAATATTGGGGATTTCAATACCATTATTCGTAATAGGGCCAATTTTA CAATATTTTTTTGCAATTAAATGGGGTTTGCTTTATACCTCTGGATGGATTACAGAAAGAGGAG GATTTTCAAATTTAATTCTACCCATAATAACTCTTAGCATGCCCAACGTAGCTATTTTCGCAAGA ATAATCAGAGGATCAATGCTAGAAATAATACAAAGCGACTTTATAAGAACTGCGCGTGCAAAA GGGCTAAGCTTCAAAAAGATAGTTATAAAGCATATGTTAAGAGGAGCAATGTTGCCTGTAGTA AGCTATATAGGTCCAGCATTTGCTGCTATAATATCTGGAAGCGTGGTTATTGAAAAAATATTTA GAATTGCTGGAATGGGAATGTTTATAACAGAATCCGCACTAAACAGAGATTACCCAGTATTAAT GGGCGGATTGTTAGTATATTCAATAATACTGCTTATTTCTATATTAATATCAGATATTATATATA AAATATTAGATCCAAGAGTATAA t603.nt (SEQ ID NO:192) AGTCCATTTGATTCTGAAAAACCTATTGATCCTCAAGTAAAAGCAAGATTGATGGAAAAATATC ACCTTGACAAGCCTTTTTATATTCAAGCTTTTTATTACATTACAAACGCTCTCAGGGGAGATCTG GGACCTTCTTTGAAAAAGAAAGACCTTACAGTTAGTCAATACATAAAATTAGGATTTCCAAAAT CACTTACACTAGGAGTAATATCCCTTATTATATCACTATCAATAGGAATACCAATAGGTATATT AGCTGCCATTTATAAAAATACTTATGTGGATTATATAATAACATCAATAGCAATATTGGGGATT TCAATACCATTATTCGTAATAGGGCCAATTTTACAATATTTTTTTGCAATTAAATGGGGTTTGCT TTATACCTCTGGATGGATTACAGAAAGAGGAGGATTTTCAAATTTAATTCTACCCATAATAACT CTTAGCATGCCCAACGTAGCTATTTTCGCAAGAATAATCAGAGGATCAATGCTAGAAATAATAC AAAGCGACTTTATAAGAACTGCGCGTGCAAAAGGGCTAAGCTTCAAAAAGATAGTTATAAAGC ATATGTTAAGAGGAGCAATGTTGCCTGTAGTAAGCTATATAGGTCCAGCATTTGCTGCTATAAT ATCTGGAAGCGTGGTTATTGAAAAAATATTTAGAATTGCTGGAATGGGAATGTTTATAACAGAA TCCGCACTAAACAGAGATTACCCAGTATTAATGGGCGGATTGTTAGTATATTCAATAATACTGC TTATTTCTATATTAATATCAGATATTATATATAAAATATTAGATCCAAGAGTATAA f607.aa (SEQ ID NO:193) MKYIKIALMLIIFSLIACISNAKKEKIVFRVSNLSEPSSLDPQLSTDLYGSNIITNLFLGLAVKDSQTGK YKPGLAKSWNISEDGIIYTFNLREDIVWSDGVAITAEEIKKSYLRILNKKTAAMYANLIKSTIKNAQE YFDETVPESELGIKAIDSKTLEITLTSPKPYFPDMLTHSAYIPVPMHIVEKYGENWTNPENIVVSGAY KLKERSINDKIVIEKNEKYYNAKNVEIDEVIFYPTEGSVAYNMYINGELDFLQGAEKNNLEEIKIRDD YYSGLKNGMAYIAFNTTIKPLDNLKVRQAISLAIDRETLTKVVLKGSSDPTRNLTPKFDDYSYGKNL ILFDPENAKKLLAEAGYPDGKGFPTLKYKISEGRPTTAEFLQEQFKKILNINLEIENEEWTTFLGSRRT GNYQMSSVGWIGDYFDPLTFLDSLFTTENHFLGAYKYSNKEYDALIKKSNFELDPIKRQDILRQAEEI IAEKDFPMAPLYIPKSHYLFRNDKWTGWVPNIAESYLYEDIKTKK t607.aa (SEQ ID NO:194) CISNAKKEKIVFRVSNLSEPSSLDPQLSTDLYGSNIITNLFLGLAVKDSQTGKYKPGLAKSWNISEDGI IYTFNLREDIVWSDGVAITAEEIKKSYLRILNKKTAAMYANLIKSTIKNAQEYFDETVPESELGIKAID SKTLEITLTSPKPYFPDMLTHSAYIPVPMHIVEKYGENWTNPENIVVSGAYKLKERSINDKIVIEKNE KYYNAKNVEIDEVIFYPTEGSVAYNMYINGELDFLQGAEKNNLEEIKIRDDYYSGLKNGMAYIAFN TTIKPLDNLKVRQAISLAIDRETLTKVVLKGSSDPTRNLTPKFDDYSYGKNLILFDPENAKKLLAEAG YPDGKGTPFLKYKISEGRPTTAEFLQEQFKKILNINLEIENEEWTTFLGSRRTGNYQMSSVGWIGDYF DPLTFLDSLFTTENHTLGAYKYSNKEYDALIKKSNFELDPIKRQDILRQAEEIIAEKDFPMAPLYIPKS HYLFRNDKWTGWVPNIAESYLYEDIKTKK f607.nt (SEQ ID NO:195) ATGAAATATATAAAAATAGCCTTAATGCTAATAATTTTTTCTTTAATAGCATGTATTAGTAATGC TAAAAAAGAAAAAATAGTTTTCAGAGTATCAAACTTAAGCGAGCCATCATCACTTGATCCTCAA CTCTCAACAGACCTTTACGGTAGCAACATTATTACAAACCTATTCTTAGGCCTAGCGGTAAAAG ATTCTCAAACTGGAAAATATAAACCAGGACTTGCAAAAAGTTGGAATATTTCTGAAGATGGAAT TATTTACACATTTAACCTAAGAGAAGATATAGTTTGGAGCGATGGAGTTGCCATTACTGCCGAG GAGATAAAAAAATCATACCTAAGAATTTTAAATAAAAAAACAGCTGCAATGTATGCTAATTTAA TAAAATCTACAATAAAAAATGCACAAGAATATTTCGATGAGACAGTGCCTGAATCTGAGCTTGG CATAAAGGCTATTGACAGCAAAACCTTAGAGATAACATTAACATCTCCAAAGCCTTATTTTCCT GATATGCTAACACACTCAGCATACATACCAGTTCCAATGCATATTGTTGAAAAATATGGAGAAA ATTGGACAAATCCTGAAAATATAGTTGTTAGTGGCGCATACAAACTTAAAGAAAGATCAATTAA CGATAAAATCGTAATAGAAAAAAATGAAAAATACTATAATGCAAAAAATGTAGAAATTGATGA AGTAATATTTTACCCAACAGAAGGTAGCGTGGCTTACAATATGTACATAAACGGTGAACTCGAT TTTCTACAAGGAGCAGAAAAGAATAATTTAGAAGAAATTAAAATAAGAGATGATTATTATTCTG GGTTAAAAAACGGAATGGCATACATAGCATTCAATACAACAATAAAACCACTAGACAATTTAA AAGTTAGACAAGCCATCTCCCTTGCCATTGACAGAGAAACTTTAACTAAAGTAGTTTTAAAGGG AAGTTCAGATCCAACAAGAAATCTAACTCCAAAATTTGATGATTATTCTTATGGAAAAAATTTA ATACTATTTGATCCTGAGAATGCAAAAAAACTTTTAGCTGAAGCTGGATATCCGGATGGGAAAG GATTCCCCACATTAAAATATAAAATATCGGAGGGAAGACCAACAACAGCAGAATTTTTGCAAG AACAATTTAAAAAAATACTAAACATTAACTTAGAAATCGAGAATGAAGAATGGACAACATTCC TAGGAAGCAGAAGAACTGGAAATTACCAAATGTCAAGCGTGGGGTGGATAGGAGATTATTTTG ATCCCTTAACATTCTTAGACAGCTTATTTACAACAGAAAATCATTTTTTAGGAGCGTACAAATA TTCAAACAAAGAGTATGATGCTTTAATAAAAAAATCTAATTTTGAACTTGATCCAATAAAAAGA CAAGACATTTTAAGACAAGCTGAAGAGATAATAGCAGAAAAAGACTTTCCTATGGCACCTTTAT ATATACCCAAATCTCATTATCTTTTCAGAAATGATAAATGGACAGGGTGGGTACCAAATATCGC AGAAAGCTATTTATATGAAGATATTAAAACTAAAAAATAA t607.nt (SEQ ID NO:196) TGTATTAGTAATGCTAAAAAAGAAAAAATAGTTTTCAGAGTATCAAACTTAAGCGAGCCATCAT CACTTGATCCTCAACTCTCAACAGACCTTTACGGTAGCAACATTATTACAAACCTATTCTTAGGC CTAGCGGTAAAAGATTCTCAAACTGGAAAATATAAACCAGGACTTGCAAAAAGTTGGAATATT TCTGAAGATGGAATTATTTACACATTTAACCTAAGAGAAGATATAGTTTGGAGCGATGGAGTTG CCATTACTGCCGAGGAGATAAAAAAATCATACCTAAGAATTTTAAATAAAAAAACAGCTGCAA TGTATGCTAATTTAATAAAATCTACAATAAAAAATGCACAAGAATATTTCGATGAGACAGTGCC TGAATCTGAGCTTGGCATAAAGGCTATTGACAGCAAAACCTTAGAGATAACATTAACATCTCCA AAGCCTTATTTTCCTGATATGCTAACACACTCAGCATACATACCAGTTCCAATGCATATTGTTGA AAAATATGGAGAAAATTGGACAAATCCTGAAAATATAGTTGTTAGTGGCGCATACAAACTTAA AGAAAGATCAATTAACGATAAAATCGTAATAGAAAAAAATGAAAAATACTATAATGCAAAAAA TGTAGAAATTGATGAAGTAATATTTTACCCAACAGAAGGTAGCGTGGCTTACAATATGTACATA AACGGTGAACTCGATTTTCTACAAGGAGCAGAAAAGAATAATTTAGAAGAAATTAAAATAAGA GATGATTATTATTCTGGGTTAAAAAACGGAATGGCATACATAGCATTCAATACAACAATAAAAC CACTAGACAATTTAAAAGTTAGACAAGCCATCTCCCTTGCCATTGACAGAGAAACTTTAACTAA AGTAGTTTTAAAGGGAAGTTCAGATCCAACAAGAAATCTAACTCCAAAATTTGATGATTATTCT TATGGAAAAAATTTAATACTATTTGATCCTGAGAATGCAAAAAAACTTTTAGCTGAAGCTGGAT ATCCGGATGGGAAAGGATTCCCCACATTAAAATATAAAATATCGGAGGGAAGACCAACAACAG CAGAATTTTTGCAAGAACAATTTAAAAAAATACTAAACATTAACTTAGAAATCGAGAATGAAG AATGGACAACATTCCTAGGAAGCAGAAGAACTGGAAATTACCAAATGTCAAGCGTGGGGTGGA TAGGAGATTATTTTGATCCCTTAACATTCTTAGACAGCTTATTTACAACAGAAAATCATTTTTTA GGAGCGTACAAATATTCAAACAAAGAGTATGATGCTTTAATAAAAAAATCTAATTTTGAACTTG ATCCAATAAAAAGACAAGACATTTTAAGACAAGCTGAAGAGATAATAGCAGAAAAAGACTTTC CTATGGCACCTTTATATATACCCAAATCTCATTATCTTTTCAGAAATGATAAATGGACAGGGTG GGTACCAAATATCGCAGAAAGCTATTTATATGAAGATATTAAAACTAAAAAATAA f611.aa (SEQ ID NO:197) MKKIFLFLFISFYLFGFEDSSLKIGIDDVYVEAHEEGFHLFIRKKPAIKSVILTESFEIPDKKKDVATYSF RTLSYNKVNGDEIRILNGRVIKNKELLSLTSSTPVPNKKTGEAFHILIPKKLKYGFPNFSTRSGDIDLE VLKSKKEPFWFSIRSFEKKYNDYLGRYQDNAYELLFKDDQNQGKIEFNELKDTFTKFSDEVVIANN GIDIVDKINKILKNSEDSVVDLDLVLVVDVTDSMKSNIEILKEHLTSIIEPQLQKFKSYRIGLVFYKDY LEDFLTKAFDFNTIPYLNNILKYVNVGGGGDYPEAVFEGIDAAVTQFDWRAERRFIIVIGDAPPHEYP RGSIVYKDVINSAKEKDITIYGIIFQ t611.aa (SEQ ID NO:198) FEDSSLKIGIDDVYVEAHEEGFHLFIRKKPAIKSVILTESFEIPDKKKDVATYSFRTLSYNKVNGDEIRI LNGRVIKNKELLSLTSSTPVPNKKTGEAFHILIPKKLKYGFPNFSTRSGDIDLEVLKSKKEPFWFSIRSF EKKYNDYLGRYQDNAYELLFKDDQNQGKIEFNELKDTFTKFSDEVVIANNGIDIVDKINKILKNSED SVYDLDLVLVVDVTDSMKSNIEILKEHLFSIIEPQLQKFKSYRIGLVFYKDYLEDFLTKAFDFNTIPYL NNILKYVNVGGGGDYPEAVFEGIDAAVTQFDWRAERRFIIVIGDAPPHEYPRGSIVYKDVINSAKEK DITIYGIIFQ f611.nt (SEQ ID NO:199) ATGAAGAAAATTTTTTTATTTCTTTTTATTAGTTTTTATTTGTTTGGATTTGAAGATAGTTCTTTG AAAATAGGTATTGATGATGTTTATGTTGAGGCTCATGAAGAGGGATTTCATCTTTTTATTAGAA AAAAACCTGCAATCAAATCAGTAATATTGACAGAGTCTTTTGAAATTCCTGATAAGAAAAAAGA TGTGGCTACTTATTCATTTCGTACATTAAGTTATAATAAGGTTAATGGAGATGAAATTCGGATT TTAAATGGAAGAGTTATTAAGAATAAAGAACTTTTATCATTGACATCTTCCACCCCTGTTCCTA ATAAAAAGTTTGGAGAAGCTTTTCATATATTGATTCCAAAAAAATTAAAATATGGATTTCCAAA TTTTTCAACAAGAAGTGGTGATATTGACTTAGAAGTATTAAAAAGTAAAAAAGAGCCCTTTTGG TTTTCTATAAGATCTTTTGAGAAAAAATATAATGATTATTTGGGCAGATATCAAGACAATGCTT ATGAATTGCTTTTCAAGGATGATCAAAATCAGGGAAAAATTGAATTTAATGAATTAAAAGATAC TTTTACAAAATTTTCAGATGAGGTTGTTATTGCTAATAATGGCATTGATATTGTTGATAAAATA AACAAAATTTTAAAAAACTCAGAAGATTCAGTTTATGATTTAGATTTAGTGCTTGTTGTTGATG TTACTGATAGTATGAAAAGCAATATTGAGATTCTAAAAGAGCATTTGTTTTCAATAATAGAACC TCAACTTCAAAAGTTTAAATCCTACAGAATAGGTCTTGTTTTTTATAAAGACTATCTTGAAGATT TTTTAACCAAAGCTTTTGATTTTAATACTATTCCTTATTTAAATAATATTCTTAAGTATGTTAAT GTTGGTGGCGGTGGGGATTATCCAGAAGCTGTTTTTGAGGGGATTGATGCTGCTGTGACCCAAT TTGATTGGCGGGCAGAAAGAAGGTTTATTATTGTTATAGGAGATGCACCTCCTCATGAGTATCC AAGAGGGTCTATTGTTTATAAAGATGTTATCAATTCTGCAAAGGAAAAAGATATTACAATTTAT GGAATAATATTTCAGTAA t611.nt (SEQ ID NO:200) TTTGAAGATAGTTCTTTGAAAATAGGTATTGATGATGTTTATGTTGAGGCTCATGAAGAGGGAT TTCATCTTTTTATTAGAAAAAAACCTGCAATCAAATCAGTAATATTGACAGAGTCTTTTGAAATT CCTGATAAGAAAAAAGATGTGGCTACTTATTCATTTCGTACATTAAGTTATAATAAGGTTAATG GAGATGAAATTCGGATTTTTAAATGGAAGAGTTATTAAGAATAAAGAACTTTTATCATTGACATC TTCCACCCCTGTTCCTAATAAAAAGTTTGGAGAAGCTTTTCATATATTGATTCCAAAAAAATTA AAATATGGATTTCCAAATTTTTCAACAAGAAGTGGTGATATTGACTTAGAAGTATTAAAAAGTA AAAAAGAGCCCTTTTGGTTTTCTATAAGATCTTTTGAGAAAAAATATAATGATTATTTGGGCAG ATATCAAGACAATGCTTATGAATTGCTTTTCAAGGATGATCAAAATCAGGGAAAAATTGAATTT AATGAATTAAAAGATACTTTTACAAAATTTTCAGATGAGGTTGTTATTGCTAATAATGGCATTG ATATTGTTGATAAAATAAACAAAATTTTAAAAAACTCAGAAGATTCAGTTTATGATTTAGATTT AGTGCTTGTTGTTGATGTTACTGATAGTATGAAAAGCAATATTGAGATTCTAAAAGAGCATTTG TTTTCAATAATAGAACCTCAACTTCAAAAGTTTAAATCCTACAGAATAGCTCTTGTTTTTTATAA AGACTATCTTGAAGATTTTTTAACCAAAGCTTTTGATTTTAATACTATTCCTTATTTAAATAATA TTCTTAAGTATGTTAATGTTGGTGGCGGTGGGGATTATCCAGAAGCTGTTTTTGAGGGGATTGA TGCTGCTGTGACCCAATTTGATTGGCGGGCAGAAAGAAGGTTTATTATTGTTATAGGAGATGCA CCTCCTCATGAGTATCCAAGAGGGTCTATTGTTTATAAAGATGTTATCAATTCTGCAAAGGAAA AAGATATTACAATTTATGGAATAATATTTCAGTAA f617.aa (SEQ ID NO:201) MIFFRNSFMALIFSFSILSISYFFGDFFQFSYIKMISWRFILFLIMATGIATCAKSNSLNLGNEGQIYFGA FLVYIFSSFFGLTYFNFVFLILLSSFFVGLLGLIPFFITFFFGLNKALTGLLISYGNQRLVDGFILNMLKT GSFSNQTKRINSLFALDSSLIYLFLLLGVSVWLFYVFIHKKTIYGLQLEILSNKKKIDIFFNINEFKYKFF AVFGSAFLNGLAGSMFVVFFRPYLVLGLTSGLGWSSLIVAVISGFNYVYVLFFSLLFSILIEFNNFLNI NYDFKYEFIGLCQSIAIFISLFLIKARKK t617.aa (SEQ ID NO:202) AKSNSLNLGNEGQIYFGAFLVYIFSSFFGLTYFNFVFLILLSSFFVGLLGLIPFFITFFFGLNKALTGLLIS YGNQRLVDGFILNMLKTGSFSNQTKRINSLFALDSSLIYLFLLGVSVWLFYVFIHKKTIYGLQLEILSN KKKIDIFFNINEFKYKFFAVFGSAFLNGLAGSMFVVFFRPYLVLGLTSGLGWSSLIVAVISGFNYVYV LFFSLLFSILIEFNNFLNINYDFKYEFIGLCQSIAIFISLFLIKARKK f617.nt (SEQ ID NO:203) ATGATCTTTTTTAGAAATAGCTTTATGGCATTAATTTTTTCTTTTTCAATATTAAGTATTAGCTAT TTTTCGGTGATTTTTTTCAATTTTCTTATATTAAAATGATATCTTGGCGCTTTATTTTATTTTTA ATTATGGCTACGGGGATTGCTACTTGTGCCAAGAGTAATTCATTAAATCTTGGGAATGAAGGTC AGATTTATTTTGGGGCATTTTTAGTTTATATATTTTCAAGTTTTTTTGGATTAACCTATTTTAATT TTGTATTTTTGATACTTTTAAGTTCTTTTTTTGTAGGACTTTTGGGGCTTATCCCCTTTTTTATTA CTTTTTCTTCGGATTAAATAAAGCCTTAACAGGTCTTTTAATATCTTATGGAAATCAAAGATTG GTGGATGGATTTATTTTAAATATGTTAAAAACAGGTAGTTTTTCTAATCAGACAAAAAGGATTA ATAGTTTGTTTGCTTTAGATTCATCACTTATTTACTTGTTTTTGCTTGGTGTATCAGTTTGGCTTT TTTATGTTTTTATTCACAAAAAAACTATTTATGGTCTTCAGCTTGAAATATTAAGCAATAAAAAA AAGATAGACATTTTTTTCAATATAAATGAATTTAAATATAAGTTTTTCGCTGTATTTGGCAGTGC TTTTTTAAATGGTCTTGCAGGTTCTATGTTTGTAGTGTTTTTTAGACCATATTTGGTTTTAGGGC TAACTTCAGGACTTGGTTGGAGTAGTCTAATTGTTGCTGTAATTTCAGGATTTAATTATGTTTAT GTATTATTTTTTAGCTTATTGTTTTCAATATTAATTGAATTTAATAATTTTCTTAATATAAATTAT GACTTTAAGTATGAATTTATTGGGCTTTGTCAATCAATTGCTATTTTTATCTCTTTATTTTTGATT AAAGCTAGGAAAAAGTAG t617.nt (SEQ ID NO:204) GCCAAGAGTAATTCATTAAATCTTGGGAATGAAGGTCAGATTTATTTTGGGGCATTTTTACTTT ATATATTTTCAAGTTTTTTTGGATTAACCTATTTTAATTTTGTATTTTTGATACTTTTAAGTTCTT TTTTTGTAGGACTTTTGGGGCTTATCCCCTTTTTTATTACTTTTTTCTTCGGATTAAATAAAGCCT TAACAGGTCTTTTAATATCTTATGGAAATCAAAGATTGGTGGATGGATTTATTTTAAATATGTT AAAAACAGGTAGTTTTTCTAATCAGACAAAAAGGATTAATAGTTTGTTTGCTTTAGATTCATCA CTTATTTACTTGTTTTTGCTTGGTGTATCAGTTTGGCTTTTTTATGTTTTTATTCACAAAAAAACT ATTTATGGTCTTCAGCTTGAAATATTAAGCAATAAAAAAAAGATAGACATTTTTTTCAATATAA ATGAATTTAAATATAAGTTTTTCGCTGTATTTGGCAGTGCTTTTTTAAATGGTCTTGCAGGTTCT ATGTTTGTAGTGTTTTTTAGACCATATTTGGTTTTAGGGCTAACTTCAGGACTTGGTTGGAGTAG TCTAATTGTTGCTGTAATTTCAGGATTTAATTATGTTTATGTATTATTTTTTAGCTTATTGTTTTC AATATTAATTGAATTTAATAATTTTCTTAATATAAATTATGACTTTAAGTATGAATTTATTGGGC TTTGTCAATCAATTGCTATTTTTATGTCTTTATTTTTGATTAAAGCTAGGAAAAAGTAG f631.aa (SEQ ID NO:205) MVVEINSLRTCYLLVLLLLVAYGLVVFYTSSFFLSLELTGNPNFLFFTRLNYLFLSFMVFLVFERISLN FLKKSIFPVLIITLFLIMATFLSPSISGAKRWIFFQGVSIQPSEIFKTSFTIYLSAYLSKFDPRKNNGISYWI KPMLIFAIFWVLIILQNDYSTAIYFAILFFIVLFVSNMAFSYVFAIVVTFLPVSAIFLMLEPYRVSRIFAF LNPYDDPSGKGYQIIASLNALKSGGILGKGLGMGEVKLGKLPEANSDFIFSVLGEELGFLGVLFAISL FFLFFYFGYFIAIHSNSRFKFFIAFISSLAIFLQSMMNILIAIGLLPPTGINLPFFSSGGSSIIVTMALSGLIS NVSKNLSNN t631.aa (SEQ ID NO:206) RISLNFLKKSIFPVLIITLFLIMATFLSPSISGAKRWIFFQGVSIQPSEIFKISFTIYLSAYLSKFDPRKNNG ISYWIKPMLIFAIFWVLIILQNDYSTAIYFAILFFIVLFVSNMAFSYVFAIVVTFLPVSAIFLMLEPYRVS RIFAFLNPYDDPSGKGYQIIASLNALKSGGILGKGLGMGEVKLGKLPEANSDFIFSVLGEELGFLGVL FAISLFFLFFYFGYFIAIHSNSRFKFFIAFISSLAIFLQSMMNILIAIGLLPPTGINLPFFSSGGSSIIVTMAL SGLISNVSKNLSNN f631.nt (SEQ ID NO:207) ATGGTTGTAGAGATAAATTCACTTAGGACATGTTATTTGCTTGTTTTGCTGCTATTGGTAGCCTA TGGCCTTGTAGTTTTTTATACTTCTTCCTTTTTTCTAAGCTTAGAATTGACAGGTAATCCAAATT TTTTATTTTTCACAAGACTTAATTATCTTTTTTTAAGTTTTATGGTTTTTCTTGTTTTTGAAAGGA TTTCTTTAAATTTTTAAAAAAATCAATATTTCCTGTATTGATTATAACTCTTTTTTTAATTATGG CAACTTTTTTATCTCCAAGTATTTCTGGAGCAAAGAGATGGATATTCTTTCAAGGTGTTAGCATT CAACCTTCTGAGATTTTTAAAATATCTTTTACTATTTATCTTTCAGCTTATTTGAGCAAGTTTGA CCCAAGAAAAAACAATGGTATTTCATACTGGATAAAGCCAATGTTGATTTTTGCAATTTTTTGG GTGTTAATAATTTTGCAAAACGATTATTCAACAGCTATTTATTTTGCCATTCTTTTTTTTATTGTT TTGTTTGTTTCTAATATGGCATTTAGCTATGTTTTTGCTATTGTGGTTACTTTTTTACCAGTTTCT GCTATATTCTTGATGCTTGAACCTTATAGGGTTTCTAGAATTTTTGCCTTTCTCAATCCTTACGA TGATCCTTCTGGCAAAGGTTACCAGATAATAGCATCTCTTAATGCTTTAAAAAGTGGAGGAATT TTAGGTAAAGGGCTGGGAATGGGAGAGGTAAAACTTGGAAAATTACCAGAGGCCAATTCGGAT TTTATTTTTTCAGTTCTTGGAGAAGAATTAGGATTTTTAGGGGTTTTGTTTGCTATAAGCTTGTT TTTTTTGTTTTTTTACTTTGGTTATTTTATAGCTATTCATTCTAATAGTAGGTTTAAATTTTTTAT TGCATTTATTTCAAGTCTTGCAATTTTTCTTCAAAGCATGATGAATATTTTAATTGCAATCGGTC TTTTGCCTCCTACAGGGATAAATTTACCATTTTTTTCATCTGGGGGATCTTCTATTATTGTTACC ATGGCATTGTCTGGCCTTATTTCAAATGTTTCAAAAAATTTAAGTAATAATTGA t631.nt (SEQ ID NO:208) AGGATTTCTTTAAATTTTTTAAAAAAATCAATATTTCCTGTATTGATTATAACTCTTTTTTTAATT ATGGCAACTTTTTTATCTCCAAGTATTTCTGGAGCAAAGAGATGGATATTCTTTCAAGGTGTTA GCATTCAACCTTCTGAGATTTTTAAAATATCTTTTACTATTTATCTTTCAGCTTATTTGAGCAAG TTTGACCCAAGAAAAAACAATGGTATTTCATACTGGATAAAGCCAATGTTGATTTTTGCAATTT TTTGGGTGTTAATAATTTTGCAAAACGATTATTCAACAGCTATTTATTTTGCCATTCTTTTTTTTA TTGTTTTGTTTGTTTCTAATATGGCATTTAGCTATGTTTTTGCTATTGTGGTTACTTTTTTACCAG TTTCTGCTATATTCTTGATGCTTGAACCTTATAGGGTTTCTAGAATTTTTGCCTTTCTCAATCCTT ACGATGATCCTTCTGGCAAAGGTTACCAGATAATAGCATCTCTTAATGCTTTAAAAAGTGGAGG AATTTTAGGTAAAGGGCTGGGAATGGGAGAGGTAAAACTTGGAAAATTACCAGAGGCCAATTC GGATTTTATTTTTTCAGTTCTTGGAGAAGAATTAGGATTTTTAGGGGTTTTGTTTGCTATAAGCT TGTTTTTTTTGTTTTTTTACTTTGGTTATTTTATAGCTATTCATTCTAATAGTAGGTTTAAATTTT TTATTGCATTTATTTCAAGTCTTGCAATTTTTCTTCAAAGCATGATGAATATTTTAATTGCAATC GGTCTTTTGCCTCCTACAGGGATAAATTTACCATTTTTTTCATCTGGGGGATCTTCTATTATTGT TACCATGGCATTGTCTGGCCTTATTTCAAATGTTTCAAAAAATTTAAGTAATAATTGA f647.aa (SEQ ID NO:209) MKVNNFLSFFFRAFFLLFLIVILFFFVLFFIDFIGMYNTKRYFPEFVRTKLLGETSLVFDHNSNIILDEA RLVKEREAIDIKNQQIEKLKEDLKLKEDSLNKLEFELKQKQKDLDLKQKIIDDIINKYNDEEANILQT AVYLMNMPPEDAVKRLEDLNPELAISYMRKIEELSKKEGRLSIVPYWLSLMDSKKAAILIRKMSVSS LE t647.aa (SEQ ID NO:210) IDFIGMYNTKRYFPEFVRTKLLGETSLVFDHNSNIILDEARLVKEREAIDIKNQQIEKLKEDLKLKEDS LNKLEFELKQKQKDLDLKQKIIDDIINKYNDEEANILQTAVYLMNMPPEDAVKRLEDLNPELAISYM RKIEELSKKEGRLSIVPYWLSLMDSKKAAILIRKMSVSSLE f647.nt (SEQ ID NO:211) ATGAAAGTGAATAATTTTTTATCGTTCTTTTTTAGGGCATTTTTTTTGTTATTTTTAATTGTTATT TTATTTTTCTTTGTATTATTCTTTATTGATTTTATTGGAATGTATAATACTAAAAGATATTTCCCC GAATTTGTAAGAACCAAGTTGTTAGGAGAAACTTCTCTGGTCTTTGATCATAATTCTAATATAA TTCTTGATGAAGCTAGACTTGTGAAGGAAAGAGAAGCTATTGATATTAAGAATCAGCAGATTG AAAAGCTTAAAGAAGATCTAAAGTTAAAAGAAGACAGTTTAAATAAGCTTGAATTTGAGCTTA AGCAAAAGCAGAAAGATTTAGATTTAAAACAAAAAATAATAGATGACATTATAAATAAATATA ATGATGAGGAAGCAAATATTTTGCAAACAGCTGTATATTTAATGAATATGCCACCAGAAGATGC TGTTAAGCGGCTTGAAGATTTAAATCCCGAGCTTGCAATATCTTATATGCGGAAAATTGAAGAG CTTTCCAAAAAAGAAGGTCGTTTATCAATTGTTCCTTATTGGTTATCTCTTATGGATTCTAAAAA AGCTGCTATATTGATTAGAAAAATGTCTGTTAGTTCATTGGAGTAG t647.nt (SEQ ID NO:212) ATTGATTTTATTGGAATGTATAATACTAAAAGATATTTCCCCGAATTTGTAAGAACCAAGTTGT TAGGAGAAACTTCTCTGGTCTTTGATCATAATTCTAATATAATTCTTGATGAAGCTAGACTTGTG AAGGAAAGAGAAGCTATTGATATTAAGAATCAGCAGATTGAAAAGCTTAAAGAAGATCTAAAG TTAAAAGAAGACAGTTTAAATAAGCTTGAATTTGAGCTTAAGCAAAAGCAGAAAGATTTAGAT TTAAAACAAAAAATAATAGATGACATTATAAATAAATATAATGATGAGGAAGCAAATATTTTG CAAACAGCTGTATATTTAATGAATATGCCACCAGAAGATGCTGTTAAGCGGCTTGAAGATTTAA ATCCCGAGCTTGCAATATCTTATATGCGGAAAATTGAAGAGCTTTCCAAAAAAGAAGGTCGTTT ATCAATTGTTCCTTATTGGTTATCTCTTATGGATTCTAAAAAAGCTGCTATATTGATTAGAAAAA TGTCTGTTAGTTCATTGGAGTAG f653.aa (SEQ ID NO:213) MLTYGDMVTLLLVFFVTMFSLNDIIFQENVIRIMSASFTGAGFFKGGKTLDFSKLSYLSNSFMSLPST VRNKQASQTAKNKSMIEFIEKIQSKNIVVRQEERGIVISLAADAFFDSASADVKLEENRDSIQKIASFI GFLSPRGYNFKIEGHTDNIDTDVNGPWKSNWELSAARSVNMLEHILNYLDQSDVKRIENNFEVSGF GGSRPIATDDTPEGRAYNRRIDILITTDASLSTPKEIKQ t653.aa (SEQ ID NO:214) NDIIFQENVIRIMSASFTGAGFFKGGKTLDFSKLSYLSNSFMSLPSTVRNKQASQTAKNKSMIEFIEKI QSKNIVVRQEERGIVISLAADAFFDSASADVKLEENRDSIQKIASFIGFLSPRGYNFKIEGHTDNIDTD VNGPWKSNWELSAARSVNMLEHILNYLDQSDVKRIENNFEVSGFGGSRPIATDDTPEGRAYNRRIDI LITTDASLSFPKEIKQ f653.nt (SEQ ID NO:215) ATGTTGACTTATGGAGACATGGTTACTTTGCTGCTTGTGTTTTTTGTTACAATGTTTTCATTAAA TGATATTATTTTTCAAGAAAATGTGATAAGAATAATGTCTGCTTCTTTCACGGGTGCTGGATTTT TCAAGGGCGGTAAAACTTTAGATTTTAGTAAATTATCTTATTTGAGTAATAGCTTTATGTCTTTG CCTTCTACTGTGCGCAATAAACAAGCATCTCAGACTGCTAAAAATAAATCCATGATTGAATTTA TTGAGAAGATTCAGTCTAAAAATATTGTAGTTAGGCAAGAAGAAAGAGGTATTGTAATATCTCT TGCAGCAGATGCATTTTTTGATTCTGCTAGTGCAGATGTTAAGCTTGAAGAGAATAGAGATTCT ATTCAAAAAATAGCATCTTTTATTGGCTTTTTAAGTCCTAGAGGCTATAATTTTAAAATAGAAG GGCATACAGATAATATTGATACTGATGTAAATGGACCTTGGAAAAGCAATTGGGAACTTTCGGC TGCTAGATCTGTTAATATGCTGGAACATATTTTGAACTATTTAGATCAATCTGATGTTAAAAGA ATTGAAAATAATTTTGAAGTATCTGGTTTTGGTGGAAGTAGGCCTATTGCAACAGACGATACCC CTGAGGGTAGGGCTTATAATAGAAGAATTGATATATTAATTACTACAGATGCATCTTTAAGTTT CCCTAAGGAAATTAAGCAGTAA t653.nt (SEQ ID NO:216) AATGATATTATTTTTCAAGAAAATGTGATAAGAATAATGTCTGCTTCTTTCACGGGTGC TGGATTTTTCAAGGGCGGTAAAACTTTAGATTTTAGTAAATTATCTTATTTGAGTAATAGCTTTA TGTCTTTGCCTTCTACTGTGCGCAATAAACAAGCATCTCAGACTGCTAAAAATAAATCCATGAT TGAATTTATTGAGAAGATTCAGTCTAAAAATATTGTAGTTAGGCAAGAAGAAAGAGGTATTGTA ATATCTCTTGCAGCAGATGCATTTTTTGATTCTGCTAGTGCAGATGTTAAGCTTGAAGAGAATA GAGATTCTATTCAAAAAATAGCATCTTTTATTGGCTTTTTAAGTCCTAGAGGCTATAATTTTAAA ATAGAAGGGCATACAGATAATATTGATACTGATGTAAATGGACCTTGGAAAAGCAATTGGGAA CTTTCGGCTGCTAGATCTGTTAATATGCTGGAACATATTTTGAACTATTTAGATCAATCTGATGT TAAAAGAATTGAAAATAATTTTGAAGTATCTGGTTTTGGTGGAAGTAGGCCTATTGCAACAGAC GATACCCCTGAGGGTAGGGCTTATAATAGAAGAATTGATATATTAATTACTACAGATGCATCTT TAAGTTTCCCTAAGGAAATTAAGCAGTAA f664.aa (SEQ ID NO:217) MRMSVYTMGFAYIRSIMGYVVLFFFASLAVNFFVNIIQVGFFITFKSLEPRWDKISFNFSRWAKNSFF SAGAFFNLFKSLLKVVIICLIYYFIIENNIGKISKLSEYTLQSGISIVLVIAYKICFFSVMFLAIVGVFDYL FQRSQYIESLKMTKEEVKQERKEMEGDPLLRSRIKERMRVILSTNLRVAIPQADVVITNPEHFAVAIK WDSETMLAPKVLAKGQDEIALTIKKIARENNVPLMENKLLARALYANVKVNEEIPREYWEIVSKILV RVYSITKKFN t664.aa (SEQ ID NO:218) FVNIIQVGFFITFKSLEPRWDKISFNFSRWAKNSFFSAGAFFNLFKSLLKVVIICLIYYFIIENNIGKISKL SEYTLQSGISIVLVIAYKICFFSVMFLAIVGVFDYLFQRSQYIESLKMTKEEVKQERKEMEGDPLLRSR IKERMRVILSTNTLRVAIPQADVVITNPEHFAVAIKWDSETMLAPKVLAKGQDEIALTIKKIARENNVP LMENKLLARALYANVKVNEEIPREYWEIVSKILVRVYSITKKFN f664.nt (SEQ ID NO:219) ATGCGTATGAGTGTTTATACTATGGGTTTTGCATATATTAGATCTATCATGGGGTATGTCGTTTT GTTTTTTTTCGCATCTTTAGCTGTTAATTTTTTTGTTAATATTATTCAAGTAGGCTTTTTTATTAC TTTTAAATCTTTGGAGCCAAGGTGGGATAAAATTAGTTTTAATTTTTCCAGATGGGCAAAAAAT TCTTTTTTTTCAGCAGGGGCTTTTTTCAATTTGTTTAAAAGTTTGTTAAAAGTTGTTATAATATG CTTGATATATTATTTTATTATAGAAAACAATATAGGCAAAATTTCTAAGCTTTCGGAGTATACA CTTCAATCTGGAATTTCTATTGTGTTAGTGATTGCCTATAAGATATGTTTTTTTTCAGTAATGTT TTTGGCAATTGTAGGGGTGTTTGATTATTTGTTTCAAAGATCTCAGTACATTGAGAGTTTGAAA ATGACAAAAGAAGAGGTAAAGCAGGAAAGAAAGGAAATGGAAGGTGATCCTTTACTTCGATCT AGAATAAAAGAGAGAATGAGGGTTATTTTAAGTACCAATTTAAGAGTAGCTATTCCTCAAGCA GATGTAGTAATTACAAATCCAGAACATTTTGCAGTTGCTATTAAATGGGATAGCGAAACAATGT TAGCTCCAAAGGTGCTTGCAAAAGGTCAAGATGAAATAGCTCTCACAATTAAAAAAATTGCAA GAGAAAATAATGTTCCTTTAATGGAAAATAAGCTCCTTGCAAGAGCTCTTTATGCTAATGTTAA GGTTAATGAAGAGATTCCAAGAGAATATTGGGAGATTGTTTCAAAAATTCTTGTGAGAGTATAT TCTATTACTAAAAAGTTTAATTAG t664.nt (SEQ ID NO:220) TTTGTTAATATTATTCAAGTAGGCTTTTTTATTACTTTTAAATCTTTGGAGCCAAGGTGGGATAA AATTAGTTTTAATTTTTCCAGATGGGCAAAAAATTCTTTTTTTTCAGCAGGGGCTTTTTTCAATT TGTTTAAAAGTTTGTTAAAAGTTGTTATAATATGCTTGATATATTATTTTATTATAGAAAACAAT ATAGGCAAAATTTCTAAGCTTTCGGAGTATACACTTCAATCTGGAATTTCTATTGTGTTAGTGAT TGCCTATAAGATATGTTTTTTTTCAGTAATGTTTTTGGCAATTGTAGGGGTGTTTGATTATTTGT TTCAAAGATCTCAGTACATTGAGAGTTTGAAAATGACAAAAGAAGAGGTAAAGCAGGAAAGAA AGGAAATGGAAGGTGATCCTTTACTTCGATCTAGAATAAAAGAGAGAATGAGGGTTATTTTAA GTACCAATTTAAGAGTAGCTATTCCTCAAGCAGATGTAGTAATTACAAATCCAGAACATTTTGC AGTTGCTATTAAATGGGATAGCGAAACAATGTTAGCTCCAAAGGTGCTTGCAAAAGGTCAAGA TGAAATAGCTCTCACAATTAAAAAAATTGCAAGAGAAAATAATGTTCCTTTAATGGAAAATAAG CTCCTTGCAAGAGCTCTTTATGCTAATGTTAAGGTTAATGAAGAGATTCCAAGAGAATATTGGG AGATTGTTTCAAAAATTCTTGTGAGAGTATATTCTATTACTAAAAAGTTTAATTAG f680.aa (SEQ ID NO:221) MFTLSFVLINFIITGILILMLEFNFLKVDFKGNILLAGIFMGLMQGLGALPGISRSGITIFSASVTGFNRK SAFEISFLSLIPIVFGAILLKHKEFYDIFMVLNFFEINLGALVAFVVGIFSINFFFKMLNNKKLYYFSIYL FALSIIVCYFVRI t680.aa (SEQ ID NO:222) ITGILILMLEFNFLKVDFKGNILLAGIFMGLMQGLGALPGISRSGITIFSASVIGFNRKSAFEISFLSLIPI VFGAILLKHKEFYDIFMVLNFFEINLGALVAFVVGIFSINFFFKMLNNKKLYYFSIYLFALSIIVCYFVR I f680.nt (SEQ ID NO:223) ATGTTTACATTGTCTTTCGTTTTAATTAATTTTATTATAACAGGGATTTTAATCTTGATGCTAGA ATTTAATTTTTTAAAAGTTGATTTTAAAGGTAATATTTTGTTAGCAGGAATTTTTATGGGGCTGA TGCAAGGCTTGGGTGCGCTTCCAGGAATCTCTCGTTCAGGAATTACGATCTTTTCGGCATCGGT TATTGGATTTAATAGAAAAAGTGCATTTGAAATTTCATTTTTATCTTTAATTCCAATAGTTTTTG GAGCGATTTTATTAAAACATAAAGAATTTTATGATATTTTTATGGTTTTAAATTTTTTTGAAATA AACTTAGGAGCATTAGTTGCTTTTGTTGTTGGTATTTTCTCAATAAATTTCTTTTTTAAAATGCT TAATAACAAAAAACTGTATTATTTTTCTATATATTTATTTGCACTTTCAATTATAGTTTGTTATTT TGTTAGAATATGA t680.nt (SEQ ID NO:224) ATAACAGGGATTTTAATCTTGATGCTAGAATTTAATTTTTTAAAAGTTGATTTTAAAGGTAATAT TTTGTTAGCAGGAATTTTTATGGGGCTGATGCAAGGCTTGGGTGCGCTTCCAGGAATCTCTCGT TCAGGAATTACGATCTTTTCGGCATCGGTTATTGGATTTAATAGAAAAAGTGCATTTGAAATTT CATTTTTATCTTTAATTCCAATAGTTTTTGGAGCGATTTTATTAAAACATAAAGAATTTTATGAT ATTTTTATGGTTTTAAATTTTTTTGAAATAAACTTAGGAGCATTAGTTGCTTTTGTTGTTGGTAT TTTCTCAATAAATTTCTTTTTTAAAATGCTTAATAACAAAAAACTGTATTATTTTTCTATATATTT ATTTGCACTTTCAATTATAGTTTGTTATTTTGTTAGAATATGA f688.aa (SEQ ID NO:225) MIVLLISIGCANAVHIINEIFKLIKKEQLSKESIKATIKKLKTPILLTSFTTAFGFLSLTTSSINAYKTMGI FMSIGVIISMIISLTVLPGIITLIPFAKKKSFEKEKENKLNKISFLERLAKLNTQITKSILKRKYTSSIMVLI ILGISFVGLLKIEINFDEKDYFKESTSVKKTLNLMQKEMGGISIFKIEIEGRPGEFKNAKAMQILDLITD KLDAFSAKTQSSSINGILKFTNFKIKKESPLEYKLPENKIILNKLINLIDKSDWTKDNKRMYINDDWSL ISIIVRIEDNSTEGIKKFEKYAINTINEYMKNNKYHFSGVYDKVLIAKTMVKEQVINIITTLGSITLLLM FFFKSIKTGIIIAIPVAWSVFLNFAVMRLFGITLNPATATIASVSMGVGVDYSIHFFNTFILQYQKNQIY KTALLESIPNVFNGIFANSISVGIGFLTLTFSSYKIISTLGAIIAFTMLTTSLASLTLLPLLIYLFKPRVKL ASNNNFKKLKQ t688.aa (SEQ ID NO:226) YKTMGIFMSIGVIISMIISLTVLPGIITLIPFAKKKSFEKEKENKLNKISFLERLAKLNTQITKSILKRKYT SSIMVLIILGISFVGLLKIEINFDEKDYFKESTSVKKTLNLMQKEMGGISIFKIEIEGRPGEFKNAKAMQ ILDLITDKLDAFSAKTQSSSINGILKFTNFKIKKESPLEYKLPENKIILNKLINLIDKSDWTKDNKRMYI NDDWSLISIIVRIEDNSTEGIKKFEKYAINTINEYMKNNKYHFSGVYDKVLIAKTMVKEQVINIITTLG SITLLLMFFFKSIKTGIIIAIPVAWSVFLNFAVMRLFGITLNPATATIASVSMGVGVDYSIHFFNTFILQY QKNQIYKTALLESIPNVFNGIFANSISVGIGFLTLTFSSYKIISTLGAIIAFTMLTTSLASLTLLPLLIYLF KPRVKLASNNNFKKLKQ f688.nt (SEQ ID NO:227) ATGATTGTTTTACTTATTTCAATCGGATGCGCCAATGCTGTACATATAATAAATGAAATATTTAA ATTAATAAAAAAAGAACAGCTCTCAAAAGAATCCATAAAAGCAACAATTAAAAAACTTAAAAC ACCCATCCTGCTAACATCTTTTACAACTGCATTTGGATTTTTATCTCTTACAACCTCTTCAATTA ATGCCTACAAAACAATGGGTATTTTCATGTCAATTGGAGTAATTATCTCAATGATAATCTCATT AACCGTTTTACCTGGAATAATAACATTAATCCCATTTGCAAAAAAAAAGTCTTTTGAAAAAGAA AAAGAAAATAAACTAAATAAAATATCCTTCCTTGAAAGACTTGCCAAACTAAATACGCAAATAA CAAAATCTATATTAAAAAGAAAATATACATCCTCTATAATGGTCCTCATCATACTGGGAATTTC TTTTGTAGGTCTTTTAAAAATCGAAATCAATTTTGATGAAAAAGATTACTTTAAAGAAAGCACA AGTGTAAAAAAAACATTAAACCTAATGCAAAAAGAAATGGGGGGAATATCGATTTTCAAAATA GAAATTGAAGGCAGGCCCGGTGAATTTAAAAATGCTAAAGCAATGCAAATATTAGACTTAATT ACAGATAAGCTTGATGCATTTTCTGCAAAAACTCAATCTAGTTCTATTAATGGCATTTTAAAATT TACAAATTTTAAAATTAAAAAAGAATCCCCACTAGAGTATAAACTGCCTGAAAATAAAATTATA CTAAACAAACTAATAAATTTGATAGATAAAAGCGATTGGACTAAGGACAATAAAAGAATGTAC ATTAACGATGACTGGTCATTAATATCTATCATAGTAAGAATTGAAGACAACTCAACCGAAGGAA TAAAAAAATTTGAAAAATATGCTATTAACACAATTAATGAATATATGAAAAATAATAAATATCA TTTCTCAGGTGTTTATGATAAGGTATTAATAGCTAAAACAATGGTAAAAGAACAGGTTATAAAC ATTATAACAACTCTTGGATCAATAACACTACTACTTATGTTTTTCTTTAAATCTATAAAAACCGG AATAATTATTGCAATCCCAGTAGCATGGTCAGTGTTTTTAAACTTTGCTGTAATGAGATTATTTG GGATAACCTTAAACCCCGCAACGGCAACAATTGCATCTGTAAGCATGGGAGTAGGAGTAGATT ATTCAATTCATTTTTTCAATACATTTATTTTACAATACCAAAAAAATCAAATCTACAAAACTGCA CTTCTTGAATCAATACCCAATGTATTTAATGGAATATTTGCAAATTCTATTTCTGTTGGAATAGG ATTTTTAACTCTAACATTTTCGTCTTATAAAATAATATCAACTCTTGGAGCAATAATTGCTTTTA CAATGCTAACGACATCTCTTGCATCACTAACTCTTCTTCCATTATTAATTTATTTATTTAAACCT AGAGTAAAGCTAGCCTCAAACAACAATTTTAAAAAATTAAAACAATAA t688.nt (SEQ ID NO:228) TACAAAACAATGGGTATTTTCATGTCAATTGGAGTAATTATCTCAATGATAATCTCATTAACCG TTTTACCTGGAATAATAACATTAATCCCATTTGCAAAAAAAAAGTCTTTTGAAAAAGAAAAAGA AAATAAACTAAATAAAATATCCTTCCTTGAAAGACTTGCCAAACTAAATACGCAAATAACAAAA TCTATATTAAAAAGAAAATATACATCCTCTATAATGGTCCTCATCATACTGGGAATTTCTTTTGT AGGTCTTTTAAAAATCGAAATCAATTTTGATGAAAAAGATTACTTTAAAGAAAGCACAAGTGTA AAAAAAACATTAAACCTAATGCAAAAAGAAATGGGGGGAATATCGATTTTCAAAATAGAAATT GAAGGCAGGCCCGGTGAATTTAAAAATGCTAAAGCAATGCAAATATTAGACTTAATTACAGAT AAGCTTGATGCATTTTCTGCAAAAACTCAATCTAGTTCTATTAATGGCATTTTAAAATTTACAAA TTTTAAAATTAAAAAAGAATCCCCACTAGAGTATAAACTGCCTGAAAATAAAATTATACTAAAC AAACTAATAAATTTGATAGATAAAAGCGATTGGACTAAGGACAATAAAAGAATGTACATTAAC GATGACTGGTCATTAATATCTATCATAGTAAGAATTGAAGACAACTCAACCGAAGGAATAAAA AAATTTGAAAAATATGCTATTAACACAATTAATGAATATATGAAAAATAATAAATATCATTTCT CAGGTGTTTATGATAAGGTATTAATAGCTAAAACAATGGTAAAAGAACAGGTTATAAACATTAT AACAACTCTTGGATCAATAACACTACTACTTATGTTTTTCTTTAAATCTATAAAAACCGGAATAA TTATTGCAATCCCAGTAGCATGGTCAGTGTTTTTAAACTTTGCTGTAATGAGATTATTTGGGATA ACCTTAAACCCCGCAACGGCAACAATTGCATCTGTAAGCATGGGAGTAGGAGTAGATTATTCAA TTCATTTTTTCAATACATTTATTTTACAATACCAAAAAAATCAAATCTACAAAACTGCACTTCTT GAATCAATACCCAATGTATTTAATGGAATATTTGCAAATTCTATTTCTGTTGGAATAGGATTTTT AACTCTAACATTTTCGTCTTATAAAATAATATCAACTCTTGGAGCAATAATTGCTTTTACAATGC TAACGACATCTCTTGCATCACTAACTCTTCTTCCATTATTAATTTATTTATTTAAACCTAGAGTA AAGCTAGCCTCAAACAACAATTTTAAAAAATTAAAACAATAA f704.aa (SEQ ID NO:229) MNYTKFQEFISEFLGTFILLALGTGSVAMTVLFSSSPEIPGEIIKGGYTNIVFGWGLGVTFGIYTAARM SGAHLNPAVSIGLASVGKFPVSKLLHYIVAQILGAFTGALMTLVVFYPKWIEMDPGLENTQGIMATF PAVPGFLPGFIDQIFGTFLLMFLISVVGDFTKKHSDNPFIPFIVGAVVLSIGISFGGMNGYAINPARDLG PRILLLFAGFKNHGFNNLSIVIVPIIGPIIGAILGATIYEFTLKNNKD t704.aa (SEQ ID NO:230) GEIIKGGYTNIVFGWGLGVTFGIYTAARMSGAHLNPAVSIGLASVGKFPVSKLLHYIVAQIL GAFTGALMTLVVFYPKWIEMDPGLENTQGIMATFPAVPGFLPGFIDQIFGTFLLMFLISVVGDFTKK HSDNPFIPFIVGAVVLSIGISFGGMNGYAINPARDLGPRILLLFAGFKNHGFNNLSIVIVPIIGPIIGAILG ATIYEFTLKNNKD f704.nt (SEQ ID NO:231) ATGAATTATACAAAATTCCAAGAATTTATATCGGAATTTTTGGGAACATTTATCCTATTGGCTCT AGGAACTGGATCTGTTGCAATGACAGTATTATTTTCCTCAAGTCCCGAAATACCAGGAGAAATA ATAAAAGGAGGATATACAAATATAGTATTTGGATGGGGATTGGGTGTAACGTTTGGTATTTACA CAGCAGCAAGAATGAGCGGAGCACACCTAAACCCAGCTGTTAGCATAGGATTAGCAAGTGTTG GAAAGTTTCCCGTTTCAAAACTTTTACATTACATTGTAGCACAAATATTAGGAGCTTTTACAGG TGCATTAATGACACTTGTCGTATTTTATCCTAAATGGATAGAAATGGATCCTGGCTTAGAAAAT ACTCAAGGAATAATGGCAACTTTCCCTGCTGTTCCTGGATTTTTGCCTGGATTTATTGATCAAAT TTTTGGAACTTTTTTGCTAATGTTTTTAATTTCTGTTGTTGGAGATTTTACAAAAAAACACAGCG ACAATCCATTTATTCCTTTTATTGTAGGAGCAGTGGTTTTATCAATAGGGATAAGTTTCGGAGG AATGAACGGTTATGCTATTAATCCTGCAAGGGATCTGGGACCAAGAATTTTACTCTTATTTGCT GGATTTAAAAATCACGGATTTAACAATCTAAGTATAGTTATTGTACCAATAATTGGCCCAATAA TTGGAGCAATTTTGGGAGCTACAATTTACGAATTTACACTAAAAAATAACAAAGACTAA t704.nt (SEQ ID NO:232) GGAGAAATAATAAAAGGAGGATATACAAATATAGTATTTGGATGGGGATTGGGTGTAACGTTT GGTATTTACACAGCAGCAAGAATGAGCGGAGCACACCTAAACCCAGCTGTTAGCATAGGATTA GCAAGTGTTGGAAAGTTTCCCGTTTCAAAACTTTTACATTACATTGTAGCACAAATATTAGGAG CTTTTACAGGTGCATTAATGACACTTGTCGTATTTTATCCTAAATGGATAGAAATGGATCCTGG CTTAGAAAATACTCAAGGAATAATGGCAACTTTCCCTGCTGTTCCTGGATTTTTGCCTGGATTTA TTGATCAAATTTTTGGAACTTTTTTGCTAATGTTTTTAATTTCTGTTGTTGGAGATTTTACAAAA AAACACAGCGACAATCCATTTATTCCTTTTATTGTAGGAGCAGTGGTTTTATCAATAGGGATAA GTTTCGGAGGAATGAACGGTTATGCTATTAATCCTGCAAGGGATCTGGGACCAAGAATTTTACT CTTATTTGCTGGATTTAAAAATCACGGATTTAACAATCTAAGTATAGTTATTGTACCAATAATTG GCCCAATAATTGGAGCAATTTTGGGAGCTACAATTTACGAATTTACACTAAAAAATAACAAAG ACTAA f707.aa (SEQ ID NO:233) MRRLFLLYILCSFVFLNLFAQGSSSYIDKQKELAIFYYEVGQRYINVGKIKKGKLFQAKALKIYPDLK KGFDIKLAVKELDARIKDDNPKVVMLEDIKLEEIPGIVHEKIEINDFTNAPKIEYIAQRERSKNQDKII KFQFGKFARALISRNFDLFDSVIADKVNVMGQFESKNDFISTLSSASSKADADELEYLSVDDYYDLK SLKISKSNDTSFAVNVNAKKNDVTKNFPFWKERQTLIFTTEDDNNWFLSSIN t707.aa (SEQ ID NO:234) MRRLFLLYILCSFVFLNLFAQGSSSYIDKQKELAIFYYEVGQRYINVGKIKKGKLFQAKALKIYPDLK KGFDIKLAVKELDARIKDDNPKVVMLEDIKLEEIPGIVHEKIEINDFTNAPKIEYIAQRERSKNQDKII KFQFGKFARALISRNFDLFDSVIADKVNVMGQFESKNDFISTLSSASSKADADELEYLSVDDYYDLK SLKISKSNDTSFAVNVNAKKNDVTKNFPFWKERQTLIFTTEDDNNWFLSSIN f707.nt (SEQ ID NO:235) ATGAGAAGATTATTTCTTCTATATATTTTATGTTCTTTTGTTTTTTTGAATTTATTTGCTC AAGGTAGTTCTTCTTATATTGATAAGCAAAAAGAGCCTGCTATTTTTTATTATGAGGTTGGTCA AAGATATATAAACGTTGGTAAAATTAAAAAAGGAAAGCTTTTTCAAGCAAAAGCTTTAAAGAT TTATCCAGATTTGAAAAAGGGGTTTGATATCAAGCTTGCAGTTAAAGAGCTTGATGCTAGGATT AAAGATGACAATCCCAAGGTTGTTATGCTTGAGGATATTAAGCTTGAGGAGATACCTGGAATA GTGCACGAAAAAATAGAAATCAATGATTTTACAAATGCTCCTAAAATAGAATATATTGCTCAAA GAGAGAGAAGCAAAAATCAAGATAAAATTATTAAGTTTCAATTTGGAAAGTTTGCAAGAGCTT TAATTTCTAGGAACTTTGATTTGTTTGATTCAGTTATTGCGGATAAAGTTAACGTTATGGGTCAA TTTGAATCAAAAAATGATTTTATATCAACTTTATCAAGTGCTTCATCTAAGGCCGATGCTGATG AGTTAGAGTATTTATCAGTTGATGATTATTACGATTTAAAGTCTTTAAAAATTTCAAAATCCAA CGATACTTCTTTTGCTGTTAATGTTAATGCCAAAAAAAATGATGTTACTAAAAATTTTCCATTTT GGAAAGAACGTCAAACTTTAATTTTTACTACAGAGGATGATAATAATTGGTTTTTGTCTTCCAT AAATTGA t707.nt (SEQ ID NO:236) CAAGGTAGTTCTTCTTATATTGATAAGCAAAAAGAGCTTGCTATTTTTTATTATGAGGTTGGTCA AAGATATATAAACGTTGGTAAAATTAAAAAAGGAAAGCTTTTTCAAGCAAAAGCTTTAAAGAT TTATCCAGATTTGAAAAAGGGGTTTGATATCAAGCTTGCAGTTAAAGAGCTTGATGCTAGGATT AAAGATGACAATCCCAAGGTTGTTATGCTTGAGGATATTAAGCTTGAGGAGATACCTGGAATA GTGCACGAAAAAATAGAAATCAATGATTTTACAAATGCTCCTAAAATAGAATATATTGCTCAAA GAGAGAGAAGCAAAAATCAAGATAAAATTATTAAGTTTCAATTTGGAAAGTTTGCAAGAGCTT TAATTTCTAGGAACTTTGATTTGTTTGATTCAGTTATTGCGGATAAAGTTAACGTTATGGGTCAA TTTGAATCAAAAAATGATTTTATATCAACTTTATCAAGTGCTTCATCTAAGGCCGATGCTGATG AGTTAGAGTATTTATCAGTTGATGATTATTACGATTTAAAGTCTTTAAAAATTTCAAAATCCAA CGATACTTCTTTTGCTGTTAATGTTAATGCCAAAAAAAATGATGTTACTAAAAATTTTCCATTTT GGAAAGAACGTCAAACTTTAATTTTTACTACAGAGGATGATAATAATTGGTTTTTGTCTTCCAT AAATTGA f709.aa (SEQ ID NO:237) MLIFGFIGLFFLNIFSLHAQGIVTNKDAQEEFKWALNSYNNGIYDDALLSFKKILSFDPNNLDYHFWT GNVYYRLGYVEEALMEWRNLKDQGYKVPYLRHLISTIEQRRGIFSNYELNFKKLVKVASLDNSIYK RPHGYQITSLRADKYGGYYAANFVGNEILYFDVNNNVNALVKDGFSYLKSPYDVIEANNLLYVTLY SSDEIGVYDKVLGVKRKSIGNKGTKDGELLAPQYMAIDKRNYIYVSEWGNKRVSKFGLEGDFILHF GSRTSGYKGLLGPTGVTYLNENIYVADSLRNTIEVFDTSGNHLYSVFTSIEGIEGLSSDFVGNNVIVSS KDGVYKYSIAKKTITKILKADKMNSKISSSILDANNQMIVSDFNNAKVSVYKSDASLYDSLNVDVRR IIRLGGPKIYVELNVSSKSGLPVVGLKSENFSISNENYYIVNPKVAYNVNASKDINIAVVFDKSSYMK KYDTDQIVGLNALMELSKNKNFSFINATSVPIIDNIESLTNSIRNTSSLGPYSTDAVKTDVSLKLAGSG LMSKSSRRAVVYFSGGILNRKAFEKYSLDTIVSYYKNNDIRFYLILFGNDPINSKLQYLVNETGGAVI PFSSYEGVSKVYDLILEQKTGTYLLEYYYPGPQEPNKYFNLSVEANINQQTGRGEFAYFIN t709.aa (SEQ ID NO:238) QGIVTNKDAQEEFKWALNSYNNGIYDDALLSFKKILSFDPNNLDYHFWTGNVYYRLGYVEEALME WRNLKDQGYKVPYLRHLISTIEQRRGIFSNYELNFKKLVKVASLDNSIYKRPHGYQITSLRADKYGG YYAANFVGNEILYFDVNNNVNALVKDGFSYLKSPYDVIEANNLLYVTLYSSDEIGVYDKVLGVKRK SIGNKGTKDGELLAPQYMAIDKRNYIYVSEWGNKRVSKFGLEGDFILHFGSRTSGYKGLLGPTGVT YLNENIYVADSLRNTIEVFDTSGNHLYSVFTSIEGIEGLSSDFVGNNVIVSSKDGVYKYSIAKKTITKI LKADKMNSKISSSILDANNQMIVSDFNNAKVSVYKSDASLYDSLNVDVRRIIRLGGPKIYVELNVSS KSGLPVVGLKSENFSISNENYYIVNPKVAYNVNASKDINIAVVFDKSSYMKKYDTDQIVGLNALME LSKNKNFSFINATSVPIIDNIESLTNSIRNTSSLGPYSTDAVKTDVSLKLAGSGLMSKSSRRAVVYFSG GILNRKAFEKYSLDTIVSYYKNNDIRFYLILFGNDPINSKLQYLVNETGGAVIPFSSYEGVSKVYDLIL EQKTGTYLLEYYYPGPQEPNKYFNLSVEANINQQTGRGEFAYFIN f709.nt (SEQ ID NO:239) ATGTTAATTTTTGGTTTTATTGGTTTGTTTTTTTTAAATATTTTTAGTTTGCATGCCCAAGGAATA GTTACTAATAAAGATGCTCAAGAAGAGTTTAAATGGGCTCTTAATTCTTATAATAATGGAATTT ACGATGATGCTCTTTTATCTTTTAAAAAAATTTTAAGCTTTGATCCTAATAATCTTGATTATCAT TTTTGGACTGGCAATGTTTATTATAGACTGGGTTATGTTGAAGAAGCTTTAATGGAATGGAGAA ATTTAAAAGATCAAGGCTATAAGGTTCCCTATCTTAGACATTTGATTTCTACTATTGAGCAAAG GAGAGGTATTTTTTCAAATTATGAACTTAATTTTAAAAAACTTGTAAAAGTTGCTTCTCTTGATA ATTCTATTTATAAAAGGCCACATGGGTACCAGATTACATCTTTAAGGGCTGATAAGTACGGCGG ATATTACGCTGCTAACTTTGTAGGCAATGAAATATTGTATTTTGATGTTAATAACAATGTTAAT GCTTTAGTTAAAGATGGCTTTAGTTATTTAAAATCACCTTATGATGTTATTGAAGCTAATAATCT GCTTTATGTGACTCTTTATTCAAGTGATGAAATTGGTGTTTATGACAAAGTTCTTGGAGTTAAA AGGAAATCTATTGGGAATAAAGGCACAAAAGATGGCGAATTGCTTGCTCCTCAGTATATGGCT ATTGATAAGAGAAACTATATTTATGTAAGTGAGTGGGGAAATAAAAGAGTAAGTAAATTTGGA CTTGAAGGTGATTTTATTTTGCATTTTGGTTCTAGAACTTCAGGCTATAAGGGCCTTTTAGGTCC CACAGGCGTTACTTATTTGAATGAAAACATTTATGTTGCAGATTCTCTGAGAAATACCATTGAA GTTTTTTGATACTAGTGGTAATCATTTATATTCAGTTTTTACTTCTATTGAGGGAATAGAGGGGCT TAGCAGTGATTTTGTAGGTAATAATGTTATAGTATCCTCAAAAGATGGTGTTTATAAATATAGC ATTGCTAAAAAGACAATTACAAAAATTTTAAAAGCAGATAAAATGAATTCTAAAATTTCTTCAT CTATTTTGGATGCCAATAATCAGATGATTGTCTCAGATTTTAATAATGCCAAGGTTTCAGTTTAC AAGAGTGATGCAAGCCTTTATGATAGTTTAAATGTTGATGTTAGAAGAATAATTAGGCTTGGAG GGCCTAAAATTTACGTTGAGCTTAATGTTAGCAGTAAAAGCGGATTACCAGTTGTTGGGCTTAA AAGTGAAAATTTTTCAATTTCAAATGAAAATTATTACATTGTCAATCCCAAGGTGGCATATAAT GTAAATGCTTCAAAAGACATTAATATAGCAGTTGTTTTTGATAAATCTTCTTATATGAAAAAAT ATGATACAGATCAAATTGTAGGGTTAAATGCCCTAATGGAGTTGTCAAAAAATAAAAACTTTAG TTTTATAAATGCAACAAGTGTGCCCATTATAGATAATATTGAAAGCTTAACAAATAGCATTAGA AATACAAGTTCTCTTGGTCCTTATAGTACAGATGCTGTAAAAACAGACGTTAGTTTGAAGTTGG CAGGTTCTGGGCTTATGTCAAAAAGCTCAAGAAGAGCAGTAGTTTATTTTAGTGGTGGTATTTT AAATCGTAAAGCTTTTGAAAAGTACTCTTTAGATACAATAGTAAGCTATTATAAAAATAATGAT ATAAGGTTTTACTTAATACTATTTGGTAATGATCCTATTAATAGTAAGCTTCAGTATTTAGTTAA TGAAACAGGCGGTGCTGTAATTCCTTTTTCATCTTATGAAGGTGTATCTAAAGTTTATGATTTAA TTTTAGAACAAAAAACGGGCACTTATTTGTTGGAATATTATTATCCAGGCCCTCAAGAACCTAA TAAATATTTTAATTTATCTGTTGAAGCAAATATAAATCAACAGACAGGAAGAGGGGAGTTTGCA TATTTTATTAATTAG t709.nt (SEQ ID NO:240) CAAGGAATAGTTACTAATAAAGATGCTCAAGAAGAGTTTAAATGGGCTCTTAATTCTTA TAATAATGGAATTTACGATGATGCTCTTTTATCTTTTAAAAAAATTTTAAGCTTTGATCCTAATA ATCTTGATTATCATTTTTGGACTGGCAATGTTTATTATAGACTGGGTTATGTTGAAGAAGCTTTA ATGGAATGGAGAAATTTAAAAGATCAAGGCTATAAGGTTCCCTATCTTAGACATTTGATTTCTA CTATTGAGCAAAGGAGAGGTATTTTTTCAAATTATGAACTTAATTTTAAAAAACTTGTAAAAGT TGCTTCTCTTGATAATTCTATTTATAAAAGGCCACATGGGTACCAGATTACATCTTTAAGGGCTG ATAAGTACGGCGGATATTACGCTGCTAACTTTGTAGGCAATGAAATATTGTATTTTGATGTTAA TAACAATGTTAATGCTTTAGTTAAAGATGGCTTTAGTTATTTAAAATCACCTTATGATGTTATTG AAGCTAATAATCTGCTTTATGTGACTCTTTATTCAAGTGATGAAATTGGTGTTTATGACAAAGTT CTTGGAGTTAAAAGGAAATCTATTGGGAATAAAGGCACAAAAGATGGCGAATTGCTTGCTCCT CAGTATATGGCTATTGATAAGAGAAACTATATTTATGTAAGTGAGTGGGGAAATAAAAGAGTA AGTAAATTTGGACTTGAAGGTGATTTTATTTTGCATTTTGGTTCTAGAACTTCAGGCTATAAGG GCCTTTTAGGTCCCACAGGCGTTACTTATTTGAATGAAAACATTTATGTTGCAGATTCTCTGAGA AATACCATTGAAGTTTTTGATACTAGTGGTAATCATTTATATTCAGTTTTTACTTCTATTGAGGG AATAGAGGGGCTTAGCAGTGATTTTGTAGGTAATAATGTTATAGTATCCTCAAAAGATGGTGTT TATAAATATAGCATTGCTAAAAAGACAATTACAAAAATTTTAAAAGCAGATAAAATGAATTCTA AAATTTCTTCATCTATTTTGGATGCCAATAATCAGATGATTGTCTCAGATTTTAATAATGCCAAG GTTTCAGTTTACAAGAGTGATGCAAGCCTTTATGATAGTTTAAATGTTGATGTTAGAAGAATAA TTAGGCTTGGAGGGCCTAAAATTTACGTTGAGCTTAATGTTAGCAGTAAAAGCGGATTACCAGT TGTTGGGCTTAAAAGTGAAAATTTTTCAATTTCAAATGAAAATTATTACATTGTCAATCCCAAG GTGGCATATAATGTAAATGCTTCAAAAGACATTAATATAGCAGTTGTTTTTGATAAATCTTCTT ATATGAAAAAATATGATACAGATCAAATTGTAGGGTTAAATGCCCTAATGGAGTTGTCAAAAA ATAAAAACTTTAGTTTTATAAATGCAACAAGTGTGCCCATTATAGATAATATTGAAAGCTTAAC AAATAGCATTAGAAATACAAGTTCTCTTGGTCCTTATAGTACAGATGCTGTAAAAACAGACGTT AGTTTGAAGTTGGCAGGTTCTGGGCTTATGTCAAAAAGCTCAAGAAGAGCAGTAGTTTATTTTA GTGGTGGTATTTTAAATCGTAAAGCTTTTGAAAAGTACTCTTTAGATACAATAGTAAGCTATTA TAAAAATAATGATATAAGGTTTTACTTAATACTATTTGGTAATGATCCTATTAATAGTAAGCTTC AGTATTTAGTTAATGAAACAGGCGGTGCTGTAATTCCTTTTTCATCTTATGAAGGTGTATCTAA AGTTTATGATTTAATTTTAGAACAAAAAACGGGCACTTATTTGTTGGAATATTATTATCCAGGC CCTCAAGAACCTAATAAATATTTTAATTTATCTGTTGAAGCAAATATAAATCAACAGACAGGAA GAGGGGAGTTTGCATATTTTATTAATTAG f730.aa (SEQ ID NO:241) MIKSILDYLLTLHPVLLGLLGSTFTWFTTAFGAAAVFFFRKVDNKIMDAMLGFSAGIMIAASFFSLIQ PAIERAEELGYITWVPAVFGFLVGAFFIYIVVDVFVPDLDKLTFIDEDLTKHGKKDFLLFTAVTLHNFP EGLAVGVAFGALASNPDIQTLVGAMLLTLGIGIQNIPEGAAISLPLRRGNVALAKCFNYGQMSGLVE IVGGLMGAYAVYSFTRILPFALAFSAGAMIYVSIEQLIPEAKRKDIDNKVPSIFGVIGFTLMMFLDVSL G t730.aa (SEQ ID NO:242) AVFFFRKVDNKIMDAMLGFSAGIMIAASFFSLIQPAIERAEELGYITWVPAVFGFLVGAFFIYIVDVFV PDLDKLTFIDEDLTKHGKKDFLLFTAVTLHNFPEGLAVGVAFGALASNPDIQTLVGAMLLTLGIGIQ NIPEGAAISLPLRRGNVALAKCFNYGQMSGLVEIVGGLMGAYAVYSFTRILPFALAFSAGAMIYVSIE QLIPEAKRKDIDNKVPSIFGVIGFTLMMFLDVSLG f730.nt (SEQ ID NO:243) ATGATAAAATCAATTTTAGATTATTTATTAACTTTGCATCCTGTATTATTGGGACTTTTAGGTTC TACTTTCACTTGGTTTACTACAGCTTTTGGAGCAGCAGCAGTTTTTTTCTTTAGAAAGGTAGATA ATAAAATAATGGACGCTATGCTTGGTTTTTCAGCTGGCATTATGATAGCGGCCAGTTTTTTTTCG CTTATTCAGCCTGCTATAGAAAGAGCTGAAGAGCTTGGATACATTACTTGGGTGCCGGCTGTTT TTGGATTTCTTGTTGGGGCATTTTTTATATATATTGTAGATGTATTTGTTCCAGATCTGGATAAA CTTACTTTTATTGATGAAGACTTAACTAAACATGGTAAAAAAGATTTTTTACTCTTTACTGCTGT TACTTTACATAATTTTCCAGAAGGATTGGCTGTTGGAGTTGCTTTTGGAGCCTTGGCGTCTAATC CAGATATTCAAACTTTAGTTGGGGCTATGCTTCTTACGCTTGGTATTGGTATTCAAAATATTCCC GAAGGAGCAGCTATTTCTCTGCCTTTAAGAAGAGGTAATGTTGCTTTGGCAAAATGCTTTAACT ATGGCCAAATGTCAGGATTGGTAGAAATTGTGGGGGGGCTTATGGGTGCTTATGCGGTTTATTC TTTTACTCGAATTTTACCTTTTGCTTTGGCTTTTTCTGCAGGAGCTATGATTTATGTGTCAATTG AACAATTAATACCTGAAGCTAAGAGAAAAGACATTGACAATAAAGTGCCAAGTATATTTGGTG TTATTGGTTTTACATTAATGATGTTTCTCGATGTTTCACTAGGTTAA t730.nt (SEQ ID NO:244) GCAGTTTTTTTCTTTAGAAAGGTAGATAATAAAATAATGGACGCTATGCTTGGTTTTTCAGCTG GCATTATGATAGCGGCCAGTTTTTTTTCGCTTATTCAGCCTGCTATAGAAAGAGCTGAAGAGCT TGGATACATTACTTGGGTGCCGGCTGTTTTTGGATTTCTTGTTGGGGCATTTTTTATATATATTG TAGATGTATTTGTTCCAGATCTGGATAAACTTACTTTTATTGATGAAGACTTAACTAAACATGGT AAAAAAGATTTTTTACTCTTTACTGCTGTTACTTTACATAATTTTCCAGAAGGATTGGCTGTTGG AGTTGCTTTTGGAGCCTTGGCGTCTAATCCAGATATTCAAACTTTAGTTGGGGCTATGCTTCTTA CGCTTGGTATTGGTATTCAAAATATTCCCGAAGGAGCAGCTATTTCTCTGCCTTTAAGAAGAGG TAATGTTGCTTTGGCAAAATGCTTTAACTATGGCCAAATGTCAGGATTGGTAGAAATTGTGGGG GGGCTTATGGGTGCTTATGCGGTTTATTCTTTTACTCGAATTTTACCTTTTGCTTTGGCTTTTTCT GCAGGAGCTATGATTTATGTGTCAATTGAACAATTAATACCTGAAGCTAAGAGAAAAGACATTG ACAATAAAGTGCCAAGTATATTTGGTGTTATTGGTTTTACATTAATGATGTTTCTCGATGTTTCA CTAGGTTAA f197.aa (SEQ ID NO:245) MLLKLKYRFVGFLLLFLIFILLLFSTIFNFVLCGYLEDYYKQLTRAQVRRAAFSLQSFLDTLHVIINGA ASNLALETISEFAMSENRGKDFSESELIDLRKNPKFVIDSVKVSKKYRQYLYNFMANLKNDTLFEEF AFFDFEGRVIVSTRHENNMDFGHSEANTNYFKKAVEDYRQNQLKFIGWYSNLSEGISAEVAIRSKQS EKKAFAIIVPVYSPEDKLVCGYLAGYLLNDIVADSFDRFRFGFYKRGNFIYVDPNNIAVNPFEEYNET SRVSSKFLNVLKDVFSKPPFPSNIASEVSVYTIDRILLSEMGEDCYYAMLPISSKLGEKSGVLIARLPY KDIYGVISSLRFQYILYSVLGIIALSIVLSIRIDRIISFRLNAIRVLVQDMVKGNLDKDYALDDDENTLD ELGMLSLQVVKMKKAISVAISSVLRNISYVNKASLEVASSSQNLSSSALQQASALEEMSANVEQIAS GVNMSANNSYETEQIALKTNENSQIGGRAVEESVIAMQDIVEKVSVIEEIARKTNLLALNAAIEAAR AGDEGKGFAVVASEIRKLADLSKISALEIGELVEDNSKVATEAGVIFKEMLPEIEETANLVKKISEGSS KQSDQIAQFKMALDQVGEVVQSSASSSEQLSSMSDKMLEKSKELRKSVLFFKIKDSKIENPENDDYD FRLIDCPENSFKDENQNLKSNGISTSNASGHNNYSLDIESESSVRTINKRVDPKKAIDIADKDLNFDDD FSEF t197.aa (SEQ ID NO:246) VLCGYLEDYYKQLTRAQVRRAAFSLQSFLDTLHVIINGAASNLALETISEFAMSENRGKDFSESELID LRKNPKFVIDSVKVSKKYRQYLYNFMANLKNDTLFEEFAFFDFEGRVIVSTRHENNMDFGHSEANT NYFKKAVEDYRQNQLKFIGWYSNLSEGISAEVAIRSKQSEKKAFAIIYPVYSPEDKLVCGYLAGYLL NDIVADSFDRFRFGFYKRGNFIYVDPNNIAVNPFEEYNETSRVSSKFLNVLKDVFSKPPFPSNIASEVS VYTIDRILLSEMGEDCYYAMLPISSKLGEKSGVLIARLPYKDIYGVISSLRFQYILYSVLGIIALSIVLSI RIDRIISFRLNAIRVLVQDMVKGNLDKDYALDDDENTLDELGMLSLQVVKMKKAISVAISSVLRNIS YVNKASLEVASSSQNLSSSALQQASALEEMSANVEQIASGVNMSANNSYETEQIALKTNENSQIGGR AVEESVIAMQDIVEKVSVIEEIARKTNLLALNAAIEAARAGDEGKGFAVVASEIRKLADLSKISALEIG ELVEDNSKVATEAGVIFKEMLPEIEETANLVKKISEGSSKQSDQIAQFKMALDQVGEVVQSSASSSE QLSSMSDKMLEKSKELRKSVLFFKIKDSKIENPENDDYDFRLIDCPENSFKDENQNLKSNGISTSNAS GHNNYSLDIESESSVRTINKRVDPKKAIDIADKDLNFDDDFSEF f197.nt (SEQ ID NO:247) ATGTTATTGAAGCTTAAATACAGGTTTGTTGGATTTTTATTATTGTTTTTAATTTTTATA CTGCTACTTTTTTCCACGATTTTTAATTTTGTTTTATGCGGTTATTTAGAAGATTATTATAAGCA GCTTACAAGGGCGCAAGTAAGAAGAGCAGCTTTTTCTTTGCAATCTTTTTTAGACACCCTGCAT GTCATAATCAATGGTGCAGCTTCTAATTTGGCACTTGAAACCATATCAGAATTTGCAATGTCTG AGAATAGAGGAAAAGATTTCTCTGAGTCGGAATTGATAGATTTAAGAAAAAATCCAAAATTTG TTATTGACTCTGTAAAGGTGAGCAAAAAATATCGACAATACTTATACAATTTTATGGCCAATCT TAAAAATGATACCCTTTTTGAAGAATTCGCTTTTTTTGATTTTGAAGGGAGAGTAATTGTTAGC ACAAGACATGAGAATAATATGGATTTTGGTCATTCTGAGGCTAATACCAATTATTTTAAAAAAG CTGTTGAGGATTATAGGCAAAACCAATTAAAATTTATAGGTTGGTATTCAAATCTTTCTGAAGG AATATCCGCAGAAGTTGCTATTAGGTCTAAACAAAGCGAAAAAAAGGCTTTTGCAATAATTGTA CCTGTATATTCCCCAGAAGATAAACTTGTTTGTGGGTATTTGGCCGGATATTTGCTTAATGATAT TGTGGCAGATAGTTTTGATAGATTTAGATTCGGTTTTTATAAAAGAGGCAATTTTATTTATGTG GATCCCAACAATATAGCAGTTAATCCTTTTGAAGAATATAATGAAACCAGCAGGGTTAGTTCTA AATTTTTGAATGTTCTTAAAGATGTTTTCTCTAAGCCCCCTTTTCCATCAAACATTGCCAGTGAA GTGTCGGTTTACACTATTGATAGAATACTTTTGTCCGAAATGGGAGAAGATTGTTATTATGCAA TGTTGCCCATAAGTAGTAAATTGGGAGAAAAGAGTGGAGTACTTATTGCTAGGCTTCCTTATAA GGATATTTTACGGAGTAATATCTAGTCTAAGATTTCAGTATATTTTATATTCAGTCTTAGGCATTA TAGCATTAAGTATTGTTCTTTCAATTAGAATAGACAGGATTATTAGTTTTCGTTTAAACGCAATT AGAGTTCTAGTTCAAGATATGGTTAAGGGCAATTTAGATAAAGATTATGCTCTTGATGATGATG AAAATACTCTTGATGAACTTGGCATGTTAAGTCTTCAGGTTGTTAAAATGAAAAAAGCTATTTC TGTAGCAATTTCTAGTGTTTTGAGAAATATTAGCTATGTAAATAAGGCAAGTTTAGAAGTTGCC AGTTCAAGTCAAAATTTAAGCTCTAGTGCATTGCAACAGGCATCTGCTCTTGAAGAAATGTCAG CTAATGTTGAGCAAATAGCCTCAGGTGTCAACATGAGCGCCAATAATTCTTATGAAACAGAACA AATAGCTTTAAAGACGAATGAAAATTCTCAGATAGGTGGTAGGGCCGTTGAAGAATCTGTTATT GCTATGCAAGACATTGTGGAGAAAGTTAGTGTTATTGAAGAGATAGCTAGAAAAACCAATTTA CTTGCTTTGAATGCGGCTATTGAAGCTGCAAGAGCAGGAGATGAGGGAAAGGGATTTGCTGTT GTGGCCAGTGAGATTAGAAAGTTGGCTGATTTGAGTAAAATTTCTGCTCTTGAGATTGGAGAGT TAGTTGAAGATAACTCTAAGGTAGCAACTGAAGCGGGAGTGATCTTTAAAGAAATGCTACCCG AAATTGAAGAAACGGCTAATCTTGTTAAGAAGATTTCAGAAGGTAGCTCTAAGCAAAGCGATC AGATTGCTCAATTTAAAATGGCTTTAGATCAGGTTGGAGAAGTTGTTCAATCTTCAGCTTCAAG CAGTGAGCAGCTTTCTAGTATGTCCGATAAAATGTTAGAAAAGTCTAAGGAACTTAGAAAATCT GTATTATTTTTCAAAATTAAAGATTCTAAAATTGAAAATCCAGAAAATGATGATTATGATTTCA GGTTAATAGATTGTCCTGAAAATTCTTTTAAAGATGAAAATCAAAATTTGAAAAGCAATGGAAT TTCTACTTCAAATGCCAGTGGGCATAATAATTATTCTTTAGATATTGAGAGCGAATCTTCTGTAA GAACTATTAATAAGCGAGTTGATCCTAAAAAAGCTATCGATATTGCTGATAAGGATTTAAATTT TGATGATGATTTTTCAGAGTTTTAG t197.nt (SEQ ID NO:248) GTTTTATGCGGTTATTTAGAAGATTATTATAAGCAGCTTACAAGGGCGCAAGTAAGAA GAGCAGCTTTTTCTTTGCAATCTTTTTTAGACACCCTGCATGTCATAATCAATGGTGCAGCTTCT AATTTGGCACTTGAAACCATATCAGAATTTGCAATGTCTGAGAATAGAGGAAAAGATTTCTCTG AGTCGGAATTGATAGATTTAAGAAAAAATCCAAAATTTGTTATTGACTCTGTAAAGGTGAGCAA AAAATATCGACAATACTTATACAATTTTATGGCCAATCTTAAAAATGATACCCTTTTTGAAGAA TTCGCTTTTTTTGATTTTGAAGGGAGAGTAATTGTTAGCACAAGACATGAGAATAATATGGATT TTGGTCATTCTGAGGCTAATACCAATTATTTTAAAAAAGCTGTTGAGGATTATAGGCAAAACCA ATTAAAATTTATAGGTTGGTATTCAAATCTTTCTGAAGGAATATCCGCAGAAGTTGCTATTAGG TCTAAACAAAGCGAAAAAAAGGCTTTTGCAATAATTGTACCTGTATATTCCCCAGAAGATAAAC TTGTTTGTGGGTATTTGGCCGGATATTTGCTTAATGATATTGTGGCAGATAGTTTTGATAGATTT AGATTCGGTTTTTATAAAAGAGGCAATTTTATTTATGTGGATCCCAACAATATAGCAGTTAATC CTTTTGAAGAATATAATGAAACCAGCAGGGTTAGTTCTAAATTTTTGAATGTTCTTAAAGATGT TTTCTCTAAGCCCCCTTTTCCATCAAACATTGCCAGTGAAGTGTCGGTTTACACTATTGATAGAA TACTTTTGTCCGAAATGGGAGAAGATTGTTATTATGCAATGTTGCCCATAAGTAGTAAATTGGG AGAAAAGAGTGGAGTACTTATTGCTAGGCTTCCTTATAAGGATATTTACGGAGTAATATCTAGT CTAAGATTTCAGTATATTTTATATTCAGTCTTAGGCATTATAGCATTAAGTATTGTTCTTTCAAT TAGAATAGACAGGATTATTAGTTTTCGTTTAAACGCAATTAGAGTTCTAGTTCAAGATATGGTT AAGGGCAATTTAGATAAAGATTATGCTCTTGATGATGATGAAAATACTCTTGATGAACTTGGCA TGTTAAGTCTTCAGGTTGTTAAAATGAAAAAAGCTATTTCTGTAGCAATTTCTAGTGTTTTGAG AAATATTAGCTATGTAAATAAGGCAAGTTTAGAAGTTGCCAGTTCAAGTCAAAATTTAAGCTCT AGTGCATTGCAACAGGCATCTGCTCTTGAAGAAATGTCAGCTAATGTTGAGCAAATAGCCTCAG GTGTCAACATGAGCGCCAATAATTCTTATGAAACAGAACAAATAGCTTTTAAAGACGAATGAAA ATTCTCAGATAGGTGGTAGGGCCGTTGAAGAATCTGTTATTGCTATGCAAGACATTGTGGAGAA AGTTAGTGTTATTGAAGAGATAGCTAGAAAAACCAATTTACTTGCTTTGAATGCGGCTATTGAA GCTGCAAGAGCAGGAGATGAGGGAAAGGGATTTGCTGTTGTGGCCAGTGAGATTAGAAAGTTG GCTGATTTGAGTAAAATTTCTGCTCTTGAGATTGGAGAGTTAGTTGAAGATAACTCTAAGGTAG CAACTGAAGCGGGAGTGATCTTTAAAGAAATGCTACCCGAAATTGAAGAAACGGCTAATCTTG TTAAGAAGATTTCAGAAGGTAGCTCTAAGCAAAGCGATCAGATTGCTCAATTTAAAATGGCTTT AGATCAGGTTGGAGAAGTTGTTCAATCTTCAGCTTCAAGCAGTGAGCAGCTTTCTAGTATGTCC GATAAAATGTTAGAAAAGTCTAAGGAACTTAGAAAATCTGTATTATTTTTCAAAATTAAAGATT CTAAAATTGAAAATCCAGAAAATGATGATTATGATTTCAGGTTAATAGATTGTCCTGAAAATTC TTTTAAAGATGAAAATCAAAATTTGAAAAGCAATGGAATTTCTACTTCAAATGCCAGTGGGCAT AATAATTATTCTTTAGATATTGAGAGCGAATCTTCTGTAAGAACTATTAATAAGCGAGTTGATC CTAAAAAAGCTATCGATATTGCTGATAAGGATTTAAATTTTGATGATGATTTTTCAGAGTTTTA G f200.aa (SEQ ID NO:249) MTISKNVFSKFILKFLNSSAFVSVFALFVGFLIVGLVVMGLGHSPFRMYFIILEIIFSSPKHLGYVLSYS APLIFTGLSIGISLKAGLFNIGVEGQFILGSIVALIASVLLDLPPILHVITIFIITFLASGSLGILIGYLKAKF NISEVISGIMFNWILFHLNNIILDFSFIKRDNSDFSKPIKESAYIDFLASWKLSPEGLAYRSSHPFVNELL KAPLHFGIILGIIFAILIWFLLNKTIIGFKINATGSNIEASRCMGINVKAVLIFSMFLSAAVAGLAGAIQL MGVNKAIFKLSYMQGIGFNGIAASLMGNNSPIGIIFSSILFSILLYGSSRVQSLMGLPSSIVSLMMGIIV LVISASYFLNKIVLKGVKRVKYNNILD t200.aa (SEQ ID NO:250) LVVMGLGHSPFRMYFIILEIIFSSPKHLGYVLSYSAPLIFTGLSIGISLKAGLFNIGVEGQFILGSIVALIA SVLLDLPPILHVITIFIITFLASGSLGILIGYLKAKFNISEVISGIMFNWILFHLNNIILDFSFIKRDNSDFSK PIKESAYIDFLASWKLSPEGLAYRSSHPFVNELLKAPLHFGIILGIIFAILIWFLLNKTIIGFKINATGSNI EASRCMGINVKAVLIFSMFLSAAVAGLAGAIQLMGVNKAIFKLSYMQGIGFNGIAASLMGNNSPIGII FSSILFSILLYGSSRVQSLMGLPSSIVSLMMGIIVLVISASYFLNKIVLKGVKRVKYNNILD f200.nt (SEQ ID NO:251) ATGACAATTAGTAAAAACGTATTTAGTAAATTTATTTTGAAATTTTTAAATTCTTCAGC ATTTGTTAGTGTATTTGCTCTATTTGTTGGATTTTTAATTGTTGGGCTAGTGGTGATGGGGCTTG GTCATTCTCCTTTTAGAATGTATTTTATAATATTAGAAATTATTTTTTCTTCTCCCAAACATTTAG GTTATGTTTTAAGTTATTCAGCTCCTTTGATTTTTACAGGTCTTTCTATTGGTATTTCTTTAAAAG CGGGTCTTTTTAATATTGGGGTTGAAGGCCAGTTTATACTAGGATCTATTGTTGCTTTAATAGCA TCAGTTTTACTTGATTTGCCTCCAATTTTACATGTAATTACTATTTTTATTATTACTTTTTTAGCT TCAGGCAGTTTAGGAATTTTAATCGGATATTTAAAAGCCAAATTCAATATTAGCGAAGTGATTT CAGGAATAATGTTTAATTGGATATTATTTCATTTAAATAATATAATTTTAGATTTTAGTTTTATT AAAAGAGATAATAGTGATTTTTCAAAACCCATTAAAGAAAGCGCATATATTGATTTTTTAGCTT CTTGGAAGCTCTCACCAGAAGGTCTTGCTTATAGATCTTCTCATCCTTTTGTTAATGAGCTTTTA AAAGCACCTCTTCATTTTGGAATAATTTTAGGTATAATTTTTGCTATTTTAATATGGTTTTACT TAATAAAACTATTATTGGATTTAAAATAAATGCCACAGGAAGTAATATTGAAGCTTCAAGATGT ATGGGTATTAATGTAAAAGCTGTGCTAATTTTTTCAATGTTTCTCTCAGCAGCTGTTGCAGGTCT TGCTGGTGCTATTCAACTTATGGGTGTTAATAAAGCTATATTTAAGCTTTCTTATATGCAAGGA ATTGGTTTTAATGGGATAGCTGCTTCTCTTATGGGAAACAATTCGCCAATTGGCATAATATTTTC TAGCATTCTTTTTTCTATATTGCTTTATGGAAGCAGTAGAGTTCAAAGTTTAATGGGCCTTCCAT CTTCAATTGTATCTTTGATGATGGGAATAATTGTTCTTGTAATTTCTGCTAGCTATTTTTTAAAT AAAATTGTTTTAAAAGGTGTTAAGCGTGTCAAATATAATAATATTCTTGATTAG t200.nt (SEQ ID NO:252) GGGCTAGTGGTGATGGGGCTTGGTCATTCTCCTTTTAGAATGTATTTTATAATATTAGA AATTATTTTTTCTTCTCCCAAACATTTAGGTTATGTTAAGTTATTCAGCTCCTTTGATTTTTAC AGGTCTTTCTATTGGTATTTCTTTAAAAGCGGGTCTTTTTAATATTGGGGTTGAAGGCCAGTTTA TACTAGGATCTATTGTTGCTTTAATAGCATCAGTTTTACTTGATTTGCCTCCAATTTTACATGTA ATTACTATTTTTATTATTACTTTTTTAGCTTCAGGCAGTTTAGGAATTTTAATCGGATATTTAAA AGCCAAATTCAATATTAGCGAAGTGATTTCAGGAATAATGTTTAATTGGATATTATTTCATTTA AATAATATAATTTTAGATTTTAGTTTTATTAAAAGAGATAATAGTGATTTTTCAAAACCCATTAA AGAAAGCGCATATATTGATTTTTTAGCTTCTTGGAAGCTCTCACCAGAAGGTCTTGCCTATAGA TCTTCTCATCCTTTTGTTAATGAGCTTTTAAAAGCACCTCTTCATTTTGGAATAATTTTAGGTAT AATTTTTGCTATTTTAATATGGTTTTTACTTAATAAAACTATTATTGGATTTAAAATAAATGCCA CAGGAAGTAATATTGAAGCTTCAAGATGTATGGGTATTAATGTAAAAGCTGTGCTAATTTTTTC AATGTTTCTCTCAGCAGCTGTTGCAGGTCTTGCTGGTGCTATTCAACTTATGGGTGTTAATAAAG CTATATTTAAGCTTTCTTATATGCAAGGAATTGGTTTTAATGGGATAGCTGCTTCTCTTATGGGA AACAATTCGCCAATTGGCATAATATTTTCTAGCATTCTTTTTTCTATATTGCTTTATGGAAGCAG TAGAGTTCAAAGTTTAATGGGCCTTCCATCTTCAATTGTATCTTTGATGATGGGAATAATTGTTC TTGTAATTTCTGCTAGCTATTTTTTAAATAAAATTGTTTTAAAAGGTGTTAAGCGTGTCAAATAT AATAATATTCTTGATTAG f208.aa (SEQ ID NO:253) MVKKFSIFLKAIIIFSIFELLIEELSIILFLPYKIRFALIFLGFLFDTIFIFIFLYKITKAYLSQRLEIYVRNNL FFDIIHCLIPLAFYSSYQLKNIIVAHETILNPIMLSLFKLRFLRLLRFNDLIIEIYYNSKEKNLILLAFARTF SMSLLIPFTFFIIISSSKIVNSIPEKQEFNIIKNISIINEKAYIKEKYPFILIIKEKDDIIYSKSDEIFVYYSPSE YRVIEMEKTKFYIDKYLQRKSDSILGIFLFTLFASFTIFLMNFYKFFKASFLNPIILMTKILQDPLEYRKI QIPFTLSEEKVYELAKSFNNLLLKEKLNSKRKSKIPLEIEKVKKIINKNQEIK t208.aa (SEQ ID NO:254) IIIFSIFELLIEELSIILFLPYKIRFALIFLGFLFDTIFIFIFLYKITKAYLSQRLEIYVRNNLFFDIIHCLIPLAF YSSYQLKNIIVAHETILNPIMLSLFKLRFLRLLRFNDLIIEIYYNSKEKNLILIAFARTFSMSLLIPFTFFIII SSSKIVNSIPEKQEFNIIKNISIINEKAYIKEKYPFILIIKEKDDIIYSKSDEIFVYYSPSEYRVIEMEKTKF YIDKYLQRKSDSILGIFLFTLFASFTIFLMNFYKFFKASFLNPIILMTKILQDPLEYRKIQIPFTLSEEKV YELAKSFNNLLLKEKLNSKRKSKIPLEIEKVKKHIINKNQEIK f208.nt (SEQ ID NO:255) ATGGTAAAAAAATTTTCAATTTTCTTAAAAGCAATAATAATTTTTTCAATATTTGAACTTTTAAT CGAAGAACTCTCAATAATTCTTTTTTTACCATACAAAATACGATTTGCACTAATATTTCTTGGGT TTCTATTTGACACAATTTTTATTTTCATTTTTTTATACAAAATAACCAAGGCCTACCTTTCCCAA AGATTAGAAATCTACGTCAGAAACAATCTATTCTTCGATATAATCCACTGCCTTATTCCTTTAGC GTTTTATAGCTCATATCAGCTTAAAAACATAATTGTCGCCCATGAAACAATATTAAATCCAATA ATGCTATCACTTTTCAAGTTAAGATTTTTAAGACTTCTTAGGTTTAATGACCTAATAATAGAAAT ATATTACAATTCAAAAGAAAAGAACCTAATACTAATAGCATTTGCTAGGACATTTTCAATGAGC TTATTAATACCATTTACATTTTTTATAATAATATCAAGCTCAAAAATTGTAAATTCAATACCAGA AAAACAAGAATTTAATATCATTAAAAATATATCAATAATAAATGAAAAAGCTTACATTAAAGA AAAATATCCCTTCATCTTAATAATCAAGGAAAAAGATGACATAATATACTCAAAATCAGACGAA ATATTTGTTTACTACAGTCCCAGTGAATATAGAGTAATAGAAATGGAGAAAACAAAATTTTATA TAGATAAATATTTGCAAAGAAAAAGCGATTCTATTCTTGGAATTTTTCTATTTACATTGTTTGCA TCATTTACTATTTTTTTAATGAATTTTTATAAATTTTTTAAAGCAAGGTTTTTAAATCCTATTATT TTAATGACAAAAATTTTACAAGACCCATTAGAATATCGAAAAATTCAAATTCCTTTTACTTTAA GCGAAGAAAAAGTATATGAACTTGCAAAATCATTTAACAATCTCTTGCTAAAAGAAAAACTAA ACTCAAAGCGAAAAAGCAAAATACCTTTAGAAATTGAAAAAGTAAAAAAAATAATTAATAAAA ACCAGGAAATAAAATGA t208.nt (SEQ ID NO:256) ATAATAATTTTTTCAATATTTGAACTTTTAATCGAAGAACTCTCAATAATTCTTTTTTTACCATA CAAAATACGATTTGCACTAATATTTCTTGGGTTTCTATTTGACACAATTTTTATTTTCATTTTTTT ATACAAAATAACCAAGGCCTACCTTTCCCAAAGATTAGAAATCTACGTCAGAAACAATCTATTC TTCGATATAATCCACTGCCTTATTCCTTTAGCGTTTTATAGCTCATATCAGCTTAAAAACATAAT TGTCGCCCATGAAACAATATTAAATCCAATAATGCTATCACTTTTCAAGTTAAGATTTTTAAGA CTTCTTAGGTTTAATGACCTAATAATAGAAATATATTACAATTCAAAAGAAAAGAACCTAATAC TAATAGCATTTGCTAGGACATTTTCAATGAGCTTATTAATACCATTTACATTTTTTATAATAATA TCAAGCTCAAAAATTGTAAATTCAATACCAGAAAAACAAGAATTTAATATCATTAAAAATATAT CAATAATAAATGAAAAAGCTTACATTAAAGAAAAATATCCCTTCATCTTAATAATCAAGGAAAA AGATGACATAATATACTCAAAATCAGACGAAATATTTGTTTACTACAGTCCCAGTGAATATAGA GTAATAGAAATGGAGAAAACAAAATTTTATATAGATAAATATTTGCAAAGAAAAAGCGATTCT ATTCTTGGAATTTTTCTATTTACATTGTTTGCATCATTTACTATTTTTTTAATGAATTTTTATAAA TTTTTTAAAGCAAGCTTTTTAAATCCTATTATTTTAATGACAAAAATTTTACAAGACCCATTAGA ATATCGAAAAATTCAAATTCCTTTTACTTTAAGCGAAGAAAAAGTATATGAACTTGCAAAATCA TTTAACAATCTCTTGCTAAAAGAAAAACTAAACTCAAAGCGAAAAAGCAAAATACCTTTAGAA ATTGAAAAAGTAAAAAAAATAATTAATAAAAACCAGGAAATAAAATGA f210.aa (SEQ ID NO:257) MKIQIIIMLLALLDFPLNARLLDISIEKRADEEIKKYSSYNLILEKEYYTNFPTSEIEKNIYKLTEHFVKS IMLNKTNYSLLNSNYKEANKYLIQSELIDKKFLKYKIFKIKNINGIFKSHSLIYTKKGFYKLELYIENN AEPLKIFNLNITYFLKNLDKISNEMIFFPREKREVNMIQKTTIAADSSSKPRGINYDTGIPFNVLIVDDS VFTVKQLTQIFTSEGFNIIDTAADGEEAVIKYKNHYPNIDIVTLDITMPKMDGITCLSNIMEFDKNAR VIMISALGKEQLVKDCLIKGAKTFIVKPLDRAKVLQRVMSVFVK t210.aa (SEQ ID NO:258) RLLDISIEKRADEEIKKYSSYNLILEKEYYTNFPTSEIEKNIYKLTEHFVKSIMLNKTNYSLLN SNYKEANKYLIQSELIDKKFLKYKIFKIKNINGIFKSHSLIYTKKGFYKLELYIENNAEPLKIFNLNITY FLKNLDKISNEMIFFPREKREVNMIQKTTIAADSSSKPRGINYDTGIPFNVLIVDDSVFTVKQLTQIFTS EGFNIIDTAADGEEAVIKYKNHYPNIDIVTLDITMPKiMDGITCLSNIMEFDKNARVIMISALGKEQLV KDCLIKGAKTFIVKPLDRAKVLQRVMSVFVK f210.nt (SEQ ID NO:259) ATGAAAATTCAAATAATTATAATGCTGCTTGCATTGTTAGATTTTCCACTTAATGCCAG ACTTTTGGACATTTCAATTGAAAAAAGAGCAGATGAAGAAATAAAAAAATATTCGTCTTATAAT TTAATTTTAGAAAAAGAATACTATACCAATTTTCCAACAAGCGAAATAGAAAAAAATATTTATA AACTAACAGAACATTTTGTAAAAAGCATAATGCTCAATAAAACTAACTACAGCTTAATTAAATTC AAACTACAAAGAAGCAAATAAATATCTAATTCAAAGCGAACTCATTGATAAAAAATTTTTAAAA TATAAAATATTTAAAATCAAAAATATAAATGGAATTTTTAAAAGCCATTCACTAATATATACAA AAAAAGGATTTTACAAATTAGAACTTTACATAGAAAATAATGCAGAACCTCTAAAAATATTTAA CCTTAACATTACTTATTTTTTAAAGAATTTAGATAAAATAAGTAATGAAATGATTTTTTTCCCAA GGGAATGA t210.nt (SEQ ID NO:260) AGACTTTTTGGACATTTCAATTGAAAAAAGAGCAGATGAAGAAATAAAAAAATATTCGTCTTATA ATTTAATTTTAGAAAAAGAATACTATACCAATTTTCCAACAAGCGAAATAGAAAAAAATATTTA TAAACTAACAGAACATTTTGTAAAAAGCATAATGCTCAATAAAACTAACTACAGCTTATTAAAT TCAAACTACAAAGAAGCAAATAAATATCTAATTCAAAGCGAACTCATTGATAAAAAATTTTTAA AATATAAAATATTTAAAATCAAAAATATAAATGGAATTTTTAAAAGCCATTCACTAATATATAC AAAAAAAGGATTTTACAAATTAGAACTTTACATAGAAAATAATGCAGAACCTCTAAAAATATTT AACCTTAACATTACTTATTTTTTAAAGAATTTAGATAAAATAAGTAATGAAATGATTTTTTTCC AAGGGAATGA f22.aa (SEQ ID NO:261) MLKTLTKIITISCLIVGCASLPYTPPKQNLNYLMELLPGANLYAHVNLIKNRSIYNSLSPKYKSVLGLI SNLYFSYKKENNDFALLIMGNFPKDIFWGIHKNRNTESIGNIFTNPKWKLKNSNIYIIPNKARTSIAIT QKDITAKDNNMLTTKYIGEIEKNEMFFWIQDPTLLLPNQIVSSKNLIPFSSGTLSINSLNQEEYIFKSLI KTNNPPILKILSKKLIPTVLTNMTNLTISSHIKTTIKDQNTVEIEFNIQKSSVESLIEKLASNIQT t22.aa (SEQ ID NO:262) PYTPPKQNLNYLMELLPGANLYAHVNLIKNRSIYNSLSPKYKSVLGLISNLYFSYKKENNDFALLIM GNFPKDIFWGIHKNRNTESIGNIFTNPKWKLKNSNIYIIPNKARTSIAITQKDITAKDNNMLTTKYIGEI EKNEMFFWIQDPTLLLPNQIVSSKNLIPFSSGTLSINSLNQEEYIFKSLIKTNNPPILKILSKKLIPTVLTN MTNLTISSHIKTTIKDQNTVEIEFNIQKSSVESLIEKLASNIQT f22.nt (SEQ ID NO:263) ATGTTAAAAACATTAACAAAAATAATTACCATTTCATGCCTCATAGTGGGATGCGCAAGCCTGC CTTACACTCCTCCAAAACAAAATCTAAATTACTTAATGGAACTTTTACCTGGCGCAAATTTATAC GCCCATGTAAATTTAATTAAAAACAGGTCTATTTATAACTCTTTAAGCCCTAAATATAAATCAG TTCTTGGGCTTATAAGCAATTTATACTTTAGCTATAAAAAAGAAAATAACGATTTTGCTCTACTA ATAATGGGTAATTTCCCAAAAGATATTTTCTGGGGAATTCATAAAAATAGAAATACAGAATCAA TAGGCAATATATTTACAAATCCAAAATGGAAACTTAAAAATTCAAATATATACATTATTCCAAA CAAAGCTAGAACTAGCATTGCAATAACCCAAAAAGATATAACCGCAAAAGACAATAATATGCT AACAACAAAATATATTGGGGAAATAGAAAAAAATGAAATGTTTTTTTGGATTCAAGATCCAAC ATTATTGCTCCCAAACCAAATAGTAAGCAGCAAAAATTTAATTCCCTTTAGCAGTGGAACTTTG TCTATAAACAGCTTAAATCAAGAAGAATATATTTTTAAATCCTTAATCAAAACAAATAATCCAC CAATACTAAAAATATTGTCAAAAAAGTTAATTCCAACCGTCTTGACAAACATGACAAACCTCAC AATATCAAGCCACATAAAGACCACAATAAAAGACCAAAATACGGTTGAAATAGAATTTAATAT TCAAAAATCTAGTGTTGAAAGCCTTATAGAAAAACTAGCTTCAAATATTCAAACCTAA t22.nt (SEQ ID NO:264) CCTTACACTCCTCCAAAACAAAATCTAAATTACTTAATGGAACTTTTACCTGGCGCAAATTTATA CGCCCATGTAAATTTAATTAAAAACAGGTCTATTTATAACTCTTTAAGCCCTAAATATAAATCA GTTCTTGGGCTTATAAGCAATTTATACTTTAGCTATAAAAAAGAAAATAACGATTTTGCTCTAC TAATAATGGGTAATTTCCCAAAAGATATTTTCTGGGGAATTCATAAAAATAGAAATACAGAATC AATAGGCAATATATTTACAAATCCAAAATGGAAACTTAAAAATTCAAATATATACATTATTCCA AACAAAGCTAGAACTAGCATTGCAATAACCCAAAAAGATATAACCGCAAAAGACAATAATATG CTAACAACAAAATATATTGGGGAAATAGAAAAAAATGAAATGTTTTTTTGGATTCAAGATCCAA CATTATTGCTCCCAAACCAAATAGTAAGCAGCAAAAATTTAATTCCCTTTAGCAGTGGAACTTT GTCTATAAACAGCTTAAATCAAGAAGAATATATTTTTAAATCCTTAATCAAAACAAATAATCCA CCAATACTAAAAATATTGTCAAAAAAGTTAATTCCAACCGTCTTGACAAACATGACAAACCTCA CAATATCAAGCCACATAAAGACCACAATAAAAGACCAAAATACGGTTGAAATAGAATTTAATA TTCAAAAATCTAGTGTTGAAAGCCTTATAGAAAAACTAGCTTCAAATATTCAAACCTAA f221.aa (SEQ ID NO:265) MGITVFYLFSIFASFVLGSSMDSVKENVLKSTIFYYDVEEVEFPYARKQTLQFIAKTHLKYAVFNFDK NKMFSYTFVFDKKLISQYAIFIEVKKKFGEATLVTPLNYLWDLGDSIIVLNKNILRITLKSYISNYNK t221.aa (SEQ ID NO:266) SMDSVKENVLKSTIFYYDVEEVEFPYARKQTLQFIAKTHLKYAVFNFDKNKMFSYTFVFDKKLISQ YAIFIEVKKKFGEATLVTPLNYLWDLGDSIIVLNKNILRITLKSYISNYNK f221.nt (SEQ ID NO:267) ATGGGTATTACAGTTTTTTATTTATTTTCTATTTTTGCATCTTTTGTTCTGGGTTCTAGCATGGAT TCTGTTAAAGAGAATGTTCTCAAGAGCACTTTTTTATTATGATGTTGAAGAAGTTGAATTTCC TTATGCTAGGAAGCAGACTTTACAATTTATTGCTAAAACCCATTTAAAATATGCTGTTTTTAATT TTGACAAAAATAAAATGTTTTCGTACACTTTTGTTTTTGATAAAAAATTAATATCTCAGTATGCA ATTTTTATTGAGGTAAAGAAAAAGTTTGGCGAGGCTACACTAGTAACGCCTTTGAATTATTTAT GGGATCTTGGTGATTCTATTATTGTTTTAAATAAAAATATTTTAAGAATTACTTTAAAATCTTAT ATTTCAAATTATAATAAATGA t221.nt (SEQ ID NO:268) AGCATGGATTCTGTTAAAGAGAATGTTCTCAAGAGCACTATTTTTTATTATGATGTTGAAGAAG TTGAATTTCCTTATGCTAGGAAGCAGACTTTACAATTTATTGCTAAAACCCATTTAAAATATGCT GTTTTTAATTTTGACAAAAATAAAATGTTTTCGTACACTTTTGTTTTTGATAAAAAATTAATATC TCAGTATGCAATTTTTATTGAGGTAAAGAAAAAGTTTGGCGAGGCTACACTAGTAACGCCTTTG AATTATTTATGGGATCTTGGTGATTCTATTATTGTTTTAAATAAAAATATTTTAAGAATTACTTT AAAATCTTATATTTCAAATTATAATAAATGA f253.aa (SEQ ID NO:269) MYMENIEVRGQPNFFGLIPFFVFIIIYLGTGIYLGVIGVEMAFYQLPASVAMFFASIVCFLVFKGKFSD KIHIFIKGAAQYDIILMCLIFMLSGAFSSLCKEIGCVETVANLGIKYINPNWIVSGIFFVTCFLSFSAGTS VGSIVAIAPIAFNIAVKSGINPNLIAASVMCGAMFGDNLSLISDTTIVSSRTQGSSILDVFISSSFYAFPS AILTFFSFFFLSENLSNATNFLHESSIDLVKTVPYLMIIFFSLAGMNVFIVLFLGILSICLISVLYGNLYFL DVMKNINKGFLNMADLIFLSILTGGVSFAVIHNGGFKWLLIKLKSLIRGKSSAEFSIGAFVSIVDVFLA NNTIAILICGKVAKKIAFENNISVQRSASILDMFSCIFQGIIPYGAQMIILVNFSNGLVSPISILPFLVYFG FLLFFVILSILGLDIKKVFLFFLKK t253.aa (SEQ ID NO:270) LVFKGKFSDKIHIFIKGAAQYDIILMCLIFMLSGAFSSLCKEIGCVETVANLGIKYINPNWIVSGIFFVT CFLSFSAGTSVGSIVAIAPIAFNIAVKSGINPNLIAASVMCGAMFGDNLSLISDTTIVSSRTQGSSILDVF ISSSFYAFPSAILTFFSFFFLSENLSNATNFLHESSIDLVKTVPYLMIIFFSLAGMNVFIVLFLGILSICLIS VLYGNLYFLDVMKNINKGFLNMADLIFLSILTGGVSFAVHKNGGFKWLLIKLKSLIRGKSSAEFSIGA FVSIVDVFLANNTIAILICGKVAKKIAFENNISVQRSASILDMFSCIFQGIIPYGAQMIILVNFSNGLVSPI SILPFLVYFGFLLFFVILSILGLDIKKVFLFFLKK f253.n (SEQ ID NO:271) ATGTATATGGAAAATATTGAAGTAAGAGGGCAGCCAAATTTTTTTGGGCTTATTCCTTTTTTTGT TTTTATTATTATCTATTTAGGCACGGGGATTTATTTGGGAGTTATTGGTGTAGAAATGGCCTTTT ATCAACTGCCGGCTAGTGTTGCAATGTTTTTTGCTTCCATTGTTTGTTTTTTGGTATTTAAAGGA AAATTTTCCGACAAAATTCACATATTTATTAAAGGAGCAGCTCAGTACGATATTATACTAATGT GTCTTATTTTTATGCTTTCGGGAGCTTTCTCTTCTCTTTGTAAAGAAATAGGCTGCGTTGAAACT GTAGCAAATTTGGGAATTAAATATATTAATCCTAATTGGATTGTTTCTGGTATATTTTTTGTAAC CTGCTTTCTTTCTTTTTCTGCCGGCACTTCTGTTGGATCTATCGTTGCAATTGCTCCTATTGCTTT TAATATTGCTGTTAAAAGCGGCATTAATCCGAATTTAATAGCAGCATCTGTAATGTGTGGAGCT ATGTTTGGAGATAATCTTTCTTTAATATCAGATACAACTATTGTTTCTAGTCGAACTCAAGGTAG TAGCATCTTAGATGTTTTTATTAGTAGCAGTTTTTATGCTTTTCCATCCGCCATACTAACTTTTTT TTCTTTTTTCTTTCTTTCTGAAAATTTGTCCAATGCCACAAACTTTTTACACGAAAGTTCAATAG ATTTAGTGAAAACTGTGCCTTATTTAATGATTATATTTTTCTCTTTAGCTGGAATGAATGTTTTT ATAGTTCTTTTTTTAGGTATTCTTTCTATATGTCTTATTAGCGTTTTGTATGGTAATTTATACTTT CTAGATGTAATGAAAAACATTAATAAAGGGTTTTTAAATATGGCGGATTTGATTTTTCTTTCAA TTTTAACAGGGGGAGTTTCTTTTGCCGTGATTCATAATGGAGGCTTTAAATGGCTACTTATTAA ATTAAAATCCTTGATTAGAGGAAAAAGTTCAGCGGAATTTTCTATTGGGGCTTTTGTTTCAATA GTTGATGTTTTTCTTGCTAATAACACAATTGCCATACTTATTTGCGGCAAAGTAGCAAAAAAGA TAGCTTTTGAAAATAACATCAGTGTTCAAAGAAGTGCTTCTATTTTAGATATGTTCTCTTGTATT TTTCAAGGCATTATTCCTTATGGTGCGCAAATGATTATTTTAGTGAATTTTTCAAATGGACTTGT GTCGCCAATTAGTATTTTGCCATTTTTAGTTTATTTTGGATTTTTATTGTTTTTTGTTATTTTATC TATTTTGGGCCTTGATATAAAAAAAGTTTTTTTATTTTTTTTAAAAAAATAA t253.nt (SEQ ID NO:272) TTGGTATTTAAAGGAAAATTTTCCGACAAAATTCACATATTTATTAAAGGAGCAGCTCAGTACG ATATTATACTAATGTGTCTTATTTTTATGCTTTCGGGAGCTTTCTCTTCTCTTTGTAAAGAAATA GGCTGCGTTGAAACTGTAGCAAATTTGGGAATTAAATATATTAATCCTAATTGGATTGTTTCTG GTATATTTTTTGTAACCTGCTTTCTTTCTTTTTCTGCCGGCACTTCTGTTGGATCTATCGTTGCAA TTGCTCCTATTGCTTTTAATATTGCTGTTAAAAGCGGCATTAATCCGAATTTAATAGCAGCATCT GTAATGTGTGGAGCTATGTTTGGAGATAATCTTTCTTTAATATCAGATACAACTATTGTTTCTAG TCGAACTCAAGGTAGTAGCATCTTAAGATGTTTTTATTAGTAGCAGTTTTTATGCTTTTCCATCCG CCATACTAACTTTTTTTTCTTTTTTCTTTCTTTCTGAAAATTTGTCCAATGCCACAAACTTTTTAC ACGAAAGTTCAATAGATTTAGTGAAAACTGTGCTTATTTAATGATTATATTTTTCTCTTTAGCT GGAATGAATGTTTTTATAGTTCTTTTTTTAGGTATTCTTTCTATATGTCTTATTAGCGTTTTGTAT GGTAATTTATACTTTCTAGATGTAATGAAAAACATTAATAAAGGGTTTTAAATATGGCGGATT TGATTTTTCTTTCAATTTTAACAGGGGGAGTTTCTTTTGCCGTGATTCATAATGGAGGCTTTAAA TGGCTACTTATTAAATTAAAATCCTTGATTAGAGGAAAAAGTTCAGCGGAATTTTCTATTGGGG CRTTTGTTTCAATAGTTGATGTTTTTCTTGCTAATAACACAATTGCCATACTTATTTGCGGCAAA GTAGCAAAAAAGATAGCTTTTGAAAATAACATCAGTGTTCAAAGAAGTGCTTCTATTTTAGATA TGTTCTCTTGTATTTTTCAAGGCATTATTCCTTATGGTGCGCAAATGATTATTTTAGTGAATTTT TCAAATGGACTTGTGTCGCCAATTAGTATTTTGCCATTTTTAGTTTATTTTGGATTTTTATTGTTT TTTGTTATTTTATCTATTTTGGGCCTTGATATAAAAAAAGTTTTTTTATTTTTTTTAAAAAAATA A f265.aa (SEQ ID NO:273) MRKCFVSLSLLLIFFACSSNVEIELNDDISGIVSIFVNVNREFEKIRKELLTTLVGEEIANMPLFPVDEIK KYFKNGEEKLGLKLLSIKTQGDSINLVVKFDNLIKILGDYMKKPDISVFKIEKKDGKNIIELNINLENA TKNINENKEYISDALAALLPSDEIPMSAKEYKDVLVYFLSDFTSKASELIDNSKLNLVVKTSRNVQEQ FGFKQINSNTLRFEMDMVKGLSLETPIKLRLV Y t265.aa (SEQ ID NO:274) SNVEIELNDDISGIVSIFVNVNREFEKIRKELLTTLVGEEIANMPLFPVDEIKKYFKNGEEKLGLKLLSI KTQGDSINLVVKFDNLIKILGDYMKKPDISVFKIEKKDGKNIIELNINLENATKNINENKEYISDALAA LLPSDEIPMSAKEYKDVLVYFLSDFTSKASELIDNSKLNLVVKTSRNVQEQFGFKQINSNTLRFEMD MVKGLSLETPIKLRLVY f265.nt (SEQ ID NO:275) ATGAGAAAGTGTTTTGTTAGCTTGAGTTTATTGTTGATTTTTTTTGCTTGTAGCTCTAATGTTGA AATTGAGTTAAATGATGATATTAGTGGTATTGTTTCAATATTTGTTAATGTTAATAGAGAATTT GAAAAAATTAGAAAAGAACTCTTAACAACTTTGGTGGGAGAAGAAATTGCAAATATGCCTCTTT TTCCTGTAGATGAAATAAAAAAATACTTTAAAAATGGAGAGGAAAAGCTTGGGCTTAAGCTTTT GAGTATTAAAACCCAAGGAGATTCTATTAATTTAGTTGTTAAGTTTGATAATTTAATTAAAATTT TAGGCGATTATATGAAAAAACCCGATATATCTGTGTTTAAGATAGAAAAAAAAGATGGTAAAA ATATTATTGAACTTAATATTAATTTGGAAAACGCTACTAAGAATATTAATGAAAATAAAGAATA TATTAGTGATGCACTTGCTGCTCTTTTGCCATCGGATGAGATCCCAATGTCTGCCAAAGAATAT AAAGATGTTTTGGTTTATTTTTTATCGGATTTTACTTCCAAAGCAAGTGAACTTATTGACAATTC CAAACTTAATCTTGTAGTTAAGACTTCTAGAAATGTTCAAGAACAATTTGGATTCAAACAAATT AACTCAAACACACTGCGGTTTGAGATGGATATGGTTAAAGGATTAAGTCTTGAAACACCAATAA AACTTAGATTAGTTTATTGA t265.nt (SEQ ID NO:276) TCTAATGTTGAAATTGAGTTAAATGATGATATTAGTGGTATTGTTTCAATATTTGTTAATGTTAA TAGAGAATTTGAAAAAATTAGAAAAGAACTCTTAACAACTTTGGTGGGAGAAGAAATTGCAAA TATGCCTCTTTTTCCTGTAGATGAAATAAAAAAATACTTTAAAAATGGAGAGGAAAAGCTTGGG CTTAAGCTTTTGAGTATTAAAACCCAAGGAGATTCTATTAATTTAGTTGTTAAGTTTGATAATTT AATTAAAATTTTAGGCGATTATATGAAAAAACCCGATATATCTGTGTTTAAGATAGAAAAAAAA GATGGTAAAAATATTATTGAACTTAATATTAATTTGGAAAACGCTACTAAGAATATTAATGAAA ATAAAGAATATATTAGTGATGCACTTGCTGCTCTTTTGCCATCGGATGAGATCCCAATGTCTGC CAAAGAATATAAAGATGTTTTGGTTTATTTTTTATCGGATTTTACTTCCAAAGCAAGTGAACTTA TTGACAATTCCAAACTTAATCTTGTAGTTAAGACTTCTAGAAATGTTCAAGAACAATTTGGATT CAAACAAATTAACTCAAACACACTGCGGTTTGAGATGGATATGGTTAAAGGATTAAGTCTTGAA ACACCAATAAAACTTAGATTAGTTTATTGA f269.aa (SEQ ID NO:277) MNIRKLLFCIFFMNISFLLFAGDYKGLDFKIKFFNQSIYRVNSNVFIEVSLSNASESVLTLEIG DINSFGFDFDVTDTTNIKVKRPLEYVKKRSKNVAIPVRNMSLRPNEKFSVVINLNQFVKFSKDGVYF VKGIFFPDISDPSKKKESNIITLFLNDGFDENPGSIDLVNLSENNDIQDILKKKKLSPDEIVKYLLKALQ LGKKEKFFLYLDIEGLLLNDKGKAYLYKQKLSPIPNKNVVEEYKEYLWNSNNSDISKAPNKFSIIETT YSDTSGKVIADLYFDDGQFYISKRYTFFFKKYDYYWIIYDYIVQNTGIKEK t269.aa (SEQ ID NO:278) GDYKGLDFKIKFFNQSIYRVNSNVFIEVSLSNASESVLTLEIGDINSFGFDFDVTDTTNIKVKRPIEYV KKRSKNVAIPVRNMSLRPNEKFSVVTINLNQFVKFSKDGVYFVKGIFFPDISDPSKKKESNIITLFLNDG FDENPGSIDLVNLSENNDIQDILKKKKLSPDEIVKYLLKALQLGKKEKFFLYLDIEGLLLNDKGKAYL YKQKLSPIPNKNVVEEYKEYLWNSNNSDISKAPNKFSIIETTYSDTSGKVIADLYFDDGQFYISKRYT FFFKKYDYYWIIYDYIVQNTGIKEK f269.nt (SEQ ID NO:279) ATGAATATTAGAAAATTGCTTTTTTGTATCTTTTTTATGAATATTTCTTTTCTTTTGTTTG CGGGAGATTACAAGGGCCTTGATTTTAAAATCAAGTTTTTAATCAATCTATTTATCGTGTCAAT AGTAATGTTTTTATTGAAGTTTCTCTTAGTAATGCGTCTGAGAGTGTTTTAACTTTAGAAATAGG CGATATTAATTCTTTTGGCTTTGATTTTGATGTTACTGATACCACCAATATTAAAGTTAAAAGAC CTATTGAATATGTTAAAAAGAGATCTAAAAATGTTGCAATTCCTGTTAGAAATATGAGCTTGAG ACCTAATGAAAAATTTTCTGTAGTTATTAACTTAAATCAATTTGTTAAGTTTAGTAAAGATGGA GTTTATTTTGTTAAGGGTATTTTTTTCCCAGACATTTCAGATCCATCTAAAGAAAAAGAATCCAA TATTATTACGCTTTTTTTGAATGATGGTTTTGATGAAAATCCAGGTAGCATAGACCTTGTTAATT TGTCTGAAAATAATGATATTCAAGATATCTTGAAAAAGAAAAAATTATCTCCCGATGAAATTGT TAAATATTTGTTAAAGGCATTGCAGCTTGGGAAAAAAGAAAAGTTCTTTTTATATCTTGATATT GAAGGTTTGTTATTAAATGACAAGGGCAAGGCATACCTTTATAAGCAAAAGTTATCACCTATTC CCAATAAAAATGTAGTTGAAGAGTATAAAGAATATTTGTGGAATTCTAATAATTCGGATATTTC AAAAGCACCAAATAAATTTTCTATTATTGAAACTACTTATTCTGATACTTCTGGCAAGGTGATT GCTGATTTATATTTTGACGATGGGCAATTTTATATTTCCAAAAGATATACTTTCTTCTTTAAAAA ATATGATTATTATTGGATAATTTATGATTACATTGTTCAAAATACTGGCATTAAGGAAAAGTAA t269.nt (SEQ ID NO:280) GGAGATTACAAGGGCCTTGATTTTAAAATCAAGTTTTTTAATCAATCTATTTATCGTGTCAATAG TAATGTTTTTATTGAAGTTTCTCTTAGTAATGCGTCTGAGAGTGTTTTAACTTTAGAAATAGGCG ATATTAATTCTTTTGGCTTTGATTTTGATGTTACTGATACCACCAATATTAAAGTTAAAAGACCT ATTGAATATGTTAAAAAGAGATCTAAAAATGTTGCAATTCCTGTTAGAAATATGAGCTTGAGAC CTAATGAAAAATTTTCTGTAGTTATTAACTTAAATCAATTTGTTAAGTTTAGTAAAGATGGAGT TTATTTTGTTAAGGGTATTTTTTTCCCAGACATTTCAGATCCATCTAAGAAAAAAGAATCCAATA TTATTACGCTTTTTTTGAATGATGGTTTTGATGAAAATCCAGGTAGCATAGACCTTGTTAATTTG TCTGAAAATAATGATATTCAAGATATCTTGAAAAAGAAAAAATTATCTCCCGATGAAATTGTTA AATATTTGTTAAAGGCATTGCAGCTTGGGAAAAAAGAAAAGTTCTTTTTATATCTTGATATTGA AGGTTTGTTATTAAATGACAAGGGCAAGGCATACCTTTATAAGCAAAAGTTATCACCTATTCCC AATAAAAATGTAGTTGAAGAGTATAAAGAATATTTGTGGAATTCTAATAATTCGGATATTTCAA AAGCACCAAATAAATTTTCTATTATTGAAACTACTTATTCTGATACTTCTGGCAAGGTGATTGCT GATTTATATTTTGACGATGGGCAATTTTATATTTCCAAAAGATATACTTTCTTCTTTAAAAAATA TGATTATTATTGGATAATTTATGATTACATTGTTCAAAATACTGGCATTAAGGAAAAGTAA f29.aa (SEQ ID NO:281) MNWLSFFYVLLFLLIFPFELQSNNKENIENLIKLHMLYDLTNNLSKELETINKIKNFDLEQHYLLITKY YLKIKKYKEANDFLKKINQKKIKNQKIKNEIISLKLRINEDNINEEEIKKILNNEKNIDVKIIYQIFSLIK FKNKJKLKLANKIKNIILTNYPKSIYSYKIKRNE t29.aa (SEQ ID NO:282) NNKENIENLIKLHMLYDLTNNLSKELETINKIKNFDLEQHYLLITKYYLKIKKYKEANDFLKKINQKK IKNQKIKNEIISLKLRINEDNINEEEIKKILNNEKNIDVKIIYQIFSLIKFKNKKLANKIKNIILTNYPKSIY SYKIKRNE f29.nt (SEQ ID NO:283) ATGAACTGGCTATCCTTTTTTTATGTTTTATTATTTTTATTAATTTTTCCTTTTGAATTACAGAGT AATAATAAAGAAAATATAGAAAATTTAATAAAGCTACATATGCTTTATGATTTAACCAATAACC TGTCAAAAGAATTAGAAACAATAAATAAAATTAAAAATTTTGACTTAGAACAACATTATCTGCT AATTACAAAATATTATCTAAAAATAAAAAAATATAAAGAAGCTAATGATTTTTTAAAAAAAATA AACCAAAAAAAGATCAAAAATCAAAAAATAAAAAACGAAATCATTTCGCTAAAATTAAGAATA AATGAAGATAATATTAATGAAGAAGAAATCAAAAAAATTTTAAATAACGAAAAAAATATAGAT GTCAAAATAATTTATCAAATATTCAGTCTTATAAAATTTAAAAATAAAAAATTAGCAAATAAAA TTAAAAACATAATACTAACAAACTATCCCAAAAGCATTTATTCTTATAAAATAAAAAGAAATGA ATAA t29.nt (SEQ ID NO:284) AATAATAAAGAAAATATAGAAAATTTAATAAAGCTACATATGCTTTATGATTTAACCAATAACC TGTCAAAAGAATTAGAAACAATAAATAAAATTAAAAATTTTGACTTAGAACAACATTATCTGCT AATTACAAAATATTATCTAAAAATAAAAAAATATAAAGAAGCTAATGATTTTTTAAAAAAAATA AACCAAAAAAAGATCAAAAATCAAAAAATAAAAAACGAAATCATTTCGCTAAAATTAAGAATA AATGAAGATAATATTAATGAAGAAGAAATCAAAAAAATTTTAAATAACGAAAAAAATATAGAT GTCAAAATAATTTATCAAATATTCAGTCTTATAAAATTTAAAAATAAAAAATTAGCAAATAAAA TTAAAAACATAATACTAACAAACTATCCCAAAAGCATTTATTCTTATAAAATAAAAAGAAATGA ATAA f290.aa (SEQ ID NO:285) MNSIYVIGKLLLTLFLIFFPFCYNLFAVNLAEINKLSEYAKSIVLIDFDTKRILYSKKPNLVFPPASLTKI VTIYTALIEAEKRNIKLKSIVPISDSASYYNAPPNSSLMFLEKGQIVNFEEILKGLSVSSGNDSSIAIAEF VVGNLNSFVNLMNINVLNLGLFNMHFVEPSGYSSENKITALDMAFFVKSYIEKFKFMLNIHSLKYFI YPKSRNLGTALSSKFLNLKQRNANLLIYDYPYSDGIKTGYIKESGLNLVATAKKGERRLIAVVLGVE KGINGFGEKMRSSIAKNLFEYGFNKYSKFPLIVKLKEKVYNGTVDTVALFSKEPFYYILTKDEFDKIN ISYTVDKLVAPLSGDMPVGRAMIFLENEKIGDVALFSGKVKRLGFWQGLYKSFINLFSREY t290.aa (SEQ ID NO:286) VNLAEINKLSEYAKSIVLIDFDTKRILYSKKPNLVFPPASLTKIVTIYTALIEAEKRNIKLKSIVPISDSA SYYNAPPNSSLMFLEKGQIVNFEEILKGLSVSSGNDSSIAIAEFVVGNLNSFVNLMNINVLNLGLFNM HFVEPSGYSSENKITALDMAFFVKSYIEKFKFMLNIHSLKYFIYPKSRNLGTALSSKFLNLKQRNANL LIYDYPYSDGIKTGYIKESGLNLVATAKKGERRLIAVVLGVEKGINGFGEKMRSSIAKINLFEYGFNK YSKFPLIVKLKEKVYNGTVDTVALFSKEPFYYILTKDEFDKINISYTVDKLVAPLSGDMPVGRAMIFL NEKIGDVALFSGKVKRLGFWQGLYKSFINLFSREY f290.nt (SEQ ID NO:287) ATGAATAGTATCTATGTTATTGGGAAATTGTTATTAACTTTATTTTTAATTTTTTTCCCGTTTTGT TATAATCTTTTTGCAGTTAATTTAGCTGAGATTAATAAATTATCAGAGTATGCAAAGTCAATAG TTTTAATAGATTTTGATACTAAGCGAATACTTTATTCTAAGAAGCCCAATTTGGTTTTTCCTCCA GCATCTCTTACAAAGATTGTTACAATTTATACAGCTTTAATTGAAGCTGAAAAGCGAAATATAA AATTAAAAAGCATAGTTCCTATTAGCGATTCTGCTTCATATTATAATGCACCCCCCAATTCTTCT TTGATGTTTTAGAAAAAGGTCAAATTGTTAATTTTGAAGAGATTTTAAAAGGACTTTCAGTTT CTTCGGGTAATGATTCTTCTATTGCAATTGCTGAGTTTGTAGTAGGCAATTTAAATAGCTTTGTT AATTTAATGAATATTAATGTTTTAAATTTAGGGCTTTTTAATATGCATTTTGTTGAACCTTCTGG ATATAGCAGCGAGAATAAGATTACAGCACTAGATATGGCTTTTTTTGTGAAATCTTATATAGAA AAGTTTAAATTTATGCTTAATATTCATTCTTTAAAGTATTTTATTTATCCAAAGAGTAGAAATTT AGGAACTGCTTTGTCATCAAAATTTTTAAACTTAAAACAAAGAAATGCTAATTTATTAATATAT GATTACCCTTATTCAGATGGCATTAAAACGGGATATATTAAGGAATCAGGCTTAAATCTTGTTG CTACTGCTAAAAAGGGTGAGAGAAGATTAATAGCAGTTGTATTGGGGGTTGAAAAAGGAATTA ATGGATTTGGAGAGAAAATGAGATCTTCGATTGCAAAAAATTTATTTGAATATGGATTTAATAA ATATTCTAAATTTCCTTTAATAGTAAAATTAAAAGAAAAAGTCTATAATGGTACAGTGGATACA GTTGCTCTTTTTTCTAAAGAGCCTTTTTATTATATTTTAACTAAAGATGAATTTGATAAAATTAA TATAAGTTATACTGTTGATAAATTGGTTGCTCCACTTAGTGGGGATATGCCTGTTGGGAGGGCT ATGATTTTTTTAGAAAATGAAAAAATAGGGGATGTTGCTTTGTTTAGTGGCAAGGTAAAAAGAT TAGGGTTTTGGCAAGGTCTTATAAGAGTTTTATAAATCTTTTTTCAAGAGAGTATTAA t290.nt (SEQ ID NO:288) GTTAATTTAGCTGAGATTAATAAATTATCAGAGTATGCAAAGTCAATAGTTTTAATAGATTTTG ATACTAAGCGAATACTTTATTCTAAGAAGCCCAATTTGGTTTTTCCTCCAGCATCTCTTACAAAG ATTGTTACAATTTATACAGCTTTAATTGAAGCTGAAAAGCGAAATATAAAATTAAAAAGCATAG TTCCTATTAGCGATTCTGCTTCATATTATAATGCACCCCCCAATTCTTCTTTGATGTTTTTAGAA AAAGGTCAAATTGTTAATTTTGAAGAGATTTTAAAAGGACTTTCAGTTTCTTCGGGTAATGATT CTTCTATTGCAATTGCTGAGTTTGTAGTAGGCAATTTAAATAGCTTTGTTAATTTAATGAATATT AATGTTTTAAATTTAGGGCTTTTTAATATGCATTTTGTTGAACCTTCTGGATATAGCAGCGAGAA TAAGATTACAGCACTAGATATGGCTTTTTTTGTGAAATCTTATATAGAAAAGTTTAAATTTATGC TTAATATTCATTCTTTAAAGTATTTTATTTATCCAAAGAGTAGAAATTTAGGAACTGCTTTGTCA TCAAAATTTTTAAACTTAAAACAAAGAAATGCTAATTTATTAATATATGATTACCCTTATTCAGA TGGCATTAAAACGGGATATATTAAGGAATCAGGCTTAAATCTTGTTGCTACTGCTAAAAAGGGT GAGAGAAGATTAATAGCAGTTGTATTGGGGGTTGAAAAAGGAATTAATGGATTTGGAGAGAAA ATGAGATCTTCGATTGCAAAAAATTTATTTGAATATGGATTTAATAAATATTCTAAATTTCCTTT AATAGTAAAATTAAAAGAAAAAGTCTATAATGGTACAGTGGATACAGTTGCTCTTTTTTCTAAA GAGCCTTTTTATTATATTTTAACTAAAGATGAATTTGATAAAATTAATATAAGTTATACTGTTGA TAAATTGGTTGCTCCACTTAGTGGGGATATGCCTGTTGGGAGGGCTATGATTTTTTTAGAAAAT GAAAAAATAGGGGATGTTGCTTTGTTTAGTGGCAAGGTAAAAAGATTAGGGTTTTGGCAAGGT CTTTATAAGAGTTTTATAAATCTTTTTTCAAGAGAGTATTAA f291.aa (SEQ ID NO:289) MNSYDFITALVPIILIIIGLGIIKKPAYYVIPISLIATVAIVIFYKNLGIVNTSLAMLEGALMGIWPIATVII AAIFTYKMSEDQKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPF FACLICLIMNTSSTAYGSVGIPITSLAQATNLDVNIVSSEIAFQLILPTLTIPFVLVILTGGGIKGLKGVF LLTLLSGMSMAISQVFISKTLGPELPAILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYI LIVTFIVLVSPLFNKIHEYLKTFQSTISIYPEANPLHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLT LKKMALSSFIIICIVAISRLMTHSGMIRDLANGISIITGKFGPLFSPLIGAIGTFLTGSDTVSNVLFGPLQT QMAENIGANPYWLAAANTTGATGGKMISPQNITIATTYAGLIGQEGKLLSKTIIYALYYILATGLLVY LV t291.aa (SEQ ID NO:290) QKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLICLIMNTS STAYGSVGIPITSLAQATNLDVNIVSSEIAFQLILPTLTIPFVLVILTGGGIKGLKGVFLLTLLSGMSMAI SQVFISKTLGPELPAILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYILIVTFIVLVSPLF NKIHEYLKTFQSTISIYPEANPLHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLTLKKMALSSFIIIC IVAISRLMTHSGMIRDLANGISIITGKFGPLFSPLIGAIGTFLTGSDTVSNVLFGPLQTQMAENIGANPY WLAAANTTGATGGKMISPQNITIATTTAGLIGQEGKLLSKTIIYALYYILATGLLVYLV f291.nt (SEQ ID NO:291) ATGAATTCTTATGATTTTATAACAGCTTTGGTACCAATAATCCTAATAATTATTGGACTTGGCAT AATAAAAAAGCCAGCTTACTATGTAATACCCATATCATTAATAGCCACCGTTGCTATAGTTATA TTTTATAAAAACTTGGGAATAGTAAACACAAGTCTTGCAATGCTTGAGGGCGCCTTAATGGGGA TATGGCCAATAGCAACTGTAATTATTGCTGCCATATTTACATACAAAATGTCAGAAGATCAAAA AGATATAGAAACTATTAAAAATATTTTATCAAACGTATCTTCTGATAGAAGAATTATAGTATTA CTAGTTGCATGGGGATTTGGAAATTTTTTAGAAGGAGTTGCTGGATATGGAACTGCTGTTGCAA TTCCTGTATCAATATTAATAGCAATGGGATTTGAACCATTTTTTGCCTGCTTAATCTGTTTAATA ATGAACACCTCATCAACCGCCTACGGATCTGTGGGAATCCCTATAACATCTTTAGCTCAAGCAA CTAACTTGGATGTTAACATTGTTTTCATCTGAGATTGCATTCCAACTAATACTTCCAACCTTAACA ATACCTTTTGTACTGGTAATTCTTACAGGAGGGGGCATTAAAGGATTAAAAGGAGTATTCCTTC TTACCTTACTCTCAGGAATGTCAATGGCAATATCTCAAGTATTTATATCAAAAACTTTGGGTCCA GAACTTCCTGCAATCCTTGGAAGCATTCTTTCTATGACAATAACAATAGTTTATGCAAGGTTTTT TGGAAATAAAGAAACTACTGAGCGCCAAAGCAAAAACACAATATCCTTATCAAAAGGAATTAT TGCCTGCTCACCCTACATTTTAATAGTAACTTTTATAGTGCTTGTATCTCCTCTTTTTAACAAAA TTCATGAATACCTAAAAACTTTTCAAAGCACTATTAGCATTTATCCAGAAGCAAATCCCTTACA CTTTAAATGGATTATCTCTCCGGGCTTCTTGATTATACTTGCAACAACAATATCCTATTCAATAC GGGGAGTTCCAATGTTAAAACAGCTAAAAATATTTACATTAACCTTGAAAAAAATGGCATTATC TTCCTTTATAATCATATGCATTGTTGCAATATCAAGATTAATGACACATAGTGGAATGATAAGA GATCTTGCTAATGGAATCTCAATAATAACAGGTAAATTTGGACCATTATTTAGCCCACTAATTG GAGCTATTGGGACATTTTTAACAGGAAGTGATACGGTTTCAAATGTTCTTTTTGGACCTTTACA AACACAAATGGCAGAAAATATTGGAGCAAATCCTTACTGGCTTGCAGCAGCAAATACAACAGG AGCAACTGGAGGGAAAATGATTTCTCCCCAAAACATCACAATAGCAACAACAACTGCTGGATT AATTGGACAAGAAGGCAAGCTTTTATCAAAAACAATAATTTATGCTTTATACTACATTTTAGCA ACAGGATTGCTAGTTTATTTAGTATAA t291.nt (SEQ ID NO:292) CAAAAAGATATAGAAACTATTAAAAATATTTTATCAAACGTATCTTCTGATAGAAGAATTATAG TATTACTAGTTGCATGGGGATTTGGAAATTTTTTAGAAGGAGTTGCTGGATATGGAACTGCTGT TGCAATTCCTGTATCAATATTAATAGCAATGGGATTTGAACCATTTTTTGCCTGCTTAATCTGTT TAATAATGAACACCTCATCAACCGCCTACGGATCTGTGGGAATCCCTATAACATCTTTAGCTCA AGCAACTAACTTGGATGTTAACATTGTTTCATCTGAGATTGCATTCCAACTAATACTTCCAACCT TAACAATACCTTTTGTACTGGTAATTCTTACAGGAGGGGGCATTAAAGGATTAAAAGGAGTATT CCTTCTTACCTTACTCTCAGGAATGTCAATGGCAATATCTCAAGTATTTATATCAAAAACTTTGG GTCCAGAACTTCCTGCAATCCTTGGAAGCATTCTTTCTATGACAATAACAATAGTTTATGCAAG GTTTTTTGGAAATAAAGAAACTACTGAGCGCCAAAGCAAAAACACAATATCCTTATCAAAAGG AATTATTGCCTGCTCACCCTACATTTTAATAGTAACTTTTATAGTGCTTGTATCTCCTCTTTTTAA CAAAATTCATGAATACCTAAAAACTTTTCAAAGCACTATTAGCATTTATCCAGAAGCAAATCCC TTACACTTTAAATGGATTATCTCTCCGGGCTTCTTGATTATACTTGCAACAACAATATCCTATTC AATACGGGGAGTTCCAATGTTAAAACAGCTAAAAATATTTACATTAACCTTGAAAAAAATGGCA TTATCTTCCTTTATAATCATATGCATTGTTGCAATATCAAGATTAATGACACATAGTGGAATGAT AAGAGATCTTGCTAATGGAATCTCAATAATAACAGGTAAATTTGGACCATTATTTAGCCCACTA ATTGGAGCTATTGGGACATTTTTAACAGGAAGTGATACGGTTTCAAATGTTCTTTTTGGACCTTT ACAAACACAAATGGCAGAAAATATTGGAGCAAATCCTTACTGGCTTGCAGCAGCAAATACAAC AGGAGCAACTGGAGGGAAAATGATTCTCCCCAAAACATCACAATAGCAACAACAACTGCTGGA TTAATTGGACAAG f296.aa (SEQ ID NO:293) MPSPIRVFFLVLLFIFIFNPVLIAMLFILFPFILILFSFLGVFRIYFTRDYSYSRSREFEFYKLSFLLMAKLL SILGTVTGEQLNYVNFIINSLNLSERGKSELYTIFHSAITKNNNADKILYTLKLGYFQHKDLFIWLFAT LKEINRLSRYKNLEAEKFISYVGVFLELESDGYEAYKDINIKIVNPYSVLGLTYSASDDEVKKAYKSL VIKYHPDKFANDPVRQKDANDKFIKIQDAYEKICKERNIR t296.aa (SEQ ID NO:294) IYFTRDYSYSRSREFEFYLLSFKLMAKLLSILGTVTGEQLNYVNFIINSLNLSERGKSELYTIFHSAITK NNNADKILYTLKLGYFQHKDLFIWLFATLKEINRLSRYKNLEAEKFISYVGVFLELESDGYEAYKDI NIKIVNPYSVLGLTYSASDDEVKKAYKSLVIKYHPDKFANDPVRQKDANDKFIKIQDAYEKICKEPN IR f296.nt (SEQ ID NO:295) ATGCCAAGCCCAATTAGAGTGTTTTTTTTAGTGTTGTTGTTTATTTTTATTTTTAATCCCGTTTTA ATAGCAATGCTTTTTATTTTATTTCCTTTTATTTTGATATTATTTAGTTTTTTAGGTGTTTTTAGA ATATACTTTACAAGGGATTACTCATATTCTAGATCTAGAGAGTTTGAATTTTATAAACTTTCTTT TTTATTAATGGCTAAATTGCTATCTATTTTAGGAACTGTAACTGGGGAGCAGCTAAATTATGTC AATTTTATTATCAATTCTTTGAATTTGTCTGAACGTGGTAAATCAGAATTGTATACCATTTTTCA TTCTGCTATTACTAAAAATAATAATGCTGATAAAATTTTATATACCCTTAAGCTTGGTTATTTTC AGCACAAAGATCTTTTTATATGGCTTTTTGCCACTCTTAAAGAAATTAACAGGCTCTAGGTAT AAAAATTTAGAAGCTGAAAAATTTATTTCTTATGTTGGTGTTTTTTTAGAACTTGAATCTGATGG TTATGAAGCTTATAAAGATATTAATATTAAAATTGTAAATCCTTATAGTGTTTTGGGGTTAACA TATAGTGCTAGCGATGATGAGGTTAAAAAGGCGTATAAAAGCCTTGTTATAAAATATCATCCTG ATAAGTTTGCAAATGATCCTGTAAGACAAAAAGATGCAAATGATAAATTTATAAAAATTCAAG ATGCTTATGAAAAAATTTGCAAGGAAAGAAATATAAGGTAA t296.nt (SEQ ID NO:296) ATATACTTTACAAGGGATTACTCATATTCTAGATCTAGAGAGTTTGAATTTTATAAACT TTCTTTTTTATTAATGGCTAAATTGCTATCTATTTTAGGAACTGTAACTGGGGAGCAGCTAAATT ATGTCAATTTTATTATCAATTCTTTGAATTTGTCTGAACGTGGTAAATCAGAATTGTATACCATT TTTCATTCTGCTATTACTAAAAATAATAATGCTGATAAAATTTTATATACCCTTAAGCTTGGTTA TTTTCAGCACAAAGATCTTTTTATATGGCTTTTTGCCACTCTTAAAGAAATTAACAGGCTTTCTA GGTATAAAAATTTAGAAGCTGAAAAATTTATTTCTTATGTTGGTGTTTTTTTAGAACTTGAATCT GATGGTTATGAAGCTTATAAAGATATTAATATTAAAATTGTAAATCCTTATAGTGTTTTGGGGT TAACATATAGTGCTAGCGATGATGAGGTTAAAAAGGCGTATAAAAGCCTTGTTATAAAATATCA TCCTGATAAGTTTGCAAATGATCCTGTAAGACAAAAAGATGCAAATGATAAATTTATAAAAATT CAAGATGCTTATGAAAAAATTTGCAAGGAAAGAAATATAAGGTAA f3.aa (SEQ ID NO:297) MKKKNLSIYMIMLISLLSCNTSDPNELTRKKMQDKNVKILGFLEKIQADNKEIVEKHIEKKEKQMVQ AASVAPINVESNFPYYLQEEIEIKEEELVPNTDEEKKAEKAISDGSLEFAKLVDDENKLKNESAQLES SFNNVYKEILELADLIQAEVHVAGRINSYIKKRKTTKEKEYKKREIKNKIEKQALIKLFNQLLEKRGD IENLHTQLNSGLSERASAKYFFEKAKETLKAAITERLNNKRKNRPWWARRTHSNLAIQAKNEAEDA LNQLSTSSFRILEAMKIKEDVKQLLEEVKSFLDSSKSKIFSSGDRLYDFLETSK t3.aa (SEQ ID NO:298) NELTRKKMQDKNVKILGFLEKIQADNKEIVEKHIEKKEKQMVQAASVAPINVESNFPYYLQEEIEIK EEELVPNTDEEKKAEKAISDGSLEFAKLVDDENKLKNESAQLESSFNNVYKEILELADLIQAEVHVA GRINSYIKKRKTTKEKEYKKREIKNKIEKQALIKLFNQLLEKRGDIENLHTQLNSGLSERASAKYFFE KAKETLKAAITERLNNKRKNRPWWARRTRSNLAIQAKNEAEDALNQLSTSSFRILEAMKIKEDVKQ LLEEVKSFLDSSKSKIFSSGDRLYDFLETSK f3.nt (SEQ ID NO:299) ATGAAAAAAAAAAATTTATCAATTTACATGATAATGCTAATAAGTTTATTATCATGTAATACAA GTGACCCCAATGAATTAACTCGTAAAAAAATGCAAGACAAGAACGTGAAAATTTTAGGATTTTT AGAGAAAATTCAAGCAGATAATAAAGAAATTGTTGAAAAACATATAGAAAAAAAAGAAAAAC AAATGGTGCAGGCTGCTTCTGTAGCACCTATTAATGTAGAGAGTAATTTCCCATATTATCTTCA AGAAGAAATAGAGATAAAAGAAGAAGAGTTGGTTCCAAATACTGATGAAGAAAAGAAGGCAG AGAAGGCAATTAGCGATGGGAGTCTTGAATTTGCTAAATTAGTTGATGATGAAAATAAACTTAA AAATGAATCTGCGCAATTAGAATCTAGTTTTAATAATGTTTATAAAGAAATCTTAGAACTTGCA GATTTAATACAAGCAGAGGTGCATGTTGCAGGAAGGATAAATAGCTATATAAAAAAAAGAAAG ACCACTAAAGAAAAAGAATATAAGAAGAGAGAAATTAAGAATAAGATAGAAAAACAGGCTCT AATTAAGTTGTTCAATCAGTTATTAGAAAAAAGAGGCGATATTGAAAATCTTCATACTCAATTA AATAGTGGACTTAGCGAGAGAGCATCTGCAAAATACTTTTTTGAGAAAGCCAAAGAAACTTTA AAAGCTGCTATTACTGAAAGATTAAATAACAAACGTAAAAATCGGCCATGGTGGGCAAGAAGA ACACATAGTAATTTAGCAATACAGGCAAAAAATGAGGCAGAGGATGCTTTAAACCAATTAAGT ACTTCTTCTTTTAGGATACTTGAAGCAATGAAAATAAAGGAAGATGTAAAACAGCTTCTTGAAG AAGTAAAATCTTTTCTAGATTCTTCAAAGAGCAAAATCTTTTCTAGTGGCGATAGATTATATGA TTTTTTAGAGACGAGTAAATAA t3.nt (SEQ ID NO:300) AATGAATTAACTCGTAAAAAAATGCAAGACAAGAACGTGAAAATTTTAGGATTTTTAGAGAAA ATTCAAGCAGATAATAAAGAAATTGTTGAAAAACATATAGAAAAAAAAGAAAAACAAATGGTG CAGGCTGCTTCTGTAGCACCTATTAATGTAGAGAGTAATTTCCCATATTATCTTCAAGAAGAAA TAGAGATAAAAGAAGAAGAGTTGGTTCCAAATACTGATGAAGAAAAGAAGGCAGAGAAGGCA ATTAGCGATGGGAGTCTTGAATTTGCTAAATTAGTTGATGATGAAAATAAACTTAAAAATGAAT CTGCGCAATTAGAATCTAGTTTTAATAATGTTTATAAAGAAATCTTAGAACTTGCAGATTTAAT ACAAGCAGAGGTGCATGTTGCAGGAAGGATAAATAGCTATATAAAAAAAAGAAAGACCACTAA AGAAAAAGAATATAAGAAGAGAGAAATTAAGAATAAGATAGAAAAACAGGCTCTAATTAAGTT GTTCAATCAGTTATTAGAAAAAAGAGGCGATATTGAAAATCTTCATACTCAATTAAATAGTGGA CTTAGCGAGAGAGCATCTGCAAAATACTTTTTTGAGAAAGCCAAAGAAACTTTAAAAGCTGCTA TTACTGAAAGATTAAATAACAAACGTAAAAATCGGCCATGGTGGGCAAGAAGAACACATAGTA ATTTAGCAATACAGGCAAAAAATGAGGCAGAGGATGCTTTAAACCAATTAAGTACTTCTTCTTT TAGGATACTTGAAGCAATGAAAATAAAGGAAGATGTAAAACAGCTTCTTGAAGAAGTAAAATC TTTTCTAGATTCTTCAAAGAGCAAAATCTTTTCTAGTGGCGATAGATTATATGATTTTTTAGAGA CGAGTAAATAA f30.aa (SEQ ID NO:301) MNKKILTLLVLILSISSVLMLSKSITKKSKYKIIRDYFINSNYVLVKIENKDLKFTISKPIYDKKLNNYF FKGQTTSHFLISNNVDIAINTSPYEVKQNMFFPKGLYIYNKKMISKQINNYGEIVIKHNKIILNPKEDEI ENCDYGFSGFFVLIKNGKYKKNFKETRHPRTIIGTDKNNKHLFLVTIEGRGVNNSKGASLNEAIDFA LSYGMTNAINLDGGGSSTLVVKSNNAPYKLNFTANIFGQERPVPFHLGIKLPN t30.aa (SEQ ID NO:302) LSKSITKKSKYKIIRDYFINSNYVLVKIENKDLKFTISKPIYDKKLNNYFFKGQTTSHFLISNNVDIAIN TSPYEVKQNMFFPKGLYIYNKKMISKQINNYGEIVIKHNKIILNPKEDEIENCDYGFSGFFVLIKNGK YKKNFKETRHPRTIIGTDKNNKHLFLVTIEGRGVNNSKGASLNEAIDFALSYGMTNAINLDGGGSST LVVKSNNAPYKLNFTANIFGQERPVPFHLGIKLPN f30.nt (SEQ ID NO:303) ATGAATAAAAAAATATTAACACTGCTAGTATTGATTTTAAGTATTTCATCAGTACTAAT GCTGTCCAAATCAATCACCAAAAAATCCAAATACAAAATTATTAGGGATTATTTCATAAACAGC AATTATGTTCTGGTGAAAATTGAAAATAAAGATCTAAAATTTACCATATCAAAACCTATTTACG ACAAAAAGCTAAATAATTACTTCTTTAAAGGCCAAACAACAAGCCATTTCTTAATTTCTAACAA TGTTGACATTGCAATTAACACAAGTCCATACGAAGTTAAACAAAACATGTTTTTCCCAAAAGGA CTATACATATATAATAAAAAAATGATTTCAAAACAAATAAATAACTACGGAGAGATTGTAATAA AGCACAACAAAATTATATTAAATCCCAAGGAAGACGAAATAGAAAACTGCGATTATGGATTTA GCGGATTTTTTGTTTTAATCAAAAACGGAAAGTATAAAAAAAATTTTAAAGAAACAAGGCACCC AAGAACAATAATAGGAACTGATAAAAATAACAAGCATTTATTTCTTGTTACAATAGAAGGAAG GGGTGTCAATAATAGCAAAGGGGCCTCTCTTAATGAAGCTATTGATTTTGCATTAAGCTACGGC ATGACTAACGCTATTAATCTAGACGGGGGGGGCTCAAGCACTCTTGTTGTAAAATCAAATAACG CTCCTTACAAATTAAACTTCACAGCAAACATCTTTGGACAGGAAAGACCTGTCCCATTTCATTT AGGAATAAAACTTCCTAATTGA t30.nt (SEQ ID NO:304) CTGTCCAAATCAATCACCAAAAAATCCAAATACAAAATTATTAGGGATTATTTCATAAACAGCA ATTATGTTCTGGTGAAAATTGAAAATAAAGATCTAAAATTTACCATATCAAAACCTATTTACGA CAAAAAGCTAAATAATTACTTCTTTAAAGGCCAAACAACAAGCCATTTCTTAATTTCTAACAAT GTTGACATTGCAATTAACACAAGTCCATACGAAGTTAAACAAAACATGTTTTTCCCAAAAGGAC TATACATATATAATAAAAAAATGATTTCAAAACAAATAAATAACTACGGAGAGATTGTAATAA AGCACAACAAAATTATATTAAATCCCAAGGAAGACGAAATAGAAAACTGCGATTATGGATTTA GCGGATTTTTTGTTTTAATCAAAAACGGAAAGTATAAAAAAAATTTTAAAGAAACAAGGCACCC AAGAACAATAATAGGAACTGATAAAAATAACAAGCATTTATTTCTTGTTACAATAGAAGGAAG GGGTGTCAATAATAGCAAAGGGGCCTCTCTTAATGAAGCTATTGATTTTGCATTAAGCTACGGC ATGACTAACGCTATTAATCTAGACGGGGGGGGCTCAAGCACTCTTGTTGTAAAATCAAATAACG CTCCTTACAAATTAAACTTCACAGCAAACATCTTTGGACAGGAAAGACCTGTCCCATTTCATTT AGGAATAAAACTTCCTAATTGA f308.aa (SEQ ID NO:305) MQLLKNKYPFKRALLDLFLVYAIVYLASPFVNVNSEFWNVDENHFYFWISRSFLIIFIIYFFK LTSSYDDFRVEFFIPKFKFIFLWDSVLIFIKTILIAMIVIFLIAFLLEYLLPESVLVYYFQNNAGFNWKISS KKAFFLMTFTSFFTGAFEELFYRAFVITKFTQMGFPVVATAILSSMFFAYGHLYYGILGFLVTFILGIF FAFTYLRYKNVYYVIFIHSFYNIIVSSLLLFLN t308.aa (SEQ ID NO:306) NSEFWNVDENHFYFWISRSFLIIFIIYFFKLTSSYDDFRVEFFIPKFKFIFLWDSVLIFIKTILIAMIVIFLI AFLLEYLLPESVLVYYFQNNAGFNWKISSKKAFFLMTFTSFFTGAFEELFYRAFVITKFTQMGFPVV ATAILSSMFFAYGHLYYGILGFLVTFILGIFFAFTYLRYKNVYYVIFIHSFYNIIVSSLLLFLN f308.nt (SEQ ID NO:307) ATGCAATTGTTAAAAAATAAATATCCATTCAAGCGGGCTTTGCTTGATCTTTTTTTGGTCTATGC TATTGTTTATTTGGCATCTCCTTTTGTAAATGTTAATTCAGAATTTTGGAATGTTGATGAAAATC ATTTTTATTTTTGGATTTCAAGATCTTTTTTAATTATTTTTATAATTTATTTTTTTAAACTTACCA GTTCTTATGATGATTTTAGAGTAGAGTTTTTTATTCCTAAATTTAAATTTATTTTTCTTTGGGATT CTGTTTTAATTTTTATTAAAACAATATTGATTGCAATGATAGTCATTTTTTTAATAGCTTTTTTGC TTGAATATTTGTTGCCAGAATCGGTACTTGTCTATTATTTTCAAAACAATGCTGGATTTAATTGG AAGATTAGCAGTAAAAAAGCATTTTTTTTAATGACTTTTACCTCTTTTTTTACAGGAGCTTTTGA AGAACTTTTTTACAGGGCTTTTGTTATTACTAAGTTTACACAAATGGGATTTCCTGTTGTAGCTA CCGCCATTCTTAGTAGTATGTTTTTTGCTTATGGGCATTTATATTATGGAATTTTAGGATTTTTG GTTACATTTATATTAGGGATATTTTTTGCTTTTACTTATTTAAGGTATAAAAATGTATATTATGT GATTTTTATACATAGTTTTTATAATATTATTGTTAGCAGCTTGTTGCTTTTTTTGAATTAA t308.nt (SEQ ID NO:308) AATTCAGAATTTTGGAATGTTGATGAAAATCATTTTTATTTTTGGATTTCAAGATCTTTT TTAATTATTTTTATAATTTATTTTTTTAAACTTACCAGTTCTTATGATGATTTTAGAGTAGAGTTT TTTATTCCTAAATTTAAATTTATTTTTCTTTGGGATTCTGTTTTAATTTTTATTAAAACAATATTG ATTGCAATGATAGTCATTTTTTTAATAGCTTTTTTGCTTGAATATTTGTTGCCAGAATCGGTACT TGTCTATTATTTTCAAAACAATGCTGGATTTAATTGGAAGATTAGCAGTAAAAAAGCATTTTTTT TAATGACTTTTACCTCTTTTTTTACAGGAGCTTTTGAAGAACTTTTTTACAGGGCTTTTGTTATT ACTAAGTTTACACAAATGGGATTTCCTGTTGTAGCTACCGCCATTCTTAGTAGTATGTTTTTTGC TTATGGGCATTTATATTATGGAATTTTAGGATTTTTGGTTACATTTATATTAGGGATATTTTTTG CTTTTACTTATTTAAGGTATAAAAATGTATATTATGTGATTTTTATACATAGTTTTTATAATATT ATTGTTAGCAGCTTGTTGCTTTTTTTGAATTAA f31.aa (SEQ ID NO:309) MKKYLFFILFLISSNNLIVSYPLSFGGGFSYQFTNYTDKTGATKFAPNFTRADHGINLNLFFDANYVL FEMSYKEAFVVTHNGRYFSLGLYGTYPMVFKEQVRMLFPLIGFKYAFDLSSNNFNLFFLSMGLAAD LFIPDLDGLYIRPLFMLSISPFSNYKNFSGLTTEIMLGFNIGWRFFN t31.aa (SEQ ID NO:310) IVSYPLSFGGGFSYQFTNYTDKTGATKFAPNFTRADHGINLNLFFDANYVLFEMSYKEAFVVTHNG RYFSLGLYGTYPMVFKEQVRMLFPLIGFKYAFDLSSNNFNLFFLSMGLAADLFIPDLDGLYIRPLFML SISPFSNYKNFSGLTTEIMLGFNIGWRFFN f31.nt (SEQ ID NO:311) ATGAAGAAATATCTTTTTTTTATTTTATTTCTCATCTCTTCTAATAATTTAATTGTTTCTTATCCA CTTTCTTTTGGTGGAGGTTTTTCTTATCAATTTACTAATTATACTGATAAAACAGGCGCCACTAA ATTTGCTCCAAATTTTACCAGAGCAGATCATGGGATTAATTTGAATTTATTTTTTGATGCAAATT ATGTACTTTTTGAAATGTCTTACAAAGAGGCTTTTGTTGTTACTCACAATGGGAGATATTTCTCG CTTGGGCTTTATGGAACATATCCAATGGTTTTCAAAGAGCAGGTTAGAATGCTTTTCCCATTAA TTGGGTTTAAATATGCTTTTGATTTAAGCTCTAATAACTTCAATCTCTTTTTTTTAAGCATGGGG CTTGCTGCTGATCTTTTTATTCCCGATCTTGATGGTTTATATATTAGGCCTTTGTTTATGCTTTCT ATTTCTCCATTTTCTAATTATAAAAATTTTTCTGGGTTAACAACTGAGATTATGCTTGGATTTAA TATCGGTTGGAGATTTTTCAATTAG t31.nt (SEQ ID NO:312) ATTGTTTCTTATCCACTTTCTTTTGGTGGAGGTTTTTCTTATCAATTTACTAATTATACTGATAAA ACAGGCGCCACTAAATTTGCTCCAAATTTTACCAGAGCAGATCATGGGATTAATTTGAATTTAT TTTTTGATGCAAATTATGTACTTTTGAAATGTCTTACAAAGAGGCTTTTGTTGTTACTCACAAT GGGAGATATTTCTCGCTTGGGCTTTATGGAACATATCCAATGGTTTTCAAAGAGCAGGTTAGAA TGCTTTTCCCATTAATTGGGTTTAAATATGCTTTTGATTTAAGCTCTAATAACTTCAATCTCTTTT TTTTAAGCATGGGGCTTGCTGCTGATCTTTTTATTCCCGATCTTGATGGTTTATATATTAGGCCT TTGTTTATGCTTTCTATTTCTCCATTTTCTAATTATAAAAATTTTTCTGGGTTAACAACTGAGATT ATGCTTGGATTTAATATCGGTTGGAGATTTTTCAATTAG f939.aa (SEQ ID NO:313) MKQKYENYFKKRLILNLLIFLLLACSSESIFSQLGNLQKIKHEYNILGSSSPRGISLVGETLYIAAMHLF KKENGKIEKIDLSNSYEFINDIVNISGKTYLLAQNKEEELEVCELNGKDWTLKFKKPLKAYKFLKSV GRDGVKEAYILAIDKNNREKIFDLQGSDKTPPQATENDKFYQISNEENLITGNSLKIWQMNNNTYTN IDYQQAKEIMPIIKTSIRGSSEVLVMTGGYNNLDTKFKVYSNTNNYTTPIFIQDEVGEFSSYFAREFND AILIGSNNGFAEFTKNKEGIFALRAPSKSVEPGAYNGSQLSKTGLNDIIPVSNNTIYILTQGKGLWKLE NRKLTKE f939.aa (SEQ ID NO:314) CSSESIFSQLGNLQKIKHEYNILGSSSPRGISLVGETLYIAAMHLFKKENGKIEKIDLSNSYEFINDIVNI SGKTYLLAQNKEEELEVCELNGKDWTLKFKKPLKAYKFLKSVGRDGVKEAYILAIDKNNREKTIDL QGSDKTPPQATENDKFYQISNEENLITGNSLKIWQMNNNTYTNIDYQQAKEIMPIIKTSIRGSSEVLV MTGGYNNLDTKFKVYSNTNNYTTPIFIQDEVGEFSSYFAREFNDAILIGSNNGFAEFTKNKEGIFALR APSKSVEPGAYNGSQLSKTGLNDIIPVSNNTIYILTQGKGLWKLENR KLTKE f939.nt (SEQ ID NO:315) ATGAAACAAAAATACGAAAACTATTTTAAAAAAAGATTAATTTTAAACCTATTAATATTTTTAC TACTAGCATGCTCAAGCGAATCCATATTTTCACAATTAGGAAATCTGCAAAAAATAAAACATGA ATACAATATTTTGGGCAGTTCAAGTCCAAGAGGAATTTCTCTAGTAGGAGAAACTCTCTACATT GCAGCCATGCATTTATTTAAAAAAGAAAACGGCAAGATTGAAAAAATTGATTTGAGCAATTCTT ATGAGTTTATAAACGACATTGTAAATATATCTGGAAAAACCTATCTTTTAGCGCAAAACAAAGA AGAAGAATTAGAAGTTTGCGAGCTAAATGGAAAAGATTGGACATTAAAATTTAAAAAACCGCT AAAAGCATATAAATTCTTAAAATCCGTAGGAAGAGATGGCGTAAAAGAAGCATATATTTTAGC TATAGATAAAAATAATCGTGAGAAAATTTTTGATCTACAAGGATCTGACAAAACACCACCACAA GCTACTGAAAATGACAAATTTTATCAAATATCAAATGAAGAAAACTTAATTACAGGAAATTCAC TCAAAATATGGCAAATGAATAACAATACATACACAAACATAGACTATCAACAGGCCAAAGAAA TAATGCCTATCATTAAAACAAGCATTAGGGGCTCTTCTGAAGTTTTAGTAATGACTGGTGGTTA CAATAATTTAGATACAAAATTTAAAGTTTACTCAAATACAAATAATTACACAACGCCAATATTT ATTCAAGACGAAGTAGGCGAATTTAGCAGCTACTTTGCAAGAGAATTTAATGATGCGATATTAA TCGGAAGTAATAATGGATTTGCAGAATTTACAAAAAATAAAGAAGGAATTTTTGCCCTACGGGC ACCCTCAAAATCTGTAGAACCTGGAGCTTATAACGGATCTCAGCTAAGCAAAACAGGCCTTAAT GATATTATTCCTGTATCAAACAACACGATTTACATATTAACTCAGGGCAAGGGTTTGTGGAAAT TGGAAAACAGAAAATTAACTAAAGAATAA t939.nt (SEQ ID NO:316) TGCTCAAGCGAATCCATATTTTCACAATTAGGAAATCTGCAAAAAATAAAACATGAATACAATA TTTTGGGCAGTTCAAGTCCAAGAGGAATTTCTCTAGTAGGAGAAACTCTCTACATTGCAGCCAT GCATTTATTTAAAAAAGAAAACGGCAAGATTGAAAAAATTGATTTGAGCAATTCTTATGAGTTT ATAAACGACATTGTAAATATATCTGGAAAAACCTATCTTTTAGCGCAAAACAAAGAAGAAGAA TTAGAAGTTTGCGAGCTAAATGGAAAAGATTGGACATTAAAATTTAAAAAACCGCTAAAAGCA TATAAATTCTTAAAATCCGTAGGAAGAGATGGCGTAAAAGAAGCATATATTTTAGCTATAGATA AAAATAATCGTGAGAAAATTTTTGATCTACAAGGATCTGACAAAACACCACCACAAGCTACTGA AAATGACAAATTTTATCAAATATCAAATGAAGAAAACTTAATTACAGGAAATTCACTCAAAATA TGGCAAATGAATAACAATACATACACAAACATAGACTATCAACAGGCCAAAGAAATAATGCCT ATCATTAAAACAAGCATTAGGGGCTCTTCTGAAGTTTTAGTAATGACTGGTGGTTACAATAATT TAGATACAAAATTTAAAGTTTACTCAAATACAAATAATTACACAACGCCAATATTTATTCAAGA CGAAGTAGGCGAATTTAGCAGCTACTTTGCAAGAGAATTTAATGATGCGATATTAATCGGAAGT AATAATGGATTTGCAGAATTTACAAAAAATAAAGAAGGAATTTTTGCCCTACGGGCACCCTCAA AATCTGTAGAACCTGGAGCTTATAACGGATCTCAGCTAAGCAAAACAGGCCTTAATGATATTAT TCCTGTATCAAACAACACGATTTACATATTAACTCAGGGCAAGGGTTTGTGGAAATTGGAAAAC AGAAAATTAACTAAAGAATAA f739.aa (SEQ ID NO:317) MQSGLKIKLILFFCCFACSCDINYPEIKELDYKINYYFTENRLDYSMSFDFAIKVINSKDVFK LSIENKNTNEFIQVINNNYSSFFIDSSLGKDILYCKDLRFNFFDKTFEDFTSCVRLFDKGMRVYNRELV ISLGMSKYDLDDVHNYVYKSKDMEMLNKLSNSKVFFVKTYKDKLHPVSSVVRIDSIDILEIDKAFD NYISFYYVEKNSNLFFKVG t739.aa (SEQ ID NO:318) CCFACSCDINYPEIKELDYKINYYFTENRLDYSMSFDFAIKVINSKDVFKLSIENKNTNEFIQVINNNY SSFFIDSSLGKDILYCKDLRFNFFDKTFEDFTSCVRLFDKGMRVYNRELVISLGMSKYDLDDVHNYV YKSKDMEMLNKLSNSKVFFVKTYKDKLHPVSSVVRIDSIDILEIDKAFDNYISFYYVEKNSNLFFKV G f739.nt (SEQ ID NO:319) ATGCAGAGCGGATTAAAAATTAAATTAATATTGTTTTTTTGTTGTTTTGCTTGTTCTTGCGACAT AAATTATCCGGAGATAAAAGAGCTTGATTATAAGATAAATTATTATTTTACTGAAAATCGCTTA GATTACTCTATGAGTTTTGATTTTGCAATTAAAGTTATAAATTCAAAAGATGTTTTTAAATTATC AATAGAGAATAAGAACACTAATGAGTTTATTCAAGTGATTAATAATAATTATAGCTCTTTTTTT ATTGATTCTAGCCTTGGAAAGGATATTCTATATTGTAAGGATTTGAGGTTTAATTTTTTTGATAA AACTTTTGAAGATTTTACCTCATGTGTTCGTCTTTTTGATAAGGGCATGAGAGTATACAATAGA GAGCTTGTTATTTCTTTGGGTATGTCAAAATATGATTTAGATGATGTTCACAATTATGTATATAA GTCTAAAGATATGGAAATGTTAAACAAGTTAAGCAATTCCAAAGTATTTTTTGTTAAAACTTAT AAAGACAAACTACATCCGGTCTCTTCAGTTGTTAGAATTGATTCAATAGATATTCTAGAGATTG ATAAAGCATTTGATAATTACATAAGTTTTTATTATGTCGAAAAAAATTCAAATCTTTTTTTTAAA GTTGGCTGA t739.nt (SEQ ID NO:320) TGTTGTTTTGCTTGTTCTTGCGACATAAATTATCCGGAGATAAAAGAGCTTGATTATAAGATAA ATTATTATTTTACTGAAAATCGCTTAGATTACTCTATGAGTTTTGATTTTGCAATTAAAGTTATA AATTCAAAAGATGTTTTTAAATTATCAATAGAGAATAAGAACACTAATGAGTTTATTCAAGTGA TTAATAATAATTATAGCTCTTTTTTTATTGATTCTAGCCTTGGAAAGGATATTCTATATTGTAAG GATTTGAGGTTTAATTTTTTTGATAAAACTTTTGAAGATTTTACCTCATGTGTTCGTCTTTTTGA AAMGGGCATGAGAGTATACAATAGAGAGCTTGTTATTTCTTTGGGTATGTCAAAATATGATTTA GATGATGTTCACAATTATGTATATAAGTCTAAAGATATGGAAATGTTAAACAAGTTAAGCAATT CCAAAGTATTTTTTGTTAAAACTTATAAAGACAAACTACATCCGGTCTCTTCAGTTGTTAGAATT GATTCAATAGATATTCTAGAGATTGATAAAGCATTTGATAATTACATAAGTTTTTATTATGTCG AAAAAAATTCAAATCTTTTTTTTAAAGTTGGCTGA f742.aa (SEQ ID NO:321) MNKKHTNFSVLLLLIFLLILSFGGFGYYIYQSKLNDKNREIMLNEVKNSVIDRNYKKAYSVA KLLQDKYPQNEDIAMLTNTLAEIANSSPFESKDLQRDSANQILDKIKGQDNTKTNVNENFDIAFNNR YIKDSTITENYSDRNDDVGIEDEDISEFKKSKIPEKIKPNTNPKEEDQIIQSPNPKLSVNDQKNLFNLEK LKKNLSGKSNSENILNDSQKIENDKQNTNLSKEKNSENILKTPDNSKYSNNNNTTSLKKISSNSQKES ELSPPSQTIIGKIYRPYSYLIKKELYEILDDINTGRVTLGKNRLKELIKKGLSNKFQKVNELIENSKNKE ASNLLLTLIKKDIEPNLINIPKDPYKKEIFQLDKEDKKPQYLEDLKSKVHSIKPIDLENTKSRQQAIKD LNEFLKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFLKNNPNDAQ ASKTLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFLKNNPNDAQASKTLAQANKIQH LEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFXKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPI DLENTKSRQQAIKDLNEFXKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIK DLNEFLKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFXKNNPNDA QASKTLAQAYENNGDLLKAENAYEKIIKLTNTQEDHYKLGIIRFKLKKYEHSIESFDQTIKLDPKHKK ALHNKGIALMMLNKNKKAIESFEKAIQIDKNYGTAYYQKGIAEEKNGDMQQAFASFKNAYNLDKN PNYALKAGIVSNNLGNFKQSEEYLNFFNANAKKPNEIAIYNLSIAKFENNKLEESLETINKAIDLNPE KSEYLYLKASINLKKENYQNAISLYSLVIEKNPENTSAYINLAKAYEKSGNKSQAISTLEKIINKNNKL ALNNLGILYKKEKNYQKAIEIFEKAIINSDIEAKYNLATTLIEINDNTRAKDLLREYTKLKPNNPEALH ALGIIEYNENNNDQTLRELIKKFPNYKKNENIKKIIGI t742.aa (SEQ ID NO:322) KLNDKNREIMLNEVKNSVIDRNYKKAYSVAKLLQDKYPQNEDIAMLTNTLAEIANSSPFES KDLQRDSANQILDKIKGQDNTKTNVNENFDIAFNNRYIKDSTITENYSDRNDDVGIEDEDTSEFKKSK IPEKIKPNTNPKEEDQIIQSPNPKLSVNDQKNLFNLEKLKKNLSGKSNSENILNDSQKIENDKQNTNLS KEKNSENILKTPDNSKYSNNNTTSLKKISSNSQKESELSPPSQTIIGKIYRPYSYLIKKELYEILDDINT GRVTLGKNRLKELIKKGLSNKFQKVNELIENSKNKEASNLLLTLIKKDIEPNLINIPKDPYKKEIFQLD KEDKKPQYLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFLKNNPNDAQASKTLAQANKIQHLEDLK SKVHSIKPIDLENTKSRQQAIKDLNEFLKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPIDLENT KSRQQAIKDLNEFLKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEF XKNNPNDAQASKTLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFXKNNPNDAQASK TLAQANKIQHLEDLKSKVHSIKPIDLENTKSRQQAIKDLNEFLKNNPNDAQASKTLAQANKIQHLED LKSKVHSIKPIDLENTKSRQQAIKDLNEFXKNNPNDAQASKTLAQAYENNGDLLKAENAYEKIIKLT NTQEDHYKLGIIRFKLKKYEHSIESFDQTIKLDPKHKKALHNKGIALMMLNKNKKAIESFEKAIQIDK NYGTAYYQKGIAEEKNGDMQQAFASFKNAYNLDKNPNYALKAGIVSNNLGNFKQSEEYLNFFNAN AKKPNEIAIYNLSIAKFENNKLEESLETINKAIDLNPEKSEYLYLKASINLKKENYQNAISLYSLVIEKN PENTSAYINLAKAYEKSGNKSQAISTLEKIINKNNKLALNNLGILYKKEKNYQKAIEIFEKAIINSDIEA KYNLATTLIEINDNTRAKDLLREYTKLKPNNPEALHALGIIEYNENNNDQTLRELIKKFPNKKKNENI KKIIGI f742.nt (SEQ ID NO:323) ATGAATAAAAAACATACAAATTTTTCGGTATTATTGCTTTTAATTTTCTTACTTATCTTA TCATTTGGGGGCTTTGGTTACTATATATATCAAAGCAAATTAAATGACAAAAATCGAGAAATAA TGCTAAACGAAGTTAAAAATAGCGTAATAGATCGAAACTATAAAAAAGCATATTCTGTTGCAA AACTTCTGCAAGACAAATACCCCCAAAATGAAGACATTGCAATGCTTACAAATACACTAGCAGA AATTGCCAACAGTAGTCCTTTTGAATCAAAAGACTTGCAAAGAGATTCTGCTAATCAAATCTTA GACAAGATCAAAGGTCAAGACAATACAAAAACAAATGTAAACGAAAATTTTGATATAGCATTT AATAATAGATACATTAAAGACAGCACAATAACAGAAAACTACTCTGACAGAAACGATGATGTT GGCATTGAAGATGAAGACATATCTGAATTTAAAAAAAGCAAAATCCCAGAAAAAATAAAACCA AATACAAACCCAAAAGAAGAAGACCAAATAATACAATCTCCAAATCCGAAATTAAGTGTTAAT GACCAAAAAAATTTATTTAATTTGGAAAAACTAAAAAAAAATTTAAGTGGAAAATCAAATAGT GAAAATATTTTAAACGATTCTCAAAAAATAGAAAATGATAAGCAAAACACAAATTTATCCAAA GAAAAAAATTCGGAGAATATTTTAAAAACTCCGGACAACAGTAAATATTCAAACAATAACAAT ACTACATCTTTAAAAAAAATTTCTTCAAATTCCCAAAAAGAAAGTGAGCTTTCTCCACCCAGTC AAACAATAATAGGGAAAATTTATAGGCCATATAGCTACTTGATAAAAAAAGAGCTCTATGAAA TATTAGACGATATTAATACCGGAAGAGTCACACTTGGAAAAAACAGATTAAAAGAATTAATTA AAAAAGGTCTAAGCAACAAATTTCAAAAAGTAAATGAATTGATTGAAAATTCAAAAAATAAAG AAGCTTCAAATTTACTATTAACCTTAATAAAAAAAGATATTGAACCAAATCTCATTAATATACC AAAAGATCCTTACAAAAAAGAAATTTTTCAATTAGATAAAGAAGACAAAAAGCCTCAGTACCT AGAGGACCTTAAATCTAAAGTTCATTCAATAAAACCCATTGATCTTGAAAACACAAAATCACGC CAACAAGCCATTAAGGATCTAAACGAATTCTTGAAAAACAATCCCAATGACGCTCAGGCCTCTA AAACTTTAGCTCAAGCTAATAAAATACAACACCTAGAGGACCTTAAATCTAAGGTTCATTCAAT AAAACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACGAATTC TTGAAAAACAATCCCAATGACGCTCAGGCCTCTAAAACTTTAGCTCAAGCTAATAAAATACAAC ACCTAGAGGACCTTAAATCTAAGGTTCATTCAATAAAACCCATTGATCTTGAAAACACAAAATC ACGCCAACAAGCCATTAAGGATCTAAACGAATTCTTAAAAAACAATCCCAATGACGCCCAGGCC TCTAAAACTTTAGCTCAAGCTAATAAAATACAACACCTGGAGGACCTTAAATCTAAGGTTCATT CAATAAAACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACG AATTCTTAAAAACAATCCCAATGACGCCAGGCCTCTAAAACTTTAGCTCAAGCTAATAAAATAC AACACCTGAGGACCTTAAATCTAAGGTTCATTCAATAAAACCCATTGATCTTGAAAACACAAAA TCACGCCAACAAGCCATTAAGGATCTAAACGAATTCTTAAAAACAATCCCAATGACGCCAGGCC TCTAAAACTTTAGCTCAAGCTAATAAAATACAACACCTAGAGGACCTTAAATCTAAGGTTCATT CAATAAAACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACG AATTCTTAAAAAACAATCCCAATGACGCCCAGGCCTCTAAAACTTTAGCTCAAGCTAATAAAAT ACAACACCTGGAGGACCTTAAATCTAAGGTTCATTCAATAAAACCCATTGATCTTGAAAACACA AAATCACGCCAACAAGCCATTAAGGATCTAAACGAATTCTTAAAAACAATCCCAATGACGCCCA GGCCTCTAAAACTTTAGCTCAAGCTTATGAAAACAATGGAGATTTGCTAAAAGCAGAAAATGCA TACGAAAAAATTATCAAACTCACAAATACCCAAGAAGATCACTATAAACTTGGAATCATTAGAT TCAAGCTTAAAAAGTATGAACACTCAATAGAATCATTTGATCAAACAATAAAACTCGACCCAAA ACATAAAAAAGCACTTCATAACAAAGGAATAGCTTTAATGATGCTAAATAAAAACAAAAAAGC AATAGAATCTTTTGAGAAAGCAATACAAATTGATAAAAATTATGGCACCGCCTACTACCAAAAA GGAATAGCAGAAGAAAAAAATGGCGATATGCAACAAGCATTTGCAAGCTTTAAAAATGCCTAC AATCTCGACAAAAACCCCAATTATGCATTAAAAGCAGGAATAGTATCAAATAACTTGGGCAACT TCAAACAAAGTGAAGAGTATTTAAATTTTTTTAATGCCAATGCAAAAAAACCTAACGAAATTGC TATTTACAACCTATCAATAGCAAAATTTGAAAACAATAAACTTGAAGAATCTCTTGAAACAATA AACAAAGCCATAGATTTAAATCCAGAAAAAAGTGAATATTTATATTTAAAAGCATCTATAAATC TTAAAAAAGAAAATTACCAAAATGCTATATCACTTTACAGCTTAGTAATTGAAAAAAACCCTGA AAATACTTCAGCCTATATAAACCTGGCAAAAGCATATGAAAAATCAGGAAATAAAAGTCAAGC AATCTCAACTCTTGAAAAGATAATAAACAAAAATAATAAATTAGCCTTAAACAATCTTGGGATA CTTTACAAAAAAGAAAAAAATTATCAAAAAGCAATTGAAATTTTTGAAAAAGCAATAATCAATT CAGATATTGAAGCAAAATATAATCTTGCAACCACTCTAATTGAAATTAATGATAACACAAGAGC TAAAGACCTTCTAAGAGAATATACAAAATTAAAACCAAACAATCCAGAGGCCTTACATGCACTA GGAATAATAGAATATAATGAAAATAACAATGATCAAACACTAAGAGAACTTATAAAAAAATTT CCAAATTACAAAAAAAATGAAAATATTAAAAAAATAATAGGAATATAA t742.nt (SEQ ID NO:324) AAATTAAATGACAAAAATCGAGAAATAATGCTAAACGAAGTTAAAAATAGCGTAATAG ATCGAAACTATAAAAAAGCATATTCTGTTGCAAAACTTCTGCAAGACAAATACCCCCAAAATGA AGACATTGCAATGCTTACAAATACACTAGCAGAAATTGCCAACAGTAGTCCTTTTGAATCAAAA GACTTGCAAAGAGATTCTGCTAATCAAATCTTAGACAAGATCAAAGGTCAAGACAATACAAAA ACAAATGTAAACGAAAATTTTGATATAGCATTTAATAATAGATACATTAAAGACAGCACAATAA CAGAAAACTACTCTGACAGAAACGATGATGTTGGCATTGAAGATGAAGACATATCTGAATTTA AAAAAAGCAAAATCCCAGAAAAAATAAAACCAAATACAAACCCAAAAGAAGAAGACCAAATA ATACAATCTCCAAATCCGAAATTAAGTGTTAATGACCAAAAAAATTTATTTAATTTGGAAAAAC TAAAAAAAAATTTAAGTGGAAAATCAAATAGTGAAAATATTTTAAACGATTCTCAAAAAATAG AAAATGATAAGCAAAACACAAATTTATCCAAAGAAAAAAATTCGGAGAATATTTTAAAAACTC CGGACAACAGTAAATATTCAAACAATAACAATACTACATCTTTAAAAAAAATTTCTTCAAATTC CCAAAAAGAAAGTGAGCTTTCTCCACCCAGTCAAACAATAATAGGGAAAATTTATAGGCCATAT AGCTACTTGATAAAAAAAGAGCTCTATGAAATATTAGACGATATTAATACCGGAAGAGTCACA CTTGGAAAAAACAGATTAAAAGAATTAATTAAAAAAGGTCTAAGCAACAAATTTCAAAAAGTA AATGAATTGATTGAAAATTCAAAAAATAAAGAAGCTTCAAATTTACTATTAACCTTAATAAAAA AAGATATTGAACCAAATCTCATTAATATACCAAAAGATCCTTACAAAAAAGAAATTTTTCAATT AGATAAAGAAGACAAAAAGCCTCAGTACCTAGAGGACCTTAAATCTAAAGTTCATTCAATAAA ACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACGAATTCTTG AAAAACAATCCCAATGACGCTCAGGCCTCTAAAACTTTAGCTCAAGCTAATAAAATACAACACC TAGAGGACCTTAAATCTAAGGTTCATTCAATAAAACCCATTGATCTTGAAAACACAAAATCACG CCAACAAGCCATTAAGGATCTAAACGAATTCTTGAAAAACAATCCCAATGACGCTCAGGCCTCT AAAACTTTAGCTCAAGCTAATAAAATACAACACCTAGAGGACCTTAAATCTAAGGTTCATTCAA TAAAACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACGAATT CTTAAAAAACAATCCCAATGACGCCCAGGCCTCTAAAACTTTAGCTCAAGCTAATAAAATACAA CACCTGGAGGACCTTAAATCTAAGGTTCATTCAATAAAACCCATTGATCTTGAAAACACAAAAT CACGCCAACAAGCCATTAAGGATCTAAACGAATTCTTAAAAACAATCCCAATGACGCCAGGCCT CTAAAACTTTAGCTCAAGCTAATAAAATACAACACCTGAGGACCTTAAATCTAAGGTTCATTCA ATAAAACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACGAAT TCTTAAAAACAATCCCAATGACGCCAGGCCTCTAAAACTTTAGCTCAAGCTAATAAAATACAAC ACCTAGAGGACCTTAAATCTAAGGTTCATTCAATAAAACCCATTGATCTTGAAAACACAAAATC ACGCCAACAAGCCATTAAGGATCTAAACGAATTCTTAAAAAACAATCCCAATGACGCCCAGGCC TCTAAAACTTTAGCTCAAGCTAATAAAATACAACACCTGGAGGACCTTAAATCTAAGGTTCATT CAATAAAACCCATTGATCTTGAAAACACAAAATCACGCCAACAAGCCATTAAGGATCTAAACG AATTCTTAAAAACAATCCCAATGACGCCCAGGCCTCTAAAACTTTAGCTCAAGCTTATGAAAAC AATGGAGATTTGCTAAAAGCAGAAAATGCATACGAAAAAATTATCAAACTCACAAATACCCAA GAAGATCACTATAAACTTGGAATCATTAGATTCAAGCTTAAAAAGTATGAACACTCAATAGAAT CATTTGATCAAACAATAAAACTCGACCCAAAACATAAAAAAGCACTTCATAACAAAGGAATAG CTTTAATGATGCTAAATAAAAACAAAAAAGCAATAGAATCTTTTGAGAAAGCAATACAAATTG ATAAAAATTATGGCACCGCCTACTACCAAAAAGGAATAGCAGAAGAAAAAAATGGCGATATGC AACAAGCATTTGCAAGCTTTAAAAATGCCTACAATCTCGACAAAAACCCCAATTATGCATTAAA AGCAGGAATAGTATCAAATAACTTGGGCAACTTCAAACAAAGTGAAGAGTATTTAAATTTTTTT AATGCCAATGCAAAAAAACCTAACGAAATTGCTATTTACAACCTATCAATAGCAAAATTTGAAA ACAATAAACTTGAAGAATCTCTTGAAACAATAAACAAAGCCATAGATTTAAATCCAGAAAAAA GTGAATATTTATATTTAAAAGCATCTATAAATCTTAAAAAAGAAAATTACCAAAATGCTATATC ACTTTACAGCTTAGTAATTGAAAAAAACCCTGAAAATACTTCAGCCTATATAAACCTGGCAAAA GCATATGAAAAATCAGGAAATAAAAGTCAAGCAATCTCAACTCTTGAAAAGATAATAAACAAA AATAATAAATTAGCCTTAAACAATCTTGGGATACTTTACAAAAAAGAAAAAAATTATCAAAAA GCAATTGAAATTTTTGAAAAAGCAATAATCAATTCAGATATTGAAGCAAAATATAATCTTGCAA CCACTCTAATTGAAATTAATGATAACACAAGAGCTAAAGACCTTCTAAGAGAATATACAAAATT AAAACCAAACAATCCAGAGGCCTTACATGCACTAGGAATAATAGAATATAATGAAAATAACAA TGATCAAACACTAAGAGAACTATAAAAAAATTTCCAAATTACAAAAAAAATGAAAATATTAAA AAAATAATAGGAATATAA f743.aa (SEQ ID NO:325) MRIYLFLNKNYKIFILFLILILNSKLAYSQRLIRIGKEEMKNKNYIQAIETLSDAIKKYPKVQLGYYFLS IAYRENNQLTEAEGALLDGIAVGGEIDYILYYELGNIMFNRGEGYYPLAIKYYSNSIKSRPNYDSALL NRANAYVQQGKITSKEKEYQKAWDSYTMAIHDYSQFITLRSKTEKKDSILLIISYLRNEKINLEQLDK SLKGRTEHIVYAKEDKNQILKDSFKDNLETNSLIELEKLNWQEELYIDE t743.aa (SEQ ID NO:326) YSQRLIRIGKEEMKNKNYIQAIETLSDAIKKYPKVQLGYYFLSIAYRENNQLTEAEGALLDGIAVGGE IDYILYYELGNIMFNRGEGYYPLAIKYYSNSIKSRPNYDSALLNRANAYVQQGKITSKEKEYQKAWD SYTMAIHDYSQFITLRSKTEKKDSILLIISYLRNEKINLEQLDKSLKGRTEHIVYAKEDKNQILKDSFK DNLETNSLIELEKLNWQEELYIDE f743.nt (SEQ ID NO:327) ATGAGGATTTATTTATTTTTAAATAAAAATTACAAGATTTTTATTTTATTTTTAATTTTAATATT AAATTCAAAATTGGCATATTCTCAAAGGCTAATTAGAATTGGCAAAGAAGAGATGAAAAACAA AAATTACATTCAAGCAATCGAAACACTAAGTGATGCTATTAAAAAATATCCAAAAGTACAACTC GGCTATTA TTTATCAATAGCATACAGAGAAAATAATCAACTAACAGAAGCAGAAGGAGCA TTGCTCGATGGAATTGCAGTAGGGGGTGAAATCGACTACATACTATATTATGAATTAGGCAACA TAATGTTTAACAGAGGGGAAGGTTACTATCCTTTAGCAATAAAATATTATTCTAATTCTATTAA AAGTAGACCTAATTATGACAGTGCGCTACTAAACAGAGCTAATGCCTATGTTCAACAGGGCAAA ATAACTTCTAAAGAAAAAGAATACCAAAAAGCTTGGGACTCTTATACTATGGCTATCCACGACT ACTCTCAATTTATTACCCTTAGATCAAAAACAGAAAAAAAAGACAGCATTTTGCTTATAATAAG CTATTTAAGAAATGAAAAAATTAATCTTGAACAACTTGACAAAAGTTTGAAGGGGCGAACCGA GCATATTGTATACGCAAAAGAAGATAAAAATCAAATACTTAAAGATAGTTTTAAAGACAACCT AGAAACAAATTCTAATTGAGCTAGAAAAACTTAATTGGCAAGAGGAGTTATACATAGATGA ATAA t743.nt (SEQ ID NO:328) TATTCTCAAAGGCTAATTAGAATTGGCAAAGAAGAGATGAAAAACAAAATTACATTC AAGCAATCGAAACACTAAGTGATGCTATTAAAAAATATCCAAAAGTACAACTCGGCTATTACTT TTTATCAATAGCATACAGAGAAAATAATCAACTAACAGAAGCAGAAGGAGCATTGCTCGATGG AATTGCAGTAGGGGGTGAAATCGACTACATACTATATTATGAATTAGGCAACATAATGTTTAAC AGAGGGGAAGGTTACTATCCTTTAGCAATAAAATATTATTCTAATTCTATTAAAAGTAGACCTA ATTATGACAGTGCGCTACTAAACAGAGCTAATGCCTATGTTCAACAGGGCAAAATAACTTCTAA AGAAAAAGAATACCAAAAAGCTTGGGACTCTTATACTATGGCTATCCACGACTACTCTCAATTT ATTACCCTTAGATCAAAAACAGAAAAAAAAGACAGCATTTTGCTTATAATAAGCTATTTAAGAA ATGAAAAAATTAATCTTGAACAACTTGACAAAAGTTTGAAGGGGCGAACCGAGCATATTGTAT ACGCAAAAGAAGATAAAAATCAAATACTTAAAGATAGTTTTAAAGACAACCTAGAAACAAATT CTTTAATTGAGCTAGAAAAACTTAATTGGCAAGAGGAGTTATACATAGATGAATAA f748.aa (SEQ ID NO:329) MKFIINLLLSTIKIITFTVIVCLTILSIFQPIYILKENEISITTRLGKIQRTENLAGLKYKIPLIENVQIFPKII LRWDGEPQRIPTGGEEKQLIWIDTTARWKIADINKFYTTIKTMSRAYVRIDAAIEPAVRGVIAKYPLL EIIRSSNDPIQRLSNGILTPQETKINGIYKITKGRKIIEKEIIRIANNNTKDIGIEIVDVLIRKVTYDPSLIES VNNRMISERQQIAEEQRSIGLAEKTEILGSIEKEKLKILSEAKATAAKIKAEGDREAAKIYSNAYGKNI EFYKFWQALESYKAVLKDKRKIFSTDMDFFQYLHKRN t748.aa (SEQ ID NO:330) IFQPIYILKENEISITTRLGKIQRTENLAGLKYKIPLIENVQIFPKIILRWDGEPQRIPTGGEEKQ LIWIDTTARWKIADINKFYTTIKTMSRAYVRIDAAIEPAVRGVIAKYPLLEIIRSSNDPIQRLSNGILTP QETKINGIYKITKGRKIIEKEIIRIANNNTKDIGIEIVDVLIRKVTYDPSLIESVNNRMISERQQIAEEQRS IGLAEKTEILGSIEKEKLKILSEAKATAAKIKAEGDREAAKIYSNAYGKNIEFYKFWQALESYKAVLK DKRKIFSTDMDFFQYLHKRN f748.nt (SEQ ID NO:331) ATGAAATTTATAATAAATCTTTTATTATCTACTATAAAGATTATAACCTTTACAGTAAT AGTTTGCTTGACTATTTTGTCTATTTTCCAGCCAATTTATATTTTGAAAGAAAATGAAATTTCAA TAACCACTCGACTTGGAAAAATTCAAAGAACTGAAAATTTAGCTGGACTTAAATATAAAATACC ATTAATTGAAAATGTGCAAATATTTCCCAAAATCATTCTTAGATGGGATGGAGAACCTCAAAGA ATCCCAACAGGAGGGGAAGAAAAGCAATTAATATGGATTGATACAACTGCTAGATGGAAAATT GCAGACATAAATAAATTTTACACAACAATAAAAACAATGAGTAGAGCTTACGTTAGAATTGAT GCAGCAATTGAACCTGCTGTTAGGGGGGTTATTGCAAAATACCCTTTGCTTGAAATTATAAGAA GCTCAAACGATCCTATTCAACGTTTGTCTAATGGAATACTCACCCCACAAGAAACAAAAATTAA CGGTATTTATAAAATAACAAAAGGACGAAAGATAATCGAAAAAGAAATAATTCGTATAGCAAA CAACAATACCAAAGATATTGGAATTGAAATTGTAGACGTACTAATAAGAAAAGTTACTTATGAC CCAAGCCTTATTGAATCTGTAAACAACAGAATGATCTCAGAAAGACAACAAATCGCAGAAGAA CAAAGAAGCATAGGATTAGCTGAAAAAACAGAAATTCTTGGAAGCATAGAAAAAGAAAAACTG AAAATATTAAGTGAAGCAAAAGCCACTGCTGCAAAAATAAAAGCCGAAGGGGATAGAGAAGCC GCAAAAATTATTCAAATGCATATGGCAAAAATATTGAATTTTACAAATTCTGGCAGGCATTAG AAAGCTATAAAGCAGTATTAAAAGATAAAAGAAAAATTTTCTCAACAGACATGGATTTCTTTCA ATATCTTCACAAAAGAAATTGA t748.nt (SEQ ID NO:332) ATTTTCCAGCCAATTTATATTTGAAAGAAAATGAAATTTCAATAACCACTCGACTTGG AAAAATTCAAAGAACTGAAAATTTAGCTGGACTTAAATATAAAATACCATTAATTGAAAATGTG CAAATATTTCCCAAAATCATTCTTAGATGGGATGGAGAACCTCAAAGAATCCCAACAGGAGGG GAAGAAAAGCAATTAATATGGATTGATACAACTGCTAGATGGAAAATTGCAGACATAAATAAA TTTACACAACAATAAAAACAATGAGTAGAGCTTACGTTAGAATTGATGCAGCAATTGAACCTG CTGTTAGGGGGGTTATTGCAAAATACCCTTTGCTTGAAATTATAAGAAGCTCAAACGATCCTAT TCAACGTTTGTCTAATGGAATACTCACCCCACAAGAAACAAAAATTAACGGTATTTATAAAATA ACAAAAGGACGAAAGATAATCGAAAAAGAAATAATTCGTATAGCAAACAACAATACCAAAGAT ATTGGAATTGAAATTGTAGACGTACTAATAAGAAAAGTTACTTATGACCCAAGCCTTATTGAAT CTGTAAACAACAGAATGATCTCAGAAAGACAACAAATCGCAGAAGAACAAAGAAGCATAGGAT TAGCTGAAAAAACAGAAATTCTTGGAAGCATAGAAAAAGAAAAACTGAAAATATTAAGTGAAG CAAAAGCCACTGCTGCAAAAATAAAAGCCGAAGGGGATAGAGAAGCCGCAAAAATTTATTCAA ATGCATATGGCAAAAATATTGAATTTTACAAATTCTGGCAGGCATTAGAAAGCTATAAAGCAGT ATTAAAAGATAAAAGAAAAATTTTCTCAACAGACATGGATTTCTTTCAATATCTTCACAAAAGA AATTGA f764.aa (SEQ ID NO:333) MSGPKKLAIIALLVISIQGCKESSIIEKQFNYAIIFSDATEYFFEIQTTPFIKNEILFINDKNLEIIK DKLKTTKKILLTHKSNNEILNNEILKEKIFYLSKIKFSLKKSIDFLLNEKSIDLQKTLLFRDKSLNNEDL EYLEKKGKEKNVNITLINEKNISYIQTFITSQIKTIILFSLRDNNIILKKILNSPFSKNIKFVLIGNTRKDL KIIKLKYIITLKEPDLIKIAKDVEKDFQYEFNIYKQ f764.aa (SEQ ID NO:334) EKQFNYAIIFSDATEYFFEIQTTPFIKNEILFINDKNLEIIKDKLKTTKKILLTHKSNNEILNNEI LKEKIFYLSKIKFSLKKSIDFLLNEKSIDLQKTLLFRDKSLNNEDLEYLEKKGKEKNVNITLINEKNISY IQTFITSQIKTIILFSLRDNNIILKKILNSPFSKNIKFVLIGNTRKDLKIIKLKYIITLKEPDLIKIAKDVEKD FQYEFNIYKQ f764.nt (SEQ ID NO:335) ATGTCTGGCCCTAAAAAACTTGCTATAATAGCGCTCTTAGTAATTTCAATACAAGGATG CAAAGAATCTTCTATTATTGAAAAACAATTTAATTATGCAATAATTTTTCAGATGCAACTGAA TATTTTTTTGAAATTCAAACAACTCCATTCATAAAAAACGAAATACTATTTATAAATGACAAAA ATTTAGAAATTATAAAAGACAAGCTTAAAACAACAAAAAAAATACTATTAACTCATAAATCAA ATAATGAAATTCTAAATAACGAAATTCTAAAAGAGAAAATTTTTTATCTATCAAAAATAAAATT TTCTCTAAAAAAATCTATTGACTTTCTGCTTAACGAAAAATCAATAGATTTGCAAAAAACATTA CTATTTAGAGACAAATCTCTAAATAACGAAGACCTTGAATACTTGGAAAAAAAAGGCAAAGAA AAAAATGTCAATATTACTCTAATAAACGAAAAAAACATATCCTATATTCAAACATTCATTACTT CTCAAATAAAAACAATAATATTATTCTCTTTAAGAGATAATAATATTATTTTAAAAAGATACT AAATTCGCCTTTTTCTAAAAATATAAAATTTGTATTAATTGGCAATACAAGAAAAGACTTAAAA ATTATTAAGCTAAAATATATAATCACCCTTAAAGAGCCTGATTTGATAAAAATAGCAAAAGATG TTGAAAAAGATTTTCAATATGAATTTAACATTTATAAACAATAA t764.nt (SEQ ID NO:336) GAAAAACAATTTAATTATGCAATAATTTTTTCAGATGCAACTGAATATTTTTTTGAAAT TCAAACAACTCCATTCATAAAAAACGAAATACTATTTATAAATGACAAAAATTTAGAAATTATA AAAGACAAGCTTAAAACAACAAAAAAAATACTATTAACTCATAAATCAAATAATGAAATTCTA AATAACGAAATTCTAAAAGAGAAAATTTTTTATCTATCAAAAATAAAATTTTCTCTAAAAAAAT CTATTGACTTTCTGCTTAACGAAAAATCAATAGATTTGCAAAAAACATTACTATTTAGAGACAA ATCTCTAAATAACGAAGACCTTGAATACTTGGAAAAAAAAGGCAAAGAAAAAAATGTCAATAT TACTCTAATAAACGAAAAAAACATATCCTATATTCAAACATTCATTACTTCTCAAATAAAAACA ATAATATTATTCTCTTTAAGAGATAATAATATTATTTTAAAAAAGATACTAAATTCGCCTTTTTC TAAAAATATAAAATTTGTATTAATTGGCAATACAAGAAAAGACTTAAAAATTATTAAGCTAAAA TATATAATCACCCTTAAAGAGCCTGATTTGATAAAAATAGCAAAAGATGTTGAAAAAGATTTTC AATATGAATTTAACATTTATAAACAATAA f770.aa (SEQ ID NO:337) MINFSKSFFYPLPIGKIFVLSGDMGSGKTSFLKGLALNLGISYFTSPTYNIVNVYDFINFKFYH IDLYRVSSLEEFELVGGLEILMDLDSIIAIEWPQIALSIVPKDRLFSLTFKIVGSGRVVELNG t770.aa (SEQ ID NO:338) KTSFLKGLALNLGISYFTSPTYNIVNVYDFINFKFYHIDLYRVSSLEEFELVGGLEILMDLDSI IAIEWPQIALSIVPKDRLFSLTFKIVGSGRVVELNG f770.nt (SEQ ID NO:339) ATGATAAATTTTTCCAAATCTTTTTTTTATCCTTTGCCAATTGGTAAAATATTTGTTTTA AGTGGTGACATGGGATCTGGAAAAACTAGTTTTTTAAAGGGACTTGCCCTTAACCTTGGAATTT CTTATTTTACAAGTCCAACTTATAACATTGTTAATGTTTATGATTTTATAAATTTTAAATTTTATC ATATTGATTTATATCGGGTGTCTTCTTTGGAAGAATTTGAGCTTGTTGGGGGATTGGAAATACT TATGGATCTTGACTCGATTATTGCTATTGAATGGCCACAAATTGCTTTGAGCATTGTTCCAAAA GATAGATTATTTTCTTTAACTTTTAAAATAGTAGGTTCAGGCAGGGTTGTAGAACTTAATGGTT AA t770.nt (SEQ ID NO:340) AAAACTAGTTTTTTAAAGGGACTTGCCCTTAACCTTGGAATTTCTTATTTTACAAGTCCAACTTA TAACATTGTTAATGTTTATGATTTTATAAATTTTAAATTTTATCATATTGATTTATATCGGGTGT CTTCTTTGGAAGAATTTGAGCTTGTTGGGGGATTGGAAATACTTATGGATCTTGACTCGATTAT TGCTATTGAATGGCCACAAATTGCTTTGAGCATTGTTCCAAAAGATAGATTATTTTCTTTAACTT TTAAAATAGTAGGTTCAGGCAGGGTTGTAGAACTTAATGGTTAA f790.aa (SEQ ID NO:341) MNTKATTPLLLLFLIQSLAFSSEIFEFKYIKGSKFRLEGTDNQKIYFNGHYNSSSNTNIQISSEI KDIKENFASIKAFFRILKRENINEPYLLNEEFEEIFSVNKQGEYTIGANQKRPSVRGIPRFPKTPIKTNEK WSYLAEEYIEASKIDKSIKDFVVKFNVNYEYKGKEEHNGKHYHIILSNYESQYNVKNISSFYQKVDQK IYFDNEIGNTYKYSDKYIFEINQNNNQHFKMIGNSLGRIVSIELPNDNLIETEVENYIREKKIKAIEVEK NNKGINLSFDIEFYPNSFQILQKEYKKIDLIAKLLEKFKKNNILIEGHTEQFGLEEEMHELSEKRARAI GNYLIKMKVKDKDQILFKGWGSQKPKYPKSSPLKAKNRRVEITILNN t790.aa (SEQ ID NO:342) SEIFEFKYIKGSKFRLEGTDNQKIYFNGHYNSSSNTNIQISSEIKDIKENFASIKAFFRILKRENI NEPYLLNEEFEEIFSVNKQGEYTIGANQKRPSVRGIPRFPKTPIKINEKWSYLAEEYIEASKIDKSIKDF VVKFNVNYEYKGKEEHNGKHYHIILSNYESQYNVKNISFYQKVDQKIYFDNEIGNTYKYSDKYIFEI NQNNNQHFKMIGNSLGRIVSIELPNDNLIETEVENYIREKKIKAIEVEKNNKGINLSFDIEFYPNSFQIL QKEYKKIDITAKLLEKFKKNNILIEGHTEQFGLEEEMHELSEKRARAIGNYLIKMKVKDKDQILFKG WGSQKPKYPKSSPLKAKNRRVEITILNN f790.nt (SEQ ID NO:343) ATGAATACCAAGGCGACTACACCATTGTTGTTATTATTTTTAATTCAAAGCTTAGCTTT TTCTTCTGAAATCTTTGAATTTAAATACATTAAAGGTTCAAAGTTTAGATTAGAAGGCACAGAT AATCAAAAAATATATTTCAATGGCCATTATAATTCAAGCTCTAATACCAATATTCAAATTTCAA GTGAAATAAAAGACATAAAAGAAAACTTTGCAAGCATTAAAGCTTTTTTTAGAATCTTAAAAAG AGAAAATATTAATGAACCTTACCTATTAAATGAAGAGTTTGAAGAAATCTTCAGCGTAAATAAG CAAGGAGAATATACAATAGGAGCAAATCAAAAAAGACCTTCTGTTAGAGGTATTCCAAGATTC CCAAAAACACCAATCAAAATAAATGAAAAATGGTCATATCTTGCAGAAGAATATATAGAAGCG TCAAAAATAGACAAAAGTATAAAAGATTTCGTTGTAAAATTTAATGTTAACTACGAATATAAAG GCAAAGAAGAGCACAATGGCAAGCATTACCACATAATTCTTTCGAATTATGAATCACAATACAA TGTAAAAAACATCTCTTTCTATCAAAAAGTAGACCAAAAAATTTATTTTGATAATGAAATTGGC AATACATATAAATACAGCGATAAATATATATTTGAAATAAATCAGAACAACAACCAACATTTTA AAATGATTGGAAACTCTCTTGGCAGAATAGTTTCAATTGAGCTTCCAAATGATAATCTTATTGA AACTGAGGTTGAAAATTACATCCGAGAAAAAAAAATAAAAGCTATTGAAGTTGAAAAAAACAA TAAAGGTATTAATTTAAGCTTTGACATTGAATTTTATCCTAACTCATTTCAAATACTACAAAAAG AATATAAAAAAATTGACCTTATAGCTAAACTTCTTGAAAAATTTAAAAAAAATAACATACTAAT AGAAGGACATACTGAGCAATTTGGATTGGAAGAAGAGATGCACGAGCTATCTGAAAAAAGAGC TCGTGCAATTGGAAATTATTTAATAAAAATGAAAGTAAAAGACAAAGACCAAATACTATTTAA AGGATGGGGATCTCAAAAACCAAAATATCCTAAGTCCTCCCCATTAAAGGCTAAAAATAGGCG AGTAGAAATTACAATATTAAATAACTAA t790.nt (SEQ ID NO:344) TCTGAAATCTTTGAATTTAAATACATTAAAGGTTCAAAGTTTAGATTAGAAGGCACAGA TAATCAAAAAATATATTTCAATGGCCATTATAATTCAAGCTCTAATACCAATATTCAAATTTCA AGTGAAATAAAAGACATAAAAGAAAACTTTGCAAGCATTAAAGCTTTTTTTAGAATCTTAAAAA GAGAAAATATTAATGAACCTTACCTATTAAATGAAGAGTTTGAAGAAATCTTCAGCGTAAATAA GCAAGGAGAATATACAATAGGAGCAAATCAAAAAAGACCTTCTGTTAGAGGTATTCCAAGATT CCCAAAAACACCAATCAAAATAAATGAAAAATGGTCATATCTTGCAGAAGAATATATAGAAGC GTCAAAAATAGACAAAAGTATAAAAGATTTCGTTGTAAAATTTAATGTTAACTACGAATATAAA GGCAAAGAAGAGCACAATGGCAAGCATTACCACATAATTCTTTCGAATTATGAATCACAATACA ATGTAAAAAACATCTCTTTCTATCAAAAAGTAGACCAAAAAATTTATTTTGATAATGAAATTGG CAATACATATAAATACAGCGATAAATATATATTTGAAATAAATCAGAACAACAACCAACATTTT AAAATGATTGGAAACTCTCTTGGCAGAATAGTTTCAATTGAGCTTCCAAATGATAATCTTATTG AAACTGAGGTTGAAAATTACATCCGAGAAAAAAAAATAAAAGCTATTGAAGTTGAAAAAAACA ATAAAGGTATTAATTTAAGCTTTGACATTGAATTTTATCCTAACTCATTTCAAATACTACAAAAA GAATATAAAAAAATTGACCTTATAGCTAAACTTCTTGAAAAATTTAAAAAAAATAACATACTAA TAGAAGGACATACTGAGCAATTTGGATTGGAAGAAGAGATGCACGAGCTATCTGAAAAAAGAG CTCGTGCAATTGGAAATTATTTAATAAAAATGAAAGTAAAAGACAAAGACCAAATACTATTTAA AGGATGGGGATCTCAAAAACCAAAATATCCTAAGTCCTCCCCATTAAAGGCTAAAAATAGGCG AGTAGAAATTACAATATTAAATAACTAA f792.aa (SEQ ID NO:345) MKIFIYWVVIFFFSVFKVFSIYSLTDEEFFKKYSLFFVHKGFLSKNVNGKITKVQVNGINSRWVYPFY KLVPSRITSIYEDVYSSSSFLTTSNNLYVSYDYSKNFRKLVGIDKFNSGAYITSSAFSQGDYKRIAIGT AIHGIYLSVNGAISFKNLNRLIPQIYLGAGYYDIISAIEFSKEETNNLYFSSGVYGDIFLISQKSGFIKKIS FPFKKQIIRILDLSSKNVEKILVRTYDNHFYSYINGQWVFIGKLSLQDQDFFEKSQRMQLAKNKGSIY LTAYTLRNKKAVDERFKFIKDSGMNAVVIDFKDDNGNLTYSSKLSLPNKLRSVKNFIDVPYILKKAK ELGIYVIARCVVFKDSKLYYYDNFKHALWNKKTNKPWAHLIKKVDSSGLVKYVQVEHWVDIFSPA TWEYNISIAKEIQSFGVDEIQFDYIRFPSDGPVSLAISRMNKYEMQPVDALESFLIMAREQLYVPISVD IYGYNGWFPTNSIGQNISMLSDYVDVISPMFYPSHYTDDFLPSNFYYTKRAYRIYKEGSDRALAFSL DGVVIRPYVQAFLLGKERLVDDEIYLEYLKFQLKGIKESFGSGFSLWNASNVYYMIKGSLKEYLDSF t792.aa (SEQ ID NO:346) IYSLTDEEFFKKYSLFFVHKGFLSKNVNGKITKVQVNGINSRWVYPFYKLVPSRITSIYEDV YSSSSFLTTSNNLYVSYDYSKNFRKLVGIDKFNSGAYITSSAFSQGDYKRIAIGTAIHGIYLSVNGAISF KNLNRLIPQIYLGAGYYDIISAIEFSKEETNNLYFSSGVYGDIFLISQKSGFIKKISFPFKKQIIRILDLSS KNVEKILVRTYDNHFYSYINGQWVFIGKLSLQDQDFFEKSQRMQLAKNKGSIYLTAYTLRNKKAVD ERFKFIKDSGMNAVVIDFKDDNGNLTYSSKLSLPNKLRSVKNFIDVPYILKKAKELGIYVIARCVVFK DSKLYYYDNFKHALWNKKTNKPWAHLIKKVDSSGLVKYVQVEHWVDIFSPATWEYNISIAKEIQSF GVDEIQFDYIRFPSDGPVSLAISRMNKYEMQPVDALESFLIMAREQLYVPISVDIYGYNGWFPTNSIG QNISMLSDYVDVISPMFYPSHYTDDFLPSNFYYTKRAYRIYKEGSDRALAFSLDGVVIRPYVQAFLL GKEFLVDDEIYLEYLKFQLKGIKESFGSGFSLWNASNVYYMIKGSLKEYLDSF f792.nt (SEQ ID NO:347) ATGAAAATTTTTATCTATTGGGTAGTTATTTTCTTCTTTTCTGTTTTCAAGGTTTTTAGT ATATATTCATTAACCGATGAAGAATTTTTTAAAAAATATAGTTTATTTTTTGTTCATAAAGGATT TTTAAGTAAAAATGTTAATGGGAAAATAACCAAAGTTCAAGTCAATGGGATAAATTCTAGGTG GGTTTACCCTTTTTATAAGCTTGTTCCTAGTCGAATTACTTCTATTTATGAGGATGTTTATTCTTC AAGTTCATTTTTGACTACAAGTAACAATCTTTATGTTTCTTATGATTATTCAAAAAATTTTAGAA AATTAGTAGGAATTGATAAATTTAATAGCGGTGCATATATTACATCTAGTGCCTTTTCTCAAGG AGATTACAAGCGTATTGCTATTGGAACTGCGATTCATGGTATTTATCTTAGTGTTAATGGAGCT ATTAGTTTTAAAAATTTAAATCGTTTGATTCCGCAGATTTATTTAGGTGCAGGATATTACGATAT TATTAGTGCTATTGAATTTTCAAAAGAAGAGACAAATAATTTATATTTTTCCTCTGGAGTTTATG GAGATATTTTTTTAATTAGTCAGAAAAGTGGATTTATTAAAAAAATATCTTTTCCTTTCAAAAA GCAAATAATACGTATTTTAGACTTATCTAGTAAGAATGTAGAAAAAATTTTAGTCAGAACATAT GACAATCATTTTTATTCTTATATTAATGGGCAATGGGTATTTATTGGAAAATTATCTTTGCAGGA TCAGGATTTTTTTGAAAAATCACAAAGGATGCAGCTTGCTAAAAATAAAGGGTCTATTTATTTTA ACAGCATATACATTGCGTAATAAGAAGGCAGTTGATGAAAGATTTAAATTTATTAAAGATTCAG GTATGAATGCTGTTGTAATTGATTTTAAAGATGATAATGGTAATTTGACTTATTCTAGCAAGCTT TCTTTGCCCAATAAGTTGAGATCTGTTAAAAACTTTATTGATGTTCCTTATATTCTTAAAAAAGC AAAAGAGCTTGGAATTTATGTTATTGCTAGATGTGTTGTATTTAAAGATTCAAAATTGTATTATT ATGATAATTTTAAACACGCCCTTTGGAATAAAAAAACCAATAAACCTTGGGCTCATTTGATTAA AAAAGTTGATTCTAGTGGTCTTGTGAAATATGTACAAGTAGAGCATTGGGTAGATATTTTTTCT CCTGCTACTTGGGAATATAATATTTCTATCGCAAAAGAAATTCAATCTTTTGGAGTTGACGAGA TACAATTTGATTATATTAGATTTCCATCAGATGGGCCTGTGTCTCTTGCAATCTCAAGAATGAAT AAGTATGAGATGCAACCCGTTGATGCACTTGAATCTTTTTTGATTATGGCAAGAGAACAGCTTT ATGTTCCTATTTCTGTTGATATTTATGGGTACAATGGCTGGTTTCCTACTAATAGTATTGGGCAA AATATTTCAATGTTATCAGATTATGTTGACGTCATATCTCCTATGTTTTATCCTTCGCATTATAC TGATGATTTTTTGCCAAGCAATTTTTATTACACAAAAAGAGCTTATAGGATTTATAAAGAGGGG AGTGATAGAGCACTTGCTTTTTCTTTAGATGGGGTTGTTATTAGGCCTTATGTTCAAGCTTTTTT ATTAGGAAAAGAAAGATTGGTGGATGACGAGATTTATTTGGAGTATTTAAAGTTTCAGCTTAAA GGAATTAAAGAGTCATTTGGTAGTGGCTTTAGCCTTTGGAATGCATCTAATGTTTATTATATGA TTAAAGGTAGTTTAAAAGAATATTTAGATTCTTTTTTA t792.nt (SEQ ID NO:348) ATATATTCATTAACCGATGAAGAATTTTTTAAAAAATATAGTTTATTTTTTGTTCATAA AGGATTTTTAAGTAAAAATGTTAATGGGAAAATAACCAAAGTTCAAGTCAATGGGATAAATTCT AGGTGGGTTTACCCTTTTTATAAGCTTGTTCCTAGTCGAATTACTTCTATTTATGAGGATGTTTA TTCTTCAAGTTCATTTTTGACTACAAGTAACAATCTTTATGTTTCTTATGATTATTCAAAAAATT TTAGAAAATTAGTAGGAATTGATAAATTTAATAGCGGTGCATATATTACATCTAGTGCCTTTTC TCAAGGAGATTACAAGCGTATTGCTATTGGAACTGCGATTCATGGTATTTATCTTAGTGTTAAT GGAGCTATTAGTTTTAAAAATTTAAATCGTTTGATTCCGCAGATTTATTTAGGTGCAGGATATT ACGATATTATTAGTGCTATTGAATTTTCAAAAGAAGAGACAAATAATTTATATTTTTCCTCTGG AGTTTATGGAGATATTTTTTTAATTAGTCAGAAAAGTGGATTTATTAAAAAAATATCTTTTCCTT TCAAAAAGCAAATAATACGTATTTTAGACTTATCTAGTAAGAATGTAGAAAAAATTTTAGTCAG AACATATGACAATCATTTTTATTCTTATATTAATGGGCAATGGGTATTTATTGGAAAATTATCTT TGCAGGATCAGGATTTTTTTGAAAAATCACAAAGGATGCAGCTTGCTAAAAATAAAGGGTCTAT TTATTTAACAGCATATACATTGCGTAATAAGAAGGCAGTTGATGAAAGATTTAAATTTATTAAA GATTCAGGTATGAATGCTGTTGTAATTGATTTTAAAGATGATAATGGTAATTTGACTTATTCTA GCAAGCTTTCTTTGCCCAATAAGTTGAGATCTGTTAAAAACTTTATTGATGTTCCTTATATTCTT AAAAAAGCAAAAGAGCTTGGAATTTATGTTATTGCTAGATGTGTTGTATTTAAAGATTCAAAAT TGTATTATTATGATAATTTTAAACACGCCCTTTGGAATAAAAAAACCAATAAACCTTGGGCTCA TTTGATTAAAAAAGTTGATTCTAGTGGTCTTGTGAAATATGTACAAGTAGAGCATTGGGTAGAT ATTTTTTCTCCTGCTACTTGGGAATATAATATTTCTATCGCAAAAGAAATTCAATCTTTTGGAGT TGACGAGATACAATTTGATTATATTAGATTTCCATCAGATGGGCCTGTGTCTCTTGCAATCTCAA GAATGAATAAGTATGAGATGCAACCCGTTGATGCACTTGAATCTTTTTTGATTATGGCAAGAGA ACAGCTTTATGTTCCTATTTCTGTTGATATTTATGGGTACAATGGCTGGTTTCCTACTAATAGTA TTGGGCAAAATATTTCAATGTTATCAGATTATGTTGACGTCATATCTCCTATGTTTTATCCTTCG CATTATACTGATGATTTTTTGCCAAGCAATTTTTATTACACAAAAAGAGCTTATAGGATTTATAA AGAGGGGAGTGATAGAGCACTTGCTTTTTCTTTAGATGGGGTTGTTATTAGGCCTTATGTTCAA GCTTTTTTATTAGGAAAAGAAAGATTGGTGGATGACGAGATTTATTTGGAGTATTTAAAGTTTC AGCTTAAAGGAATTAAAGAGTCATTTGGTAGTGGCTTTAGCCTTTGGAATGCATCTAATGTTTA TTATATGATTAAAGGTAGTTTAAAAGAATATTTAGATTCTTTTTAA f797.aa (SEQ ID NO:349) MSIKKFILTLIILSLAKNSFSENEINIFENENYIVKENIKTEIKKLKQSFLLASVDVAISQPYIEL ADLNGEPIKELEGISYSFINVFSKIGSSAIISFDLSNEASKKYKIIKLEFLSPDKGNFINQLSSLTSGKQQS KKELAKDAYSFGTLRTESLSKTIAEYYKDNNWYYILAAITVENNINKETEKYEIRINPKIYNDFQKKL RLHFKSNQIKKFPIPIIE t797.aa (SEQ ID NO:350) KNSFSENEINIFENENYIVKENIKTEIKKLKQSFLLASVDVAISQPYIELADLNGEPIKELEGIS YSFINVFSKIGSSAIISFDLSNEASKKYKIIKLEFLSPDKGNFINQLSSLTSGKQQSKKELAKDAYSFGT LRTESLSKTIAEYYKDNNWYYILAAITVENNINKETEKYEIRINPKIYNDFQKKLRLHFKSNQIKKFPI PIIE f797.nt (SEQ ID NO:351) ATGAGCATTAAAAAATTTATTTTAACCTTGATAATTCTTTCTCTAGCTAAAAATAGCTTT TCTGAAAACGAAATTAATATCTTCGAAAACGAAAATTATATTGTAAAAGAAAATATAAAAACA GAAATTAAAAAACTAAAACAAAGTTTTTTACTTGCATCTGTTGATGTCGCCATTAGCCAACCCT ACATAGAATTGGCAGATTTAAATGGAGAACCGATAAAAGAACTTGAAGGGATTAGTTATTCAT TTATAAATGTATTTTCAAAAATTGGATCTTCTGCTATTATTTCATTTGACCTATCAAACGAAGCT TCCAAGAAATACAAAATCATAAAATTAGAATTTTTAAGTCCAGATAAAGGCAATTTTATTAACC AGCTAAGCAGCCTTACTAGTGGAAAACAGCAATCAAAAAAAGAGCTTGCAAAAGACGCTTACT CATTTGGTACATTAAGAACTGAATCTCTTTCAAAAACAATTGCAGAATATTACAAAGATAACAA CTGGTATTATATTTTAGCAGCAATAACAGTAGAAAATAATATAAATAAAGAAACTGAAAAATA CGAAATTAGAATTAACCCTAAAATATATAATGATTTTCAAAAAAAATTGAGATTACATTTTAAA AGCAACCAAATAAAAAAATTTCCAATACCCATTATAGAATAA t797.nt (SEQ ID NO:352) AAAAATAGCTTTTCTGAAAACGAAATTAATATCTTCGAAAACGAAAATTATATTGTAAA AGAAAATATAAAAACAGAAATTAAAAAACTAAAACAAAGTTTTTTACTTGCATCTGTTGATGTC GCCATTAGCCAACCCTACATAGAATTGGCAGATTTAAATGGAGAACCGATAAAAGAACTTGAA GGGATTAGTTATTCATTTATAAATGTATTTTCAAAAATTGGATCTTCTGCTATTATTTCATTTGA CCTATCAAACGAAGCTTCCAAGAAATACAAAATCATAAAATTAGAATTTTTAAGTCCAGATAAA GGCAATTTTATTAACCAGCTAAGCAGCCTTACTAGTGGAAAACAGCAATCAAAAAAAGAGCTT GCAAAAGACGCTTACTCATTTGGTACATTAAGAACTGAATCTCTTTCAAAAACAATTGCAGAAT ATTACAAAGATAACAACTGGTATTATATTTTAGCAGCAATAACAGTAGAAAATAATATAAATAA AGAAACTGAAAAATACGAAATTAGAATTAACCCTAAAATATATAATGATTTTCAAAAAAAATTG AGATTACATTTTAAAAGCAACCAAATAAAAAAATTTCCAATACCCATTATAGAATAA f799.aa (SEQ ID NO:353) MKKHIIIGIIFVAILLFFKILLIPRIQNHENNKNNIKMIISYKQDKNRLSLKINIKTKKTTNLGK AKLDIYLDSKLIESNLLYISSKNFTTYANIIYQNESLLSIILKSNGNNNVFYSKRIKPRGKI t799.aa (SEQ ID NO:354) HENNKNNIKMIISYKQDKNRLSLKINIKTKKTTNLGKAKLDIYLDSKLIESNLLYISSKNFTTYANIIY QNESLLSIILKSNGNNNVFYSKRIKPRGKI f799.nt (SEQ ID NO:355) ATGAAACATATCATTATTGGGATAATCTTTGTTGCAATTCTTTTATTTTTTAAAATTTTATT AATTCCCAGAATTCAAAATCACGAAAATAATAAAAATAATATCAAAATGATAATAAGCTACAA GCAAGACAAAAACAGATTATCGCTAAAGATAAACATAAAAACAAAAAAAACTACCAACCTGGG AAAAGCCAAACTAGATATTTATCTAGACAGTAAATTAATTGAAAGCAATTTGCTTTATATAAGC AGCAAAAACTTTACAACATATGCTAATATAATCTATCAAAATGAAAGTTTATTAAGTATAATAT TAAAGAGTAATGGCAATAATAATGTCTTTTATAGTAAAAGAATAAAACCTAGAGGTAAAATAT GA t799.nt (SEQ ID NO:356) CACGAAAATAATAAAAATAATATCAAAATGATAATAAGCTACAAGCAAGACAAAAACA GATTATCGCTAAAGATAAACATAAAAACAAAAAAAACTACCAACCTGGGAAAAGCCAAACTAG ATATTTATCTAGACAGTAAATTAATTGAAAGCAATTTGCTTTATATAAGCAGCAAAAACTTTAC AACATATGCTAATATAATCTATCAAAATGAAAGTTTATTAAGTATAATATTAAAGAGTAATGGC AATAATAATGTCTTTTTATAGTAAAAGAATAAAACCTAGAGGTAAAATATGA f800.aa (SEQ ID NO:357) MKKHYKALILSLLFAIISCNTKTLNELGEEQFKIPFGTLPGAIMPLNNKFTNSKFDIKTYNGL VYIAEIKTNKLMIFNSYGKLIQTYQNGIFKTNPDLKIKKIDFEGIQAIYPLKDFIIVADKLNNKKSKFN QKENIAYFMRILILNKNSSVEILGQEGLNGMPFPQIYDVNVDENGNIAIISIYSEGYIIYSYNKEFSPLY KIYVNKNLLKTIDNQKKKYNISIDKVFFEVNKKTLYVKTTYYENIGDNENINDLGIKIKDQYIYKMS LKKNKELEVINKIALPKNLLDDKQESFINIIKIQKDKIIASTNMKNLSNNLIWKLDSKGSIKEQIALIEP PNLMFLSESLSKDGILSILYGGKTGVSVYWWNLNALLKL t800.aa (SEQ ID NO:358) KTLNELGEEQFKIPFGTLPGAIMPLNNKFTNSKFDIKTYNGLVYIAEIKTNTKLMIFNSYGKLI QTYQNGIFKTNTPDLKIKKIDFEGIQAIYPLKDFIIVADKLNNKKSKFNQKENIAYFMRILILNKNSSVEI LGQEGLNGMPFPQIYDVNVDENGNIAIISIYSEGYIIYSYNKEFSPLYKIYVNKNLLKTIDNQKKKYNI SIDKVFFEVNKKTLYVKTYYYENIGDNENINDLGIKIKDQYIYKMSLKKNKELEVINKIALPKNLLDD KQESFINIIKIQKDKIIASTNMKNLSNNLIWKLDSKGSIKEQIALIEPPNLMFLSESLSKDGILSILYGGK TGVSVYWWNLNALLKL f800.nt (SEQ ID NO:359) ATGAAAAAACACTATAAAGCTCTTATATTAAGCTTGCTTTTTGCAATTATATCATGTAA TACTAAAACTTTAAACGAATTAGGAGAAGAACAATTTAAAATACCATTTGGAACACTTCCTGGT GCAATAATGCCTCTGAATAACAAATTTACAAATTCAAAATTTGACATCAAAACGTATAACGGGC TAGTGTACATTGCAGAAATAAAAACAAATAAATTAATGATTTTCAACTCATACGGAAAACTAAT ACAAACATATCAAAATGGAATATTTAAAACAAACCCCGATTTAAAAATAAAAAAAATAGATTTT GAAGGAATTCAAGCAATATACCCACTAAAAGATTTTATTATTGTCGCAGACAAACTAAATAATA AAAAATCAAAATTCAACCAAAAAGAGAATATTGCCTACTTCATGAGAATACTAATACTAAACAA AAACTCATCTGTAGAAATTTTGGGTCAAGAAGGTTTAAACGGAATGCCATTTCCACAAATTTAT GATGTTAATGTTGATGAAAATGGCAACATTGCAATAATATCAATATATAGCGAAGGATATATAA TATATTCTTACAATAAAGAATTTTCCCCGCTTTATAAAATTTACGTCAACAAAAACCTGTTAAAA ACAATAGACAATCAAAAGAAAAAATACAACATTTCAATAGATAAGGTTTTTTTTGAAGTCAACA AAAAAAAACTCTTTATGTAAAAACTACTTACTATGAAAACATTGGTGACAATGAAAATATAAACGA TCTTGGAATTAAAATTAAAGATCAATATATCTATAAAATGAGTTTGAAAAAAAACAAAGAATTA GAAGTGATAAATAAAATTGCTCTTCCTAAAAACTTACTAGATGATAAACAAGAAAGCTTTATAA ACATTATAAAAATACAAAAAGACAAAATAATAGCATCTACTAATATGAAAAATTTATCTAACAA TTTAATATGGAAATTAGACAGCAAGGGCTCAATTAAAGAACAAATAGCTTTAATTGAGCCTCCA AATTTAATGTTTCTCTCTGAGAGTTTATCTAAAGATGGAATACTTAGTATACTTTATGGCGGAA AAACTGGTGTTAGTGTTTACTGGTGGAATTTAAATGCATTATTAAAATTATAA t800.nt (SEQ ID NO:360) AAAACTTTAAACGAATTAGGAGAAGAACAATTTAAAATACCATTTGGAACACTTCCTG GTGCAATAATGCCTCTGAATAACAAATTTACAAATTCAAAATTTGACATCAAAACGTATAACGG GCTAGTGTACATTGCAGAAATAAAAACAAATAAATTAATGATTTTCAACTCATACGGAAAACTA ATACAAACATATCAAAATGGAATATTTAAAACAAACCCCGATTTAAAAATAAAAAAAATAGAT TTTGAAGGAATTCAAGCAATATACCCACTAAAAGATTTTATTATTGTCGCAGACAAACTAAATA ATAAAAAATCAAAATTCAACCAAAAAGAGAATATTGCCTACTTCATGAGAATACTAATACTAAA CAAAAACTCATCTGTAGAAATTTTGGGTCAAGAAGGTTTAAACGGAATGCCATTTCCACAAATT TATGATGTTAATGTTGATGAAAATGGCAACATTGCAATAATATCAATATATAGCGAAGGATATA TAATATATTCTTACAATAAAGAATTTTCCCCGCTTTATAAAATTTTACGTCAACAAAAACCTGTTA AAAACAATAGACAATCAAAAGAAAAAATACAACATTTCAATAGATAAGGTTTTTTTTGAAGTCA ACAAAAAAACTCTTTATGTAAAAACTACTTACTATGAAAACATTGGTGACAATGAAAATATAAA CGATCTTGGAATTAAAATTAAAGATCAATATATCTATAAAATGAGTTTGAAAAAAAACAAAGA ATTAGAAGTGATAAATAAAATTGCTCTTCCTAAAAACTTACTAGATGATAAACAAGAAAGCTTT ATAAACATTATAAAAATACAAAAAGACAAAATAATAGCATCTACTAATATGAAAAATTTATCTA ACAATTTAATATGGAAATTAGACAGCAAGGGCTCAATTAAAGAACAAATAGCTTTAATTGAGCC TCCAAATTTAATGTTTCTCTCTGAGAGTTTATCTAAAGATGGAATACTTAGTATACTTTATGGCG GAAAAACTGGTGTTAGTGTTTACTGGTGGAATTTAAATGCATTATTAAAATTATAA f810.aa (SEQ ID NO:361) MYKLFLFFIIFMFLSCDEKKSSKNLKSVKIGYVNWGGETAATNVLKVVFEKMGYNAEIFSV TTSIMYQYLASGKIDGTVSSWVPTADKFYYEKLKTKFVDLGANYEGTIQGFVVPSYVPISSISELKG KGDKFKNKMIGIDAGAGTQIVTEQALNYYGLSKEYELVPSSESVMLASLDSSIKRNEWILVPLWKPH WAFSRYDIKFLDDPDLIMGGIESVHTLVRLGLENDDFDAYYVFDHFYWSDDLILPLMDKNDKEPGK EYRNAVEFVEKNKEIVKTWVPEKYKTLFD t810.aa (SEQ ID NO:362) CDEKKSSKNLKSVKIGYVNWGGETAATNVLKVVFEKMGYNAEIFSVTTSIMYQYLASGKIDGTVSS WVPTADKFYYEKLKTKFVDLGANYEGTIQGFVVPSYVPISSISELKGKGDKFKNKMIGIDAGAGTQI VTEQALNYYGLSKEYELVPSSESVMLASLDSSIKRNEWILVPLWKPHWAFSRYDIKFLDDPDLIMGG IESVHTLVRLGLENDDFDAYYVFDHFYWSDDLILPLMDKNDKEPGKEYRNAVEFVEKNKEIVKTW VPEKYKTLFD f810.nt (SEQ ID NO:363) ATGTATAAATTATTTTTATTTTTTATTATTTTTATGTTTTTGTCTTGTGATGAAAAAAAG AGTTCAAAGAATTTAAAATCGGTAAAAATTGGATATGTGAATTGGGGTGGAGAAACGGCAGCT ACAAATGTATTAAAGGTTGTTTTTGAGAAAATGGGCTACAATGCAGAAATATTTTCAGTTACTA CGTCTATAATGTATCAATACTTAGCATCTGGAAAGATAGACGGTACGGTGTCTTCTTGGGTTCC TACAGCCGATAAATTTTATTATGAAAAACTGAAAACAAAGTTTGTTGATCTTGGTGCAAATTAT GAAGGAACCATTCAAGGTTTTGTGGTGCCAAGCTATGTTCCAATTTCCAGCATTAGTGAGCTTA AGGGTAAAGGTGATAAGTTTAAAAACAAAATGATTGGCATAGATGCTGGTGCGGGAACTCAAA TTGTTACAGAACAAGCGCTTAATTATTATGGATTAAGTAAAGAGTATGAGCTAGTTCCTTCAAG TGAGAGTGTTATGCTTGCAAGTTTAGATTCTTCAATAAAGAGAAACGAATGGATTTTAGTTCCT TTGTGGAAGCCTCATTGGGCTTTTTCTAGGTATGATATTAAGTTTCTTGATGATCCTGATTTAAT TATGGGGGGAATTGAGAGCGTGCATACTCTTGTTAGACTTGGTCTTGAAAATGATGATTTTGAT GCATATTATGTTTTTGATCATTTTTATTGGAGCGATGATTTAATATTGCCCTTAATGGATAAAAA TGATAAAGAGCCAGGCAAAGAATACCGCAATGCGGTTGAATTTGTTGAAAAGAATAAAGAGAT TGTAAAGACGTGGGTTCCAGAAAAATATAAGACCTTATTTGATTAA t810.nt (SEQ ID NO:364) TGTGATGAAAAAAAGAGTTCAAAGAATTTAAAATCGGTAAAAATTGGATATGTGAATT GGGGTGGAGAAACGGCAGCTACAAATGTATTAAAGGTTGTTTTTGAGAAAATGGGCTACAATG CAGAAATATTTTCAGTTACTACGTCTATAATGTATCAATACTTAGCATCTGGAAAGATAGACGG TACGGTGTCTTCTTGGGTTCCTACAGCCGATAAATTTTATTATGAAAAACTGAAAACAAAGTTT GTTGATCTTGGTGCAAATTATGAAGGAACCATTCAAGGTTTTGTGGTGCCAAGCTATGTTCCAA TTTCCAGCATTAGTGAGCTTAAGGGTAAAGGTGATAAGTTTAAAAACAAAATGATTGGCATAG ATGCTGGTGCGGGAACTCAAATTGTTACAGAACAAGCGCTTAATTATTATGGATTAAGTAAAGA GTATGAGCTAGTTCCTTCAAGTGAGAGTGTTATGCTTGCAAGTTTAGATTCTTCAATAAAGAGA AACGAATGGATTTTAGTTCCTTTGTGGAAGCCTCATTGGGCTTTTTCTAGGTATGATATTAAGTT TCTTGATGATCCTGATTTAATTATGGGGGGAATTGAGAGCGTGCATACTCTTGTTAGACTTGGT CTTGAAAATGATGATTTTGATGCATATTATGTTTTTGATCATTTTTATTGGAGCGATGATTTAAT ATTGCCCTTAATGGATAAAAATGATAAAGAGCCAGGCAAAGAATACCGCAATGCGGTTGAATT TGTTGAAAAGAATAAAGAGATTGTAAAGACGTGGGTTCCAGAAAAATATAAGACCTTATTTGA TTAA f814.aa (SEQ ID NO:365) MLVKRIVGKPITMLILFSLLLMISLYTFSRLKVDLLPGIDIPQISIHTVYPGASPREVEESVSRVLESGLS SVKNLKNIYSVSSKESSTVSLEFYHGTDLDLVLNEIRDALELVKSSLPSKSQTPRIFRYNLKNIPVMEI VINSVRPVSELKRYADEIIKPGLERLDGVAIVTVNGGSKKRVLIEVSQNRLESYGLSLSRISSIIASQNL ELSAGNILENNLEYLVEVSGKFKSIEEIGNVVIAYKIPDISSGINSPIEIKLKDIANIKTDFEDLSEYVE YNGLPSISLSVQKRSDSNSIAVSNVVMNEIEKLKLSMPKDMKLEIASDSTDFIKASISTVVNSAYFGA MLAIFVIFFFLRSFRATIIIGISIPIAIVLTFCLMYFVNISLNIMSLAGLALGIGMVVDCSIVVIDNIYKYR QKGAKLISSSILGAQEMMLPITSSTFTSICVFGPFLIFKSELGVYGDFFKDFTFTIVISLGVSLLVAIFLV PVLSSHYVGLYTSFQKNIKNAFIRKIDAFFASIYYFLEFLYINLLNIVLNHKLIFGLIVFFSFIGSLLLGLL LDVTTFTRGKENSITINLNFPHKTNLEYAKFYSNRFLEIVKSEAKGYKSIIATLRADRITFNVLFPLKEE SRDNLTQSVDYDSIKYKIMNRIGNLYPEFNIEPSISGNALGGGDSIKIKISANDFEYIKDYGKILVSML KKEIPELVNPRLSISDFQLQIGVEIDRALVYNYGIDMNTILNELKANINGVVAGQYVEKGLNYDIVLK LDRMDVKNLKDLEKIFITNSSGVKIPFSSIATFEKTNKAESIYRENQALTIYLNAGISPDDNLTQVTAK VVDFINNKVPHKEGITLKVEGEYNEFSNIMNQFKIIIMMAIIVVFGIMASQFESFLKPFIIIFTIPLTAIGV VLIHFLAGEKLSIFAAIGMLMLVGVVVNTGIVLVDYTGLLIKRGFGLREAIIESCRSRLRPILMSSLTSII GLIPMAFSSGSGNELLKPIAFTFIGGMTASTFLTLFFIPMLFEIFPTCFKFQI t814.aa (SEQ ID NO:366) RLKVDLLPGIDIPQISIHTVYPGASPREVEESVSRVLESGLSSVKNLKNIYSVSSKESSTVSLEF YHGTDLDLVLNEIRDALELVKSSLPSKSQTPRIFRYNLKNIPVMEIVINSVRPVSELKRYADEIIKPGL ERLDGVAIVTVNGGSKKRVLIEVSQNRLESYGLSLSRISSIIASQNLELSAGNILENNLEYLVEVSGKF KSIEEIGNVVIAYKIPDISSGINLSPIEIKLKDIANIKTDFEDLSEYVEYNGLPSISLSVQKRSDSNSIAVS NVVMNEIEKLKLSMPKDMKLEIASDSTDFIKASISTVVNSAYFGAMLAIFVIFFFLRSFPATIIIGISIPIA IVLTFCLMYFVNISLNIMSLAGLALGIGMVVDCSIVVIDNIYKYRQKGAKLISSSILGAQEMMLPITSS TFTSICVFGPFLIFKSELGVYGDFFKDFTFTIVISLGVSLLVAIFLVPVLSSHYVGLYTSFQKNIKNAFIR KIDAFFASIYYFLEFLYIINLLNIVLNHKLIFGLIVFFSFIGSLLLGLLLDVTTFTRGKENSITTNLNFPHKT NLEYAKFYSNRFLEIVKSEAKGYKSIIATLRADRITFNVLFPLKEESRDNLTQSVDYDSIKYKIMNRIG NLYPEFNIEPSISGNALGGGDSIKIKISANDFEYIKDYGKILVSMLKKEIPELVNPRLSISDFQLQIGVEI DRALVYNYGIDMNTILNEKLKANINGVVAGQYVEKGLNYDIVLKLDRMDVKNLKDLKIFITNSSGV KIPSSIATEKTNKAESIYRENQALTIYLNAGISDDNLTQVTAKVVDFINNKVPHKEGITLKVEGEY NEFSNIMNQFKIIIMMAIIVVFGIMASQFESFLKPFIIIFTIPLTAIGVVLIHFLAGEKLSIFAAIGMLMLV GVVVNTGIVLDYTGLLIKRGFGLREAIIESCRSRLRPILMSSLTSIIGLIPMAFSSGSGNELLKPIAFTFI GGMTASTFLTLFFIPMLFEIFPTCFKFQI f814.nt (SEQ ID NO:367) ATGTTGGTAAAGAGAATAGTTGGCAAACCAATAACAATGTTGATTTTATTTTCATTGTTATTGA TGATAAGTTTGTATACCTTTTCAAGATTAAAAGTAGATCTTTTGCCGGGAATTGACATTCCCCA AATAAGTATTCACACTGTTTATCCTGGCGCTTCTCCTAGAGAAGTTGAAGAGAGTGTTTCTAGA GTCCTTGAGAGTGGCTTGAGTTCGGTAAAGAATTTAAAAAATATATATAGTGTATCTTCCAAAG AAAGCAGCACCGTTTCACTTGAATTTTATCATGGAACCGATTTAGATTTGGTTTTAAATGAAAT TCGAGATGCTCTTGAATTGGTAAAATCTTCATTGCCCAGCAAATCACAGACCCCAAGAATTTTT AGATACAATCTTAAAAACATCCCTGTAATGGAAATTGTTATTAATTCTGTAAGGCCAGTTTCTG AGCTTAAAAGATATGCCGATGAAATCATTAAACCTGGGCTTGAAAGGCTTGATGGAGTTGCAAT TGTTACTGTTAATGGTGGAAGTAAAAAGCGTGTTTTAATTGAAGTTTCTCAAAACAGGCTGGAG TCTTATGGGCTTTCTTTGTCAAGAATATCTTCAATTATAGCATCCCAAAATTTGGAACTTTCAGC TGGCAATATATTGGAGAACAACTTGGAATATTTGGTTGAAGTTTCTGGAAAATTTAAATCAATT GAAGAGATAGGTAATGTGGTCATAGCTTATAAGATACCCGACATTTCTTCTGGCATAAATTTAT CTCCTATTGAGATAAAACTCAAAGATATTGCTAATATTAAAACCGATTTTGAAGATTTGTCTGA ATATGTTGAATATAATGGGTTGCCTTCAATTTCTTTGTCGGTTCAAAAACGTAGTGATTCTAATT CTATTGCAGTTTCTAATGTTGTTATGAATGAAATAGAAAAATTGAAATTATCTATGCCTAAAGA TATGAAATTGGAGATTGCTTCTGATAGTACTGATTTTATTAAAGCATCCATTTCAACGGTTGTA AATTCAGCCTATTTTGGGGCCATGCTTGCAATATTTGTTATTTTTTTCTTTTTAAGAAGCTTTAG GGCCACAATAATTATTGGAATTTCTATTCCAATAGCAATTGTTTTGACCTTTTGTTTAATGTATT TTGTAAATATTTCTCTTAATATTATGAGTCTTGCGGGTCTTGCACTTGGGATTGGAATGGTTGTT GACTGTTCAATTGTTGTAATAGACAATATATACAAATATAGGCAAAAAGGAGCAAAGCTTATTT CGTCTTCTATTCTCGGAGCTCAGGAGATGATGTTGCCTATTACATCTTCAACTTTTACTTCTATT TGTGTTTTTGGTCCATTTCTTATTTTCAAATCAGAACTTGGGGTATATGGAGATTTTTTCAAAGA CTTTACATTTACGATTGTTATTTCCTTGGGTGTTTCTCTTTTAGTTGCAATTTTTTTGGTTCCTGT TTTATCAAGCCACTATGTCGGTTTATACACAAGTTTCCAAAAGAATATTAAGAATGCTTTTATTA GGAAAATCGATGCCTTTTTTTGCTAGTATTTATTATTTTTTAGAGTTTTTGTATATCAATTTATTA AATATAGTTTTAAATCACAAATTGATTTTTGGGTTGATTGTTTTTTTTAGTTTTATTGGCAGCTT GCTTTTAGGATTATTGTTAGATGTGACAACTTTTACTAGAGGGAAAGAGAACTCAATTACTATT AATTTAAATTTTCCCCACAAAACTAATTTGGAATATGCAAAATTTTATTCTAATAGATTTTTAGA AATTGTAAAAAGTGAGGCTAAAGGATATAAAAGTATTATTGCTACTTTGCGTGCTGATAGAATA ACTTTCAACGTATTGTTTCCTCTCAAAGAAGAATCAAGAGATAATTTAACCCAAAGCGTAGATT ACGATTCTATTAAATATAAAATTATGAATCGTATTGGTAATCTTTATCCTGAATTTAATATTGAG CCTTCCATTAGTGGCAATGCTTTAGGTGGTGGAGATTCTATTAAAATTAAAATTTCGGCCAATG ATTTTGAATATATAAAAGATTATGGAAAAATTTTAGTTTCCATGTTAAAAAAGGAAATTCCCGA ACTTGTAAATCCAAGGCTTAGCATAAGTGATTTTCAGCTTCAAATTGGCGTTGAGATAGACAGA GCGCTAGTTTATAATTATGGTATTGACATGAATACCATTTTAAATGAGTTGAAGGCCAATATTA ATGGTGTTGTTGCTGGGCAATATGTGGAGAAGGGACTTAATTATGATATTGTTCTTAAGCTTGA TAGAATGGATGTTAAAAATTTAAAAGATTTAGAAAAAATATTTATTACAAATTCATCTGGAGTT AAAATTCCTTTTTCATCAATAGCCACCTTTGAAAAAACCAATAAAGCCGAATCTATTTACAGAG AAAATCAAGCTTTAACCATTTATCTTAATGCGGGTATTTCTCCAGATGATAATTTAACCCAAGT AACCGCAAAAGTTGTAGATTTTATTAATAATAAGGTGCCCCATAAAGAAGGCATAACTCTTAAG GTTGAAGGAGAATATAATGAATTTTCAAATATCATGAATCAGTTTAAAATAATCATTATGATGG CTATTATTGTTGTGTTTGGTATTATGGCTTCTCAATTTGAATCTTTTTTAAAACCCTTTATTATTA TTTTACAATTCCTTTAACGGCAATAGGGGTTGTGCTTATACATTTTCTTGCAGGAGAAAAGCTT TCTATTTTTGCTGCAATTGGTATGCTTATGCTTGTTGGTGTTGTGGTAAATACAGGAATTGTTCT TGTAGACTATACTGGTTTATTGATCAAGAGGGGATTTGGCCTAAGAGAAGCAATTATTGAATCT TGTCGTTCAAGGCTTAGGCCAATTTTAATGTCTTCTTTGACCTCAATAATAGGGCTTATTCCAAT GGCATTTTCTAGCGGAAGTGGAAATGAACTTCTAAAACCAATTGCATTTACTTTTATTGGCGGA ATGACAGCTAGCACATTTCTTACTTTGTTTTTTATTCCCATGCTTTTTGAAATTTTTCCAACATGT TTCAAGTTTCAAATCTAG t814.nt (SEQ ID NO:368) AGATTAAAAGTAGATCTTTTGCCGGGAATTGACATTCCCCAAATAAGTATTCACACTGTTTATC CTGGCGCTTCTCCTAGAGAAGTTGAAGAGAGTGTTTCTAGAGTCCTTGAGAGTGGCTTGAGTTC GGTAAAGAATTTAAAAAATATATATAGTGTATCTTCCAAAGAAAGCAGCACCGTTTCACTTGAA TTTTATCATGGAACCGATTTAGATTTGGTTTTAAATGAAATTCGAGATGCTCTTGAATTGGTAA AATCTTCATTGCCCAGCAAATCACAGACCCCAAGAATTTTTAGATACAATCTTAAAAACATCCC TGTAATGGAAATTGTTATTAATTCTGTAAGGCCAGTTTCTGAGCTTAAAAGATATGCCGATGAA ATCATTAAACCTGGGCTTGAAAGGCTTGATGGAGTTGCAATTGTTACTGTTAATGGTGGAAGTA AAAAGCGTGTTTTAATTGAAGTTTCTCAAAACAGGCTGGAGTCTTATGGGCTTTCTTTGTCAAG AATATCTTCAATTATAGCATCCCAAAATTTGGAACTTTCAGCTGGCAATATATTGGAGAACAAC TTGGAATATTTGGTTGAAGTTTCTGGAAAATTTAAATCAATTGAAGAGATAGGTAATGTGGTCA TAGCTTATAAGATACCCGACATTTCTTCTGGCATAAATTTATCTCCTATTGAGATAAAACTCAAA GATATTGCTAATATTAAAACCGATTTTGAAGATTTGTCTGAATATGTTGAATATAATGGGTTGC CTTCAATTTCTTTGTCGGTTCAAAAACGTAGTGATTCTAATTCTATTGCAGTTTCTAATGTTGTT ATGAATGAAATAGAAAAATTGAAATTATCTATGCCTAAAGATATGAAATTGGAGATTGCTTCTG ATAGTACTGATTTTATTAAAGCATCCATTTCAACGGTTGTAAATTCAGCCTATTTTGGGGCCATG CTTGCAATATTTGTTATTTTTTTCTTTTTAAGAAGCTTTAGGGCCACAATAATTATTGGAATTTC TATTCCAATAGCAATTGTTTTGACCTTTTGTTTAATGTATTTTGTAAATATTTCTCTTAATATTAT GAGTCTTGCGGGTCTTGCACTTGGGATTGGAATGGTTGTTGACTGTTCAATTGTTGTAATAGAC AATATATACAAATATAGGCAAAAAGGAGCAAAGCTTATTTCGTCTTCTATTCTCGGAGCTCAGG AGATGATGTTGCCTATTACATCTTCAACTTTTACTTCTATTTGTGTTTTTGGTCCATTTCTTATTT TCAAATCAGAACTTGGGGTATATGGAGATTTTTTCAAAGACTTTACATTTACGATTGTTATTTCC TTGGGTGTTTCTCTTTTAGTTGCAATTTTTTTGGTTCCTGTTTTATCAAGCCACTATGTCGGTTTA TACACAAGTTTCCAAAAGAATATTAAGAATGCTTTTATTAGGAAAATCGATGCCTTTTTTTGCTA GTATTTATTATTTTTTAGAGTTTTTGTATATCAATTTATTAAATATAGTTTTAAATCACAAATTG ATTTTTGGGTTGATTGTTTTTTTTAGTTTTATTGGCAGCTTGCTTTTAGGATTATTGTTAGATGTG ACAACTTTTACTAGAGGGAAAGAGAACTCAATTACTATTAATTTAAATTTTCCCCACAAAACTA ATTTGGAATATGCAAAATTTTATTCTAATAGATTTTTAGAAATTGTAAAAAGTGAGGCTAAAGG ATATAAAAGTATTATTGCTACTTTGCGTGCTGATAGAATAACTTTCAACGTATTGTTTCCTCTCA AAGAAGAATCAAGAGATAATTTAACCCAAAGCGTAGATTACGATTCTATTAAATATAAAATTAT GAATCGTATTGGTAATCTTTATCCTGAATTTAATATTGAGCCTTCCATTAGTGGCAATGCTTTAG GTGGTGGAGATTCTATTAAAATTAAAATTTCGGCCAATGATTTTGAATATATAAAAGATTATGG AAAAATTTTAGTTTCCATGTTAAAAAAGGAAATTCCCGAACTTGTAAATCCAAGGCTTAGCATA AGTGATTTTCAGCTTCAAATTGGCGTTGAGATAGACAGAGCGCTAGTTTATAATTATGGTATTG ACATGAATACCATTTTAAATGAGTTGAAGGCCAATATTAATGGTGTTGTTGCTGGGCAATATGT GGAGAAGGGACTTAATTATGATATTGTTCTTAAGCTTGATAGAATGGATGTTAAAAATTTAAAA GATTTAGAAAAAATATTTATTACAAATTCATCTGGAGTTAAAATTCCTTTTTCATCAATAGCCAC CTTTGAAAAAACCAATAAAGCCGAATCTATTTACAGAGAAAATCAAGCTTTAACCATTTATCTT AATGCGGGTATTTCTCCAGATGATAATTTAACCCAAGTAACCGCAAAAGTTGTAGATTTTATTA ATAATAAGGTGCCCCATAAAGAAGGCATAACTCTTAAGGTTGAAGGAGAATATAATGAATTTTC AAATATCATGAATCAGTTTAAAATAATCATTATGATGGCTATTATTGTTGTGTTTGGTATTATGG CTTCTCAATTTGAATCTTTTTTAAAACCCTTTATTATTATTTTTACAATTCCTTTAACGGCAATAG GGGTTGTGCTTATACATTTTCTTGCAGGAGAAAAGCTTTCTATTTTTGCTGCAATTGGTATGCTT ATGCTTGTTGGTGTTGTGGTAAATACAGGAATTGTTCTTGTAGACTATACTGGTTTATTGATCAA GAGGGGATTTGGCCTAAGAGAAGCAATTATTGAATCTTGTCGTTCAAGGCTTAGGCCAATTTTA ATGTCTTCTTTGACCTCAATAATAGGGCTTATTCCAATGGCATTTTCTAGCGGAAGTGGAAATG AACTTCTAAAACCAATTGCATTTACTTTTATTGGCGGAATGACAGCTAGCACATTTCTTACTTTG TTTTTTATTCCCATGCTTTTTGAAATTTTTCCAACATGTTTCAAGTTTCAAATCTAG f818.aa (SEQ ID NO:369) MLKNHSKLIIQLKVVMMIYLKKMGNDMTKFYNYRIEIVSNLSLELDVFECIEKIEQELGESIYYSKIG NVYGKGKKGEKHGNGVWPEENFILIIYTSNQSIVERLKDIVDDLNRSYPTEGINLFVLRNS t818.aa (SEQ ID NO:370) KKMGNDMTKFYNYRIEIVSNLSLELDVFECIEKIEQELGESIYYSKIGNVYGKGKKGEKHG NGVWPEENFILIIYTSNQSIVERLKDIVDDLNRSYPTEGINLFVLRNS f818.nt (SEQ ID NO:371) ATGTTGAAAAATCATTCAAAATTAATAATTCAACTAAAAGTAGTTATGATGATTTATTTGAAGA AGATGGGGAATGATATGACTAAATTTTATAATTATAGGATTGAAATAGTTTCTAACTTATCTTT AGAGCTTGATGTTTTTGAATGTATAGAAAAAATAGAGCAAGAGTTAGGAGAGTCTATATATTAT TCTAAGATAGGAAATGTTTATGGAAAAGGTAAGAAGGGAGAAAAGCATGGTAATGGCGTTTGG CCTGAAGAAAATTTTATTTTGATTATTTATACCTCCAATCAGTCTATTGTTGAGCGATTAAAGGA TATTGTGGATGATTTGAATCGTTCTTACCCTACAGAAGGGATTAATCTTTTTGTTTTGAGAAATT CTTAA t818.nt (SEQ ID NO:372) AAGAAGATGGGGAATGATATGACTAAATTTTATAATTATAGGATTGAAATAGTTTCTAACTTAT CTTTAGAGCTTGATGTTTTTGAATGTATAGAAAAAATAGAGCAAGAGTTAGGAGAGTCTATATA TTATTCTAAGATAGGAAATGTTTATGGAAAAGGTAAGAAGGGAGAAAAGCATGGTAATGGCGT TTGGCCTGAAGAAAATTTTATTTTGATTATTTATACCTCCAATCAGTCTATTGTTGAGCGATTAA AGGATATTGTGGATGATTTGAATCGTTCTTACCCTACAGAAGGGATTAATCTTTTTGTTTTGAG AAATTCTTAA f820.aa (SEQ ID NO:373) MLNNTYRIKTILTIFLAITLLTIYKYFTLMAFNNSPDNTISLKSNDIAKRGTIYDRNGKPIAFSSKSYSIG TNPQKIENIVSTSETLGAILQINSRILKEKLSSNKGFLYIKRKIKREESDLIKRIQAEGRLSNITLYPDYT RIYPFRNTTSNITGFVGTDNLGLEGIEFSLNSILGKDKTKQQFLNEEPETNNIHLTIDMDIQQGVSKIA KKYFKENNPESLITLVMNSQNGEILSMVQFPQYDANFYSKYPEEIRKNLSSSLTYEPGSINKIFTVAIIL ESGKLNLEEKFLDNGIYQKQFPSGEKITIKTLNPPYKHIDSTEILIYSSNVGIAYITEKVSNEYFYKKLL DFGFGEKVGVPFPGETKGLLNHYSKWSGRSKATIGFGQEIGVSAVQILQAASILSNNGIMLKPRIIKKI SNDKGENIKEFDKEEIRKVISKNSAQKVLKMMREVVNKGGIPNLKIKNLDISAKSGTSQAIDRKTGK YSEEDYTSSILAIYPTEQPKYIIYIVYRYPKKIIYGTRIAAPMAKEIIEFIEHQQNTIAYKKIKMPSKIIKIP KAETNYKNKTYLPNFINLSKREAIDILKYYKNTMKIKINGDGFVYKQSISPNTKLEDITELELYLK t820.aa (SEQ ID NO:374) FNNSPDNTISLKSNDIAKRGTIYDRNGKPIAFSSKSYSIGTNPQKIENIVSTSETLGAILQINSRI LKEKLSSNKGFLYIKRKIKREESDLIKRIQAEGRLSNITLYPDYTRIYPFRNTTSNITGFVGTDNLGLEG IEFSLNSILGKDKTKQQFLNEEPETNNIHLTIDMDIQQGVSKIAKKYFKENNPESLITLVMNSQNGEIL SMVQFPQYDANFYSKYPEEIRKNLSSSLTYEPGSINKIFTVAIILESGKLNLEEKFLDNGIYQKQFPSG EKITIKTLNPPYKHIDSTEILIYSSNVGIAYITEKVSNEYFYKKLLDFGFGEKVGVPFPGETKGLLNHY SKWSGRSKATIGFGQEIGVSAVQILQAASILSNNGIMLKPRIIKKISNDKGENIKEFDKEEIRKVISKNS AQKVLKMMREVVNKGGIPNLKIKNLDISAKSGTSQAIDRKTGKYSEEDYTSSILAIYPTEQPKYIIYIV YRYPKKIIYGTRIAAPMAKEIIEFIEHQQNTIAYKKIKMPSKIKIPKAETNYKNKTYLPNFINLSKREAEI DILKYYKNTMKIKINGDGFVYKQSISPNTKLEDITELELYLK f820.nt (SEQ ID NO:375) ATGCTTAATAACACTTATCGAATAAAAACAATATTAACAATATTCTTGGCTATAACTTTGTTAAC TATTTACAAATATTTCACACTAATGGCCTTCAATAACAGCCCAGACAACACAATATCTTTAAAG TCAAATGATATTGCCAAAAGAGGAACAATTTATGATAGAAATGGCAAACCAATAGCATTCTCTT CAAAATCCTACTCAATTGGTACAAATCCTCAAAAAATAGAAAATATTGTAAGCACATCTGAAAC TCTTGGTGCAATACTTCAAATTAATTCAAGAATTTTAAAGGAAAAGCTTCCTCTAACAAAGGG TTTTTATATATAAAAAGAAAAATAAAAAGAGAAGAATCAGATTTAATAAAAAGAATTCAAGCT GAAGGCAGGCTTTCAAACATCACTTTATATCCTGATTACACAAGAATTTATCCCTTCAGGAATA CCACAAGCAATATTACTGGTTTTGTAGGAACAGATAATCTTGGCCTTGAGGGCATTGAATTTTC CCTAAATAGCATATTAGGAAAAGATAAAACCAAGCAACAATTTTTAAATGAGGAGCCAGAAAC AAACAACATCCACTTAACAATAGACATGGATATACAACAAGGTGTTAGCAAAATAGCTAAAAA ATACTTTAAAGAAAATAATCCTGAAAGTTTAATTACCTTGGTAATGAACTCCCAAAATGGAGAA ATATTATCCATGGTTCAATTTCCTCAATATGATGCAAACTTTTATTCTAAATATCCTGAAGAAAT CCGAAAAAACCTTTCTTCATCTCTAACCTATGAGCCCGGAAGCATTAATAAAATTTTTACAGTT GCAATAATATTAGAAAGTGGAAAATTAAATTTAGAAGAAAAATTTTTAGACAATGGAATATAT CAAAAACAATTTCCATCAGGAGAAAAAATTACAATCAAAACATTAAATCCCCCCTATAAACATA TCGACTCTACAGAGATTTTAATTTATTCATCAAATGTTGGAATAGCTTACATTACTGAAAAAGT TAGCAATGAATACTTTTATAAAAAACTTTTAGATTTTGGCTTTGGGGAAAAAGTTGGAGTTCCA TTTCCCGGAGAAACAAAAGGACTGCTAAATCATTATTCAAAATGGTCAGGACGAAGTAAAGCT ACAATTGGATTTGGACAAGAAATAGGAGTGTCAGCGGTTCAAATATTACAAGCTGCAAGCATA CTAAGCAATAATGGAATAATGCTAAAACCTAGAATAATAAAAAAAATAAGCAACGATAAAGGA GAAAATATTAAAGAATTTGATAAAGAAGAAATAAGAAAAGTAATATCCAAAAATTCAGCACAA AAAGTTTTAAAAATGATGAGAGAAGTTGTAAATAAAGGTGGAATTCCAAATCTTAAAATTAAA AATCTTGACATTTCTGCAAAAAGTGGAACATCTCAAGCTATTGATAGAAAAACGGGAAAATACT CAGAAGAAGACTATACATCTTCTATATTGGCAATATACCCCACAGAACAACCAAAATATATTAT TTACATTGTATACAGATACCCAAAAAAAATAATATACGGAACAAGAATAGCAGCCCCAATGGC AAAAGAAATAATAGAATTTATTGAGCACCAACAAAATACAATAGCATATAAAAAAATTAAAAT GCCATCAAAAATCAAGATCCCTAAAGCTGAAACTAATTACAAAAACAAAACATACTTACCAAAT TTTATCAACCTTTCTAAAAGAGAAGCAATAGACATACTAAAATACTATAAAAATACTATGAAAA TAAAAATAAATGGCGATGGATTTGTTTACAAGCAAAGTATATCCCCCAATACAAAATTAGAAGA TATAACAGAGCTTGAACTGTATTTAAAATAA t820.nt (SEQ ID NO:376) TTCAATAACAGCCCAGACAACACAATATCTTTAAAGTCAAATGATATTGCCAAAAGAGGAACA ATTTATGATAGAAATGGCAAACCAATAGCATTCTCTTCAAAATCCTACTCAATTGGTACAAATC CTCAAAAAATAGAAAATATTGTAAGCACATCTGAAACTCTTGGTGCAATACTTCAAATTAATTC AAGAATTTTAAAGGAAAAGCTTTCCTCTAACAAAGGGTTTTTATATATAAAAAGAAAAATAAAA AGAGAAGAATCAGATTTAATAAAAAGAATTCAAGCTGAAGGCAGGCTTTCAAACATCACTTTAT ATCCTGATTACACAAGAATTTATCCCTTCAGGAATACCACAAGCAATATTACTGGTTTTGTAGG AACAGATAATCTTGGCCTTGAGGGCATTGAATTTTCCCTAAATAGCATATTAGGAAAAGATAAA ACCAAGCAACAATTTTTAAATGAGGAGCCAGAAACAAACAACATCCACTTAACAATAGACATG GATATACAACAAGGTGTTAGCAAAATAGCTAAAAAATACTTTAAAGAAAATAATCCTGAAAGT TTAATTACCTTGGTAATGAACTCCCAAAATGGAGAAATATTATCCATGGTTCAATTTCCTCAAT ATGATGCAAACTTTTATTCTAAATATCCTGAAGAAATCCGAAAAAACCTTTCTTCATCTCTAACC TATGAGCCCGGAAGCATTAATAAAATTTTTACAGTTGCAATAATATTAGAAAGTGGAAAATTAA ATTTAGAAGAAAAA TTTTTAGACAATGGAATATATCAAAAACAATTTCCATCAGGAGAAAAAA TTACAATCAAAACATTAAATCCCCCCTATAAACATATCGACTCTACAGAGATTTTAATTTATTCA TCAAATGTTGGAATAGCTTACATTACTGAAAAAGTTAGCAATGAATACTTTTATAAAAAACTTT TAGATTTTGGCTTTGGGGAAAAAGTTGGAGTTCCATTTCCCGGAGAAACAAAAGGACTGCTAAA TCATTATTCAAAATGGTCAGGACGAAGTAAAGCTACAATTGGATTTGGACAAGAAATAGGAGT GTCAGCGGTTCAAATATTACAAGCTGCAAGCATACTAAGCAATAATGGAATAATGCTAAAACCT AGAATAATAAAAAAAATAAGCAACGATAAAGGAGAAAATATTAAAGAATTTGATAAAGAAGA AATAAGAAAAGTAATATCCAAAAATTCAGCACAAAAAGTTTTAAAAATGATGAGAGAAGTTGT AAATAAAGGTGGAATTCCAAATCTTAAAATTAAAAATCTTGACATTTCTGCAAAAAGTGGAACA TCTCAAGCTATTGATAGAAAAACGGGAAAATACTCAGAAGAAGACTATACATCTTCTATATTGG CAATATACCCCACAGAACAACCAAAATATATTATTTACATTGTATACAGATACCCAAAAAAAAT AATATACGGAACAAGAATAGCAGCCCCAATGGCAAAAGAAATAATAGAATTTATTGAGCACCA ACAAAATACAATAGCATATAAAAAAATTAAAATGCCATCAAAAATCAAGATCCCTAAAGCTGA AACTAATTACAAAAACAAAACATACTTACCAAATTTTATCAACCTTTCTAAAAGAGAAGCAATA GACATACTAAAATACTATAAAAATACTATGAAAATAAAAATAAATGGCGATGGATTTGTTTACA AGCAAAGTATATCCCCCAATACAAAATTAGAAGATATAACAGAGCTTGAACTGTATTTAAAATA A f831.aa (SEQ ID NO:377) MAKNNLLVFFIAIIFVFVSIIVVFYNSLGKDYVKSGGEIVENLEKDLNDYLKENDAKEREKIFLRIRELI SKEKEISSYFISRFYLARAVYFQSQAQYDEAIKDLDIVIKAKGIESEIAFLNKAAVYEKMGLKEDALL VYEDLINSTSLDFLKVRALLSKAILIEEKDKELAVKVYEEIVKFPYENNLYINMANNKILELKQN t831.aa (SEQ ID NO:378) YNSLGKDYVKSGGEIVENLEKDLNDYLKENDAKEREKIFLRIRELISKEKEISSYFISRFYLARAVYFQ SQAQYDEAIKDLDIVIKAKGIESEIAFLNKAAVYEKMGLKEDALLVYEDLINSTSLDFLKVRALLSKA ILIEEKDKELAVKVYEEIVKFPYENNLYINMANNKILELKQN f831.nt (SEQ ID NO:379) ATGGCTAAAAATAATCTTTTAGTTTTCTTTATTGCTATTATTTTTGTGTTTGTGTCTATTATTGTT GTTTTTTATAATTCTTTAGGCAAGGATTATGTAAAGAGTGGCGGAGAAATAGTAGAAAATCTTG AAAAAGATTTAAATGATTATTTAAAAGAAAATGATGCCAAAGAGAGAGAAAAAATATTTCTTA GGATAAGGGAGCTTATTTCAAAGGAAAAAGAAATTTCATCTTATTTTATTTCAAGGTTCTATTT AGCCAGAGCTGTTTATTTCCAAAGTCAAGCACAGTATGATGAGGCTATTAAAGATTTAGATATT GTTATTAAGGCAAAAGGTATTGAAAGTGAAATTGCTTTTCTTAATAAAGCTGCAGTTTATGAAA AAATGGGATTAAAAGAAGATGCTTTGTTAGTTTATGAAGATCTTATCAATAGTACTAGTTTGGA TTTTTTAAAGGTAAGAGCTCTTTTGAGTAAGGCAATATTGATTGAGGAAAAAGATAAAGAGCTT GCTGTGAAAGTATACGAAGAGATTGTTAAGTTTCCGTATGAAAATAATTTATATATAAATATGG CAAATAATAAAATTTTAGAACTTAAGCAAAATTAA t831.nt (SEQ ID NO:380) TATAATTCTTTAGGCAAGGATTATGTAAAGAGTGGCGGAGAAATAGTAGAAAATCTTGAAAAA GATTTAAATGATTATTTAAAAGAAAATGATGCCAAAGAGAGAGAAAAAATATTTCTTAGGATA AGGGAGCTTATTTCAAAGGAAAAAGAAATTTCATCTTATTTTATTTCAAGGTTCTATTTAGCCA GAGCTGTTTATTTCCAAAGTCAAGCACAGTATGATGAGGCTATTAAAGATTTAGATATTGTTAT TAAGGCAAAAGGTATTGAAAGTGAAATTGCTTTTCTTAATAAAGCTGCAGTTTATGAAAAAATG GGATTAAAAGAAGATGCTTTGTTAGTTTATGAAGATCTTATCAATAGTACTAGTTTGGATTTTTT AAAGCTAAGAGCTCTTTTGAGTAAGGCAATATTGATTGAGGAAAAAGATAAAGAGCTTGCTGT GAAAGTATACGAAGAGATTGTTAAGTTTCCGTATGAAAATAATTTATATATAAATATGGCAAAT AATAAAATTTTAGAACTTAAGCAAAATTAA f843.aa (SEQ ID NO:381) MKAIGNAILLNMPLIFSIGISIGVARMGQGTAALGGLIGYLTFNITENYFIEAFSGLVEAETMSSVGRI NFFGVQTLNTGIAGSLAVGLLVGYLHNKFYNMKLPKPFVFFSECHFVPIVIILPFCVFLAIFFCLIWSSF DDLIASLGLFVFRFEYFGSFLYGFLNRLLLPLGLRSILSFPFEFTSLGGVEIVNGDTVRGLKNIFYAQLL DPSLGKFSSGFAKISSGFYLSIMFGLPGAALGVYKGIVHEDKNKVAALLFSGALTAFLTGITEPLEFLF IFTAPLLYFVHAAYSGFALLLANFFNVTIGNSFSTGFLDFFMFGILQGNSKTNWISVLPLGAMFFALY YFTFSWLYRYFDFQIFVTDDPFFEGQEGKLESLGIAHLLIQGLGGFDNITKLDVCSTRLHVDVVNTEL VDNNLLKEAGVLKIGLVNGKVQLFYGSNVYYIKNAIDTYSPKSLFEASVMVAVDNVKKGFKTYIE MKEDKKLEKQGKSGKTYKLSELEED t843.aa (SEQ ID NO:382) RMGQGTAALGGLIGYLTFNITENYFIEAFSGLVEAETMSSVGRINFFGVQTLNTGIAGSLAVGLLVG YLHNKFYNMKLPKPFVFFSECHFVPIVIILPFCVFLAIFFCLIWSSFDDLIASLGLFVFRFEYFGSFLYGF LNRLLLPLGLHSILSFPFEFTSLGGVEIVNGDTVRGLKNFYAQLLDPSLGKFSSGFAKISSGFYLSIMF GLPGAALGVYKGIVHEDKNKVAALLFSGALTAFLTGITEPLEFLFIFTAPLLYFVHAAYSGFALLLAN FFNVTIGNSFSTGFLDFFMFGILQGNSKTNWISVLPLGAMFFALYYFTFSWLYRYFDFQIFVTDDPFF EGQEGKLESLGIAHLLIQGLGGFDNITKLDVCSTRLHVDVVNTELVDNNLLKEAGVLKIGLVNGKV QLFYGSNVYYIKNAIDTYSPKSLFEASVMVAVDNVKKGFKTYIEMKEDKKLEKQGKSGKTYKLSEL EED f843.nt (SEQ ID NO:383) ATGAAGGCTATAGGCAATGCTATTCTTCTCAATATGCCTTTAATTTTTTCTATTGGAATTTCTAT TGGAGTTGCAAGAATGGGGCAGGGAACAGCGGCTTTGGGAGGCCTTATTGGTTATTTAACATTT AATATTACTGAAAATTATTTTATTGAGGCTTTTTCAGGGCTTGTTGAAGCAGAGACAATGTCTT CTGTTGGGCGTATAAATTTTTTTGGTGTTCAAACTTTAAATACGGGAATTGCAGGTTCTTTAGCG GTAGGCCTTTTAGTTGGATATTTGCATAACAAATTTTATAATATGAAGCTACCCAAACCTTTTGT GTTTTTTTCAGAGTGCCATTTTGTGCCTATAGTAATAATTTTACCCTTTTGTGTTTTTTTGGCTAT ATTTTTTTGTTTGATTTGGTCAAGTTTTGACGATTTAATTGCATCTTTAGGTTTGTTTGTTTTTAG GTTTGAATATTTTGGCAGTTTTCTTTATGGATTTTTAAATAGGCTTTTATTGCCTTTGGGGTTGC ATTCTATTTTATCTTTTCCTTTTGAGTTTACTTCTTTGGGAGGAGTGGAGATAGTTAATGGCGAT ACTGTTAGAGGTCTTAAGAATATATTTTATGCTCAGCTATTAGACCCATCACTTGGTAAATTTTC ATCAGGCTTTGCCAAAATTAGCAGTGGATTTTATCTATCTATTATGTTTGGACTGCCCGGAGCA GCATTAGGGGTTTACAAGGGTATTGTTCATGAAGATAAAAATAAGGTTGCAGCACTTCTTTTCT CTGGGGCCTTGACAGCTTTTTTAACAGGAATAACTGAGCCTTTAGAATTTTTATTTATTTTCACA GCGCCTTTGCTTTATTTTGTTCATGCCGCTTATTCGGGGTTTGCATTGTTGCTTGCTAATTTTTTT AATGTTACGATTGGCAATAGCTTTTCTACTGGATTTTTGGATTTTTTTATGTTTGGGATACTTCA AGGAAATTCTAAGACAAATTGGATTAGTGTATTACCTTTGGGGGCAATGTTTTTTGCTCTTTATT ATTTTACTTTTAGTTGGCTTTATAGATACTTTGATTTTCAGATATTTGTTACAGACGATCCATTT TTTGAAGGCCAAGAAGGAAAGCTAGAGAGTCTCGGAATTGCGCATCTTTTAATTCAAGGTCTTG GTGGATTTGATAATATTACAAAGCTTGATGTTTGTTCTACAAGATTGCATGTAGATGTTGTTAA TACTGAGCTTGTTGATAATAATTTGCTTAAAGAGGCTGGAGTTCTTAAAATAGGGCTTGTTAAT GGCAAGGTTCAGCTTTTTTATGGATCTAATGTTTATTATATTAAAAATGCCATTGATACCTATTC TCCAAAGAGTCTTTTTGAAGCTAGTGTTATGGTTGCAGTTGATAATGTAAAAAAAGGTTTTAAA ACTTATATTGAAATGAAAGAAGACAAAAAACTTGAAAAGCAAGGTAAATCAGGAAAAACCTAT AAGCTTAGCGAATTAGAAGAAGATTAG t843.nt (SEQ ID NO:384) AGAATGGGGCAGGGAACAGCGGCTTTGGGAGGCCTTATTGGTTATTTAACATTTAATATTACTG AAAATTATTTTATTGAGGCTTTTTCAGGGCTTGTTGAAGCAGAGACAATGTCTFTCTGTTGGGCG TATAAATTTTTTTGGTGTTCAAACTTTAAATACGGGAATTGCAGGTTCTTTAGCGGTAGGCCTTT TAGTTGGATATTTGCATAACAAATTTTATAATATGAAGCTACCCAAACCTTTTGTGTTTTTTTCA GAGTGCCATTTTGTGCCTATAGTAATAATTTTACCCTTTTGTGTTTTTTTGGCTATATTTTTTTGT TTGATTTGGTCAAGTTTTGACGATTTAATTGCATCTTTAGGTTTTGTTTGTTTTTAGGTTTGAATA TTTTGGCAGTTTTCTTTATGGATTTTTAAATAGGCTTTTATTGCCTTTGGGGTTGCATTCTATTTT ATCTTTTCCTTTTGAGTTTACTTCTTTGGGAGGAGTGGAGATAGTTAATGGCGATACTGTTAGA GGTCTTAAGAATATATTTTATGCTCAGCTATTAGACCCATCACTTGGTAAATTTTCATCAGGCTT TGCCAAAATTAGCAGTGGATTTTATCTATCTATTATGTTTGGACTGCCCGGAGCAGCATTAGGG GTTTACAAGGGTATTGTTCATGAAGATAAAAATAAGGTTGCAGCACTTCTTTTCTCTGGGGCCT TGACAGCTTTTTTAACAGGAATAACTGAGCCTTTAGAATTTTTATTTATTTTCACAGCGCCTTTG CTTTATTTTGTTCATGCCGCTTATTCGGGGTTTGCATTGTTGCTTGCTAATTTTTTTAATGTTACG ATTGGCAATAGCTTTTCTACTGGATTTTTGGATTTTTTTATGTTTGGGATACTTCAAGGAAATTC TAAGACAAATTGGATTAGTGTATTACCTTTGGGGGCAATGTTTTTTGCTCTTTATTATTTTACTT TTAGTTGGCTTTATAGATACTTTGATTTTCAGATATTTGTTACAGACGATCCATTTTTTGAAGGC CAAGAAGGAAAGCTAGAGAGTCTCGGAATTGCGCATCTTTTAATTCAAGGTCTTGGTGGATTTG ATAATATTACAAAGCTTGATGTTTGTTCTACAAGATTGCATGTAGATGTTGTTAATACTGAGCTT GTTGATAATAATTTGCTTAAAGAGGCTGGAGTTCTTAAAATAGGGCTTGTTAATGGCAAGGTTC AGCTTTTTTATGGATCTAATGTTTATTATATTAAAAATGCCATTGATACCTATTCTCCAAAGAGT CTTTTTGAAGCTAGTGTTATGGTTGCAGTTGATAATGTAAAAAAAGGTTTTAAAACTTATATTG AAATGAAAGAAGACAAAAAACTTGAAAAGCAAGGTAAATCAGGAAAAACCTATAAGCTTAGCG AATTAGAAGAAGATTAG f850.aa (SEQ ID NO:385) MRFKKIFLIIFIISNLKVYSYNYAIQYKNEGIDKYYFEILNDGFGFSLSDFFDDLRSGSLIFTYVSKYNFI INLEAHMLTYRGYKDSPKSLISRTDLIEIGFMYYFPILLLINGKNFGEIDLGIGVKNLLFGDWGGHLM QSIIHLILNQHRPIPSIKSYDSYNYRGFLSFALNYSYMNFLNLENYMDLSYFADYFIKNSIGITLKNENI GFDIKLYSQIQNQIKSLKTYSKTQEAETGIGINYQFYSKNFFITNNLNIKNFSTKENFLSVGGFGIILTPE EYKKISESNNEFNYISNNFYFGFDIMIPLKIRNSLFYKINENINHYFSISTNYYTNYNETNSFTNQLSSGI MYEFLPQKTFNPYLISGLFFAYNQNNKDIKSISRPIRIKNILQVGIENELGFLFKMLKYRNTEYIFKIYS KVNYIPIAYNLDEKKLEKHSINFNYLGIGIVVK t850.aa (SEQ ID NO:386) YSYNYAIQYKNEGIDKYYFEILNDGFGFSLSDFFDDLRSGSLIFYVSKYNFIINLEAHMLTYRGYKD SPKSLISRTDLIEIGFMYYFPILLLINGKNFGEIDLGIGVKNLLFGDWGGHLMQSIIHLILNQHRPIPSIK SYDSYNYRGFLSFALNYSYMNFLNLENYMDLSYFADYFIKNSIGITLKNENIGFDIKLYSQIQNQIKSL KTYSKTQEAETGIGINYQFYSKNFFITNNLNIKNFSTKENFLSVGGFGIIITPEEYKKISESNNEFNVISN NFYFGFDIMIPLKIRNSLFYKINENINHYFSISTNYYTNYNETNSFTNQLSSGIMYEFLPQKTFNPYLIS GLFFAYNQNNKDIKSISRPIRIKNILQVGIENELGFLFKMLKYRNTEYIFKIYSKVNYIPIAYNLDEKKL EKHSINFNYLGIGIVVK f850.nt (SEQ ID NO:387) ATGCGGTTTAAAAAAATATTTTTAATAATATTTATAATTTCTAATTTAAAAGTTTATTCTTATAA TTATGCAATCCAATATAAAAATGAAGGTATTGACAAATATTATTTTGAAATACTAAATGATGGA TTCGGATTTTCATTAAGCGATTTTTTTGATGACTTGAGAAGTGGTTCTCTTATTTTTACCTATGT TTCAAAATACAATTTTATAATAAATTTAGAAGCACACATGTTAACCTATAGGGGTTATAAAGAC TCTCCGAAATCTTTAATTAGTAGAACAGACTTAATTGAAATAGGCTTCATGTACTATTTTCCAAT TTTATTGCTAATTAATGGAAAAAATTTTGGAGAAATAGACTTGGGAATTGGAGTTAAAAACTTA TTATTTGGAGACTGGGGAGGGCATTTAATGCAAAGCATAATTCACCTCATTTAAATCAACACC GTCCAATTCCAAGTATAAAAAGCTACGACAGCTACAATTATAGAGGATTTTTAAGCTTTGCTCT AAATTACTCTTACATGAATTTTTTAAATTTAGAAAATTATATGGACTTATCTTATTTTGCAGATT ATTTTATTAAAAACAGTATTGGAATTACCTTAAAAAATGAAAATATTGGATTTGATATAAAACT TTATTCCCAAATTCAAAATCAAATCAAAAGCCTCAAAACATATTCAAAAACACAAGAAGCAGA AACAGGAATTGGAATAAATTATCAATTTTACTCTAAAAATTTTTTCATAACCAATAATTTAAAC ATTAAAAATTTTTCAACCAAAGAAAATTTCTTAAGCGTTGGGGGATTTGGAATAATCATTACAC CTGAAGAATACAAAAAAATATCAGAATCAAATAATGAATTTAATGTTATAAGTAATAATTTA CTTTGGATTTGATATTATGATCCCATTAAAAATAAGAAATTCATTATTTTATAAAATAAATGAA AACATCAACCATTACTTTTCAATATCAACAAATTATTACACTAATTATAATGAAACTAATAGCTT0 TACAAATCAATTATCATCAGGCATCATGTATGAATTTTTACCACAAAAAACATTCAATCCTTACC TAATTTCGGGATTATTTTTTGCCTATAATCAAAACAATAAAGATATCAAAAGCATCTCAAGACC AATAAGAATAAAAAACATTCTTCAAGTTGGAATTGAAAATGAATTAGGATTTTTGTTCAAAATG CTAAAATACCGCAACACTGAGTATATTTTCAAAATATATTCAAAAGTTAACTATATTCCTATAG CTTATAACTTAGATGAAAAAAAATTAGAAAAACATTCTATTAACTTTAATTATTTAGGAATTGG AATAGTCGTTAAATAA t850.nt (SEQ ID NO:388) TATTCTTATAATTATGCAATCCAATATAAAAATGAAGGTATTGACAAATATTATTTTGAAATAC TAAATGATGGATTCGGATTTTCATTAAGCGATTTTTTTGATGACTTGAGAAGTGGTTCTCTTATT TTTACCTATGTTTCAAAATACAATTTTATAATAAATTTAGAAGCACACATGTTAACCTATAGGG GTTATAAAGACTCTCCGAAATCTTTAATTAGTAGAACAGACTTAATTGAAATAGGCTTCATGTA CTATTTTCCAATTTTATTGCTAATTAATGGAAAAAATTTTGGAGAAATAGACTTGGGAATTGGA GTTAAAAACTTATTATTTGGAGACTGGGGAGGGCATTTAATGCAAAGCATAATTCACCTCATTT TAAATCAACACCGTCCAATTCCAAGTATAAAAAGCTACGACAGCTACAATTATAGAGGATTTTT AAGCTTTGCTCTAAATTACTCTTACATGAATTTTTTAAATTTAGAAAATTATATGGACTTATCTT ATTTTGCAGATTATTTTATTAAAAACAGTATTGGAATTACCTTAAAAAATGAAAATATTGGATT TGATATAAAACTTTATTCCCAAATTCAAAATCAAATCAAAAGCCTCAAAACATATTCAAAAACA CAAGAAGCAGAAACAGGAATTGGAATAAATTATCAATTTTACTCTAAAAATTTTTTCATAACCA ATAATTTAAACATTAAAAATTTTTCAACCAAAGAAAATTTCTTAAGCGTTGGGGGATTTGGAAT AATCATTACACCTGAAGAATACAAAAAAATATCAGAATCAAATAATGAATTTAATGTTATAAGT AATAATTTTTACTTTGGATTTGATATTATGATCCCATTAAAAATAAGAAATTCATTATTTTATAA AATAAATGAAAACATCAACCATTACTTTTCAATATCAACAAATTATTACACTAATTATAATGAA ACTAATAGCTTTACAAATCAATTATCATCAGGCATCATGTATGAATTTTTACCACAAAAAACAT TCAATCCTTACCTAATTTCGGGATTATTTTTTGCCTATAATCAAAACAATAAAGATATCAAAAGC ATCTCAAGACCAATAAGAATAAAAAACATTCTTCAAGTTGGAATTGAAAATGAATTAGGATTTT TGTTCAAAATGCTAAAATACCGCAACACTGAGTATATTTTCAAAATATATTCAAAAGTTAACTA TATTCCTATAGCTTATAACTTAGATGAAAAAAAATTAGAAAAACATTCTATTAACTTTAATTATT TAGGAATTGGAATAGTCGTTAAATAA f853.aa (SEQ ID NO:389) MKSFLFWVILGTVGISSFAQNTPVAIINLYKNEIITKTGFDSKVDIFKKTQGRDLTDAEKKQV LQVLIADVLFSQEASKQGIKISDDEVMQTIRTQFGLVNFTDEQIKQMIEKQGTNWGELLSSMKRSLSS QKLVLKQAQPKFSEIKTPSEKEIVEYYEANKTKFVNPDISRVSHIFFSTKDKKRSDVLDQAKNILSQIR SKKITFEEAVRKYSNDESSKAKNGDLGFLSRGDQNAQNLLGADFVKEVFNFNKGDISSPIASKEGFHI VKVTEKYAQRFLGLNDKVSPTADLIVKDAIRNNMINVQQQQIVVQVQQDMYGKLNKSANIQILDSS LK t853.aa (SEQ ID NO:390) QNTPVAIINLYKNEIITKTGFDSKVDIFKKTQGRDLTDAEKKQVLQVLIADVLFSQEASKQGI KISDDEVMQTIRTQFGLVNFTDEQIKQMIEKQGTNWGELLSSMKRSLSSQKLVLKQAQPKFSEIKTP SEKEIVEYYEANKTKFVNPDISRVSHIFFSTKDKKRSDVLDQAKNILSQIRSKKITFEEAVRKYSNDES SKAKNGDLGFLSRGDQNAQNLLGADFVKEVFNFNKGDISSPIASKEGFHIVKVTEKYAQRFLGLND KVSPTADLIVKDAIRNNMINVQQQQIVVQVQQDMYGKLNKSANIQILDSSLK f853.nt (SEQ ID NO:391) ATGAAGAGTTTTTTATTTTGGGTAATATTGGGAACTGTAGGGATTAGCTCTTTTGCTCAAAATA CTCCTGTTGCTATTATTAATTTATATAAGAATGAAATTATTACTAAAACTGGTTTTGATTCTAAG GTTGATATATTTAAAAAGACCCAAGGTAGAGACTTAACTGATGCTGAGAAAAAGCAAGTTCTG CAAGTTTTAATAGCAGATGTTCTTTTTAGTCAAGAGGCTTCAAAGCAAGGAATTAAAATCTCAG ATGATGAGGTTATGCAAACAATTAGAACTCAATTTGGGCTTGTGAATTTTACTGATGAACAAAT CAAGCAAATGATAGAAAAACAAGGTACAAATTGGGGCGAGCTTTTGTCTTCAATGAAAAGATC TCTGTCTTCTCAAAAGCTTGTTTTAAAGCAAGCTCAGCCTAAGTTTTCTGAAATTAAAACTCCTA GTGAGAAAGAAATTGTTGAGTATTATGAGGCTAATAAAACTAAGTTTGTAAATCCCGATATTTC AAGAGTTAGTCATATCTTTTTTTCTACTAAAGATAAAAAAAGATCAGATGTTTTAGATCAAGCA AAAAATATTTTAAGCCAAATAAGATCAAAAAAAATTACTTTTGAAGAAGCTGTAAGAAAATATT CAAATGACGAATCTTCTAAGGCTAAAAATGGTGATCTTGGGTTTTTATCAAGAGGTGATCAAAA TGCTCAAAATCTTCTTGGAGCCGATTTTGTGAAAGAGGTTTTTAATTTTAATAAGGGTGATATA TCTTCGCCTATTGCTTCAAAGGAAGGGTTTCATATTGTTAAAGTTACAGAAAAATATGCTCAGA GATTTTTAGGTTTGAATGATAAAGTGTCTCCTACTGCAGATTTGATTGTCAAAGATGCAATAAG AAATAACATGATTAATGTTCAACAACAGCAAATTGTTGTTCAAGTACAGCAAGATATGTATGGT AAGCTTAACAAGTCTGCAAATATACAAATCTTGGATTCTAGTCTAAAATAA t853.nt (SEQ ID NO:392) CAAAATACTCCTGTTGCTATTATTAATTTATATAAGAATGAAATTATTACTAAAACTGG TTTTGATTCTAAGGTTGATATATTTAAAAAGACCCAAGGTAGAGACTTAACTGATGCTGAGAAA AAGCAAGTTCTGCAAGTTTTAATAGCAGATGTTCTTTTTAGTCAAGAGGCTTCAAAGCAAGGAA TTAAAATCTCAGATGATGAGGTTATGCAAACAATTAGAACTCAATTTGGGCTTGTGAATTTTAC TGATGAACAAATCAAGCAAATGATAGAAAAACAAGGTACAAATTGGGGCGAGCTTTTGTCTTC AATGAAAAGATCTCTGTCTTCTCAAAAGCTTGTTTTAAAGCAAGCTCAGCCTAAGTTTTCTGAA ATTAAAACTCCTAGTGAGAAAGAAATTGTTGAGTATTATGAGGCTAATAAAACTAAGTTTGTAA ATCCCGATATTTCAAGAGTTAGTCATATCTTTTTTTCTACTAAAGATAAAAAAAGATCAGATGTT TTAGATCAAGCAAAAAATATTTTAAGCCAAATAAGATCAAAAAAAATTACTTTTGAAGAAGCTG TAAGAAAATATTCAAATGACGAATCTTCTAAGGCTAAAAATGGTGATCTTGGGTTTTTATCAAG AGGTGATCAAAATGCTCAAAATCTTCTTGGAGCCGATTTTGTGAAAGAGGTTTTTAATTTTAAT AAGGGTGATATATCTTCGCCTATTGCTTCAAAGGAAGGGTTTCATATTGTTAAAGTTACAGAAA AATATGCTCAGAGATTTTTAGGTTTGAATGATAAAGTGTCTCCTACTGCAGATTTGATTGTCAA AGATGCAATAAGAAATAACATGATTAATGTTCAACAACAGCAAATTGTTGTTCAAGTACAGCAA GATATGTATGGTAAGCTTAACAAGTCTGCAAATATACAAATCTTGGATTCTAGTCTAAAATAA f859.aa (SEQ ID NO:393) MKLPKLYKLILLFLFTTRLFSVKDEKSDNKLELFSNVETKIKKNSKNYDSNSNSKKIKKESILKRDTN SEKNINSNIYIQKSKKINYPNRNLGNNINQKTANDVNFTKTSYVKVYPNYKDDNFQEIKNANKFPAK TEKTHMLIGPILKDNLGIIIKMLKTKGYTLIEYIEDNN t859.aa (SEQ ID NO:394) VKDEKSDNKLELFSNVETKIKKNSKNYDSNSNSKKIKKESILKRDTNSEKNINSNIYIQKSKKINYPN RNLGNNINQKTA f859.nt (SEQ ID NO:395) ATGAAATTACCAAAACTTTACAAATTAATACTACTCTTTCTTTTTACAACAAGATTGTTTTCAGT AAAAGATGAAAAATCAGACAATAAATTGGAATTATTTTCAAACGTAGAAACAAAAATCAAAAA AAATTCTAAAAATTACGACTCAAATTCAAACAGCAAAAAGATCAAAAAAGAATCAATTTTAAA AAGAGATACAAACAGCGAAAAAAATATAAATTCCAATATATACATACAAAAATCAAAAAAAAT TAATTACCCCAACAGAAATTTAGGCAATAATATCAATCAAAAAACTGCAAATGATGTAAATTTT ACAAAAACTAGTTATGTTAAAGTTTATCCCAACTATAAAGACGATAACTTTCAAGAAATTAAAA ATGCTAATAAATTTCCAGCTAAAACCGAAAAAACTCACATGCTAATCGGCCCAATATTAAAAGA TAATCTAGGAATAATAATTAAAATGCTAAAAACAAAGGGATACACTTTAATAGAATACATAGA GGACAATAATTAA t859.nt (SEQ ID NO:396) GTAAAAGATGAAAAATCAGACAATAAATTGGAATTATTTTCAAACGTAGAAACAAAAATCAAA AAAAATTCTAAAAATTACGACTCAAATTCAAACAGCAAAAAGATCAAAAAAGAATCAATTTTA AAAAGAGATACAAACAGCGAAAAAAATATAAATTCCAATATATACATACAAAAATCAAAAAAA ATTAATTACCCCAACAGAAATTTAGGCAATAATATCAATCAAAAAACTGCAAATGATGTAAATT TTACAAAAACTAGTTATGTTAAAGTTTATCCCAACTATAAAGACGATAACTTTCAAGAAATTAA AAATGCTAATAAATTTCCAGCTAAAACCGAAAAAACTCACATGCTAATCGGCCCAATATTAAAA GATAATCTAGGAATAATAATTAAAATGCTAAAAACAAAGGGATACACTTTAATAGAATACATA GAGGACAATAATTAA f861.aa (SEQ ID NO:397) MKNFKEVIIIFDSGIGGLSYFKYIKSRIGGCQYVYVADNKNFPYGEKSPEYLLEAVLFLIEKLKKIYNI GALVLACNTISVSVYNKLNFVFPVVYTLPDVSSVSDLVLKRVLLIATNTTLESKFVKDQVNIHNDLIV KAAGELVNFVEYGENYKKYALRCLEALKFEVVNTGREIVFLGCTHYLHLKVMIEDFLKIPVYENRE LVVKNLIRSMNFSEHKGNYYKNDFDFVDDEFYLTENKNLTFYQNFCKKYNLRFKGMIV t861.aa (SEQ ID NO:398) RIGGCQYVYVADNKNFPYGEKSPEYLLEAVLFLIEKLKKIYNIGALVLACNTISVSVYNKLN FVFPVVYTLPDVSSVSDLVLKRVLLIATNTTLESKFVKDQVNIHNDLIVKAAAGELVNFVEYGENYKK YALRCLEALKFEVVNTGREIVFLGCTHYLHLKVMIEDFLKIPVYENRELVVKNLIRSMNFSEHKGNY YKNDFDFVDDEFYLTENKNLTFYQNFCKKYNLRFKGMIV f861.nt (SEQ ID NO:399) ATGAAAAATTTCAAAGAAGTAATAATTATTTTTGATTCAGGAATAGGAGGGCTTTCTTATTTTA AATATATTAAAAGTAGAATAGGGGGATGCCAATATGTTTATGTTGCCGATAATAAAAATTTCCC TTATGGAGAAAAAAGTCCTGAATATCTTCTAGAAGCAGTTTTGTTTTTGATTGAGAAGCTTAAA AAAATCTATAATATTGGTGCATTAGTTTTGGCTTGTAATACAATTTCTGTTAGTGTATACAATAA ATTAAATTTTGTTTTTCCAGTAGTCTATACTTTGCCAGATGTAAGTTCAGTTTCAGATCTTGTTT TAAAAAGAGTTCTTTTGATTGCAACAAATACTACTCTTGAAAGCAAATTTGTTAAGGATCAAGT AAATATACATAATGATTTGATTGTAAAAGCTGCTGGAGAGCTTGTTAATTTTGTTGAATATGGA GAGAATTACAAAAAATATGCTCTTAGATGTTTAGAAGCTTTAAAATTTGAAGTTGTAAATACTG GTAGAGAAATTGTTTTTCTTGGATGCACGCATTATTTGCATCTTAAGGTAATGATAGAAGATTT TTTAAAAATTCCTGTTTATGAGAATCGTGAATTAGTGGTAAAAAATCTTATTAGATCAATGAAT TTTTCTGAACACAAAGGTAATTATTATAAGAATGATTTTGATT TTTAGATGATGAGTTTTATTT GACCGAAAATAAAAATTTGACTTTTTATCAAAATTTTTGCAAAAAATATAATCTTCGCTTTAAG GGAATGATAGTTTGA t861.nt (SEQ ID NO:400) AGAATAGGGGGATGCCAATATGTTTATGTTGCCGATAATAAAAATTTCCCTTATGGAGAAAAAA GTCCTGAATATCTTCTAGAAGCAGTTTTGTTTTTGATTGAGAAGCTTAAAAAAATCTATAATATT GGTGCATTAGTTTTGGCTTGTAATACAATTTCTGTTAGTGTATACAATAAATTAAATTTTGTTTTT TCCAGTAGTCTATACTTTGCCAGATGTAAGTTCAGTTTCAGATCTTGTTTTAAAAAGAGTTCTTT TGATTGCAACAAATACTACTCTTGAAAGCAAATTTGTTAAGGATCAAGTAAATATACATAATGA TTTGATTGTAAAAGCTGCTGGAGAGCTTGTTAATTTTGTTGAATATGGAGAGAATTACAAAAAA TATGCTCTTAGATGTTTAGAAGCTTTAAAATTTGAAGTTGTAAATACTGGTAGAGAAATTGTTT TTCTTGGATGCACGCATTATTTGCATCTTAAGGTAATGATAGAAGATTTTTTAAAAATTCCTGTT TATGAGAATCGTGAATTAGTGGTAAAAAATCTTATTAGATCAATGAATTTTTCTGAACACAAAG GTAATTATTATAAGAATGATTTTGATTTTGTAGATGATGAGTTTTATTTGACCGAAAATAAAAA TTTGACTTTTTATCAAAATTTTTGCAAAAAATATAATCTTCGCTTTAAGGGAATGATAGTTTGA f363.aa (SEQ ID NO:401) MIRLKVLILCLFGIFVLNGFADTNFEFNFGGGVAFPVSPFSSFYNEALEINAKLKQNLPSDLSPIEKEEI VQNFSDLANIAKAGIRYGTYAQFGAKFDDFVSIGFELLFNINLLKAIKRSDGTANENFSFIMAITPRFY TKLDFFVLALAFFTGPKINIATSSADSVLAELGTMGWDIGARLSFSFLILEGYYVWNIKNPKFSDFKF GIGFEFGIV t363.aa (SEQ ID NO:402) DTNFEFNFGGGVAFPVSPFSSFYNEALEINAKLKQNLPSDLSPIEKEEIVQNFSDLANIAKAGIRYGTY AQFGAKFDDFVSIGFELLFNINLLKAIKRSDGTANENFSFIMAITPRFYTKLDFFVLALAFFTGPKINIA TSSADSVLAELGTMGWDIGARLSFSFLILEGYYVWNIKNPKFSDFKFGIGFEFGIV f363.nt (SEQ ID NO:403) ATGATTAGGCTTAAACTTTTAATTTTGTGTTTATTTGGGATTTTTGTGTTAAATGGTTTTGCAGA TACTAATTTTGAATTCAATTTTGGTGGTGGGGTTGCTTTTCCTGTTAGTCCCTTTTCAAGCTTTT ACAATGAGGCTTTAGAGATTAATGCAAAGCTTAAGCAAAATTTGCCTTCAGATTTATCCCCAAT AGAAAAAGAAGAGATAGTCCAAAATTTTTCCGATTTAGCCAATATTGCTAAAGCTGGAATAAG ATATGGAACTTACGCTCAATTTGGCGCTAAATTTGATGATTTTGTTTCTATTGGATTTGAGCTTT TGTTTAACATTAATCTTCTTAAAGCAATAAAGCGTTCGGATGGAACTGCAAATGAAAATTTCTC GTTTATTATGGCAATAACACCAAGATTTTATACAAAATTAGATTTTTTTGTTTTAGCTTTAGCGT TTTTCACAGGTCCTAAGATCAATATAGCGACTTCTTCTGCGGATTCTGTTTTAGCAGAACTGGG AACAATGGGCTGGGATATTGGTGCTAGACTTTCATTTTCTTTTTTAATTCTTGAAGGGTACTATG TTTGGAATATTAAAAACCCTAAATTTTCTGATTTCAAGTTTGGAATAGGTTTTGAATTTG GAATTGTGTAG t363.nt (SEQ ID NO:404) GATACTAATTTTGAATTCAATTTTGGTGGTGGGGTTGCTTTTCCTGTTAGTCCCTTTTCAAGCTT TTACAATGAGGCTTTAGAGATTAATGCAAAGCTTAAGCAAAATTTGCCTTCAGATTTATCCCCA ATAGAAAAAGAAGAGATAGTCCAAAATTTTTCCGATTTAGCCAATATTGCTAAAGCTGGAATAA GATATGGAACTTACGCTCAATTTGGCGCTAAATTTGATGATTTTGTTTCTATTGGATTTGAGCTT TTGTTTAACATTAATCTTCTTAAAGCAATAAAGCGTTCGGATGGAACTGCAAATGAAAATTTCT CGTTTATTATGGCAATAACACCAAGATTTTATACAAAATTAGATTTTTTTGTTTTAGCTTTAGCG TTTTTCACAGGTCCTAAGATCAATATAGCGACTTCTTCTGCGGATTCTGTTTTAGCAGAACTGGG AACAATGGGCTGGGATATTGGTGCTAGACTTTCATTTTCTTTTTTAATTCTTGAAGGGTACTATG TTTGGAATATTAAAAACCCTAAATTTTCTGATTTCAAGTTTGGAATAGGTTTTGAATTTGGAATT GTGTAG f368.aa (SEQ ID NO:405) MIDLTQEKQEILIKNKFLAKVFGLMSIGLLISAVFAYATSENQTIKAIIFSNSMSFMAMILIQFGLVYAI SGALNKISSNTATALFLLYSALTGVTLSSIFMIYTQGSIVFTFGITAGTFLGMSVYGYTTTTDLTKMGS YLIMGLWGIIIASLVNMFFRSSGLNFLISILGVVIFTGLTAYDVQNISKMDKMLQDDTEIKNRMAVVA SLKLYLDFINLFLYLLRFLGQRRND t368.aa (SEQ ID NO:406) TSENQTIKAIIFSNSMSFMAMILIQFGLVYAISGALNKISSNTATALFLLYSALTGVTLSSIFMIYTQGSI VFTFGITAGTFLGMSVYGYTTTTDLTKMGSYLIMGLWGIIIASLVNMFFRSSGLNFLISILGVVIFTGL TAYDVQNISKMDKMLQDDTEIKNRMAVVASLKLYLDFINLFLYLLRFLGQRRND f368.nt (SEQ ID NO:407) ATGATCGATTTAACACAAGAAAAACAAGAAATACTAATAAAAAACAAGTTTTTAGCCAAAGTTT TCGGGCTTATGTCAATTGGACTTTTAATCTCAGCAGTATTTGCATATGCAACCTCAGAAAATCA AACAATCAAAGCAATAATATTCTCAAATTCAATGTCATTTATGGCTATGATACTTATACAATTT GGACTTGTATATGCAATAAGTGGTGCTCTTAATAAAATATCAAGCAATACTGCAACAGCTCTTT TCTTGCTCTACTCAGCACTAACAGGAGTAACATTATCTTCTATATTTATGATTTACACACAAGGA TCAATAGTATTCACATTCGGAATTACTGCTGGAACATTTCTTGGAATGTCTGTTTATGGATACAC TACAACAACAGATCTAACAAAAATGGGAAGCTATTTAATAATGGGCTTATGGGGAATCATTATT GCATCTCTTGTTAATATGTTTTTTAGAAGCTCAGGTCTTAATTTCCTTATATCTATTTTGGGCGT AGTTATATTTACAGGCTTAACAGCTTATGATGTTCAAAATATTTCTAAAATGGACAAAATGCTA CAAGACGACACTGAAATAAAAAACAGAATGGCGGTTGTAGCCTCACTTAAACTTTATTTAGATT TTATAAATTTATTCTTATATCTTCTAAGATTTTTGGGCCAAAGAAGAAACGATTAA t368.nt (SEQ ID NO:408) ACCTCAGAAAATCAAACAATCAAAGCAATAATATTCTCAAATTCAATGTCATTTATGGCTATGA TACTTATACAATTTGGACTTGTATATGCAATAAGTGGTGCTCTTAATAAAATATCAAGCAATAC TGCAACAGCTCTTTTCTTGCTCTACTCAGCACTAACAGGAGTAACATTATCTTCTATATTTATGA TTTACACACAAGGATCAATAGTATTCACATTCGGAATTACTGCTGGAACATTTCTTGGAATGTC TGTTTATGGATACACTACAACAACAGATCTAACAAAAATGGGAAGCTATTTAATAATGGGCTTA TGGGGAATCATTATTGCATCTCTTGTTAATATGTTTTTTAGAAGCTCAGGTCTTAATTTCCTTAT ATCTATTTTGGGCGTAGTTATATTTACAGGCTTAACAGCTTATGATGTTCAAAATATTTCTAAAA TGGACAAAATGCTACAAGACGACACTGAAATAAAAAACAGAATGGCGGTTGTAGCCTCACTTA AACTTTATTTAGATTTTATAAATTTATTCTTATATCTTCTAAGATTTTTGGGCCAAAGAAGAAAC GATTAA f371.aa (SEQ ID NO:409) MKFFFLLQIALILLSNSSLLFGQSPPKEKEDSLLLYKEGKFKEAILNTLEEIRLNPSNLDARTILIWSLIA IGEYKRAEKEAIIGLGIKKHDIRIIQALGEAYFPQKNYDNALKYFQEYISLDSKGARIIKVYNLIADSFY ELKRYNEADFAYEHALRFSPNNQNLLIKLARSRINAKNKILAEEALIKILTISPNNLEAKNLLEELKKS NNKP t371.aa (SEQ ID NO:410) EDSLLLYKEGKFKEAILNTLEEIRLNPSNLDARTILIWSLIAIGEYKRAEKEAIIGLGIKKHDIRIIQALG EAYFFQKNYDNALKYFQEYISLDSKGARIIKVYNLIADSFYELKRYNEADFAYEHALRFSPNNQNLLI KLARSRINAKNKILAEEALIKILTISPNNLEAKNLLEELKKSNNKP f371.nt (SEQ ID NO:411) ATGAAATTTTTTTTTCTATTACAAATAGCTTTAATTCTACTATCCAATTCAAGCTTGTTATTTGG ACAATCACCGCCTAAAGAAAAAGAAGACTCTCTTCTTCTATATAAAGAAGGAAAATTTAAAGA AGCTATTTTAAACACGTTAGAAGAAATTCGACTAAATCCTAGTAACTTAGATGCTAGGACAATA TTGATATGGAGCTTAATAGCCATAGGAGAATACAAGAGAGCTGAAAAAGAGGCGATTATAGGA CTTGGCATTAAAAAACATGACATAAGAATTATTCAAGCACTAGGAGAAGCTTATTTCTTTCAAA AAAATTATGACAATGCATTAAAATACTTTCAAGAATACATTAGCCTTGATTCTAAAGGAGCAAG AATAATAAAAGTTTATAATTTAATTGCAGATTCTTTTTATGAGCTAAAAAGATATAATGAAGCC GATTTTGCATACGAACATGCATTACGTTTTTCTCCTAATAACCAAAATCTATTAATAAAATTAGC AAGATCAAGAATAAATGCAAAAAATAAAATATTAGCAGAAGAAGCACTAATTAAAATTCTTAC AATCTCTCCTAATAATCTAGAGGCAAAAAATTTACTAGAAGAATTAAAAAAAAGCAACAACAA ACCTTGA t371.nt (SEQ ID NO:412) GAAGACTCTCTTCTTCTATATAAAGAAGGAAAATTTAAAGAAGCTATTTTAAACACGTTAGAAG AAATTCGACTAAATCCTAGTAACTTAGATGCTAGGACAATATTGATATGGAGCTTAATAGCCAT AGGAGAATACAAGAGAGCTGAAAAAGAGGCGATTATAGGACTTGGCATTAAAAAACATGACAT AAGAATTATTCAAGCACTAGGAGAAGCTTATTTCTTTCAAAAAAATTATGACAATGCATTAAAA TACTTTCAAGAATACATTAGCCTTGATTCTAAAGGAGCAAGAATAATAAAAGTTTATAATTTAA TTGCAGATTCTTTTTATGAGCTAAAAAGATATAATGAAGCCGATTTTGCATACGAACATGCATT ACGTTTTTCTCCTAATAACCAAAATCTATTAATAAAATTAGCAAGATCAAGAATAAATGCAAAA AATAAAATATTAGCAGAAGAAGCACTAATTAAAATTCTTACAATCTCTCCTAATAATCTAGAGG CAAAAAATTTACTAGAAGAATTAAAAAAAAGCAACAACAAACCTTGA f502.aa (SEQ ID NO:413) MKKANFLSTNFLILLLVCFVNVNLFSKDIFKFKLVDQFFPFYYKNNKGEYEGLIFSILDKWAKDNNA DIMVEHIDNLNESEIEDEAIYLGLTYNVKLNDFFYFKSELARSISILFFKNSNKKYKNTHSTFLSNFNIG VIKNTIYEDILRLKNVNTIFLADNSQELVLALKNDKVDYIYGDCKTLHYIANNFLSEDLVIFTGDVFY SIKNRVAISRNAPEIVKNLNLDLFSYLMKMPEELVFSFLDSNAKGSFVDVGLYNDYPPLSFINSQGKL SGILVDLWNLLSRQHIFKPIFKGFSKEDIKKSLDGKSVGIFGGIISNDSVLENVNYVVSKPIYPLNFKFY SKDLSNDAGPINSQFIDFNFNNIQLNKNKDIVNNFIDIVNNSYGFIENSITTKYLLKLNGYNGRLKSYD SIFNKNRFLVIALDNRIYKVIKYILNSIFDDISFESLLQIDKNWLDKEEINSSRINSYKIMNKVKFNIEEK IWLSKNNKLNLAVKNWYPIDYVEANNYKGINQFLLDKIRMFSGLRFNIIKVHSSLDLKKLIKSGKID MLNTNATDSNLDNVFNIKLNSRIPLYIFSNKKRVLPSRSLEKFAILDFLYSKNLASNIKSKLILVSSFNE ALLLLYKGKVDGIISDEYTAAAVFEELNIDDVEKIPTFRDLAFDLSLAIYNQDYILKEIIQKVVMRSNV DSQMYLNDWKFDIYYKSRSIRFKNFKFLVITFIIFYFTFLGFVIIFMFRLSFEQKRRYSFVMNEKKIAE AANAAKTIFIANVSHDIRTPINGIMAATELLDTTILTDVQKDYVRMINYSSDSLLSLIDDILYLSKIDV NELYVESQEIDLESEMEMVLKAFQSQCAKKNIDLFSYSKSIFNNYIKGDIVKIKQVLINLIGNAFKFTD DGVIVLNYEEVCRTRTDGNRVLVTVEFKVIDTGKGIEKENFSKIFEIFKQEDDSSSRVHEGAGLGLSIS RELIRLMGGLGIAVDSKVGEGTTFSFMLPFLLGSELKSKKLSINRFQSVNGDNKVLNVLLSQKSIKIFE HCSILLGCSSNVRYVASFEDAYKVFKKYPSYNFVINVNNDAAQEGIRLANNIERLNSDVQIIFLFYYL DNKALKNLKYGYVKKPLMGLGICSILYKKEFNPEMDFEDLVPIDSALRIKEPINVLIAEDNQVNQKV LKDILVVIGINENFIDVVDDGVKALKSLKDKKYTISFIDIRMPRYDGFSVAKEIRKFEKAKNLKPCVL VAVTAHALQEYKDKCLASGMNDYISKPIHISSIKTILKKYLQFEVDDIGENENLNQLVKFPNLDVNR ALKELNLSYVSYSELCRGLVDFISTNIIDLEKAFDEEDLSLIKDISHSISGALSNMRSELYKDFQKIETSK DSISELKKMYSFVKDDLFQLISDIKENILFESEIVSENKLYFKNNDQFLNLLNKLLIGIKTRKPREYKEI LESINKYVLDDNIQVLFSDLRRNLRLYRFAESSKILEEIIEMLNNKRY t502.aa (SEQ ID NO:414) CFVNVNLFSKDIFKFKLVDQFFPFYYKNNKGEYEGLIFSILDKWAKDNNADIMVEHIDNLNESEIEDE AIYLGLTYNVKLNDFFYFKSELARSISILFFKNSNKKYKNTHSTFLSNFNIGVIKNNTIYEDILRLKNVN TIFLADNSQELVLALKNDKVDYIYGDCKTLHYIANNFLSEDLVIFTGDVFYSIKNRVAISRNAPEIVK NLNLDLFSYLMKMPEELVFSFLDSNAKGSFVDVGLYNDYPPLSFINSQGKLSGILVDLWNLLSRQHI FKPIFKGFSKEDIKKSLDGKSVGIFGGIISNDSVLENVNYVVSKPIYPLNFKFYSKDLSNDAGPINSQFI DFNFNIQLNKNKDIVNNFIDIVNNSYGFIENSITTKYLLKLNGYNGRLKSYDSIFNKNRFLVLAIDNR IYKVIKYILNSIFDDISFESLLQIDKNWLDKEEINSSRINSYKIMNKVKFNIEEKIWLSKNNKLNLAVKN WYPIDYVEANNYKGINQFLLDKIRMFSGLRFNIIKVHSSLDLKKLIKSGKIDMLNTNATDSNLDNVF NIKLNSRIPLYIFSNKKRVLPSRSLEKFAILDFLYSKNLASNIKSKLILVSSFNEALLLLYKGKVDGIISD EYTAAAVFEELNIDDVEKIPTFRDLAFDLSLAIYNQDYILKEIIQKVVMRSNVDSQMYLNDWKFDIY YKSRSIRFKNFKFLVITFIIFYFTFLGFVIIFMFRLSFEQKRRYSFVMNEKKIAEAANAAKTIFIANVSHD IRTPINGIMAATELLDTTILTDVQKDYVRMINYSSDSLISLTDDILYLSKIDVNELYVESQEIDLESEME MVLKAFQSQCAKKNIDLFSYSKSIFNNYIKGDIVKIKQVLINLIGNAFK DDGVIVLNYEEVCRTRT DGNRVLVTVEFKVIDTGKGIEKENFSKIFEIFKQEDDSSSRVHEGAGLGLSISRELIRLMGGLGIAVDS KVGEGTTFSFMLPFLLGSELKSKKLSINRFQSVNGDNKVLNVLLSQKSIKIFEHCSILLGCSSNVRYVA SFEDAYKVFKKYPSYNFVYINVNNDNIQEGIRLANNIERLNSDVQIIFLFYYLDNKALKNLKYGYVK KPLMGLGICSILYKKEFNPEMDFEDLVPIDSALRIKEPINVLIAEDNQVNQKVLKDILVVIGINENFTD VVDDGVKALKSLKDKKYTISFIDIRMPRYDGFSVAKEIRKFEKAKNLKPCVLVAVTAHALQEYKDK CLASGMNDYISKPIHISSIKTILKKYLQFEVDDIGENENLNQLVKFPNLDYNRALKELNLSYVSYSEL CRGLVDFISINIIDLEKAFDEEDLSLIKDISHSISGALSNMRSELYKDFQKIETSKDSISELKKMYSFVK DDLFQLISDIKENILFESEIVSENKLYFKNNDQFLNLLNKLLIGIKTRKPREYKEILESINKYVLDDNIQ VLFSDLRRNLRLYRFAESSKILEEIIEMLNNKRY f502.nt (SEQ ID NO:415) ATGAAAAAAGCAAACTTTTTAAGTACTAATTTTTTAATTTTACTTTTGGTTTGCTTTGTCAACGT CAATTTATTTTCTAAGGATATTTTCAAGTTTAAGCTTGTAGATCAATTTTTTCCTTTTTACTACA AGAATAATAAAGGAGAATATGAAGGACTTATTTTTTCTATTTTAGATAAATGGGCAAAAGATAA TAATGCTGATATTATGGTTGAGCATATTGATAATTTAAATGAAAGTGAAATTGAAGACGAAGCA ATATATTTAGGATTAACTTATAATGTAAAATTAAATGATTTTTTTTATTTTAAAAGTGAGCTTGC TAGGAGTATTTCAATTTTATTTTTTAAAAACTCTAATAAAAAATATAAAAATACCCATTCAACAT TTTTATCCAATTTTAATATAGGAGTTATTAAAAATACAATATATGAAGATATCTTAAGGTTAAA AAACGTTAACACCATTTTTTTGGCTGATAATTCTCAAGAGTTAGTATTGGCCTTAAAAAACGAT AAAGTTGATTATATATATGGTGATTGCAAGACTTTACATTATATTGCAAATAACTTTTTAAGTG AAGATCTTGTGATTTTTTACCGGGGATGTTTTTATAGTATCAAAAATAGAGTGGCTATTAGTAG AAATGCTCCTGAGATAGTAAAGAATTTGAATTTAGATTTGTTTTCATATTTAATGAAAATGCCT GAGGAACTTGTTTTTTCTTTTTTAGATAGCAATGCTAAGGGAAGTTTTGTTGATGTTGGTTTATA TAATGATTATCCTCCTTTAAGTTTTATTAATTCACAGGGAAAATTGTCTGGCATTTTAGTGGATT TGTGGAATCTTCTCTCAAGACAACATATCTTTAAACCTATTTTTAAGGGATTTTCCAAAGAGGA TATTAAGAAATCATTAGATGGAAAATCAGTAGGTATTTTTGGAGGAATTATTAGCAATGATAGT GTGTTGGAAAATGTTAATTATGTAGTAAGTAAGCCAATATATCCTCTTAATTTTAAATTTTATTC TAAAGACCTAAGCAATGATGCTGGTCCAATAAATTCTCACTTTATTGATTTTAATTTTAATAATA TTCAATTAAATAAGAATAAAGATATTGTTAATAACTTTATAGATATTGTTAATAATTCATATGG GTTTATAGAAAATTCAATAACAACAAAATATTTGTTAAAATTAAATGGATATAACGGTAGATTA AAATCTTACGATTCGATTTTTAATAAAAATAGGTTTTTAGTATTAGCCATTGATAATAGGATTTA TAAGGTTATTAAATATATTCTCAATTCTATATTTGATGATATTTCATTTGAATCTTTGCTTCAAA TAGATAAAAATTGGTTGGATAAAGAAGAGATTAATAGTTCTAGAATAAATAGTTATAAAATTAT GAATAAGGTTAAATTTAATATAGAAGAAAAAATTTGGTTATCAAAAAATAATAAATTAAATCTT GCTGTTAAAAATTGGTATCCAATAGATTATGTTGAGGCAAATAATTATAAAGGAATAAATCAAT TTTTGCTTGATAAGATTAGAATGTTTTCAGGTTTGAGATTTAACATAATTAAAGTACACAGCAG TTTAGATCTTAAAAAATTAATCAAATCTGGAAAAATCGATATGCTAAATACTAATGCAACCGAT TCAAATTTAGATAATGTTTTCAACATAAAATTAAATTCTCGAATTCCACTTTATATTTTTTCAAA TAAGAAAAGGGTGCTTCCATCTAGATCTTTAGAAAAGTTTGCTATACTTGATTTTTTATATAGTA AAAATTTGGCTTCTAATATTAAATCAAAGCTTATTCTGGTAAGCAGTTTTAATGAAGCGTTGCTT CTTCTTTATAAGGGAAAGGTAGATGGGATTATTAGCGATGAGTATACAGCTGCTGCTGTTTTTG AGGAATTAAATATTGATGATGTTGAAAAAATTCCTACTTTTAGAGATTTGGCTTTTGATTTGAG TCTTGCTATTTATAATCAAGATTATATCTTGAAAGAAATTATTCAAAAAGTTGTTATGCGTTCAA ATGTTGACAGTCAGATGTATTTAAATGATTGGAAATTTGATATTTATTATAAATCCAGAAGTAT CAGGTTTAAAAATTTCAAATTTTTAGTGATAACATTCATTATATTTTATTTTACTTTTTTAGGAT TTGTAATTATATTTATGTTCAGATTATCATTTGAGCAGAAAAGAAGATATTCTTTTGTGATGAAT GAAAAAAAGATTGCGGAAGCCGCTAATGCTGCTAAAACCATTTTTATAGCCAATGTCAGTCATG ATATTCGTACCCCTATTAACGGAATAATGGCGGCTACTGAGCTTTTGGATACAACTATTCTTAC AGATGTTCAAAAAGATTATGTTAGGATGATAAATTATTCATCTGATTCTTTGCTTTCTTTAATTG ATGATATATTGTATTTGTCTAAAATAGATGTCAATGAATTATATGTTGAGAGTCAAGAGATTGA TTTAGAGAGTGAAATGGAAATGGTTTTAAAAGCTTTTCAATCTCAATGTGCAAAGAAAAATATT GATTTATTCTCTTATTCTAAATCTATTTTTAATAATTATATAAAGGGTGATATTGTAAAAATTAA ACAAGTTTTAATTAATTTAATAGGAAATGCTTTTAAGTTTACAGATGATGGTGTTATTGTTTTAA ATTATGAAGAAGTATGTAGAACAAGAACTGATGGTAATAGGGTTTTGGTTACAGTTGAATTTAA GGTAATAGATACAGGCAAAGGGATTGAAAAAGAAAATTTTTCTAAGATATTTGAAATATTTAA ACAAGAGGATGATTCTTCTTCAAGGGTTCATGAAGGTGCAGGATTGGGATTGTCAATATCTAGA GAGCTTATAAGACTAATGGGTGGTCTTGGTATTGCTGTTGATAGCAAGGTGGGAGAGGGTACA ACTTTTTCATTTATGTTGCCCTTTTTATTGGGTAGTGAGCTTAAAAGTAAAAAATTGTCAATCAA TAGATTTCAATCAGTAAATGGTGACAATAAAGTATTAAATGTGCTTTTAAGTCAAAAATCTATT AAAATTTTTGAGCACTGTTCGATTTTATTGGGATGCTCTTCTAATGTGCGCTATGTAGCGTCTTT TGAGGATGCTTATAAAGTCTTCAAGAAATACCCTTCTTATAATTTTGTTTATATAAATGTAAATA ACGATAATATTCAAGAGGGTATTCGACTTGCCAATAATATTGAAAGACTAAATTCTGATGTACA AATTATTTTTTTATTTTATTATTTAGATAATAAAGCTCTAAAAAATTTAAAATATGGTTATGTTA AAAAGCCTTTAATGGGGCTTGGTATATGCTCTATTCTTTATAAAAAAGAGTTTAACCCAGAAAT GGATTTTGAGGATTTGGTTCCAATAGATAGTGCTTTAAGGATAAAAGAGCCCATTAATGTTTTA ATAGCTGAAGATAATCAGGTAAATCAAAAAGTGTTGAAAGATATTCTTGTTGTTATAGGCATTA ATGAAAATTTTATTGATGTTGTAGATGATGGAGTAAAGGCTTTAAAATCTTTAAAAGATAAAAA ATATACTATCTTTTATTGATATACGAATGCCAAGATATGATGGATTTTCGGTGGCTAAGGAA ATTAGAAAATTTGAAAAGGCAAAGAATTTAAAGCCTTGTGTTTTGGTTGCTGTAACAGCGCATG CTTTGCAAGAGTATAAAGACAAGTGTCTTGCAAGTGGTATGAATGATTATATCTCAAAACCAAT ACACATAAGTTCAATTAAAACTATATTAAAAAAATACTTACAGTTTGAAGTTGATGATATTGGG GAGAATGAAAATTTGAATCAACTTGTTAAGTTTCCTAATTTAGATGTTAATAGGGCTTTAAAAG AATTAAATCTTTCATATGTATCATATTCTGAATTATGTAGAGGGCTTGTTGATTTTATCTCTATT AATATTATTGATTTGGAAAAGCTTTTGATGAGGAAGATTTGTCTTTAATTAAGGATATATCTC ATTCAATATCTGGAGCTCTTTCTAATATGCGTAGCGAATTGTATAAAGATTTTCAAAAAATTGA AACAAGTAAAGATTCAATTTCTGAGTTGAAAAAAATGTATTCTTTTGTAAAAGATGATTTATTT CAACTAATAAGCGACATAAAGGAAAATATTTTGTTTGAGTCTGAGATTGTTAGTGAGAACAAGC TATATTTTAAAAATAATGATCAATTTTTAAACCTTCTCAACAAACTTTTTAATTGGTATTAAGACT AGAAAGCCAAGAGAATACAAAGAAATTCTTGAGAGCATTAATAAATATGTTTTAGACGATAAT ATTCAGGTATTATTTAGTGATCTTCGCAGAAATTTAAGATTATATAGATTTGCTGAGAGCTCTA AGATTCTTGAAGAGATTATTGAAATGCTTAATAATAAGAGATATTAG t502.nt (SEQ ID NO:416) TGCTTTGTCAACGTCAATTTATTTTCTAAGGATATTTTCAAGTTTAAGCTTGTAGATCAATTTTT TCCTTTTTACTACAAGAATAATAAAGGAGAATATGAAGGACTTATTTTTTCTATTTTAGATAAAT GGGCAAAAGATAATAATGCTGATATTATGGTTGAGCATATTGATAATTTAAATGAAAGTGAAAT TGAAGACGAAGCAATATATTTAGGATTAACTTATAATGTAAAATTAAATGATTTTTTTTATTTTA AAAGTGAGCTTGCTAGGAGTATTTCAATTTTATTTTTTAAAAACTCTAATAAAAAATATAAAAA TACCCATTCAACATTTTTATCCAATTTTAATATAGGAGTTATTAAAAATACAATATATGAAGAT ATCTTAAGGTTAAAAAACGTTAACACCATTTTTTTGGCTGATAATTCTCAAGAGTTAGTATTGG CCTTAAAAAACGATAAAGTTGATTATATATATGGTGATTGCAAGACTTTACATTATATTGCAAA TAACTTTTTAAGTGAAGATCTTGTGATTTTTACCGGGGATGTTTTTTATAGTATCAAAAATAGAG TGGCTATTAGTAGAAATGCTCCTGAGATAGTAAAGAATTTGAATTTAGATTTGTTTTCATATTTA ATGAAAATGCCTGAGGAACTTGTTTTTTCTTTTTTAGATAGCAATGCTAAGGGAAGTTTTGTTG ATGTTGGTTTATATAATGATTATCCTCCTTAAGTTTTATTAATTCACAGGGAAAATTGTCTGGC ATTTTAGTGGATTTGTGGAATCTTCTCTCAAGACAACATATCTTTAAACCTATTTTTAAGGGATT TTCCAAAGAGGATATTAAGAAATCATTAGATGGAAAATCAGTAGGTATTTTTGGAGGAATTATT AGCAATGATAGTGTGTTGGAAAATGTTAATTATGTAGTAAGTAAGCCAATATATCCTCTTAATT TTAAATTTTATTCTAAAGACCTAAGCAATGATGCTGGTCCAATAAATTCTCAGTTTATTGATTTT AATTTTAATAATATTCAATTAAATAAGAATAAAGATATTGTTAATAACTTTATAGATATTGTTA ATAATTCATATGGGTTTATAGAAAATTCAATAACAACAAAATATTTGTTAAAATTAAATGGATA TAACGGTAGATTAAAATCTTACGATTCGATTTTTAATAAAAATAGGTTTTTAGTATTAGCCATTG ATAATAGGATTTATAAGGTTATTAAATATATTCTCAATTCTATATTTGATGATATTTCATTTGAA TCTTTGCTTCAAATAGATAAAAATTGGTTGGATAAAGAAGAGATTAATAGTTCTAGAATAAATA GTTATAAAATTATGAATAAGGTTAAATTTAATATAGAAGAAAAAATTTGGTTATCAAAAAATAA TAAATTAAATCTTGCTGTTAAAAATTGGTATCCAATAGATTATGTTGAGGCAAATAATTATAAA GGAATAAATCAATTTTTGCTTGATAAGATTAGAATGTTTTCAGGTTTGAGATTTAACATAATTA AAGTACACAGCAGTTTAGATCTTAAAAAATTAATCAAATCTGGAAAAATCGATATGCTAAATAC TAATGCAACCGATTCAAATTTAGATAATGTTTTCAACATAAAATTAAATTCTCGAATTCCACTTT ATATTTTTTCAAATAAGAAAAGGGTGCTTCCATCTAGATCTTTAGAAAAGTTTGCTATACTTGAT TTTTTATATAGTAAAAATTTGGCTTCTAATATTAAATCAAAGCTTATTCTGGTAAGCAGTTTTAA TGAAGCGTTGCTTCTTCTTTATAAGGGAAAGGTAGATGGGATTATTAGCGATGAGTATACAGCT GCTGCTGTTTTTGAGGAATTAAATATTGATGATGTTGAAAAAATTCCTACTTTTAGAGATTTGG CTTTTGATTTGAGTCTTGCTATTTATAATCAAGATTATATCTTGAAAGAAATTATTCAAAAAGTT GTTATGCGTTCAAATGTTGACAGTCAGATGTATTTAAATGATTGGAAATTTGATATTTATTATA AATCCAGAAGTATCAGGTTTAAAAATTTCAAATTTTTAGTGATAACATTCATTATATTTTATTTT ACTTTTTTAGGATTTGTAATTATATTTATGTTCAGATTATCATTTGAGCAGAAAAGAAGATATTC TTTTGTGATGAATGAAAAAAAGATTGCGGAAGCCGCTAATGCTGCTAAAACCATTTTTATAGCC AATGTCAGTCATGATATTCGTACCCCTATTAACGGAATAATGGCGGCTACTGAGCTTTTGGATA CAACTATTCTTACAGATGTTCAAAAAGATTATGTTAGGATGATAAATTATTCATCTGATTCTTTG CTTTCTTTTAATTGATGATATATTGTATTTGTCTAAAATAGATGTCAATGAATTATATGTTGAGAG TCAAGAGATTGATTTAGAGAGTGAAATGGAAATGGTTTTAAAAGCTTTTCAATCTCAATGTGCA AAGAAAAATATTGATTTATTCTCTTATTCTAAATCTATTTTTAATAATTATATAAAGGGTGATAT TGTAAAAATTAAACAAGTTTTAATTAATTTAATAGGAAATGCTTTTAAGTTTACAGATGATGGT GTTATTGTTTTAAATTATGAAGAAGTATGTAGAACAAGAACTGATGGTAATAGGGTTTTGGTTA CAGTTGAATTTAAGGTAATAGATACAGGCAAAGGGATTGAAAAAGAAAATTTTTCTAAGATAT TTGAAATATTTAAACAAGAGGATGATTCTTCTTCAAGGGTTCATGAAGGTGCAGGATTGGGATT GTCAATATCTAGAGAGCTTATAAGACTAATGGGTGGTCTTGGTATTGCTGTTGATAGCAAGGTG GGAGAGGGTACAACTTTTTCATTTATGTTGCCCTTTTTATTGGGTAGTGAGCTTAAAAGTAAAA AATTGTCAATCAATAGATTTCAATCAGTAAATGGTGACAATAAAGTATTAAATGTGCTTAAG TCAAAAATCTATTAAAATTTTTGAGCACTGTTCGATTTTATTGGGATGCTCTTCTAATGTGCGCT ATGTAGCGTCTTTTGAGGATGCTTATAAAGTCTTCAAGAAATACCCTTCTTATAATTTTGTTTAT ATAAATGTAAATAACGATAATATTCAAGAGGGTATTCGACTTGCCAATAATATTGAAAGACTAA ATTCTGATGTACAAATTATTTTTTTATTTTATTATTTAGATAATAAAGCTCTAAAAAATTTAAAA TATGGTTATGTTAAAAAGCCTTTAATGGGGCTTGGTATATGCTCTATTCTTTATAAAAAAGAGT TTAACCCAGAAATGGATTTTGAGGATTTGGTTCCAATAGATAGTGCTTTAAGGATAAAAGAGCC CATTAATGTTTTAATAGCTGAAGATAATCAGGTAAATCAAAAAGTGTTGAAAGATATTCTTGTT GTTATAGGCATTAATGAAAATTTTATTGATGTTGTAGATGATGGAGTAAAGGCTTTAAAATCTT TAAAAGATAAAAAATATACTATCTCTTTTATTGATATACGAATGCCAAGATATGATGGATTTTC GGTGGCTAAGGAAATTAGAAAATTTGAAAAGGCAAAGAATTTAAAGCCTTGTGTTTTGGTTGCT GTAACAGCGCATGCTTTGCAAGAGTATAAAGACAAGTGTCTTGCAAGTGGTATGAATGATTATA TCTCAAAACCAATACACATAAGTTCAATTAAAACTATATTAAAAAAATACTTACAGTTTGAAGT TGATGATATTGGGGAGAATGAAAATTTGAATCAACTTGTTAAGTTTCCTAATTTAGATGTTAAT AGGGCTTTAAAAGAATTAAATCTTTCATATGTATCATATTCTGAATTATGTAGAGGGCTTGTTG ATTTTATCTCTATTAATATTATTGATTTGGAAAAAGCTTTTGATGAGGAAGATTTGTCTTTAATT AAGGATATATCTCATTCAATATCTGGAGCTCTTTCTAATATGCGTAGCGAATTGTATAAAGATT TTCAAAAAATTGAAACAAGTAAAGATTCAATTTCTGAGTTGAAAAAAATGTATTCTTTTGTAAA AGATGATTTATTTCAACTAATAAGCGACATAAAGGAAAATATTTTGTTTGAGTCTGAGATTGTT AGTGAGAACAAGCTATATTTTAAAAATAATGATCAATTTTTAAACCTTCTCAACAAACTTTTAA TTGGTATTAAGACTAGAAAGCCAAGAGAATACAAAGAAATTCTTGAGAGCATTAATAAATATG TTTTAGACGATAATATTCAGGTATTATTTAGTGATCTTCGCAGAAATTTAAGATTATATAGATTT GCTGAGAGCTCTAAGATTCTTGAAGAGATTATTGAAATGCTTAATAATAAGAGATATTAG f527.aa (SEQ ID NO:417) MNLLVKIAKFILILFLFTSCNQKQSEIQNLTHLLKSSNKNRLDKFLIIDRVVNIYIANKNYEDALEIVN NGIIDDESREYYPLYLYLMGNIYDSMGEDFVAFNIYKRVVDNFDDYVYENHSMKTRVAKKIVNLNI DSIDKINYYKFILNMGIDNLNNEEKGNYFYNLALSLEDVQDYDESYFYYKKFLSIPRAHLKIDSRDYF NVVTKINYFNNPEFVVYRNLGDLIQDVKNFVLSGNTSKLLNIRDKNNFFIQSWDQKGGKSNSINTNS FLTTMIRLGGRRKNGIQFAKHLEADSSDDISYLESRGWDHIHEWYFVFKRIVYPKDPEINNGWTWIG VYLGKK t527.aa (SEQID NO:418) CNQKQSEIQNLTHLLKSSNKNRLDKFLIIDRVVNIYIANKNYEDALEIVNNGIIDDESREYYPLYLYL MGNIYDSMGEDFVAFNIYKRVVDNFDDYVYENHSMKTRVAKKIVNLNIDSIDKINYYKFILNMGID NLNNEEKGNYFYNLALSLEDVQDYDESYFYYKKFLSIPRAHLKIDSRDYFNVVTKINTYFNNPEFVVY RNLGDLIQDVKNFVLSGNTSKLLNIRDKNNFFIQSWDQKGGKSNSINTNSFLTTMIRLGGRRKNGIQ FAKHLEADSSDDISYLESRGWDHIHEWYFVFKRIVYPKDPEINNGWTWIGVYLGKK f527.nt (SEQ ID NO:419) ATGAATCTATTGGTCAAAATTGCTAAATTTATTTTGATTTTGTTTTTATTTACTTCTTGCAACCA AAAGCAAAGCGAGATTCAAAATCTTACACATCTTTTAAAATCTTCTAATAAAAATAGATTAGAT AAATTTCTTATTATTGATAGAGTTGTTAACATATATATTGCAAATAAAAATTATGAAGATGCTTT AGAAATTGTAAATAATGGAATTATTGATGATGAATCTAGAGAATATTATCCTTTGTATCTTTAT TTAATGGGCAATATTTATGATTCCATGGGAGAAGATTTTGTAGCTTTTAATATTTACAAGCGTG TTGTTGATAATTTTGATGATTATGTTTATGAAAACCATTCAATGAAAACAAGGGTTGCTAAAAA GATTGTCAATTTAAATATTGATTCAATCGATAAAATCAATTATTACAAATTTATATTAAATATGG GGATTGATAATTTAAATAATGAGGAAAAGGGTAATTATTTTTATAATCTTGCGCTAAGTTTGGA AGATGTTCAAGATTACGATGAATCTTATTTTTATTATAAAAAATTTCTTTCAATTCCAAGGGCAC ATTTAAAAATAGATTCTAGAGACTATTTTAATGTTGTTACAAAAATTAATTACTTTAATAATCCA GAGTTTGTTGTTTATAGAAATTTAGGAGATTTAATCCAGGATGTTAAAAATTTTGTTCTTTCTGG TAATACTTCTAAATTGCTTAATATAAGAGATAAGAATAATTTTTTTATTCAAAGCTGGGATCAA AAGGGTGGAAAGAGTAATTCCATTAATACTAATAGCTTTTTAACCACTATGATTAGGCTTGGGG GGAGAAGAAAAAACGGAATACAATTTGCAAAGCATCTTGAGGCAGATTCTAGTGACGATATAT CTTATCTTGAGTCAAGGGGCTGGGACCATATTCATGAATGGTATTTTGTTTTTAAAAGAATTGT TTATCCTAAAGATCCAGAAATTAATAATGGCTGGACTTGGATAGGCGTGTATTTAGGTAAAAAA TAA t527.nt (SEQ ID NO:420) TGCAACCAAAAGCAAAGCGAGATTCAAAATCTTACACATCTTTTAAAATCTTCTAATAAAAATA GATTAGATAAATTTCTTATTATTGATAGAGTTGTTAACATATATATTGCAAATAAAAATTATGA AGATGCTTTAGAAATTGTAAATAATGGAATTATTGATGATGAATCTAGAGAATATTATCCTTTG TATCTTTATTTAATGGGCAATATTTATGATTCCATGGGAGAAGATTTTGTAGCTTTTAATATTTA CAAGCGTGTTGTTGATAATTTTGATGATTATGTTTATGAAAACCATTCAATGAAAACAAGGGTT GCTAAAAAGATTGTCAATTTAAATATTGATTCAATCGATAAAATCAATTATTACAAATTTATAT TAAATATGGGGATTGATAATTTAAATAATGAGGAAAAGGGTAATTATTTTTATAATCTTGCGCT AAGTTTGGAAGATGTTCAAGATTACGATGAATCTTATTTTTATTATAAAAAATTTCTTTCAATTC CAAGGGCACATTTAAAAATAGATTCTAGAGACTATTTTAATGTTGTTACAAAAATTAATTACTT TAATAATCCAGAGTTTGTTGTTTATAGAAATTTAGGAGATTTAATCCAGGATGTTAAAAATTTT GTTCTTTCTGGTAATACTTCTAAATTGCTTAATATAAGAGATAAGAATAATTTTTTATTCAAAG CTGGGATCAAAAGGGTGGAAAGAGTAATTCCATTAATACTAATAGCTTTTTAACCACTATGATT AGGCTTGGGGGGAGAAGAAAAAACGGAATACAATTTGCAAAGCATCTTGAGGCAGATTCTAGT GACGATATATCTTATCTTGAGTCAAGGGGCTGGGACCATATTCATGAATGGTATTTTGTTTTTA AAAGAATTGTTTATCCTAAAGATCCAGAAATTAATAATGGCTGGACTTGGATAGGCGTGTATTT AGGTAAAAAATAA f541.aa (SEQ ID NO:421) MNKILLLILLESIVFLSCSGKGSLGSEIPKVSLIIDGTFDDKSFNESALNGVKKVKEEFKIELVLKESSS NSYLSDLEGLKDAGSDLIWLIGYRFSDVAKVAALQNPDMKYAIIDPIYSNDPIPANLVGMTFRAQEG AFLTGYIAAKLSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISTQYIGSFADLEAGRSVATR MYSDEIDIIHHAAGLGGIGAIEVAKELGSGHYIIGVDEDQAYLAPDNVITSTTKDVGRALNIFTSNHL KTNTFEGGKLINYGLKEGVVGFVRNPKMISFELEKEIDNLSSKIINKEIIVPSNKESYEKFLKEFI t541.aa (SEQ ID NO:422) CSGKGSLGSEIPKVSLIIDGTFDDKSFNESALNGVKKVKEEFKIELVLKESSSNSYLSDLEGLKDAGSD LIWLIGYRFSDVAKVAALQNPDMKYAIIDPIYSNDPIPANLVGMTFRAQEGAFLTGYIAAKLSKTGKI GFLGGIEGEIVDAFRYGYEAGAKYANKDIKISTQYIGSFADLEAGRSVATRMYSDEIDIIHHAAGLGG IGAIEVAKELGSGHYIIGVDEDQAYLAPDNVITSTTKDVGRALNIFTSNHLKTNTFEGGKLINYGLKE GVVGFVRNPKMISFELEKEIDNLSSKIINKEIIVPSNKESYEKFLKE FI f541.nt (SEQ ID NO:423) ATGAATAAAATATTGTTGTTGATTTTGCTTGAGAGTATTGTTTTTTATCTTGTAGTGGTAAAGG TAGTCTTGGGAGCGAAATTCCTAAGGTATCTTTAATAATTGATGGAACTTTTGATGATAAATCT TTTAATGAGAGTGCTTTAAATGGCGTAAAAAAAGTTAAAGAAGAATTTAAAATTGAGCTTGTTT TAAAAGAATCCTCATCAAATTCTTATTTATCTGATCTTGAAGGGCTTAAGGATGCGGGCTCAGA TTTAATTTGGCTTATTGGGTATAGATTTAGCGATGTGGCCAAGGTTGCGGCTCTTCAAAATCCC GATATGAAATATGCAATTATTGATCCTATTTATTCTAACGATCCTATTCCTGCAAATTTGGTGGG CATGACCTTTAGAGCTCAAGAGGGTGCATTTTTAACGGGTTATATTGCTGCAAAACTTTCTAAA ACAGGTAAAATTGGATTTTTAGGGGGAATAGAAGGCGAGATAGTAGATGCTTTTAGGTATGGG TATGAAGCTGGTGCTAAGTATGCTAATAAAGATATAAAGATATCTACTCAGTATATTGGTAGTT TTGCTGACCTTGAAGCTGGTAGAAGCGTTGCAACTAGGATGTATTCTGATGAGATAGACATTAT TCATCATGCTGCAGGCCTTGGAGGAATTGGGGCTATTGAGGTTGCAAAAGAACTTGGTTCTGGG CATTACATTATTGGAGTTGATGAAGATCAAGCATATCTTGCTCCTGACAATGTAATAACATCTA CAACTAAAGATGTTGGTAGAGCTTTAAATATTTTTACATCTAACCATTTAAAAACTAATACTTTC GAAGGTGGCAAATTAATAAATTATGGCCTTAAAGAAGGAGTTGTGGGGTTTGTAAGAAATCCT AAAATGATTTCCTTTGAACTTGAAAAAGAAATTGACAATCTTTCTAGCAAAATAATCAACAAAG AAATTATTGTTCCATCTAATAAAGAAAGTTATGAGAAGTTTCTTAAAGAATTTATTTAA t541.nt (SEQ ID NO:424) TGTAGTGGTAAAGGTAGTCTTGGGAGCGAAATTCCTAAGGTATCTTTAATAATTGATGGAACTT TTGATGATAAATCTTTTTAATGAGAGTGCTTTAAATGGCGTAAAAAAAGTTAAAGAAGAATTTAA AATTGAGCTTGTTTTAAAAGAATCCTCATCAAATTCTTATTTATCTGATCTTGAAGGGCTTAAGG ATGCGGGCTCAGATTTAATTTGGCTTATTGGGTATAGATTTAGCGATGTGGCCAAGGTTGCGGC TCTTCAAAATCCCGATATGAAATATGCAATTATTGATCCTATTTATTCTAACGATCCTATTCCTG CAAATTTGGTGGGCATGACCTTTAGAGCTCAAGAGGGTGCATTTTTAACGGGTTATATTGCTGC AAAACTTTCTAAAACAGGTAAAATTGGATTTTTAGGGGGAATAGAAGGCGAGATAGTAGATGC TTTTAGGTATGGGTATGAAGCTGGTGCTAAGTATGCTAATAAAGATATAAAGATATCTACTCAG TATATTGGTAGTTTTGCTGACCTTGAAGCTGGTAGAAGCGTTGCAACTAGGATGTATTCTGATG AGATAGACATTATTCATCATGCTGCAGGCCTTGGAGGAATTGGGGCTATTGAGGTTGCAAAAG AACTTGGTTCTGGGCATTACATTATTGGAGTTGATGAAGATCAAGCATATCTTGCTCCTGACAA TGTAATAACATCTACAACTAAAGATGTTGGTAGAGCTTTAAATATTTTTACATCTAACCATTTAA AAACTAATACTTTCGAAGGTGGCAAATTAATAAATTATGGCCTTAAAGAAGGAGTTGTGGGGTT TGTAAGAAATCCTAAAATGATTTCCTTTGAACTTGAAAAAGAAATTGACAATCTTTCTAGCAAA ATAATCAACAAAGAAATTATTGTTCCATCTAATAAAGAAAGTTATGAGAAGTTTCTTAAAGAAT TTATTTAA f561.aa (SEQ ID NO:425) MYKNGFFKNYLSLFLIFLVIACTSKDSSNEYVEEQEAENSSKPDDSKIDEHTIGHVFHAMGVVHSKK DRKSLGKNIKVFYFSEEDGHFQTIPSKENAKLIVYFYDNVYAGEAPISISGKEAFIFVGITPDFKKIINS NLHGAKSDLIGTFKDLNIKNSKLEITVDENNSDAKTFLESVNYIIDGVEKISPMLTN t561.aa (SEQ ID NO:426) CTSKDSSNEYVEEQEAENSSKPDDSKIDEHTIGHVFHAMGVVHSKKDRKSLGKNIKVFYFSEEDGHF QTIPSKENAKLIVYFYDNVYAGEAPISISGKEAFIFVGITPDFKKIINSNLHGAKSDLIGTFKDLNIKNS KLEITVDENNSDAKTFLESVNYIIDGVEKISPMLTN f561.nt (SEQ ID NO:427) ATGTATAAAAATGGTTTTTTTAAAAACTATTTGTCATTGTTTTTAATTTTTTTAGTAATTGCTTGT ACTTCAAAAGATAGCTCAAATGAATATGTTGAGGAGCAAGAAGCGGAGAACTCTTCTAAGCCT GATGATTCTAAAATAGATGAACATACTATTGGGCACGTTTTTCACGCTATGGGAGTAGTTCATT CAAAAAAGGATCGAAAAAGTTTGGGGAAAAATATAAAGGTTTTTTATTTTTCTGAAGAAGATG GACATTTTCAAACAATACCCTCAAAAGAGAATGCAAAGTTAATAGTTTATTTTTATGACAATGT TTATGCAGGAGAGGCTCCAATTAGTATCTCTGGAAAAGAAGCCTTTATTTTTGTTGGGATTACC CCTGACTTTAAAAAGATTATAAATAGCAATTTACATGGCGCTAAAAGTGATCTTATTGGTACTT TTAAAGATCTTAATATTAAAAATTCAAAATTGGAAATTACAGTTGATGAGAATAATTCAGATGC CAAGACCTTCCTTGAATCTGTTAATTACATTATCGACGGCGTTGAAAAAATTTCACCTATGTTAA CGAATTAA t561.nt (SEQ ID NO:428) TGTACTTCAAAAGATAGCTCAAATGAATATGTTGAGGAGCAAGAAGCGGAGAACTCTTCTAAG CCTGATGATTCTAAAATAGATGAACATACTATTGGGCACGTTTTTCACGCTATGGGAGTAGTTC ATTCAAAAAAGGATCGAAAAAGTTTGGGGAAAAATATAAAGGTTTTTTATTTTTCTGAAGAAGA TGGACATTTTCAAACAATACCCTCAAAAGAGAATGCAAAGTTAATAGTTTATTTTTATGACAAT GTTTATGCAGGAGAGGCTCCAATTAGTATCTCTGGAAAAGAAGCCTTTATTTTTGTTGGGATTA CCCCTGACTTTAAAAAGATTATAAATAGCAATTTACATGGCGCTAAAAGTGATCTTATTGGTAC TTTTAAAGATCTTAATATTAAAAATTCAAAATTGGAAATTACAGTTGATGAGAATAATTCAGAT GCCAAGACCTTCCTTGAATCTGTTAATTACATTATCGACGGCGTTGAAAAAATTTCACCTATGTT AACGAATTAA f604.aa (SEQ ID NO:429) MSFNKTKKIGKKIKIVTLLMLAVSLIACNNNSEKEKLAFKVYIGGAPSSLDPHLVDETIGARILEQIFS GLLTLNTKTGKLKPGLAKNWEASKDKKTYQFYLRDNLFWSDGVEITAEGIRKSFLRILNKETGSTN VDMLKSIIKNGQEYFDGKVSDSELGIKAIDSKTLEITLTAPKPYFLELLLHYAFMPVPIHVIEKYKGN WTSPENMVTSGPFKLKKRLPNEKIIFEKNERYYNAKEVELDELVYITSDNDLTVYNMYKNNEIDAIF NSIPPDIVNEIKLQKDYYQHKSNAIYLYSFNTKIKPLDDARVREALTLAIDRETLTYKVLNDGTVPTR EITPDLKNYNYGKKLALFDPEKSKKLLADAGYPNGKGFPMLTLKYNTNETHKKIAAFIQNQWKKIL NINLMLTNENWPVLTNSRNTGNFEIIRVGRIGEYLDPHTYFTIFTRENSQLASYGYSNLEFDKLIRESD LEKDPIKRKQLLRKAESIIIEKDFPAAPIYIYSGHYLFRNDKWTGWNPNVSEVYYLSELKPIKNAKHN t604.aa (SEQ ID NO:430) CNNNSEKEKLAFKVYIGGAPSSLDPHLVDETIGARILEQIFSGLLTLNTKTGKLKPGLAKNWEASKD KKTYQFYLRDNLFWSDGVEITAEGIRKSFLRILNKETGSTNVDMLKSIIKNGQEYFDGKVSDSELGIK AIDSKTLEITLTAPKPYFLELLLHYAFMPVPIHVIEKYKGNWTSPENMVTSGPFKLKKRLPNEKIIFEK NERYYNAKEVELDELVYITSDNDLTVYNMYKNNEIDAIFNSIPPDIVNEIKLQKDYYQHKSNAIYLY SFNTKIKPLDDARVREALTLAIDRETLTYKVLNDGTVPTREITPDLKNYNYGKKLALFDPEKSKKLL ADAGYPNGKGFPMLTLKYNTNETHKKIAAFIQNQWKKILNINLMLTNENWPVLTNSRNTGNFEIIR VGRIGEYLDPHTYFTIFTRENSQLASYGYSNLEFDKLIRESDLEKDPIKRKQLLRKAESIIIEKDFPAAP IYIYSGHYLFRNDKWTGWNPNVSEVYYLSELKPIKNAKHN f604.nt (SEQ ID NO:431) ATGAGCTTTAATAAAACTAAAAAAATCGGTAAAAAAATTAAAATAGTAACACTACTTATGCTTG CTGTGTCTTTAATTGCATGCAATAATAATTCAGAAAAAGAAAAATTAGCATTTAAAGTATACAT AGGGGGAGCGCCCTCATCGCTTGACCCTCATTTGGTAGATGAGACAATAGGAGCAAGAATTTTA GAACAAATATTCTCAGGGCTTTTGACATTAAATACCAAAACAGGAAAGCTAAAGCCCGGACTTG CTAAAAATTGGGAAGCCTCAAAAGATAAAAAAACATATCAATTTTATCTAAGGGACAACCTTTT TTGGAGCGATGGAGTTGAAATTACCGCTGAAGGGATAAGAAAATCTTTTTTAAGAATTTTAAAT AAAGAAACAGGATCTACAAATGTTGACATGCTCAAATCAATAATAAAAAATGGACAAGAGTAT TTTGACGGGAAAGTATCCGATTCTGAACTTGGAATCAAGGCAATTGATAGTAAAACGCTGGAA ATAACACTTACGGCCCCAAAGCCATATTTTCTTGAACTGCTTCTACATTACGCATTCATGCCAGT ACCTATTCATGTGATTGAAAAATATAAGGGAAATTGGACAAGCCCTGAAAACATGGTTACTAGC GGTCCTTTTAAATTAAAAAAAAGATTACCTAATGAAAAAATTATCTTTGAAAAAAACGAACGTT ATTATAATGCAAAAGAAGTAGAACTTGATGAGCTTGTCTACATTACGTCTGACAATGATCTTAC TGTGTACAATATGTACAAAAACAACGAAATTGATGCTATTTTTAACAGCATCCCGCCGGACATT GTAAATGAAATAAAACTACAAAAAGACTATTACCAACACAAAAGTAATGCAATTTATTTATATT CATTTAATACAAAAATAAAACCCCTTGATGATGCTAGAGTTAGAGAAGCTTTAACCTTAGCTAT TGACAGAGAAACTTTAACTTACAAAGTGCTAAATGATGGCACAGTTCCTACAAGAGAAATAACT CCTGATCTTAAAAATTACAATTACGGTAAAAAATTGGCTTTATTTGATCCTGAAAAATCTAAAA AGCTTTTGGCAGATGCAGGGTATCCTAATGGGAAAGGATTCCCAATGCTAACACTAAAATATAA TACAAACGAAACTCATAAAAAAATTGCTGCATTTATTCAAAACCAATGGAAAAAAATTCTAAAT ATCAATCTTATGCTTACCAACGAAAATTGGCCTGTTCTTACCAACAGCAGAAATACTGGCAATT TTGAAATAATAAGAGTTGGACGCATTGGGGAATATTTAGATCCACACACATACTTTACTATATT CACAAGAGAAAATTCACAACTTGCATCATACGGATATTCAAACCTAGAATTTGACAAACTCATC AGAGAATCAGATCTTGAAAAAGATCCTATAAAAAGAAAACAATTACTCAGAAAAGCAGAATCA ATAATAATTGAAAAAGATTTTCCTGCTGCACCAATATACATATATTCTGGGCATTATCTTTTTAG AAACGATAAATGGACTGGATGGAATCCTAATGTATCAGAGGTTTATTATCTTTCTGAATTAAAA CCAATTAAAAATGCAAAACATAATTAA t604.nt (SEQ ID NO:432) TGCAATAATAATTCAGAAAAAGAAAAATTAGCATTTAAAGTATACATAGGGGGAGCGCCCTCA TCGCTTGACCCTCATTTGGTAGATGAGACAATAGGAGCAAGAATTTTAGAACAAATATTCTCAG GGCTTTTGACATTAAATACCAAAACAGGAAAGCTAAAGCCCGGACTTGCTAAAAATTGGGAAG CCTCAAAAGATAAAAAAACATATCAATTTTATCTAAGGGACAACCTTTTTTGGAGCGATGGAGT TGAAATTACCGCTGAAGGGATAAGAAAATCTTTTTTAAGAATTTTAAATAAAGAAACAGGATCT ACAAATGTTGACATGCTCAAATCAATAATAAAAAATGGACAAGAGTATTTTGACGGGAAAGTA TCCGATTCTGAACTTGGAATCAAGGCAATTGATAGTAAAACGCTGGAAATAACACTTACGGCCC CAAAGCCATATTTTCTTGAACTGCTTCTACATTACGCATTCATGCCAGTACCTATTCATGTGATT GAAAAATATAAGGGAAATTGGACAAGCCCTGAAAACATGGTTACTAGCGGTCCTTTTAAATTA AAAAAAAGATTACCTAATGAAAAAATTATCTTTGAAAAAAACGAACGTTATTATAATGCAAAA GAAGTAGAACTTGATGAGCTTGTCTACATTACGTCTGACAATGATCTTACTGTGTACAATATGT ACAAAAACAACGAAATTGATGCTATTTTTAACAGCATCCCGCCGGACATTGTAAATGAAATAAA ACTACAAAAAGACTATTACCAACACAAAAGTAATGCAATTTATTTATATTCATTTAATACAAAA ATAAAACCCCTTGATGATGCTAGAGTTAGAGAAGCTTTAACCTTAGCTATTGACAGAGAAACTT TAACTTACAAAGTGCTAAATGATGGCACAGTTCCTACAAGAGAAATAACTCCTGATCTTAAAAA TTACAATTACGGTAAAAAATTGGCTTTATTTGATCCTGAAAAATCTAAAAAGCTTTTGGCAGAT GCAGGGTATCCTTAATGGGAAAGGATTCCCAATGCTAACACTAAAATATAATACAAACGAAACT CATAAAAAAATTGCTGCATTTATTCAAAACCAATGGAAAAAAATTCTAAATATCAATCTTATGC TTACCAACGAAAATTGGCCTGTTCTTACCAACAGCAGAAATACTGGCAATTTTGAAATAATAAG AGTTGGACGCATTGGGGAATATTTAGATCCACACACATACTTTACTATATTCACAAGAGAAAAT TCACAACTTGCATCATACGGATATTCAAACCTAGAATTTGACAAACTCATCAGAGAATCAGATC TTGAAAAAGATCCTATAAAAAGAAAACAATTACTCAGAAAAGCAGAATCAATAATAATTGAAA AAGATTTTCCTGCTGCACCAATATACATATATTCTGGGCATTATCTTTTTAGAAACGATAAATG GACTGGATGGAATCCTAATGTATCAGAGGTTTATTATCTTTCTGAATTAAAACCAATTAAAAAT GCAAAACATAATTAA f736.aa (SEQ ID NO:433) MKKVIILIFMLSTSLLYNCKNQDNEKIVSIGGSTTVSPILDEMILRYNKINNNTKVTYDAQGSSVGIN GLFNKIYKIAISSRDLTKEEIEQGAKETVFAYDALIFITSPEIKITNITEENLAKILNGEIQNWKQVGGP DAKINFINRDSSSGSYSSIKDLLLNKIFKTHEEAQFRQDGIVVKSNGEVIEKTSLTPHSIGYIGLGYAK NSIEKGLNILSVNSTYPTKETINSNKYTIKRNLIIVTNNKYEDKSVTQFIDFMTSSTGQDIVEEQGFLGI KT t736.aa (SEQ ID NO:434) CKNQDNEKIVSIGGSTTVSPILDEMILRYNKINNNTKVTYDAQGSSVGINGLFNKIYKIAISSRDLTKE EIEQGAKETVFAYDALIFITSPEIKITNITEENLAKILNGEIQNWKQVGGPDAKINFINRDSSSGSYSSIK DLLLNKIFKTHEEAQFRQDGIVVKSNGEVIEKTSLTPHSIGYIGLGYAKNSIEKGLNILSVNSTYPTKE TINSNKYTIKRNLIIVTNNKYEDKSVTQFIDFMTSSTGQDIVEEQGFLGIKT f736.nt (SEQ ID NO:435) ATGAAAAAAGTTATTATCTTAATTTTTATGCTATCAACAAGTTTATTATACAACTGTAAAAATCA AGACAATGAAAAAATTGTATCAATTGGAGGATCTACAACTGTAAGCCCAATACTAGACGAAAT GATTTTAAGATATAATAAAATAAACAATAATACTAAAGTAACATACGATGCACAAGGAAGTAG TGTTGGCATAAACGGGCTATTTAACCAAAATATATAAAATAGCAATATCATCAAGAGATTTAACA AAAGAAGAAATTGAACAAGGGGCAAAAGAAACTGTATTTGCTTATGATGCTTTAATTTTCATTA CAAGCCCTGAAATAAAAATTACAAATATTACAGAAGAAAATCTAGCTAAAATACTAAATGGAG AAATTCAAAATTGGAAACAAGTGGGAGGTCCTGATGCTAAAATCAACTTTATCAATCGAGACTC TTCTTCTGGTTCTTATTCGTCTATAAAAGACCTACTTCTTAATAAAATATTCAAAACTCACGAAG AAGCTCAATTTAGACAAGACGGAATAGTGGTAAAATCTAATGGAGAGGTAATTGAAAAAACAA GCCTTACTCCCCACTCAATAGGATATATAGGTCTTGGATACGCAAAAAATTCAATAGAAAAGGG TTTGAATATTCTTTCTGTTAACAGCACATATCCTACAAAAGAAACAATAAATAGCAATAAATAC ACCATTAAAAGAAATTTAATAATAGTTACAAATAACAAATACGAGGATAAAAGCGTAACTCAA TTTATTGATTTCATGACAAGCTCAACTGGACAAGATATTGTTGAAGAACAAGGCTTTTTAGGGA TAAAAACATAA t736.nt (SEQ ID NO:436) TGTAAAAATCAAGACAATGAAAAAATTGTATCAATGGAGGATCTACAACTGTAAGCCCAATA CTAGACGAAATGATTTTAAGATATAATAAAATAAACAATAATACTAAAGTAACATACGATGCAC AAGGAAGTAGTGTTGGCATAAACGGGCTATTTAACAAAATATATAAAATAGCAATATCATCAA GAGATTTAACAAAAGAAGAAATTGAACAAGGGGCAAAAGAAACTGTATTTGCTTATGATGCTT TAATTTTCATTACAAGCCCTGAAATAAAAATTACAAATATTACAGAAGAAAATCTAGCTAAAAT ACTAAATGGAGAAATTCAAAATTGGAAACAAGTGGGAGGTCCTGATGCTAAAATCAACTTTAT CAATCGAGACTCTTCTTCTGGTTCTTATTCGTCTATAAAAGACCTACTTCTTAATAAAATATTCA AAACTCACGAAGAAGCTCAATTTAGACAAGACGGAATAGTGGTAAAATCTAATGGAGAGGTAA TTGAAAAAACAAGCCTTACTCCCCACTCAATAGGATATATAGGTCTTGGATACGCAAAAAATTC AATAGAAAAGGGTTTGAATATTCTTTCTGTTAACAGCACATATCCTACAAAAGAAACAATAAAT AGCAATAAATACACCATTAAAAGAAATTTAATAATAGTTACAAATAACAAATACGAGGATAAA AGCGTAACTCAATTTATTGATTTCATGACAAGCTCAACTGGACAAGATATTGTTGAAGAACAAG GCTTTTTAGGGATAAAAACATAA f752.aa (SEQ ID NO:437) MNKKLNEVLLKLDQDLIKCVKGSLDLEISGVTYSSKLVLPRFVFFALPGIHFDGHDFIEIAIQKGSNV VVCSRDVDFYSPNVTYIKVDDFNIRKFMSNFSNIFYDEPSKKLKVIGVTGTDGKSSVCYYIYLLFKK KGVKVGFISTVFFDDGSGSLIKNPYRQSTPESTEIHSFLSTMVKNEAQYAILESTSHGLDLETARLIDV NYFAVVFTNIGHEHLEFHGTIQNYLNVKLGLFRSVSDDAGFGVINLDDLYSSDFKNAVKKSFTYSLK SSKADFFVSFIDEKTDSTRFEFYHKGVKYLANVSLLGSFNVENVMAALILVSQILNIDIQDIVDKLNCI KSLDGRMDSINLGQNFSVIIDYAHTPGAFSKLFPIFKRFATNRLISVFGSAGERDVEKRFLQGQIADIY SDLIILCDEDPRGENSMCIIKDIAKGIVNKVENKDLFFIADRKQAIEKAISLAKAGDLVVALGKGHESS IIYKNREVFWNEQEVVKNAILSLEKSEKEK t752.aa (SEQ ID NO:438) CVKGSLDLEISGVTYSSKLVLPRFVFFALPGIHFDGHDFIEIAIQKGSNVVVCSRDVDFYSPNVTYIKV DDFNIRKFMSNFSNIFYDEPSKKLKVIGVTGTDGKSSVCYYIYLLFKKKGVKVGFISTVFFDDGSGSL IKNPYRQSTPESTEIHSFLSTMVKNEAQYAILESTSHGLDLETARLIDVNYFAVVFTNIGHEHLEFHGT IQNYLNVKLGLFRSVSDDAGFGVINLDDLYSSDFKNAVKKSFTYSLKSSKADFFVSFIDEKTDSTRFE FYHKGVKYLANVSLLGSFNVENVMAALILVSQILNIDIQDIVDKLNCIKSLDGRMDSINLGQNFSVII DYAHTPGAFSKLFPIFKRFATNRLISVFGSAGERDVEKRFLQGQIADIYSDLIILCDEDPRGENSMCIIK DIAKGIVNKVENKDLFFIADRKQAIEKAISLAKAGDLVVALGKGHESSIIYKNREVFWNEQEVVKNA ILSLEKSEKEK f752.nt (SEQ ID NO:439) ATGAATAAAAAACTTAATGAAGTTTTATTAAAGTTAGATCAAGATTTAATAAAATGTGTAAAAG GTTCTCTTGATTTAGAAATATCAGGAGTTACTTATAGTTCTAAATTGGTTTTGCCCAGGTTTGTG TTTTTTGCTCTTCCAGGAATTCATTTTGATGGGCATGATTTTATTGAAATTGCAATTCAAAAGGG TAGTAATGTTGTTGTGTGTTCACGAGATGTGGATTTTTACAGTCCTAATGTTACTTATATTAAGG TAGATGAGTTTAACATAAGAAAATTTATGTCTAATTTTTCAAATATTTTTTATGATGAGCCTTCA AAAAAATTAAAAGTTATTGGAGTCACTGGCACTGACGGGAAAAGTTCTGTTTGTTATTATATAT ATCTTCTTTTTAAAAAAAAGGGTGTTAAAGTAGGTTTTATATCGACAGTATTTTTTGATGATGG GAGTGGAAGCTTGATTAAAAATCCTTACAGACAATCAACTCCCGAGTCTACGGAAATACATTCA TTTTTAAGCACCATGGTTAAAAATGAAGCTCAATATGCAATTCTTGAATCTACTTCTCATGGGCT TGACCTTGAAACAGCAAGGCTTATTGATGTTAATTATTTTGCAGTTGTTTTTACCAATATTGGAC ATGAGCATCTTGAATTTCATGGCACAATTCAAAATTATTTGAATGTCAAGCTGGGTCTTTTTCG GTCTGTTAGTGATGATGCTGGTTTTGGGGTTATTAATCTTGATGACCTTTATTCTTCTGATTTTA AGAATGCTGTTAAGAAATCTTTTACTTATAGCTTAAAAAGCAGTAAAGCGGATTTTTTTGTTAG TTTTATTGATGAGAAAACCGATTCTACTAGATTTGAATTTTATCACAAGGGGGTTAAATATCTT GCTAATGTTAGCCTACTGGGGAGTTTTAATGTTGAGAATGTAATGGCTGCTCTTATTTTAGTTTC TCAAATTTTAAATATCGATATTCAAGATATTGTTGATAAACTTAACTGCATTAAAAGTCTTGAT GGGCGTATGGATAGTATTAATTTGGGGCAAAATTTTTGTAATAATTGATTATGCTCATACTC CTGGTGCTTTTTCCAAGCTTTTTCCTATTTTTAAAAGATTTGCTACCAATAGATTGATTTCTGTTT TTGGCTCTGCAGGAGAAAGAGATGTTGAAAAAAGATTTTTGCAAGGGCAAATCGCAGATATTT ATTCTGATTTAATAATACTTTGCGATGAAGATCCAAGAGGCGAGAATAGTATGTGTATAATTAA AGACATTGCAAAAGGAATTGTAAATAAAGTTGAAAATAAGGATTTATTTTTTATTGCTGATAGA AAGCAGGCTATTGAAAAAGCAATAAGTCTTGCAAAAGCAGGAGATTTGGTTGTTGCTTTGGGC AAAGGTCATGAAAGTTCAATAATTTATAAAAATAGAGAAGTTTTTTGGAATGAACAAGAGGTA GTTAAAAATGCTATTTTAAGTTTAGAAAAATCAGAAAAGGAGAAGTGA t752.nt (SEQ ID NO:440) TGTGTAAAAGGTTCTCTTGATTTAGAAATATCAGGAGTTACTTATAGTTCTAAATTGGTTTTGCC CAGGTTTGTGTTTTTTGCTCTTCCAGGAATTCATTTTGATGGGCATGATTTTATTGAAATTGCAA TTCAAAAGGGTAGTAATGTTGTTGTGTGTTCACGAGATGTGGATTTTTACAGTCCTAATGTTAC TTATATTAAGGTAGATGACTTTAACATAAGAAAATTTATGTCTAATTTTTCAAATATTTTTTATG ATGAGCCTTCAAAAAAATTAAAAGTTATTGGAGTCACTGGCACTGACGGGAAAAGTTCTGTTTG TTATTATATATATCTTCTTTTTAAAAAAAAGGGTGTTAAAGTAGGTTTTATATCGACAGTATTTT TTGATGATGGGAGTGGAAGCTTGATTAAAAATCCTTACAGACAATCAACTCCCGAGTCTACGGA AATACATTCATTTTTAAGCACCATGGTTAAAAATGAAGCTCAATATGCAATTCTTGAATCTACTT CTCATGGGCTTGACCTTGAAACAGCAAGGCTTATTGATGTTAATTATTTTGCAGTTGTTTTTACC AATATTGGACATGAGCATCTTGAATTTCATGGCACAATTCAAAATTATTTGAATGTCAAGCTGG GTCTTTTTCGGTCTGTTAGTGATGATGCTGGTTTTGGGGTTATTAATCTTGATGACCTTTATTCT TCTGATTTTAAGAATGCTGTTAAGAAATCTTTTACTTATAGCTTAAAAAGCAGTAAAGCGGATT TTTTTGTTAGTTTTATTGATGAGAAAACCGATTCTACTAGATTTGAATTTTATCACAAGGGGGTT AAATATCTTGCTAATGTTAGCCTACTGGGGAGTTTTAATGTTGAGAATGTAATGGCTGCTCTTA TTTTAGTTTCTCAAATTTTAAATATCGATATTCAAGATATTGTTGATAAACTTAACTGCATTAAA AGTCTTGATGGGCGTATGGATAGTATTAATTTGGGGCAAAATTTTTCTGTAATAATTGATTATG CTCATACTCCTGGTGCTTTTTCCAAGCTTTTTCCTATTTTTAAAAGATTTGCTACCAATAGATTG ATTTCTGTTTTTGGCTCTGCAGGAGAAAGAGATGTTGAAAAAAGATTTTTGCAAGGGCAAATCG CAGATATTTATTCTGATTTAATAATACTTTGCGATGAAGATCCAAGAGGCGAGAATAGTATGTG TATAATTAAAGACATTGCAAAAGGAATTGTAAATAAAGTTGAAAATAAGGATTTATTTTTTATT GCTGATAGAAAGCAGGCTATTGAAAAAGCAATAAGTCTTGCAAAAGCAGGAGATTTGGTTGTT GCTTTGGGCAAAGGTCATGAAAGTTCAATAATTTATAAAAATAGAGAAGTTTTTTGGAATGAAC AAGAGGTAGTTAAAAATGCTATTTTAAGTTTAGAAAAATCAGAAAAGGAGAAGTGA f798.aa (SEQ ID NO:441) MVFRTYKHLELIMLPMLMLSCAFFKKPQSVHQDSNTGKPISDEKLHLISGKISNKKLPIINSNHDVTW IKTKAMTILGEDGKEIPEFKNKFGYSYIISPVKMDGKYSYYASLLILFETTKNGDDEYEIEDVKFVTA GSTLELKNSLLAVENSQEEGYVTAYPFGILMSDEIKNAFKLTYKNGHWNYMLADLTVKNKLTQET KIYKISLNSKLIIEFLKEVLKENSILKDIAGDLFEDI t798.aa (SEQ ID NO:442) CAFFKKPQSVHQDSNTGKPISDEKLHLISGKISNKKLPIINSNHDVTWIKTKAMTILGEDGKEIPEFKN KFGYSYIISPVKMDGKYSYYASLLILFETTKNGDDEYEIEDVKFVTAGSTLELKNSLLAVENSQEEGY VTAYPFGILMSDEIKNAFKLTYKNGHWNYMLADLTVKNKLTQETKIYKISLNSKLIIEFLKEVLKEN SILKDIAGDLFEDI f798.nt (SEQ ID NO:443) ATGGTATTTAGAACATATAAACATTTGGAACTAATAATGCTGCCCATGTTAATGCTGAGTTGCG CTTTTTTTAAGAAACCACAATCTGTACATCAAGACAGCAATACTGGCAAACCAATAAGCGATGA AAAATTACATTTAATATCAGGCAAAATTTCAAATAAAAAATTGCCAATCATAAATAGTAATCAT GACGTAACTTGGATAAAAACAAAGGCAATGACAATCTTAGGCGAAGATGGAAAAGAAATACCA GAATTTAAAAACAAATTTGGATATTCTTATATAATATCTCCTGTAAAAATGGATGGAAAATATA GTTATTACGCGTCATTATTAATACTTTTGAAACAACTAAAAATGGAGATGATGAATATGAAAT TGAAGATGTTAAATTTGTAACAGCTGGTTCCACCCTAGAACTTAAAAATTCTCTTTTAGCTGTTG AAAATTCACAAGAAGAAGGATATGTTACTGCATACCCATTTGGAATATTGATGAGTGACGAGAT TAAAAATGCTTTTAAATTAACATATAAAAATGGTCATTGGAATTATATGCTTGCAGATTTAACT GTCAAAAATAAACTTACTCAAGAAACTAAAATTTATAAAATTTCTCTTAATTCAAAATTAATTA TTGAATTTTTAAAAGAAGTGCTAAAAGAAAATTCTATATTAAAAGACATAGCTGGAGATTTATT TGAAGATATATAA t798.nt (SEQ ID NO:444) TGCGCTTTTTTTAAGAAACCACAATCTGTACATCAAGACAGCAATACTGGCAAACCAATAAGCG ATGAAAAATTACATTTAATATCAGGCAAAATTTCAAATAAAAAATTGCCAATCATAAATAGTAA TCATGACGTAACTTGGATAAAAACAAAGGCAATGACAATCTTAGGCGAAGATGGAAAAGAAAT ACCAGAATTTAAAAACAAATTTGGATATTCTTATATAATATCTCCTGTAAAAATGGATGGAAAA TATAGTTATTACGCGTCATTATTAATACTTTTTGAAACAACTAAAAATGGAGATGATGAATATG AAATTGAAGATGTTAAATTTGTAACAGCTGGTTCCACCCTAGAACTTAAAAATTCTCTTTTAGCT GTTGAAAATTCACAAGAAGAAGGATATGTTACTGCATACCCATTTGGAATATTGATGAGTGACG AGATTAAAAATGCTTTTAAATTAACATATAAAAATGGTCATTGGAATTATATGCTTGCAGATTT AACTGTCAAAAATAAACTTACTCAAGAAACTAAAATTTATAAAATTTCTCTTAATTCAAAATTA ATTATTGAATTTTTAAAAGAAGTGCTAAAAGAAAATTCTATATTAAAAGACATAGCTGGAGATT TATTTGAAGATATATAA f805.aa (SEQ ID NO:445) MLRKLKDISKIVLVTDGLTPNCQTCGKLIANGDEVYIAEDGLFHSVKSNTIAGSTLTMIQGLKNLIEF GFSLSDAVQASSYNPTRILNIDKKGLICHGYDANLNVLDKDFNLKLTMIESKIIFNNL t805.aa (SEQ ID NO:446) CQTCGKLIANGDEVYIAEDGLFHSVKSNTIAGSTLTMIQGLKNLIEFGFSLSDAVQASSYNPTRILNID KKGLICHGYDANLNVLDKDFNLKLTMIESKIIFNNL f805.nt (SEQ ID NO:447) ATGCTTAGAAAGCTTAAAGATATAAGTAAAATAGTCCTTGTAACTGACGGACTTACTCCGAATT GTCAAACTTGTGGAAAACTAATTGCAAACGGAGACGAAGTTTATATTGCAGAAGATGGATTATT CCATAGCGTGAAAAGCAACACAATAGCTGGATCAACACTCACAATGATACAAGGTCTTAAAAA TTTAATAGAATTTGGTTTCAGCTTAAGCGATGCTGTTCAAGCAAGCTCTTACAATCCAACAAGA ATTCTCAATATTGATAAAAAGGGCTTAATATGTCATGGATATGATGCAAACCTCAATGTCCTAG ATAAAGATTTTAATCTAAAGTTAACAATGATAGAATCTAAAATAATTTTTAACAATCTCTAA f805.nt (SEQ ID NO:448) TGTCAAACTTGTGGAAAACTAATTGCAAACGGAGACGAAGTTTATATTGCAGAAGATGGATTAT TCCATAGCGTGAAAAGCAACACAATAGCTGGATCAACACTCACAATGATACAAGGTCTTAAAA ATTTAATAGAATTTGGTTTCAGCTTAAGCGATGCTGTTCAAGCAAGCTCTTACAATCCAACAAG AATTCTCAATATTGATAAAAAGGGCTTAATATGTCATGGATATGATGCAAACCTCAATGTCCTA GATAAAGATTTTAATCTAAAGTTAACAATGATAGAATCTAAAATAATTTTTAACAATCTCTAA f635.aa (SEQ ID NO:449) MKILWLIILVNLFLSCGNESKEKSNLGLRLRELEISGGGSESKIEVYKEFIEKEDKNILKIVNSI DKKARFFNLIGLEFFKLGQYGPAIEYFAKNLEINPNNYLSHFYIGVASYNLAKNLRVKDEVEKYIILA ENSFLKSLSIRDDFKDSLFAISNMYVYDLDKQLEAKNYLNKLGDMGEDYFEFLMLRGANYYSLGDL GNAILFYDKASKKASTEEQKEGVSRIMSNLK t635.aa (SEQ ID NO:450) CGNESKEKSNLGLRLRELEISGGGSESKIEVYKEFIEKEDKNILKIVNSIDKKARFFNLIGLEFFKLGQY GPAIEYFAKNLEINPNNYLSHFYIGVASYNLAKNLRVKDEVEKYIILAENSFLKSLSIRDDFKDSLFAI SNMYVYDLDKQLEAKNYLNKLGDMGEDYFEFLMLRGANYYSLGDLGNAILFYDKASKKASTEEQ KEGVSRIMSNLK f635.nt (SEQ ID NO:451) ATGAAAATTTTGTGGTTAATAATTCTTGTTAATTTATTTTTATCTTGTGGCAATGAATCTAAAGA AAAATCAAATCTTGGTCTTAGATTAAGAGAATTGGAAATTTCAGGTGGTGGATCTGAATCTAAG ATTGAAGTTTATAAAGAATTTATTGAAAAAGAAGATAAGAATATTTTAAAGATAGTTAATTCCA TTGATAAGAAAGCCAGATTTTTTAATTTAATTGGTCTTGAATTTTTTAAGCTTGGTCAGTACGGA CCTGCTATTGAATATTTTGCTAAAAATTTAGAAATCAATCCCAATAATTATTTATCTCATTTTTA TATAGGTGTTGCTTCTTATAATTTAGCTAAAAATTTAAGAGTAAAAGATGAAGTTGAAAAATAC ATAATTCTTGCTGAAAATTCTTTTTTAAAATCACTTTCAATTAGAGATGATTTTAAAGATTCTCT TTTTGCCATTTCTAATATGTACGTATATGATCTTGATAAACAACTTGAAGCTAAAAATTATTTAA ATAAACTTGGTGATATGGGTGAGGACTATTTTGAGTTTTTAATGTTAAGAGGTGCAAATTATTA TTCGCTGGGCGATCTTGGTAATGCTATATTGTTTTATGATAAAGCTAGTAAAAAGGCTTCAACT GAAGAGCAAAAAGAAGGTGTTTCTAGGATCATGAGTAATTTGAAGTAA t635.nt (SEQ ID NO:452) TGTGGCAATGAATCTAAAGAAAAATCAAATCTTGGTCTTAGATTAAGAGAATTGGAAATTTCAG GTGGTGGATCTGAATCTAAGATTGAAGTTTATAAAGAATTTATTGAAAAAGAAGATAAGAATA TTTTAAAGATAGTTAATTCCATTGATAAGAAAGCCAGATTTTTTAATTTAATTGGTCTTGAATTT TTTAAGCTTGGTCAGTACGGACCTGCTATTGAATATTTTGCTAAAAATTTAGAAATCAATCCCA ATAATTATTTATCTCATTTTTATATAGGTGTTGCTTCTTATAATTTAGCTAAAAATTTAAGAGTA AAAGATGAAGTTGAAAAATACATAATTCTTGCTGAAAATTCTTTTTTAAAATCACTTTCAATTA GAGATGATTTTAAAGATTCTCTTTTTGCCATTTCTAATATGTACGTATATGATCTTGATAAACAA CTTGAAGCTAAAAATTATTTAAATAAACTTGGTGATATGGGTGAGGACTATTTTGAGTTTTTAA TGTTAAGAGGTGCAAATTATTATTCGCTGGGCGATCTTGGTAATGCTATATTGTTTTATGATAA AGCTAGTAAAAAGGCTTCAACTGAAGAGCAAAAAGAAGGTGTTTCTAGGATCATGAGTAATTT GAAGTAA f314.aa (SEQ ID NO:453) MNNCLIKFFIFLLVFSNSYVAFSKNVNVLIVTAMDSEFDQINKLMSNKEEIVLKEYGLNKKILKGKLS NRNVMVIICGVGKVNAGVWTSYILSKYNISHVINSGVAGGVVSAKYKDIKVGDVVVSSEVAYHDV DLTKFGYKVGQLTGGLPQKFNANKNLIKNAIEAIKSKVGGSNAYSGLIVSGDQFIDPTYINKIIGNFK DVIAVEMEGAAIGHVSHMFNIPFIVIRSISDIVNKEGNEVEYSKFSKIAAFNSAKVVQEILRKL t314.aa (SEQ ID NO:454) KNVNVLIVTAMDSEFDQINKLMSNKEEIVLKEYGLNKKILKGKLSNRNVMVIICGVGKVNAGVWTS YILSKYNISHVINSGVAGGVVSAKYKDIKVGDVVVSSEVAYHDVDLTKFGYKVGQLTGGLPQKFNA NKNLIKNAIEAIKSKVGGSNAYSGLIVSGDQFIDPTYINKIIGNFKDVIAVEMEGAAIGHVSHMFNIPFI VIRSISDIVNKEGNEVEYSKFSKIAAFNSAKVVQEILRKL f314.nt (SEQ ID NO:455) ATGAATAATTGTTTAATAAAGTTTTTTATTTTTTTATTAGTTTTTTCAAACAGTTATGTTGCTTTT TCTAAAAATGTCAATGTTTTAATAGTAACTGCTATGGACTCTGAGTTTGATCAGATAAATAAGC TTATGTCTAATAAGGAAGAAATAGTTCTTAAGGAGTATGGTCTTAATAAAAAGATTTTAAAGGG GAAGTTGTCTAATCGCAATGTTATGGTTATTATTTGTGGGGTTGGTAAGGTTAATGCTGGTGTG TGGACTAGCTACATTTTGTCAAAATACAACATAAGTCATGTCATTAATTCTGGCGTTGCTGGTG GCGTTGTTAGTGCTAAATACAAAGATATTAAAGTGGGAGATGTGGTGGTGTCTTCAGAGGTTGC ATATCATGATGTTGATTTGACTAAATTTGGATACAAGGTAGGACAGCTTACAGGAGGATTGCCT CAAAAATTTAATGCCAATAAAAATTTAATTAAGAATGCCATAGAGGCCATTAAATCAAAGGTTG GAGGTTCTAATGCATATTCAGGATTAATAGTTTCAGGAGATCAGTTTATTGATCCAACTTATAT TAACAAAATTATAGGAAACTTTAAAGATGTAATAGCTGTTGAGATGGAAGGTGCAGCAATAGG GCATGTTTCTCATATGTTTAATATACCTTTTATAGTTATTAGGTCAATATCTGACATTGTAAATA AAGAAGGGAATGAGGTTGAATATAGTAAATTTTCTAAAATAGCTGCTTTCAATTCAGCCAAAGT TGTACAAGAAATTTTAAGAAAACTTTAA t314.nt (SEQ ID NO:456) AAAAATGTCAATGTTTTAATAGTAACTGCTATGGACTCTGAGTTTGATCAGATAAATAAGCTTA TGTCTAATAAGGAAGAAATAGTTCTTAAGGAGTATGGTCTTAATAAAAAGATTTTAAAGGGGA AGTTGTCTAATCGCAATGTTATGGTTATTATTTGTGGGGTTGGTAAGGTTAATGCTGGTGTGTG GACTAGCTACATTTTGTCAAAATACAACATAAGTCATGTCATTAATTCTGGCGTTGCTGGTGGC GTTGTTAGTGCTAAATACAAAGATATTAAAGTGGGAGATGTGGTGGTGTCTTCAGAGGTTGCAT ATCATGATGTTGATTTGACTAAATTTGGATACAAGGTAGGACAGCTTACAGGAGGATTGCCTCA AAAATTTAATGCCAATAAAAATTTAATTAAGAATGCCATAGAGGCCATTAAATCAAAGGTTGGA GGTTCTAATGCATATTCAGGATTAATAGTTTCAGGAGATCAGTTTATTGATCCAACTTATATTAA CAAAATTATAGGAAACTTTAAAGATGTAATAGCTGTTGAGATGGAAGGTGCAGCAATAGGGCA TGTTTCTCATATGTTTAATATACCTTTTATAGTTATTAGGTCAATATCTGACATTGTAAATAAAG AAGGGAATGAGGTTGAATATAGTAAATTTTCTAAAATAGCTGCTTTCAATTCAGCCAAAGTTGT ACAAGAAATTTTAAGAAAACTTTAA f32.aa (SEQ ID NO:457) MNTKTLYLISLILLACNKNNKIPLIQKLDLPKSSILGFSNKMGIIIKDYAFLSKSTKKNSELDVDYAILL RKDEVVKIEKTLEKTERYGIEGNWILVNYKGTKRYIFSKDFNIVNNLIIDHSK t32.aa (SEQ ID NO:458) CNKNNKIPLIQKLDLPKSSILGFSNKMGIIIKDYAFLSKSTKKNSELDYDYAILLRKDEVVKIEKTLEK TERYGIEGNWILVNYKGTKRYIFSKDINIVNNLIIDHSK f32.nt (SEQ ID NO:459) ATGAATACAAAAACATTATATTTAATATCCTTAATTCTTTAGCTTGCAATAAAAATAA CAAAATTCCTCTCATTCAAAAATTAGATTTGCCCAAAAGCAGCATTCTTGGCTTTAGCAATAAA ATGGGCATAATAATAAAAGATTATGCTTTTCTTAGTAAAAGCACTAAGAAAAATAGCGAATTGG ATTATGATTACGCAATTCTACTCAGAAAAGACGAAGTCGTAAAAATTGAAAAAACACTAGAAA AAACAGAGCGCTATGGAATTGAAGGAAATTGGATCCTAGTCAATTACAAGGGAACTAAAAGAT ACATCTTTAGCAAAGACATCAATATAGTCAACAATTTAATAATTGATCATTCTAAATAG t32.nt (SEQ ID NO:460) TGCAATAAAAATAACAAAATTCCTCTCATTCAAAAATTAGATTTGCCCAAAAGCAGCATTCTTG GCTTTAGCAATAAAATGGGCATAATAATAAAAGATTATGCTTTTCTTAGTAAAAGCACTAAGAA AAATAGCGAATTGGATTATGATTACGCAATTCTACTCAGAAAAGACGAAGTCGTAAAAATTGA AAAAACACTAGAAAAAACAGAGCGCTATGGAATTGAAGGAAATTGGATCCTAGTCAATTACAA GGGAACTAAAAGATACATCTTTAGCAAAGACATCAATATAGTCAACAATTTAATAATTGATCAT TCTAAATAG f320.aa (SEQ ID NO:461) MKSIYALLFLFINLSLLANNISKKDLEVLLKIAQAMNKECKNFIEKNPIQFLKEIKPLVDAEKNNLLTL INKKIPIPENYKIPDLVNIDDFEDLKNLGAKTIKVRKILIEDLIRLIKDAKKFGIEIKIKSAYRTQEYQKF LFDYNVKTYGRKVAETQSAIPGHSQHHMGTAIDFINIDDNLLNTKEGKWLYENSLKYGFSVSYPKG YETDTGYAAEPWHYLYIGPKPCFIQKKYFNNLQHKLLEFWNQNKTNLINLIEKYAN t320.aa (SEQ ID NO:462) NNISKKDLEVLLKIAQAMNKECKNFIEKNPIQFLKEIKPLVDAEKNNLLTLINKKIPIPENYKIPDLVNI DDFEDLKNLGAKTIKVRKILIEDLIRLIKDAKKFGIEIKIKSAYRTQEYQKFLFDYNVKTYGRKVAET QSAIPGHSQHHMGTAIDFINIDDNLLNTKEGKWLYENSLKYGFSVSYPKGYETDTGYKAEPWHYLY IGPKPCFIQKKYFNNLQHKLLEFWNQNKTNLINLIEKYAN f320.nt (SEQ ID NO:463) ATGAAATCAATTTATGCTTTATTATTTCTATTTATTAATTTATCTTTGTTGGCTAACAACATTTCA AAAAAAGATTTAGAAGTACTGCTAAAGATTGCCCAAGCAATGAATAAGGAATGCAAAAATTTT ATTGAAAAAAATCCTATTCAGTTCTTAAAAGAAATAAAACCCTTAGTAGATGCAGAAAAAAATA ACCTCTTAACTCTAATAAATAAAAAAATACCAATTCCTGAAAATTATAAAATACCTGATCTGGT AAATATTGATGATTTTGAAGATCTTAAAAATCTTGGAGCAAAGACTATTAAAGTAAGAAAAATA TTAATCGAAGATTTAATTCGACTAATAAAAGATGCAAAAAAATTTGGGATTGAAATTAAAATCA AATCTGCTTACAGAACGCAAGAATATCAAAAATTTTTATTTGATTACAATGTCAAAACTTATGG CAGAAAAGTTGCAGAAACCCAATCAGCAATTCCAGGCCATTCTCAACATCATATGGGAACAGC AATAGATTTTATAAATATAGATGATAATTTACTAAACACAAAAGAAGGAAAATGGCTTTATGAA AACTCTCTAAAATACGGATTTTCCGTTTCATACCCAAAAGGATATGAAACGGACACTGGATATA AAGCAGAGCCTTGGCACTACTTATACATAGGACCTAAGCCATGCTTTATTCAGAAAAAATATTT TAATAATTTACAACATAAGCTTCTTGAATTTTGGAACCAGAACAAAACAAATCTTATTAACCTA ATTGAAAAATATGCAAACTAA f320.nt (SEQ ID NO:464) AACAACATTTCAAAAAAAGATTTAGAAGTACTGCTAAAGATTGCCCAAGCAATGAATAAGGAA TGCAAAAATTTTATTGAAAAAAATCCTATTCAGTTCTTAAAAGAAATAAAACCCTTAGTAGATG CAGAAAAAAATAACCTCTTAACTCTAATAAATAAAAAAATACCAATTCCTGAAAATTATAAAAT ACCTGATCTGGTAAATATTGATGATTTTGAAGATCTTAAAAATCTTGGAGCAAAGACTATTAAA GTAAGAAAAATATTAATCGAAGATTTAATTCGACTAATAAAAGATGCAAAAAAATTTGGGATT GAAATTAAAATCAAATCTGCTTACAGAACGCAAGAATATCAAAAATTTTTATTTGATTACAATG TCAAAACTTATGGCAGAAAAGTTGCAGAAACCCAATCAGCAATTCCAGGCCATTCTCAACATCA TATGGGAACAGCAATAGATTTTATAAATATAGATGATAATTTACTAAACACAAAAGAAGGAAA ATGGCTTTATGAAAACTCTCTAAAATACGGATTTTCCGTTTCATACCCAAAAGGATATGAAACG GACACTGGATATAAAGCAGAGCCTTGGCACTACTTATACATAGGACCTAAGCCATGCTTTATTC AGAAAAAATATTTTAATAATTTACAACATAAGCTTCTTGAATTTTGGAACCAGAACAAAACAAA TCTTATTAACCTAATTGAAAAATATGCAAACTAA f342.aa (SEQ ID NO:465) MLYLGDNKAMRTKIIIMTIIILLAPISGFSNSKESARGKFGAGIILPLPIALQINIGNFDLDIGLYSGVNN LFSDWKTLFIALDYIFYIYTFPGAANILDFSVGAGGYGTIWFSRFGGSKSGSGPMSIGARLPLALNIAV FRKKFDIFLRIAPGLGMNVWSNGVGFRWEVFAGLGLRFWFT t342.aa (SEQ ID NO:466) LAPISGFSNSKESARGKFGAGIILPLPIALQINIGNFDLDIGLYSGVNNLFSDWKTLFIALDYIFYIYTFP GAANILDFSVGAGGYGTIWFSRFGGSKSGSGPMSIGARLPLALNIAVFRKKFDIFLRIAPGLGMNVWS NGVGFRWEVFAGLGLRFWFT f342.nt (SEQ ID NO:467) ATGCTATACTTAGGAGATAATAAAGCAATGAGAACAAAAATAATTATTATGACAATTATTATTT TATTAGCCCCAATCTCAGGATTTTCTAATTCAAAAGAATCTGCAAGGGGTAAATTTGGAGCAGG AATTATACTTCCATTACCAATTGCTCTACAGATTAATATAGGAAACTTTGATCTTGACATTGGTC TTTACAGCGGAGTAAATAATTTGTTTTCAGACTGGAAAACATTATTTATAGCATTAGACTATAT TTTCTACATATACACATTCCCGGGAGCTGCTAATATTTTGGATTTTTCAGTTGGCGCAGGGGGA TATGGAACAATATGGTTTTCAAGATTTGGAGGCAGTAAGTCAGGCTCAGGACCAATGAGCATTG GAGCAAGATTGCCTTTGGCCTTAAATATTGCAGTATTTAGGAAGAAATTCGACATATTTTTACG AATAGCACCCGGACTTGGAATGAATGTTTGGAGTAATGGCGTTGGATTTAGATGGGAAGTATTC GCAGGATTGGGACTAAGATTCTGGTTTACTTAA t342.nt (SEQ ID NO:468) TTAGCCCCAATCTCAGGATTTTCTAATTCAAAAGAATCTGCAAGGGGTAAATTTGGAGCAGGAA TTATACTTCCATTACCAATTGCTCTACAGATTAATATAGGAAACTTTGATCTTGACATTGGTCTT TACAGCGGAGTAAATAATTTGTTTTCAGACTGGAAAACATTATTTATAGCATTAGACTATATTT TCTACATATACACATTCCCGGGAGCTGCTAATATTTTGGATTTTTCAGTTGGCGCAGGGGGATA TGGAACAATATGGTTTTCAAGATTTGGAGGCAGTAAGTCAGGCTCAGGACCAATGAGCATTGG AGCAAGATTGCCTTTGGCCTTAAATATTGCAGTATTTAGGAAGAAATTCGACATATTTTTACGA ATAGCACCCGGACTTGGAATGAATGTTTGGAGTAATGGCGTTGGATTTAGATGGGAAGTATTCG CAGGATTGGGACTAAGATTCTGGTTTACTTAA f352.aa (SEQ ID NO:469) MNKTKNRSLTYFIILSCISLFGANNNTISYSSIEIPLEDLSEEFKSSGNKSDQINTSKHLNKNIVSYEDPK KGKDLKLPENIRDKKLPQKRMDENDLKSVIENYENKIKNIEKLLKTKNQKTSENENKKIESIEKKAK KYEILTNKLKNEIVELKKLLNKKIKPKEDENYEKINIENIEEETDDDFEDNYEYNDEIEEQMRTITLLM KE t352.aa (SEQ ID NO:470) CISLFGANNNTISYSSIEIPLEDLSEEFKSSGNKSDQINTSKHLNKNIVSYEDPKKGKDLKLPENIRDKK LPQKRMDENDLKSVIENYENKIKNIEKLLKTKNQKTSENENKKIESIEKKAKKYEILTNKLKNEIVEI KKLLNKKIKPKEDENYEKINIENIEEETDDDFEDNYEYNDEIEEQMRTITLLMKE f352.nt (SEQ ID NO:471) ATGAATAAAACAAAAAATCGAAGCCTTACGTATTTTATAATACTTTCATGTATATCATTATTTG GGGCTAATAATAATACAATAAGCTACTCTAGCATTGAAATTCCTCTAGAAGACTTAAGTGAAGA ATTTAAAAGTTCTGGGAATAAAAGCGATCAAATAAATACCTCAAAACATTTAAACAAAAACAT AGTTTCTTATGAAGACCCAAAAAAGGGTAAAGATCTAAAATTGCCAGAAAATATAAGAGACAA AAAACTACCCCAAAAAAGAATGGACGAAAATGATCTAAAATCTGTAATTGAAAATTATGAAAA TAAAATTAAAAACATAGAAAAGCTTTTAAAAACCAAAAATCAAAAAACATCGGAAAATGAAAA TAAAAAAATAGAATCAATCGAAAAAAAAGCAAAAAAATATGAAATTTTAACCAATAAATTAAA AAACGAAATAGTAGAAATAAAAAAGCTCCTTAACAAAAAAATCAAGCCTAAAGAAGATGAAAA TTACGAAAAAATAAATATTGAAAACATTGAAGAAGAAACTGATGATGATTTTGAAGACAATTA TGAATATAATGATGAAATTGAAGAACAAATGAGGACAATTACCCTTCTAATGAAGGAATAA t352.nt (SEQ ID NO:472) TGTATATCATTATTTGGGGCTAATAATAATACAATAAGCTACTCTAGCATTGAAATTCCTCTAG AAGACTTAAGTGAAGAATTTAAAAGTTCTGGGAATAAAAGCGATCAAATAAATACCTCAAAAC ATTTAAACAAAAACATAGTTTCTTATGAAGACCCAAAAAAGGGTAAAGATCTAAAATTGCCAG AAAATATAAGAGACAAAAAACTACCCCAAAAAAGAATGGACGAAAATGATCTAAAATCTGTAA TTGAAAATTATGAAAATAAAATTAAAAACATAGAAAAGCTTTTAAAAACCAAAAATCAAAAAA CATCGGAAAATGAAAATAAAAAAATAGAATCAATCGAAAAAAAAGCAAAAAAATATGAAATTT TAACCAATAAATTAAAAAACGAAATAGTAGAAATAAAAAAGCTCCTTAACAAAAAAATCAAGC CTAAAGAAGATGAAAATTACGAAAAAATAAATATTGAAAACATTGAAGAAGAAACTGATGATG ATTTTGAAGACAATTATGAATATAATGATGAAATTGAAGAACAAATGAGGACAATTACCCTTCT AATGAAGGAATAA f301.aa (SEQ ID NO:473) MQIDGKIYSIISFPVRDSVSTLGVIGILICFDESLDIIENQLYSSLKFGSKNYNFFMLDRNYMPIFSNLNN LQAKSFSTAYSENFLSKVIAYAKKDSSSSQYTFNYERDFYSLNFVKTDDFLTQGLILNVNSIPIMFKS NWVIFVAFLLLSFAIIFYLCNTFVFSLINDFNRIVDYQKSKSDPFSLESPLEVKYSSSIISYISSKLDNLSS KSNESFEKIKFYSEDLNEYLEQIETAISNTESIDSSILVYEQLRDTFSRFEKSIVDILKGFESIADPINDHN KYISEISSNFEESVSFFYSIDKNLEIFNKVATINSTDIENIKSKVFDLNIVFENVKNFADLLSQTNSLQS VNKLLVSISAQTNMLAMNAAIEAAKAGDAGKSFAVVAEEIRKLAINSGKYSKTIKDELKTVDSIIAVI NSEIDTIYKNFIDIQDNVDNNFSRHEKVDLTLAKHFKEIGEFKERYLSHDTKIRDAKNMYKEIFNNHY FISGKFNNFSQDLKEFKVSKMNLDAVSSLQEYSSLVKSSKDKILKTKELIQKINDEIKDILF t301.aa (SEQ ID NO:474) CFDESLDIIENQLYSSLKFGSKNYNFFMLDRNYMPIFSNLNNLQAKSFSTAYSENFLSKVIAYAKKDS SSSQYTFNYERDFYSLNFVKTDDFLTQGLILNVNSIPIMFKSNWVIFVAFLLLSFAIIFYLCNTFVFSLI NDFNRIVDYQKSKSDPFSLESPLEVKYSSSIISYISSKLDNLSSKSNESFEKIKFYSEDLNEYLEQIETAI SNTESIDSSILVYEQLRDTFSRFEKSIVDILKGFESIADPINDHNKYISEISSNFEESVSFFYSIDKNLEIFN KVATINSTDIENIKSKVFDLNIVFENVNKNFADLLSQTNSLQSVNKLLVSISAQTNMLAMNAAIEAAK AGDAGKSFAVVAEEIRKLAINSGKYSKTIKDELKTVDSIIAVINSEIDTIYKNFIDIQDNVDNNFSRHE KVDLTLAKHFKEIGEFKERYLSHDTKIRDAKNMYKEIFNNHYFISGKFNNFSQDLKEFKVSKMNLD AVSSLQEYSSLVKSSKDKILKTKELIQKINDEIKDILF f301.nt (SEQ ID NO:475) ATGCAAATAGATGGGAAAATTTATTCTATAATAAGTTTTCCAGTTAGAGATTCTGTTTCAACAT TGGGTGTGATAGGGATTTTAATATGCTTTGATGAGTCGTTAGATATTATTGAAAATCAGTTGTA TTCTTCTCTTAAATTTGGTAGTAAAAATTATAATTTTTTTATGCTTGACAGAAATTACATGCCCA TTTTTTCAAACCTTAATAATCTTCAGGCCAAATCTTTTTCTACAGCTTATAGTGAGAATTTTTTG AGTAAAGTTATAGCTTATGCTAAAAAAGATTCTTCTAGCTCTCAGTACACTTTTAATTATGAAA GAGATTTTTATTCTTTAAACTTTGTAAAAACCGATGATTTTTTGACTCAGGGGCTTATTTTAAAT GTCAATTCCATTCCTATTATGTTTAAATCAAATTGGGTTATATTTGTTGCATTTTTATTATTGTCT TTTGCAATTATTTTTTATTTATGCAATACTTTTGTTTTTTCATTAATTAATGATTTTAACAGAATT GTTGACTATCAAAAATCAAAAAGCGATCCTTTTAGTCTTGAATCTCCCTTAGAGGTTAAGTATT CTTCATCTATTATTTCTTATATTAGTTCAAAGCTAGATAATCTGTCTTCTAAGAGTAATGAATCT TTTGAGAAGATAAAATTTTATTCTGAAGATTTGAATGAATATTTGGAACAAATAGAAACTGCTA TATCAAATACTGAGAGTATAGATTCTAGCATTTTAGTTTACGAACAACTAAGAGATACTTTTTC TAGATTTGAAAAATCAATTGTTGATATTTTAAAAGGCTTTGAATCTATTGCTGATCCGATTAAT GATCACAATAAATATATATCAGAAATCTCTTCAAATTTTGAAGAGAGTGTTAGTTTTTTCTATA GTATAGATAAAAATTTAGAAATTTTTAATAAGGTTGCTACTATAAATTCTACTGATATTGAAAA TATTAAAAGTAAGGTTTTTGATTTAAATATTGTTTTTGAAAATGTGAATAAAAATTTTGCAGAT CTTTTGTCTCAAACAAATAGTTTGCAAAGTGTAAATAAACTTTTAGTTTCAATTTCAGCTCAGAC CAATATGCTTGCTATGAATGCAGCAATTGAAGCAGCAAAAGCAGGTGATGCAGGTAAAAGTTT TGCAGTTGTTGCTGAGGAGATTAGAAAGCTTGCTATTAATTCTGGAAAATATTCTAAAACCATT AAAGATGAACTTAAAACGGTCGACAGCATTATTGCAGTAATTAATTCAGAGATTGATACAATTT ATAAAAATTTCATAGACATTCAAGATAATGTGGACAACAATTTTTCAAGACACGAGAAAGTAG ATCTTACTCTTGCTAAGCATTTTAAAGAAATTGGCGAGTTTAAAGAAAGGTATTTGTCTCACGA TACTAAGATCAGAGATGCTAAGAATATGTATAAAGAAATATTTAATAATCATTATTTTATTAGT GGCAAGTTTAACAACTTTAGTCAAGATTTAAAAGAGTTTAAAGTTTCTAAGATGAATTTAGATG CGGTAAGTTCTCTTCAAGAATATTCATCTTTAGTAAAGTCTTCTAAGGATAAGATATTAAAGAC AAAGGAATTGATTCAAAAGATTAATGATGAGATTAAAGATATTCTTTTTTAG t301.nt (SEQ ID NO:476) TGCTTTGATGAGTCGTTAGATATTATTGAAAATCAGTTGTATTCTTCTCTTAAATTTGGTAGTAA AAATTATAATTTTTTTATGCTTGACAGAAATTACATGCCCATTTTTTCAAACCTTAATAATCTTC AGGCCAAATCTTTTTCTACAGCTTATAGTGAGAATTTTTTGAGTAAAGTTATAGCTTATGCTAAA AAAGATTCTTCTAGCTCTCAGTACACTTTTAATTATGAAAGAGATTTTTATTCTTTAAACTTTGT AAAAACCGATGATTTTTTGACTCAGGGGCTTATTTTAAATGTCAATTCCATTCCTATTATGTTTA AATCAAATTGGGTTATATTTGTTGCATTTTTATTATTGTCTTTTGCAATTATTTTTTATTTATGCA ATACTTTTGTTTTTTCATTAATTAATGATTTTAACAGAATTGTTGACTATCAAAAATCAAAAAGC GATCCTTTTAGTCTTGAATCTCCCTTAGAGGTTAAGTATTCTTCATCTATTATTTCTTATATTAGT TCAAAGCTAGATAATCTGTCTTCTAAGAGTAATGAATCTTTTGAGAAGATAAAATTTTATTCTG AAGATTTGAATGAATATTTGGAACAAATAGAAACTGCTATATCAAATACTGAGAGTATAGATTC TAGCATTTTAGTTTACGAACAACTAAGAGATACTTTTTCTAGATTTGAAAAATCAATTGTTGAT ATTTTAAAAGGCTTTGAATCTATTGCTGATCCGATTAATGATCACAATAAATATATATCAGAAA TCTCTTCAAATTTTGAAGAGAGTGTTAGTTTTTTCTATAGTATAGATAAAAATTTAGAAATTTTT AATAAGGTTGCTACTATAAATTCTACTGATATTGAAAATATTAAAAGTAAGGTTTTTGATTTAA ATATTGTTTTTGAAAATGTGAATAAAAATTTTGCAGATCTTTTGTCTCAAACAAATAGTTTGCAA AGCTTGTAAATAAACTTTTAGTTTCAATTTCAGCTCAGACCAATATGCTTGCTATGAATGCAGCAA TTGAAGCAGCAAAAGCAGGTGATGCAGGTAAAAGTTTTGCAGTTGTTGCTGAGGAGATTAGAA AGTGCTATTAATTCTGGAAAATATTCTAAAACCATTAAAGATGAACTTAAAACGGTCGACAG CATTATTGCAGTAATTAATTCAGAGATTGATACAATTTATAAAAATTTCATAGACATTCAAGAT AATGTGGACAACAATTTTTCAAGACACGAGAAAGTAGATCTTACTCTTGCTAAGCATTTTAAAG AAATTGGCGAGTTTAAAGAAAGGTATTTGTCTCACGATACTAAGATCAGAGATGCTAAGAATAT GTATAAAGAAATATTTAATAATCATTATTTTATTAGTGGCAAGTTTAACAACTTTAGTCAAGAT TTAAAAGAGTTTAAAGTTTCTAAGATGAATTTAGATGCGGTAAGTTCTCTTCAAGAATATTCAT CTTTAGTAAAGTCTTCTAAGGATAAGATATTAAAGACAAAGGAATTGATTCAAAAGATTAATGA TGAGATTAAAGATATTCTTTTTTAG f346.aa (SEQ ID NO:477) MSIDKVPDEAFAEKIVGDGIAILPTSNELLAPCDGKIGKIFKTNHAFSLETKEGVEIFVHFGIN TLNLNGKGFTRVAEEGINVKQGEVIIRLDLEYLKEHSESVITPVVIANSDEVSSIEYSFGRLENDSEYIL SSSTVLTEEIRHKISQTKPVIAGKDLVLRVKK t346.aa (SEQ ID NO:478) CDGKIGKIFKTNHAFSLETKEGVEIFVHFGINTLNLNGKGFTRVAEEGINVKQGEVIIRLDLEYLKEHS ESVITPVVIANSDEVSSIEYSFGRLENDSEYILSSSTVLTEEIRHKISQTKPVIAGKDLVLRVKK f346.nt (SEQ ID NO:479) ATGTCAATTGATAAGGTTCCCGATGAAGCTTTTGCTGAAAAAATAGTTGGCGATGGAATTGCAA TTCTTCCAACAAGCAATGAGTTGTTGGCGCCTTGTGATGGGAAAATAGGTAAAATTTTTAAAAC CAATCATGCCTTTAGCCTTGAAACTAAAGAGGGCGTTGAAATTTTTGTCCATTTTGGAATTAAT ACTCTTAATTTAAATGGTAAGGGTTTTACAAGAGTTGCTGAAGAGGGCATTAATGTTAAACAAG GTGAAGTTATTATTAGGCTTGATCTTGAATATTTAAAAGAGCATTCAGAATCCGTTATTACTCC GGTTGTTATTGCAAATTCTGATGAAGTTTCAAGTATAGAATATTCTTTTGGAAGGCTTGAAAAT GATTCTGAATATATTTTATCATCTTCAACTGTCTTGACAGAAGAAATTAGGCATAAAATATCTC AAACAAAGCCTGTTATAGCGGGCAAAGATTTGGTGTTGCGAGTTAAAAAGTAA t346.nt (SEQ ID NO:480) TGTGATGGGAAAATAGGTAAAATTTTTAAAACCAATCATGCCTTTAGCCTTGAAACTAAAGAGG GCGTTGAAATTTTTGTCCATTTTGGAATTAATACTCTTAATTTAAATGGTAAGGGTTTTACAAGA GTTGCTGAAGAGGGCATTAATGTTAAACAAGGTGAAGTTATTATTAGGCTTGATCTTGAATATT TAAAAGAGCATTCAGAATCCGTTATTACTCCGGTTGTTATTGCAAATTCTGATGAAGTTTCAAG TATAGAATATTCTGGAAGGCTTGAAAATGATTCTGAATATATTTTATCATCTTCAACTGTCT TGACAGAAGAAATTAGGCATAAAATATCTCAAACAAAGCCTGTTATAGCGGGCAAAGATTTGG TGTTGCGAGTTAAAAAGTAA f373.aa (SEQ ID NO:481) MNYQRIKNYCKFTSVFLFFLFSCVSNELKLDQSLVKGKLVNGLRYYIYKNQTPKNAVNMGIVFNVG SLNEEDNERGIAHYLEHMAFNGTKDYPGNSIVDVLKKFGMQFGADINAATSFDFTYYRLDLSDGNN KDEIDESINILRNWASQISFMKEEIDLERNIIIEEKKLGETYPGRIYEKMDKFLTSGSLYEFRSPIGLEEQ ILSFQPEDFKKFYRKWYRPELASVIVVGDIDPIEIEEKIKKQFVSWKNPTDKIKEVKVSLDVELKDKF LLLEDLEVGEPSLMFFKKEIINFVKTKDDLLNAIKKSLLAALFENRFSELKTAGVKQFKNVSNKDFFS FKSDNNTIVAKSISLNFNPDHLNEGIQDFFYELERIRKFGFTQGELEKVRSQFYKSLELRKKNINKTNS WAIFQDLIEIAINGSNKFDMNEYCDLSFQYLEKIDLKTINNLVGREFDVKNCAIFYSYHGRAHPVLTL EDIDNLQKIALKRELKPYENSLIEGKFFKKSLDDKDIIRENEFENEISSFVLENGVEVYFKYNDQKKG VIDFSATSWGGLINEDLKLIPVLSFAPGVVSGSGYGDYSALQIEKYLSDKAVSLRVGVGAQESYISGS SDKKDLETLFQLIYFTFKEPKIDDVSLQNAINNIKALIKSNENSSDYHFHKAISKFLNNNDPRFEDTKD SDLQYFTKENILSFYKKRFTYANNFKFVLLETQIFRQ t373.aa (SEQ ID NO:482) CVSNELKLDQSLVKGKLVNGLRYYIYKNQTPKNAVNMGIVFNVGSLNEEDNERGIAHYLE RMAFNGTKDYPGNSIVDVLKKFGMQFGADINAATSFDFTYYRLDLSDGNNKDEIDESINILRNWAS QISFMKEEIDLERNIIIEEKKLGETYPGRIYEKMDKFLTSGSLYEFRSPIGLEEQILSFQPEDFKKFYRK WYRPELASVIVVGDIDPIEIEEKIKKQFVSWKNPTDKIKEVKVSLDVELKDKFLLLEDLEVGEPSLMF FKKEIINFVKTKDDLLNAIKKSLLAALFENRFSELKTAGVKQFKNVSNKDFFSFKSDNNTIVAKSISLN FNPDHLNEGIQDFFYELERIRKFGFTQGELEKVRSQFYKSLELRKKNINKTNSWAIFQDLIEIAINGSN KFDMNEYCDLSFQYLEKIDLKTINNLVGREFDVKNCAIFYSYHGRAHPVLTLEDIDNLQKIALKREL KPYENSLIEGKFFKKSLDDKDIIRENEFENEISSFVLENGVEVYFKYNDQKKGVIDFSATSWGGLINE DLKLIPVLSFAPGVVSGSGYGDYSALQIEKYLSDKAVSLRVGVGAQESYISGSSDKKDLETLFQLIYF TFKEPKTDDVSLQNAINNIKALIKSNENSSDYHFHKAISKFLNNNDPRFEDTKDSDLQYFTKENILSFY KKRFTYANNFKFVLLETQIFRQ f373.nt (SEQ ID NO:483) ATGAATTATCAAAGAATTAAGAATTATTGTAAATTTACAAGCGTTTTTCTATTTTTTTTG TTTTCCTGTGTTTCTAATGAGTTAAAGTTAGATCAAAGTTTGGTAAAAGGAAAACTTGTCAATG GGCTAAGGTATTATATTTATAAAAATCAAACCCCAAAGAATGCCGTTAATATGGGAATTGTTTT TAATGTGGGCTCACTTAATGAAGAAGATAATGAGAGGGGAATAGCGCATTATCTTGAACATAT GGCTTTTAATGGTACAAAAGATTATCCAGGGAATTCTATAGTTGATGTTCTTAAAAAATTTGGA ATGCAATTTGGTGCTGACATTAATGCTGCTACTAGTTTTGATTTCACTTATTATAGACTTGATTT GTCAGATGGTAATAATAAAGATGAAATTGATGAATCTATAAATATTTTGAGAAACTGGGCTTCT CAAATCAGTTTCATGAAAGAAGAAATAGATCTAGAGCGAAATATTATTATTGAGGAAAAAAAG CTTGGTGAGACTTATCCTGGAAGAATTTATGAGAAAATGGATAAGTTTTTGACAAGCGGAAGTC TTTATGAATTTAGAAGTCCTATTGGACTTGAAGAGCAAATTTTATCTTTTCAGCCAGAAGATTTT AAAAAATTTTATAGAAAGTGGTATAGGCCAGAACTTGCAAGTGTTATTGTGGTAGGAGATATTG ATCCTATAGAAATTGAAGAGAAGATAAAGAAGCAATTTGTTTCTTGGAAAAATCCAACCGATA AAATTAAAGAAGTAAAAGTAAGTTTAGACGTAGAGCTTAAGGATAAATTTTTACTTTTAGAAGA TTTGGAAGTTGGAGAGCCTACTTTAATGTTCTTTAAAAAGGAAATTATTAACTTTGTAAAGACC AAAGATGACCTTTTAAATGCTATTAAAAAGTCTTTATTAGCCGCTCTTTTTGAAAATAGATTTTC TGAATTAAAGACTGCTGGGGTAAAGCAATTTAAAAATGTTTCAAATAAAGATTTTTTCTCATTT AAATCAGATAACAATACCATTGTTGCAAAATCGATTTCTTTAAACTTTAATCCAGATCATTTGA ACGAAGGAATACAAGACTTTTTTTATGAGCTTGAGAGGATAAGAAAATTTGGATTTACCCAAGG TGAGCTTGAAAAAGTTAGATCTCAATTTTACAAATCTTTAGAATTAAGGAAAAAGAATATAAAT AAAACAAATTCATGGGCTATTTTTCAGGATTTAATAGAAATTGCTATTAATGGTTCTAATAAAT TTGATATGAATGAATATTGCGATCTTTCTTTTCAATATTTGGAAAAGATTGATTTAAAAACAAT AAACAATCTTGTAGGAAGAGAGTTTGATGTAAAAAATTGTGCAATTTTTTATTCTTACCATGGA AGAGCACATCCTGTTTTAACTCTTGAAGATATTGACAATCTTCAAAAGATAGCTTTAAAAAGAG AGTTAAAGCCTTATGAGAATTCTTTAATTGAAGGTAAATTTTTTAAGAAGTCTTTAGATGATAA AGATATTATTAGAGAAAATGAGTTTGAAAATGAAATTTCGTCATTTGTTCTTGAAAATGGGGTT GAAGTTTATTTTAAATATAATGATCAAAAAAAAGGTGTAATTGATTTTAGTGCAACTTCTTGGG GAGGTTTAATTAATGAAGATTTAAAACTTATTCCTGTTTTATCTTTTGCTCCCGGAGTAGTATCT GGTTCGGGTTATGGTGATTATTCTGCATTACAGATTGAAAAATATTTATCAGATAAAGCTGTTT CTTTAAGAGTTGGGGTTGGAGCTCAAGAATCATATATTTCTGGAAGTTCAGATAAAAAAGATCT TGAAACTCTTTTTCAGCTTATATATTTTACTTTTAAGGAACCCAAAATTGATGATGTTTCTTTGC AAAATGCTATTAATAATATAAAAGCATTAATAAAGAGCAATGAAAATAGTTCTGATTATCATTT TCATAAAGCCATTAGTAAATTTTTAAACAATAATGATCCTAGATTTGAAGATACAAAAGATAGT GATTTGCAATATTTTACAAAAGAAAATATTTTGTCTTTTTATAAGAAAAGGTTTACTTATGCAA ATAATTTTAAGTTTGTCTTGCTGGAGACTCAGATATTCAGACAATAA t373.nt (SEQ ID NO:484) TGTGTTTCTAATGAGTTAAAGTTAGATCAAAGTTTGGTAAAAGGAAAACTTGTCAATGGGCTAA GGTATTATATTTATAAAAATCAAACCCCAAAGAATGCCGTTAATATGGGAATTGTTTTTAATGT GGGCTCACTTAATGAAGAAGATAATGAGAGGGGAATAGCGCATTATCTTGAACATATGGCTTTT AATGGTACAAAAGATTATCCAGGGAATTCTATAGTTGATGTTCTTAAAAAATTTGGAATGCAAT TTGGTGCTGACATTAATGCTGCTACTAGTTTTGATTTCACTTATTATAGACTTGATTTGTCAGAT GGTAATAATAAAGATGAAATTGATGAATCTATAAATATTTTGAGAAACTGGGCTTCTCAAATCA GTTTCATGAAAGAAGAAATAGATCTAGAGCGAAATATTATTATTGAGGAAAAAAAGCTTGGTG AGACTTATCCTGGAAGAATTTATGAGAAAATGGATAAGTTTTTGACAAGCGGAAGTCTTTATGA ATTTAGAAGTCCTATTGGACTTGAAGAGCAAATTTTATCTTTTCAGCCAGAAGATTTTAAAAAA TTTTATAGAAAGTGGTATAGGCCAGAACTTGCAAGTGTTATTGTGGTAGGAGATATTGATCCTA TAGAAATTGAAGAGAAGATAAAGAAGCAATTTGTTTCTTGGAAAAATCCAACCGATAAAATTA AAGAAGTAAAAGTAAGTTTAGACGTAGAGCTTAAGGATAAATTTTTACTTTTAGAAGATTTGGA AGTTGGAGAGCCTAGTTTAATGTTCTTTAAAAAGGAAATTATTAACTTTGTAAAGACCAAAGAT GACCTTTTAAATGCTATTAAAAAGTCTTTATTAGCCGCTCTTTTTGAAAATAGATTTTCTGAATT AAAGACTGCTGGGGTAAAGCAATTTAAAAATGTTTCAAATAAAGATTTTTTCTCATTTAAATCA GATAACAATACCATTGTTGCAAAATCGATTTCTTTAAACTTTAATCCAGATCATTTGAACGAAG GAATACAAGACTTTTTTTATGAGCTTGAGAGGATAAGAAAATTTGGATTTACCCAAGGTGAGCT TGAAAAAGTTAGATCTCAATTTTACAAATCTTTAGAATTAAGGAAAAAGAATATAAATAAAACA AATTCATGGGCTATTTTTCAGGATTTAATAGAAATTGCTATTAATGGTTCTAATAAATTTGATAT GAATGAATATTGCGATCTTTCTTTTCAATATTTGGAAAAGATTGATTTAAAAACAATAAACAAT CTTGTAGGAAGAGAGTTTGATGTAAAAAATTGTGCAATTTTTTATTCTTACCATGGAAGAGCAC ATCCTGTTTTAACTCTTGAAGATATTGACAATCTTCAAAAGATAGCTTTAAAAAGAGAGTTAAA GCCTTATGAGAATTCTTTAATTGAAGGTAAATTTTTTAAGAAGTCTTTAGATGATAAAGATATT ATTAGAGAAAATGAGTTTGAAAATGAAATTTCGTCATTTGTTCTTGAAAATGGGGTTGAAGTTT ATTTTAAATATAATGATCAAAAAAAAGGTGTAATTGATTTTAGTGCAACTTCTTGGGGAGGTTT AATTAATGAAGATTTAAAACTTATTCCTGTTTTATCTTTTGCTCCCGGAGTAGTATCTGGTTCGG GTTATGGTGATTATTCTGCATTACAGATTGAAAAATATTTATCAGATAAAGCTGTTTCTTTAAG AGTTGGGGTTGGAGCTCAAGAATCATATATTTCTGGAAGTTCAGATAAAAAAGATCTTGAAACT CTTTTTCAGCTTATATATTTTACTTTTAAGGAACCCAAAATTGATGATGTTTCTTTGCAAAATGC TATTAATAATATAAAAGCATTAATAAAGAGCAATGAAAATAGTTCTGATTATCATTTTCATAAA GCCATTAGTAAATTTTTAAACAATAATGATCCTAGATTTGAAGATACAAAAGATAGTGATTTGC AATATTTTACAAAAGAAAATATTTTGTCTTTTTATAAGAAAAGGTTTACTTATGCAAATAATTTT AAGTTTGTCTTGCTGGAGACTCAGATATTCAGACAATAA t384.aa (SEQ ID NO:485) MDWDFEKIIFLLNESTRLALSGCAKLILDFKSDGSIVTQVDKQIEQFLFKEIKKPGNFVLGEETISTYK EEYIKDALISESTFIIDPIDGTSSFAAGLPSYGISLAYASGGKIIEGAISLPLSGEFFITSKDNVFYAKKNI GSYPLKKDFNKFIFDNSKCYNIHSLLAVSRSIIRLFNLDISSHIHINGSCVYSFAKLFTGSYKAYFSFVG LWDIAACLAIGNKLGMVGEFYCGNKMTLDILDSMYILEPNNHKRWSLKDFFIYSDNKSTIDIIRKDA NKKINK t384.aa (SEQ ID NO:486) CAKLILDFKSDGSIVTQVDKQIEQFLFKEIKKPGNFVLGEETISTKKEEYIKDALISESTFIIDPIDGTSSF AAGLPSYGISLAYASGGKIIEGAISLPLSGEFFITSKDNVFYAKKNIGSYPLKKDFNKFIFDNSKCYNIH SLLAVSRSIIRLFNLDISSHIHINGSCVYSFAKLFTGSYKAYFSFVGLWDIAACLAIGNKLGMVGEFYC GNKMTLDILDSMYILEPNNHKRWSLKDFFIYSDNKSTIDIIRKDANKKINK f384.nt (SEQ ID NO:487) ATGGATTGGGATTTTGAAAAAATTATATTTTTATTAAATGAATCAACTAGGCTTGCATTAAGTG GTTGTGCTAAATTAATTTTAGATTTTAAATCTGATGGGTCTATTGTAACTCAGGTTGATAAGCA AATTGAGCAATTCTTATTCAAAGAGATCAAAAAGCCTGGAAATTTTGTTCTTGGAGAAGAGACA ATATCTACTTATAAAGAAGAGTATATCAAAGATGCTTTAATATCAGAGAGTACTTTTATTATTG ATCCTATTGATGGAACTTCTTCTTTTGCAGCAGGCCTTCCTTCATATGGAATATCGCTAGCGTAT GCTAGTGGCGGCAAAATTATTGAAGGAGCCATTTCTCTTCCTTTAAGCGGAGAGTTTTTTATTA CTTCTAAAGATAATGTATTTTATGCTAAAAAAAACATTGGTAGCTATCCTTTAAAAAAGGATTT TAATAAATTTATTTTTGATAATTCTAAATGTTACAATATTCATAGTTTACTTGCAGTTTCAAGGT CTATTATAAGGTTATTTAATCTTGATATTTCTTCTCATATTCATATTAATGGTTCTTGTGTATATT CTTTTGCTAAACTTTTTACAGGTTCTTATAAGGCCTACTTTTCTTTTGTAGGACTTTGGGATATT GCAGCGTGTTTAGCTATTGGTAATAAATTGGGCATGGTTGGCGAATTTTATTGTGGTAATAAAA TGACATTAGATATCTTAGATTCAATGTATATTTTAGAGCCTAATAATCATAAAAGATGGTCCTT GAAAGATTTTTTTATTTATTCTGATAATAAATCAACAATAGACATTATAAGAAAAGATGCAAAT AAAAAAATCAATAAGTAA t384.nt (SEQ ID NO:488) AGTGGTTGTGCTAAATTAATTTTAGATTTTAAATCTGATGGGTCTATTGTAACTCAGGTTGATA AGCAAATTGAGCAATTCTTATTCAAAGAGATCAAAAAGCCTGGAAATTTTGTTCTTGGAGAAGA GACAATATCTACTTATAAAGAAGAGTATATCAAAGATGCTTTAATATCAGAGAGTACTTTTATT ATTGATCCTATTGATGGAACTTCTTCTTTTGCAGCAGGCCTTCCTTCATATGGAATATCGCTAGC GTATGCTAGTGGCGGCAAAATTATTGAAGGAGCCATTTCTCTTCCTTTAAGCGGAGAGTTTTTT ATTACTTCTAAAGATAATGTATTTTATGCTAAAAAAAACATTGGTAGCTATCCTTTAAAAAAGG ATTTTAATAAATTTATTTTTGATAATTCTAAATGTTACAATATTCATAGTTTACTTGCAGTTTCA AGGTCTATTATAAGGTTATTTAATCTTGATATTTCTTCTCATATTCATATTAATGGTTCTTGTGT ATATTCTTTTGCTAAACTTTTTACAGGTTCTTATAAGGCCTACTTTTCTTTTGTAGGACTTTGGG ATATTGCAGCGTGTTTAGCTATTGGTAATAAATTGGGCATGGTTGGCGAATTTTATTGTGGTAA TAAAATGACATTAGATATCTTAGATTCAATGTATATTTTAGAGCCTAATAATCATAAAAGATGG TCCTTGAAAGATTTTTTTATTTATTCTGATAATAAATCAACAATAGACATTATAAGAAAAGATG CAAATAAAAAAATCAATAAGTAA f860.aa (SEQ ID NO:489) MAFYKLNDNIALAEDLLKYLLSSILNECSQDMDFLENYIEKGLIKKLENVINSNFEVITYTKA IEILENSKKNFEIKPYWGIDLQTDHERYLTEETFKKPVVVIDYPKNFKAFYMKANKDNKTVKGMDIL VPKIGEIIGGSEREDDLQKLENRIKELNLNIEHLNWYLDLRRFGSAPHSGFGLGLERLVQYSTGISNIR DSIPFPRTPKNLYF t860.aa (SEQ ID NO:490) CSQDMDFLENYIEKGLIKKLENVINSNFEVITYTKAIEILENSKKNFEIKPYWGIDLQTDHERYLTEET FKKPVVVIDYPKNFKAFYMKANKDNKTVKGMDILVPKIGEIIGGSEREDDLQKLENRIKELNLNIEH LNWYLDLRRFGSAPHSGFGLGLERLVQYSTGISNIRDSIPFPRTPKNLYF f860.nt (SEQ ID NO:491) ATGGCTTTTTATAAGCTTAACGACAATATTGCCCTAGCAGAAGATCTCTTGAAATATCT TTTAAGTTCAATTTTAAACGAATGCTCACAAGATATGGATTTTTTAGAAAATTACATTGAAAAA GGTTTAATTAAAAAACTAGAAAATGTAATAAATTCAAATTTTGAGGTTATTACCTATACTAAAG CAATTGAAATTCTTGAAAACTCAAAAAAAAATTTTGAAATAAAACCTTACTGGGGAATAGATTT GCAAACAGATCACGAAAGATACCTAACAGAAGAGACTTTTAAAAAACCGGTAGTGGTCATTGA TTATCCAAAAAATTTCAAAGCATTTTACATGAAAGCAAATAAAGACAATAAAACTGTTAAAGGA ATGGACATACTTGTTCCAAAAATTGGAGAGATTATAGGGGGAAGCGAAAGAGAAGATGACCTT CAAAAATTAGAAAATAGAATAAAAGAATTAAACTTAAACATTGAACATCTAAACTGGTATCTTG ATCTAAGAAGATTTGGCTCGGCTCCTCATTCTGGCTTTGGACTTGGACTTGAAAGATTGGTGCA ATACTCAACAGGAATATCTAATATAAGAGATTCAATACCATTCCCAAGGACTCCTAAAAATCTT TATTTTTAA t860.nt (SEQ ID NO:492) TGCTCACAAGATATGGATTTTTTAGAAAATTACATTGAAAAAGGTTTAATTAAAAAACTAGAAA ATGTAATAAATTCAAATTTTGAGGTTATTACCTATACTAAAGCAATTGAAATTCTTGAAAACTC AAAAAAAAATTTTGAAATAAAACCTTACTGGGGAATAGATTTGCAAACAGATCACGAAAGATA CCTAACAGAAGAGACTTTTAAAAAACCGGTAGTGGTCATTGATTATCCAAAAAATTTCAAAGCA TTTTACATGAAAGCAAATAAAGACAATAAAACTGTTAAAGGAATGGACATACTTGTTCCAAAA ATTGGAGAGATTATAGGGGGAAGCGAAAGAGAAGATGACCTTCAAAAATTAGAAAATAGAATA AAAGAATTAAACTTAAACATTGAACATCTAAACTGGTATCTTGATCTAAGAAGATTTGGCTCGG CTCCTCATTCTGGCTTTGGACTTGGACTTGAAAGATTGGTGCAATACTCAACAGGAATATCTAA TATAAGAGATTCAATACCATTCCCAAGGACTCCTAAAAATCTTTATTTTTAA f446.aa (SEQ ID NO:493) MKILRLCLLFLFFACTFDYDEYSSRSDVAKKFPSIQILGIKYYDVVYNKEQTVLNSLSFSYFNDYKIY KAENGRFLYHSLDNEISGKFNNLEGSYITKDLDMRDSVEFKIEDKNNYYLLNSNRLLWKNKDKKLQ SPPNELVLIRFNDSKINGKGFSYFLKSNVFYFDSGVEGIMN t446.aa (SEQ ID NO:494) CTFDYDEYSSRSDVAKKFPSIQILGIKYYDVVYNKEQTVLNSLSFSYFNDYKIYKAENGRFLYHSLD NEISGKFNNLEGSYITKDLDMRDSVEFKIEDKNNYYLLNSNRLLWKNKDKKLQSPPNELVLIRFNDS KINGKGFSYFLKSNVFYFDSGVEGIMN f446.nt (SEQ ID NO:495) ATGAAAATACTTAGACTTTGTTTGTTGTTTTTGTTTTTTGCTTGTACTTTTGATTATGAT GAGTATTCTAGTAGATCTGATGTGGCCAAAAAGTTTCCTTCAATACAAATATTAGGAATCAAGT ATTATGATGTTGTATACAATAAAGAGCAAACCGTTTTAAATTCTTTAAGCTTTAGTTATTTCAAT GACTATAAAATTTATAAGGCAGAGAATGGAAGGTTTTTATATCATTCCCTAGATAATGAAATTT CAGGGAAGTTTAATAATTTGGAAGGTTCTTATATTACAAAGGATTTGGATATGAGAGATTCTGT AGAATTTAAAATAGAAGATAAAAATAATTATTATTTGCTTAATTCAAATAGGCTTTTATGGAAG AATAAAGACAAGAAGTTGCAATCCCCCCCAAATGAGCTAGTATTAATTAGATTTAATGATAGCA AAATAAACGGAAAAGGATTTTCTTATTTTTTAAAGAGCAATGTTTTTTATTTTGATTCTGGAGTT GAAGGAATCATGAATTGA t446.nt (SEQ ID NO:496) TGTACTTTTGATTATGATGAGTATTCTAGTAGATCTGATGTGGCCAAAAAGTTTCCTTCAATACA AATATTAGGAATCAAGTATTATGATGTTGTATACAATAAAGAGCAAACCGTTTTAAATTCTTTA AGCTTTAGTTATTTCAATGACTATAAAATTTATAAGGCAGAGAATGGAAGGTTTTTATATCATT CCCTAGATAATGAAATTTCAGGGAAGTTTAATAATTTGGAAGGTTCTTATATTACAAAGGATTT GGATATGAGAGATTCTGTAGAATTTAAAATAGAAGATAAAAATAATTATTATTTGCTTAATTCA AATAGGCTTTTATGGAAGAATAAAGACAAGAAGTTGCAATCCCCCCCAAATGAGCTAGTATTAA TTAGATTTAATGATAGCAAAATAAACGGAAAAGGATTTTCTTATTTTTTAAAGAGCAATGTTTT TTATTTTGATTCTGGAGTTGAAGGAATCATGAATTGA f457.aa (SEQ ID NO:497) MKQKLSWILLFCFLSCRSESRLAENVLIEFFDSIKNFQSSPEIFFNYLNIPSDDDLKAKIRGLKSQAKDD FIFYPLFFNNLRYEIIGRKNISKGFEFEVVIKNINFQNGIEKFLAKLNKIEGRSLNIKNLEKKERKKIFDN LINEVIGELDDFDYTEVVHFFRVVKSSSESYKIELLGDVLNIQSRNKLINDLFLVLSPGI t457.aa (SEQ ID NO:498) CFLSCRSESRLAENVLIEFFDSIKNFQSSPEIFFNYLNIPSDDDLKAKIRGLKSQAKDDFIFYPLFFNNLR YEIIGRKNISKGFEFEVVIKNINFQNGIEKFLAKLNKIEGRSLNIKNLEKKERKKIFDNLINEVIGELDDF DYTEVVHFFRVVKSSSESYKIELLGDVLNIQSRNKLINDLFLVLSPGI f457.nt (SEQ ID NO:499) ATGAAGCAAAAATTAAGTTGGATTTTATTATTTTGTTTTTTGTCTTGTAGATCTGAATCT AGATTGGCTGAAAATGTTTTAATAGAGTTTTTTGATTCTATTAAAAATTTTCAAAGCAGTCCTG AAATATTTTTTAATTATTTAAATATTCCAAGTGATGATGATCTGAAGGCAAAAATTCGTGGGTT GAAATCTCAGGCAAAGGATGATTTCATTTTTTATCCTTTGTTTTTTAATAATCTAAGATATGAGA TAATAGGTAGAAAAAATATTTCTAAGGGCTTTGAATTTGAAGTTGTTATTAAAAATATTAACTT TCAAAACGGTATAGAAAAATTTTTGGCTAAATTAAATAAAATTGAAGGGAGATCTTTAAATATT AAAAATTTAGAAAAAAAAGAGCGTAAAAAAATATTTGACAATTTAATAAATGAAGTTATTGGA GAGTTGGATGATTTTGATTACACTGAAGTTGTTCATTTTTTTAGAGTAGTTAAGAGTTCTTCTGA AAGTTATAAAATAGAGCTTTTAGGAGATGTTTTAAATATACAGTCTAGAAATAAGCTTATTAAT GATCTTTTTTTGGTTTTATCGCCTGGAATTTAA t457.nt (SEQ ID NO:500) TGTTTTTTGTCTTGTAGATCTGAATCTAGATTGGCTGAAAATGTTTTAATAGAGTTTTTTGATTC TATTAAAAATTTTCAAAGCAGTCCTGAAATATTTTTTAATTATTTAAATATTCCAAGTGATGATG ATCTGAAGGCAAAAATTCGTGGGTTGAAATCTCAGGCAAAGGATGATTTCATTTTTTATCCTTT GTTTTTTAATAATCTAAGATATGAGATAATAGGTAGAAAAAATATTTCTAAGGGCTTTGAATTT GAAGTTGTTATTAAAAATATTAACTTTCAAAACGGTATAGAAAAATTTTTGGCTAAATTAAATA AAATTGAAGGGAGATCTTTAAATATTAAAAATTTAGAAAAAAAAGAGCGTAAAAAAATATTTG ACAATTTAATAAATGAAGTTATTGGAGAGTTGGATGATTTTGATTACACTGAAGTTGTTCATTT TTTTAGAGTAGTTAAGAGTTCTTCTGAAAGTTATAAAATAGAGCTTTTAGGAGATGTTTTAAAT ATACAGTCTAGAAATAAGCTTATTAATGATCTTTTTTTGGTTTTATCGCCTGGAATTTAA f542.aa (SEQ ID NO:501) MRIVIFIFGILLTSCFSRNGIESSSKKIKISMLVDGVLDDKSFNSSANEALLRLKKDFPENIEEVFSCAIS GVYSSYVSDLDNLKRNGSDLIWLVGYMLTDASLLVSSENPKISYGIIDPIYGDDVQIPENLIAVVFRV EPRCFFGWLYCSQKKLFWQNRFYRGNEG t542.aa (SEQ ID NO:502) CFSRNGIESSSKKIKISMLVDGVLDDKSFNSSANEALLRLKKDFPENIEEVFSCAISGVYSSYVSDLDN LKRNGSDLIWLVGYMLTDASLLVSSENPKISYGIIDPIYGDDVQIPENLIAVVFRVEPRCFFGWLYCS QKKLFWQNRFYRGNEG f542.nt (SEQ ID NO:503) ATGAGAATTGTAATTTTTATATTCGGTATTTTGTTGACTTCTTGCTTTAGTAGAAATGGAATAGA ATCTAGTTCAAAAAAAATTAAGATATCCATGTTGGTAGATGGTGTTCTTGACGACAAATCTTTT AATTCTAGTGCTAATGAGGCTTTATTACGCTTGAAAAAAGATTTTCCAGAAAATATTGAAGAAG TTTTTTCTTGTGCTATTTCTGGAGTTTATTCTAGTTATGTTTCAGATCTTGATAATTTAAAAAGG AATGGCTCAGACTTGATTTGGCTTGTAGGGTACATGCTTACGGACGCATCTTTATTGGTTTCATC GGAGAATCCAAAAATTAGCTATGGAATAATAGATCCCATTTATGGTGATGATGTTCAGATTCCT GAAAACTTGATTGCTGTTGTTTTCAGAGTAGAGCCAAGGTGCTTTTTTGGCTGGCTATATTGCA GCCAAAAAAAGCTTTTCTGGCAAAATAGGTTTTATAGGGGGAATGAAGGGTAA t542.nt (SEQ ID NO:504) TGCTTTAGTAGAAATGGAATAGAATCTAGTTCAAAAAAAATTAAGATATCCATGTTGGTAGATG GTGTTCTTGACGACAAATCTTTTAATTCTAGTGCTAATGAGGCTTTATTACGCTTGAAAAAAGA TTTTCCAGAAAATATTGAAGAAGTTTTTTCTTGTGCTATTTCTGGAGTTTATTCTAGTTATGTTT CAGATCTTGATAATTTAAAAAGGAATGGCTCAGACTTGATTTGGCTTGTAGGGTACATGCTTAC GGACGCATCTTTATTGGTTTCATCGGAGAATCCAAAAATTAGCTATGGAATAATAGATCCCATT TATGGTGATGATGTTCAGATTCCTGAAAACTTGATTGCTGTTGTTTTCAGAGTAGAGCCAAGGT GCTTTTTTGGCTGGCTATATTGCAGCCAAAAAAAGCTTTTCTGGCAAAATAGGTTTTATAGGGG GAATGAAGGGTAA f93.aa (SEQ ID NO:505) MKRILAMHDISSMGRTSLTICIPVISSFNMQVCPFVTAVLSASTAYKKFEIVDLTDHLEKFINIWKEQN EHFDILYTGFLGSEKQQITIEKIIKLIKFEKIVIDPVFADDGEIYPIFDNKIISGFRKIIKYANIITPNITELE MLSKSSKLNNKDDIIKAILNLDTKATVVVTSVKRGNLLGNICYNPKNKEYSEFFLEGLEQNFSGTGD LFTSLLIGYLEKFETEQALEKTTKAIHLIIKESIKENVSKKEGVRIENFLKNTF t93.aa (SEQ ID NO:506) CIPVISSFNMQVCPFVTAVLSASTAYKKFEIVDLTDHLEKFINIWKEQNEHFDILYTGFLGSEKQQITI EKIIKLIKFEKIVIDPVFADDGEIYPIFDNKIISGFRKIIKYANIITPNITELEMLSKSSKLNNKDDIIKAIL NLDTKATVVVTSVKRGNLLGNICYNPKNKEYSEFFLEGLEQNFSGTGDLFTSLLIGYLEKFETEQAL EKTTKAIHLIIKESIKENVSKKEGVRIENFLKNTF f93.nt (SEQ ID NO:507) ATGAAAAGAATTTTAGCAATGCATGATATTTCAAGCATGGGAAGAACATCTCTTACAATATGCA TACCAGTAATATCTTCGTTTAATATGCAAGTTTGTCCTTTTGTGACAGCTGTCCTTTCTGCTTCC ACAGCTTATAAAAAATTTGAAATAGTGGATTTAACCGATCATTTAGAAAAATTTATCAATATAT GGAAAGAACAAAATGAGCACTTTGACATACTCTATACCGGATTTCTGGGAAGCGAAAAACAAC AAATAACAATAGAGAAAATAATTAAATTAATAAAATTTGAAAAAATTGTAATTGATCCTGTGTT TGCTGACGATGGAGAAATTTACCCTATATTTGATAATAAAATAATTAGTGGATTTAGAAAAATC ATAAAGTACGCAAACATAATAACACCCAATATCACAGAACTTGAAATGCTAAGCAAAAGCTCA AAACTTAACAACAAAGATGATATCATAAAAGCAATATTAAATCTTGATACAAAAGCGACGGTA GTTGTTACAAGCGTTAAAAGGGGAAATCTCTTGGGAAACATTTGCTACAATCCTAAAAACAAAG AATACTCGGAGTTTTTTTTAGAAGGATTAGAACAAAATTTCAGTGGAACAGGAGATTTATTTAC CAGCTTACTTATAGGATATTTGGAAAAATTTGAAACAGAGCAAGCCTTAGAAAAAACAACAAA GGCTATTCACCTAATAATAAAAGAGTCAATTAAAGAAAATGTTTCAAAAAAAGAAGGGGTCCG AATTGAAAATTTCTTAAAAAATACATTTTGA t93.nt (SEQ ID NO:508) TGCATACCAGTAATATCTTCGTTTAATATGCAAGTTTGTCCTTTTGTGACAGCTGTCCTTTCTGC TTCCACAGCTTATAAAAAATTTGAAATAGTGGATTTAACCGATCATTTAGAAAAATTTATCAAT ATATGGAAAGAACAAAATGAGCACTTTGACATACTCTATACCGGATTTCTGGGAAGCGAAAAA CAACAAATAACAATAGAGAAAATAATTAAATTAATAAAATTTGAAAAAATTGTAATTGATCCTG TGTTTGCTGACGATGGAGAAATTTACCCTATATTTGATAATAAAATAATTAGTGGATTTAGAAA AATCATAAAGTACGCAAACATAATAACACCCAATATCACAGAACTTGAAATGCTAAGCAAAAG CTCAAAACTTAACAACAAAGATGATATCATAAAAGCAATATTAAATCTTGATACAAAAGCGAC GGTAGTTGTTACAAGCGTTAAAAGGGGAAATCTCTTGGGAAACATTTGCTACAATCCTAAAAAC AAAGAATACTCGGAGTTTTTTTTAGAAGGATTAGAACAAAATTTCAGTGGAACAGGAGATTTAT TTACCAGCTTACTTATAGGATATTTGGAAAAATTTGAAACAGAGCAAGCCTTAGAAAAAACAAC AAAGGCTATTCACCTAATAATAAAAGAGTCAATTAAAGAAAATGTTTCAAAAAAAGAAGGGGT CCGAATTGAAAATTTCTTAAAAAATACATTTTGA f105.aa (SEQ ID NO:509) MGLYLKLLRQSINLKSLFPLSVLFFSCNVVDTDFSVLEFKVANFNLNDDFSQGLLDSAYNILNRSFDL IIIKNLKNKNVLDLINNRVLFRAFKNAYFIDQGSGLSVSILSKRKINIKVLSVMQDSCDLKLGLLVDFK FENNHYGIVIYNLSKDFIKSIANLQISEQILYLKAQMDKLMFILDESEFVIFDLLIKNGFFSLINDSNYTS MLANKIDFRVFSNFFARVSLYSFMFVIADYLHSNYVVENFPQKIVIN t105.aa (SEQ ID NO:510) CNVVDTDFSVLEFKVANFNLNDDFSQGLLDSAYNILNRSFDLIIIKNLKNKNVLDLINNRVLFRAFKN AYFIDQGSGLSVSILSKRKINIKVLSVMQDSCDLKLGLLVDFKFENNHYGIVIYNLSKDFIKSIANLQIS EQILYLKAQMDKLMFILDESEFVIFDLLIKNGFFSLINDSNYTSMLANKIDFRVFSNFFARVSLYSFMF VIADYLHSNYVVENFPQKIVIN f105.nt (SEQ ID NO:511) ATGGGCTTGTATTTGAAGTTGTTGAGACAAAGTATCAACTTGAAGAGTTTATTTCCGCTTAGTG TTTTATTTTTTTCCTGTAATGTTGTAGATACAGATTTTAGTGTTTTGGAGTTTAAGGTTGCAAAT TTTAATTTAAATGATGATTTTTCTCAAGGGTTACTTGATTCTGCTTATAATATTCTAAATCGAAG TTTTGATTTAATAATTATTAAGAATCTTAAGAATAAAAATGTTCTTGATTTAATTAATAATAGAG TTTTATTTAGAGCTTTTAAGAATGCTTATTTTATTGATCAAGGTAGTGGCCTTTCTGTTAGCATT CTTTCTAAGCGCAAAATAAATATTAAAGTTTTAAGTGTAATGCAAGATTCTTGCGATTTAAAAT TAGGATTGCTTGTGGATTTTAAATTTGAGAATAATCACTATGGTATTGTTATTTATAATTTAAGC AAGGATTTTATTAAAAGTATTGCCAATTTGCAAATTAGTGAACAAATTTTATATTTAAAAGCCC AAATGGATAAATTGATGTTTATTTTAGATGAATCTGAATTTGTTATTTTTGATTTATTAATCAAA AATGGATTTTTTAGCTTAATAAATGATTCAAACTACACTTCAATGTTAGCAAATAAAATTGATTT TAGAGTTTTTTCTAATTTTTTTGCTAGGGTTTCTTTATATTCATTTATGTTTGTAATTGCAGATTA TTTGCATAGCAATTATGTTGTTGAGAATTTTCCTCAAAAAATAGTTATCAATTGA t105.nt (SEQ ID NO:512) TGTAATGTTGTAGATACAGATTTTAGTGTTTTGGAGTTTAAGGTTGCAAATTTTAATTTAAATGA TGATTTTTCTCAAGGGTTACTTGATTCTGCTTATAATATTCTAAATCGAAGTTTTGATTTAATAA TTATTAAGAATCTTAAGAATAAAAATGTTCTTGATTTAATTAATAATAGAGTTTTATTTAGAGCT TTTAAGAATGCTTATTTTATTGATCAAGGTAGTGGCCTTTCTGTTAGCATTCTTTCTAAGCGCAA AATAAATATTAAAGTTTTAAGTGTAATGCAAGATTCTTGCGATTTAAAATTAGGATTGCTTGTG GATTTTAAATTTGAGAATAATCACTATGGTATTGTTATTTATAATTTAAGCAAGGATTTTATTAA AAGTATTGCCAATTTGCAAATTAGTGAACAAATTTTATATTTAAAAGCCCAAATGGATAAATTG ATGTTTATTTTAGATGAATCTGAATTTGTTATTTTTGATTTATTAATCAAAAATGGATTTTTTAG CTTAATAAATGATTCAAACTACACTTCAATGTTAGCAAATAAAATTGATTTTAGAGTTTTTTCTA ATTTTTTTGCTAGGGTTTCTTTATATTCATTTATGTTTGTAATTGCAGATTATTTGCATAGCAATT ATGTTGTTGAGAATTTTCCTCAAAAAATAGTTATCAATTGA f150.aa (SEQ ID NO:513) MKTFVIIGLSNLGIHLLEDLSRLDCQIIIIDTSKELIEEYDVISTESFVVEQFTKNALKRIIPVDTDAVVID FDDDLGKSALVTHYCNLLGLKEICVKTENRDDAEILKTLGATKIIFPSKDAARRLTPLLVSPNLSTYN IIGYDIIVAETVIPKEYVGKTLFEADLRRECGITVIAVRNLSNSRYEFVDGDYFFLKDDKIVICGKPDSI ENFTNNKDLIKDLISGSKEDENLNKDAEKKSRFLGIFNFMKIFQKDRKDN t150.aa (SEQ ID NO:514) CQIIIIDTSKELIEEYDVISTESFVVEQFTKNALKRIIPVDTDAVVIDFDDDLGKSALVTHYCNLLGLKE ICVKTENRDDAEILKTLGATKIIFPSKDAARRLTPLLVSPNLSTYNIIGYDIIVAETVIPKEYVGKTLFE ADLRRECGITVIAVRNLSNSRYEFVDGDYFFLKDDKIVICGKPDSIENFTNNKDLIKDLISGSKEDENL NKDAEKKSRFLGIFNFMKIFQKDRKDN f150.nt (SEQ ID NO:515) ATGAAAACATTTGTTATTATTGGACTTAGTAATTTAGGCATTCACTTACTTGAAGATTT AAGCAGGCTTGATTGTCAAATTATTATTATAGATACATCTAAAGAGCTTATTGAAGAATATGAT GTGATATCTACAGAAAGCTTTGTTGTTGAGCAATTCACTAAAAATGCTTTGAAAAGAATAATTC CAGTAGATACAGACGCTGTTGTTATTGATTTTGATGATGATCTTGGCAAAAGTGCTCTTGTTACT CACTATTGTAATCTTTTAGGTTTGAAAGAAATATGCGTTAAGACAGAAAATAGAGATGATGCTG AAATCTTAAAAACTCTTGGGGCAACAAAAATTATATTTCCAAGTAAAGATGCTGCAAGAAGATT AACTCCATTATTAGTATCTCCAAATCTTTCAACTTATAATATTATTGGGTATGATATTATTGTTG CTGAAACTGTTATTCCCAAAGAATATGTTGGTAAAACTCTTTTTGAAGCCGATCTTAGAAGAGA ATGTGGGATTACAGTTATTGCTGTTAGAAATTTAAGTAATTCTAGGTATGAATTTGTTGATGGC GATTATTTTTTTTTAAAAGATGATAAAATTGTAATTTGTGGTAAACCAGATAGCATTGAAAATT TTACAAATAATAAAGATTTAATTAAAGATTTAATTTCAGGCTCTAAAGAGGATGAAAATTTAAA TAAAGATGCTGAGAAAAAATCTAGATTTTTAGGGATTTTCAATTTTATGAAAATTTTTCAAAAA GATCGTAAGGATAATTAG t150.nt (SEQ ID NO:516) TGTCAAATTATTATTATAGATACATCTAAAGAGCTTATTGAAGAATATGATGTGATATCTACAG AAAGCTTTGTTGTTGAGCAATTCACTAAAAATGCTTTGAAAAGAATAATTCCAGTAGATACAGA CGCTGTTGTTATTGATTTTGATGATGATCTTGGCAAAAGTGCTCTTGTTACTCACTATTGTAATC TTTTAGGTTTGAAAGAAATATGCGTTAAGACAGAAAATAGAGATGATGCTGAAATCTTAAAAA CTCTTGGGGCAACAAAAATTATATTTCCAAGTAAAGATGCTGCAAGAAGATTAACTCCATTATT AGTATCTCCAAATCTTTCAACTTATAATATTATTGGGTATGATATTATTGTTGCTGAAACTGTTA TTCCCAAAGAATATGTTGGTAAAACTCTTTTTGAAGCCGATCTTAGAAGAGAATGTGGGATTAC AGTTATTGCTGTTAGAAATTTAAGTAATTCTAGGTATGAATTTGTTGATGGCGATTATTTTTTTT TAAAAGATGATAAAATTGTAATTTGTGGTAAACCAGATAGCATTGAAAATTTTACAAATAATAA AGATTTAATTAAAGATTTAATTTCAGGCTCTAAAGAGGATGAAAATTTAAATAAAGATGCTGAG AAAAAATCTAGATTTTTAGGGATTTTCAATTTTATGAAAATTTTTCAAAAAGATCGTAAGGATA ATTAG f219.aa (SEQ ID NO:517) MLIARIMNINTLFYGMIIIIFALISCNHKNIQYDKRIKKFLDKNKIEYKIDSENDFIAFKDINNNEKEEVI IRSRLNSYKNSKIREIFGIVKVFDINTPKIKEISDSLMSDSYNNRVFGSWEIIHNAERGINSLVYIVKAE EFANDTFLLDAIDEIASTISIFKKIITTNNENIDNNEENNNTNESNEQPTLKQEKTNSTKESNNELKED QIEEELQEIKAQ t219.aa (SEQ ID NO:518) CNHKNIQYDKRIKKFLDKNKIEYKIDSENDFIAFKDINNNEKEEVIIRSRLNSYKNSKIREIFGIVKVFD INTPKIKEISDSLMSDSYNNRVFGSWEIIHNAERGINSLVYIVKAEEFANDTFLLDAIDEIASTISIFKKII TTNNENIDNNEENNNTNESNEQPTLKQEKTNSTKESNNELKEDQIEEELQEIKAQ f219.nt (SEQ ID NO:519) ATGCTAATTGCAAGAATAATGAATATTAATACATTATTCTACGGCATGATCATTATCATTTTTGC ACTCATTTCTTGCAATCATAAGAATATACAGTACGACAAGAGAATTAAAAAATTTTTAGATAAA AACAAAATTGAATATAAAATAGACTCAGAAAATGACTTTATAGCATTTAAAGATATAAACAATA ACGAAAAAGAAGAAGTAATCATCAGATCAAGACTAAACTCATATAAAAATTCAAAGATAAGAG AAATATTTGGAATTGTTAAAGTATTTGATATAAACACACCAAAAATAAAAGAAATATCTGACTC GCTTATGAGCGATAGTTATAATAACAGAGTATTTGGATCGTGGGAGATTATTCATAATGCAGAA AGAGGAATCAACTCTTTGGTATATATTGTAAAAGCAGAAGAATTTGCAAATGATACATTTTTGC TTGATGCAATTGATGAGATTGCCTCAACAATAAGTATTTTCAAAAAAATAATAACAACCAACAA CGAAAACATTGATAATAATGAAGAAAATAACAATACAAATGAATCAAATGAACAGCCCACCTT AAAGCAAGAAAAAACAAATTCAACAAAAGAATCTAATAACGAACTTAAAGAAGATCAAATAGA AGAAGAACTTCAAGAAATCAAAGCCCAATAA t219.nt (SEQ ID NO:520) TGCAATCATAAGAATATACAGTACGACAAGAGAATTAAAAAATTTTTAGATAAAAACAAAATT GAATATAAAATAGACTCAGAAAATGACTTTATAGCATTTAAAGATATAAACAATAACGAAAAA GAAGAAGTAATCATCAGATCAAGACTAAACTCATATAAAAATTCAAAGATAAGAGAAATATTT GGAATTGTTAAAGTATTTGATATAAACACACCAAAAATAAAAGAAATATCTGACTCGCTTATGA GCGATAGTTATAATAACAGAGTATTTGGATCGTGGGAGATTATTCATAATGCAGAAAGAGGAA TCAACTCTTTGGTATATATTGTAAAAGCAGAAGAATTTGCAAATGATACATTTTTGCTTGATGC AATTGATGAGATTGCCTCAACAATAAGTATTTTCAAAAAAATAATAACAACCAACAACGAAAA CATTGATAATAATGAAGAAAATAACAATACAAATGAATCAAATGAACAGCCCACCTTAAAGCA AGAAAAAACAAATTCAACAAAAGAATCTAATAACGAACTTAAAGAAGATCAAATAGAAGAAGA ACTTCAAGAAATCAAAGCCCAATAA f229.aa (SEQ ID NO:521) MRVDLLPLVELSLYINLSFCCKDFSIFNRILEELKCHLILLGHPIIKTLYIKHVDFCLSRQDNLKFIFTSL SKYINLELLEEFTLEIIPGYVDFEKFKLLDEFCITRINLNVQSFSLEFRKIVGIPEISYKKLNILINNIRKFP FDLNIDMTVNMPLQKKSHLKRDLQRIAFIYA t229.aa (SEQ ID NO:522) CKDFSIFNRILEELKCHLILLGHPIIKTLYLKHVDFCLSRQDNLKFIFTSLSKYINLELLEEFTLEIIPGYV DFEKFKLLDEFCITRINLNVQSFSLEFRKIVGIPEISYKKLNILINNIRKFPFDLNIDMTVNMPLQKKSH LKRDLQRIAFIYA f229.nt (SEQ ID NO:523) ATGAGAGTAGATCTTTTACCTCTTGTCGAGTTAAGTCTTTATATTAATTTGTCATTTTGTTGTAA AGATTTTAGCATTTTTAATAGAATTTTAGAGGAATTAAAATGTCATTTAATCTTGCTGGGTCATC CAATTATAAAAACACTTTACATTAAGCACGTAGATTTTTGTTTATCTAGGCAAGATAATTTAAA ATTTATTTTCACTTCTTTGTCCAAGTATATTAATTTGGAGTTATTAGAAGAATTTACTTTAGAAA TTATTCCGGGTTATGTTGATTTTGAAAAATTCAAACTTTTGGATGAATTTTGTATTACTAGAATT AATCTTAATGTTCAAAGTTTTTCTTTAGAGTTTAGAAAGATTGTGGGGATACCCGAAATTTCTTA TAAAAAATTGAATATTTTGATTAACAATATTAGAAAGTTTCCTTTTGATTTGAATATTGACATGA CTGTCAATATGCCTTTGCAAAAAAAATCTCATCTCAAGCGAGATTTGCAAAGAATTGCTTTCAT ATATGCCTGA t229.nt (SEQ ID NO:524) TGTAAAGATTTTAGCATTTTTAATAGAATTTTAGAGGAATTAAAATGTCATTTAATCTTGCTGG GTCATCCAATTATAAAAACACTTTACATTAAGCACGTAGATTTTTGTTTATCTAGGCAAGATAA TTTAAAATTTATTTTCACTTCTTTGTCCAAGTATATTAATTTGGAGTTATTAGAAGAATTTACTT TAGAAATTATTCCGGGTTATGTTGATTTTGAAAAATTCAAACTTTTGGATGAATTTTGTATTACT AGAATTAATCTTAATGTTCAAAGTTTTTCTTTAGAGTTTAGAAAGATTGTGGGGATACCCGAAA TTTCTTATAAAAAATTGAATATTTTGATTAACAATATTAGAAAGTTTCCTTTTGATTTGAATATT GACATGACTGTCAATATGCCTTTGCAAAAAAAATCTCATCTCAAGCGAGATTTGCAAAGAATTG CTTTCATATATGCCTGA f22.aa (SEQ ID NO:525) MLKTLTKIITISCLIVGCASLPYTPPKQNLNYLMELLPGANLYAHVNLIKNRSIYNSLSPKYKSVLGLI SNLYFSYKKENNDFALLIMGNFPKDIFWGIHKNRNTESIGNIFTNPKWKLKNSNIYIIPNKARTSIAIT QKDITAKDNNMLTTKYIGEIEKNEMFFWIQDPTLLLPNQIVSSKNLIPFSSGTLSINSLNQEEYIFKSLI KTNNPPILKILSKKLIPTVLTNMTNLTISSHIKTTIKDQNTVEIEFNIQKSSVESLIEKLASNIQT t22.aa (SEQ ID NO:526) CASLPYTPPKQNLNYLMELLPGANLYAHVNLIKNRSIYNSLSPKYKSVLGLISNLYFSYKKENNDFA LLIMGNFPKDIFWGIHKNRNTESIGNIFTNPKWKLKNSNIYIIPNKARTSIAITQKDITAKDNNMLTTK YIGEIEKNEMFFWIQDPTLLLPNQIVSSKNLIPFSSGTLSINSLNQEEYIFKSLIKTNNPPILKILSKKLIPT VLTNMTNLTISSHIKTTIKDQNTVEIEFNIQKSSVESLIEKLASNIQT f22.nt (SEQ D NO:527) ATGTTAAAAACATTAACAAAAATAATTACCATTTCATGCCTCATAGTGGGATGCGCAAGCCTGC CTTACACTCCTCCAAAACAAAATCTAAATTACTTAATGGAACTTTTACCTGGCGCAAATTTATAC GCCCATGTAAATTTAATTAAAAACAGGTCTATTTATAACTCTTTAAGCCCTAAATATAAATCAG TTCTTGGGCTTATAAGCAATTTATACTTTAGCTATAAAAAAGAAAATAACGATTTTGCTCTACTA ATAATGGGTAATTTCCCAAAAGATATTTTCTGGGGAATTCATAAAAATAGAAATACAGAATCAA TAGGCAATATATTTACAAATCCAAAATGGAAACTTAAAAATTCAAATATATACATTATTCCAAA CAAAGCTAGAACTAGCATTGCAATAACCCAAAAAGATATAACCGCAAAAGACAATAATATGCT AACAACAAAATATATTGGGGAAATAGAAAAAAATGAAATGTTTTTTTGGATTCAAGATCCAAC ATTATTGCTCCCAAACCAAATAGTAAGCAGCAAAAATTTAATTCCCTTTAGCAGTGGAACTTTG TCTATAAACAGCTTAAATCAAGAAGAATATATTTTTAAATCCTTAATCAAAACAAATAATCCAC CAATACTAAAAATATTGTCAAAAAAGTTAATTCCAACCGTCTTGACAAACATGACAAACCTCAC AATATCAAGCCACATAAAGACCACAATAAAAGACCAAAATACGGTTGAAATAGAATTTAATAT TCAAAAATCTAGTGTTGAAAGCCTTATAGAAAAACTAGCTTCAAATATTCAAACCTAA t22.nt (SEQ ID NO:528) TGCGCAAGCCTGCCTTACACTCCTCCAAAACAAAATCTAAATTACTTAATGGAACTTTTACCTG GCGCAAATTTATACGCCCATGTAAATTTAATTAAAAACAGGTCTATTTATAACTCTTTAAGCCCT AAATATAAATCAGTTCTTGGGCTTATAAGCAATTTATACTTTTAGCTATAAAAAAGAAAATAACG ATTTGCTCTACTAATAATGGGTAATTTCCCAAAAGATATTTTCTGGGGAATTCATAAAAATAG AAATACAGAATCAATAGGCAATATATTTACAAATCCAAAATGGAAACTTAAAAATTCAAATATA TACATTATTCCAAACAAAGCTAGAACTAGCATTGCAATAACCCAAAAAGATATAACCGCAAAA GACAATAATATGCTAACAACAAAATATATTGGGGAAATAGAAAAAAATGAAATGTTTTTTTGG ATTCAAGATCCAACATTATTGCTCCCAAACCAAATAGTAAGCAGCAAAAATTTAATTCCCTTTA GCAGTGGAACTTTGTCTATAAACAGCTTAAATCAAGAAGAATATATTTTTAAATCCTTAATCAA AACAAATAATCCACCAATACTAAAAATATTGTCAAAAAAGTTAATTCCAACCGTCTTGACAAAC ATGACAAACCTCACAATATCAAGCCACATAAAGACCACAATAAAAGACCAAAATACGGTTGAA ATAGAATTTAATATTCAAAAATCTAGTGTTGAAAGCCTTATAGAAAAACTAGCTTCAAATATTC AAACCTAA f32.aa (SEQ ID NO:529) MNTKTLYLISLILLACNKNNKIPLIQKLDLPKSSILGFSNKMGIIIKDYAFLSKSTKKNSELDYDYAILL RKDEVKKIEKTLEKTERYGIEGNWILVNYKGTKRYIFSKDINIVNNLIIDHSK t32.aa (SEQ ID NO:530) CNKNNKIPLIQKLDLPKSSILGFSNKMGIIIKDYAFLSKSTKKNSELDYDYAILLRKDEVVKIEKTLEK TERYGIEGNWILVNYKGTKRYIFSKDINIVNNLIIDHSK f32.nt (SEQ ID NO:531) ATGAATACAAAAACATTATATTTAATATCCTTAATTCTTTTAGCTTGCAATAAAAATAACAAAA TTCCTCTCATTCAAAAATTAGATTTGCCCAAAAGCAGCATTCTTGGCTTTAGCAATAAAATGGG CATAATAATAAAAGATTATGCTTTTCTTAGTAAAAGCACTAAGAAAAATAGCGAATTGGATTAT GATTACGCAATTCTACTCAGAAAAGACGAAGTCGTAAAAATTGAAAAAACACTAGAAAAAACA GAGCGCTATGGAATTGAAGGAAATTGGATCCTAGTCAATTACAAGGGAACTAAAAGATACATC TTTAGCAAAGACATCAATATAGTCAACAATTTAATAATTGATCATTCTAAATAG t32.nt (SEQ ID NO:532) TGCAATAAAAATAACAAAATTCCTCTCATTCAAAAATTAGATTTGCCCAAAAGCAGCATTCTTG GCTTTAGCAATAAAATGGGCATAATAATAAAAGATTATGCTTTTCTTAGTAAAAGCACTAAGAA AAATAGCGAATTGGATTATGATTACGCAATTCTACTCAGAAAAGACGAAGTCGTAAAAATTGA AAAAACACTAGAAAAAACAGAGCGCTATGGAATTGAAGGAAATTGGATCCTAGTCAATTACAA GGGAACTAAAAGATACATCTTTAGCAAAGACATCAATATAGTCAACAATTTAATAATTGATCAT TCTAAATAG f186.aa (SEQ ID NO:533) MKKLIIIFTLFLSQACNLSTMHKIDTKEDMKILYSEIAELRKKLNLNHLEIDDTLEKVAKEYAIKLGEN RTITHTLFGTTPMQRIHKYDQSFNLTREILASGIELNRVVNAWLNSPSHKEALINTDTDKIGGYRLKT TDNIDIFVVLFGKRKYKN t186.aa (SEQ ID NO:534) CNLSTMHKIDTKEDMKILYSEIAELRKKLNLNHLEIDDTLEKVAKEYAIKLGENRTITHTLFGTT PMQRIHKYDQSFNLTREILASGIELNRVVNAWLNSPSHKEALINTDTDKIGGYRLKTTDNIDIFVVLF GKRKYKN f186.nt (SEQ ID NO:535) ATGAAAAAATTGATTATAATTTTTACACTGTTTTTATCTCAAGCATGCAATTTAAGTACAATGCA TAAAATAGATACAAAAGAAGATATGAAAATTCTATATTCAGAAATTGCTGAATTGAGAAAAAA ATTAAATCTAAACCATCTAGAAATAGATGATACCCTTGAAAAAGTTGCAAAAGAATATGCCATT AAACTGGGAGAAAATAGAACAATAACTCACACCCTTTTTGGCACAACCCCAATGCAAAGAATA CATAAATACGATCAATCCTTTAATTTAACAAGAGAAATACTGGCATCAGGAATTGAACTTAACA GAGTAGTTAATGCATGGCTTAATAGTCCAAGCCACAAAGAAGCTCTTATTAATACAGATACCGA TAAAATAGGTGGCTATAGATTAAAAACGACTGACAATATAGATATATTTGTAGTTCTTTTTGGA AAAAGAAAATATAAGAATTGA t186.nt (SEQ ID NO:536) TGCAATTTAAGTACAATGCATAAAATAGATACAAAAGAAGATATGAAAATTCTATATTCAGAA ATTGCTGAATTGAGAAAAAAATTAAATCTAAACCATCTAGAAATAGATGATACCCTTGAAAAA GTTGCAAAAGAATATGCCATTAAACTGGGAGAAAATAGAACAATAACTCACACCCTTTTTGGCA CAACCCCAATGCAAAGAATACATAAATACGATCAATCCTTTAATTTAACAAGAGAAATACTGGC ATCAGGAATTGAACTTAACAGAGTAGTTAATGCATGGCTTAATAGTCCAAGCCACAAAGAAGC TCTTATTAATACAGATACCGATAAAATAGGTGGCTATAGATTAAAAACGACTGACAATATAGAT ATATTTGTAGTTCTTTTTGGAAAAAGAAAATATAAGAATTGA f216.aa (SEQ ID NO:537) MIRVLLGSLAVSFLFSICMVFLNYDNLFSKKVFYFHSSKGFVANLRYLRDEQNLKDNLDLLVKDFLL GSNEGFSFGFLLSDSRFLYSFLKNGVYYVNLSREFYDSFNNGDYNESNESFDVKVNLFAMSLIKTMR FNYPGKIKKIVILVEGCILKEQS t216.aa (SEQ ID NO:538) CMVFLNYDNLFSKKVFYFHSSKGFVANLRYLRDEQNLKDNLDLLVKDFLLGSNEGFSFGFLLSDSRF LYSFLKNGVYYVNLSREFYDSFNNGDYNESNESFDVKVNLFAMSLIKTMRFNYPGKIKKIVILVEGC ILKEQS f216.nt (SEQ ID NO:539) ATGATTAGGGTGCTTTTGGGGTCTTTGGCAGTAAGCTTTTTGTTTTCTATTTGTATGGTTTTTTT AAATTATGATAATCTTTTTTCAAAAAAGGTTTTTTATTTTCATTCTAGCAAGGGATTTGTTGCTA ATTTAAGATATTTAAGAGATGAACAAAATTTGAAAGATAATTTAGATCTTTTAGTAAAAGATTT TCTTTTAGGAAGCAATGAAGGGTTTTCTTTTGGGTTTTTATTAAGTGATTCAAGATTTTTATATT CTTTTTTAAAGAATGGAGTTTATTATGTAAATCTTTCAAGAGAATTTTATGATTCTTTTAATAAT GGTGATTATAATGAATCTAATGAATCTTTTGATGTTAAGGTCAATCTTTTTGCTATGTCTTTAAT AAAAACAATGCGCTTTAACTATCCTGGTAAGATAAAAAAGATTGTTATTCTTGTTGAAGGGTGT ATCTTAAAGGAGCAAAGTTGA t216.nt (SEQ ID NO:540) TGTATGGTTTTTTTAAATTATGATAATCTTTTTTCAAAAAAGGTTTTTTATTTTCATTCTAGCAA GGGATTTGTTGCTAATTTAAGATATTTAAGAGATGAACAAAATTTGAAAGATAATTTAGATCTT TTAGTAAAAGATTTTCTTTTAGGAAGCAATGAAGGGTTTTCTTTTGGGTTTTTATTAAGTGATTC AAGATTTTTATATTCTTTTTTAAAGAATGGAGTTTATTATGTAAATCTTTCAAGAGAATTTTATG ATTCTTTTAATAATGGTGATTATAATGAATCTAATGAATCTTTTGATGTTAAGGTCAATCTTTTT GCTATGTCTTTAATAAAAACAATGCGCTTTAACTATCCTGGTAAGATAAAAAAGATTGTTATTC TTGTTGAAGGGTGTATCTTAAAGGAGCAAAGTTGA f328.aa (SEQ ID NO:541) MAIKYARENNIPFLGICLGLQLAVIEFARNVCGILDADTEENLARDKPLKSPVIHLLPEQKGIKDKGA TMRLGGYPVILKKNTIAFKLYGQDRIIERFRHRYEVNNDYIDLFAKNGLIVSGFSSDFKMAKLIEIPEN KFFVACQFHPELITRIENPAKLFLGLIKACI t328.aa (SEQ ID NO:542) CLGLQLAVIEFARNVCGILDADTEENLARDKPLKSPVIHLLPEQKGIKDKGATMRLGGYPVILKKNTI AFKLYGQDRIIERFRHRYEVNNDYIDLFAKNGLIVSGFSSDFKMAKLIEIPENKFFVACQFHPELITRIE NPAKLF LGLIKACI f328.nt (SEQ ID NO:543) ATGGCTATTAAATATGCTCGTGAGAATAATATTCCCTTTCTTGGAATTTGTCTTGGTTTGCAGCT TGCTGTAATAGAATTTGCTCGTAATGTTTGTGGAATACTTGATGCTGATACGGAGGAAAATTTA GCAAGAGACAAGCCCTTAAAAAGTCCTGTTATCCATTTACTTCCTGAGCAAAAGGGAATTAAAG ATAAGGGCGCTACAATGAGGCTTGGTGGATATCCTGTGATTCTTAAAAAGAATACAATAGCTTT TAAACTTTATGGCCAAGATCGGATAATTGAAAGATTTAGACATAGGTATGAAGTCAATAATGAT TATATAGATTTATTTGCAAAAAATGGGCTTATAGTATCTGGATTTTCAAGTGATTTTAAAATGG CAAAATTAATAGAAATTCCTGAAAATAAATTTTTCGTAGCTTGCCAGTTTCATCCAGAACTTATT ACAAGAATAGAAAATCCAGCCAAGCTTTTTCTAGGATTAATTAAAGCTTGTATTTGA t328.nt (SEQ ID NO:544) TGTCTTGGTTTGCAGCTTGCTGTAATAGAATTTGCTCGTAATGTTTGTGGAATACTTGATGCTGA TACGGAGGAAAATTTAGCAAGAGACAAGCCCTTAAAAAGTCCTGTTATCCATTTACTTCCTGAG CAAAAGGGAATTAAAGATAAGGGCGCTACAATGAGGCTTGGTGGATATCCTGTGATTCTTAAA AAGAATACAATAGCTTTTAAACTTTATGGCCAAGATCGGATAATTGAAAGATTTAGACATAGGT ATGAAGTCAATAATGATTATATAGATTTATTTGCAAAAAATGGGCTTATAGTATCTGGATTTTC AAGTGATTTTAAAATGGCAAAATTAATAGAAATTCCTGAAAATAAATTTTTCGTAGCTTGCCAG TTTCATCCAGAACTTATTACAAGAATAGAAAATCCAGCCAAGCTTTTTCTAGGATTAATTAAAG CTTGTATTTGA f352.aa (SEQ ID NO:545) MNKTKNRSLTYFIILSCISLFGANNNTISYSSIEIPLEDLSEEFKSSGNKSDQINTSKHLNKNIVSYEDPK KGKDLKLPENIRDKKLPQKRMDENDLKSVIENYENKIKNIEKLLKTKNQKTSENENKKIESIEKKAK KYEILTNKLKNEIVEIKKLLNKKIKPKEDENYEKINIENIEEETDDDFEDNYEYNDEIEXTNEDNYPSN EGIINNLKENLNENEKYYAINEKKIDELEDRINENENTILDLQRELRNFKKKDNSDKNLEEIEENLSSI GRIINDLKRKISANEAINKENQKKIRTDKHKLKELEDKIKENEETILKLQKELNNFKKKEIYQKPLNE ETFTPSITSKNDDLEENKKLKKEYLKPIEKKESRDLEENTKSTPKTTMIKTADFQIYPDIYLNNYKFK EKGDQFAFKKENTYYIEIDPTNNLNEALKNHEIISKYKFEKYFINPILKNKEEFFRNLIEVKNIHELGIM YKNLKPEFKQIKIIK t352.aa (SEQ ID NO:546) CISLFGANNNTISYSSIEIPLEDLSEEFKSSGNKSDQINTSKHLNKNIVSYEDPKKGKDLKLPENIRDKK LPQKRMDENDLKSVIENYENKIKNIEKLLKTKNQKTSENENKKIESIEKKAKKYEILTNKLKNETVEI KKLLNKKIKPKEDENYEKINIENIEEETDDDFEDNYEYNDEIEXTNEDNYPSNEGIINNLKENLNENE KYYAINEKKIDELEDRINENENTILDLQRELRNFKKKDNSDKNLEEIEENLSSIGRIINDLKRKISANEA INKENQKKIRTDKHKLKELEDKIKENEETILKLQKELNNFKKKEIYQKPLNEETFTPSITSKNDDLEE NKKLKKEYLKPIEKKESRDLEENTKSTPKTTMIKTADFQIYPDIYLNNYKFKEKGDQFAFKKENTYY IEIDPTNNLNEALKNHEIISKYKFEKYFINPILKNKEEFFRNLIEVKNIHELGIMYKNLKPEFKQIKIIK f352.nt (SEQ ID NO:547) ATGAATAAAACAAAAAATCGAAGCCTTACGTATTTTATAATACTTTCATGTATATCATTATTTG GGGCTAATAATAATACAATAAGCTACTCTAGCATTGAAATTCCTCTAGAAGACTTAAGTGAAGA ATTTAAAAGTTCTGGGAATAAAAGCGATCAAATAAATACCTCAAAACATTTAAACAAAAACAT AGTTTCTTATGAAGACCCAAAAAAGGGTAAAGATCTAAAATTGCCAGAAAATATAAGAGACAA AAAACTACCCCAAAAAAGAATGGACGAAAATGATCTAAAATCTGTAATTGAAAATTATGAAAA TAAAATTAAAAACATAGAAAAGCTTTTAAAAACCAAAAATCAAAAAACATCGGAAAATGAAAA TAAAAAAATAGAATCAATCGAAAAAAAAGCAAAAAAATATGAAATTTTAACCAATAAATTAAA AAACGAAATAGTAGAAATAAAAAAGCTCCTTAACAAAAAAATCAAGCCTAAAGAAGATGAAAA TTACGAAAAAATAAATATTGAAAACATTGAAGAAGAAACTGATGATGATTTTGAAGACAATTA TGAATATAATGATGAAATTGAAGAACAAATGAGGACAATTACCCTTCTAATGAAGGAATAATA AACAATCTAAAAGAAAATCTTAATGAAAACGAAAAATATTATGCTATTAATGAAAAAAAAATC GATGAACTTGAAGACAGAATCAACGAGAATGAAAACACTATTTTAGACTTGCAAAGAGAATTA AGGAATTTTAAAAAAAAAGATAACTCAGATAAAAACTTAGAAGAAATTGAGGAAAATTTATCT TCAATAGGAAGAATAATTAATGATCTAAAAAGAAAAATCAGCGCAAATGAAGCAATAAACAAA GAAAATCAAAAAAAAATAAGAACTGATAAACACAAACTCAAAGAATTAGAAGATAAAATAAAG GAAAATGAAGAGACTATTTTAAAACTTCAAAAAGAATTAAACAATTTTAAAAAAAAAGAAATT TATCAAAAACCCTTAAATGAAGAAACTTTCACTCCAAGCATTACAAGTAAAAATGACGACTTAG AAGAAAATAAGAAATTAAAAAAGGAATATTTAAAGCCCATAGAAAAAAAAGAAAGCCGAGAT CTAGAAGAAAATACTAAAAGCACCCCAAAAACAACTATGATAAAAACAGCAGATTTTCAAATC TACCCTGACATATATCTTAATAATTATAAATTTAAAGAAAAGGGAGATCAATTTGCATTTAAAA AAGAAAACACATACTATATTGAAATAGATCCCACTAACAATTTAAATGAGGCTTTAAAAAATCA TGAAATAATCTCAAAATATAAATTTGAAAAATATTTCATTAACCCTATTCTAAAAAATAAAGAA GAATTTTTTAGAAACTTAATAGAAGTCAAAAATATCCACGAACTAGGAATTATGTATAAAAATC TAAAGCCTGAATTTAAGCAAATAAAAATAATTAAATAA t352.nt (SEQ ID NO:548) TGTATATCATTATTTGGGGCTAATAATAATACAATAAGCTACTCTAGCATTGAAATTCCTCTAG AAGACTTAAGTGAAGAATTTAAAAGTTCTGGGAATAAAAGCGATCAAATAAATACCTCAAAAC ATTTAAACAAAAACATAGTTTCTTATGAAGACCCAAAAAAGGGTAAAGATCTAAAATTGCCAG AAAATATAAGAGACAAAAACTACCCCAAAAAAGAATGGACGAAAATGATCTAAAATCTGTAA TTGAAAATTATGAAAATAAAATTAAAAACATAGAAAAGCTTTTAAAAACCAAAAATCAAAAAA CATCGGAAAATGAAAATAAAAAAATAGAATCAATCGAAAAAAAAGCAAAAAAATATGAAATTT TAACCAATAAATTAAAAAACGAAATAGTAGAAATAAAAAAGCTCCTTAACAAAAAAATCAAGC CTAAAGAAGATGAAAATTACGAAAAAATAAATATTGAAAACATTGAAGAAGAAACTGATGATG ATTTTGAAGACAATTATGAATATAATGATGAAATTGAAGAACAAATGAGGACAATTACCCTTCT AATGAAGGAATAATAAACAATCTAAAAGAAAATCTTAATGAAAACGAAAAATATTATGCTATT AATGAAAAAAAAATCGATGAACTTGAAGACAGAATCAACGAGAATGAAAACACTATTTTAGAC TTGCAAAGAGAATTAAGGAATTTTAAAAAAAAAGATAACTCAGATAAAAACTTAGAAGAAATT GAGGAAAATTTATCTTCAATAGGAAGAATAATTAATGATCTAAAAAGAAAAATCAGCGCAAAT GAAGCAATAAACAAAGAAAATCAAAAAAAAATAAGAACTGATAAACACAAACTCAAAGAATTA GAAGATAAAATAAAGGAAAATGAAGAGACTATTTTAAAACTTCAAAAAGAATTAAACAATTTT AAAAAAAAAGAAATTTATCAAAAACCCTTAAATGAAGAAACTTTCACTCCAAGCATTACAAGTA AAAATGACGACTTAGAAGAAAATAAGAAATTAAAAAAGGAATATTTAAAGCCCATAGAAAAAA AAGAAAGCCGAGATCTAGAAGAAAATACTAAAAGCACCCCAAAAACAACTATGATAAAAACAG CAGATTTTCAAATCTACCCTGACATATATCTTAATAATTATAAATTTAAAGAAAAGGGAGATCA ATTTGCATTTAAAAAAGAAAACACATACTATATTGAAATAGATCCCACTAACAATTTAAATGAG GCTTTAAAAAATCATGAAATAATCTCAAAATATAAATTTGAAAAATATTTCATTAACCCTATTC TAAAAAATAAAGAAGAATTTTTTAGAAACTTAATAGAAGTCAAAAATATCCACGAACTAGGAA TTATGTATAAAAATCTAAAGCCTGAATTTAAGCAAATAAAAATAATTAAATAA f867.aa (SEQ ID NO:549) MNTKGKVVGVNGNLVTIEVEGSVSMNEVLFVKTAGRNLKAEVIRIRGNEVDAQVFELTKGISVGDL VEFTDKLLTVELGPGLLTQVYDGLQNPLPELAIQCGFFLERGVYLRPLNKDKKWNFKKTSKVGDIVI AGDFLGFVIEGTVHHQIMIPFYKRDSYKIVEIVSDGDYSIDEQIAVIEDDSGMRHNITMSFHWPVKVP ITNYKERLIPSEPMLTQTRIIDTFFPVAKGGTFCIPGPFGAGKTVLQQVTSRNADVDVVIIAACGERAG EVVETLKEFPELMDPKTGKSLMDRTCIICNTSSMPVAAREASVYTAITIGEYYRQMGLDILLLADSTS RWAQAMREMSGRLEEIPGEEAFPAYLESVIASFYERAGIVVLNNGDIGSVTVGGSVSPAGGNFEEPV TQATLKVVGAFHGLTRERSDARKFPAISPLESWSKYKGVIDQKKTEYARSFLVKGNEINQMMKVV GEEGISNDDFLIYLKSELLDSCYLQQNSFDSIDAAVSSERQNYMFDIVYNILKTNFEFSDKLQARDFIN ELRQNLLDMNLSSFKDHKFNKLEHALGELINFKKVI t867.aa (SEQ ID NO:550) GRNLKAEVIRIRGNEVDAQVFELTKGISVGDLVEFTDKLLTVELGPGLLTQVYDGLQNPLPELAIQC GFFLERGVYLRPLNKDKKWNFKKTSKVGDIVIAGDFLGFVIEGTVHHQIMIPFYKRDSYKIVEIVSDG DYSIDEQIAVIEDDSGMRHNITMSFHWPVKVPITNYKERLIPSEPMLTQTRIIDTFFPVAKGGTFCIPG PFGAGKTVLQQVTSRNADVDVVIIAACGERAGEVVETLKEFPELMDPKTGKSLMDRTCIICNTSSMP VAAREASVYTAITIGEYYRQMGLDILLLADSTSRWAQAMREMSGRLEEIPGEEAFPAYLESVIASFY ERAGIVVLNNGDIGSVTVGGSVSPAGGNFEEPVTQATLKVVGAFHGLTRERSDARKFPAISPLESWS KYKGVIDQKKTEYARSFLVKGNEINQMMKVVGEEGISNDDFLIYLKSELLDSCYLQQNSFDSIDAAV SSERQNYMFDIVYNILKTNFEFSDKLQARDFINELRQNLLDMNLSSFKDHKFNKLEHALGELINFKK VI f867.nt (SEQ ID NO:551) ATGAATACAAAAGGAAAAGTCGTTGGAGTTAATGGAAACTTAGTTACTATTGAGGTAGAAGGT TCAGTTTCTATGAATGAAGTTTTATTTGTAAAGACTGCTGGTAGGAATTTAAAAGCAGAAGTAA TTCGTATTAGGGGCAATGAAGTTGATGCACAGGTTTTTGAATTGACAAAAGGGATATCTGTTGG AGACCTAGTTGAATTTACAGACAAACTTTTAACAGTTGAACTCGGACCAGGGCTTTTAACTCAA GTATATGATGGGCTTCAAAATCCTTTGCCTGAATTGGCTATTCAATGTGGATTTTTTTTAGAAAG GGGAGTATATTTAAGGCCCTTGAATAAAGATAAAAAGTGGAATTTTAAAAAAACCTCCAAAGT TGGAGATATCGTTATTGCAGGAGATTTTTTAGGTTTTGTAATTGAGGGAACTGTTCACCATCAA ATAATGATTCCATTTTATAAAAGGGATTCTTATAAAATTGTGGAGATTGTAAGTGATGGCGACT ATTCGATTGATGAGCAAATTGCTGTAATTGAAGATGATTCTGGTATGAGGCATAATATTACAAT GTCTTTTCATTGGCCTGTTAAAGTTCCTATTACTAATTATAAGGAACGCCTTATTCCTAGTGAAC CTATGTTGACTCAAACTAGAATTATAGATACATTTTTCCCAGTTGCCAAAGGTGGAACTTTTTGC ATTCCGGGTCCTTTTGGAGCAGGAAAAACGGTTCTTCAGCAGGTTACAAGTCGAAATGCTGATG TTGATGTAGTGATTATTGCAGCTTGTGGTGAGCGAGCAGGAGAAGTGGTAGAAACTCTTAAAG AATTTCCCGAATTAATGGATCCAAAAACCGGCAAATCTTTAATGGACAGGACTTGTATTATTTG TAATACATCTTCAATGCCAGTTGCAGCTAGAGAAGCTTCTGTTTATACTGCTATTACTATTGGTG AGTATTACAGGCAAATGGGCCTTGATATTCTTCTTTTGGCAGATTCAACTTCAAGATGGGCTCA AGCAATGAGAGAAATGTCTGGACGCCTTGAGGAAATTCCTGGCGAGGAGGCTTTTCCGGCATA TCTTGAGTCTGTTATTGCTTCCTTTTATGAAAGGGCAGGTATTGTAGTTCTTAATAATGGGGATA TTGGATCTGTAACAGTTGGTGGCTCTGTAAGTCCTGCTGGTGGTAATTTTGAAGAGCCAGTTAC TCAAGCAACTTTAAAAGTTGTAGGAGCATTTCACGGGCTTACAAGAGAAAGGTCTGATGCTAG GAAATTTCCAGCTATTAGTCCTCTTGAATCTTGGAGTAAATATAAAGGCGTTATTGATCAAAAA AAGACTGAATATGCAAGATCTTTTTTGGTGAAAGGTAATGAAATTAATCAAATGATGAAAGTTG TTGGAGAAGAAGGCATAAGTAACGATGATTTTTTAATTTATTTAAAATCCGAGCTACTTGATTC GTGCTATTTGCAGCAAAATTCATTTGATTCTATTGATGCTGCTGTTAGTTCAGAGCGTCAAAATT ATATGTTTGATATAGTTTATAACATTCTTAAAACTAACTTTGAGTTTTCTGATAAACTTCAAGCA AGAGATTTTATAAATGAGTTAAGGCAAAATCTTTTAGACATGAATCTTTCTTCTTTTAAGGATC ATAAGTTTAATAAATTGGAGCATGCTTTGGGTGAATTGATAAATTTTAAAAAGGTAATTTAG t867.nt (SEQ ID NO:552) GGTAGGAATTTAAAAGCAGAAGTAATTCGTATTAGGGGCAATGAAGTTGATGCACAGGTTTTT GAATTGACAAAAGGGATATCTGTTGGAGACCTAGTTGAATTTACAGACAAACTTTTAACAGTTG AACTCGGACCAGGGCTTTTAACTCAAGTATATGATGGGCTTCAAAATCCTTTGCCTGAATTGGC TATTCAATGTGGATTTTTTTTAGAAAGGGGAGTATATTTAAGGCCCTTGAATAAAGATAAAAAG TGGAATTTTAAAAAAACCTCCAAAGTTGGAGATATCGTTATTGCAGGAGATTTTTTAGGTTTTG TAATTGAGGGAACTGTTCACCATCAAATAATGATTCCATTTTATAAAAGGGATTCTTATAAAAT TGTGGAGATTGTAAGTGATGGCGACTATTCGATTGATGAGCAAATTGCTGTAATTGAAGATGAT TCTGGTATGAGGCATAATATTACAATGTCTTTTCATTGGCCTGTTAAAGTTCCTATTACTAATTA TAAGGAACGCCTTATTCCTAGTGAACCTATGTTGACTCAAACTAGAATTATAGATACATTTTTCC CAGTTGCCAAAGGTGGAACTTTTTGCATTCCGGGTCCTTTTGGAGCAGGAAAAACGGTTCTTCA GCAGGTTACAAGTCGAAATGCTGATGTTGATGTAGTGATTATTGCAGCTTGTGGTGAGCGAGCA GGAGAAGTGGTAGAAACTCTTAAAGAATTTCCCGAATTAATGGATCCAAAAACCGGCAAATCT TTAATGGACAGGACTTGTATTATTTGTAATACATCTTCAATGCCAGTTGCAGCTAGAGAAGCTT CTGTTTATACTGCTATTACTATTGGTGAGTATTACAGGCAAATGGGCCTTGATATTCTTCTTTTG GCAGATTCAACTTCAAGATGGGCTCAAGCAATGAGAGAAATGTCTGGACGCCTTGAGGAAATT CCTGGCGAGGAGGCTTTTCCGGCATATCTTGAGTCTGTTATTGCTTCCTTTTATGAAAGGGCAG GTATTGTAGTTCTTAATAATGGGGATATTGGATCTGTAACAGTTGGTGGCTCTGTAAGTCCTGC TGGTGGTAATTTTGAAGAGCCAGTTACTCAAGCAACTTTAAAAGTTGTAGGAGCATTTCACGGG CTTACAAGAGAAAGGTCTGATGCTAGGAAATTTCCAGCTATTAGTCCTCTTGAATCTTGGAGTA AATATAAAGGCGTTATTGATCAAAAAAAGACTGAATATGCAAGATCTTTTTTGGTGAAAGGTAA TGAAATTAATCAAATGATGAAAGTTGTTGGAGAAGAAGGCATAAGTAACGATGATTTTTTAATT TATTTAAAATCCGAGCTACTTGATTCGTGCTATTTGCAGCAAAATTCATTTGATTCTATTGATGC TGCTGTTAGTTCAGAGCGTCAAAATTATATGTTTGATATAGTTTATAACATTCTTAAAACTAACT TTGAGTTTTCTGATAAACTTCAAGCAAGAGATTTTATAAATGAGTTAAGGCAAAATCTTTTAGA CATGAATCTTTCTTCTTTTAAGGATCATAAGTTTAATAAATTGGAGCATGCTTTGGGTGAATTGA TAAATTTTAAAAAGGTAATTTAG f868.aa (SEQ ID NO:553) MKRVYSKIESIAGNVITVTAQGIKYGELAIVKAKDTSSLAEVIKLDREKVSLQVYGGTRGVSTSDEIK FLGHSMQVSFSDNLLGRIFDGSGNPRDGGPSLDDNLIEIGGPSANPTKRIVPRNMIRTGLPMIDVFNT LVESQKLPIFSVSGEPYNELLIRIALQAEVDLIILGGMGLKHDDYLTFKDSLEKGGALSRAIFFVHTAN DSVVESLTVPDISLSVAEKFALKGKKVLVLLTDMTNFADAMKEISITMEQVPSNRGYPGDLYSQLA YRYEKAIDFEGAGSITILAVTTMPGDDVTHPVPDNTGYITEGQYYLKGGRIEPFGSLSRLKQMVNSR TRDDHRTIMDSMIKLYASSKESVEKKAMGFNMTKWDEKLLKYSNMFESKMMDLSVNIPLEEALDL GWSILASCFSPKETGIKTDLIEKYWPKKETY t868.aa (SEQ ID NO:554) QGIKYGELAIVKAKDTSSLAEVIKLDREKVSLQVYGGTRGVSTSDEIKFLGHSMQVSFSDNL LGRIFDGSGNPRDGGPSLDDNLIEIGGPSANPTKRIVPRNMIRTGLPMIDVFNTLVESQKLPIFSVSGEP YNELLIRIALQAEVDLIILGGMGLKHDDYLTFKDSLEKGGALSRAIFFVHTANDSVVESLTVPDISLSV AEKFALKGKKVLVLLTDMTNFADAMKEISITMEQVPSNRGYPGDLYSQLAYRYEKAIDFEGAGSITI LAVTTMPGDDVTHPVPDNTGYITEGQYYLKGGRIEPFGSLSRLKQMVNSRTRDDHRTIMDSMIKLY ASSKESVEKKAMGFNMTKWDEKLLKYSNMFESKMMDLSVNIPLEEALDLGWSILASCFSPKETGIK TDLIEKYWPKKETY f868.nt (SEQ ID NO:555) ATGAAAAGAGTCTATAGTAAAATAGAGTCTATAGCAGGCAATGTAATAACTGTTACAGCTCAA GGTATTAAGTATGGTGAGCTTGCTATTGTAAAAGCAAAAGATACAAGTTCTCTAGCCGAAGTAA TTAAACTTGATCGAGAAAAAGTTTCTCTTCAGGTTTATGGTGGTACAAGAGGTGTTTCCACGTC AGACGAGATAAAGTTTTTAGGGCATTCAATGCAGGTTTCATTTTCTGACAATTTGTTGGGCAGA ATTTTTGATGGTTCTGGGAATCCTAGAGATGGGGGCCCTTCTCTTGATGATAATTTGATTGAAA TTGGTGGGCCTTCTGCAAATCCTACAAAACGCATTGTTCCTAGAAATATGATAAGGACAGGGCT TCCAATGATAGATGTTTTTAATACTCTTGTTGAATCTCAAAAATTGCCAATTTTTTCTGTTTCTG GTGAGCCTTATAATGAGCTTCTTATAAGAATTGCACTTCAAGCAGAAGTTGATTTAATAATTCT TGGCGGAATGGGACTTAAGCATGATGATTATTTAACTTTTAAAGATTCTTTAGAAAAGGGAGGT GCTTTAAGTAGAGCAATTTTTTTTGTTCATACTGCTAATGATTCTGTTGTTGAATCTTTAACTGT TCCTGATATTTCACTTTCTGTTGCTGAAAAGTTTGCTCTAAAGGGCAAAAAAGTTTTGGTGCTTC TCACAGACATGACAAATTTTGCTGATGCAATGAAAGAAATATCTATTACAATGGAACAAGTGCC TTCTAATAGAGGTTATCCCGGGGATTTGTATTCTCAGCTTGCATATCGTTATGAGAAGGCTATT GACTTTGAAGGCGCAGGATCAATTACAATACTTGCAGTTACAACAATGCCGGGTGACGATGTTA CTCATCCTGTTCCTGACAATACTGGATACATTACAGAAGGTCAATACTATTTAAAAGGTGGCAG AATAGAGCCTTTTGGGTCTCTTTCAAGACTTAAGCAAATGGTAAATAGTAGAACTAGAGACGAT CACAGGACTATAATGGATTCAATGATCAAGCTTTATGCATCTTCAAAAGAGTCTGTAGAAAAAA AGGCTATGGGATTTAATATGACTAAGTGGGATGAAAAATTGCTCAAGTATAGCAATATGTTTGA AAGTAAGATGATGGATTTGTCTGTTAATATTCCTTTAGAAGAGGCTTTAGATTTAGGTTGGAGC ATTCTTGCTAGTTGTTTTAGCCCAAAAGAAACGGGAATAAAAACAGATCTTATTGAAAAATATT GGCCTAAAAAAGAGACTTATTGA t868.nt (SEQ ID NO:556) CAAGGTATTAAGTATGGTGAGCTTGCTATTGTAAAAGCAAAAGATACAAGTTCTCTAGCCGAAG TAATTAAACTTGATCGAGAAAAAGTTTCTCTTCAGGTTTATGGTGGTACAAGAGGTGTTTCCAC GTCAGACGAGATAAAGTTTTTAGGGCATTCAATGCAGGTTTCATTTTCTGACAATTTGTTGGGC AGAATTTTTGATGGTTCTGGGAATCCTAGAGATGGGGGCCCTTCTCTTGATGATAATTTGATTG AAATTGGTGGGCCTTCTGCAAATCCTACAAAACGCATTGTTCCTAGAAATATGATAAGGACAGG GCTTCCAATGATAGATGTTTTTAATACTCTTGTTGAATCTCAAAAATTGCCAATTTTTTCTGTTT CTGGTGAGCCTTATAATGAGCTTCTTATAAGAATTGCACTTCAAGCAGAAGTTGATTTAATAAT TCTTGGCGGAATGGGACTTAAGCATGATGATTATTTAACTTTTAAAGATTCTTTAGAAAAGGGA GGTGCTTTAAGTAGAGCAATTTTTTTTGTTCATACTGCTAATGATTCTGTTGTTGAATCTTTAAC TGTTCCTGATATTTCACTTTCTGTTGCTGAAAAGTTTGCTCTAAAGGGCAAAAAAGTTTTGGTGC TTCTCACAGACATGACAAATTTTGCTGATGCAATGAAAGAAATATCTATTACAATGGAACAAGT GCCTTCTAATAGAGGTTATCCCGGGGATTTGTATTCTCAGCTTGCATATCGTTATGAGAAGGCT ATTGACTTTGAAGGCGCAGGATCAATTACAATACTTGCAGTTACAACAATGCCGGGTGACGATG TTACTCATCCTGTTCCTGACAATACTGGATACATTACAGAAGGTCAATACTATTTAAAAGGTGG CAGAATAGAGCCTTTTGGGTCTCTTTCAAGACTTAAGCAAATGGTAAATAGTAGAACTAGAGAC GATCACAGGACTATAATGGATTCAATGATCAAGCTTTATGCATCTTCAAAAGAGTCTGTAGAAA AAAAGGCTATGGGATTTAATATGACTAAGTGGGATGAAAAATTGCTCAAGTATAGCAATATGTT TGAAAGTAAGATGATGGATTTGTCTGTTAATATTCCTTTAGAAGAGGCTTTAGATTTAGGTTGG AGCATTCTTGCTAGTTGTTTTAGCCCAAAAGAAACGGGAATAAAAACAGATCTTATTGAAAAAT ATTGGCCTAAAAAAGAGACTTATTGA f872.aa (SEQ ID NO:557) MRSAVLFFFALPFSISLYSSSNKNFPYWILLEKGRQFLYSKSEFSKSNLTHAINYLQEALLRK GVYPEASYYLSVAYGMSGNAILEKLNLYKSFEDRYYLLDESFEKKILFSLAKMAELENNYVDTIDYL NDILNKFSTKKDYYSYHDYSQGENSMSNNELNASFYLTSYLKQVRGAFGIDFTFNLYRFKNYNVID THQLLSKVYLHLKAYELSITHGLIAAVGILTRMYDYVCYYEPVYQFKNLRSFVQKINKYKAIKNAFE STDFWEIVYNVAAATYAYSNGNYKFRAIDTWKLVVDLAPRFSPYIAKSRSQIKNSVYLKKN t872.aa (SEQ ID NO:558) SNKNFPYWILLEKGRQFLYSKSEFSKSNLTHAINYLQEALLRKGVYPEASYYLSVAYGMSGNAILEK LNLYKSFEDRYYLLDESFEKKILFSLAKMAELENNYVDTIDYLNDILNKFSTKKDYYSYHPYSQGEN SMSNNELNASFYLTSYLKQVRGAFGIDFTFNLYRFKNYNVIDTHQLLSKVYLHLKAYELSITHGLIA AVGILTRMYDYVCYYEPVYQFKNLRSFVQKINKYKAIKNAFESTDFWEIVYNVAAATYAYSNGNY KFRAIDTWKLVVDLAPRFSPYIAKSRSQIKNSVYLKKN f872.nt (SEQ ID NO:559) ATGAGAAGTGCGGTTTTATTTTTTTTTGCTTTGCCTTTTTCTATTTCTTTGTATTCTTCAAGTAAT AAAAATTTTCCGTATTGGATTTTACTTGAAAAAGGCAGGCAATTTCTTTATTCTAAATCTGAATT TAGTAAGTCTAATCTTACACATGCTATTAATTATTTGCAGGAAGCTTTGCTTAGAAAAGGCGTT TATCCTGAGGCTAGTTATTATTTGTCAGTAGCTTATGGTATGTCTGGCAATGCTATTCTTGAAAA ATTAAACCTTTATAAGTCTTTTGAAGACAGATATTATTTGCTAGATGAATCTTTTGAAAAAAAA ATACTTTTTTCTTTAGCTAAAATGGCTGAACTTGAGAATAATTATGTTGATACTATTGATTATTT GAATGACATATTAAATAAGTTTTCAACTAAAAAAGATTATTATAGTTATCATGATTATTCTCAA GGCGAAAACAGTATGTCAAATAATGAACTTAATGCTTCATTTTATTTAACTTCTTATTTAAAACA AGTAAGAGGAGCTTTTGGTATTGATTTTACTTTTAATCTTTACAGATTTAAAAACTACAATGTTA TTGATACTCATCAATTATTGTCAAAAGTTTATTTGCACTTAAAAGCTTATGAGCTTTCAATTACT CATGGACTTATAGCTGCAGTAGGAATTTTAACAAGAATGTATGATTATGTTTGTTATTATGAAC CTGTGTATCAGTTTAAAAATTTAAGGTCTTTTGTTCAAAAAATTAATAAGTATAAGGCAATAAA AAATGCTTTTGAATCTACAGATTTTTGGGAAATAGTTTATAATGTTGCTGCTGCTACTTATGCAT ATTCTAATGGCAATTATAAATTTAGAGCAATAGATACTTGGAAATTAGTAGTAGATCTTGCGCC AAGGTTTTCTCCTTATATTGCTAAATCAAGAAGTCAAATTAAAAATTCTGTATATTTAAAAAAA AATTAA t872.nt (SEQ ID NO:560) AGTAATAAAAATTTTCCGTATTGGATTTTACTTGAAAAAGGCAGGCAATTTCTTTATTCTAAATC TGAATTTAGTAAGTCTAATCTTACACATGCTATTAATTATTTGCAGGAAGCTTTGCTTAGAAAA GGCGTTTATCCTGAGGCTAGTTATTATTTGTCAGTAGCTTATGGTATGTCTGGCAATGCTATTCT TGAAAAATTAAACCTTTATAAGTCTTTTGAAGACAGATATTATTTGCTAGATGAATCTTTTGAA AAAAAAATACTTTTTTCTTTAGCTAAAATGGCTGAACTTGAGAATAATTATGTTGATACTATTG ATTATTTGAATGACATATTAAATAAGTTTTCAACTAAAAAAGATTATTATAGTTATCATGATTAT TCTCAAGGCGAAAACAGTATGTCAAATAATGAACTTAATGCTTCATTTTATTTAACTTCTTATTT AAAACAAGTAAGAGGAGCTTTTGGTATTGATTTTACTTTTAATCTTTACAGATTTAAAAACTAC AATGTTATTGATACTCATCAATTATTGTCAAAAGTTTATTTGCACTTAAAAGCTTATGAGCTTTC AATTACTCATGGACTTATAGCTGCAGTAGGAATTTTAACAAGAATGTATGATTATGTTTGTTAT TATGAACCTGTGTATCAGTTTAAAAATTTAAGGTCTTTTGTTCAAAAAATTAATAAGTATAAGG CAATAAAAAATGCTTTTGAATCTACAGATTTTTGGGAAATAGTTTATAATGTTGCTGCTGCTACT TATGCATATTCTAATGGCAATTATAAATTTAGAGCAATAGATACTTGGAAATTAGTAGTAGATC TTGCGCCAAGGTTTTCTCCTTATATTGCTAAATCAAGAAGTCAAATTAAAAATTCTGTATATTTA AAAAAAAATTAA f874.aa (SEQ ID NO:561) MLKSNKVVLIGAGGVGSSFAYALTIDNSLVHELVIIDVNENKAKGEVMDLNHGQMFLKKNINVLFG TYKDCANADIVVITAGLNQKPGETRLDLVDKNSKIFKDIITNVVSSGFDGIFVVASNPVDIMTYVTM KYSKFPIHKVIGTGTILDTSRLRYFLSDHFNVNTQNIHSYIMGEHXDSSFATWDETKIAMKPLSEYLA EGKITELELDEIHKKVVNAAYEVIKLKGATYYAIGLGIKNIVNAIIGDQNVILPISSYINGQYGGLIKDI YIGAPAIVCKEGVKEVLNFKISPKELDKFNSSANQLKSYIDKMEF t874.aa (SEQ ID NO:562) ALTIDNSLVHELVIIDVNENKAKGEVMDLNHGQMFLKKNINVLFGTYKDCANADIVVITAGLNQKP GETRLDLVDKNSKIFKDIITNVVSSGFDGIFVVASNPVDIMTYVTMKYSKFPIHKVIGTGTILDTSRLR YFLSDHFNVNTQNIHSYIMGEHXDSSFATWDETKIAMKPLSEYLAEGKITELELDEIHKKVVNAAYE VIKLKGATYYAIGLGIKNIVNAIIGDQNVILPISSYINGQYGGLIKDIYIGAPAIVCKEGVKEVLNFKISP KELDKFNSSANQLKSYIDKMEF f874.nt (SEQ ID NO:563) ATGCCTAAGTCTAATAAAGTTGTTCTTATTGGAGCTGGTGGGGTTGGTTCAAGCTTTGCGTATG CTTTAACAATAGACAATTCACTTGTACATGAACTTGTAATTATTGATGTTAATGAAAATAAAGC AAAAGGGGAGGTCATGGACCTTAATCATGGCCAAATGTTTTTAAAGAAGAATATTAATGTATTG TTTGGGACTTACAAAGATTGTGCTAATGCAGATATTGTTGTAATTACAGCAGGACTTAATCAAA AGCCTGGTGAGACAAGACTTGATTTGGTTGATAAAAATTCTAAAATTTTTAAAGATATTATAAC TAATGTTGTATCTAGCGGTTTTGATGGTATTTTTGTTGTTGCAAGCAATCCTGTAGACATTATGA CTTATGTTACAATGAAATATTCCAAATTTCCTATTCATAAGGTTATTGGTACTGGGACTATTCTT GATACTTCAAGACTTAGATATTTTTTAAGTGATCATTTTAATGTGAACACTCAAAATATACATTC ATATATTATGGGTGAGCACGTGACAGTTCTTTTGCTACGTGGGATGAAACAAAAATAGCAATGA AGCCTTTGTCAGAATATCTTGCTGAAGGCAAAATAACTGAGTTGGAGCTTGATGAAATTCATAA AAAGGTTGTGAATGCTGCTTATGAAGTTATTAAGTTAAAGGGGGCAACCTATTATGCTATTGGA CTTGGTATTAAGAATATTGTAAATGCAATAATTGGAGATCAGAATGTTATTCTGCCAATATCTT CTTATATTAATGGCCAGTATGGGGGATTGATTAAAGATATTTATATTGGAGCGCCTGCTATAGT TTGTAAGGAAGGAGTCAAAGAAGTTTTAAACTTTAAGATAAGCCCTAAAGAGCTTGATAAGTTT AATAGTTCTGCTAATCAGCTTAAAAGCTATATTGATAAAATGGAATTTTAG t874.nt (SEQ ID NO:564) GCTTTAACAATAGACAATTCACTTGTACATGAACTTGTAATTATTGATGTTAATGAAAATAAAG CAAAAGGGGAGGTCATGGACCTTAATCATGGCCAAATGTTTTTAAAGAAGAATATTAATGTATT GTTTGGGACTTACAAAGATTGTGCTAATGCAGATATTGTTGTAATTACAGCAGGACTTAATCAA AAGCCTGGTGAGACAAGACTTGATTTGGTTGATAAAAATTCTAAAATTTTTAAAGATATTATAA CTAATGTTGTATCTAGCGGTTTTGATGGTATTTTTGTTGTTGCAAGCAATCCTGTAGACATTATG ACTTATGTTACAATGAAATATTCCAAATTTCCTATTCATAAGGTTATTGGTACTGGGACTATTCT TGATACTTCAAGACTTAGATATTTTTTAAGTGATCATTTTAATGTGAACACTCAAAATATACATT CATATATTATGGGTGAGCACGTGACAGTTCTTTTGCTACGTGGGATGAAACAAAAATAGCAATG AAGCCTTTGTCAGAATATCTTGCTGAAGGCAAAATAACTGAGTTGGAGCTTGATGAAATTCATA AAAAGGTTGTGAATGCTGCTTATGAAGTTATTAAGTTAAAGGGGGCAACCTATTATGCTATTGG ACTTGGTATTAAGAATATTGTAAATGCAATAATTGGAGATCAGAATGTTATTCTGCCAATATCT TCTTATATTAATGGCCAGTATGGGGGATTGATTAAAGATATTTATATTGGAGCGCCTGCTATAG TTTGTAAGGAAGGAGTCAAAGAAGTTTTAAACTTTAAGATAAGCCCTAAAGAGCTTGATAAGTT TAATAGTTCTGCTAATCAGCTTAAAAGCTATATTGATAAAATGGAATTTTAG f886.aa (SEQ ID NO:565) MKKKQLILLLFMPQIIYAKSYFASDVFFNKYQKLNEKPKTGFYIEYYSVDDTEKLYLYKENNLIKYK TIQIIENTKKITCYDTKDTKRKEEIYDNLNNKIQEIEYDSKGKTLETANYVYENENLISKNLKTINQKP KLIYYSKDDNGKLLKITGSNFQIWNYGINGDIKSTYFDIKKATTKVIKYDDKKRNSNSTIIVNNKIKS KEKNQYLDEEKIVNTFEEENTKIISTYKANNLIKEETYKNNELIKVNDFQYNESDMIIFQNTKEKDKD QYTNTKIEYEYNKDNQLKSKKIYENDIIYLKTEYHNDNEYEEEIYYKKPALRVKHKNGKVTEEKPI GTN t886.aa (SEQ ID NO:566) SYFASDVFFNKYQKLNEKPKTGFYIEYYSVDDTEKLYLYKENNLIKYKTIQIIENTKKITCYDTKDTK RKEEIYDNLNNKIQEIEYDSKGKTLETANYVYENENLISKNLKTINQKPKLIYYSKDDNGKLLKITGS NFQIWNYGINGDIKSTYFDIKKATTKVIKYDDKKRNSNSTIIVNNKIKSKEKNQYLDEEKIVNTFEEE NTKIISTYKANNLIKEETYKNNELIKVNDFQYNESDMIIFQNTKEKDKDQYTNTKIEYEYNKDNQLK SKKIYENDIIYLKTEYHNDNEYEEEIYYNKKPALRVKHKNGKVTEEKPIGTN f886.nt (SEQ ID NO:567) ATGAAAAAAAAACAATTAATACTTCTTCTATTTATGCCACAAATTATTTATGCAAAAAGCTATT TTGCATCTGATGTATTTTTCAATAAATACCAAAAATTAAATGAAAAACCAAAAACGGGGTTTTA TATTGAGTATTATTCTGTTGATGATACTGAAAAACTCTACCTATACAAAGAAAATAACTTAATA AAATACAAAACAATTCAAATCATAGAAAACACAAAAAAAATTACATGTTATGATACAAAAGAT ACAAAAAGAAAAGAAGAGATTTACGATAATTTAAATAACAAAATACAAGAAATTGAATATGAT AGCAAAGGAAAAACTCTTGAAACAGCAAATTACGTTTATGAAAACGAAAACTTAATATCTAAA AATTTAAAAACAATAAACCAAAAACCAAAATTAATATATTATTCTAAAGACGACAATGGTAAAT TACTAAAAATAACAGGATCAAATTTCCAAATTTGGAACTATGGAATTAATGGCGACATAAAATC TACATATTTTGACATCAAAAAAGCAACAACAAAAGTTATAAAATATGATGATAAAAAAAGAAA TTCAAACAGTACAATAATTGTTAATAATAAAATAAAATCCAAAGAAAAAAACCAATATTTAGAT GAAGAAAAAATAGTAAATACCTTTGAAGAAGAGAATACAAAAATCATATCTACCTACAAGGCA AACAACCTAATTAAAGAAGAAACATATAAAAATAATGAACTTATAAAAGTAAATGATTTTCAAT ACAACGAATCTGATATGATAATTTTTCAAAACACTAAAGAAAAGGATAAAGACCAATACACCA ATACTAAAATTGAATACGAATATAACAAAGACAATCAATTAAAAAGCAAAAAAATTTATGAGA ACGATATAATTTATCTAAAAACTGAATACCACAATGACAATGAATATGAAGAAGAAATATACTA CAATAAAAAACCTGCTCTTAGGGTAAAACACAAGAACGGAAAAGTCACCGAAGAAAAACCAAT AGGAACAAATTAA t886.nt (SEQ ID NO:568) AGCTATTTTGCATCTGATGTATTTTTCAATAAATACCAAAAATTAAATGAAAAACCAAAAACGG GGTTTTATATTGAGTATTATTCTGTTGATGATACTGAAAAACTCTACCTATACAAAGAAAATAA CTTAATAAAATACAAAACAATTCAAATCATAGAAAACACAAAAAAAATTACATGTTATGATACA AAAGATACAAAAAGAAAAGAAGAGATTTACGATAATTTAAATAACAAAATACAAGAAATTGAA TATGATAGCAAAGGAAAAACTCTTGAAACAGCAAATTACGTTTATGAAAACGAAAACTTAATA TCTAAAAATTTAAAAACAATAAACCAAAAACCAAAATTAATATATTATTCTAAAGACGACAATG GTAAATTACTAAAAATAACAGGATCAAATTTCCAAATTTGGAACTATGGAATTAATGGCGACAT AAAATCTACATATTTTGACATCAAAAAAGCAACAACAAAAGTTATAAAATATGATGATAAAAA AAGAAATTCAAACAGTACAATAATTGTTAATAATAAAATAAAATCCAAAGAAAAAAACCAATA TTTAGATGAAGAAAAAATAGTAAATACCTTTGAAGAAGAGAATACAAAAATCATATCTACCTA CAAGGCAAACAACCTAATTAAAGAAGAAACATATAAAAATAATGAACTTATAAAAGTAAATGA TTTTCAATACAACGAATCTGATATGATAATTTTTCAAAACACTAAAGAAAAGGATAAAGACCAA TACACCAATACTAAAATTGAATACGAATATAACAAAGACAATCAATTAAAAAGCAAAAAAATT TATGAGAACGATATAATTTATCTAAAAACTGAATACCACAATGACAATGAATATGAAGAAGAA ATATACTACAATAAAAAACCTGCTCTTAGGGTAAAACACAAGAACGGAAAAGTCACCGAAGAA AAACCAATAGGAACAAATTAA f888.aa (SEQ ID NO:569) MEKLKLKLAIPLLVFTICKIHSQSNIEYNFSYIINTKKENIDLKKGIEKQLDKIYDKITEHIVNNDDKSII EDIYINQDIIKTELEISKLKKEMDKKKLQNIITAKEKHNTKTKIDELKKNIQNINNKQKKFAEYFNNL KKLKVKYKKIEEQTNISNLNKEFFIREELFFINYIDLKKIENYYLLEISNITPEKIETKKAVFKTSSSVNE IADHITKYSLKEILGREFLKININVKNNSDAKIYINEKFVSKGIYHDNIFDISKLPNKEIEIQITSANFEN YSIKRTVKNADSIILDIDLKRTISKKVSIKSNVQSKVFKKGIFMGETPIEIEKPENQDIILLKSKGYKDK FKLINKEEDQVEIEMIKTNKNRLIDTRDKFYVNLAVFFLSTTGAIFAGTLLNNSEVLYKITGNHFINKR LTAEDVYMAKAEQMTATFLFGVGITLTTGSFISLITHLVEYIKEANMGE t888.aa (SEQ ID NO:570) SNIEYNFSYIINTKKENIDLKKGIEKQLDKIYDKITEHIVNNDDKSIIEDIYINQDIIKTELEISKLKKEM DKKKLQNIITAKEKHNTKTKIDELKKNIQNINNKQKKFAEYFNNLKKLKVKYKKIEEQTNISNLNKE FFIREELFFINYIDLKKIENYYLLEISNITPEKIETKKAVFKTSSSVNEIADHITKYSLKEILGREFLKININ VKNNSDAKIYINEKFVSKGIYHDNIFDISKLPNKEIEIQITSANFENYSIKRTVKNADSIILDIDLKRTIS KKVSIKSNVQSKVFKKGIFMGETPIEIEKPENQDIILLKSKGYKDKFKLINKEEDQVEIEMIKTNKNRL IDTRDKFYVNLAVFFLSTIGAIFAGTLLNNSEVLYKITGNHFINKRLTAEDVYMAKAEQMTATFLFG VGITLTIGSFISLITHLVEYIKEANMGE f888.nt (SEQ ID NO:571) ATGGAAAAGCTTAAACTAAAGCTAGCAATACCATTGCTAGTATTTACAATATGCAAAATACATT CTCAAAGTAATATTGAATACAATTTTTCCTATATCATTAATACAAAAAAAGAAAATATTGACCT AAAAAAGGGTATTGAAAAACAATTGGACAAAATCTATGATAAAATAACAGAACATATAGTAAA CAATGATGACAAGAGCATCATTGAAGACATTTATATAAATCAAGATATAATAAAAACAGAACT TGAAATTAGCAAATTAAAAAAAGAAATGGATAAAAAAAAACTTCAAAACATAATAACCGCAAA AGAAAAGCATAACACCAAAACCAAAATTGATGAGCTTAAAAAAAATATTCAAAATATTAACAA TAAACAAAAAAAATTTGCAGAATATTTTAACAATTTAAAAAAACTAAAAGTAAAATATAAAAA AATCGAAGAGCAAACAAATATATCAAATTTAAATAAAGAATTTTTTATAAGAGAAGAATTATTT TTTATTAACTATATTGATCTTAAAAAAATAGAAAATTATTATTTGCTAGAAATTAGCAACATCA CTCCTGAGAAAATTGAGACTAAAAAAGCGGTATTTAAAACATCATCTTCTGTTAATGAAATTGC AGATCACATAACAAAATACAGCCTCAAAGAAATATTGGGCAGAGAATTTTTAAAAATCAACATT AACGTCAAAAATAACTCGGATGCAAAAATCTACATAAATGAAAAATTTGTTTCAAAAGGAATCT ATCACGATAATATTTTTGACATTTCTAAACTCCCAAACAAAGAAATTGAAATACAAATCACAAG TGCAAATTTCGAAAACTATTCTATTAAAAGAACGGTAAAAAATGCAGACTCAATAATATTAGAT ATTGACTTAAAAAGAACAATCTCTAAAAAAGTATCAATTAAAAGCAATGTACAATCTAAAGTTT TTAAAAAAGGAATATTTATGGGAGAAACCCCAATTGAAATTGAAAAACCAGAAAATCAAGATA TCATCTTGCTTAAATCTAAAGGATATAAAGATAAATTCAAGTTAATAAATAAAGAAGAAGATCA AGTAGAAATAGAAATGATAAAAACTAACAAAAATAGACTTATCGACACAAGAGATAAATTTTA TGTCAATCTGGCCGTCTTTACATTAAGCACAATAGGAGCCATTTTTGCAGGAACATTGCTTAAC AATTCAGAAGTACTTTATAAAATAACAGGCAATCACTTTATTAACAAAAGATTAACAGCAGAAG ATGTTTATATGGCAAAAGCGGAACAAATGACTGCAACATTTCTATTTGGAGTAGGAATCACTTT AACTATTGGAAGCTTTATCTCATTAATAACTCATTTAGTAGAATATATTAAAGAAGCAAATATG GGAGAATAG t888.nt (SEQ ID NO:572) AGTAATATTGAATACAATTTTTCCTATATCATTAATACAAAAAAAGAAAATATTGACCTAAAAA AGGGTATTGAAAAACAATTGGACAAAATCTATGATAAAATAACAGAACATATAGTAAACAATG ATGACAAGAGCATCATTGAAGACATTTATATAAATCAAGATATAATAAAAACAGAACTTGAAA TTAGCAAATTAAAAAAAGAAATGGATAAAAAAAAACTTCAAAACATAATAACCGCAAAAGAAA AGCATAACACCAAAACCAAAATTGATGAGCTTAAAAAAAATATTCAAAATATTAACAATAAAC AAAAAAAATTTGCAGAATATTTTAACAATTTAAAAAAACTAAAAGTAAAATATAAAAAAATCG AAGAGCAAACAAATATATCAAATTTAAATAAAGAATTTTTTATAAGAGAAGAATTATTTTTTAT TAACTATATTGATCTTAAAAAAATAGAAAATTATTATTTGCTAGAAATTAGCAACATCACTCCT GAGAAAATTGAGACTAAAAAAGCGGTATTTAAAACATCATCTTCTGTTAATGAAATTGCAGATC ACATAACAAAATACAGCCTCAAAGAAATATTGGGCAGAGAATTTTTAAAAATCAACATTAACGT CAAAAATAACTCGGATGCAAAAATCTACATAAATGAAAAATTTGTTTCAAAAGGAATCTATCAC GATAATATTTTTGACATTTCTAAACTCCCAAACAAAGAAATTGAAATACAAATCACAAGTGCAA ATTTCGAAAACTATTCTATTAAAAGAACGGTAAAAAATGCAGACTCAATAATATTAGATATTGA CTTAAAAAGAACAATCTCTAAAAAAGTATCAATTAAAAGCAATGTACAATCTAAAGTTTTTAAA AAAGGAATATTTATGGGAGAAACCCCAATTGAAATTGAAAAACCAGAAAATCAAGATATCATC TTGCTTAAATCTAAAGGATATAAAGATAAATTCAAGTTAATAAATAAAGAAGAAGATCAAGTA GAAATAGAAATGATAAAAACTAACAAAAATAGACTTATCGACACAAGAGATAAATTTTATGTC AATCTGGCCGTCTTTACATTAAGCACAATAGGAGCCATTTTTGCAGGAACATTGCTTAACAATT CAGAAGTACTTTATAAAATAACAGGCAATCACTTTATTAACAAAAGATTAACAGCAGAAGATGT TTATATGGCAAAAGCGGAACAAATGACTGCAACATTTCTATTTGGAGTAGGAATCACTTTAACT ATTGGAAGCTTTATCTCATTAATAACTCATTTAGTAGAATATATTAAAGAAGCAAATATGGGAG AATAG f893.aa (SEQ ID NO:573) MVRFLGFLYLITTIPLIKSCDAAQFGDYKPLYFENENDLKTANEYINSLGYKTISEYTTKIDILDFPEN KEITINEINKLNNLDLRKSIFLKKLSNLFNIEHKKLLYVENRFKSINFKNLKKELNINADIHSLDYKTKI NFISSIIFLIIIILLIFLDPTNSIFTLIFLLISSLAFMISKEIMYFYPFTVLSYLLFLIISNFNKNYNKIYLKEINF LTLMTKIKHLLFLFTFTALYFITITTFFTTNIDPTFIAFVAIPTLCIFLIFSWIKTESNFKDTFLFPIEIKEK KIEGKKALKSKIAIHLLLFTLSLIPFAYSSYMLNSYENINYLYSKKLNYFDYLNPNNIYIMLGYNKDM PNIIGYLSHILYQNELKYNITAKYGKIPKDIKENYFEIKNDKIEIHPKTVYEVDKSFIDEILKKDLASLF LKNKNPILIYKENKNNINTDKKNYKILFFFSLPFFVLLFLFKAIRFTILLNIN EKTYKKYIQG t893.aa (SEQ ID NO:574) CDAAQFGDYKPLYFENENDLKTANEYINSLGYKTISEYTTKIDILDFPENKEITINEINKLNNLDLRKS IFLKKLSNLFNIEHKKLLYVENRFKSINFKNLKKELNINADIHSLDYKTKINFISSIIFLIIIILLIFLDPTNS IFTLIFLLISSLAFMISKEIMYFYPFTVLSYLLFLIISNFNKNYNKIYLKEINFLTLMTKIKHLLFLFTFTA LYFITITTFFTTNIDPTFIAFVAIPTLCIFLIFSWIKTESNFKDTFLFPIEIKEKKIEGKKALKSKIAIHLLLF TLSLIPFAYSSYMLNSYENINYLYSKKLNYFDYLNPNNIYIMLGYNKDMPNIIGYLSHILYQNELKYN ITAKYGKIPKDIKENYFEIKNDKIEIHPKTVYEVDKSFIDEILKKDLASLFLKNKNPILIYKENKNNINT DKKNYKILFFFSLPFFVLLFLFKAIRFTILLNLNEKTYKKYIQG f893.nt (SEQ ID NO:575) ATGGTGCGTTTTTTAGGTTTTTTATATTTAATTACAACAATACCACTTATCAAATCCTGTGATGC AGCTCAATTTGGAGACTACAAACCTTTATACTTTGAAAATGAAAATGATCTAAAAACTGCCAAT GAATATATAAATTCACTAGGATACAAAACAATCTCAGAATACACAACAAAAATTGACATTTTAG ACTTTCCCGAAAATAAAGAAATCACAATAAATGAGATAAACAAACTTAACAATCTTGACCTGAG AAAAAGCATATTTTTAAAAAAGCTCTCCAATCTTTTCAACATAGAGCACAAAAAACTTCTTTAT GTTGAAAACAGGTTTAAAAGTATAAATTTTAAAAACCTAAAAAAAGAACTCAATATTAATGCCG ACATACATTCTCTTGACTACAAAACAAAAATTAATTTTATTTCAAGCATAATATTTCTAATCATA ATAATTTTATTAATTTTTTTAGACCCAACAAACTCTATATTTACTTTAATTTTTCTATTAATTTCA TCTCTTGCTTTTATGATAAGCAAAGAAATAATGTATTTTTATCCATTTACAGTTCTCTCTTATTT GTTATTTTTAATAATCAGTAATTTTAACAAAAATTACAATAAAATATATTTAAAAGAAATAAAT TTTTTAACACTAATGACAAAAATAAAACACTTACTATTTTTATTTACATTCACAGCTCTATATTT CATTACAATCACAACCTTTTTTACTACAAATATTGATCCCACTTTTATTGCATTTGTCGCAATAC CAACCCTTTGCATTTTCTTAATTTTCAGCTGGATAAAAACAGAAAGCAATTTTAAAGACACTTTC TTATTCCCAATCGAGATTAAAGAGAAAAAAATAGAAGGAAAAAAAGCTTTAAAATCAAAAATA GCAATACATCTACTACTATTTACACTCTCATTAATTCCTTTCGCTTATTCAAGCTATATGCTAAA TTCTTATGAAAACATTAACTACCTTTACAGTAAAAAATTAAATTACTTTGATTATTTAAATCCTA ATAACATTTATATAATGCTGGGATACAACAAAGACATGCCCAATATTATAGGGTACCTATCCCA CATTCTTTATCAAAACGAACTAAAATACAATATTACCGCTAAGTATGGAAAAATTCCTAAAGAT ATAAAAGAAAATTACTTTGAAATCAAAAACGACAAAATAGAAATTCATCCTAAAACTGTTTACG AAGTAGACAAATCATTTATTGATGAAATTCTTAAAAAAGATCTTGCAAGTCTGTTTTTAAAAAA TAAAAATCCAATCCTAATATATAAAGAAAACAAGAATAATATCAACACAGATAAAAAAAATTA CAAAATACTTTTCTTTTTCTCTTTGCCCTTCTTTGTATTACTATTCCTATTTAAAGCAATAAGATT TACAATTCTTTTAAACATAAATGAAAAAACCTATAAAAAATATATTCAAGGATAA t893.nt (SEQ ID NO:576) TGTGATGCAGCTCAATTTGGAGACTACAAACCTTTATACTTTGAAAATGAAAATGATCTAAAAA CTGCCAATGAATATATAAATTCACTAGGATACAAAACAATCTCAGAATACACAACAAAAATTGA CATTTTAGACTTTCCCGAAAATAAAGAAATCACAATAAATGAGATAAACAAACTTAACAATCTT GACCTGAGAAAAAGCATATTTTTAAAAAAGCTCTCCAATCTTTTCAACATAGAGCACAAAAAAC TTCTTTATGTTGAAAACAGGTTTAAAAGTATAAATTTTAAAAACCTAAAAAAAGAACTCAATAT TAATGCCGACATACATTCTCTTGACTACAAAACAAAAATTAATTTTATTTCAAGCATAATATTTC TAATCATAATAATTTTATTAATTTTTTTAGACCCAACAAACTCTATATTTACTTTAATTTTTCTAT TAATTTCATCTCTTGCTTTTATGATAAGCAAAGAAATAATGTATTTTATCCATTTACAGTTCTC TCTTATTTGTTATTTTTAATAATCAGTAATTTTAACAAAAATTACAATAAAATATATTTAAAAGA AATAAATTTTTTAACACTAATGACAAAAATAAAACACTTACTATTTTTATTTACATTCACAGCTC TATATTTCATTACAATCACAACCTTTTTTACTACAAATATTGATCCCACTTTTATTGCATTTGTCG CAATACCAACCCTTTGCATTTTCTTAATTTTCAGCTGGATAAAAACAGAAAGCAATTTTAAAGA CACTTTCTTATTCCCAATCGAGATTAAAGAGAAAAAAATAGAAGGAAAAAAAGCTTTAAAATC AAAAATAGCAATACATCTACTACTATTTACACTCTCATTAATTCCTTTCGCTTATTCAAGCTATA TGCTAAATTCTTATGAAAACATTAACTACCTTTACAGTAAAAAATTAAATTACTTTGATTATTTA AATCCTAATAACATTTATATAATGCTGGGATACAACAAAGACATGCCCAATATTATAGGGTACC TATCCCACATTCTTTATCAAAACGAACTAAAATACAATATTACCGCTAAGTATGGAAAAATTCC TAAAGATATAAAAGAAAATTACTTTGAAATCAAAAACGACAAAATAGAAATTCATCCTAAAAC TGTTTACGAAGTAGACAAATCATTTATTGATGAAATTCTTAAAAAAGATCTTGCAAGTCTGTTT TTAAAAAATAAAAATCCAATCCTAATATATAAAGAAAACAAGAATAATATCAACACAGATAAA AAAAATTACAAAATACTTTTCTTTTTCTCTTTGCCCTTCTTTGTATTACTATTCCTATTTAAAGCA ATAAGATTTACAATTCTTTTAAACATAAATGAAAAAACCTATAAAAAATATATTCAAGGATAA f895.aa (SEQ ID NO:577) MIRALLTNDLFLSCLVSGISAQVIKYGIQTVKTRKLKLTPVHLLKKIFLETGGMPSSHSSTVTALSTSI ALTEGIDTNFIIALAFALITIRDSFGVRYMSGVQAEYLNALSEKLKKEIKIDTTKIKVVKGHKKKEVLT GIIIGIVSAYIVCYF t895.aa (SEQ ID NO:578) AQVIKYGIQTVKTRKLKLTPVHLLKKIFLETGGMPSSHSSTVTALSTSIALTEGIDTNFIIALAFALITIR DSFGVRYMSGVQAEYLNALSEKLKKEIKIDTTKIKVVKGHKKKEVLTGIIIGIVSAYIVCYF f895.nt (SEQ ID NO:579) ATGATAAGGGCATTGCTTACCAATGATCTTTTTTTGTCTTGTCTTGTATCAGGAATTTCTGCTCA AGTGATTAAATATGGTATCCAAACTGTAAAAACAAGAAAGTTAAAACTAACTCCAGTACATCTT TTAAAAAAAATTTTTCTAGAAACAGGAGGCATGCCAAGTAGTCATTCATCAACGGTCACCGCTC TTTCAACCTCAATCGCACTAACTGAAGGAATAGATACAAATTTTATAATAGCTCTTGCATTTGC CCTTATTACAATAAGAGATTCTTTCGGCGTAAGATATATGTCTGGAGTTCAAGCAGAATATTTA AATGCATTATCAGAAAAATTAAAAAAAGAAATAAAAATTGACACAACAAAAATAAAAGTGGTC AAGGGGCACAAAAAGAAGAGGTTCTAACGGGCATAATAATAGGAATAGTCTCTGCGTATATT GTGTGCTATTTTTAG t895.nt (SEQ ID NO:580) GCTCAAGTGATTAAATATGGTATCCAAACTGTAAAAACAAGAAAGTTAAAACTAACTC CAGTACATCTTTTAAAAAAAATTTTTCTAGAAACAGGAGGCATGCCAAGTAGTCATTCATCAAC GGTCACCGCTCTTTCAACCTCAATCGCACTAACTGAAGGAATAGATACAAATTTTATAATAGCT CTTGCATTTGCCCTTATTACAATAAGAGATTCTTTCGGCGTAAGATATATGTCTGGAGTTCAAGC AGAATATTTAAATGCATTATCAGAAAAATTAAAAAAAGAAATAAAAATTGACACAACAAAAAT AAAAGTGGTCAAGGGGCACAAAAAGAAAGAGGTTCTAACGGGCATAATAATAGGAATAGTCTC TGCGTATATTGTGTGCTATTTTTAG f605.aa (SEQ ID NO:581) MYIGAAGKSFSIIIDSAFLSNCFLFIGSFSRSDSLMSLSNSRFEYPYDASCEFSLVNIVKYVCGSKYSPM RPTLIISKLPVFLLLVRTGQFSLVSIRLIFRIFFHWF t605.aa (SEQ ID NO:582) CFLFIGSFSRSDSLMSLSNSRFEYPYDASCEFSLVNIVKYVCGSKYSPMRPTLIISKLPVFLLL VRTGQFSLVSIRLIFRIFFHWF f605.nt (SEQ ID NO:583) ATGTATATTGGTGCAGCAGGAAAATCTTTTTCAATTATTATTGATTCTGCTTTTCTGAGT AATTGTTTTCTTTTTATAGGATCTTTTTCAAGATCTGATTCTCTGATGAGTTTGTCAAATTCTAG GTTTGAATATCCGTATGATGCAAGTTGTGAATTTTCTCTTGTGAATATAGTAAAGTATGTGTGT GGATCTAAATATTCCCCAATGCGTCCAACTCTTATTATTTCAAAATTGCCAGTATTTCTGCTGTT GGTAAGAACAGGCCAATTTTCGTTGGTAAGCATAAGATTGATATTTAGAATTTTTTTCCATTGG TTTTGA t605.nt (SEQ ID NO:584) TGTTTTCTTTTTATAGGATCTTTTTCAAGATCTGATTCTCTGATGAGTTTGTCAAATTCT AGGTTTGAATATCCGTATGATGCAAGTTGTGAATTTTCTCTTGTGAATATAGTAAAGTATGTGT GTGGATCTAAATATTCCCCAATGCGTCCAACTCTTATTATTTCAAAATTGCCAGTATTTCTGCTG TTGGTAAGAACAGGCCAATTTTCGTTGGTAAGCATAAGATTGATATTTAGAATTTTTTTCCATTG GTTTTGA f606.aa (SEQ ID NO:585) MKLQRSLFLIIFFLTFLCCNNKERKEGVSFKISLGAEPSSLDPQLAEDNVASKMIDTMFRGIV TGDPNTGGNKPGLAKGWDISSDGTVYTFNLREKITWSDGVAITAEGIRKSYLRILNKETGSKYVEM VKSVIKNGQKYFDGQVTDSELGIRAIDEKTLEITLESPKPYFIDMLVHQSFIPVPVHVTEKYGQNWTS PENMVTSGPFKLKERIPNEKYVFEKNNKYYDSNEVELEEITFYTTNDSSTAYKMYENEELDAIFGSIP PDLIKNLKLRSDYYSSAVNAIYFYAFNTHIKPLDNVKIRKALTLAIDRETLTYKVLDNGTTPTRRATP NFSSYSYAKSLELFNPEIAKTLLAEAGYPNGNGFPILKLKYNTNEANKKICEFIQNQWKKNLNIDVEL ENEEWTTYLNTKANGNYEIARAGWIGDYADPLTFLSIFTQGYTQFSSHNYSNPEYNELIKKSDLELD PIKRQDILRQAEEIIIEKDFPIAPIYIYGNSYLFRNDKWTGWNTNILERFDLSQLKLKNK t606.aa (SEQ ID NO:586) CCNNKERKEGVSFKISLGAEPSSLDPQLAEDNVASKMIDTMFRGIVTGDPNTGGNKPGLAK GWDISSDGTVYTFNLREKITWSDGVAITAEGIRKSYLRILNKETGSKYVEMVKSVIKNGQKYFDGQ VTDSELGIRAIDEKTLEITLESPKPYFIDMLVHQSFIPVPVHVTEKYGQNWTSPENMVTSGPFKLKERI PNEKYVFEKNNKYYDSNEVELEEITFYTTNDSSTAYKMYENEELDAIFGSIPPDLIKNLKLRSDYYSS AVNAIYFYAFNTHIKPLDNVKIRKALTLAIDRETLTYKVLDNGTTPTRRATPNFSSYSYAKSLELFNP EIAKTLLAEAGYPNGNGFPILKLKYNTNEANKKICEFIQNQWKKNLNIDVELENEEWTTYLNTKAN GNYEIARAGWIGDYADPLTFLSIFTQGYTQFSSHNYSNPEYNELIKKSDLELDPIKRQDILRQAEEIIIE KDFPIAPIYIYGNSYLFRNDKWTGWNTNILERFDLSQLKLKNK f606.nt (SEQ ID NO:587) ATGAAATTACAAAGGTCATTATTTTTAATAATATTTTTTCTAACTTTTCTTTGTTGTAAT AACAAGGAAAGAAAAGAAGGAGTATCATTTAAAATAAGCTTGGGAGCAGAGCCAAGCAGTCTT GACCCTCAATTAGCAGAGGATAATGTCGCATCAAAAATGATTGACACAATGTTTAGAGGGATTG TTACAGGAGATCCTAATACAGGGGGAAATAAACCGGGACTTGCAAAAGGGTGGGATATTTCTT CTGATGGAACAGTTTACACATTTAACCTAAGAGAAAAAATCACTTGGAGTGACGGAGTTGCAAT CACTGCAGAAGGAATTAGAAAATCTTATCTTAGAATTTTAAATAAAGAAACTGGCTCAAAGTAC GTTGAAATGGTTAAATCGGTAATTAAAAATGGTCAAAAATATTTTGATGGACAAGTGACTGACT CTGAACTTGGAATTAGAGCGATTGATGAAAAAACATTAGAAATAACACTGGAATCACCAAAAC CTTATTTTATTGATATGTTAGTACACCAATCATTTATTCCAGTACCAGTTCATGTTACCGAAAAG TATGGACAAAACTGGACAAGCCCCGAAAACATGGTGACAAGTGGTCCTTTTAAATTAAAAGAA AGAATTCCTAACGAAAAATATGTCTTTGAAAAAAAATAACAAATACTACGACTCAAATGAAGTA GAATTAGAAGAGATTACATTTTACACAACAAATGACAGCTCAACAGCGTATAAAATGTATGAA AATGAAGAGCTAGATGCAATTTTTGGTTCCATACCCCCAGATCTAATCAAAAATCTAAAATTAA GAAGCGACTATTACTCATCAGCTGTTAATGCCATATACTTTTACGCGTTCAATACACACATCAA ACCACTTGACAACGTTAAAATTAGAAAAGCCTTAACTCTTGCTATTGACAGAGAAACGCTTACA TATAAAGTTCTTGACAACGGGACTACCCCTACAAGAAGAGCAACTCCCAACTTTAGTTCATATT CTTATGCAAAAAGTTTAGAATTATTTAATCCTGAAATTGCAAAAACCCTTCTAGCTGAAGCTGG ATATCCTAATGGCAATGGATTTCCAATTTTAAAATTAAAATACAATACAAACGAAGCAAATAAA AAAATTTGTGAATTTATTCAAAACCAATGGAAAAAAAAATTTAAATATTGATGTGGAACTTGAAA ACGAAGAATGGACAACATACTTAAACACTAAGGCAAATGGAAATTATGAAATAGCAAGAGCAG GATGGATAGGCGATTATGCTGATCCTTTGACATTTTTAAGCATATTCACACAAGGATACACACA ATTCTCATCTCATAATTACTCAAACCCAGAATACAACGAACTTATAAAGAAATCCGACCTTGAG CTTGATCCAATAAAAAGACAAGACATTTTAAGACAAGCAGAAGAGATAATTATTGAAAAAGAT TTTCCAATAGCACCAATATACATATATGGGAACAGTTACCTTTTCAGAAATGACAAATGGACAG GGTGGAACACCAATATTTTAGAAAGATTTGATTTATCTCAGCTAAAATTAAAAAATAAATAA t606.nt (SEQ ID NO:588) TGTTGTAATAACAAGGAAAGAAAAGAAGGAGTATCATTTAAAATAAGCTTGGGAGCAG AGCCAAGCAGTCTTGACCCTCAATTAGCAGAGGATAATGTCGCATCAAAAATGATTGACACAAT GTTTAGAGGGATTGTTACAGGAGATCCTAATACAGGGGGAAATAAACCGGGACTTGCAAAAGG GTGGGATATTTCTTCTGATGGAACAGTTTACACATTTAACCTAAGAGAAAAAATCACTTGGAGT GACGGAGTTGCAATCACTGCAGAAGGAATTAGAAAATCTTATCTTAGAATTTTAAATAAAGAA ACTGGCTCAAAGTACGTTGAAATGGTTAAATCGGTAATTAAAAATGGTCAAAAATATTTTGATG GACAAGTGACTGACTCTGAACTTGGAATTAGAGCGATTGATGAAAAAACATTAGAAATAACAC TGGAATCACCAAAACCTTATTTTATTGATATGTTAGTACACCAATCATTTATTCCAGTACCAGTT CATGTTACCGAAAAGTATGGACAAAACTGGACAAGCCCCGAAAACATGGTGACAAGTGGTCCT TTTAAATTAAAAGAAAGAATTCCTAACGAAAAATATGTCTTTGAAAAAAATAACAAATACTACG ACTCAAATGAAGTAGAATTAGAAGAGATTACATTTTACACAACAAATGACAGCTCAACAGCGT ATAAAATGTATGAAAATGAAGAGCTAGATGCAATTTTTGGTTCCATACCCCCAGATCTAATCAA AAATCTAAAATTAAGAAGCGACTATTACTCATCAGCTGTTAATGCCATATACTTTTACGCGTTC AATACACACATCAAACCACTTGACAACGTTAAAATTAGAAAAGCCTTAACTCTTGCTATTGACA GAGAAACGCTTACATATAAAGTTCTTGACAACGGGACTACCCCTACAAGAAGAGCAACTCCCA ACTTTAGTTCATATTCTTATGCAAAAAGTTTAGAATTATTTAATCCTGAAATTGCAAAAACCCTT CTAGCTGAAGCTGGATATCCTAATGGCAATCGATTTCCAATTTTAAAATTAAAATACAATACAA ACGAAGCAAATAAAAAAATTTGTGAATTTATTCAAAACCAATGGAAAAAAAATTTAAATATTG ATGTGGAACTTGAAAACGAAGAATGGACAACATACTTAAACACTAAGGCAAATGGAAATTATG AAATAGCAAGAGCAGGATGGATAGGCGATTATGCTGATCCTTTGACATTTTTAAGCATATTCAC ACAAGGATACACACAATTCTCATCTCATAATTACTCAAACCCAGAATACAACGAACTTATAAAG AAATCCGACCTTGAGCTTGATCCAATAAAAAGACAAGACATTTTAAGACAAGCAGAAGAGATA ATTATTGAAAAAGATTTTCCAATAGCACCAATATACATATATGGGAACAGTTACCTTTTCAGAA ATGACAAATGGACAGGGTGGAACACCAATATTTTAGAAAGATTTGATTTATCTCAGCTAAAATT AAAAAATAAATAA f679.aa (SEQ ID NO:589) MFNRSSCVLQNFLFLFLFLSLVSCFAKKEISGNNFIKAHSKEFDLNNLNWLWNFDYTKKNF DKHFNIDPSSYIYVAYLFKKIGFEEKFVEYMKKAIANGDSIASQFAGIKLIEYFNSAKEYFASELIGEK LYKKYENNKFIILGYFKSLYWQKKNDKALSLLNKLDKMKFSDYQENENILLKAVLYLNLSNVSESK IYFNELFENLPANYLHVRAYDYFIIENKSRYFGANFLNLVRFKYEVANGNFNGAINILNKNGLNDYY DNNIVLSDVYKAFISSGKVSNALTFFSKIKSKYKNYYLGILNLREKNNLGLLLLKEYLEGLDLNNEIN RLDLLNTAFSNLIFTKSARDYFAESLPKFYTEGDKKNSTFIKILEEYILESIQLEDYGNLYKLYSNAQK VISNSVLSKLAFINARLIYHKLIKPNVSGEYKSLLHSAVNYDKWSYSSFMSRYLLDQNIDEFFTGGSDI KYEQSDYEIFLEGFLKFNLCNYVRGFISEDFRNGYKFSLDFYRKVYDELLKSENYYDATLVINYLVN QDESALMENDYKRLYPYLYGSLIEYWAKRRGLEASVVFSLIKAESSFEKNAVSKPGAVGLMQYMPS TANDISKELKYFNYDLKIPKDNIIIGTYYLKKRISTTGSLYKALASYNGGIGNVRKWEKSYGHLSKEL FIEAIPFSQTRNYIKKILVYSVFYDALYEKKGIDSVIVKIMGEFPKN t679.aa (SEQ ID NO:590) CFAKKEISGNNFIKAHSKEFDLNNLNWLWNFDYTKKNFDKHFNIDPSSYIYVAYLFKKIGFE EKFVEYMKKAIANGDSIASQFAGIKLIEYFNSAKEYFASELIGEKLYKKYENNKFIILGYFKSLYWQK KNDKALSLLNKLDKMKFSDYQENENILLKAVLYLNLSNVSESKIYFNELFENLPANYLHVRAYDYFI IENKSRYFGANFLNLVRFKYEVANGNFNGAINILNKNGLNDYYDNNIVLSDVYKAFISSGKVSNALT FFSKIKSKYYNYYLGILNLREKNNLGLLLLKEYLEGLDLNNEINRLDLLNTAFSNLIFTKSARDYFAE SLPKFYTEGDKKNSTFIKILEEYILESIQLEDYGNLYKLYSNAQKVISNSVLSKLAFINARLIYHKLIKP NVSGEYKSLLHSAVNYDKWSYSSFMSRYLLDQNIDEFFTGGSDIKYEQSDYEIFLEGFLKFNLCNYV RGFISEDFRNGYKFSLDFYRKVYDELLKSENYYDATLVINYLVNQDESALMENDYKRLYPYLYGSLI EYWAKRRGLEASVVFSLIKAESSFEKNAVSKPGAVGLMQVMPSTANDISKELKYFNYDLKIPKDNIII GTYYLKKRISTTGSLYKALASYNGGIGNVRKWEKSYGHLSKELFIEAIPFSQTRNYIKKILVYSVFYD ALYEKKGIDSVIVKIMGEFPKN f679.nt (SEQ ID NO:591) ATGTTTAATAGAAGTTCTTGTGTATTACAAAATTTTCTTTTTCTTTTTTTATTTTTAAGTTTAGTT TCTTGCTTTGCAAAAAAAGAAATCTCAGGCAATAATTTTATTAAGGCGCATTCAAAAGAGTTTG ATTTAAATAATTTAAATTGGTTATGGAATTTTGATTATACAAAAAAAAATTTTGATAAGCATTTT AACATAGATCCAAGTTCTTACATATATGTTGCTTATTTATTTAAAAAAATAGGATTTGAAGAGA AATTTGTAGAGTATATGAAAAAGGCCATAGCTAATGGAGATAGCATTGCATCCCAGTTTGCTGG GATTAAGCTTATTGAATATTTTAACTCAGCAAAAGAGTATTTTGCATCTGAATTGATTGGAGAG AAGCTTTATAAAAATACGAAAATAATAAATTTATTATACTGGGGTACTTTAAAAGTCTTFATT GGCAAAAGAAAAACGATAAGGCACTTAGTCTTTTAAATAAGCTTGATAAGATGAAATTTTCTGA TTATCAGGAAAATGAAAATATTTTATTAAAAGCAGTTCTTTACCTTAATCTTFCTAATGTAAGTG AGTCAAAAATTTATTTTAATGAGCTTTTTGAGAACTFACCTGCAAATTATTTACATGTAAGAGCT TATGATTATTTTATTATTGAAAATAAGTCTAGGTATTTTGGTGCAAATTTTTTAAATCTTGTTAG ATTTAAGTATGAAGTGGCAAATGGCAATTTTAATGGTGCAATAAATATATTAAATAAAAATGGT TTAAATGATTATTATGACAATAACATTGTATTAAGTGATGTTTATAAGGCTTTTATTAGTTCTGG CAAAGTTTCAAATGCTTTAACATTTTTTAGTAAAATAAAGAGCAAATATAAAAATTATTATTTA GGTATTCTAAACCTTAGAGAGAAAAATAATTTAGGACTTCTTCTTTTAAAAGAATATCTTGAAG GTTTAGATCTTAACAATGAGATTAACAGGCTTGATTTGCTTAATACTGCTTTTAGCAATTTAATT TTTACTAAGAGCGCAAGGGATTATTTTGCCGAAAGTTTACCCAAGTTTTATACCGAGGGCGATA AAAAAAATTCTACTTTTATTAAGATTTTAGAAGAGTATATTTTGGAATCAATTCAGCTTGAAGA CTATGGCAATCTTTATAAGCTTTATTCTAATGCTCAAAAAGTTATTTCTAATTCTGTTTTGTCTA AGCTTGCTTTTATTAATGCAAGGCTTATATATCATAAATTAATTAAACCTAACGTAAGCGGAGA ATACAAGAGTCTTTTGCATTCTGCTGTTAATTATGATAAATGGTCTTATTCTTCATTTATGAGTA GGTACTTATTAGATCAAAATATTGATGAATTTTTTACAGGTGGGTCTGATATTAAGTATGAGCA ATCCGATTATGAGATTTTTTTGGAAGGGTTTTTAAAATTCAATCTTTGTAATTATGTTAGAGGGT TTATTTCTGAGGATTTTAGGAATGGATATAAATTTTCACTTGATTTTTATCGAAAAGTATACGAT GAACTTTTAAAGAGTGAAAATTATTACGATGCAACTCTTGTGATTAATTATCTTGTAAATCAAG ATGAATCTGCTTTAATGGAGAATGACTATAAAAGACTTTATCCTTATTTGTATGGATCTTTGATA GAATATTGGGCTAAAAGGAGAGGGCTTGAAGCTAGTGTTGTATTTTCTTTAATAAAAGCAGAG AGTAGCTTTGAAAAAAATGCTGTCTCAAAACCGGGTGCTGTTGGCCTTATGCAGGTTATGCCAT CAACAGCAAATGATATTTCTAAAGAACTTAAGTATTTTAACTATGATTTAAAGATTCCAAAAGA TAATATAATAATTGGAACATATTATTTAAAAAAAAGAATATCTACAACTGGCAGTCTTTATAAG GCTCTTGCGTCTTATAATGGGGGTATTGGTAATGTTAGAAAGTGGGAGAAAAGTTATGGACATT TGTCAAAAGAGCTTTTTATTGAGGCAATTCCCTTTAGTCAAACTAGGAATTATATTAAAAAAAT ATTAGTTTATTCGGTATTTTATGATGCTTTGTATGAAAAGAAGGGAATAGATTCAGTAATAGTT AAAATTATGGGCGAATTCCCCAAAAATTAA t679.nt (SEQ ID NO:592) TGCTTTGCAAAAAAAGAAATCTCAGGCAATAATTTTATTAAGGCGCATTCAAAAGAGTTTGATT TAAATAATTTAAATTGGTTATGGAATTTTGATTATACAAAAAAAAATTTTGATAAGCATTTTAA CATAGATCCAAGTTCTTACATATATGTTGCTTATTTATTTAAAAAAATAGGATTTGAAGAGAAA TTTGTAGAGTATATGAAAAAGGCCATAGCTAATGGAGATAGCATTGCATCCCAGTTTGCTGGGA TTAAGCTTATTGAATATTTTAACTCAGCAAAAGAGTATTTTGCATCTGAATTGATTGGAGAGAA GCTTTATAAAAAATACGAAAATAATAAATTTATTATACTGGGGTACTTTAAAAGTCTTTATTGG CAAAAGAAAAACGATAAGGCACTTAGTCTTTTAAATAAGCTTGATAAGATGAAATTTTCTGATT ATCAGGAAAATGAAAATATTTTATTAAAAGCAGTTCTTTACCTTAATCTTTCTAATGTAAGTGA GTCAAAAATTTATTTTAATGAGCTTTTTGAGAACTTACCTGCAAATTATTTACATGTAAGAGCTT ATGATTATTTTATTATTGAAAATAAGTCTAGGTATTTTGGTGCAAATTTTTTAAATCTTGTTAGA TTTAAGTATGAAGTGGCAAATGGCAATTTTAATGGTGCAATAAATATATTAAATAAAAATGGTT TAAATGATTATTATGACAATAACATTGTATTAAGTGATGTTTATAAGGCTTTTATTAGTTCTGGC AAAGTTTCAAATGCTTTAACATTTTTTAGTAAAATAAAGAGCAAATATAAAAATTATTATTTAG GTATTCTAAACCTTAGAGAGAAAAATAATTTAGGACTTCTTCTTTTAAAAGAATATCTTGAAGG TTTAGATCTTAACAATGAGATTAACAGGCTTGATTTGCTTAATACTGCTTTTAGCAATTTAATTT TTACTAAGAGCGCAAGGGATTATTTTGCCGAAAGTTTACCCAAGTTTTATACCGAGGGCGATAA AAAAAATTCTACTTTTATTAAGATTTTAGAAGAGTATATTTTGGAATCAATTCAGCTTGAAGAC TATGGCAATCTTTATAAGCTTTATTCTAATGCTCAAAAAGTTATTTCTAATTCTGTTTTGTCTAA GCTTGCTTTTATTAATGCAAGGCTTATATATCATAAATTAATTAAACCTAACGTAAGCGGAGAA TACAAGAGTCTTTTGCATTCTGCTGTTAATTATGATAAATGGTCTTATTCTTCATTTATGAGTAG GTACTTATTAGATCAAAATATTGATGAATTTTTTACAGGTGGGTCTGATATTAAGTATGAGCAA TCCGATTATGAGATTTTTTTGGAAGGGTTTTTAAAATTCAATCTTTGTAATTATGTTAGAGGGTT TATTTCTGAGGATTTTAGGAATGGATATAAATTTTCACTTGATTTTTATCGAAAAGTATACGATG AACTTTTAAAGAGTGAAAATTATTACGATGCAACTCTTGTGATTAATTATCTTGTAAATCAAGA TGAATCTGCTTTAATGGAGAATGACTATAAAAGACTTTATCCTTATTTGTATGGATCTTTGATAG AATATTGGGCTAAAAGGAGAGGGCTTGAAGCTAGTGTTGTATTTTCTTTAATAAAAGCAGAGA GTAGCTTTGAAAAAAATGCTGTCTCAAAACCGGGTGCTGTTGGCCTTATGCAGGTTATGCCATC AACAGCAAATGATATTTCTAAAGAACTTAAGTATTTTAACTATGATTTAAAGATTCCAAAAGAT AATATAATAATTGGAACATATTATTTAAAAAAAAGAATATCTACAACTGGCAGTCTTTATAAGG CTCTTGCGTCTTATAATGGGGGTATTGGTAATGTTAGAAAGTGGGAGAAAAGTTATGGACATTT GTCAAAAGAGCTTTTTATTGAGGCAATTCCCTTTAGTCAAACTAGGAATTATATTAAAAAAATA TTAGTTTATTCGGTATTTTATGATGCTTTGTATGAAAAGAAGGGAATAGATTCAGTAATAGTTA AAATTATGGGCGAATTCCCCAAAAATTAA f11-12.nt (SEQ ID NO:593) TAAAAGGAGAATATTTTTATGAGAAAAAGTTTGTTTTTATATGCATTATTAATGGGAGGATTGA TGTCTTGTAATCTAGATTCCAAATTATCTAGTAACAAAGAACAAAAAAATAACAATAATGTAAA AGAAGTTTCGGATAGTGTTCAAGAAGATGGTCTTAATGATTTATATAATAATCAAGAAAAGCAA AAAAGCTTTACTAAAAATTTTGGAGAACGGAAATATGAGGATTTAATTAATCCTATAGAGCCTA TAATACCTTCAGAATCACCAAAGAATAAGGCTAATATACCAAATATTTCAATTGCGCATACTGA AAAAAAAGAGACAAAAAAGGAGAATTTAATCCCTTCTACTAATGAAGAAAAGGAAGCTGATGC AGCAATTAAATATTTAGAAGAAAATATTCTTAAAAACTCTAAATTTTCTGAATTAATTAGAGAA GTACGTGTAATTAAAGATGAATATGCTTTAATAAAAGCTGATTTGTATGATGTAATTGGAAAGA TTAACAATAAAAAAACATCATTAATGGAGAATCCTAAGAACAATAGAGATAAGATAAATAAAT TAACACAATTGTTGCAAAATAATTTAAAGATAGATAGTGAACTTGAGCAGCTTATAAATATGAT TGATATGGCAGAAAATGAAATAAGCTCTGCGGCTTTCTTTTTTGACAACGCTCAGAAAAGGTTA AAAGAAAGCATTATTAAAAGATTAGAGAGTAAAAATAATAGATCTTATGCATTAAAATTGTCTA GACAGGCTTTAAGTGACGCAAGAAGTGCTTTAAGTAATTTAGAATCTTTTGCCTCTAAAAGAAT TGAACCAATGGTGAGAAAGGAAGAAATAAAAGAGCTTATTAAACATGCAAAAACTGTTTTAGA AAGTGTCAATAAAAAATAA t11-12.nt (SEQ ID NO:594) TTGTAATCTAGATTCCAAATTATCTAGTAACAAAGAACAAAAAAATAACAATAATGTAAAAGA AGTTTCGGATAGTGTTCAAGAAGATGGTCTTAATGATTTATATAATAATCAAGAAAAGCAAAAA AGCTTTACTAAAAATTTTGGAGAACGGAAATATGAGGATTTAATTAATCCTATAGAGCCTATAA TACCTTCAGAATCACCAAAGAATAAGGCTAATATACCAAATATTTCAATTGCGCATACTGAAAA AAAAGAGACAAAAAAGGAGAATTTAATCCCTTCTACTAATGAAGAAAAGGAAGCTGATGCAGC AATTAAATATTTAGAAGAAAATATTCTTAAAAACTCTAAATTTTCTGAATTAATTAGAGAAGTA CGTGTAATTAAAGATGAATATGCTTTAATAAAAGCTGATTTGTATGATGTAATTGGAAAGATTA ACAATAAAAAAACATCATTAATGGAGAATCCTAAGAACAATAGAGATAAGATAAATAAATTAA CACAATTGTTGCAAAATAATTTAAAGATAGATAGTGAACTTGAGCAGCTTATAAATATGATTGA TATGGCAGAAAATGAAATAAGCTCTGCGGCTTTCTTTTTTGACAACGCTCAGAAAAGGTTAAAA GAAAGCATTATTAAAAGATTAGAGAGTAAAAATAATAGATCTTATGCATTAAAATTGTCTAGAC AGGCTTTAAGTGACGCAAGAAGTGCTTTAAGTAATTTAGAATCTTTTGCCTCTAAAAGAATTGA ACCAATGGTGAGAAAGGAAGAAATAAAAGAGCTTATTAAACATGCAAAAACTGTTTTAGAAAG TCTCAATAAAAAA f11-12.aa (SEQ ID NO:595) KENIFMRKSLFLYALLMGGLMSCNLDSKLSSNKEQKNNNNVKEVSDSVQEDGLNDLYNNQEKQKS FTKNFGERKYEDLINPIEPIIPSESPKNKANIPNISIAHTEKKETKKENLIPSTNEEKEADAAIKYLEENI LKNSKFSELIREVRVIKDEYALIKADLYDVIGKINNKKTSLMENPKNNRDKINKLTQLLQNNLKIDSE LEQLINMIDMAENEISSAAFFFDNAQKRLKESIIKRLESKNNRSYALKLSRQALSDARSALSNLESFAS KRIEPMVRKEEIKELIKHAKTVLESLNKK t11-12.aa (SEQ ID NO:596) CNLDSKLSSNKEQKNNNNVKEVSDSVQEDGLNDLYNNQEKQKSFTKNFGERKYEDLINPI EPIIPSESPKNKANIPNISIAHTEKKETKKENLIPSTNEEKEADAAIKYLEENILKNSKFSELIREVRVIK DEYALIKADLYDVIGKINNKKTSLMENPKNNRDKINKLTQLLQNNLKIDSELEQLINMIDMAENEISS AAFFFDNAQKRLKESIIKRLESKNNRSYALKLSRQALSDARSALSNLESFASKRIEPMVRKEEIKELIK HAKTVLESLNKK f11-4.nt (SEQ ID NO:597) TAAAGGAGTTTACAAATGAGTAAACTAATATTGGCAATATCTATACTGCTAATAATTTCATGTA AATGGTATGTAGACAATACCATTGATGAAGCAACTGTAGAAAGTAAATCAGCACTAACATCTAT TGATCAAGTATTAGATGAGATAAGTGAAGCCACAGGCCTAAGTTCGGAAAAAATCACAAAATT AACTCCGGAAGAGCTAGAAAATTTAGCAAAGGAAGCTCAAGATGACTCTGAAAAATCCAAAAA AGAAATTGAAGATCAAAAAAATACCAAGGAAAGTAAAAACATAGAAGTAAAGGATACTCCTCG CTTAATCAAATTGATAAAGAATTCATCAGAAAAAATTGATTCGGTTTTTCAAACACTAATTAAT ATAGGTTATAATGCTACCTATGCAGCCAAAAGTAATTTGAAGAATGGACTAAAGATGGTGAAA TTACTGGATGAGTTGCTAAAAATATCGGTAAGTAGCAATGGTGATAAAAGTACCCAAAAATAC AATGAACTTAAAACCGTTGTAAATAAGTTTAATGCTGAAAATTCGGTAAGCGTTTCTTTTAAAG AACATTCAAACAGTAAAATTGAAACTAAAAAATGTATTCAAACTCTTATGAAAAATGTAGAAAC ATACTTTGAAGGTGTATGCAGCGAACTTAAAAACAAAAATGATGGTGAGTACGAAAAAACATT GACAACTTTAAGCTAA t11-4.nt (SEQ ID NO:598) ATGTAAATGGTATGTAGACAATACCATTGATGAAGCAACTGTAGAAAGTAAATCAGCACTAAC ATCTATTGATCAAGTATTAGATGAGATAAGTGAAGCCACAGGCCTAAGTTCGGAAAAAATCAC AAAATTAACTCCGGAAGAGCTAGAAAATTTAGCAAAGGAAGCTCAAGATGACTCTGAAAAATC CAAAAAAGAAATTGAAGATCAAAAAAATACCAAGGAAAGTAAAAACATAGAAGTAAAGGATA CTCCTCGCTTAATCAAATTGATAAAGAATTCATCAGAAAAAATTGATTCGGTTTTTCAAACACT AATTAATATAGGTTATAATGCTACCTATGCAGCCAAAAGTAATTTGAAGAATGGACTAAAGATG GTGAAATTACTGGATGAGTTGCTAAAAATATCGGTAAGTAGCAATGGTGATAAAAGTACCCAA AAATACAATGAACTTAAAACCGTTGTAAATAAGTTTAATGCTGAAAATTCGGTAAGCGTTTCTT TTAAAGAACATTCAAACAGTAAAATTGAAACTAAAAAATGTATTCAAACTCTTATGAAAAATGT AGAAACATACTTTGAAGGTGTATGCAGCGAACTTAAAAACAAAAATGATGGTGAGTACGAAAA A f11-4.aa (SEQ ID NO:599) RSLQMSKLILAISILLIISCKWYVDNTIDEATVESKSALTSIDQVLDEISEATGLSSEKITKLTPEELENL AKEAQDDSEKSKKEIEDQKNTKESKNIEVKDTPRLIKLIKNSSEKIDSVFQTLINIGYNATYAAKSNL KNGLKMVKLLDELLKISVSSNGDKSTQKYNELKTVVNKFNAENSVSVSFKEHSNSKIETKKCIQTL MKNVETYFEGVCSELKNKNDGEYEKTLTTLS t11-4.aa (SEQ ID NO:600) CKWYVDNTIDEATVESKSALTSIDQVLDEISEATGLSSEKITKLTPEELENLAKEAQDDSEKSKKEIE DQKNTKESKNIEVKDTPRLIKLIKNSSEKIDSVFQTLINIGYNATYAAKSNLKNGLKMVKLLDELLKI SVSSNGDKSTQKYNELKTVVNKFNAENSVSVSFKEHSNSKIETKKCIQTLMKNVETYFEGVCSELK NKNDGEYEK f112-1.nt (SEQ ID NO:601) TGAATCTCTAAAGATTTTAGCAGGGGAGAAAATATGAAAAAAAGTTTTTTATCAATATACATGT TAATTTCAATAAGTTTATTATCATGTGATGTTAGTAGATTAAATCAGAGAAATATTAATGAGCT TAAAATTTTTGTTGAAAAGGCCAAGTATTATTCTATAAAATTAGACGCTATTTATAACGAATGT ACAGGAGCATATAATGATATTATGACTTATTCGGAAGGTACATTTTCTGATCAAAGTAAGGTTA ATCAAGCTATATCTATATTTAAAAAAGACAATAAAATTGTTAATAAGTTTAAGGAGCTTGAAAA GATTATAGAAGAATACAAACCTATGTTTTTAAGTAAATTAATTGATGATTTTGCGGGATCCGTT t112-1.nt (SEQ ID NO:602) ATGTGATGTTAGTAGATTAAATCAGAGAAATATTAATGAGCTTAAAATTTTTGTTGAAAAGGCC AAGTATTATTCTATAAAATTAGACGCTATTTATAACGAATGTACAGGAGCATATAATGATATTA TGACTTATTCGGAAGGTACATTTTCTGATCAAAGTAAGGTTAATCAAGCTATATCTATATTTAA AAAAGACAATAAAATTGTTAATAAGTTTAAGGAGCTTGAAAAGATTATAGAAGAATACAAACC TATGTTTTTAAGTAAATTAATTGATGATTTT f112-1.aa (SEQ ID NO:603) ISKDFSRGEN MKKSFLSIYM LISISLLSCD VSRLNQRNIN ELKIFVEKAK YYSIKLDAIY NECTGAYNDI MTYSEGTFSD QSKVNQAISI FKKDNKIVNK FKELEKIIEE YKPMFLSKLI DDFAGSV t112-1.aa (SEQ ID NO:604) CDVSRLNQRNINELKIFVEKAKYYSIKLDAIYNECTGAYNDIMTYSEGTFSDQSKVNQAISIFKKDNK IVNKFKELEKIIEEYKPMFLSKLIDDF f14-8.nt (SEQ ID NO:605) TAAATACAGAGCCATTCAAGGAGAGTATTTATGAAATACTATATATGTGTGTGTGTTTTTTTGC TTTTGAATGCTTGCAATTCAGATTTTAGCACTAATCAAGAAGATATTAAATATCCATCTGATAA AGAGAAATCAAAATCCAACATGGAAGCAAGCTCTAAAGAAGAAGATCCAAATAAAAAAATAAA AAATACACTGCTTAATGATTTAATAAATTTGATAGAAATAGCTAATGAGCATAAAGAAAAATAT GAAAAAAGAATGCAAGAAGAACCTTCAGATCAATACGGAATATTGGCTTTCCAGGAATTAGAC TTGTCCGTTGGAAAAATATCTGAAGACACCCCGCAATCTAAAAAATTTAGAAAAAACACCTATT CTCCCTTAAGCGCTATTGATGTCAATAAATTAAAAGATCTTTCAGAGATTATAAGAAATTCGGG CCAAATACAAGGTTTATTTAATATTTTCAACAGATTCGGAGGCATTTTTGACGACTCACTTAATC ACGTATATTCTAAAAAAGATATCCTAGGGGGACTAGAAATTTTGGATTTAGATAAACTAAAAAA TTCGTTTGAAAAATTACTATCTATAAAAGAAACTTTCTCAAAAATGCTAAATCAACTTTTATTAG ATTATAAAAATGATAAAGATCATATACGAACAGAGACAAATAAACTTAAATCTCATACAACTGC ACTTTTCGAACAACTTGATAAAAAAGAAGACGAAGCATATGAACCTAAAAATCAGATATTTTCA ATAAGTAACCTTTAA t14-8.nt (SEQ ID NO:606) TTGCAATTCAGATTTTAGCACTAATCAAGAAGATATTAAATATCCATCTGATAAAGAGAAATCA AAATCCAACATGGAAGCAAGCTCTAAAGAAGAAGATCCAAATAAAAAAATAAAAAATACACTG CTTAATGATTTAATAAATTTGATAGAAATAGCTAATGAGCATAAAGAAAAATATGAAAAGA ATGCAAGAAGAACCTTCAGATCAATACGGAATATTGGCTTTCCAGGAATTAGACTTGTCCGTTG GAAAAATATCTGAAGACACCCCGCAATCTAAAAAATTTAGAAAAAACACCTATTCTCCCTTAAG CGCTATTGATGTCAATAAATTAAAAGATCTTTCAGAGATTATAAGAAATTCGGGCCAAATACAA GGTTTATTTAATATTTTCAACAGATTCGGAGGCATTTTTGACGACTCACTTAATCACGTATATTC TAAAAAAGATATCCTAGGGGGACTAGAAATTTTGGATTTAGATAAACTAAAAAATTCGTTTGAA AAATTACTATCTATAAAAGAAACTTTCTCAAAAATGCTAAATCAACTTTTATTAGATTATAAAA ATGATAAAGATCATATACGAACAGAGACAAATAAACTTAAATCTCATACAACTGCACTTTTCGA ACAACTTGATAAAAAAGAAGACGAAGCATATGAACCTAAAAATCAG f14-8.aa (SEQ ID NO:607) IQSHSRRVFMKYYICVCVFLLLNACNSDFSTNQEDIKYPSDKEKSKSNMEASSKEEDPNKKIKNTLL NDLINLIEIANEHKEKYEKRMQEEPSDQYGILAFQELDLSVGKISEDTPQSKKFRKNTYSPLSAIDVN KLKDLSEIIRNSGQIQGLFNIFNRFGGIFDDSLNHVYSKKDILGGLEILDLDKLKNSFEKLLSIKETFSK MLNQLLLDYKNDKDHIRTETNKLKSHTTALFEQLDKKEDEAYEPKNQIFSISNL t14-8.aa (SEQ ID NO:608) CNSDFSTNQEDIKYPSDKEKSKSNMEASSKEEDPNKKIKNTLLNDLINLIEIANEHKEKYEKRMQEEP SDQYGILAFQELDLSVGKISEDTPQSKKFRKNTYSPLSAIDVNKLKDLSEIIRNSGQIQGLFNIFNRFGG IFDDSLNHVYSKKDILGGLEILDLDKLKNSFEKLLSIKETFSKMLNQLLLDYKNDKDHIRTETNKLKS HTTALFEQLDKKEDEAYEPKNQ f17-6.nt (SEQ ID NO:609) TAAAGGAGGGTATTTATGAAATACCACATAATTACAACTATATTTGTTTTTCTGTTTTTAGCTTG CAGGCCGGATTTTAATATCGATCAAAAAGACATTAAATACCCGCCTACTGAAAAATCAAGGCCC AAAACTGAAAGCTCTAAGCAAAAAGAATCAAAGCCTAAAACAGAAGAAGAGCTTAAGAAAAA ACAACAAGAAGAAGAGCTTAAGAAAAAACAACAAGAAGAAGAGCTTAAGAAAAAACAACAAG AAGAAGAGCTTAAGAAAAAACAACAAGAAGAAGAGAAGGAAGAACTAAGAAAACAACAACTA AAAAATACGCTATCTAATGATTTAAAAAAGCAAATAGAATCGGCCTACAATTTTAAAGAAAAAT ATGTAAAAAGTATGGAAAAAGAACCTGAAGACCATTACGGGATGACGTCTTTTAGGGGATTGA ATTGGGGGCCAGGGACTGAAGATATATCTGACAATACCGAAAGATCTATAAGATATAGAAGAC ACACTTATACTGTTTTAAGCCCCCTGGATCCTCATGAATTAAAGGAATTCGCAAATATTATTCA AGATATAAATAAACTAGCATCAGTAGCAAGTATATTTAATTCTTTTAGCGCTATTGGAGGAGCT CTTGACATAGTAAGTGATCACCTATATTTCAAAAAAGACAATCTAGACAAACTAGATATTGCAG ATTTAGAAATACTTAAAAATTCATTTGAACAAATATTATATATAAAAGGAAGTGTTGCAGGAAA AGCAAAAAAACTTTTATTAGATTATAAAAATCTAAAAACAGATATTAATAAGCTTAAATCTTAT TCAAATGAACTGGTTAATGGAATTAAGCAACAAGCTCTAGAAGCAGAAAATCTAGAAGAGCTT ATAGTGTCAAAATATAAACTTTAA t17-6.nt (SEQ ID NO:610) TTGCAGGCCGGATTTTAATATCGATCAAAAAGACATTAAATACCCGCCTACTGAAAAATCAAGG CCCAAAACTGAAAGCTCTAAGCAAAAAGAATCAAAGCCTAAAACAGAAGAAGAGCTTAAGAAA AAACAACAAGAAGAAGAGCTTAAGAAAAAACAACAAGAAGAAGAGCTTAAGAAAAAACAACA AGAAGAAGAGCTTAAGAAAAAACAACAAGAAGAAGAGAAGGAAGAACTAAGAAAACAACAAC TAAAAAATACGCTATCTAATGATTTAAAAAAGCAAATAGAATCGGCCTACAATTTTAAAGAAAA ATATGTAAAAAGTATGGAAAAAGAACCTGAAGACCATTACGGGATGACGTCTTTTAGGGGATT GAATTGGGGGCCAGGGACTGAAGATATATCTGACAATACCGAAAGATCTATAAGATATAGAAG ACACACTTATACTGTTTTAAGCCCCCTGGATCCTCATGAATTAAAGGAATTCGCAAATATTATTC AAGATATAAATAAACTAGCATCAGTAGCAAGTATATTTAATTCTTTTAGCGCTATTGGAGGAGC TCTTGACATAGTAAGTGATCACCTATATTTCAAAAAAGACAATCTAGACAAACTAGATATTGCA GATTTAGAAATACTTAAAAATTCATTTGAACAAATATTATATATAAAAGGAAGTGTTGCAGGAA AAGCAAAAAAACTTTTATTAGATTATAAAAATCTAAAAACAGATATTAATAAGCTTAAATCTTA TTCAAATGAACTGGTTAATGGAATTAAGCAACAAGCTCTAGAAGCAGAAAATCTAGAAGAGCT TATAGTGTCAAAATATAAACTT f17-6.aa (SEQ ID NO:611) RRVFMKYHIITTIFVFLFLACRPDFNIDQKDIKYPPTEKSRPKTESSKQKESKPKTEEELKKKQQEEEL KKKQQEEELKKKQQEEELKKKQQEEEKEELRKQQLKNTLSNDLKKQIESAYNFKEKYVKSMEKEP EDHYGMTSFRGLNWGPGTEDISDNTERSIRYRRHTYTVLSPLDPHELKEFANIIQDINKLASVASIFNS FSAIGGALDIVSDHLYFKKDNLDKLDIADLEILKNSFEQILYIKGSVAGKAKKLLLDYKNLKTDINKL KSYSNELVNGIKQQALEAENLEELIVSKYKL t17-6.aa (SEQ ID NO:612) CRPDFNIDQKDIKYPPTEKSRPKTESSKQKESKPKTEEELKKKQQEEELKKKQQEEELKKKQQEEEL KKKQQEEEKEELRKQQLKNTLSNDLKKQIESAYNFKEKYVKSMEKEPEDHYGMTSFRGLNWGPGT EDISDNTERSIRYRRHTYTVLSPLDPHELKEFANIIQDINKLASVASIFNSFSAIGGALDIVSDHLYFKK DNLDKLDIADLEILKNSFEQILYIKGSVAGKAKKLLLDYKNLKTDINKLKSYSNELVNGIKQQALEA ENLEELIVSKYKL f19-2.nt (SEQ ID NO:613) TAAAGAAAGATTAAATCATATTCAAGGAGAGTATTTATGAAACACTATATAATTGTGCATATAT TTGTTTTTCTATTTTTAAATGCTTGTTATCCAGTTGCATCTAATAAAATAGAATTAAAACCTAAA ACAGAAACAAGCTTAAATCAAGAAGAAGTCCCAAATCAAGAAGCAAACTACAAAGAAGAAAA AGAAGCAAAAGAAGAAGGCATTAATAAAAAAACAGAAAACACGCTGCTTAATGATTTAAGAAA TTTAATAGAAACAGCTAAAAAAGATAATGATAAATATACACAAAAGTTAAAAGAAGAATCCTC AAGCCAATACGGAATACTGGCTTTCAAAGATTTGTTCTGGCTAGATGGAACAAATGAACAATTG TCCGCAAATACCGAAAGATCTAAAGCCTATAGAAAACGAGCTTATAGCATCTTAAATACTATTA ATGACGCTTCCTTAAAGAATTTTTCAGAAATTGTAATGGCATCAGGACAAACACAGGGCATATT TAATACCCTTAACTCACTTGGGGGTAATTTTGAAAAGATAGTTAATTGTTTGTATCCCAAAAAA GACAATTTGGAAAAATTAGAGACTTCAGTTTTAAAAAAGCTTAAAGATTCTTTGGAAAATTTTT TAGAGATAAAAAAAATCGCCTCAGAAATGATGCACAAGCTCTTATTAGACTATCAAAATAATAC AAATCGTATACAAACAGATAAAAATGAACTTAAGTCTTATGCAGACACACTTTTCAATCAAATG ACAAAAAAACCCGAAGAAGCACTAAAGCTAAAAAATACCATATGCTCAATAGAGGACCTTTAA t19-2.nt (SEQ ID NO:614) TTGTTATCCAGTTGCATCTAATAAAATAGAATTAAAACCTAAAACAGAAACAAGCTTAAATCAA GAAGAAGTCCCAAATCAAGAAGCAAACTACAAAGAAGAAAAAGAAGCAAAAGAAGAAGGCAT TAATAAAAAAACAGAAAACACGCTGCTTAATGATTTAAGAAATTTAATAGAAACAGCTAAAAA AGATAATGATAAATATACACAAAAGTTAAAAGAAGAATCCTCAAGCCAATACGGAATACTGGC TTTCAAAGATTTGTTCTGGCTAGATGGAACAAATGAACAATTGTCCGCAAATACCGAAAGATCT AAAGCCTATAGAAAACGAGCTTATAGCATCTTAAATACTATTAATGACGCTTCCTTAAAGAATT TTTCAGAAATTGTAATGGCATCAGGACAAACACAGGGCATATTTAATACCCTTAACTCACTTGG GGGTAATTTTGAAAAGATAGTTAATTGTTTGTATCCCAAAAAAGACAATTTGGAAAAATTAGAG ACTTCAGTTTTAAAAAAGCTTAAAGATTCTTTGGAAAATTTTTTAGAGATAAAAAAAATCGCCT CAGAAATGATGCACAAGCTCTTATTAGACTATCAAAATAATACAAATCGTATACAAACAGATAA AAATGAACTTAAGTCTTATGCAGACACACTTTTCAATCAAATGACAAAAAAACCCGAAGAAGC ACTAAAG f19-2.aa (SEQ ID NO:615) RKIKSYSRRVFMKHYIIVHIFVFLFLNACYPVASNKIELKPKTETSLNQEEVPNQEANYKEEKEAKEE GINKKTENTLLNDLRNLIETAKKDNDKYTQKLKEESSSQYGILAFKDLFWLDGTNEQLSANTERSKA YRKRAYSILNTINDASLKNFSEIVMASGQTQGIFNTLNSLGGNFEKIVNCLYPKKDNLEKLETSVLKK LKDSLENFLEIKKIASEMMHKLLLDYQNNTNRIQTDKNELKSYADTLFNQMTKKPEEALKLKNTICS IEDL t19-2.aa (SEQ ID NO:616) CYPVASNKIELKPKTETSLNQEEVPNQEANYKEEKEAKEEGINKKTENTLLNDLRNLIETAKKDNDK YTQKLKEESSSQYGILAFKDLFWLDGTNEQLSANTERSKAYRKRAYSILNTINDASLKNFSEIVMAS GQTQGIFNTLNSLGGNFEKIVNCLYPKKDNLEKLETSVLKKLKDSLENFLEIKKIASEMMHKLLLDY QNNTNRIQTDKNELKSYADTLFNQMTKKPEEALK f19-4.nt (SEQ ID NO:617) TAATCTATACTAATTGAGGAGAATATTTTTATGAAAAACAACATAATTTTATGCATGTGTGTTTT TTTACTTTTAAATAGCTGCACCGCTAACCATGAAGCTGAAGCGAAAATAAAAAAACATGTTGAT AAAACAAAAAACGAATATATTAATGAAATAAAAAATTTAATAGCAACAACCAAAGAAATCATC GAAAAACGAAAATTGCTACAAGCTAAACCAGTAGATCAAAACCCCGTAGATGATACAAACAAT AAGAAAGTTTTCGAGATAGATAAAAGAGCTTTCGATTTTATAAATAGTTTTTTAACAGATGATG AATTTAATAAATTTGTAACAATATTTCATAAACCAACACTAAAATCACCCGGAAAAGTATTAAA TAGCATAGCAATTCTAGAGCTAAACATAGAGCAGGTAATTAATCACCTAGACTCAAAAAATGA GACCTTAAATAAAGCAAGCTCTTTAGATTTGGAAAAGATCAAAAATTCCCTTGAACAGCTGTTC TCTATAAGGAATTTTTTTTCAACAATCATAAAAAGGGTCTTATTAGATCATCAAAACAATGAAA ATTCTATAAAACCAGATGATTCTAAATCAGGAACCTATTTCGATACGATATACGATCAGTTTAA TGAAAAAAATAAAGAGGTTAGAAATCTGAAAAAAACCATATTATCACTGCCGAATTAA t19-4.nt (SEQ ID NO:618) CTGCACCGCTAACCATGAAGCTGAAGCGAAAATAAAAAAACATGTTGATAAAACAAAAAACGA ATATATTAATGAAATAAAAAATTTAATAGCAACAACCAAAGAAATCATCGAAAAACGAAAATT GCTACAAGCTAAACCAGTAGATCAAAACCCCGTAGATGATACAAACAATAAGAAAGTTTTCGA GATAGATAAAAGAGCTTTCGATTTTATAAATAGTTTTTTAACAGATGATGAATTTAATAAATTT GTAACAATATTTCATAAACCAACACTAAAATCACCCGGAAAAGTATTAAATAGCATAGCAATTC TAGAGCTAAACATAGAGCAGGTAATTAATCACCTAGACTCAAAAAATGAGACCTTAAATAAAG CAAGCTCTTTAGATTTGGAAAAGATCAAAAATTCCCTTGAACAGCTGTTCTCTATAAGGAATTT TTTTTCAACAATCATAAAAAGGGTCTTATTAGATCATCAAAACAATGAAAATTCTATAAAACCA GATGATTCTAAATCAGGAACCTATTTCGATACGATATACGATCAGTTTAATGAAAAAAATAAAG AGGTTAGAAATCTGAAAAAA f19-4.aa (SEQ ID NO:619) SILIEENIFMKNNIILCMCVFLLLNSCTANHEAEAKIKKHVDKTKNEYINEIKNLIATTKEIIEK RKLLQAKPVDQNPVDDTNNKKVFEIDKRAFDFINSFLTDDEFNKFVTIFHKPTLKSPGKVLNSIAILE LNIEQVINHLDSKNETLNKASSLDLEKIKNSLEQLFSIRNFFSTIIKRVLLDHQNNENSIKPDDSKSGTY FDTIYDQFNEKNKEVRNLKKTILSLPN t19-4.aa (SEQ ID NO:620) CTANHEAEAKIKKHVDKTKNEYINEIKNLIATTKEIIEKRKLLQAKPVDQNPVDDTNNKKVFEIDKR AFDFINSFLTDDEFNKFVTIFHKPTLKSPGKVLNSIAILELNIEQVINHLDSKNETLNKASSLDLEKIKN SLEQLFSIRNFFSTIIKRVLLDHQNNENSIKPDDSKSGTYFDTIYDQFNEKNKEVRNLKK f19-6.nt (SEQ ID NO:621) TAAAGGAGAGTATTAATGAAATGCCATATAATTGCAACTATATTTGTTTTTCTATTTTT AGCTTGCAGTACAGATTTTAATACTGATCAAAAAGGCATTAAATACCCGCCTACCGAAAAATCA AAGCCCAAAACTGAAGACTCTAAGCAAAAAGAATTAAAGCCTAAAACAGAAAAAGAACTAAAG AAAAAACAACAACTAAAAAATAAACTACTTAATGATTTAAAAAATTCAATAGAAACAGCTAAT AAGCATAAAGAAAAGTATAAAAAAAGAATGAAAGAAGAACCCGAAGATCAATACGGGGTACA GGCTTTCAAAGGATCGAATTGGGGGCCGGGGACTGAAGATGTATCTGCCAACACCGAAAGATC TATAAGATTTAGAAGACATACTTATACTATTTTAAGCACGCTGAGTCTTCATGAATTAAAGGAA TTCTCAAATATTGTTACAAATGAAAATAAACTGGTGCCAGTAGTAGATATGTTTAATTTCTTTA GCTCTATTGGGACAGCTCTTGATATAACAACCGATAGCTTATATCCCAAAAAGACAATCTGGAC AAACCAGATCTGTCGGATTTAG t19-6.nt (SEQ ID NO:622) TTGCAGTACAGATTTTAATACTGATCAAAAAGGCATTAAATACCCGCCTACCGAAAAAT CAAAGCCCAAAACTGAAGACTCTAAGCAAAAAGAATTAAAGCCTAAAACAGAAAAAGAACTAA AGAAAAAACAACAACTAAAAAATAAACTACTTAATGATTTAAAAAATTCAATAGAAACAGCTA ATAAGCATAAAGAAAAGTATAAAAAAAGAATGAAAGAAGAACCCGAAGATCAATACGGGGTA CAGGCTTTCAAAGGATCGAATTGGGGGCCGGGGACTGAAGATGTATCTGCCAACACCGAAAGA TCTATAAGATTTAGAAGACATACTTATACTATTTTAAGCACGCTGAGTCTTCATGAATTAAAGG AATTCTCAAATATTGTTACAAATGAAAATAAACTGGTGCCAGTAGTAGATATGTTTAATTTCTT TAGCTCTATTGGGACAGCTCTTGATATAACAACCGATAGCTTATATCCCAAAAAGACAATCTGG ACAAACCAGATCTGTCGG f19-6.aa (SEQ ID NO:623) RRVLMKCHIIATIFVFLFLACSTDFNTDQKGIKYPPTEKSKPKTEDSKQKELKPKTEKELKKKQQLK NKLLNDLKNSIETANKHKEKYKKRMKEEPEDQYGVQAFKGSNWGPGTEDVSANTERSIRFRRHTY TILSTLSLHELKEFSNIVTNENKLVPVVDMFNFFSSIGTALDITIDSLYPKKTIWTNQICRI t19-6.aa (SEQ ID NO:624) CSTDFNTDQKGIKYPPTEKSKPKTEDSKQKELKPKTEKELKKKQQLKNKLLNDLKNSIETANKHKE KYKKRMKEEPEDQYGVQAFKGSNWGPGTEDVSANTERSIRFRRHTYTILSTLSLHELKEFSNIVTNE NKLVPVVDMFNFFSSIGTALDITTDSLYPKKTIWTNQICR f21-4.nt (SEQ ID NO:625) TAGGAGACAATCTTTATGAATAAAAAAATAAAAATGTTTATTATTTGTGCTATTTTTATGCTGAT AAGTTCTTGTAAGAATGATGTAACTAGTAAAGATTTAGAAGGGGCGGTGAAAGATTTAGAAAG TTCAGAACAAAATGTAAAAAAAACAGAACAAGAGATAAAAAAACAAGTTGAAGGATTTTTAGA AATTTTAGAGACAAAAGATTTAAACACATTAGATACAAAAGAAATTGAAAAACAAATTCAAGA ATTAAAGAATAAGATAGAAAAATTAGACTCTAAAAAAACTTCTATTGAAACATATTCTGGGTAT GAAGAAAAAATAAACAAAATAAAAGAAAAATTAAACGGAAAAGGACTTGAAGATAAATTAAA TGAACTTTCAGAGAGCTTAAAAAAGAAAAAAGAGGAGAGAAAAAAAGCTTTACAAGAGGCTAA AAAGAAATTTGAAGAGTATAAAAACCAAGCTGAATCTGCAACTGGAGTAACGCATGGTTCTCA AGTCCAAAGACAAGGTGGTGTTGGATTACAAGCTTGGCAGTGTGCTAATAGTTTGGGGTTTAAA AATATGACTAGTGGTAATAATACTAGCGATATGACCAATGAAGTTATAACTAATTCGCTTAAAA AGATTGAAGAAGAACTTAAAAATATTGGAGAAACTGTAGAAGGTAAAAAAGAATAA t21-4.nt (SEQ ID NO:626) TTGTAAGAATGATGTAACTAGTAAAGATTTAGAAGGGGCGGTGAAAGATTTAGAAAGT TCAGAACAAAATGTAAAAAAAACAGAACAAGAGATAAAAAAACAAGTTGAAGGATTTTTAGAA ATTTTAGAGACAAAAGATTTAAACACATTAGATACAAAAGAAATTGAAAAACAAATTCAAGAA TTAAAGAATAAGATAGAAAAATTAGACTCTAAAAAAACTTCTATTGAAACATATTCTGGGTATG AAGAAAAAATAAACAAAATAAAAGAAAAATTAAACGGAAAAGGACTTGAAGATAAATTAAAT GAACTTTCAGAGAGCTTAAAAAAGAAAAAAGAGGAGAGAAAAAAAGCTTTACAAGAGGCTAA AAAGAAATTTGAAGAGTATAAAAACCAAGCTGAATCTGCAACTGGAGTAACGCATGGTTCTCA AGTCCAAAGACAAGGTGGTGTTGGATTACAAGCTTGGCAGTGTGCTAATAGTTTGGGGTTTAAA AATATGACTAGTGGTAATAATACTAGCGATATGACCAATGAAGTTATAACTAATTCGCTTAAAA AGATTGAAGAAGAACTTAAAAATATTGGAGAAACTGTAGAAGGTAAAAAAGAA f21-4.aa (SEQ ID NO:627) ETIFMNKKIKMFIICAIFMLISSCKNDVTSKDLEGAVKDLESSEQNVKKTEQEIKKQVEGFLEILETKD LNTLDTKEIEKQIQELKNKIEKLDSKKTSIETYSGYEEKINKIKEKLNGKGLEDKLNELSESLKKKKEE RKKALQEAKKKFEEYKNQAESATGVTHGSQVQRQGGVGLQAWQCANSLGFKNMTSGNNTSDMT NEVITNSLKKIEEELKNIGETVEGKKE t21-4.aa (SEQ ID NO:628) CKNDVTSKDLEGAVKDLESSEQNVKKTEQEIKKQVEGFLEILETKDLNTLDTKEIEKQIQELKNKIE KLDSKKTSIETYSGYEEKINKIKEKLNGKGLEDKLNELSESLKKKKEERKKALQEAKKKFEEYKNQA ESATGVTHGSQVQRQGGVGLQAWQCANSLGFKNMTSGNNTSDMTNEVITNSLKKIEEELKNIGET VEGKKE f14-1.nt (SEQ ID NO:629) TAAGCTGGTAACACTGTAAAGACAGCTGAGGGGGCTTCAAGTGGTACTGATGCAATTGGAGAA GTTGTGGATAATGATGCTAAGGTTGCTGATAAGGCGAGTGTGACGGGGATTGCTAAGGGGATA AAGGAGATTGTTGAAGCTGCTAGGGGGAGTGAAAAGCTGAAAGTTGCTGCTGCTAAAGAGGGC AATGAAAAGGCAGGGAAGTTGTTTGGGAAGGCTGGTGCTAATGCTCATGGGGACAGTGAGGCT GCTAGCAAGGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAGCAGATATTAAGTGCGATTGTTA AGGCTGCGGATGCGGCTGAGCAGGATGGAAAGAAGCCTGCAGATGCTACAAATCCGATTGCTG CTGCTATTGGGAATAAAGATGAGGATGCGGATTTTGGTGATGGGATGAAGAAGGATGATCAGA TTGCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAAGTTTGCTGTGAAGAATGATGA GAAAGGGAAGGCTGAGGGGGCTATTAAGGGAGCTGCTGCAATTGGAGAAGTTGTGGATAATGC TGGTGCTGCGAAGGCTGCTGATAAGGATAGTGTGAAGGGGATTGCTAAGGGGATAAAGGAGAT TGTTGAAGCTGCTGGGGGGAGTGAAAAGCTGAAAGCTGCTGCTGCTGAAGGGGAGAATAATAA AAAGGCAGGGAAGTTGTTTGGGAAAGTTGATGGTGCTGCTGGGGACAGTGAGGCTGCTAGCAA GGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAGCAGATATTAAGTGCGATTGTTAAGGCTGCT GGTGAGGCTGAGCAGGATGGAGAGAAGCCTGAGGATGCTAAAAATCCGATTGCTGCTGCTATT GGGAAGGGTAATGGGGATGGTGCGGAGTTTGATCAGGATGAGATGAAGAAGGATGATCAGATT GCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAAGTTTGCTGTGAAGGGTAATAAT GAGAAAGAGAAGGCTGAGGGGGCTATTAAAGAAGTTAGCGAGTTGTTGGATAAGCTGGTAACA GCTGTAAAGACAGCTGAGGGGGCTTCAAGTGGTACTGATGCAATTGGAGAAGTTGTGGATAAT GNTGCNAAGGNTGCTGATAAGGCGAGTGTGACGGGGATTGCTAAGGGGATAAAGGAGATTGTT GAAGCTGCTNGGGGGAGTGAAAAGCTGAAAGTTGCTGCTGCTANAGNGGNNAATAATAAAGA GGCAGGGAAGTTGTTTGGGAAGGCTGGTGCTGATGCTAATGGGGACAGTGAGGCTGCTAGCAA GGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAGCAGATATTAAGTGCGATTGTTAAGGCTGCG GCTGCTGGTGCGGCTGATCAGGATGGAGAGAAGCCTGGGGATGCTAAAAATCCGATTGCTGCT GCTATTGGGAAGGGTAATGCGGATGATGGTGCGGATTTTGGTGATGGGATGAAGAAGGATGAT CAGATTGCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAAGTTTGCTGTGAAGAAG GATGAGAAAGGGAAGGCTGAGGGGGCTATTAAGGGAGCTAGCGAGTTGTTGGATAAGCTGGTA AAAGCTGTAAAGACAGCTGAGGGGGCTTCAAGTGGTACTGCTGCAATTGGAGAAGTTGTGGAT AATGCTGCGAAGGCTGCTGATAAGGATAGTGTGACGGGGATTGCTAAGGGGATAAAGGAGATT GTTGAAGCTGCAGGGGGGAGTGAAAAGCTGAAAGTTGCTGCTGCTAAAGGGGAGAATAATAAA GGGGCAGGGAAGTTGTTTGGGAAGGCTGGTGCTAATGCTCATGGGGACAGTGAGGCTGCTAGC AAGGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAACAGATATTAAGTGCGATTGTTAAGGCTG CTGGTGAGGCTGCTGGTGATCAGGAGGGAAAGAAGCCTGAGGAGGCTAAAAATCCGATTGCTG CTGCTATTGGGGATAAAGATGGGGATGCGGAGTTTAATCAGGATGGGATGAAGAAGGATGATC AGATTGCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAAGTTTGCTGTGAAGGATG GTGGTGAGAAAGAGAAGGCTGAGGGGGCTATTAAAGGAGTTAGCGAGTTGTTGGATAAGCTGG TAAAAGCTGTAAAGACAGCTGAGGGGGCTTCAAGTGGTACTGCTGCAATTGGAGAAGTTGTGG CTGATGCTGCTAAGGTTGCTGATAAGGCGAGTGTGACGGGGATTGCTAAGGGGATAAAGGAGA TTGTTGAAGCTGCTGGGGACAGTGAGGCTGCTAGCAAGGCAGCTGGTGCTGTTAGTGCTGTTAG TGGGGAGCAGATATTAAGTGCGATTGTTAAGGCTGCGGCTGCTGGTGCGGCTGAGCAGGATGG AGAGAAGCCTGCAGAGGCTAAAAATCCGATTGCTGCTGCTATTGGGAAGGGTGATGGGGATGC GGATTTTGGTGAGGATGGGATGAAGAAGGATGATCAGATTGCTGCTGCTATTGCTTTGAGGGG GATGGCTAAGGATGGAAAGTTTGCTGTGAAGAATGATGAGAAAGGGAAGGCTGAGGGGGCTAT TAAGGGAGCTGCTGCAATTGGAGAAGTTGTGGATAATGCTGGTGCTGCGAAGGCTGCTGATAA GGATAGTGTGAAGGGGATTGCTAAGGGGATAAAGGAGATTGTTGAAGCTGCTGGGGGGAGTGA AAAGCTGAAAGCTGCTGCTGCTGAAGGGGAGAATAATAAAAAGGCAGGGAAGTTGTTTGGGAA AGTTGATGGTGCTGCTGGGGACAGTGAGGCTGCTAGCAAGGCGGCTGGTGCTGTTAGTGCTGTT AGTGGGGAGCAGATATTAAGTGCGATTGTTAAGGCTGCGGATGCGGCTGAGCAGGATGGAAAG AAGCCTGCAGATGCTACAAATCCGATTGCTGCTGCTATTGGGAATAAAGATGAGGATGCGGATT TTGGTGATGGGATGAAGAAGGATGATCAGATTGCTGCTGCTATTGCTTTGAGGGGGATGGCTA AGGATGGAAAGTTTGCTGTGAAGGGTAATAATGAGAAAGGGAAGGCTGAGGGGGCTTCAAGTG GTACTGATGCAATTGGAGAAGTTGTGGATAATGATGCGAAGGCTGCTGATAAGGCGAGTGTGA CGGGGATTGCTAAGGGGATAAAGGAGATTGTTGAAGCTGCTGGGGGGAGTGAAAAGCTGAAA GCTGTTGCTGCTGCTACAAGGGAGAATAATAAAGAGGCAGGGAAGTTGTTTGGGAAAGTTGAT GATGCTCATGCTGGGGACAGTGAGGCTGCTAGCAAGGCGGCTGGTGCTGTTAGTGCTGTTAGTG GGGAGCAGATATTAAGTGCGATTGTTACGGCTGCGGCTGCTGGTGAGCAGGATGGAGAGAAGC CTGCAGAGGCTACAAATCCGATTGCTGCTGCTATTGGGAAGGGTAATGAGGATGGTGCGGATTT TGGTAAGGATGAGATGAAGAAGGATGATCAGATTGCTGCTGCTATTGCTTTGAGGGGGATGGC TAAGGATGGAAAGTTTGCTGTGAAGAGTAATGATGGTGAGAAAGGGAAGGCTGAGGGGGCTAT TAAGGAAGTTAGCGAGTTGTTGGATAAGCTGGTAAAAGCTGTAAAGACAGCTGAGGGGGCTTC AAGCGGTACTGATGCAATTGGAGAAGTTGTGGCTAATGCTGGTGCTGCGAAGGCTGCTGATAA GGCGAGTGTGACGGGGATTGCTAAGGGGATAAAGGAGATTGTTGAAGCTGCTGGGGGGAGTAA AAAGCTGAAAGCTGCTGCTGCTGAAGGGGAGAATAATAAAAAGGCAGGGAAGTTGTTTGGGAA GGCTGGTGCTGGTGCTGGTGCTAATGGGGACAGTGAGGCTGCTAGCAAGGCGGCTGGTGCTGT TAGTGCTGGTTAG t24-1.nt (SEQ ID NO:630) TGGTGAGGCTGAGCAGGATGGAGAGAAGCCTGAGGATGCTAAAAATCCGATTGCTGCTGCTAT TGGGAAGGGTAATGGGGATGGTGCGGAGTTTGATCAGGATGAGATGAAGAAGGATGATCAGAT TGCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAAGTTTGCTGTGAAGGGTAATAAT GAGAAAGAGAAGGCTGAGGGGGCTATTAAAGAAGTTAGCGAGTTGTTGGATAAGCTGGTAACA GCTGTAAAGACAGCTGAGGGGGCTTCAAGTGGTACTGATGCAATTGGAGAAGTTGTGGATAAT GNTGCNAAGGNTGCTGATAAGGCGAGTGTGACGGGGATTGCTAAGGGGATAAAGGAGATTGTT GAAGCTGCTNGGGGGAGTGAAAAGCTGAAAGTTGCTGCTGCTANAGNGGNNAATAATAAAGA GGCAGGGAAGTTGTTTGGGAAGGCTGGTGCTGATGCTAATGGGGACAGTGAGGCTGCTAGCAA G f24-1.aa (SEQ ID NO:631) AGNTVKTAEGASSGTDAIGEVVDNDAKVADKASVTGIAKGIKEIVEAARGSEKLKVAAAKEGNEK AGKLFGKAGANAHGDSEAASKAAGAVSAVSGEQILSAIVKAADAAEQDGKKPADATNPIAAAIGN KDEDADFGDGMKKDDQIAAAIALRGMAKDGKFAVKNDEKGKAEGAIKGAAAIGEVVDNAGAAK AADKDSVKGIAKGIKEIVEAAGGSEKLKAAAAEGENNKKAGKLFGKVDGAAGDSEAASKAAGAVS AVSGEQILSAIVKAAGEAEQDGEKPEDAKNPIAAAIGKGNGDGAEFDQDEMKKDDQIAAAIALRGM AKDGKFAVKGNNEKEKAEGAIKEVSELLDKLVTAVKTAEGASSGTDAIGEVVDNXAKXADKASVT GIAKGIKEIVEAAXGSEKLKVAAAXXXNNKEAGKLFGKAGADANGDSEAASKAAGAVSAVSGEQI LSAIVKAAAAGAADQDGEKPGDAKNPIAAAIGKGNADDGADFGDGMKKDDQIAAAIALRGMAKD GKFAVKKDEKGKAEGAIKGASELLDKLVKAVKTAEGASSGTAAIGEVVDNAAKAADKDSVTGIAK GIKEIVEAAGGSEKLKVAAAKGENNKGAGKLFGKAGANAHGDSEAASKAAGAVSAVSGEQILSAIV KAAGEAAGDQEGKKPEEAKNPIAAAIGDKDGDAEFNQDGMKKDDQIAAAIALRGMAKDGKFAVK DGGEKEKAEGAIKGVSELLDKLVKAVKTAEGASSGTAAIGEVVADAAKVADKASVTGIAKGIKEIV EAAGDSEAASKAAGAVSAVSGEQILSAIVKAAAAGAAEQDGEKPAEAKNPIAAAIGKGDGDADFGE DGMKKDDQIAAAIALRGMAKDGKFAVKNDEKGKAEGAIKGAAAIGEVVDNAGAAKAADKDSVK GIAKGIKEIVEAAGGSEKLKAAAAEGENNKKAGKLFGKVDGAAGDSEAASKAAGAVSAVSGEQILS AIVKAADAAEQDGKKPADATNPIAAAIGNKDEDADFGDGMKKDDQIAAAIALRGMAKDGKFAVK GNNEKGKAEGASSGTDAIGEVVDNDAKAADKASVTGIAKGIKEIVEAAGGSEKLKAVAAATRENN KEAGKLFGKVDDAHAGDSEAASKAAGAVSAVSGEQILSAIVTAAAAGEQDGEKPAEATNPIAAAIG KGNEDGADFGKDEMKKDDQIAAAIALRGMAKDGKFAVKSNDGEKGKAEGAIKEVSELLDKLVKA VKTAEGASSGTDAIGEVVANAGAAKAADKASVTGIAKGIKEIVEAAGGSIKLKAAAAEGENNKKA GKLFGKAGAGAGANGDSEAASKAAGAVSAG t24-1.aa (SEQ ID NO:632) GEAEQDGEKPEDAKNPIAAAIGKGNGDGAEFDQDEMKKDDQIAAAIALRGMAKDGKFAVKGNNE KEKAEGAIKEVSELLDKLVTAVKTAEGASSGTDAIGEVVDNXAKXADKASVTGIAKGIKEIVEAAX GSEKLKVAAAXXXNNKEAGKLFGKAGADANGDSEAASK f28-2.nt (SEQ ID NO:633) TAAAAAGGAAATATAAATATTATGCGATTATGTTTAATAAAAATTTTTATTATACCTAATTTAG TATTTAGTTCTCTTTTTTTATTTGAAAGTTGTTCTGGTTTTCTATCTAAAAAATCTATAGAACAG TTTGCATTAGCATTAAAAGATCATCAAGAAAATAAAAATACTACTAATACTTCAGTAGATAAAA ATAGTAAGGAAATTGAATCTCCTAAAGACGTTACATCATCAAATAAAAAAACTTATGATCCAAT CTTACAAGTAGGTTCTAATCAACATATGTCAGATGATCCTGGTGCTAATAATAAAGAATCCCTA CCAAATTCAAGTCCAGCAATAATACAAAATGACTCGCATGCTCAAAATAATGTAAAGATGGAA GAAAATAAATCAGCTACTCCACAACATGATCCAATTGAACAAAGTAATTTTAAAAATAGCCTTA CTACAACAAGTAAAACTCCTGCTATTCCTTCAGAAGAAGAAATTAAAGCTAACTTAGATGAATT TGCACAAGAAGAGTATGAGCAAACATCTCTTTCAGAAATTAAAAATGCCACGCAAATTGTTAAT CATGCTAATCCTGAAAACAAATTAAACAATACACTCCTTGAGTTTGAAAAAGATTATGAAACTT TATCAAACTTGTTATTCTCTAATTTAGACGCATCTCCTTTGAATAGAAAAATAAAGACTATTATG CCTAAATTACAAGAAATGCGTTCTTTTATGGAGCAAGCAACTAATTCTTGGGTATCTGCTAAAG GCATGCTAGATGAGGCTAAGGATAAACTAGCAGAATCTATTTATAAAAGACTATACAATGGCA ATTCATACCGGTTCGGTGGCAGTTTTAACGGACGTGATATGCAACATGCAAAAAATTTAGCATA CAGAGCTATAGACTTTGCTTCTGCATGCATTGAATATACACAAAAAGCTATTGATTATCTTCAA CAGGGAAATTCTTGCAAAAAAGAAATAGAAAATATATTCAAGCTTTAA t28-2.nt (SEQ ID NO:634) AAAAGATCATCAAGAAAATAAAAATACTACTAATACTTCAGTAGATAAAAATAGTAAGGAAAT TGAATCTCCTAAAGACGTTACATCATCAAATAAAAAAACTTATGATCCAATCTTACAAGTAGGT TCTAATCAACATATGTCAGATGATCCTGGTGCTAATAATAAAGAATCCCTACCAAATTCAAGTC CAGCAATAATACAAAATGACTCGCATGCTCAAAATAATGTAAAGATGGAAGAAAATAAATCAG CTACTCCACAACATGATCCAATTGAACAAAGTAATTTTAAAAATAGCCTTACTACAACAAGTAA AACTCCTGCTATTCCTTCAGAAGAAGAAATTAAAGCTAACTTAGATGAATTTGCACAAGAAGAG TATGAGCAAACATCTCTTTCAGAAATTAAAAATGCCACGCAAATTGTTAATCATGCTAATCCTG AAAACAAATTAAACAATACACTCCTTGAGTTTGAAAAAGATTATGAAACTTTATCAAACTTGTT ATTCTCTAATTTAGACGCATCTCCTTTGAATAGAAAAATAAAGACTATTATGCCTAAATTACAA GAAATGCGTTCTTTTATGGAGCAAGCAACTAATTCTTGGGTATCTGCTAAAGGCATGCTAGATG AGGCTAAGGATAAACTAGCAGAATCTATTTATAAAAGACTATACAATGGCAATTCATACCGGTT CGGTGGCAGTTTTAACGGACGTGATATGCAACATGCAAAAAATTTAGCATACAGAGCTATAGA CTTTGCTTCTGCATGCATTGAATATACACAAAAAGCTATTGATTATCTTCAACAGGGAAATTCTT GCAAAAAAGAAATAGAAAATATATTCAAG f28-2.aa (SEQ ID NO:635) KGNINIMRLCLIKIFIIPNLVFSSLFLFESCSGFLSKKSIEQFALALKDHQENKNTTNTSVDKNSKEIESP KDVTSSNKKTYDPILQVGSNQHMSDDPGANNKESLPNSSPAIIQNDSHAQNNVKMEENKSATPQHD PIEQSNFKNSLTTTSKTPAIPSEEEIKANLDEFAQEEYEQTSLSEIKNATQIVNHANPENKLNNTLLEFE KDYETLSNLLFSNLDASPLNRKIKTIMPKLQEMRSFMEQATNSWVSAKGMLDEAKDKLAESIYKRL YNGNSYRFGGSFNGRDMQHAKNLAYRAIDFASACIEYTQKAIDYLQQGNSCKKEIENIFKL t28-2.aa (SEQ ID NO:636) KDHQENKNTTNTSVDKNSKEIESPKDVTSSNKKTYDPILQVGSNQHMSDDPGANNKESLPNSSPAII QNDSHAQNNVKMEENKSATPQHDPIEQSNFKNSLTTTSKTPAIPSEEEIKANLDEFAQEEYEQTSLSE IKNATQIVNHANPENKLNNTLLEFEKDYETLSNLLFSNLDASPLNRKIKTIMPKLQEMRSFMEQATN SWVSAKGMLDEAKDKLAESIYKRLYNGNSYRFGGSFNGRDMQHAKNLAYRAIDFASACIEYTQKA IDYLQQGNSCKKEIENIFK f28-3.nt (SEQ ID NO:637) TAGATGAATTTAATTGCTAAATTATTTATTTTATCCACTTTAGTTTCAATTCCAAATATCCTCTCT TGTAACCTATATGATAATCTTGCAGACAACGCTGAGCAGGTTACAGACATACTAGACAACAACA AGTCTTTTAATACTTTAGGAAGCAGCAATGAGAGTAGAAGTCGCAGGCCTAGAAGTACAAATA ATGCTTATATGAAACAAAACATAGACAAAAATCATTTAGTTGTTGCAGATATGCAAAATGATAA TAGTAGCAGCAGTCTTCCCCAACAAGTTAATAGTGAATCCAGTAAAGCTAATGAAGATAGTAAT ATTATGAAGGAAATTGAATCTTCTACAGAAGAGTGCGCTAGACTAAGAAAAGATTTAGAAACT ATAAAACAAATACTTGATAATATAGAAAGCTTGCTTAATACAGCTAATTCTTATTTAGAGAACG CTAGAAAAGCACCTAAATCTAATCAAGATAATCAAACCTTATTGCTTAGCCTGCACCAAGCTAT TGCTAAGGTTAAGAGTAGTCATACTTCTTTTATCATTTGTTATAATGATGCATTTAATTCCCTGG GAATAGCTGATACTGCCTTTAAAGATGCAAAGAGAAAGGCAGTTGAGGCATAA t28-3.nt (SEQ ID NO:638) TTGTAACCTATATGATAATCTTGCAGACAACGCTGAGCAGGTTACAGACATACTAGACAACAAC AAGTCTTTTAATACTTTAGGAAGCAGCAATGAGAGTAGAAGTCGCAGGCCTAGAAGTACAAAT AATGCTTATATGAAACAAAACATAGACAAAAATCATTTAGTTGTTGCAGATATGCAAAATGATA ATAGTAGCAGCAGTCTTCCCCAACAAGTTAATAGTGAATCCAGTAAAGCTAATGAAGATAGTAA TATTATGAAGGAAATTGAATCTTCTACAGAAGAGTGCGCTAGACTAAGAAAAGATTTAGAAAC TATAAAACAAATACTTGATAATATAGAAAGCTTGCTTAATACAGCTAATTCTTATTTAGAGAAC GCTAGAAAAGCACCTAAATCTAATCAAGATAATCAAACCTTATTGCTTAGCCTGCACCAAGCTA TTGCTAAGGTTAAGAGTAGTCATACTTCTTTTATCATTTGTTATAATGATGCATTTAATTCCCTG GGAATAGCTGATACTGCCTTTAAAGATGCAAAGAGAAAGGCAGTTGAGGCA f28-3.aa (SEQ ID NO:639) MNLIAKLFILSTLVSIPNILSCNLYDNLADNAEQVTDILDNNKSFNTLGSSNESRSRRPRSTNNAYMK QNIDKNHLVVADMQNDNSSSSLPQQVNSESSKANEDSNIMKEIESSTEECARLRKDLETIKQILDNIE SLLNTANSYLENARKAPKSNQDNQTLLLSLHQAIAKVKSSHTSFIICYNDAFNSLGIADTAFKDAKR KAVEA t28-3.aa (SEQ ID NO:640) CNLYDNLADNAEQVTDILDNNKSFNTLGSSNESRSRRPRSTNNAYMKQNIDKNHLVVADMQNDNS SSSLPQQVNSESSKANEDSNIMKEIESSTEECARLRKDLETIKQILDNIESLLNTANSYLENARKAPKS NQDNQTLLLSLHQAIAKVKSSHTSFIICYNDAFNSLGIADTAFKDAKRKAVEA f31-2.nt (SEQ ID NO:641) TAAAAAAATAAGGAGGTATTAATGAAAAGGAAAAGCAATATATGTATTTCACTTCTAG TCACAATATTATTTGTGTCTTGCAAGTTTTTTGGAAATAAAAGCGCAAGTAAAGAAAAAGAAGA AACTTCTTTTTCTGATACTGCTAGCAAGATTAGTAAGTCGGGAACAGCTGCTTCTTCAGACAAA CAAGAAAAAAATACAAGTGATGTTACAGGTGACGCCAAAAAGCATACTAGTAGCCCTTACATG CTTGCTGATGCCCTTATTGTTAGTGATACTACTAATAGAGATAGAGATAAGCAAGAAAATAAAG ATAAATTAAATGAAGAAGATAAAAAAAAGCTTAATGCTTTTTTTAGCACAACTAAAACATATCA ATCTAGCCTAGATTCCATTTATAACAAATATACAGGCTATTATAATACCATTGATACCTATGGC AGCTGTGATACGTATCGCATTGAGTGTTTTAGTGTAGGACCTTCTGAAAAACGTAAACAAGCTC TTGCTGATCTAGAGAAGTTAAAACTAGACGAAAAGTACACTCAGCTTAGCACAATGTTAAAGA GTGCTGTGCCTAGTTATTACAAAAAAAATTTAGATGATTCTATTGCACAGTATAAGGAAGCCAT AAAGCAGGCTATTGAAGCTGAAAGTAAAATAGAGACAGTAAAAGACTATGCAACAGCTCAAAG TGCTGCCGATGACGAAAAGAAAAGAAATATAGATAATTTAAAAATAGTTAGAGATGTTCTTCTT ATTATTAAAAAAACTATTGAGAAAGCCAGCCGATCTTATGCTGATGCTTTTGCTATTGCAACAT CTAGCTTATCTTGTAGCGAATTTAAGCAAGCTGTTAAAGAGTTTAATGATGCTGCTAAACAATA TGCTAATGGAAATAAAGGAGACAATGCTGTCAATGTTATTGTAGGCACTATTTCTAGTATGCCT TATGTCAAATTTAAAGATGAGTTTGCAAGAGCAAAAATGTTTGCTCGTAATTATAGAGGAGACG AGGTAGACAAGATGATAAGAGCTATCGACAAGCTGTGTGATGTTTATAAAAAAGTTGCGCTTTA G t31-2.nt (SEQ ID NO:642) TTGCAAGTTTTTTGGAAATAAAAGCGCAAGTAAAGAAAAAGAAGAAACTTCTTTTTCTGATACT GCTAGCAAGATTAGTAAGTCGGGAACAGCTGCTTCTTCAGACAAACAAGAAAAAAATACAAGT GATGTTACAGGTGACGCCAAAAAGCATACTAGTAGCCCTTACATGCTTGCTGATGCCCTTATTG TTAGTGATACTACTAATAGAGATAGAGATAAGCAAGAAAATAAAGATAAATTAAATGAAGAAG ATAAAAAAAAGCTTAATGCTTTTTTTAGCACAACTAAAACATATCAATCTAGCCTAGATTCCAT TTATAACAAATATACAGGCTATTATAATACCATTGATACCTATGGCAGCTGTGATACGTATCGC ATTGAGTGTTTTAGTGTAGGACCTTCTGAAAAACGTAAACAAGCTCTTGCTGATCTAGAGAAGT TAAAACTAGACGAAAAGTACACTCAGCTTAGCACAATGTTAAAGAGTGCTGTGCCTAGTTATTA CAAAAAAAATTTAGATGATTCTATTGCACAGTATAAGGAAGCCATAAAGCAGGCTATTGAAGC TGAAAGTAAAATAGAGACAGTAAAAGACTATGCAACAGCTCAAAGTGCTGCCGATGACGAAAA GAAAAGAAATATAGATAATTTAAAAATAGTTAGAGATGTTCTTCTTATTATTAAAAAAACTATT GAGAAAGCCAGCCGATCTTATGCTGATGCTTTTGCTATTGCAACATCTAGCTTATCTTGTAGCG AATTTAAGCAAGCTGTTAAAGAGTTTAATGATGCTGCTAAACAATATGCTAATGGAAATAAAGG AGACAATGCTGTCAATGTTATTGTAGGCACTATTTCTAGTATGCCTTATGTCAAATTTAAAGAT GAGTTTGCAAGAGCAAAAATGTTTGCTCGTAATTATAGAGGAGACGAGGTAGACAAGATGATA AGAGCTATCGACAAG f31-2.aa (SEQ ID NO:643) KNKEVLMKRKSNICISLLVTILFVSCKFFGNKSASKEKEETSFSDTASKISKSGTAASSDKQEKNTSD VTGDAKKHTSSPYMLADALIVSDTTNRDRDKQENKDKLNEEDKKKLNAFFSTTKTYQSSLDSIYNK YTGYYNTIDTYGSCDTYRIECFSVGPSEKRKQALADLEKLKLDEKYTQLSTMLKSAVPSYYKKNLD DSIAQYKEAIKQAIEAESKIETVKDYATAQSAADDEKKRNIDNLKIVRDVLLIIKKTIEKASRSYADAF AIATSSLSCSEFKQAVKEFNDAAKQYANGNKGDNAVNVIVGTISSMPYVKFKDEFARAKMFARNY RGDEVDKMIRAIDKLCDVYKKVAL t31-2.aa (SEQ ID NO:644) CKFFGNKSASKEKEETSFSDTASKISKSGTAASSDKQEKNTSDVTGDAKKHTSSPYMLADALIVSDT TNRDRDKQENKDKLNEEDKKKLNAFFSTTKTYQSSLDSIYNKYTGYYNTIDTYGSCDTYRIECFSV GPSEKRKQALADLEKLKLDEKYTQLSTMLKSAVPSYYKKNLDDSIAQYKEAIKQAIEAESKIETVKD YATAQSAADDEKKRNIDNLKIVRDVLLIIKKTIEKASRSYADAFAIATSSLSCSEFKQAVKEFNDAAK QYANGNKGDNAVNVIVGTISSMPYVKFKDEFARAKMFARNYRGDEVDKMIRAIDK f32-4.nt (SEQ ID NO:645) TAAGGAAATATGAGGAATATTAGCAATTGTATCAAATATATTATATTAACAATGCTTATTGGAT TATTAATTTTTTGTTGTGCAACCTTTGTTTGGTTGATTGGAATTTTTTATTCAAATAACTTTAAA GAAGAGCGGAATTATTCAATAAGCCCAATAGATAGTGTTATTATGCGTAAATGTTATTTTAAAG AATTTAAGTCTGGACTTATTAAAAGCGTATTCTTTAAGAAATTAGATGTAAATGTTAACTCTAA AAATTTTAAGGAGCTAAATAAGGTAGATAAACAAAATCTGCTAAATTCTTATCCATCTTATCAT ATGGAGTTTGTCGTAGTTGATAATGGATTTTTAATGAATTTTAAAAATGTTATTTTTAATGGTAT AGATGATGCTAAATTATACGATCAACGTGATATGGTTTACGGAGGATTTAGATACTCAAAAGAG GCTTATTTCCAAATTATTGGCAATTATGATGTTAAATTAAATAAAATGAACAATATACTCCAG CAATTGTAGTAAATGTTTTCAAAATTAACATTAATGATGCTTTATTTAACTCGTTATTAAAGCAA AAAACTTTAAAAGTTACTTTGATTTCCCATAATAATAAAGAGTATATTTTACAAACTAATAATTT CTTATCAAAGTATAATTTTCAAACACCAGAAAAGGAGAATAGTTCTTACTAA t32-4.nt (SEQ ID NO:646) AAATAACTTTAAAGAAGAGCGGAATTATTCAATAAGCCCAATAGATAGTGTTATTATGCGTAAA TGTTATTTTAAAGAATTTAAGTCTGGACTTATTAAAAGCGTATTCTTTAAGAAATTAGATGTAA ATGTTAACTCTAAAAATTTTAAGGAGCTAAATAAGGTAGATAAACAAAATCTGCTAAATTCTTA TCCATCTTATCATATGGAGTTTGTCGTAGTTGATAATGGATTTTTAATGAATTTTAAAAATGTTA TTTTTAATGGTATAGATGATGCTAAATTATACGATCAACGTGATATGGTTTACGGAGGATTTAG ATACTCAAAAGAGGCTTATTTCCAAATTATTGGCAATTATGATGTTAAATTAAATAAAATGAAA CAATATACTCCAGCAATTGTAGTAAATGTTTTCAAAATTAACATTAATGATGCTTTATTTAACTC GTTATTAAAGCAAAAAACTTTAAAAGTTACTTTGATTTCCCATAATAATAAAGAGTATATTTTA CAAACTAATAATTTCTTATCAAAGTATAATTTTCAAACACCAGAAAAGGAGAATAGTTCTTAC f32-4.aa (SEQ ID NO:647) GNMRNISNCIKYIILTMLIGLLIFCCATFVWLIGIFYSNNFKEERNYSISPIDSVIMRKCYFKEFKSGLIK SVFFKKLDVNVNSKNFKELNKVDKQNLLNSYPSYHMEFVVVDNGFLMNFKNVIFNGIDDAKLYDQ RDMVYGGFRYSKEAYFQIIGNYDVKLNKMKQYTPAIVVNVFKININDALFNSLLKQKTLKVTLISHN NKEYILQTNNFLSKYNFQTPEKENSSY t32-4.aa (SEQ ID NO:648) NNFKEERNYSISPIDSVIMRKCYFKEFKSGLIKSVFFKKLDVNVNSKNFKELNKVDKQNLLNSYPSY HMEFVVVDNGFLMNFKNVIFNGIDDAKLYDQRDMVYGGFRYSKEAYFQIIGNYDVKLNKMKQYT PAIVVNVFKININDALFNSLLKQKTLKVTLISHNNKEYILQTNNFLSKYNFQTPEKENSSY f4-15.nt (SEQ ID NO:649) TAAATGAGCAAAAAAGTAATTTTAATATTACTAGAAATTTTGATCTTGTCTTGTGATTTATCTAT AAATAAAGAACAAAAAACCAAAGAAAAAACATCTGAAAAGCAAGAATCTGAAAAACAAAATA TTGAAAAACAAGAGCCTGAAAAACAGAAACAAAATGCAGCAAAAATAATCCCTACGGTATCAA TTCAAACGGTAGAAATAAGGGAATCAAATCAAATTCCAAAAAGCATTGAGAAGTACTACAAGC AAGCTTATCCGATTCAAACATTCACTCTTGATTTTAGCATCACAAGAGAAAAGGAATTTCTAAA ACCAGAAGATAAAATCTTGCCCACACAGGGGAAAGTGGAGTCTTTGAGCATCTTAATAAATAA AAAATTGTTAGACTTTAAAGCCCCAGAAAATCCAAAAAGCTCAACTTTAAAAAATTTCAAAGAA ATTAAAAATATTGAGAATTTCTTCCAAAATCAAGACTTATTATTTGTCTTAACCCTTAAAGATAA AAATAACAACAACACTATTAACATCATGCTCAATCCCCCAAACGACATCCAAAAACCCAAAGAT TATATTTTAAAAGACCTTAAAGACACAATTAAAAAGGGTACTGGTGAGAAATACTTAAATCCTA TCTATAGATTTCAAATAAAAAACAAAAAAGATTATCATTCAATAGATTACAACAAAGTGACTAT TAGCGAAAAAACAATAGAATTGGACCTACTGCCTCACGAACAAGTCTTTCAAATGAATAAAAAT TTCACTAAAATTTTAGACACAATAACAGACTTAAATAATCTAAAATTAGTAATTCAAAAAGAAT TAGTGTAA t4-15.nt (SEQ ID NO:650) TTGTGATTTATCTATAAATAAAGAACAAAAAACCAAAGAAAAAACATCTGAAAAGCAAGAATC TGAAAAACAAAATATTGAAAAACAAGAGCCTGAAAAACAGAAACAAAATGCAGCAAAAATAAT CCCTACGGTATCAATTCAAACGGTAGAAATAAGGGAATCAAATCAAATTCCAAAAAGCATTGA GAAGTACTACAAGCAAGCTTATCCGATTCAAACATTCACTCTTGATTTTAGCATCACAAGAGAA AAGGAATTTCTAAAACCAGAAGATAAAATCTTGCCCACACAGGGGAAAGTGGAGTCTTTGAGC ATCTTAATAAATAAAAAATTGTTAGACTTTAAAGCCCCAGAAAATCCAAAAAGCTCAACTTTAA AAAATTTCAAAGAAATTAAAAATATTGAGAATTTCTTCCAAAATCAAGACTTATTATTTGTCTT AACCCTTAAAGATAAAAATAACAACAACACTATTAACATCATGCTCAATCCCCCAAACGACATC CAAAAACCCAAAGATTATATTTTAAAAGACCTTAAAGACACAATTAAAAAGGGTACTGGTGAG AAATACTTAAATCCTATCTATAGATTTCAAATAAAAAACAAAAAAGATTATCATTCAATAGATT ACAACAAAGTGACTATTAGCGAAAAAACAATAGAATTGGACCTACTGCCTCACGAACAAGTCTT TCAAATGAATAAAAATTTCACTAAA f4-15.aa (SEQ ID NO:651) MSKKVILILLEILILSCDLSINKEQKTKEKTSEKQESEKQNIEKQEPEKQKQNAAKIIPTVSIQTVEIRES NQIPKSIEKYYKQAYPIQTFTLDFSITREKEFLKPEDKILPTQGKVESLSILINKKLLDFKAPENPKSSTL KNFKEIKNIENFFQNQDLLFVLTLKDKNNNNTINIMLNPPNDIQKPKDYILKDLKDTIKKGTGEKYLN PIYRFQIKNKKDYHSIDYNKVTISEKTIELDLLPHEQVFQMNKNFTKILDTITDLNNLKLVIQKELV t4-15.aa (SEQ ID NO:652) CDLSINKEQKTKEKTSEKQESEKQNIEKQEPEKQKQNAAKIIPTVSIQTVEIRESNQIPKSIEKYYKQA YPIQTFTLDFSITREKEFLKPEDKILPTQGKVESLSILINKKLLDFKAPENPKSSTLKNFKEIKNIENFFQ NQDLLFVLTLKDKNNNNTINIMLNPPNDIQKPKDYILKDLKDTIKKGTGEKYLNPIYRFQIKNKKDY HSIDYNKVTISEKTIELDLLPHEQVFQMNKNFTK f4-50.nt (SEQ ID NO:653) TAGAAGGAGGAAAAAATGAAAATTGGAAAGCTAAATTCAATAGTTATAGCCTTGTTTTTTAAAC TATTGGTCGCATGTAGTATTGGATTAGTAGAAAGAACAAATGCAGCTCTTGAATCGTCCTCTAA GGATTTAAAAAACAAAATTTTAAAAATAAAAAAAGAAGCCACGGGAAAAGGTGTACTTTTTGA AGCTTTTACAGGTCTTAAAACCGGTTCCAAGGTAACAAGTGGTGGACTAGCCTTAAGAGAAGCA AAAGTACAAGCCATTGTTGAAACAGGAAAGTTCCTTAAGATAATAGAAGAAGAAGCTTTAAAG CTTAAAGAAACTGGAAACAGTGGTCAATTCTTGGCTATGTTTGACTTAATGCTTGAGGTTGTAG AATCGCTAGAAGACGTTGGAATAATAGGCTTAAAAGCCCGTGTTTTAGAGGAATCTAAAAATA ATCCTATAAACACAGCTGAAAGATTGCTTGCGGCTAAAGCTCAAATAGAAAATCAACTTAAAGT GGTTAAGGAAAAACAAAATATTGAAAATGGTGGAGAGAAAAAAAATAATAAAAGCAAAAAAA AGAAATAA t4-50.nt (SEQ ID NO:654) ATGTAGTATTGGATTAGTAGAAAGAACAAATGCAGCTCTTGAATCGTCCTCTAAGGATTTAAAA AACAAAATTTTAAAAATAAAAAAAGAAGCCACGGGAAAAGGTGTACTTTTTGAAGCTTTTACA GGTCTTAAAACCGGTTCCAAGGTAACAAGTGGTGGACTAGCCTTAAGAGAAGCAAAAGTACAA GCCATTGTTGAAACAGGAAAGTTCCTTAAGATAATAGAAGAAGAAGCTTTAAAGCTTAAAGAA ACTGGAAACAGTGGTCAATTCTTGGCTATGTTTGACTTAATGCTTGAGGTTGTAGAATCGCTAG AAGACGTTGGAATAATAGGCTTAAAAGCCCGTGTTTTAGAGGATCTAAAAATAATCCTATAAA CACAGCTGAAAGATTGCTTGCGGCTAAAGCTCAAATAGAAAATCAACTTAAAGTGGTTAAGGA AAAACAAAATATTGAAAATGGTGGAGAGAAAAAAAATAATAAAAGCAAAAAAAAGAAA f4-50.aa (SEQ ID NO:655) KEEKMKIGKLNSIVIALFFKLLVACSIGLVERTNAALESSSKDLKNKILKIKKEATGKGVLFEAFTGL KTGSKVTSGGLALREAKVQAIVETGKFLKIIEEEALKLKETGNSGQFLAMFDLMLEVVESLEDVGIIG LKARVLEESKNNPINTAERLLAAKAQIENQLKVVKEKQNIENGGEKKNNKSKKKK t4-50.aa (SEQ ID NO:656) CSIGLVERTNAALESSSKDLKNKILKIKKEATGKGVLFEAFTGLKTGSKVTSGGLALREAKVQAIVET GKFLKIIEEEALKLKETGNSGQFLAMFDLMLEVVESLEDVGIIGLKARVLEESKNNPINTAERLLAAK AQIENQLKVVKEKQNIENGGEKKNNKSKKKK f4-66.nt (SEQ ID NO:657) TAATTTTTAAAATTTAAATATTTACATAATAGTAATGTGTGTGGGAGACGTATGAAAAATATTT TATTATTTGTTATTTTATTATTCTTTTCTTGTAAAGAATTTAATTATTCTGATCTTAGGAGAAGG CCTTCAAAGGTTTTAAATGCTTCTAATGGTGCATCAAATAAAGAACTTAAAATTTCTTTTGTAG ATTCTTTAAATGATGATCAAAAAGAAGCTTTGTTTTTTCTTGAACAGGTAGTTCTTGATAGCAAT CCCGACAAGTTTAATCAAATTTTTAATTTAAATGAAGAGAAGGTAAAAGAAATGCTTGTTACTG TTGTTAAGTGTTTAAAGGCCAAAAGAAAGGCTAAAATGGCTCTTGAGAGCTCAAATGTTGCAA ATGTTGCCAATGCTAAACAGCAATTGCTACAGGTTGAAAAAACTTACATAGATAATTTGCGACA ATCTTTTATGACTACTAAAAACATTGAAGAGGCTTGTAATCTTGTAAAAAATTATGATGCATCT GCTTCGTTTTAA t4-66.nt (SEQ ID NO:658) TTGTAAAGAATTTAATTATTCTGATCTTAGGAGAAGGCCTTCAAAGGTTTTAAATGCTTCTAAT GGTGCATCAAATAAAGAACTTAAAATTTCTTTTGTAGATTCTTTAAATGATGATCAAAAAGAAG CTTTGTTTTTTCTTGAACAGGTAGTTCTTGATAGCAATCCCGACAAGTTTAATCAAATTTTTAAT TTAAATGAAGAGAAGGTAAAAGAAATGCTTGTTACTGTTGTTAAGTGTTTAAAGGCCAAAAGA AAGGCTAAAATGGCTCTTGAGAGCTCAAATGTTGCAAATGTTGCCAATGCTAAACAGCAATTGC TACAGGTTGAAAAAACTTACATAGATAATTTGCGACAATCTTTTATGACTACTAAAAACATTGA AGAGGCTTGTAATCTTGTAAAAAATTATGATGCATCTGCTTCGTTT f4-66.aa (SEQ ID NO:659) FLKFKYLHNSNVCGRRMKNILLFVILLFFSCKEFNYSDLRRRPSKVLNASNGASNKELKISFVDSLND DQKEALFFLEQVVLDSNPDKFNQIFNLNEEKVKEMLVTVVKCLKAKRKAKMALESSNVANVANAK QQLLQVEKTYIDNLRQSFMTTKNIEEACNLVKNYDASASF t4-66.aa (SEQ ID NO:660) CKEFNYSDLRRRPSKVLNASNGASNKELKISFVDSLNDDQKEALFFLEQVVLDSNPDKFNQIFNLNE EKVKEMLVTVVKCLKAKRKAKMALESSNVANVANAKQQLLQVEKTYIDNLRQSFMTTKNIEEAC NLVKNYDASASF f42-1.nt (SEQ ID NO:661) TAATTATTAAAATCTAAGGAGAAGAGATTTATGAACAAAAAATTTTCTATTTCATTATTATCTA CAATATTAGCCTTCTTGTTAGTATTAGGTTGTGATTTGTCAAGCAATAATGCTGAAAACAAAAT GGATGATATTTTTAATTTAGAAAAGAAATACATGGATAATTCAAATTATAAATGTTTAAGTAAA AATGAGGCTATAGTTAAAAATTCTAAAATTAAATTAGGTGTAAATAATACTAGAAGTCGTTCTT ATTCTTCTAGAGAGACTAATGTTTCGGATTCCTATAATAAAACCTATTCATATTGCAAAAGCAA CTGA t42-1.nt (SEQ ID NO:662) TTGTGATTTGTCAAGCAATAATGCTGAAAACAAAATGGATGATATTTTTAATTTAGAAAAGAAA TACATGGATAATTCAAATTATAAATGTTTAAGTAAAAATGAGGCTATAGTTAAAAATTCTAAAA TTAAATTAGGTGTAAATAATACTAGAAGTCGTTCTTATTCTTCTAGAGAGACTAATGTTTCGGA TTCCTATAATAAAACCTATTCATATTGCAAAAGCAAC f42-1.aa (SEQ ID NO:663) LLKSKEKRFMNKKFSISLLSTILAFLLVLGCDLSSNNAENKMDDIFNLEKKYMDNSNYKCLSKNEAI VKNSKIKLGVNNTRSRSYSSRETNVSDSYNKTYSYCKSN t42-1.aa (SEQ ID NO:664) CDLSSNNAENKMDDIFNLEKKYMDNSNYKCLSKNEAIVKNSKIKLGVNNTRSRSYSSRETNVSDSY NKTYSYCKSN f43-3.nt (SEQ ID NO:665) TGAATATTAATAATAAAAAAAGGAATAANAATGAAAATTATCAACATATTATTTTGTTTATTTT TACTAATGCTAAACAGCTGTAATTCTAATGATACTAATACTAGCCAAACAAAAAGTAGACAAAA ACGTGATTTAACCCAAAAAGAAGCAACACAAGAAAAACCAAAATCTAAAGAAGACCTGCTTAG AGAAAAGCTATCTGAAGACCAAAAAACACATCTTGACTGGTTAAAAACCGCTTTAACTGGTGCT GGAGAATTTGATAAATTTTTAGGATATGACGAAGACAAAATAAAAGGTGCACTTAATCATATA AAGAGTGAACTTGATAAGTGTACTGGGGATAATTCTGAACAACAAAAAAGCACCTTCAAAGAG GTGGTTAAGGGGGCTCTTGGTGGCGGTATAGATAGTTTTGCAACTAGTGCAAGTAGTACCTGCC AAGCTCAGCAATAA t43-3.nt (SEQ ID NO:666) CTGTAATTCTAATGATACTAATACTAGCCAAACAAAAAGTAGACAAAAACGTGATTTAACCCAA AAAGAAGCAACACAAGAAAAACCAAAATCTAAAGAAGACCTGCTTAGAGAAAAGCTATCTGAA GACCAAAAAACACATCTTGACTGGTTAAAAACCGCTTTAACTGGTGCTGGAGAATTTGATAAAT TTTTAGGATATGACGAAGACAAAATAAAAGGTGCACTTAATCATATAAAGAGTGAACTTGATA AGTGTACTGGGGATAATTCTGAACAACAAAAAAGCACCTTCAAAGAGGTGGTTAAGGGGGCTC TTGGTGGCGGTATAGATAGTTTTGCAACTAGTGCAAGTAGTACCTGCCAAGCTCAGCAA f43-3.aa (SEQ ID NO:667) ILIIKKGIXMKIINILFCLFLLMLNSCNSNDTNTSQTKSRQKRDLTQKEATQEKPKSKEDLLREKLSED QKTHLDWLKTALTGAGEFDKFLGYDEDKIKGALNHIKSELDKCTGDNSEQQKSTFKEVVKGALGG GIDSFATSASSTCQAQQ t43-3.aa (SEQ ID NO:668) CNSNDTNTSQTKSRQKRDLTQKEATQEKPKSKEDLLREKLSEDQKTHLDWLKTALTGAGEFDKFL GYDEDKIKGALNHIKSELDKCTGDNSEQQKSTFKEVVKGALGGGIDSFATSASSTCQAQQ f45-2.nt (SEQ ID NO:669) TAGGAGAGAATAATTATGAATAAAAAAACATTGATTATTTGTGCTGTTTTTGCGCTGATAATTT CTTGCAAGAATTTTGCAACTGGTAAAGATATAAAACAAAATTCAGAAGGGAAAATTAAAGGAT TTGTAAATAAGATTTTAGATCCAGTAAAGGATAAAATTGCTTCAAGTGGTACAAAAGTAGATGA AGTAGCAAAAAAATTACAAGAAGAAGAAAAAGAAGAATTAATGCAGGGCGATGATCCTAATGG CAGTGGAATAAATCCGCCACCAGTATTGCCGGAAAATATTCACAATAATGCATTAGTATTAAAA GCAATAGAACAAAGTGATGGTCAACAAGAAAAAAAAGTAGAAGAAGCTGAAGCTAAAGTTGA AGAAAATAAAGAAAAACAAGAGAATACAGAAGAAAACATTAAAGAAAAAGAAATAATAGACG AACAAAACAAACAAGAATTAGCTAAAGCTAAAGAAGAAGAACAACAAAAAGAACAAAAAAGA CATCAAGAAGAGCAACAAAGAAAAGCTAAAGCAGAAAAAGAAAAAAGAGAAAGAGAAGAGGC AGAACAACAAAAACGACAACAAGAAGAGGAAGAAAAAAGGCAAGTTGATAACCAAATTAAAA CACTTATAGCTAAAATAGATGAGATCAATGAAAATATTGATGTTATAAAATGGCAAACGACTGT AGGCCCACAAGGCGTTATAGATAGAATTACTGGGCCTGTGTATGATGATTTTACCAATGGCAAT AATTCTATACGCGAAACTTGGGAGGGGTTAGAAGAGGAATCAGAAGACGAAGGATTAGGAAAA TTATTGAAAGAATTGAGTGATGCTAGGGACGCGCTAAGAACTAAATTAAATGAAGGCAATAAA CCATATACTGGTTACGAAGAGCCTAAGTTAAAAGAAAGTGTAAATGTTAGCGAAATTAAAGAA GATTTAGAAAAATTAAAATCAAAATTAGAAGAAGTTAAAAAATATCTTAAAGATAGTTCTAAAT TTGAAGAAATTAAAGGATACATCAGTGACAGTCAGTAA t45-2.nt (SEQ ID NO:670) TTGCAAGAATTTTGCAACTGGTAAAGATATAAAACAAAATTCAGAAGGGAAAATTAAAGGATT TGTAAATAAGATTTTAGATCCAGTAAAGGATAAAATTGCTTCAAGTGGTACAAAAGTAGATGA AGTAGCAAAAAAATTACAAGAAGAAGAAAAAGAAGAATTAATGCAGGGCGATGATCCTAATGG CAGTGGAATAAATCCGCCACCAGTATTGCCGGAAAATATTCACAATAATGCATTAGTATTAAAA GCAATAGAACAAAGTGATGGTCAACAAGAAAAAAAAGTAGAAGAAGCTGAAGCTAAAGTTGA AGAAAATAAAGAAAAACAAGAGAATACAGAAGAAAACATTAAAGAAAAAGAAATAATAGACG AACAAAACAAACAAGAATTAGCTAAAGCTAAAGAAGAAGAACAACAAAAAGAACAAAAAAGA CATCAAGAAGAGCAACAAAGAAAAGCTAAAGCAGAAAAAGAAAAAAGAGAAAGAGAAGAGGC AGAACAACAAAAACGACAACAAGAAGAGGAAGAAAAAAGGCAAGTTGATAACCAAATTAAAA CACTTATAGCTAAAATAGATGAGATCAATGAAAATATTGATGTTATAAAATGGCAAACGACTGT AGGCCCACAAGGCGTTATAGATAGAATTACTGGGCCTGTGTATGATGATTTTACCAATGGCAAT AATTCTATACGCGAAACTTGGGAGGGGTTAGAAGAGGAATCAGAAGACGAAGGATTAGGAAAA TTATTGAAAGAATTGAGTGATGCTAGGGACGCGCTAAGAACTAAATTAAATGAAGGCAATAAA CCATATACTGGTTACGAAGAGCCTAAGTTAAAAGAAAGTGTAAATGTTAGCGAAATTAAAGAA GATTTAGAAAAATTAAAATCAAAATTAGAAGAAGTTAAAAAATATCTTAAAGATAGTTCTAAAT TTGAAGAAATTAAAGGATACATCAGTGACAGTCAG f45-2.aa (SEQ ID NO:671) ERIIMNKKTLIICAVFALIISCKNFATGKDIKQNSEGKIKGFVNKILDPVKDKIASSGTKVDEVAKKLQ EEEKEELMQGDDPNGSGINPPPVLPENIHNNALVLKAIEQSDGQQEKKVEEAEAKVEENKEKQENT EENIKEKEIIDEQNKQELAKAKEEEQQKEQKRHQEEQQRKAKAEKEKREREEAEQQKRQQEEEEKR QVDNQIKTLIAKIDEINENIDVIKWQTTVGPQGVIDRITGPVYDDFTNGNNSIRETWEGLEEESEDEG LGKLLKELSDARDALRTKLNEGNKPYTGYEEPKLKESVNVSEIKEDLEKLKSKLEEVKKYLKDSSKF EEIKGYISDSQ t45-2.aa (SEQ ID NO:672) CKNFATGKDIKQNSEGKIKGFVNKILDPVKDKIASSGTKVDEVAKKLQEEEKEELMQGDDPNGSGI NPPPVLPENIHNNALVLKAIEQSDGQQEKKVEEAEAKVEENKEKQENTEENIKEKEIIDEQNKQELA KAKEEEQQKEQKRHQEEQQRKAKAEKEKREREEAEQQKRQQEEEEKRQVDNQIKTLIAKIDEINEN IDVIKWQTTVGPQGVIDRITGPVYDDFTNGNNSIRETWEGLEEESEDEGLGKLLKELSDARDALRTK LNEGNKPYTGYEEPKLKESVNVSEIKEDLEKLKSKLEEVKKYLKDSSKFEEIKGYISDSQ f47-2.nt (SEQ ID NO:673) TGAATATTAATAATAAAAAAAGGAGTAACAATGAAAATCATCAACATATTATTTTGTATATCTT TGCTACTACTAAATAGCTGTAATTCCAATGATAATGACACTTTAAAAAACAATGCCCAACAAAC AAAAAGCAGGAAAAAACGTGATTTAAGCCAAGAAGAACTGCCACAACAAGAAAAAATCACTTT AACATCCGACGAAGAAAAAATGTTTACTTCATTAATCAATGTGTTTAAATACACAATTGAAAAA TTAAACAATGAAATACAAGGGTGCATGAATGGAAACAAAAGTAAATGTAATGACTTCTTTGATT GGCTTTCTGAAGATATTCAAAAACAAAAAGAATTAGCTGGTGCTTTTACCAAGGTTTACAACTT CTTAAAATCAAAAGCACAAAATGAAACTTTTGATACTTATATTAAAGGAGCTATTGATTGTAAA AAAAACACTCCACAAGATTGTAATAAAAATAATGAAATATGGGGAGGTGGACAACTTANTAGN GCAATATTTTAG t47-2.nt (SEQ ID NO:674) CTGTAATTCCAATGATAATGACACTTTAAAAAACAATGCCCAACAAACAAAAAGCAGGAAAAA ACGTGATTTAAGCCAAGAAGAACTGCCACAACAAGAAAAAATCACTTTAACATCCGACGAAGA AAAAATGTTTACTTCATTAATCAATGTGTTTAAATACACAATTGAAAAATTAAACAATGAAATA CAAGGGTGCATGAATGGAAACAAAAGTAAATGTAATGACTTCTTTGATTGGCTTTCTGAAGATA TTCAAAAACAAAAAGAATTAGCTGGTGCTTTTACCAAGGTTTACAACTTCTTAAAATCAAAAGC ACAAAATGAAACTTTTGATACTTATATTAAAGGAGCTATTGATTGTAAAAAAAACACTCCACAA GATTGTAATAAAAATAATGAA f47-2.aa (SEQ ID NO:675) ILIIKKGVTMKIINILFCISLLLLNSCNSNDNDTLKNNAQQTKSRKKRDLSQEELPQQEKITLTSDEEK MFTSLINVFKYTIEKLNNEIQGCMNGNKSKCNDFFDWLSEDIQKQKELAGAFTKVYNFLKSKAQNE TFDTYIKGAIDCKKNTPQDCNKNNEIWGGGQLXXAIF t47-2.aa (SEQ ID NO:676) CNSNDNDTLKNNAQQTKSRKKRDLSQEELPQQEKITLTSDEEKMFTSLINVFKYTIEKLNNEIQGCM NGNKSKCNDFFDWLSEDIQKQKELAGAFTKVYNFLKSKAQNETFDTYIKGAIDCKKNTPQDCNKN NE f49-2.nt (SEQ ID NO:677) TAAATGTTCAAAACAATCATTAAACAAAAAAATATGAAAAAAATTTCAAGTGCAATTTTATTAA CAACTTTCTTTGTTTTTATTAATTGTAAAAGCCAAGTTGCTGATAAGGCGAGTGTGACGGGGAT TGCTAAGGGAATAAAGGAGATTGTTGAAGCTGCTGGGGGGAGTGAAAAGCTGAAAGTTGCTGC TGCTGAAGGGGAGAATAATGAAAAGGCAGGGAAGTTGTTTGGGAAGGCTGGTGCTGGTAATGC TGGGGACAGTGAGGCTGCTAGCAAGGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAGCAGAT ATTAAGTGCGATTGTTAAGGCTGCTGGTGAGGCTGCGCAGGATGGAGAGAAGCCTGGGGAGGC TAAAAATCCGATTGCTGCTGCTATTGGGAAGGGTAATGAGGATGGTGCGGAGTTTAAGGATGA GATGAAGAAGGATGATCAGATTGCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAA GTTTGCTGTGAAGAATGATGAGAAAGGGAAGGCTGAGGGGGCTATTAAGGGAGCTGGCGAGTT GTTGGATAAGCTGGTAAAAGCTGTAAAGACAGCTGAGGGGGCTTCAAGTGGTACTGCTGCAAT TGGAGAAGTTGTGGCTGATGATAATGCTGCGAAGGTTGCTGATAAGGCGAGTGTGAAGGGGAT TGCTAAGGGGATAAAGGAGATTGTTGAAGCTGCTGGGGGGAGTAAAAAGCTGAAAGTTGCTGC TGCTAAAGAGGGCAATGAAAAGGCAGGGAAGTTGTTTGGGAAAGTTGATGCTGCTCATGCTGG GGACAGTGAGGCTGCTAGCAAGGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAGCAGATATT AAGTGCGATTGTTAAGGCTGCTGGTGCGGCTGCTGGTGATCAGGAGGGAAAGAAGCCTGGGGA TGCTAAAAATCCGATTGCTGCTGCTATTGGGAAGGGTGATGCGGAGAATGGTGCGGAGTTTAA TCATGATGGGATGAAGAAGGATGATCAGATTGCTGCTGCTATTGCTTTGAGGGGGATGGCTAA GGATGGAAAGTTTGCTGTGAAGAGTGGTGGTGGTGAGAAAGGGAAGGCTGAGGGGGCTATTAA GGGAGCTGCTGAGTTGTTGGATAAGCTGGTAAAAGCTGTAAAGACAGCTGAGGGGGCTTCAAG TGGTACTGATGCAATTGGAGAAGTTGTGGCTAATGCTGGTGCTGCAAAGGTTGCTGATAAGGC GAGTGTGACGGGGATTGCTAAGGGGATAAAGGAGATTGTTGAAGCTGCTGGGGGGAGTGAAAA GCTGAAAGTTGCTGCTGCTACAGGGGAGAGTAATAAAGGGGCAGGGAAGTTGTTTGGGAAGGC TGGTGCTGGTGCTAATGCTGGGGACAGTGAGGCTGCTAGCAAGGCGGCTGGTGCTGTTAGTGC TGTTAGTGGGGAGCAGATATTAAGTGCGATTGTTAAGGCTGCTGATGCGGCTGATCAGGAGGG AAAGAAGCCTGGGGATGCTANAAATCCGATTGCTGCTGCTATTGGGAAGGGTNATGNGGAGAA TGGTGCGGAGTTTAANNATGANGGATGA t49-2.nt (SEQ ID NO:678) TTGTAAAAGCCAAGTTGCTGATAAGGCGAGTGTGACGGGGATTGCTAAGGGAATAAAGGAGAT TGTTGAAGCTGCTGGGGGGAGTGAAAAGCTGAAAGTTGCTGCTGCTGAAGGGGAGAATAATGA AAAGGCAGGGAAGTTGTTTGGGAAGGCTGGTGCTGGTAATGCTGGGGACAGTGAGGCTGCTAG CAAGGCGGCTGGTGCTGTTAGTGCTGTTAGTGGGGAGCAGATATTAAGTGCGATTGTTAAGGCT GCTGGTGAGGCTGCGCAGGATGGAGAGAAGCCTGGGGAGGCTAAAAATCCGATTGCTGCTGCT ATTGGGAAGGGTAATGAGGATGGTGCGGAGTTTAAGGATGAGATGAAGAAGGATGATCAGATT GCTGCTGCTATTGCTTTGAGGGGGATGGCTAAGGATGGAAAGTTTGCTGTGAAGAATGATGAG AAAGGGAAGGCTGAGGGGGCTATTAAG f49-2.aa (SEQ ID NO:679) MFKTIIKQKNMKKISSAILLTTFFVFINCKSQVADKASVTGIAKGIKEIVEAAGGSEKLKVAAAEGEN NEKAGKLFGKAGAGNAGDSEAASKAAGAVSAVSGEQILSAIVKAAGEAAQDGEKPGEAKNPIAAAI GKGNEDGAEFKDEMKKDDQIAAAIALRGMAKDGKFAVKNDEKGKAEGAIKGAGELLDKLVKAVK TAEGASSGTAAIGEVVADDNAAKVADKASVKGIAKGIKEIVEAAGGSKKLKVAAAKEGNEKAGKL FGKVDAAHAGDSEAASKAAGAVSAVSGEQFLSAIVKAAGAAAGDQEGKKPGDAKNPIAAAIGKGD AENGAEFNHDGMKKDDQIAAAIALRGMAKDGKFAVKSGGGEKGKAEGAIKGAAELLDKLVKAVK TAEGASSGTDAIGEVVANAGAAKVADKASVTGIAKGIKEIVEAAGGSEKLKVAAATGESNKGAGK LFGKAGAGANAGDSEAASKAAGAVSAVSGEQILSAIVKAADAADQEGKKPGDAXNPIAAAIGKGX XENGAEFXXXG t49-2.aa (SEQ ID NO:680) CKSQVADKASVTGIAKGIKEIVEAAGGSEKLKVAAAEGENNEKAGKLFGKAGAGNAGDSEAASKA AGAVSAVSGEQILSAIVKAAGEAAQDGEKPGEAKNPIAAAIGKGNEDGAEFKDEMKKDDQIAAAIA LRGMAKDGKFAVKNDEKGKAEGAIK f5-14.nt (SEQ ID NO:681) TAGAAATTCAAAACAAAGGAGAAAACAAAAAGTATGAATAAAAAAATATTGATTATTTTTGCT GTTTTTGCACTTATAATTTCTTGTAAAAATTATGCAACTGGTAAAGATATAAAACAAAATGCAA AAGGGAAAATTAAAGGATTTTTAGATAAGGTTTTAGATCCAGCAAAAGATAAAATTACTTCAA GTAGTTCAAAAGTAGATGAATTAGCAAAAAAATTACAAGAAGAAGATGAAGATAATGAATTAA TGCAGGGCGATGATCCTAATAACAGAGCAATAGCACTGTTACCAGTATTGCCGGAAAATAGTC ATGACAATCCACCAGTACCAAAAGTAAAAGCAGCAGCACAAAGTGGTGGTCAACAAGAAGACC AAAAAGCAAAAGAATCTAAAGATAAAGTTGAGGAAGAAAAAGAAGTTGTAGAGGAGAAAAAA GAAGAACAAGATAGTAAAAAAGAAAAAGTGGAGAAGCAAAGTCAAAAGCAAAAAGAAGAAGA GAGAAACTCTAAAGAAGAACAACAAAAACAAGAAGAAGCAAAAGCTAGAGCAGATAGAGAAA GAGAAGAACGACTAAAACAACAAGAACAAAAAAGACAACAGGAAGAAGCTAGGGTTAAAGCA GAAAAAGAAAAACAAGAAAGAGAGGAACAACAAAAACAAGAAGAAGAAAAGAAAGTTAAATA TAAAATTAAAACACTTACAGACAAAATAGATGAAATAAATAAGGATATTGATGGTATAAATGG TAAAACAATTGTAGGAGCAGAAGAAGTTATAGATAAAATTACGGGGCCTGTATATGATGATTTT ACTGATGGGAATAAAGCTATATACAAAACTTGGGGAGATTTAGAGGATGAAGAAGGCGAAGAA TTAGGAAAATTATTGAAAGAATTGAGTGATACTAGACATAATTTAAGAACCAAATTAAATGAG GGTAATAAAGCATATATTGTTCTAGAAAAGGAGCCTAATTTAAAAGAAAATGTAAATGTTAGT GATATTCAATCAGATTTAGAAAAATTAAAATCAGGATTAGAAGAAGTTAAAAAATATTTTGAA AATGAAGATAATTTTGAAGAAATTAAAGGATACATTGAGGATAGTAATTCATATTGA t5-14.nt (SEQ ID NO:682) TTGTAAAAATTATGCAACTGGTAAAGATATAAAACAAAATGCAAAAGGGAAAATTAAAGGATT TTTAGATAAGGTTTTAGATCCAGCAAAAGATAAAATTACTTCAAGTAGTTCAAAAGTAGATGAA TTAGCAAAAAAATTACAAGAAGAAGATGAAGATAATGAATTAATGCAGGGCGATGATCCTAAT AACAGAGCAATAGCACTGTTACCAGTATTGCCGGAAAATAGTCATGACAATCCACCAGTACCAA AAGTAAAAGCAGCAGCACAAAGTGGTGGTCAACAAGAAGACCAAAAAGCAAAAGAATCTAAA GATAAAGTTGAGGAAGAAAAAGAAGTTGTAGAGGAGAAAAAAGAAGAACAAGATAGTAAAAA AGAAAAAGTGGAGAAGCAAAGTCAAAAGCAAAAAGAAGAAGAGAGAAACTCTAAAGAAGAAC AACAAAAACAAGAAGAAGCAAAAGCTAGAGCAGATAGAGAAAGAGAAGAACGACTAAAACAA CAAGAACAAAAAAGACAACAGGAAGAAGCTAGGGTTAAAGCAGAAAAAGAAAAACAAGAAAG AGAGGAACAACAAAAACAAGAAGAAGAAAAGAAAGTTAAATATAAAATTAAAACACTTACAG ACAAAATAGATGAAATAAATAAGGATATTGATGGTATAAATGGTAAAACAATTGTAGGAGCAG AAGAAGTTATAGATAAAATTACGGGGCCTGTATATGATGATTTTACTGATGGGAATAAAGCTAT ATACAAAACTTGGGGAGATTTAGAGGATGAAGAAGGCGAAGAATTAGGAAAATTATTGAAAGA ATTGAGTGATACTAGACATAATTTAAGAACCAAATTAAATGAGGGTAATAAAGCATATATTGTT CTAGAAAAGGAGCCTAATTTAAAAGAAAATGTAAATGTTAGTGATATTCAATCAGATTTAGAA AAATTAAAATCAGGATTAGAAGAAGTTAAAAAATATTTTGAAAATGAAGATAATTTTGAAGAA ATTAAAGGATACATTGAGGATAGTAATTCATAT f5-14.aa (SEQ ID NO:683) KFKTKEKTKSMNKKILIIFAVFALIISCKNYATGKDIKQNAKGKIKGFLDKVLDPAKDKITSSSSKVD ELAKKLQEEDEDNELMQGDDPNNRAIALLPVLPENSHDNPPVPKVKAAAQSGGQQEDQKAKESKD KVEEEKEVVEEKKEEQDSKKEKVEKQSQKQKEEERNSKEEQQKQEEAKARADREREERLKQQEQK RQQEEARVKAEKEKQEREEQQKQEEEKKVKYKIKTLTDKIDEINKDIDGINGKTIVGAEEVIDKITGP VYDDFTDGNKAIYKTWGDLEDEEGEELGKLLKELSDTRHNLRTKLNEGNKAYIVLEKEPNLKENV NVSDIQSDLEKLKSGLEEVKKYFENEDNFEEIKGYIEDSNSY t5-14.aa (SEQ ID NO:684) CKNYATGKDIKQNAKGKIKGFLDKVLKPAKDKITSSSSKVDELAKKLQEEDEDNELMQGDDPNNR AIALLPVLPENSHDNPPVPKVKAAAQSGGQQEDQKAKESKDKVEEEKEVVEEKKEEQDSKKEKVE KQSQKQKEEERNSKEEQQKQEEAKARADREREERLKQQEQKRQQEEARVKAEKEKQEREEQQKQ EEEKKVKYKIKTLTDKIDEINKDIDGINGKTIVGAEEVIDKITGPVYDDFTDGNKAIYKTWGDLEDEE GEELGKLLKELSDTRHNLRTKLNEGNKAYIVLEKEPNLKENVNVSDIQSDLEKLKSGLEEVKKYFEN EDNFEEIKGYIEDSNSY f5-15.nt (SEQ ID NO:685) TAACTTATGAATAAGAAAATGAAAATGTTTATTATTTGTGCTGTTTTTGCATTGATGATTTCTTG CAAGAATTATGCAAGTGGTGAAAATCTAAAAAATTCAGAACAAAATCTAGAAAGTTCAGAACA AAATGTAAAAAAAACAGAACAAGAGATAAAAAAACAAGTTGAAGGATTTTTAGAAATTCTAGA GACAAAAGATTTATCTAAATTAGATGAAAAAGATACAAAAGAAATTGAAAAACAAATTCAAGA ATTAAAGAATAAAATAGAAAAATTAGATTCTAAAAAAACTTCTATTGAAACATATTCTGAGTAT GAAGAAAAAATAAACAAAATAAAAGAAAAATTGAAAGGAAAAGGACTTGAAGATAAATTTAA GGAGCTTGAAGAGAGTTTAGCAAAGAAAAAGGGGGAGAGAAAAAAAGCTTTACAAGAGGCCA AACAGAAATTTGAAGAATATAAAAAACAAGTAGATACTTCAACTGGGAAAACTCAAGGCGACA GGTCTAAAAACCGAGGTGGTGTTGGAGTGCAAGCTTGGCAGTGTGCCAATGAATTAGGTTTGG GTGTAAGTTATTCTAATGGCGGCAGTGACAACAGCAATACTGATGAATTAGCAAACAAAGTTAT AGATGATTCTCTTAAAAAGATTGAAGAAGAACTTAAGGGAATAGAAGAAGATAAAAAAGAATA A t5-15.nt (SEQ ID NO:686) TTGCAAGAATTATGCAAGTGGTGAAAATCTAAAAAATTCAGAACAAAATCTAGAAAGTTCAGA ACAAAATGTAAAAAAAACAGAACAAGAGATAAAAAAACAAGTTGAAGGATTTTTAGAAATTCT AGAGACAAAAGATTTATCTAAATTAGATGAAAAAGATACAAAAGAAATTGAAAAACAAATTCA AGAATTAAAGAATAAAATAGAAAAATTAGATTCTAAAAAAACTTCTATTGAAACATATTCTGAG TATGAAGAAAAAATAAACAAAATAAAAGAAAAATTGAAAGGAAAAGGACTTGAAGATAAATTT AAGGAGCTTGAAGAGAGTTTAGCAAAGAAAAAGGGGGAGAGAAAAAAAGCTTTACAAGAGGC CAAACAGAAATTTGAAGAATATAAAAAACAAGTAGATACTTCAACTGGGAAAACTCAAGGCGA CAGGTCTAAAAACCGAGGTGGTGTTGGAGTGCAAGCTTGGCAGTGTGCCAATGAATTAGGTTT GGGTGTAAGTTATTCTAATGGCGGCAGTGACAACAGCAATACTGATGAATTAGCAAACAAAGT TATAGATGATTCTCTTAAAAAGATTGAAGAAGAACTTAAGGGAATAGAAGAAGATAAAAAAGA A f5-15.aa (SEQ ID NO:687) LMNKKMKMFIICAVFALMISCKNYASGENLKNSEQNLESSEQNVKKTEQEIKKQVEGFLEILETKDL SKLDEKDTKEIEKQIQELKNKIEKLDSKKTSIETYSEYEEKINKIKEKLKGKGLEDKFKELEESLAKK KGERKKALQEAKQKFEEYKKQVDTSTGKTQGDRSKNRGGVGVQAWQCANELGLGVSYSNGGSD NSNTDELANKVIDDSLKKIEEELKGIEEDKKE t5-15.aa (SEQ ID NO:688) CKNYASGENLKNSEQNLESSEQNVKKTEQEIKKQVEGFLEILETKDLSKLDEKDTKEIEKQIQELKN KIEKLDSKKTSIETYSEYEEKINKIKEKLKGKGLEDKFKELEESLAKKKGERKKALQEAKQKFEEYK KQVDTSTGKTQGDRSKNRGGVGVQAWQCANELGLGVSYSNGGSDNSNTDELANKVIDDSLKKIEE ELKGIEEDKKE f51-2.nt (SEQ ID NO:689) TAATTGTTTGGGGTTGTGGTAAACTTAAGGCTTATGGAGTGGATTATGAATAAAAAAATGAAAA TATTTATTATTTGTGCTGTATTTGTGCTGATAAGTTCTTGCAAGATTGATGCAACTGGTAAAGAT GCAACTGGTAAAGATGCAACTGGTAAAGATGCAACTGGTAAAGATGCAACTGGTAAAAATGCA GAACAAAATATAAAAGGGAAAGTTCAAGGATTTTTAGAAAAGATTTTAGATCCAGTAAAGGAT AAAATTGCTTCAAATGGTCCAATAGCAGATGAATTGGCAAAAAAATTACAAGAAGAAGAAAAG GTAAATAACGGGGAAGAAGAAAATGATAAAGCTGTCTTTTTAGGAGAAGAATCAAAAGAGGAT GAAGAAGAAAATGAGCAAGCTGTTAATTTAGAAGAAAAAAATGCGGAAGAGGATAAGAAAGT TGTTAATTTAGAAGAGAAAGAATTAGAAGTTAAAAAAGAGACTGAAGAAGATGAAGATAAAGA AGAAATAGAGAAACAAAAACAAGAAGTGGAAAAAGCACAAGAAAGAAAACAACGACAAGAAG AAAAGAAACGAAAAAAACAAGAACAGCAAGAAGAAAAGAAACGAAAACGACAAGAACAAAGA AAAGAAAGGAGAGCTAAAAACAAAATTAAAAAACTTGCGGATAAAATAGATGAGATAAGTTGG AATATTGATGGTATAGAAAGTCAAACAAGTGTAAAACCGAAAGCAGTTATAGATAAAATTACG GGGCCTGTATATGATTATTTTACCGATGACAACAAAAAAGCTATATATAAAACATGGGGAGATT TAGAAGATGAAGAAGGCGAAGGATTGGGAAAATTATTGAAAGAATTGAGTGATACTAGAGATG AGTTAAGAACCAAATTAAATAAAGATAATAAAAAATATTATGCCCATGAAAATGAGCCTCCTCT AAAAGAAAATGTAGATGTCAGCGAAATTAAAGAAGATTTAGAAAAAGTAAAATCAGGATTAGA AAAGGTTAAAGAATATCTTAAAGACAATTCTAAATTTGAAGAAATTAAAGGATACATCAGTTAC AGTCAGTAA t51-2.nt (SEQ ID NO:690) TTGCAAGATTGATGCAACTGGTAAAGATGCAACTGGTAAAGATGCAACTGGTAAAGATGCAAC TGGTAAAGATGCAACTGGTAAAAATGCAGAACAAAATATAAAAGGGAAAGTTCAAGGATTTTT AGAAAAGATTTTAGATCCAGTAAAGGATAAAATTGCTTCAAATGGTCCAATAGCAGATGAATT GGCAAAAAAATTACAAGAAGAAGAAAAGGTAAATAACGGGGAAGAAGAAAATGATAAAGCTG TCTTTTTAGGAGAAGAATCAAAAGAGGATGAAGAAGAAAATGAGCAAGCTGTTAATTTAGAAG AAAAAAATGCGGAAGAGGATAAGAAAGTTGTTAATTTAGAAGAGAAAGAATTAGAAGTTAAAA AAGAGACTGAAGAAGATGAAGATAAAGAAGAAATAGAGAAACAAAAACAAGAAGTGGAAAAA GCACAAGAAAGAAAACAACGACAAGAAGAAAAGAAACGAAAAAAACAAGAACAGCAAGAAGA AAAGAAACGAAAACGACAAGAACAAAGAAAAGAAAGGAGAGCTAAAAACAAAATTAAAAAAC TTGCGGATAAAATAGATGAGATAAGTTGGAATATTGATGGTATAGAAAGTCAAACAAGTGTAA AACCGAAAGCAGTTATAGATAAAATTACGGGGCCTGTATATGATTATTTTACCGATGACAACAA AAAAGCTATATATAAAACATGGGGAGATTTAGAAGATGAAGAAGGCGAAGGATTGGGAAAATT ATTGAAAGAATTGAGTGATACTAGAGATGAGTTAAGAACCAAATTAAATAAAGATAATAAAAA ATATTATGCCCATGAAAATGAGCCTCCTCTAAAAGAAAATGTAGATGTCAGCGAAATTAAAGA AGATTTAGAAAAAGTAAAATCAGGATTAGAAAAGGTTAAAGAATATCTTAAAGACAATTCTAA ATTTGAAGAAATTAAAGGATACATCAGTTACAGTCAG f51-2.aa (SEQ ID NO:691) LFGVVVNLRLMEWIMNKKMKIFIICAVFVLISSCKIDATGKDATGKDATGKDATGKDATGKNAEQN IKGKVQGFLEKILDPVKDKIASNGPIADELAKKLQEEEKVNNGEEENDKAVFLGEESKEDEEENEQA VNLEEKNAEEDKKVVNLEEKELEVKKETEEDEDKEEIEKQKQEVEKAQERKQRQEEKKRKKQEQQ EEKKRKRQEQRKERRAKNKIKKLADKIDEISWNIDGIESQTSVKPKAVIDKITGPVYDYFTDDNKKA IYKTWGDLEDEEGEGLGKLLKELSDTRDELRTKLNKDNKKYYAHENEPPLKENVDVSEIKEDLEKV KSGLEKVKEYLKDNSKFEEIKGYISYSQ t51-2.aa (SEQ ID NO:692) CKIDATGKDATGKDATGKDATGKDATGKNAEQNIKGKVQGFLEKILDPVKDKIASNGPIADELAKK LQEEEKVNNGEEENDKAVFLGEESKEDEEENEQAVNLEEKNAEEDKKVVNLEEKELEVKKETEED EDKEEIEKQKQEVEKAQERKQRQEEKKRKKQEQQEEKKRKRQEQRKERRAKNKIKKLADKIDEIS WNIDGIESQTSVKPKAVIDKITGPVYDYFTDDNKKAIYKTWGDLEDEEGEGLGKLLKELSDTRDEL RTKLNKDNKKYYAHENEPPLKENVDVSEIKEDLEKVKSGLEKVKEYLKDNSKFEEIKGYISYSQ f6-21.nt (SEQ ID NO:693) TAGGCAAAATTTAAATTTATAAAAACTTGTAAGGATGCTTGTATGAAAATATTGATAAAAAAGT TAAAAGTTGTATTATTTCTCAATTTAATTTTACTTATTTCTTGTGTTAATGAAAGTAATAGAAAC AAATTGGTTTTTAAGCTAAATATTGGAAGTGAGCCTGCTACTTTAGATGCTCAATTAATAAACG ATACGGTTGGATCAGGGATTGTAAGCCAAATGTTTCTTGGCATTTTAGATGGAGATCCCAGGAC TGGAGGATACAGACCGGGACTTGCTAAAAGTTGGGATATTTCTGATGACGGAGTAGTTTATACG TTTCATTTAAGAGATAATCTTGTTTGGAGTGATGGAGTTTCCATTACTGCCGAAGAATAA t6-21.nt (SEQ ID NO:694) TTGTGTTAATGAAAGTAATAGAAACAAATTGGTTTTTAAGCTAAATATTGGAAGTGAGCCTGCT ACTTTAGATGCTCAATTAATAAACGATACGGTTGGATCAGGGATTGTAAGCCAAATGTTTCTTG GCATTTTAGATGGAGATCCCAGGACTGGAGGATACAGACCGGGACTTGCTAAAAGTTGGGATA TTTCTGATGACGGAGTAGTTTATACGTTTCATTTAAGAGATAATCTTGTTTGGAGTGATGGAGT TTCCATTACTGCCGAAGAA f6-21.aa (SEQ ID NO:695) AKFKFIKTCKDACMKILIKKLKVVLFLNLILLISCVNESNRNKLVFKLNIGSEPATLDAQLINDTVGSG IVSQMFLGILDGDPRTGGYRPGLAKSWDISDDGVVYTFHLRDNLVWSDGVSITAEE t6-21.aa (SEQ ID NO:696) CVNESNRNKLVFKLNIGSEPATLDAQLINDTVGSGIVSQMFLGILDGDPRTGGYRPGLAKSWDISDD GVVYTFHLRDNLVWSDGVSITAEE f6-27.nt (SEQ ID NO:697) TAAAGAAAAGCTTGCATAAAAAGTATAACAAATTCTTTAATAATTAAAATCAAAAAGAATATA ATTATTGCACTAAAATTAAATTTATACAGTTATATAGAATCACTTAAGGAACAAAAAATGAAAT ACCTTAAAAACATTTCCTTATTTTTGTTAATTTTAGGTTGCAAATCCATCCCAAATGGTAATTTC AATCTACACGATACAAACCATAAATTAGGAAAACTAAAATTTCAAGAAGACTCGATAATAAGC AGAAATTATGATAATAAAATATCCATTGTGGGAGTATACAACCCTTTAACAGAAAAAGAAAATT TTAAAGTCAATATTTTCATCAAAAAAAAAGGATTACAAATAGATCCTGAAAATATTTTGATAAA TGAAGAAAAAATTAATTATTCAAAATATAAAGCAGAACTCAAAGTAAAATCTAGGTTTAATAAA AGCATTATCAGTATTTCACTAACTAATTCAAGAGATCTATTAACCTACATTTACGATAAAAGCA CAGGGAAATACATTAACATTGAGTTTAAGGACAATTGGAACGTATCGCACAGTATAAAATTTAA TAAGGAGTATATTTTAGCATATATAACAGATTTTGATAAAGAAATTAAAATATCTAAAAATATT TTGCAAAAACGTATTGATAATAGAAAAATTGAAATTGAAAAAACAGAGCTTAAAACAGAATAT AATGAAATAGAGGATTATTACATCTACAGTATGAAAATTCCAAAATTATTTGAAAAATCAGACG CTCCCTCTGAAACTTACGAAACATTTGTTATAGCAAATTATTACCCCTGTGAAAATTTAAATATA CTGTTTTTGAATTTAAGCTTATACTCTGATAAATTACGCTTTCTAAACTCTATTTATGATGAGAA TGATAGAAAATTAAAAATGGAGCCTCCTGTGAGAGCCTTAAAGAATTCAAAAACAATAAAAGA AACATTAAATATAGTATTAAGTCCTCAAAAAATAATAGAGCTAGCAAAAAACATTGAAAAAGA TATTACTCTAAAATTAAAATCTTACGGAGAAAAGGGAGAATTCACATTTGAAATATATAAACCA CTTCTTTTAAAATTCTTAAAAGAAGTAGATCATTGCATAAAAAATTTGCAATCAAGTAGGCATA AATTTTAA t6-27.nt (SEQ ID NO:698) TTGCAAATCCATCCCAAATGGTAATTTCAATCTACACGATACAAACCATAAATTAGGAA AACTAAAATTTCAAGAAGACTCGATAATAAGCAGAAATTATGATAATAAAATATCCATTGTGGG AGTATACAACCCTTTAACAGAAAAAGAAAATTTTAAAGTCAATATTTTCATCAAAAAAAAAGGA TTACAAATAGATCCTGAAAATATTTTGATAAATGAAGAAAAAATTAATTATTCAAAATATAAAG CAGAACTCAAAGTAAAATCTAGCTTTAATAAAAGCATTATCAGTATTTCACTAACTAATTCAAG AGATCTATTAACCTACATTTACGATAAAAGCACAGGGAAATACATTAACATTGACTTTAAGGAC AATTGGAACGTATCGCACAGTATAAAATTTAATAAGGAGTATATTTTAGCATATATAACAGATT TTGATAAAGAAATTAAAATATCTAAAAATATTTTGCAAAAACGTATTGATAATAGAAAAATTGA AATTGAAAAAACAGAGCTTAAAACAGAATATAATGAAATAGAGGATTATTACATCTACAGTAT GAAAATTCCAAAATTATTTGAAAAATCAGACGCTCCCTCTGAAACTTACGAAACATTTGTTATA GCAAATTATTACCCCTGTGAAAATTTAAATATACTGTTTTTGAATTTAAGCTTATACTCTGATAA ATTACGCTTTCTAAACTCTATTTATGATGAGAATGATAGAAAATTAAAAATGGAGCCTCCTGTG AGAGCCTTAAAGAATTCAAAAACAATAAAAGAAACATTAAATATAGTATTAAGTCCTCAAAAA ATAATAGAGCTAGCAAAAAACATTGAAAAAGATATTACTCTAAAATTAAAATCTTACGGAGAA AAGGGAGAATTCACATTTGAAATATATAAACCACTTCTTTTAAAATTCTTAAAAGAAGTAGATC ATTGCATAAAAAATTTGCAATCAAGTAGGCATAAATTT f6-27.aa (SEQ ID NO:699) RKACIKSITNSLIIKIKKNIIIALKLNLYSYIESLKEQKMKYLKNISLFLLILGCKSIPNGNFNLHDTNHK LGKLKFQEDSIISRNYDNKISIVGVYNPLTEKENFKVNIFIKKKGLQIDPENILINEEKINYSKYKAELK VKSSFNKSIISISLTNSRDLLTYIYDKSTGKYINIDFKDNWNVSHSIKFNKEYILAYITDFDKEIKISKNI LQKRIDNRKIEIEKTELKTEYNEIEDYYIYSMKIPKLFEKSDAPSETYETFVIANYYPCENLNILFLNLS LYSDKLRFLNSIYDENDPKLKMEPPVRALKNSKTIKETLNIVLSPQKIIELAKNIEKDITLKLKSYGEK GEFTFEIYKPLLLKFLKEVDHCIKNLQSSRHKF t6-27.aa (SEQ ID NO:700) CKSIPNGNFNLHDTNHKLGKLKFQEDSIISRNYDNKISIVGVYNPLTEKENFKVNIFIKKKGLQIDPEN ILINEEKINYSKYKAELKVKSSFNKSIISISLTNSRDLLTYIYDKSTGKYINIDFKDNWNVSHSIKFNKE YILAYITDFDKEIKISKNILQKRIDNRKIEIEKTELKTEYNEIEDYYIYSMKIPKLFEKSDAPSETYETFV IANYYPCENLNILFLNLSLYSDKLRFLNSIYDENDRKLKMEPPVRALKNSKTIKETLNIVLSPQKIIELA KNIEKDITLKLKSYGEKGEFTFEIYKPLLLKFLKEVDHCIKNLQSSRHKF f6-5.nt (SEQ ID NO:701) TAAATGAAGAAGTTTTTAATATCCGTTTATTTTTTATTGTTTTATGGTTGTTCAACTATATCTTTG GTAAAAATACCAGAAAAAGATAAAATAAATTTAACTGTTTTATCATCTTTAATGAATTATCCTG ATTTGAAGATTTCAAATTTTAAAATAAAAGACTACGAACATTTGCATTATTCATCTGATTTTGAA AGCTTGAGTGATACTAAAAATAGTGCTTATATTTACGTTGATGAATCTAGTTTCAATAATAATA TTAATTTTATTAAAGATCTTTTTATTTATAATAAGAAATTATATAGAATACTTATTGCTTATAGC TTGACCCAAGGTGCATCTTTTAAGGCAGAAGTTTTATCTTATCTTGAAAAACAAAAAATTATGA AAAATTTTTCATTGAAAATAAATTTTCCAACTGCTAAAAAATTTATGGATAATAAGTATTGGAT TGTAATTGCAAAAAACCATTTAGATTCTCTTGTTAAGAGTAAAAATTATTTAGTCTTGGCGAAT GTAAAGATGGAATATATACTCAAAAAGTTTTTAACTTGA t6-5.nt (SEQ ID NO:702) TTGTTCAACTATATCTTTGGTAAAAATACCAGAAAAAGATAAAATAAATTTAACTGTTTTATCA TCTTTAATGAATTATCCTGATTTGAAGATTTCAAATTTTAAAATAAAAGACTACGAACATTTGC ATTATTCATCTGATTTTGAAAGCTTGAGTGATACTAAAAATAGTGCTTATATTTACGTTGATGA ATCTAGTTTCAATAATAATATTAATTTTATTAAAGATCTTTTTATTTATAATAAGAAATTATATA GAATACTTATTGCTTATAGCTTGACCCAAGGTGCATCTTTTAAGGCAGAAGTTTTATCTTATCTT GAAAAACAAAAAATTATGAAAAATTTTTCATTGAAAATAAATTTTCCAACTGCTAAAAAATTTA TGGATAATAAGTATTGGATTGTAATTGCAAAAAACCATTTAGATTCTCTTGTTAAGAGTAAAAA T f6-5.aa (SEQ ID NO:703) MKKFLISVYFLLFYGCSTISLVKIPEKDKINLTVLSSLMNYPDLKISNFKIKDYEHLHYSSDFESLSDT KNSAYIYVDESSFNNNINFIKDLFIYNKKLYRILIAYSLTQGASFKAEVLSYLEKQKIMKNFSLKINFP TAKKFMDNKYWIVIAKNHLDSLVKSKNYLVLANVKMEYILKKFLT t6-5.aa (SEQ ID NO:704) CSTISLVKIPEKDKINLTVLSSLMNYPDLKISNFKIKDYEHLHYSSDFESLSDTKNSAYIYVDESSFNN NINFIKDLFIYNKKLYRILIAYSLTQGASFKAEVLSYLEKQKIMKNFSLKINFPTAKKFMDNKYWIVIA KNHLDSLVKSKN f7-30.nt (SEQ ID NO:705) TAGAGACGAAGTCACAAGCAAAATGTTAAAAGATTTACAAAATCAAGTTCAAGGGGGCAAATA ATGAAAAATTTAAAGACAAAAATTAATTTTTTAGGGATATTTTGGCTACTGTTACTATTTCTTTC TTGCGAATCAATACCATCACTTCCCCAAAAACCAACCCTAACAAACAAAGAAGATATTGAAAAT TTAATGCTCGATGAAGCAGAACTTTTTAGATACTCAACCGCACTAAATGTTTGGCTTTTGACTGT AAAATCTTATGTGATCAAATACTATCCTAATGACAAATTTCCTGTGTTTGAAAATTTTGATCCCG TGTTTGGCGATGAAAATGGAACTAAAGAAACAAATATACTAAAAAATCGAATTACCTACTACA ATCGATACATAGAAAAAACCGAACCGATTGTATTTGGGTGTTACAAAAAATACAGCAGAAGAT AA t7-30.nt (SEQ ID NO:706) TTGCGAATCAATACCATCACTTCCCCAAAAACCAACCCTAACAAACAAAGAAGATATTGAAAAT TTAATGCTCGATGAAGCAGAACTTTTTAGATACTCAACCGCACTAAATGTTTGGCTTTTGACTGT AAAATCTTATGTGATCAAATACTATCCTAATGACAAATTTCCTGTGTTTGAAAATTTTGATCCCG TGTTTGGCGATGAAAATGGAACTAAAGAAACAAATATACTAAAAAATCGAATTACCTACTACA ATCGATACATAGAAAAAACCGAACCGATTGTATTTGGGTGTTACAAAAAATACAGCAGAAGA f7-30.aa (SEQ ID NO:707) RRSHKQNVKRFTKSSSRGQIMKNLKTKINFLGIFWLLLLFLSCESIPSLPQKPTLTNKEDIENLMLDEA ELFRYSTALNVWLLTVKSYVIKYYPNDKFPVFENFDPVFGDENGTKETNILKNRITYYNRYIEKTEPI VFGCYKKYSRR t7-30.aa (SEQ ID NO:708) CESIPSLPQKPTLTNKEDIENLMLDEAELFRYSTALNVWLLTVKSYVIKYYPNDKFPVFENFDPVFGD ENGTKETNILKNRITYYNRYIEKTEPIVFGCYKKYSRR f76-1.nt (SEQ ID NO:709) TGAATATTAATAATAAAAAAAGGAGTAACAATGAAAATTATCAACATATTATTTTGTTTGTTTT TACTAATGCTAAACGGCTGTAATTCTAATGATACAAATACCAAGCAGACAAAAAGCAGACAAA AGCGTGATTAACCCAAAAAGAAGCAACACAAGAAAAACCTAAATCTAAATCTAAAGAAGACC TGCTTAGAGAAAAGCTATCTGATGATCAAAAAACACAACTTGACTGGTTAAAAACCGCTTTAAC TGGTGTTGGAAAATTTGATAAATTCTTAGAAAATGATGAAGGCAAAATTAAATCAGCACTTGAA CATATAAAGACTGAACTTGATAAATGTAATGGAAATGATGAAGGAAAAAACACCTTCAAAACT ACCGTTCAAGGGTTTTTTAGCGGCGGCAATATAGATAATTTTGCAGATCAAGCAACTGCTACCT GCAATTAA t76-1.nt (SEQ ID NO:710) CTGTAATTCTAATGATACAAATACCAAGCAGACAAAAAGCAGACAAAAGCGTGATTTAACCCA AAAAGAAGCAACACAAGAAAAACCTAAATCTAAATCTAAAGAAGACCTGCTTAGAGAAAAGCT ATCTGATGATCAAAAAACACAACTTGACTGGTTAAAAACCGCTTTAACTGGTGTTGGAAAATTT GATAAATTCTTAGAAAATGATGAAGGCAAAATTAAATCAGCACTTGAACATATAAAGACTGAA CTTGATAAATGTAATGGAAATGATGAAGGAAAAAACACCTTCAAAACTACCGTTCAAGGGTTTT TTAGCGGCGGCAATATAGATAATTTTGCAGATCAAGCAACTGCTACCTGCAAT f76-1.aa (SEQ ID NO:711) ILIIKKGVTMKIINILFCLFLLMLNGCNSNDTNTKQTKSRQKRDLTQKEATQEKPKSKSKEDLLREKL SDDQKTQLDWLKTALTGVGKFDKFLENDEGKIKSALEHIKTELDKCNGNDEGKNTFKTTVQGFFSG GNIDNFADQATATCN t76-1.aa (SEQ ID NO:712) CNSNDTNTKQTKSRQKRDLTQKEATQEKPKSKSKEDLLREKLSDDQKTQLDWLKTALTGVGKFDK FLENDEGKIKSALEHIKTELDKCNGNDEGKNTFKTTVQGFFSGGNIDNFADQATATCN f8-10.nt (SEQ ID NO:713) TAAGTAAGGAGAATATTTATGAAATATAATACGATTATAAGCATATTTGTTTGTTTGTTTTTAAC TGCTTGCAATCCAGATTTTAACACAAATAAGAAAAGAACTCTAAGTAAGGGGATAATTTCAAAT CAAGATGCAGATTCTGATAAAATAATAAAAAATAAATTACTTGATGATTTAATAAATTTAATAG AAAAAGCGAATGCAGATAGAGAAAAATATGTAAAAAAAATGGAAGAAGAACCTTCGGATCAAT ATGGAATGTTGGCTGTTTTTGGAGGTATGTATTGGGCAGAATCACCACGGGAATTAATATCTGA TACAGGTAGTGAGAGATCTATTAGGTATAGAAGGCGTGTTTATAGTATTTTATTAAATGCTATT GAAACTAATGAATTAAAGAAATTTTCAGAAATTAGAATACTGTCAATAAAAGTACTAGAAATAT TTAGCCTATTTAATCTATTTGGAAGTACTCTTGATGATGTGGTTGTTCACTTATATTCCAAAAAA GATACTCTAGGTAAACTAGATATTTCAAATTTAAAAAGACTTAAAAATTTGTTTGAAAAATTAT TATCTATAAAAACAATCGTTTCAAAGATGTCAAAACGTCTTTTATTGGATTATCAAAATAATGA AAATTTTATAAAAACAGATAACGCCAAGCTTGGATCTTATGTGGTTGCACTTTCCAATCAAATT CAAGAAAAATATAATGAAGCAGAAAGGCTGAAAAGCGAGATAATTTTAATATATACCCTTTAA t8-10.nt (SEQ ID NO:714) TTGCAATCCAGATTTTAACACAAATAAGAAAAGAACTCTAAGTAAGGGGATAATTTCAAATCAA GATGCAGATTCTGATAAAATAATAAAAAATAAATTACTTGATGATTTAATAAATTTAATAGAAA AAGCGAATGCAGATAGAGAAAAATATGTAAAAAAAATGGAAGAAGAACCTTCGGATCAATATG GAATGTTGGCTGTTTTTGGAGGTATGTATTGGGCAGAATCACCACGGGAATTAATATCTGATAC AGGTAGTGAGAGATCTATTAGGTATAGAAGGCGTGTTTATAGTATTTTATTAAATGCTATTGAA ACTAATGAATTAAAGAAATTTTCAGAAATTAGAATACTGTCAATAAAAGTACTAGAAATATTTA GCCTATTTAATCTATTTGGAAGTACTCTTGATGATGTGGTTGTTCACTTATATTCCAAAAAAGAT ACTCTAGGTAAACTAGATATTTCAAATTTAAAAAGACTTAAAAATTTGTTTGAAAAATTATTAT CTATAAAAACAATCGTTTCAAAGATGTCAAAACGTCTTTTATTGGATTATCAAAATAATGAAAA TTTTATAAAAACAGATAACGCCAAGCTTGGATCTTATGTGGTTGCACTTTCCAATCAAATTCAA GAAAAATATAATGAAGCAGAAAGGCTGAAA f8-10.aa (SEQ ID NO:715) VRRIFMKYNTIISIFVCLFLTACNPDFNTNKKRTLSKGIISNQDADSDKIIKNKLLDDLINLIEKANADR EKYVKKMEEEPSDQYGMLAVFGGMYWAESPRELISDTGSERSIRYRRRVYSILLNAIETNELKKFSE IRILSIKVLEIFSLFNLFGSTLDDVVVHLYSKKDTLGKLDISNLKRLKNLFEKLLSIKTIVSKMSKRLLL DYQNNENFIKTDNAKLGSYVVALSNQIQEKYNEAERLKSEIILIYTL t8-10.aa (SEQ ID NO:716) CNPDFNTNKKRTLSKGIISNQDADSDKIIKNKLLDDLINLIEKANADREKYVKKMEEEPSDQYGMLA VFGGMYWAESPRELISDTGSERSIRYRRRVYSILLNAIETNELKKFSEIRILSIKVLEIFSLFNLFGSTLD DVVVHLYSKKDTLGKLDISNLKRLKNLFEKLLSIKTIVSKMSKRLLLDYQNNENFIKTDNAKLGSYV VALSNQIQEKYNEAERLK f8-14.nt (SEQ ID NO:717) TAATATATATTCTTGATTAAGGGAAAGGAGAGTATTTTTATGAAAAAAAAAATGTTTTTATATA CATTGTTAACGATAGGATTGATGTCTTGTAATCTAAATTCTAAATTATCTGGTAATAAAGAGGA ACAAAAAAATAACAATGATATAAAAGAAGCTTTAAATGGCGTTCAAGAAAATGCTATTAATAA TTTATATGGAAATAAAAAAGAAAAAAAAGATTTTATTAAAAATTCGGAAAAATTGAAAGACAA GGGTTTAGACGTGACCACCCTCCCCTTAGAACCTGTAGTGGCGCCCTCCGTAGAATCTGCGGTG TCTTTAGGAGAATCTAATAATAGGATTGGTATACCAACCATTTCAATTGAGCATAATCAAAAAA AAGAGATAAAAGAAGAGGATTTTTTCCCTTCTACTGAGGAAGAAAAGCAAGCGGATAAAGCAA TTAAAGATATAGAGAATCTTATTGGAGAATCTGGATTTCCCGAGTTAATTGAGAATGTGTGCTC ACTTAAACATGAATATACTTTAATAAGAAGTGATTTTTATGATGTGATAACTAAGATTCAGAAT AAAAAAATATCACTAATGAAAAATTCTCATAATAATAGAAATAAAATAAGGGAACTAGTACAA TTGCAAAATAATTTAAAGATAGGAGACGAACTTGATAAAATTATGGGTTGCATTGATACTGCAG AACAAGAGATAAGATCTGCCGCTTTCTTTTTTGATGAAGCTAAGGAAAGCTTAAAAGAAGGTAT TATTAAAAGATTGGAAAAAAGTAAAAATAGGGCAGCATCACAATTATCTAAAAAGGCTTTAAA TAGAGCAGAGGATGCTTTAAGGTGCTTAGAAAATTATTCTTCTAAAAAAGGTGAGGCAATAGG AAGAAGAAGCTTTATAAAAGAAGTTGTTGAACAGGCAAAAAATGCTTTAAGTAAGTCTTAA t8-14.nt (SEQ ID NO:718) TTGTAATCTAAATTCTAAATTATCTGGTAATAAAGAGGAACAAAAAAATAACAATGATATAAAA GAAGCTTTAAATGGCGTTCAAGAAAATGCTATTAATAATTTATATGGAAATAAAAAAGAAAAA AAAGATTTTATTAAAAATTCGGAAAAATTGAAAGACAAGGGTTTAGACGTGACCACCCTCCCCT TAGAACCTGTAGTGGCGCCCTCCGTAGAATCTGCGGTGTCTTTAGGAGAATCTAATAATAGGAT TGGTATACCAACCATTTCAATTGAGCATAATCAAAAAAAAGAGATAAAAGAAGAGGATTTTTTC CCTTCTACTGAGGAAGAAAAGCAAGCGGATAAAGCAATTAAAGATATAGAGAATCTTATTGGA GAATCTGGATTTCCCGAGTTAATTGAGAATGTGTGCTCACTTAAACATGAATATACTTTAATAA GAAGTGATTTTTATGATGTGATAACTAAGATTCAGAATAAAAAAATATCACTAATGAAAAATTC TCATAATAATAGAAATAAAATAAGGGAACTAGTACAATTGCAAAATAATTTAAAGATAGGAGA CGAACTTGATAAAATTATGGGTTGCATTGATACTGCAGAACAAGAGATAAGATCTGCCGCTTTC TTTTTTGATGAAGCTAAGGAAAGCTTAAAAGAAGGTATTATTAAAAGATTGGAAAAAAGTAAA AATAGGGCAGCATCACAATTATCTAAAAAGGCTTTAAATAGAGCAGAGGATGCTTTAAGGTGC TTAGAAAATTATTCTTCTAAAAAAGGTGAGGCAATAGGAAGAAGAAGCTTTATAAAAGAAGTT GTTGAACAGGCAAAAAATGCTTTAAGTAAGTCT f8-14.aa (SEQ ID NO:719) YIFLIKGKESIFMKKKMFLYTLLTIGLMSCNLNSKLSGNKEEQKNNNDIKEALNGVQENAINNLYGN KKEKKDFIKNSEKLKDKGLDVTTLPLEPVVAPSVESAVSLGESNNRIGIPTISIEHNQKKEIKEEDFFP STEEEKQADKAIKDIENLIGESGFPELIENVCSLKHEYTLIRSDFYDVITKIQNKKISLMKNSHNNRNKI RELVQLQNNLKIGDELDKIMGCIDTAEQEIRSAAFFFDEAKESLKEGIIKRLEKSKNRAASQLSKKAL NRAEDALRCLENYSSKKGEAIGRRSFIKEVVEQAKNALSKS t8-14.aa (SEQ ID NO:720) CNLNSKLSGNKEEQKNNNDIKEALNGVQENAINNLYGNKKEKKDFIKNSEKLKDKGLDVTTLPLEP VVAPSVESAVSLGESNNRIGIPTISIEHNQKKEIKEEDFFPSTEEEKQADKAIKDIENLIGESGFPELIEN VCSLKHEYTLIRSDFYDVITKIQNKKISLMKNSHNNRNKIRELVQLQNNLKIGDELDKIMGCIDTAEQ EIRSAAFFFDEAKESLKEGIIKRLEKSKNRAASQLSKKALNRAEDALRCLENYSSKKGEAIGRRSFIKE VVEQAKNALSKS f01A.nt BB001 (SEQ ID NO:721) TGATTAATTTTTTTTAAGGATTACGTTTTGAAAAGAAACAAAATTTGGAAAACGTTAAA ACTGTTTCAAATAACTTTACTGTTCTCATGCTCTTTTTATTCTAAATCAAACAACACAGAAGCGA TAAGTGAATTACAATCAAGCCCTATTAAACTTGGAAAAATTAAAGTTTTACAAAAAACAGAAAA GATTGTAAGCACCCAAAATCTTCAAAACTTACAACAAAGCCAGTTCTTTAAAAATGAAAAAGAA AAAATAATTAAAAAAATTGCACAAGAATTTGATGAGAATGAAAAATTGATTAATAAAATAGGT CCAAATATCGAAATGTTTGCTCAAACAATAAACACGGATATTCAAAAAATCGAACCTAATGATC AATTTGGAATAAATAAAACTTTATTCACAGAAAAAAAAGACAATAATATTGACTTTATGTTAAA AGACAATCGACTTAGAAGATTATTTTACTCATCTTTAAATTATGATGAAAATAAAATCAAAAAA TTAGCCACAATACTCGCGCAAACATCAAGCTCAAACGACTACCATTACACACTTATTGGTTTAA TTTTTTGGACAGGATTTAAAATCCAAGAAGCATTTGAAAGCGCTGTTAATATTTTAACTAAAGA CGAGCAAAAGCGCCTAATTTTTAATTTTAGAACAAAAACAGTAAAAGAGATTCAGGAAAATTTT GAAAAACTAATGCAAGAGAGAAATTCATGGATAAAAATCGTCGATAACATTATTGGCGAATAT GACAAAAATACGGGAGGATGCAAAGCTGATGGAAAAATTCTCGGAGAAGTAATAAGGGTTGGA TACGAGCATGAACTCGACTCAAATAAAAGTATGCAAATTTTAAACAATATTGAAACACCGCTAA AAACCTGTTGTGACCACATACACTACTAA t01A.nt BB001 (SEQ ID NO:722) TGCTCTTTTTATTCTAAATCAAACAACACAGAAGCGATAAGTGAATTACAATCAAGCCC TATTAAACTTGGAAAAATTAAAGTTTTACAAAAAACAGAAAAGATTGTAAGCACCCAAAATCTT CAAAACTTACAACAAAGCCAGTTCTTTAAAAATGAAAAAGAAAAAATAATTAAAAAAATTGCA CAAGAATTTGATGAGAATGAAAAATTGATTAATAAAATAGGTCCAAATATCGAAATGTTTGCTC AAACAATAAACACGGATATTCAAAAAATCGAACCTAATGATCAATTTGGAATAAATAAAACTTT ATTCACAGAAAAAAAAGACAATAATATTGACTTTATGTTAAAAGACAATCGACTTAGAAGATTA TTTTACTCATCTTTAAATTATGATGAAAATAAAATCAAAAAATTAGCCACAATACTCGCGCAAA CATCAAGCTCAAACGACTACCATTACACACTTATTGGTTTAATTTTTTGGACAGGATTTAAAATC CAAGAAGCATTTGAAAGCGCTGTTAATATTTTAACTAAAGACGAGCAAAAGCGCCTAATTTTTA ATTTTAGAACAAAAACAGTAAAAGAGATTCAGGAAAATTTTGAAAAACTAATGCAAGAGAGAA ATTCATGGATAAAAATCGTCGATAACATTATTGGCGAATATGACAAAAATACGGGAGGATGCA AAGCTGATGGAAAAATTCTCGGAGAAGTAATAAGGGTTGGATACGAGCATGAACTCGACTCAA ATAAAAGTATGCAAATTTTAAACAATATTGAAACACCGCTAAAAACCTGTTGTGACCACATACA CTAC f01A.aa BB001 (SEQ ID NO:723) LIFFKDYVLKRNKIWKTLKLFQITLLFSCSFYSKSNNTEAISELQSSPIKLGKIKVLQKTEKIVSTQNLQ NLQQSQFFKNEKEKIIKKIAQEFDENEKLINKIGPNIEMFAQTINTDIQKIEPNDQFGINKTLFTEKKDN NIDFMLKDNRLRRLFYSSLNYDENKIKKLATILAQTSSSNDYHYTLIGLIFWTGFKIQEAFESAVNILT KDEQKRLIFNFRTKTVKEIQENFEKLMQERNSWIKIVDNIIGEYDKNTGGCKADGKILGEVIRVGYE HELDSNKSMQILNNIETPLKTCCDHIHY t01A.aa BB001 (SEQ ID NO:724) CSFYSKSNNTEAISELQSSPIKLGKIKVLQKTEKIVSTQNLQNLQQSQFFNKNEKEKIIKKIAQEFDENE KLINKIGPNIEMFAQTINTDIQKIEPNDQFGINKTLFTEKKDNNIDFMLKDNRLRRLFYSSLNYDENKI KKLATILAQTSSSNDYHYTLIGLIFWTGFKIQEAFESAVNILTKDEQKRLIFNFRTKTVKEIQENFEKL MQERNSWIKIVDNIIGEYDKNTGGCKADGKILGEVIRVGYEHELDSNKSMQILNNIETPLKTCCDHI HY f02A.nt BB002 (SEQ ID NO:725) TAATTAATACTGGTTTTAATTTATAAGGAGAGTATTTTGAAAAAAGCCAAACTAAATATAATCA AGATTAATATTATTACAATGATATTAACTTTAATTTGCATCTCATGTGCACCTTTTAACAAAATC AATCCCAAGGCAAATGAAAACACCAAGCTTAAAAAAAACACCAGACTGAAAAAACCCGCCAAT CCAGGGGAAAACATCCAAAATTTTAAAGATAAATCTGGAGACCTTGGCGCTTCTGATGAAAAA TTTATGGGAACTACCGCTTCAGAGCTAAAAGCAATTGGTAAGGAGCTAGAAGATCGAAAAAAT CAATACGATATACAAATAGCCAAAATTACTAATGAAGAATCTAACCTATTAGATACTTATATTC GGGCTTATGAACTAGCTAACGAAAATGAAAAAATGCTTTTAAAAAGATTTCTTCTTTCATCTTT AGATTATAAAAAAGAAAACATAGAGACATTAAAAGAAATTCTTGAAAAACTCATAAATAATTA CGAAAACGACCCCAAAATTGCTGCAAATTTCCTTTATCGCATAGCGCTGGATATTCAATTAAAA CTGGAAAAGCACTTAAAATCAATAAATGAAAAACTGGACACTCTAAGCAAAGAAAATTCAAAA GAAGATTTAGAGGCGTTGCTAGAACAAGTAAAATCTGCCTTACAGCTACAAGAAAAGTTTAAA AAAACCCTAAACAAAACTCTTGAAGATTACCGTAAAAATACTAACAACATTCAAGAAAATAAA GTACTAGCAGAACACTTTAATAAATATTACAAAGACTCTGATTCTTTACAATCTGCCTTTTATTA A t02A.nt BB002 (SEQ ID NO:726) TGTGCACCTTTTAACAAAATCAATCCCAAGGCAAATGAAAACACCAAGCTTAAAAAAAACACC AGACTGAAAAAACCCGCCAATCCAGGGGAAAACATCCAAAATTTTAAAGATAAATCTGGAGAC CTTGGCGCTTCTGATGAAAAATTTATGGGAACTACCGCTTCAGAGCTAAAAGCAATTGGTAAGG AGCTAGAAGATCGAAAAAATCAATACGATATACAAATAGCCAAAATTACTAATGAAGAATCTA ACCTATTAGATACTTATATTCGGGCTTATGAACTAGCTAACGAAAATGAAAAAATGCTTTTAAA AAGATTTCTTCTTTCATCTTTAGATTATAAAAAAGAAAACATAGAGACATTAAAAGAAATTCTT GAAAAACTCATAAATAATTACGAAAACGACCCCAAAATTGCTGCAAATTTCCTTTATCGCATAG CGCTGGATATTCAATTAAAACTGGAAAAGCACTTAAAATCAATAAATGAAAAACTGGACACTCT AAGCAAAGAAAATTCAAAAGAAGATTTAGAGGCGTTGCTAGAACAAGTAAAATCTGCCTTACA GCTACAAGAAAAGTTTAAAAAAACCCTAAACAAAACTCTTGAAGATTACCGTAAAAATACTAA CAACATTCAAGAAAATAAAGTACTAGCAGAACACTTTAATAAATATTACAAAGACTCTGATTCT TTACAATCTGCCTTTTAT f02A.aa BB002 (SEQ ID NO:727) LILVLIYKESILKKAKLNIIKINIITMILTLICISCAPFNKINPKANENTKLKKNTRLKKPANPGENIQNF KDKSGDLGASDEKFMGTTASELKAIGKELEDRKNQYDIQIAKITNEESNLLDTYIRAYELANENEKM LLKRFLLSSLDYKKENIETLKEILEKLINNYENDPKIAANFLYRIALDIQLKLEKHLKSINEKLDTLSKE NSKEDLEALLEQVKSALQLQEKFKKTLNKTLEDYRKNTNNIQENKVLAEHFNKYYKDSDSLQSAFY t02A.aa BB002 (SEQ ID NO:728) CAPFNKINPKANENTKLKKNTRLKKPANPGENIQNFKDKSGDLGASDEKFMGTTASELKAIGKELE DRKNQYDIQIAKITNEESNLLDTYIRAYELANENEKMLLKRFLLSSLDYKKENIETLKEILEKLTNNYE NDPKIAANFLYRIALDIQLKLEKHLKSINEKLDTLSKENSKEDLEALLEQVKSALQLQEKFKKTLNKT LEDYRKNTNNIQENKVLAEHFNKYYKDSDSLQSAFY f03A.nt BB006 (SEQ ID NO:729) TGATTTAATGTAAATTTTAATTACCGCCTAAAAAAGGCTTTAAATGGTATAAAGGAAGAAGATC TAATGGTATTTAGAACATATAAACATTTGGAACTAATAATGCTGCCCATGTTAATGCTGAGTTG CGCTTTTTTTAAGAAACCACAATCTGTACATCAAGACAGCAATACTGGCAAACCAATAAGCGAT GAAAAATTACATTTAATATCAGGCAAAATTTCAAATAAAAAATTGCCAATCATAAATAGTAATC ATGACGTAACTTGGATAAAAACAAAGGCAATGACAATCTTAGGCGAAGATGGAAAAGAAATAC CAGAATTTAAAAACAAATTTGGATATTCTTATATAATATCTCCTGTAAAAATGGATGGAAAATA TAGTTATTACGCGTCATTATTAATACTTTTTGAAACAACTAAAAATGGAGATGATGAATATGAA ATTGAAGATGTTAAATTTGTAACAGCTGGTTCCACCCTAGAACTTAAAAATTCTCTTTTAGCTGT TGAAAATTCACAAGAAGAAGGATATGTTACTGCATACCCATTTGGAATATTGATGAGTGACGA GATTAAAAATGCTTTTAAATTAACATATAAAAATGGTCATTGGAATTATATGCTTGCAGATTTA ACTGTCAAAAATAAACTTACTCAAGAAACTAAAATTTATAAAATTTCTCTTAATTCAAAATTAA TTATTGAATTTTTAAAAGAAGTGCTAAAAGAAAATTCTATATTAAAAGACATAGCTGGAGATTT ATTTGAAGATATATAA t03A.nt BB006 (SEQ ID NO:730) TGCGCTTTTTTTAAGAAACCACAATCTGTACATCAAGACAGCAATACTGGCAAACCAATAAGCG ATGAAAAATTACATTTAATATCAGGCAAAATTTCAAATAAAAAATTGCCAATCATAAATAGTAA TCATGACGTAACTTGGATAAAAACAAAGGCAATGACAATCTTAGGCGAAGATGGAAAAGAAAT ACCAGAATTTAAAAACAAATTTGGATATTCTTATATAATATCTCCTGTAAAAATGGATGGAAAA TATAGTTATTACGCGTCATTATTAATACTTTTTGAAACAACTAAAAATGGAGATGATGAATATG AAATTGAAGATGTTAAATTTGTAACAGCTGGTTCCACCCTAGAACTTAAAAATTCTCTTTTAGCT GTTGAAAATTCACAAGAAGAAGGATATGTTACTGCATACCCATTTGGAATATTGATGAGTGACG AGATTAAAAATGCTTTTAAATTAACATATAAAAATGGTCATTGGAATTATATGCTTGCAGATTT AACTGTCAAAAATAAACTTACTCAAGAAACTAAAATTTATAAAATTTCTCTTAATTCAAAATTA ATTATTGAATTTTTAAAAGAAGTGCTAAAAGAAAATTCTATATTAAAAGACATAGCTGGAGATT TATTTGAAGATATA f03A.aa BB006 (SEQ ID NO:731) FNVNFNNNLKKALNGIKEEDLMVFRTYKHLELIMLPMLMLSCAFFKKPQSVHQDSNTGKPISDEKL HLISGKISNKKLPIINSNHDVTWIKTKAMTILGEDGKEIPEFKNKFGYSYIISPVKMDGKYSYYASLLI LFETTKNGDDEYEIEDVKFVTAGSTLELKNSLLAVENSQEEGYVTAYPFGILMSDEIKNAFKLTYKN GHWNYMLADLTVKNKLTQETKIYKISLNSKLIIEFLKEVLKENSILKDIAGDLFEDI t03A.aa BB006 (SEQ ID NO:732) CAFFKKPQSVHQDSNTGKPISDEKLHLISGKISNKKLPIINSNHDVTWIKTKAMTILGEDGKEIPEFKN KFGYSYIISPVKMDGKYSYYASLLILFETTKNGDDEYEIEDVKFVTAGSTLELKNSLLAVENSQEEGY VTAYPFGILMSDEIKNAFKLTYKNGHWNYMLADLTVKNKLTQETKIYKISLNSKLIIEFLKEVLKEN SILKDIAGDLFEDI f04A.nt BB011 (SEQ ID NO:733) TAATTACCAAAGATAAGTAAACTTGCAAATAAAACTACACGTATTGAAAGTAGATTTGAAATTT CCATTATATTTATATATAATGGCACTAAATATCTGAAAATGAAGGAGAAGCGGGTGGGCAATA AAATTTTTTATATTTCAGTGGTTTTAATTTTAATAGTTGGTTGCGACTGGGGAACTATTAAAGAT AAAAGTACAGAAATTTCCAAGCTATTAAGAACGGACAAAGATAAGACTAAAAATCAAGATAGA ATAGAATTGGGTGAAGATAATTTTGTATCTAAAAATAATATGTCTACTACTGATACGGGCATTA CTAGTTTAGGAAGTCTAAACAACTTGGATTTAATTAATCGTTCACAGCGGGTCAGTGAACCACC TATAATCTCAAATGAGAAAGCCATAGCTACTCAAGCAAAAGTAGATTTAATGAACAACATTAAT GTTACTATAATAAACCCAAAACCAGCTCAAAATTTGGGAAATTCTTTAAACAATACTACTACTG AAGATAGTGTGAAGTTTTTATCAATTGAAAACCAAGAGTGGCTTATTAGTAAAAAGATTTTGCC CAGTAAGTTGGAAAATTTAGAAAGCTTTCTAAAAACACAACACGAAAAAGAAGCTTTTAAGAC GGCTAAAACTATACAAAGTCTCATTAGTAATTCCAATATGGGTAAAGAAATTATTAAGTTTAAG GAAGAATATTACAAACTTTATAATTTGTTTGAAGGCATACAACAAAAATTCCATAGTCAAAGGA ATTCATTTATAAAAGATACTAAATTTGGGGAAAATAGACAAAAAAATGCAGTTATATTTAAATC CTTTTCATCTATAGAGAAAGAAATTAGAGATTTGAATTATAAGTTGNGTGAAATCCAAAGTAAT TTTCAAATTGCAGATGTTAGCTGGAATAATGCAAACTCTCTTTTAAAAGAATCTATAGAAAAAT TAATTCAGGCAATTGAAAAAAGGTATGACAATGAGAGTAGAAAGCAAGGTCAAATTGGTGGAC CTGCTAATAGATGGGATAAAAATCAAGCTGACAATTTTGCTAAGGATGCAAAGTATAAGGCAG AACATTCAGCAAATGATTTGGAAAATGCAGCCAACTATTTTAGATATAGTTGTTCAAATGAAAA AGAAGCTAAAAAGCTATTAGAAGAAATTAAAAAAAGATTTGTACGAATTGGTATTAGCCTATA A t04A.nt BB011 (SEQ ID NO:734) TGCGACTGGGGAACTATTAAAGATAAAAGTACAGAAATTTCCAAGCTATTAAGAACGGACAAA GATAAGACTAAAAATCAAGATAGAATAGAATTGGGTGAAGATAATTTTGTATCTAAAAATAAT ATGTCTACTACTGATACGGGCATTACTAGTTTAGGAAGTCTAAACAACTTGGATTTAATTAATC GTTCACAGCGGGTCAGTGAACCACCTATAATCTCAAATGAGAAAGCCATAGCTACTCAAGCAA AAGTAGATTTAATGAACAACATTAATGTTACTATAATAAACCCAAAACCAGCTCAAAATTTGGG AAATTCTTTAAACAATACTACTACTGAAGATAGTGTGAAGTTTTTATCAATTGAAAACCAAGAG TGGCTTATTAGTAAAAAGATTTTGCCCAGTAAGTTGGAAAATTTAGAAAGCTTTCTAAAAACAC AACACGAAAAAGAAGCTTTTAAGACGGCTAAAACTATACAAAGTCTCATTAGTAATTCCAATAT GGGTAAAGAAATTATTAAGTTTAAGGAAGAATATTACAAACTTTATAATTTGTTTGAAGGCATA CAACAAAAATTCCATAGTCAAAGGAATTCATTTATAAAAGATACTAAATTTGGGGAAAATAGA CAAAAAAATGCAGTTATATTTAAATCCTTTTCATCTATAGAGAAAGAAATTAGAGATTTGAATT ATAAGTTGNGTGAAATCCAAAGTAATTTTCAAATTGCAGATGTTAGCTGGAATAATGCAAACTC TCTTTTAAAAGAATCTATAGAAAAATTAATTCAGGCAATTGAAAAAAGGTATGACAATGAGAG TAGAAAGCAAGGTCAAATTGGTGGACCTGCTAATAGATGGGATAAAAATCAAGCTGACAATTT TGCTAAGGATGCAAAGTATAAGGCAGAACATTCAGCAAATGATTTGGAAAATGCAGCCAACTA TTTTAGATATAGTTGTTCAAATGAAAAAGAAGCTAAAAAGCTATTAGAAGAAATTAAAAAAAG ATTTGTACGAATTGGTATTAGCCTA f04A.aa BB011 (SEQ ID NO:735) LPKISKLANKTTRIESRFEISIIFIYNGTKYLKMKEKRVGNKIFYISVVLILIVGCDWGTIKDKS TEISKLLRTDKDKTKNQDRIELGEDNFVSKNNMSTTDTGITSLGSLNNLDLINRSQRVSEPPIISNEKA IATQAKVDLMNNINVTIINPKPAQNLGNSLNNTTTEDSVKFLSIENQEWLISKKILPSKLENLESFLKT QHEKEAFKTAKTIQSLISNSNMGKEIIKFKEEYYKLYNLFEGIQQKFHSQRNSFIKDTKFGENRQKNA VIFKSFSSIEKEIRDLNYKLXEIQSNFQIADVSWNNANSLLKESIEKLIQAIEKRYDNESRKQGQIGGPA NRWDKNQADNFAKDAKYKAEHSANDLENAANYFRYSCSNEKEAKKLLEEIKKRFVRIGISL t04A.aa BB011 (SEQ ID NO:736) CDWGTIKDKSTEISKLLRTDKDKTKNQDRIELGEDNFVSKNNMSTTDTGITSLGSLNNLDLINRSQR VSEPPIISNEKAIATQAKVDLMNNINVTIINPKPAQNLGNSLNNTTTEDSVKFLSIENQEWLISKKILPS KLENLESFLKTQHEKEAFKTAKTIQSLISNSNMGKEIIKFKEEYYKLYNLFEGIQQKFHSQRNSFIKDT KFGENRQKNAVIFKSFSSIEKEIRDLNYKLXEIQSNFQIADVSWNNANSLLKESIEKLIQAIEKRYDNE SRKQGQIGGPANRWDKNQADNFAKDAKYKAEHSANDLENAANYFRYSCSNEKEAKKLLEEIKKRF VRIGISL f05A.nt BB009 (SEQ ID NO:737) TAAATAAATTGTAGGATAAAAATGAAACAAAAATACGAAAACTATTTTAAAAAAAGATTAATT TTAAACCTATTAATATTTTTACTACTAGCATGCTCAAGCGAATCCATATTTTCACAATTAGGAAA TCTGCAAAAAATAAAACATGAATACAATATTTTGGGCAGTTCAAGTCCAAGAGGAATTTCTCTA GTAGGAGAAACTCTCTACATTGCAGCCATGCATTTATTTAAAAAAGAAAACGGCAAGATTGAA AAAATTGATTTGAGCAATTCTTATGAGTTTATAAACGACATTGTAAATATATCTGGAAAAACCT ATCTTTTAGCGCAAAACAAAGAAGAAGAATTAGAAGTTTGCGAGCTAAATGGAAAAGATTGGA CATTAAAATTTAAAAAACCGCTAAAAGCATATAAATTCTTAAAATCCGTAGAAGAGATGGCGTA A t05A.nt BB009 (SEQ ID NO:738) TGCTCAAGCGAATCCATATTTTCACAATTAGGAAATCTGCAAAAAATAAAACATGAATACAATA TTTTGGGCAGTTCAAGTCCAAGAGGAATTTCTCTAGTAGGAGAAACTCTCTACATTGCAGCCAT GCATTTATTTAAAAAAGAAAACGGCAAGATTGAAAAAATTGATTTGAGCAATTCTTATGAGTTT ATAAACGACATTGTAAATATATCTGGAAAAACCTATCTTTTAGCGCAAAACAAAGAAGAAGAA TTAGAAGTTTGCGAGCTAAATGGAAAAGATTGGACATTAAAATTTAAAAAACCGCTAAAAGCA TATAAATTCTTAAAATCCGTAGAAGAGATGGCG f05A.aa BB009 (SEQ ID NO:739) INCRIKMKQKYENYFKKRLILNLLIFLLLACSSESIFSQLGNLQKIKHEYNILGSSSPRGISLVGETLYIA AMHLFKKENGKIEKIDLSNSYEFINDIVNISGKTYLLAQNKEEELEVCELNGKDWTLKFKKPLKAYK FLKSVEEMA t05A.aa BB009 (SEQ ID NO:740) CSSESIFSQLGNLQKIKHEYNILGSSSPRGISLVGETLYIAAMHLFKKENGKIEKIDLSNSYEFINDIVNI SGKTYLLAQNKEEELEVCELNGKDWTLKFKKPLKAYKFLKSVEEMA f06A.nt BB014 (SEQ ID NO:741) TAAGGAGCATATATGAGGATTTTGGTTGGCGTTTGTATAATAGCATTGGCTTTATTGGGTTGTT ATTTGCCTGATAATCAGGAACAAGCTGTTCAAACTTTTTTTGAGAATTCGGAAAGTAGTGATAT GGGTTCCGATGAGATTGTTACTGAAGGCATATTTTCTAGTTTAAAATTATATGCGTCTGAACAT CCTTTATTGGTTGAGATAAAAAAGACTTTAATTAGTTTAAAAGATCCTAATTATCNNGNTGTAG TACNCCCAGTGAGTGACTATAATGAGGAGTATTTTAATAAATTCTTTCTAGATTTAGGGTCTGA GCAATCTAAAGACCTGATTAAGTTGTTTATTATGGTAAAAAATGAGCAGAACAATAATAAATTT ATGCGTATAGTTCGTTGGCTGTATTCATGTATAGAGGAGTTATATTCTCTAGATATTAAGTATTC TGGCGAGGGGAGCCATGAGTATAATCGTAATATGCCTAGACCCACTGCTTATGAACAATATTTA AAAGTGAAGAGGTATGATTATAATAGCCCAGTTTCTATTTTACCTACATAA t06A.nt BB014 (SEQ ID NO:742) TGTTATTTGCCTGATAATCAGGAACAAGCTGTTCAAACTTTTTTTGAGAATTCGGAAAGTAGTG ATATGGGTTCCGATGAGATTGTTACTGAAGGCATATTTTCTAGTTTAAAATTATATGCGTCTGA ACATCGTTTATTGGTTGAGATAAAAAAGACTTTAATTAGTTTAAAAGATCCTAATTATCNNGNT GTAGTACNCCCAGTGAGTGACTATAATGAGGAGTATTTTAATAAATTCTTTCTAGATTTAGGGT CTGAGCAATCTAAAGACCTGATTAAGTTGTTTATTATGGTAAAAAATGAGCAGAACAATAATAA ATTTATGCGTATAGTTCGTTGGCTGTATTCATGTATAGAGGAGTTATATTCTCTAGATATTAAGT ATTCTGGCGAGGGGAGCCATGAGTATAATCGTAATATGCCTAGACCCACTGCTTATGAACAATA TTTAAAAGTGAAGAGGTATGATTATAAT f06A.aa BB014 (SEQ ID NO:743) GAYMRILVGVCIIALALLGCYLPDNQEQAVQTFFENSESSDMGSDEIVTEGIFSSLKLYASEHRLLVEI KKTLISLKDPNYXXVVXPVSDYNEEYFNKFFLDLGSEQSKDLIKLFIMVKNEQNNNKFMRIVRWLY SCIEELYSLDIKYSGEGSHEYNRNMPRPTAYEQYLKVKRYDYNSPVSILPT t06A.aa BB014 (SEQ ID NO:744) CYLPDNQEQAVQTFFENSESSDMGSDEIVTEGIFSSLKLYASEHRLLVEIKKTLISLKDPNYXXVVXP VSDYNEEYFNKFFLDLGSEQSKDLIKLFIMVKNEQNNNKFMRIVRWLYSCIEELYSLDIKYSGEGSH EYNRNMPRPTAYEQYLKVKRYDYN f07A.nt BB023 (SEQ ID NO:745) TAAAGTATTTTATTTTTTTTATTATCCACTGTTCTTTTTGCTCAAGAGACTGATGGATTA GCAGAGGGTTCTAAAAGGGCAGAGCCTGGAGAATTAGTTTTAGATTTTGCCGAGCTTGCAAGA GATCCAAGTTCAACTAGACTTGATCTTACAAATTATGTTGATTATGTATATTCGGGCGCTTCTGG TATTGTTAAGCCGGAAGATATGGTTGTAGATCTTGGGATAAATAATTGGAGCGTTTTACTTACT CCTTCTGCAAGGTTGCAGGCTTACGTTAAAAATTCAGTTGTTGCGCCCGCTGTTGTTAAGAGTG AGTCAAAAAGGTACGCAGGTGATACTATTTTAGGGGTAAGAGTTTTGTTTCCAAGCTATTCTCA ATCATCTGCTATGATTATGCCACCATTTAAAATTCCTTTTTATTCAGGGGAAAGTGGCAATCAAT TTTTAGGCAAAGGTCTTATTGATAACATTAAAACCATGAAAGAAATTAAGGTATCTGTTTATAG TTTAGGGTATGAGATAGATCTTGAGGTTTTATTTGAAGATATGAATGNCATGGAATATGCTTNN TCTATGGGTACTTTAAAGTTTAAAGGGTGGGCTGATTTAATTTGGTCAAATCCTAACTATATTCC TAATATATCATCCAGAATTATTAAAGACGATGTTCCAAATTATCCTCTTGCTTCAAGTAAAATG AGATTTAAGGCTTTTAGAGTTTCAAAGTCACACAGTTCAAAAGAGCAAAATTTCATCTTTTATG TTAAAGATTTAAGAGTTCTTTATGATAAGTTGAGTGTTTCAATAGATTCTGATATTGACAGTGA GTCTGTATTTAAAGTTTATGAGACTAGCGGAACTGAATCCCTTCGTAAATTAAAGGCACACGNA ACNTTTAAAAGNGTTTTAAAGCTTAGAGAAAAAATTTCTATGCCTGAAGGCTCTTTCCAAAACT TTGTAGAAAAGATTGAGAGTGAAAAACCTGAAGAATCATCTCCGAAAAATTAG t07A.nt BB023 (SEQ ID NO:746) GAGGGTTCTAAAAGGGCAGAGCCTGGAGAATTAGTTTTAGATTTTGCCGAGCTTGCAAGAGAT CCAAGTTCAACTAGACTTGATCTTACAAATTATGTTGATTATGTATATTCGGGCGCTTCTGGTAT TGTTAAGCCGGAAGATATGGTTGTAGATCTTGGGATAAATAATTGGAGCGTTTTACTTACTCCT TCTGCAAGGTTGCAGGCTTACGTTAAAAATTCAGTTGTTGCGCCCGCTGTTGTTAAGAGTGAGT CAAAAAGGTACGCAGGTGATACTATTTTAGGGGTAAGAGTTTTGTTTCCAAGCTATTCTCAATC ATCTGCTATGATTATGCCACCATTTAAAATTCCTTTTTATTCAGGGGAAAGTGGCAATCAATTTT TAGGCAAAGGTCTTATTGATAACATTAAAACCATGAAAGAAATTAAGGTATCTGTTTATAGTTT AGGGTATGAGATAGATCTTGAGGTTTTATTTGAAGATATGAATGNCATGGAATATGCTTNNTCT ATGGGTACTTTAAAGTTTAAAGGGTGGGCTGATTTAATTTGGTCAAATCCTAACTATATTCCTA ATATATCATCCAGAATTATTAAAGACGATGTTCCAAATTATCCTCTTGCTTCAAGTAAAATGAG ATTTAAGGCTTTTAGAGTTTCAAAGTCACACAGTTCAAAAGAGCAAAATTTCATCTTTTATGTT AAAGATTTAAGAGTTCTTTATGATAAGTTGAGTGTTTCAATAGATTCTGATATTGACAGTGAGT CTGTATTTAAAGTTTATGAGACTAGCGGAACTGAATCCCTTCGTAAATTAAAGGCACACGNAAC NTTTAAAAGNGTTTTAAAGCTTAGAGAAAAAATTTCTATGCCTGAAGGCTCTTTCCAAAACTTT GTAGAAAAGATTGAGAGTGAAAAACCTGAAGAATCATCTCCGAAAAAT f07A.aa BB023 (SEQ ID NO:747) SILFFLLSTVLFAQETDGLAEGSKRAEPGELVLDFAELARDPSSTRLDLTNYVDYVYSGASGIVKPED MVVDLGINNWSVLLTPSARLQAYVKNSVVAPAVVKSESKRYAGDTILGVRVLFPSYSQSSAMIMPP FKIPFYSGESGNQFLGKGLIDNIKTMKEIKVSVYSLGYEIDLEVLFEDMNXMEYAXSMGTLKFKGW ADLIWSNPNYIPNISSRIIKDDVPNYPLASSKMRFKAFRVSKSHSSKEQNFIFYVKDLRVLYDKLSVSI DSDIDSESVFKVYETSGTESLRKLKAHXTFKXVLKLREKISMPEGSFQNFVEKIESEKPEESSPKN t07A.aa BB023 (SEQ ID NO:748) EGSKRAEPGELVLDFAELARDPSSTRLDLTNYVDYVYSGASGIVKPEDMVVDLGINNWSVLLTPSA RLQAYVKNSVVAPAVVKSESKRYAGDTILGVRVLFPSYSQSSAMIMPPFKIPFYSGESGNQFLGKGLI DNIKTMKEIKVSVYSLGYEIDLEVLFEDMNXMEYAXSMGTLKFKGWADLIWSNPNYIPNISSRIIKD DVPNYPLASSKMRFKAFRVSKSHSSKEQNFIFYVKDLRVLYDKLSVSIDSDIDSESVFKVYETSGTES LRKLKAHXTFKXVLKLREKISMPEGSFQNFVEKIESEKPEESSPKN f08A.nt BB024 (SEQ ID NO:749) TGAATATTAATAATAAAAAAAGGAGTAACAATGAAAATCATCAACATATTATTTTGTTTATTTT TACTAATGCTAAACGGCTGTAATTCTAATGATAATGACACTTTAAAAAACAATGCCCAACAAAC AAAAAGACGGGGAAAGCGTGATTTAACCCAAAAAGAAACAACACAAGAAAAACCAAAATCTA AAGAAGAACTACTTAGAGAAAAGCTATCTGACGATCAAAAAACACATCTTGACTGGTTAAAAC CCGCTTTAACTGGTGCTGGAGAATTTGACAAATTCTTAGAAAATGATGATGATAAAATAAAATC AGCACTTGATCATATAAAAACTCAACTTGATAGTTGTAATGGTGATCAAGCAGAACAACAAAA AACCACTTTCAAAACTGTGGTTACAGAATTCTTTAAAAATGGTGATATAGATAATTTTGCAACT GGAGCGGTTAGTAACTGCAATAATGGTGGCTAA t08A.nt BB024 (SEQ ID NO:750) TGTAATTCTAATGATAATGACACTTTAAAAAACAATGCCCAACAAACAAAAAGACGGGGAAAG CGTGATTTAACCCAAAAAGAAACAACACAAGAAAAACCAAAATCTAAAGAAGAACTACTTAGA GAAAAGCTATCTGACGATCAAAAAACACATCTTGACTGGTTAAAACCCGCTTTAACTGGTGCTG GAGAATTTGACAAATTCTTAGAAAATGATGATGATAAAATAAAATCAGCACTTGATCATATAAA AACTCAACTTGATAGTTGTAATGGTGATCAAGCAGAACAACAAAAAACCACTTTCAAAACTGTG GTTACAGAATTCTTTAAAAATGGTGATATAGATAATTTTGCAACTGGAGCGGTTAGTAACTGCA ATAATGGTGGC f08A.aa BB024 (SEQ ID NO:751) ILIIKKGVTMKIINILFCLFLLMLNGCNSNDNDTLKNNAQQTKRRGKRDLTQKETTQEKPKSKEELLR EKLSDDQKTHLDWLKPALTGAGEFDKFLENDDDKIKSALDHIKTQLDSCNGDQAEQQKTTFKTVV TEFFKNGDIDNFATGAVSNCNNGG t08A.aa BB024 (SEQ ID NO:752) CNSNDNDTLKNNAQQTKRRGKRDL51TQKETTQEKPKSKEELLREKLSDDQKTHLDWLKPALTGA GEFDKFLENDDDKIKSALDHIKTQLDSCNGDQAEQQKTTFKTVVTEFFKNGDIDNFATGAVSNCNN GG f09A.nt BB025 (SEQ ID NO:753) TGAATATTAATAATAAAAAAAGGAATAATAATGAAAATTATCAACATATTATTTTGTTTATTTT TACTAATGCTAAACGGCTGTAATTCTAATGATACTAATAATAGCCAAACAAAAAGTAGACAAAA ACGTGATTTAACCCAAAAAGAAGCAACACAAGAAAAACCTAAATCTAAAGAAGAACTTCTTAG AGAAAAGCTAAATGATAATCAAAAAACACACCTTGACTGGTTAAAAGAAGCTCTGGGCAATGA TGGAGAATTTAATAAATTTTTAGGATATGATGAAAGCAAAATAAAATCTGCACTTGATCATATA AAGAGTGAACTTGACAGTTGTACTGGAGATAAGGTTGAAAATAAAAATACCTTCAAGCAGGTC GTTCAGGAGGCCCTTAAAGGGGGCATAGACGGCTTTGAAAATACTGCAAGTAGTACGTGCAAA AATTCATAA t09A.nt BB025 (SEQ ID NO:754) TGTAATTCTAATGATACTAATAATAGCCAAACAAAAAGTAGACAAAAACGTGATTTAACCCAAA AAGAAGCAACACAAGAAAAACCTAAATCTAAAGAAGAACTTCTTAGAGAAAAGCTAAATGATA ATCAAAAAACACACCTTGACTGGTTAAAAGAAGCTCTGGGCAATGATGGAGAATTTAATAAAT TTTTAGGATATGATGAAAGCAAAATAAAATCTGCACTTGATCATATAAAGAGTGAACTTGACAG TTGTACTGGAGATAAGGTTGAAAATAAAAATACCTTCAAGCAGGTCGTTCAGGAGGCCCTTAAA GGGGGCATAGACGGCTTTGAAAATACTGCAAGTAGTACGTGCAAAAATTCA f09A.aa BB025 (SEQ ID NO:755) ILIIKKGIIMKIINILFCLFLLMLNGCNSNDTNNSQTKSRQKRDLTQKEATQEKPKSKEELLREKLNDN QKTHLDWLKEALGNDGEFNKFLGYDESKIKSALDHIKSELDSCTGDKVENKNTFKQVVQEALKGGI DGFENTASSTCKNS t09A.aa BB025 (SEQ ID NO:756) CNSNDTNNSQTKSRQKRDLTQKEA51TQEKPKSKEELLREKLNDNQKTHLDWLKEALGNDGEFNK FLGYDESKIKSALDHIKSELDSCTGDKVENKNTFKQVVQEALKGGIDGFENTASSTCKNS

TABLE 2 Closest matching sequences between the polypeptides of the present invention and sequences in GenBank and Derwent databases. GenSeq Access BLAST BLAST Query No. GenSeq Gene Description Score P-Value f01A.aa gil2690256 (AE000790) antigen, P35, putative [Borrelia burgdorferi] 1523 5.90E-206 f02A.aa gil2690286 (AE000790) B. burgdorferi predicted coding region BBA69 [Borrelia 1320 2.10E-174 f02A.aa gil2690285 (AE000790) B. burgdorferi predicted coding region BBA68 [Borrelia 278 7.50E-71 f02A.aa gil2690105 (AE000789) B. burgdorferi predicted coding region BBI38 [Borrelia 151 8.40E-54 f02A.aa gil2690092 (AE000789) antigen, P35, putative [Borrelia burgdorferi] 151 2.70E-48 f02A.aa gil2690183 (AE000787) antigen, P35, putative [Borrelia burgdorferi] 155 4.20E-22 f02A.aa gil2690106 (AE000789) B. burgdorferi predicted coding region BB139 [Borrelia 154 1.30E-21 f03A.aa gil2688051 (AE001 127) antigen, S2, putative [Borrelia burgdorferi] 1223 7.60E-164 f03A.aa gil1063419 S2 gene product [Borrelia burgdorferi] 116 3.00E-22 f03A.aa gil2690227 (AE000790) antigen, S2 [Borrelia burgdorferi] > pir|D70207|D70207 116 9.70E-22 f03A.aa gil2690128 (AE000788) protein p23 [Borrelia burgdorferi] > pir|C70257|C70257 110 5.70E-19 f03A.aa gil2689956 (AE000785) protein p23 [Borrelia burgdorferi] > pir|D70225|D70225 104 7.90E-15 f04A.aa gil2690078 (AE000784) B. burgdorferi predicted coding region BBH18 [Borrelia 1873 5.60E-250 f04A.aa gil2690192 (AE000787) B. burgdorferi predicted coding region BBJ13 [Borrelia 167 1.40E-15 f05A.aa gil2687919 (AE001117) B. burgdorferi predicted coding region BB0028 [Borrelia 696 4.20E-92 f06A.aa gil2690129 (AE000788) outer membrane protein [Borrelia burgdorferi] 884 4.80E-124 f06A.aa gil2690089 (AE000789) conserved hypothetical protein [Borrelia burgdorferi] 731 2.20E-118 f06A.aa gil520783 unknown [Borrelia burgdorferi] > gil551742 unknown [Borrelia 337 4.30E-58 f07A.aa gil2688608 (AE001168) flagellar filament outer layer protein (flaA) [Borrelia 1668 2.50E-224 f07A.aa gil1575447 Fla A protein [Borrelia burgdorferi] > gil1019754 orf [Borrelia 1645 3.60E-221 f07A.aa gil152896 flagellar filament surface antigen [Spirochaeta aurantia] 144 1.70E-38 f07A.aa gil155059 encloflagellar sheath protein [Treponema pallidum] 139 3.80E-28 f07A.aa gil433524 flagellin FlaA1 [Serpulina hyodysenteriae] > gil904393 endoflagellar 119 3.00E-26 f07A.aa pir|A32814| flagellar filament surface antigen - Spirochaeta aurantia 116 9.40E-11 A32814 f08A.aa gil1209837 lipoprotein [Borrelia burgdorferi] 508 2.10E-78 f08A.aa gil2121280 (AF000270) lipoprotein [Borrelia burgdorferi] > gil3095109 547 4.00E-70 f08A.aa gil1209873 lipoprotein [Borrelia burgdorferi] 303 3.70E-51 f08A.aa gil1209843 lipoprotein [Borrelia burgdorferi] 395 2.20E-49 f08A.aa gil1209849 lipoprotein [Borrelia burgdorferi] 219 2.60E-27 f08A.aa gil3095105 (AF046998) 2.9-8 lipoprotein [Borrelia burgdorferi] 234 4.30E-27 f08A.aa gil1209831 lipoprotein [Borrelia burgdorferi] 209 1.10E-22 f08A.aa gil3095107 (AF046999) 2.9-9 lipoprotein [Borrelia burgdorferi] 200 1.80E-22 f08A.aa gil1209857 lipoprotein [Borrelia burgdorferi] 200 2.50E-21 f08A.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia afzelii] 142 1.80E-11 8244 f09A.aa gil1209843 lipoprotein [Borrelia burgdorferi] 453 8.60E-67 f09A.aa gil2121280 (AF000270) lipoprotein [Borrelia burgdorferi] > gil3095109 379 1.00E-56 f09A.aa gil1209873 lipoprotein [Borrelia burgdorferi] 282 1.10E-45 f09A.aa gil1209837 lipoprotein [Borrelia burgdorferi] 357 7.10E-44 f09A.aa gil1209849 lipoprotein [Borrelia burgdorferi] 143 1.60E-13 f09A.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia afzelii] 111 3.60E-11 8244 f09A.aa gil3095105 (AF046998) 2.9-8 lipoprotein [Borrelia burgdorferi] 142 5.40E-13 f101.aa gil2688708 (AE001176) conserved hypothetical protein [Borrelia burgdorferi] 1099 4.50E-152 f105.aa gil2688693 (AE001175) B. burgdorferi predicted coding region BB0758 [Borrelia 1276 2.20E-177 f11-12.aa gil2690139 (AE000788) B. burgdorferi predicted coding region BBK01 [Borrelia 1473 4.70E-193 f11-12.aa gil2690030 (AE000786) B. burgdorferi predicted coding region BBG01 [Borrelia 1066 1.40E-138 f11-12.aa gil2690074 (AE000784) B. burgdorferi predicted coding region BBH37 [Borrelia 173 6.20E-93 f11-12.aa gil2690188 (AE000787) B. burgdorferi predicted coding region BBJ08 [Borrelia 192 2.70E-75 f11-4.aa gil2690150 (AE000788) B. burgdorferi predicted coding region BBK12 [Borrelia 1144 2.70E-147 f11-4.aa gil2690145 (AE000788) B. burgdorferi predicted coding region BBK07 [Borrelia 852 5.70E-127 f11-4.aa gil2690095 (AE000789) B. burgdorferi predicted coding region BBI10 [Borrelia 153 1.30E-34 f11-4.aa gil2690197 (AE000787) B. burgdorferi predicted coding region BBJ31 [Borrelia 115 1.40E-12 f11-4.aa gil2690219 (AE000787) B. burgdorferi predicted coding region BBJ45 [Borrelia 115 1.40E-12 f112-1.aa gil2690054 (AE000784) B. burgdorferi predicted coding region BBH06 [Borrelia 573 7.00E-75 f12.aa gil2688785 (AE001182) B. burgdorferi predicted coding region BB0838 [Borrelia 6008 0 f129.aa gil2688685 (AE001174) B. burgdorferi predicted coding region BB0739 [Borrelia 987 6.20E-133 f14-8.aa gil2689955 (AE000785) antigen, P35, putative [Borrelia burgdorferi] 385 2.70E-75 f14-8.aa gil2690120 (AE000789) B. burgdorferi predicted coding region BBI34 [Borrelia 330 2.60E-66 f14-8.aa gil2690052 (AE000784) antigen, P35, putative [Borrelia burgdorferi] 287 4.00E-64 f14-8.aa gil2690100 (AE000789) B. burgdorferi predicted coding region BBI16 [Borrelia 172 1.10E-38 f14-8.aa gil2690115 (AE000789) B. burgdorferi predicted coding region BBI28 [Borrelia 173 1.70E-28 f14-8.aa gil2690116 (AE000789) B. burgdorferi predicted coding region BBI29 [Borrelia 163 8.20E-24 f14-8.aa gil2690207 (AE000787) B. burgdorferi predicted coding region BBJ02 [Borrelia 220 1.90E-23 f14-8.aa gil2690099 (AE000789) B. burgdorferi predicted coding region BBI15 [Borrelia 140 3.60E-12 f14-8.aa gil2690125 (AE000788) antigen, P35, putative [Borrelia burgdorferi] 111 1.00E-11 f142.aa gil2688655 (AE001172) glutamate transporter (gltP) [Borrelia burgdorferi] 2233 7.19999999999982e- 311 f142.aa gnl|PID|e23 hypothetical protein [Bacillus subtilis] > gnl|PID|e1 182902 727 2.60E-156 3874 f142.aa gnl|PID|d10 Proton/sodium-glutamate symport protein (Glutamate-aspartate 762 6.60E-146 16231 f142.aa gil1574711 proton glutamate symport protein (gltP) [Haemophilus influenzae] 903 2.10E-131 f142.aa gil2983758 (AE000735) proton/sodium-glutamate symport protein [Aquifex 111 8.40E-36 f142.aa gil143000 proton glutamate symport protein [Bacillus stearothermophilus] 125 1.20E-30 f142.aa gil143002 proton glutamate symport protein [Bacillus caldotenax] 125 1.90E-28 f142.aa gnl|PID|e11 proton/sodium-glutamate symport protein [Bacillus subtilis] 122 2.20E-25 83024 f142.aa gnl|PID|d10 glutamate transporter [Caenorhabditis elegans] 121 1.80E-22 22697 f142.aa gil1255318 coded for by C. elegans cDNA cm08h9; coded for by C. elegans cDNA 121 2.10E-22 f142.aa gil2388712 (AF017105) amino acid transporter [Chlamydia psittaci] 135 3.60E-22 f142.aa gil2655021 (AF018259) glutamate transporter 5A [Ambystoma tigrinum] 125 7.70E-22 f142.aa gnl|PID|e14 gluT-R gene product [Clostridium perfringens] 199 4.60E-21 9542 f142.aa gil396412 gltP [Escherichia coli] > gil147160 proton-glutamate [Escherichia 109 7.90E-21 f147.aa gil2688656 (AE001172) NADH oxidase, water-forming (nox) [Borrelia burgdorferi] 2245 7.20E-303 f147.aa gil642030 NADH oxidase [Serpulina hyodysenteriae] 318 9.20E-105 f147.aa gil2650234 (AE001077) NADH oxidase (noxA-2) [Archeoglobus fulgidus] 303 2.90E-93 f147.aa gil2792490 (AF041467) coenzyme A disulfide reductase [Staphylococcus aureus] 194 2.60E-90 f147.aa gil2650383 (AE001088) NADH oxidase (noxA-1) [Archaeoglobus fulgidus] 286 3.30E-88 f147.aa gnl|PID|d10 H2O-forming NADH Oxidase [Streptococcus mutans] 369 4.30-85 09320 f147.aa gil49023 NADH peroxidase [Enterococcus faecalis ] > pir|S18332|S18332 NADH 638 3.20E-83 f147.aa gil1591361 NADH oxidase (nox) [Methanococcus jannaschii] > pir|A64381|A64381 535 4.80E-83 f147.aa gil2622461 (AE000898) NADH oxidase [Methanobacterium thermoautotrophicum] 303 8.40E-72 f147.aa gil47045 NADH oxidase [Enterococcus faecalis ] > pir|S26965|S26965 NADH 547 8.80E-71 oxidase f147.aa gil2650233 (AE001077) NADH oxidase (nox A-3) [Archaeoglobus fulgidus] 312 2.00E-63 f147.aa gil1674132 (AE000044) Mycoplasma pneumoniae, NADH oxidase: similar to 175 7.00E-61 f147.aa gil1045969 NADH oxidase [Mycoplasma genitalium] > pir|D64230|D64230 NADH 164 4.10E-51 f147.aa gil2648692 (AE000975) NADH oxidase (noxA-5) [Archaeoglobus fulgidus] 143 2.00E-40 f147.aa gil2983379 (AE000709) NADH oxidase [Aquifex aeolicus] 162 5.50E-30 f150.aa gil2688659 (AE001172) conserved hypothetical protein [Borrelia burgdorferi] 1319 2.70E-179 f150.aa gil2983887 (AE000743) hypothetical protein [Aquifex aeolicus] 238 1.40E-25 f150.aa gil2581796 (AF001974) putative Trk A [Thermoanaerobacter ethanolicus] 175 5.80E-23 f150.aa gil1377829 unknown [Bacillus subtilis] > gnl|PID|d 1007628 orf4 [Bacillus 212 1.50E-21 f150.aa gnl|PID|e11 similar to hypothetical proteins [Bacillus subtilis] 181 6.00E-17 85982 f150.aa gnl|PID|d10 hypothetical protein [Synechocystis sp.] > pir|S75999|S75999 128 3.70E-11 11497 f152.aa gil2688660 (AE001172) K+ transport protein (ntpJ) [Borrelia burgdorferi] 2200 2.40000000001213e- 313 f152.aa gil2983882 (AE000743) K+ transport protein homolog [Aquifex aeolicus] 239 3.60E-106 f152.aa gnl|PID|e11 similar to Na+-transporting ATP synthase [Bacillus subtilis] 158 6.60E-64 84940 f152.aa gnl|PID|e11 similar to Na+-transporting ATP synthase [Bacillus subtilis] 131 3.40E-62 85983 f152.aa gnl|PID|d10 Na+-ATPase subunit J [Synechocystis sp.] > pir|S75455|S75455 141 1.70E-55 18749 f152.aa gnl|PID|d10 Na+-ATPase subunit J [Enterococcus hirae] 209 4.00E-45 04799 f152.aa gil2581795 (AF001974) putative TrkG [Thermoanaerobacter ethanolicus] 149 2.20E-29 f152.aa gil1674061 (AE000036) Mycoplasma pneumoniae, Na(+) translocating ATPase 104 4.00E-28 f152.a gil1046024 Na+ ATPase subunit J [Mycoplasma genitalium] > pir|F64235|F64235 114 2.80E-27 Na+ f152.aa gil567062 HKT1 [Triticum aestivum] > pir|S47582|S47582 high-affinity potassium 137 2.00E-17 f154.aa gil2688664 (AE001172) B. burgdorferi predicted coding region BB0722 [Borrelia 2456 0 f157.aa gil2688641 (AE001171) rod shape-determining protein (mreB-2) [Borrelia 2300 0 f157.aa gil143657 endospore forming protein [Bacillus subtilis] 224 2.60E-61 f157.aa gil580938 internal open reading frame (AA 1-290) [Bacillus subtilis] 224 2.60E-61 f157.aa gil2982781 (AE000670) rod shape determining protein RodA [Aquifex aeolicus] 333 5.40E-61 f157.aa gil580937 spoVE gene product (AA 1-366) [Bacillus subtilis] > gnl|PID|e1185111 224 7.70E-59 f157.aa gil147695 rod-shape-determining protein [Escherichia coli] > gil1778551 340 6.10E-58 f157.aa gnl|PID|e32 sfr [Streptomyces coelicolor] 362 6.40E-58 8589 f157.aa gil1572976 rod shape-determining protein (mreB) [Haemophilus influenzae] 307 4.00E-56 f157.aa gnl|PID|e11 similar to cell-division protein [Bacillus subtilis] 203 2.60E-45 85075 f157.aa gil1469784 putative cell division protein ftsW [Enterococcus hirae] 231 6.90E-45 f157.aa gil1016213 strong sequence similarity to FtsW, RodA, and Spo V-E [Cyanophora 206 3.00E-41 f157.aa gnl|PID|d10 rod-shape-determining protein [Synechocystis sp.] 184 1.60E-38 19002 f157.aa gil146039 cell division protein [Escherichia coli] > gil40857 FtsW protein 104 8.30E-35 f157.aa gil1574692 cell division protein (ftsW) [Haemophilus influenzae] 114 3.30E-33 f157.aa gil1165286 FtsW [Borrelia burgdorferi] > gil2688164 (AE001137) cell division 170 6.20E-32 f17-6.aa gil2690100 (AE000789) B. burgdorferi predicted coding region BBI16 [Borrelia 1250 1.70E-164 f17-6.aa gil2690120 (AE000789) B. burgdorferi predicted coding region BBI34 [Borrelia 142 3.40E-59 f17-6.aa gil2690115 (AE000789) B. burgdorferi predicted coding region BBI28 [Borrelia 447 6.70E-56 f17-6.aa gil2690052 (AE000784) antigen, P35, putative [Borrelia burgdorferi] 182 1.10E-34 f17-6.aa gil2689955 (AE000785) antigen, P35, putative [Borrelia burgdorferi] 196 6.60E-34 f17-6.aa gil2690114 (AE000789) B. burgdorferi predicted coding region BBI27 [Borrelia 176 1.00E-16 f17-6.aa gnl|PID|d10 gene required for phosphoylation of oligosaccharides/has 178 2.80E-15 12343 f17-6.aa gil2690207 (AE000787) B. burgdorferi predicted coding region BBJ02 [Borrelia 114 3.50E-13 f17-6.aa gnl|PID|e32 (AJ000496) cyclic nucleotide-gated channel beta subunit 152 1.10E-11 9895 f170.aa gil2688652 (AE001171) B. burgdorferi predicted coding region BB0708 [Borrelia 524 2.60E-73 f186.aa gil2688622 (AE001169) B. burgdorferi predicted coding region BB0689 [Borrelia 792 1.80E-105 f186.aa gil2688622 (AE001169) B. burgdorferi predicted coding region BB0689 [Borrelia 792 1.80E-105 f19-2.aa gil2690120 (AE000789) B. burgdorferi predicted coding region BBI34 Borrelia 1341 2.70E-177 f19-2.aa gil2689955 (AE000785) antigen, P35, putative [Borrelia burgdorferi] 347 7.00E-53 f19-2.aa gil2690052 (AE000784) antigen, P35, putative [Borrelia burgdorferi] 254 7.70E-53 f19-2.aa gil2690100 (AE000789) B. burgdorferi predicted coding region BBI16 [Borrelia 142 6.60E-50 f19-2.aa gil2690115 (AE000789) B. burgdorferi predicted coding region BBI28 [Borrelia 144 7.60E-34 f19-2.aa gil2690116 (AE000789) B. burgdorferi predicted coding region BBI29 [Borrelia 183 2.20E-21 f19-2.aa gil2690207 (AE000787) B. burgdorferi predicted coding region BBJ02 [Borrelia 171 2.00E-16 f19-2.aa gil2690099 (AE000789) B. burgdorferi predicted coding region BBI15 [Borrelia 166 1.20E-15 f19-2.aa gil2690125 (AE000788) antigen, P35, putative [Borrelia burgdorferi] 122 5.70E-14 f19-4.aa gil2690116 (AE000789) B. burgdorferi predicted coding region BBI29 [Borrelia 1129 1.30E-150 f19-4.aa gil2690099 (AE000789) B. burgdorferi predicted coding region BBJ15 [Borrelia 260 3.00E-30 f19-4.aa gil2689955 (AE000785) antigen, P35, putative [Borrelia burgdorferi] 180 1.80E-23 f19-4.aa gil2690120 (AE000789) B. burgdorferi predicted coding region BBI34 [Borrelia 183 1.50E-21 f19-4.aa gil2690052 (AE000784) antigen, P35, putative [Borrelia burgdorferi] 192 1.20E-19 f19-4.aa gil2690207 (AE000787) B. burgdorferi predicted coding region BBJ02 [Borrelia 149 8.90E-14 f19-4.aa gil2690098 (AE000789) B. burgdorferi predicted coding region BBI14 [Borrelia 138 8.00E-12 f19-6.aa gil2690115 (AE000789) B. burgdorferi predicted coding region BBI28 [Borrelia 995 1.20E-131 f19-6.aa gil2690100 (AE000789) B. burgdorferi predicted coding region BBI16 [Borrelia 447 3.00E-55 f19-6.aa gil2689955 (AE000785) antigen, P35, putative [Borrelia burgdorferi] 219 2.00E-36 f19-6.aa gil2690120 (AE000789) B. burgdorferi predicted coding region BBI34 [Borrelia 144 3.50E-34 f19-6.aa gil2690052 (AE000784) antigen, P35, putative [Borrelia burgdorferi] 130 6.30E-12 f196.aa gil2688620 (AE001169) methyl-accepting chemotaxis protein (mcp-5) [Borrelia 3093 0 f196.aa gil2688621 (AE001169) methyl-accepting chemotaxis protein (mcp-4) [Borrelia 615 1.90E-83 f196.aa gil496484 tlpC gene product [Bacillus subtilis] > pir|I40496|I40496 methylation 180 6.90E-28 f196.aa gnl|PID|d10 methyl-accepting chemotaxis protein TlpC [Bacillus subtilis] 180 4.90E-27 07002 f196.aa gnl|PID|e11 methyl-accepting chemotaxis protein [Bacillus subtilis] 162 5.10E-25 73493 f196.aa gil882594 ORF_f506 [Escherichia coli] > gil1789453 (AE000389) aerotaxis 204 1.70E-24 f196.aa gil148350 tas [Enterobacter aerogenes] > pir|D32302|D32302 probable aspartate 179 1.80E-24 f196.aa gil1066850 putative [Rhodobacter capsulatus] > pir|JC4735|JC4735 207 1.80E-24 f196.aa gil154381 chemoreceptor [Salmonella typhimurium] > pir|A47178|A47178 230 2.00E-24 f196.aa gil459690 transmembrane receptor [Bacillus subtilis] > gnl|PID|e1185997 212 1.40E-23 f196.aa gil805015 MCPA protein [Rhodobacter sphaeroides] > pir|S70094|S54262 237 2.10E-23 f196.aa gil40424 mcpA gene product [Caulobacter crescentus] > pir|S23064|S23064 mcpA 238 7.30E-23 f196.aa gil144913 sensory transducer protein [Clostridium thermocellum] 227 8.90E-23 f196.aa gil1061063 Trg sensory transducer protein [Escherichia coli] 211 2.40E-20 f196.aa gnl|PID|d10 Methyl-accepting chemotaxis protein III (MCP-III) (Ribose and 211 2.50E-20 15762 f197.aa gil2688621 (AE001169) methyl-accepting chemotaxis protein (mcp-4) [Borrelia 3724 0 f197.aa gil2688620 (AE001169) methyl-accepting chemotaxis protein (mcp-5) [Borrelia 615 8.40E-83 f197.aa gil1066850 putative [Rhodobacter capsulatus] > pir|JC4735|JC4735 227 9.80E-27 f197.aa gil882594 ORF_f506 [Escherichia coli] > gil1789453 (AE000389) aerotaxis 217 1.00E-26 f197.aa gil154381 chemoreceptor [Salmonella typhimurium] > pir|A47178|A47178 239 2.80E-25 f197.aa gil496484 tlpC gene product [Bacillus subtilis] > pir|I40496|I40496 methylation 202 5.10E-25 f197.aa gnl|PID|d10 methyl-accepting chemotaxis protein TlpC [Bacillus subtilis] 202 5.10E-25 07002 f197.aa gil2564665 (AF022807) putative methyl accepting chemotaxis protein [Rhizobium 212 7.20E-24 f197.aa gil459691 transmembrane receptor [Bacillus subtilis] > gnl|PID|e1185996 215 1.10E-23 f197.aa gil43218 serine chemoreceptor [Escherichia coli] > bbsl127562 serine 236 2.80E-23 f197.aa gil537197 CG Site No. 63; alternate gene name cheD [Escherichia coli] 236 2.90E-23 f197.aa gil148077 methyl-accepting chemotaxis protein I [Escherichia coli] > gil2367378 236 2.90E-23 f197.aa gnl|PID|1d10 transducer [Pseudomonas aeruginosa] 178 4.20E-23 09948 f197.aa gil148349 tse [Enterobacter aerogenes] > pir|C32302|C32302 serine transducer 234 5.50E-23 f197.aa gil2626835 chemotactic transducer [Pseudomonas aeruginosa] 177 5.70E-23 f200.aa gil2688600 (AE001168) ribose/galactose ABC transporter, permease protein 1887 5.10E-266 f200.aa gnl|PID|e31 unknown [Bacillus subtilis] > gnl|PID|el184234 similar to 283 1.50E-63 1453 f200.aa gil2649711 (AE001042) ribose ABC transporter, permease protein (rbsC-1) 202 1.10E-47 f200.aa gil2130609 (AF000308) putative polytopic protein [Mycoplasma fermentans] 119 2.10E-27 f200.aa gnl|PID|e31 unknown [Bacillus subtilis] > gnl|PID|e1184235 similar to 112 1.10E-18 1493 f200.aa gil950073 membrane forming protein [Mycoplasma capricolum] > pir|S77790|S77790 161 5.60E-16 f200.aa gil2688599 (AE001168) ribose/galactose ABC transporter, permease protein 108 2.00E-14 f208.aa gil2688610 (AE001168) B. burgdorferi predicted coding region BB0674 [Borrelia 1726 6.70E-244 f21-4.aa gil1197833 Bbk2.11 [Borrelia burgdorferi] > pir|S70531|S70531 bbk2.11 protein 474 3.00E-70 f21-4.aa gil2627267 ErpL [Borrelia burgdorferi] 477 6.30E-69 f21-4.aa gil1707281 putative outer membrane protein [Borrelia burgdorferi] 503 6.60E-66 f21-4.aa gil896042 OspF [Borrelia burgdorferi] > pir|S70532|S70532 outer surface protein 503 6.60E-66 f21-4.aa gil1707287 putative outer membrane protein [Borrelia burgdorferi] 489 3.00E-60 f21-4.aa gil1707290 putative outer surface protein [Borrelia burgdorferi] 342 3.20E-49 f21-4.aa gil1663633 ErpK [Borrelia burgdorferi] 268 1.70E-48 f21-4.aa gil466482 outer surface protein F [Borrelia burgdorferi] > pir|I40287|I40287 321 3.80E-38 f21-4.aa gil896038 BbK2.10 precursor [Borrelia burgdorferi] > pir|S70534|S70534 bbK2.10 121 3.90E-34 f21-4.aa gil896040 BbK2.10 precursor [Borrelia burgdorferi] > pir|S70533|S70533 bbK2.10 118 2.30E-33 f21-4.aa gil1051120 outer surface protein G [Borrelia burgdorferi] > gil1373118 ErpG 107 3.30E-33 f21-4.aa gil2444428 (AF020657) ErpX protein [Borrelia burgdorferi] 118 6.00E-14 f210.aa gil2688603 (AE001168) conserved hypothetical protein [Borrelia burgdorferi] 867 2.60E-116 f210.aa gil2688604 (AE001168) chemotaxis response regulator (cheY-3) [Borrelia 733 1.40E-97 f210.aa gil1408274 CheY [Borrelia burgdorferi] 720 9.00E-96 f210.aa gil1765976 chemotaxis protein CheY [Treponema pallidum] 405 6.60E-52 f210.aa gil142682 chemotactic response protein [Bacillus subtilis] > gnl|PID|185224 184 8.00E-30 f210.aa gil940149 CheY [Thermotoga maritima] 171 1.50E-27 f210.aa gil2649557 (AE001031) chemotaxis response regulator (cheY) [Archaeoglobus 168 1.50E-26 f210.aa gil620085 cheY gene product [Listeria monocytogenes] 183 3.00E-26 f210.aa gnl|PID|e24 YneI [Bacillus subtilis] > gil870926 response regulator 166 4.00E-24 9646 f210.aa gil149620 ORF2 [Leptospira borgpetersenii] > sp|P24086|YLB3_LEPIN 121 4.70E-22 HYPOTHETICAL f210.aa gil1408275 orfX; putative OrfX protein [Borrelia burgdorferi] 208 9.20E-22 f210.aa gil994802 cheY gene product [Halobacterium salinarium] > pir|A58645|S58645 CheY 139 8.90E-18 f210.aa gil143598 spoOF [Bacillus subtilis] > gil143601 SpoOF protein [Bacillus 113 4.70E-11 f216.aa gil2688586 (AE001167) conserved hypothetical protein [Borrelia burgdorferi] 804 1.20E-109 f216.aa gil1575446 orfA [Borrelia burgdorferi] 472 1.10E-91 f219.aa gil2688594 (AE001167) B. burgdorferi predicted coding region BB0664 [Borrelia 1122 3.10E-148 f22.aa gil2688779 (AE001181) B. burgdorferi predicted coding region BB0832 [Borrelia 1400 4.90E-188 f22.aa gil2688779 (AE001181) B. burgdorferi predicted coding region BB0832 [Borrelia 1400 4.90E-188 f221.aa gil2688596 (AE001167) B. burgdorferi predicted coding region BB0662 [Borrelia 692 2.60E-93 f229.aa gil2688591 (AE001167) oxygen-independent coproporphyrinogen III oxidase, 863 7.80E-120 f24-1.aa gil2039285 putative vls recombination cassette Vls6 [Borrelia burgdorferi] 924 1.80E-114 f24-1.aa gil2039284 putative vls recombination cassette Vls5 [Borrelia burgdorferi] 867 6.30E-107 f24-1.aa gil2039287 putative vls recombination cassette Vls8 [Borrelia burgdorferi] 824 1.50E-104 f24-1.aa gil2039289 putative vls recombination cassette Vls10 [Borrelia burgdorferi] 829 7.50E-102 f24-1.aa gil2039320 vmp-like sequence protein, VlsE [Borrelia burgdorferi] 644 1.10E-98 f24-1.aa gil2039288 putative vls recombination cassette Vls9 [Borrelia burgdorferi] 783 8.20E-96 f24-1.aa gil2039330 vmp-like sequence protein VlsE [Borrelia burgdorferi] 742 6.30E-95 f24-1.aa gil2039336 vmp-like sequence protein VlsE [Borrelia burgdorferi] 509 1.50E-92 f24-1.aa gil2039286 putative vls recombination cassette Vls7 [Borrelia burgdorferi] 754 6.60E-92 f24-1.aa gil2039324 vmp-like sequence protein VlsE [Borrelia burgdorferi] 488 8.10E-86 f24-1.aa gil2039316 vmp-like sequence protein VlsE [Borrelia burgdorferi] 531 1.70E-85 f24-1.aa gil2039312 vmp-like sequence protein VlsE [Borrelia burgdorferi] 531 1.20E-83 f24-1.aa gil2039326 vmp-like sequence protein VlsE [Borrelia burgdorferi] 476 2.00E-82 f24-1.aa gil2039332 vmp-like sequence protein VlsE [Borrelia burgdorferi] 474 5.10E-82 f24-1.aa gil2039328 vmp-like sequence protein VlsE [Borrelia burgdorferi] 420 3.50E-59 f253.aa gil2688567 (AE001165) Na+/H+ antiporter (nhaC-1) [Borrelia burgdorferi] 2247 0 f253.aa gil2688566 (AE001165) Na+/H+ antiporter (nhaC-2) [Borrelia burgdorferi] 609 6.40E-155 f253.aa gil2209268 Na+/H+ antiporter [Bacillus firmus] > pir|A41594|A41594 158 9.40E-15 f253.aa gil1574661 Na+/H+ antiporter (nhaC) [Haemophilus influenzae] 143 4.20E-14 f253.aa gnl|PID|e11 similar to Na+/H+ antiporter [Bacillus subtilis] 137 1.20E-11 85625 f253.aa gnl|PID|e32 hypothetical protein [Bacillus subtilis] > gnl|PID|e1182969 133 2.00E-11 4972 f265.aa gil2688555 (AE001164) conserved hypothetical protein [Borrelia burgdorferi] 1196 9.90E-161 f269.aa gil2688560 (AE001164) B. burgdorferi predicted coding region BB0624 [Borrelia 1654 5.50E-226 f28-2.aa gil2690174 (AE000788) B. burgdorferi predicted coding region BBK47 [Borrelia 1683 2.80E-222 f28-2.aa gil2690161 (AE000788) B. burgdorferi predicted coding region BBK49 [Borrelia 1068 2.20E-163 f28-3.aa gil2690138 (AE000788) immunogenic protein P37, putative [Borrelia burgdorferi] 281 6.00E-48 f28-3.aa gil2690127 (AE000788) immunogenic protein P37, [Borrelia burgdorferi] 209 3.20E-28 f28-3.aa gil2459605 immunogenic protein P37 [Borrelia burgdorferi] 208 4.50E-28 f28-3.aa gil2690137 (AE000788) immunogenic protein P37, putative [Borrelia burgdorferi] 172 5.50E-17 f29.aa gil2688764 (AE001180) B. burgdorferi predicted coding region BB0826 [Borrelia 869 8.20E-116 f290.aa gil2688537 (AE001162) serine-type D-Ala-D-Ala carboxypeptidase (dacA) 2046 1.50E-281 f290.aa gil143439 DD-carboxypeptidase [Bacillus subtilis] > pir|B42708|B42708 161 6.60E-36 f290.aa gnl|PID|e11 D-alanyl-D-alanine carboxypeptidase (penicilin binding 161 6.60E-36 85617 f290.aa gnl|PID|d10 Probable penicillin-binding protein. [Escherichia coli] 131 3.30E-28 16562 f290.aa splP376041 PENICILLIN-BINDING PROTEIN 6B PRECURSOR 135 9.10E-28 DACD_(—) SALTY f290.aa gil1572974 penicillin-binding protein 5 (dacA) [Haemophilus influenzae] 145 3.00E-27 f290.aa gil580849 D-alanine carboxypeptidase [Bacillus stearothermophilus] 170 4.10E-27 f290.aa gil778549 penicillin-binding protein 5 [Escherichia coli] > gil41212 precursor 152 3.20E-26 f290.aa gil142820 penicillin-binding protein 5 [Bacillus subtilis] 137 4.60E-26 f290.aa gil410134 penicillin-binding protein [Bacillus subtilis] > gnl|PID|e1185588 137 4.60E-26 f290.aa gil41218 precursor [Escherichia coli] 136 1.30E-25 f290.aa gnl|PID|d10 Penicillin-binding protein 6 precursor (D-alanyl-D-alanine 136 1.30E-25 15262 f290.aa gil1864022 penicillin binding protein 4 [Staphylococcus aureus] 155 5.10E-22 f290.aa gnl|PID|e15 penicillin binding protein 4 [Staphylococcus aureus] 155 5.10E-22 4145 f290.aa gnl|PID|e26 penicillin-binding protein 4 [Staphylococcus aureus] 155 5.10E-22 4682 f291.aa gil2688538 (AE001162) L-lactate permease (lctP) [Borrelia burgdorferi] 2473 0 f291.aa gnl|PID|e27 lactate premease [Streptococcus iniae] 586 1.20E-132 4704 f291.aa gil882504 ORF_f560 [Escherichia coli] > gil1789347 (AE000380) f560; This 560 aa 345 3.60E-95 f291.aa gil2313225 (AE000535) L-lactate permease (lctP) [Helicobacter pylori] 359 1.10E-94 f291.aa gil2313224 (AE000535) L-lactate permease (lctP) [Helicobacter pylori] 348 2.90E-93 f291.aa gil404693 L-lactate permease [Escherichia coli] > gil466741 aug is 3rd start 331 7.20E-82 f291.aa gnl|PID|e31 hypothetical protein [Bacillus subtilis] > gnl|PID|e1186107 330 9.00E-80 3006 f291.aa gnl|PID|d10 lactate permease [Bacillus subtilis] 300 1.70E-61 22632 f291.aa gnl|PID|e11 L-lactate permease [Bacillus subtilis] > pir|F69649|F69649 300 1.10E-60 82258 f291.aa gnl|PID|d10 homologue of L-lactate permease of E. coli [Bacillus 265 6.40E-56 09575 f291.aa gil2649804 (AE001049) L-lactate permease (lctP) [Archaeoglobus fulgidus] 170 1.50E-47 f291.aa gnl|PID|e28 L-Lactate permease [Sulfolobus solfataricus] 163 2.60E-44 3914 f291.aa gil1574148 L-lactate permease (lctP) [Haemophilus influenzae] 173 6.00E-35 f296.aa gil2688517 (AE001161) chaperonin, putative [Borrelia burgdorferi] 1276 4.40E-177 f296.aa gil840643 mucZ gene product [Coxiella burnetii] > pir|I40852|I40852 mucZ 101 7.90E-12 f3.aa gil2688797 (AE001183) B. burgdorferi predicted coding region BB0844 [Borrelia 1604 1.40E-211 f30.aa gil2688765 (AE001180) B. burgdorferi predicted coding region BB0825 [Borrelia 1343 2.00E-181 f301.aa gil2688521 (AE001161) methyl-accepting chemotaxis protein (mcp-3) [Borrelia 2756 0 f301.aa gil1805311 methyl-accepting chemotaxis protein B [Treponema denticola] 211 7.00E-20 f301.aa gil2688522 (AE001161) methyl-accepting chemotaxis protein (mcp-2) [Borrelia 189 2.80E-18 f301.aa gil2367665 (AF016689) Mcp-2 [Treponema pallidum] 189 3.50E-17 f301.aa gil2352917 (AF012922) methyl-accepting chemotaxis protein [Treponema 187 5.70E-17 f301.aa gil1354776 MCP-1 [Treponema pallidum] 189 5.90E-17 f301.aa gil2619023 (AF027868) YoaH [Bacillus subtilis] > gnl|PID|e1185333 similar to 184 2.80E-16 f301.aa gil1654421 transducer-HtB protein [Halobacterium salinarum] 177 2.20E-15 f301.aa gil415694 chemoreceptor [Desulfovibrio vulgaris] > pir|G36943|G36943 163 3.50E-15 f301.aa gil459691 transmembrane receptor [Bacillus subtilis] > gnl|PID|e1185996 163 4.90E-15 f301.aa gil2104730 ORF2 [Desulfurococcus sp. SY] 173 5.80E-15 f301.aa gil2914132 methyl accepting chemotaxis homolog [Treponema denticola] 170 1.10E-14 f301.aa gil459689 transmembrane receptor [Bacillus subtilis] > gnl|PID|e1185998 164 1.30E-14 f301.aa gil496484 tlpC gene product [Bacillus subtilis] > pir|I40496|I40496 methylation 170 3.80E-14 f301.aa gil2313163 (AE000530) methyl-accepting chemotaxis transducer (tlpC) 170 6.30E-14 f308.aa gil2688527 (AE001161) B. burgdorferi predicted coding region BB0592 [Borrelia 1227 1.70E-176 f31-2.aa gil2690202 (AE000787) B. burgdorferi predicted coding region BBJ36 [Borrelia 1771 7.20E-235 f31-2.aa gil2690200 (AE000787) B. burgdorferi predicted coding region BBJ34 [Borrelia 423 4.60E-88 f31.aa gil2688766 (AE001180) B. burgdorferi predicted coding region BB0824 [Borrelia 957 7.80E-133 f314.aa gil2688509 (AE001160) pfs protein (pfs-2) [Borrelia burgdorferi] 1329 7.40E-180 f314.aa gil2690087 (AE000789) pfs protein (pfs) [Borrelia burgdorferi] 335 1.50E-77 f314.aa gil2688288 (AE001143) pfs protein (pfs-1) [Borrelia burgdorferi] 266 1.00E-65 f314.aa gil2738591 (AFO12886) Pfs [Buchnera aphidicola] 115 1.70E-52 f314.aa gil1552737 similar to purine nucleoside phosphorylase (deoD) [Escherichia 133 6.90E-52 f314.aa gnl|PID|e11 similar to purine nucleoside phosphorylase [Bacillus 157 1.20E-49 83957 f314.aa gil147158 pfs [Escherichia coli] > gil457107 ORF [Escherichia coli] {SUB 9-219} 133 2.50E-42 f314.aa gil1574146 pfs protein (pfs) [Haemophilus influenzae] > pir|C64169|C64169 pfs 110 2.70E-37 f314.aa gil2267164 (AF009177) pfs protein homolog [Helicobacter pylori] 118 3.30E-23 f314.aa gil2313168 (AE000530) pfs protein (pfs) [Helocobacter pylori] 115 1.00E-22 f314.aa gil1777939 Pfs [Treponema pallidum] 102 1.90E-20 f314.aa gil2689970 (AE000785) B. burgdorferi predicted coding region BBE07 [Borrelia 191 1.50E-19 f314.aa gnl|PID|e24 unknown [Mycobacterium tuberculosis] > sp|Q10889|Y05A_MYCTU 105 7.60E-16 9405 f32-4.aa gil2690221 (AE000787) B. burgdorferi predicted coding region BBJ47 [Borrelia 1192 4.00E-163 f32-4.aa gil2689979 (AE000785) B. burgdorferi predicted coding region BBE16 [Borrelia 103 4.10E-11 f32.aa gil2688767 (AE001180) B. burgdorferi predicted coding region BB0823 [Borrelia 623 1.80E-81 f32.aa gil2688767 (AE001180) B. burgdorferi predicted coding region BB0823 [Borrelia 623 1.80E-81 f320.aa gil2688497 (AE001159) carboxypeptidase, putative [Borrelia burgdorferi] 1373 6.40E-186 f320.aa gil2529473 (AF006665) YokZ [Bacillus subtilis] 136 9.80E-28 f320.aa gil2415396 (AF015775) carboxypeptidase [Bacillus subtilis] > gnl|PID|e1185433 136 1.90E-27 f320.aa gil1209528 D,D-carboxypeptidase [Enterococcus faecalis] > 148 3.30E-16 sp|Q47746|VANY_ENTFA f320.aa gil155044 vanY [Transposon Tn1546] > gil149126 D,D-carboxypeptidase [Plasmid 142 1.60E-13 f328.aa gil2688502 (AE001159) CTP synthase (pyrG) [Borrelia burgdorferi] 869 6.10E-119 f328.aa gil1591801 CTP synthase (pyrG) [Methanococcus jannaschii] > pir|E64446|E64446 325 6.20E-59 f328.aa gil2650385 (AE001088) CTP synthase (pyrG) [Archaeoglobus fulgidus] 304 4.20E-54 f328.aa gil1399854 CTP synthetase [Synechococcus PCC7942] > sp|Q54775|PYRG_SYNP7 313 3.30E-52 CTP f328.aa gnl|PID|d10 CTP synthetase [Synechocystis sp.] > pir|S75840|S75840 CTP 295 1.80E-50 19032 f328.aa gil143597 CTP synthetase [Bacillus subtilis] > gil853762 CTP synthase [Bacillus 274 1.60E-49 f328.aa gil2983754 (AE000735) CTP synthetase [Aquifex aeolicus] 271 1.50E-46 f328.aa gil1574630 CTP synthetase (pyrG) [Haemophilus influenzae] > pir|F64181|F64181 234 1.90E-44 f328.aa gil413755 CTP synthetase [Spiroplasma citri] > sp|P52200|PYRG_SPICI CTP 231 3.00E-44 f328.aa gil2621483 (AE000826) CTP synthase [Methanobacterium thermoautotrophicum] 257 2.80E-40 f328.aa gil950067 CTP synthase [Mycoplasma capricolum] > pir|S77767|S77767 CTP 220 4.10E-39 synthase f328.aa gil904007 cytidine triphosphate synthetase precursor [Giardia intestinalis] 219 2.00E-38 f328.aa gil147478 CTP synthetase (EC 6.3.4.2) [Escherichia coli] 217 2.90E-38 f328.aa gil882674 CTP synthetase (Escherichia coli] > gil1789142 (AE000361) CTP 214 7.70E-38 f328.aa gil38688 CTP synthase [Azospirillum brasilense] > pir|I39496|S25101 CTP 132 3.20E-37 f342.aa gil2688495 (AE001158) B. burgdorferi predicted coding region BB0563 [Borrelia 944 5.30E-130 f346.aa gil1272356 phosphotransferase enzyme II [Borrelia burgdorferi] > gil2688474 828 1.10E-108 f346.aa gil145603 PTS enzyme III glc [Escherichia coli] > gil145605 PTS enzyme III glc 385 8.80E-53 f346.aa gil1314675 glucose-specific component IIA of the PTS system [Escherichia coli] 385 9.30E-53 f346.aa gil47658 III (Glc) (crr) (AA 1-169) [Salmonella typhimurium] 382 2.30E-52 f346.aa gil1574566 glucose phosphotransferase enzyme III-glc (crr) [Haemophilus 397 8.70E-50 f346.aa gil43819 nagE gene product [Klebsiella pneumoniae] > pir|S18607|S18607 349 2.80E-41 f346.aa gil146913 N-acetylglucosamine transport protein [Escherichia coli] 334 3.20E-39 f346.aa gil1072418 glcA [Staphylococcus carnosus] > pir|S46952|S46952 317 7.20E-37 f346.aa gil1072419 glcB [Staphylococcus carnosus] > pir|S63606|S46953 315 1.40E-36 f346.aa gil1146177 phosphotransferase system glucose-specific enzyme II [Bacillus 295 7.30E-36 f346.aa gil529001 PTS glucose-specific permease [Bacillus stearothermophilus] 294 8.80E-36 f346.aa gnl|PID|e11 alternate gene name: yzfA; similar to phosphotransferase 293 1.40E-33 82187 f346.aa gil580912 enzyme III-glucose [Bacillus subtilis] 257 1.20E-30 f346.aa gil602681 phosphocarrier protein (enzyme IIA) [Mycoplasma capricolum] 243 1.00E-28 f346.aa gil1432153 cellobiose-specific PTS permease [Klebsiella oxytoca] 257 1.20E-28 f352.aa gil2688482 (AE001157) B. burgdorferi predicted coding region BB0553 [Borrelia 2547 0 f352.aa gil2688482 (AE001157) B. burgdorferi predicted coding region BB0553 [Borrelia 1005 1.30E-132 f363.aa gil2688468 (AE001156) B. burgdorferi predicted coding region BB0543 [Borrelia 1109 5.40E-153 f368.aa gil2688450 (AE001155) conserved hypothetical integral membrane protein 1133 4.10E-157 f368.aa gil1787004 (AE000181) o234; This 234 aa ORF is 26 pct identical (15 gaps) to 417 1.40E-67 f368.aa gil2314055 (AE000601) conserved hypothetical integral membrane protein 129 3.50E-16 f368.aa gnl|PID|e12 S1R [Cowpox virus] 135 1.80E-14 89272 f368.aa gnl|PID|d10 24K membrane protein [Pseudomonas aeruginosa] 108 9.00E-13 03176 f368.aa gil41284 put. 23.5-kd protein [Escherichia coli] > gil1787205 (AE000199) 101 1.00E-11 f371.aa gil2688452 (AE001155) conserved hypothetical protein [Borrelia burgdorferi] 1066 3.60E-143 f371.aa gil2196997 Orf256 [Treponema pallidum] 154 1.10E-15 f373.aa gil2688453 (AE001155) zinc protease, putative [Borrelia burgdorferi] 3663 0 f373.aa gil1574200 hypothetical [Haemophilus influenzae] > pir|E64171|E64171 295 2.70E-67 f373.aa gil1787770 (AE000246) f931; residues 5-650 are 99 pct identical to YDDC_ECOLI 289 1.10E-57 f373.aa gil535004 cds106 gene product [Escherichia coli] 289 3.20E-57 f373.aa gil799369 metalloendopeptidase [Pisum sativum] 148 7.10E-28 f373.aa gil2827039 (AF008444) chloroplast processing enzyme [Arabidopsis thaliana] 150 1.70E-26 f373.aa gil2983709 (AE000732) processing protease [Aquifex aeolicus] 136 4.30E-24 f373.aa gil2314155 (AE000609) protease (pqqE) [Helicobacter pylori] > pir|D64646|D64646 115 5.30E-23 f378.aa gil2688458 (AE001155) B. burgdorferi predicted coding region BB0531 [Borrelia 1030 1.30E-136 f384.aa gil2688435 (AE001154) inositol monophosphatase [Borrelia burgdorferi] 1470 3.80E-201 f4-15.aa gil2690238 (AE000790) surface lipoprotein P27 [Borrelia burgdorferi] 1400 1.50E-185 f4-15.aa gil144008 P27 [Borrelia burgdorferi] > pir|S34995|S34995 surface lipoprotein 462 2.40E-96 f4-50.aa gil2690243 (AE000790) decorin binding protein B (dbpB) [Borrelia burgdorferi] 900 6.30E-117 f4-50.aa gil2062381 decorin binding protein B [Borrelia burgdorferi] 897 1.60E-116 f4-50.aa gil2809217 (AF042796) putative decorin-binding protein precursor [Borrelia 887 3.60E-115 f4-50.aa gil2809218 (AF042796) decorin-binding protein precursor [Borrelia burgdorferi] 172 2.00E-33 f4-50.aa gil2690249 (AE000790) decorin-binding protein A (dbpA) [Borrelia burgdorferi] 176 9.50E-33 f4-50.aa gil2062379 decorin binding protein A [Borrelia burgdorferi] 177 6.10E-32 f4-66.aa gil2690229 (AE000790) chpAI protein, putative [Borrelia burgdorferi] 807 1.60E-107 f4.aa gil2688787 (AE001183) conserved hypothetical integral membrane protein 2408 0 f4.aa gil2697115 (AF008219) unknown [Borrelia afzelii] 1138 1.90E-305 f4.aa gil1573583 H. influenzae predicted coding region HI0594 [Haemophilus 337 2.10E-109 f4.aa gil1788636 (AE000319) o513; This 513 aa ORF is 31 pct identical (30 gaps) to 327 9.10E-80 f4.aa gnl|PID|d10 homologue of hypothetical protein HI10594 of H. influenzae 357 5.40E-69 09571 f42-1.aa gil2689993 (AE000794) conserved hypothetical protein [Borrelia burgdorferi] 495 2.70E-62 f42-1.aa gil2689934 (AE000793) conserved hypothetical protein [Borrelia burgdorferi] 312 1.00E-37 f43-3.aa gil1209843 lipoprotein [Borrelia burgdorferi] 546 1.50E-69 f43-3.aa gil2121280 (AF000270) lipoprotein [Borrelia burgdorferi] > gil3095109 442 1.80E-55 f43-3.aa gil1209837 lipoprotein [Borrelia burgdorferi] 365 3.10E-55 f43-3.aa gil1209873 lipoprotein [Borrelia burgdorferi] 269 5.30E-32 f43-3.aa gil1209849 lipoprotein [Borrelia burgdorferi] 141 1.70E-13 f43-3.aa gil3095105 (AF046998) 2.9-8 lipoprotein [Borrelia burgdorferi] 140 9.60E-13 f43-3.aa gil3095107 (AF046999) 2.9-9 lipoprotein [Borrelia burgdorferi] 132 1.40E-11 f43.aa gil2688752 (AE001179) B. burgdorferi predicted coding region BB0811 [Borrelia 2337 6.60000000084856e- 315 f446.aa gil2688383 (AE001151) B. burgdorferi predicted coding region BB0464 [Borrelia 920 7.20E-124 f45-2.aa gil1699017 ErpB2 [Borrelia burgdorferi] > gil1373133.ErpB [Borrelia 364 7.50E-78 f45-2.aa gil2627270 ErpJ [Borrelia burgdorferi] 364 2.50E-77 f45-2.aa gil2627268 ErpM [Borrelia burgdorferi] 452 9.70E-60 f45-2.aa gil1373144 ErpD [Borrelia burgdorferi] 316 1.60E-58 f45-2.aa gil2444428 (AF020657) ErpX protein [Borrelia burgdorferi] 380 2.80E-55 f45-2.aa gil1051120 outer surface protein G [Borrelia burgdorferi] > gil1373118 ErpG 213 7.10E-35 f45-2.aa gil1663633 ErpK [Borrelia burgdorferi] 152 1.60E-21 f45-2.aa gnl|PID|e32 (AJ000496) cyclic nucleotide-gated channel beta subunit 198 2.80E-16 9895 f45-2.aa gil466482 outer surface protein F [Borrelia burgdorferi] > pir|I40287|I40287 111 5.70E-14 f45-2.aa gil2246532 ORF 73, contains large complex repeat CR 73 [Kaposi's 174 5.90E-14 f45-2.aa gil160299 glutamic acid-rich protein [Plasmodium falciparum] 169 1.00E-13 f45-2.aa gil1707287 putative outer membrane protein [Borrelia burgdorferi] 101 2.20E-13 f45-2.aa gil1633572 Herpes virus saimiri ORF73 homolog [Kaposi's sarcoma-associated 175 4.10E-13 f45-2.aa gnl|PID|d10 gene required for phosphoylation of oligosaccharides/has 166 5.60E-13 12343 f45-2.aa gil2690100 (AE000789B. burgdorferi predicted coding region BBI16 [Borrelia 161 2.70E-12 f457.aa gil2688369 (AE001150) B. burgdorferi predicted coding region BB0456 [Borrelia 1021 6.20E-139 f469.aa gil2688368 (AE001150) Na+/H + antiporter (napA) [Borrelia burgdorferi] 1544 1.10E-211 f47-2.aa gil1209849 lipoprotein [Borrelia burgdorferi] 742 2.30E-97 f47-2.aa gil1209857 lipoprotein [Borrelia burgdorferi] 407 7.80E-86 f47-2.aa gil1209831 lipoprotein [Borrelia burgdorferi] 393 5.00E-82 f47-2.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia burgdorferi] 321 2.60E-73 8245 f47-2.aa gil1209874 lipoprotein [Borrelia burgdorferi] 348 1.10E-64 f47-2.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia garinii] 333 1.40E-57 8239 f47-2.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia afzelii] 292 9.60E-44 8244 f47-2.aa gil3095107 (AF046999) 2.9-9 lipoprotein [Borrelia burgdorferi] 328 3.80E-40 f47-2.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia garinii] 320 1.70E-39 8242 f47-2.aa gil1209837 lipoprotein [Borrelia burgdorferi] 210 4.80E-29 f47-2.aa gil2121280 (AF000270) lipoprotein [Borrelia burgdorferi] > gil3095109 205 1.10E-27 f47-2.aa gil3095105 (AF046998) 2.9-8 lipoprotein [Borrelia burgdorferi] 217 6.30E-25 f47-2.aa gil1209873 lipoprotein [Borrelia burgdorferi] 113 2.40E-11 f477.aa gil2688350 (AE001149) fructose-bisphosphate aldolase (fba) [Borrelia 1506 3.60E-202 f477.aa gil882454 fructose 1,6-bisphosphate aldolase [Escherichia coli] > gil41423 651 1.10E-131 f477.aa gil2708661 (AF037440) fructose 1,6-bisphosphate aldolase [Edwardsiella 593 1.40E-124 f477.aa gil573507 fructose bisphosphate aldolase (fba) [Haemophilus influenzae] 560 8.50E-120 f477.aa gil671841 fructose 1,6-bisphosphate aldolase [Campylobacter jejuni] 856 3.80E-113 f477.aa gnl|PID|d10 fructose 1,6-bisphosphate aldolase [Schizosaccharomyces 749 1.70E-98 04756 f477.aa gil433637 yeast fructose-bisphate-aldolase [Saccharomyces cerevisiae] > gil3696 459 1.20E-92 f477.aa gnl|PID|e19 fructose 1,6-bisphosphate aldolase [Euglena gracilis] 701 6.30E-92 0134 f477.aa gil1334980 fructose 1,6-bisphosphate aldolase [Neurospora crassa] 647 1.50E-84 f477.aa gil40495 fructose bisphosphate aldolase [Corynebacterium glutamicum] 204 6.80E-37 f477.aa gnl|PID|e31 Fba [Mycobacterium tuberculosis] 207 1.50E-35 5480 f477.aa gil1045692 fructose bisphosphate aldolase [Mycoplasma genitalium] 108 2.10E-23 f477.aa gnl|PID|d10 hypothetical protein [Bacillus subtilis] > gnl|PID|e1184692 102 2.70E-15 03809 f488.aa gil2688338 (AE001148) DNA gyrase, subunit A (gyrA) [Borrelia burgdorferi] 3222 0 f488.aa gil1790876 DNA gyrase subunit A [Clostridium acetobutylicum] 822 1.80E-171 f488.aa gil2650163 (AE001072) DNA gyrase, subunit A (gyrA) [Archaeoglobus fulgidus] 483 1.10E-162 f488.aa gil40019 ORF 821 (aa 1-821) [Bacillus subtilis] > gnl|PID|d1005785 A subunit of 836 6.10E-159 f488.aa gil459929 gyrase A subunit [Pseudomonas aeruginosa] > sp|P48372|GYRA_PSEAE 418 7.00E-155 DNA f488.aa gil144206 DNA gyrase A [Campylobacter jejuni] > pir|A48902|A48902 DNA gyrase 508 7.50E-154 f488.aa gil466275 gyrase A [Mycobacterium tuberculosis] > sp|Q07702|GYRA_MYCTU 395 3.50E-152 DNA f488.aa gnl|PID|e26 GyrA [Mycobacterium tuberculosis] 395 2.00E-151 6924 f488.aa gil43485 DNA gyrase A subunit [Haloferax] > pir|S30571|S30571 DNA 275 6.10E-151 topoisomerase f488.aa gnl|PID|d10 (AB010081) A subunit of DNA gyrase [Bacillus sp.] 549 1.20E-150 25098 f488.aa gnl|PID|e21 DNA gyrase subunit A [Mycobacterium smegmatis] 388 5.90E-150 4031 f488.aa gil2731385 DNA gyrase [Serratia marcescens] 378 6.00E-148 f488.aa gnl|PID|e13 DNA topoisomerase (ATP-hydrolysing) [Mycobacterium smegmatis] 388 7.30E-147 7038 f488.aa gil41634 gyrA gene product (AA 1-875) [Escherichia coli] > gil41636 DNA gyrase 383 2.40E-146 f488.aa gil497648 DNA gyrase subunit A [Mycoplasma genitalium] 514 5.20E-146 f49-2.aa gil2039282 putative vls recombination cassette Vls3 [Borrelia burgdorferi] 943 2.30E-120 f49-2.aa gil2547241 vmp-like sequence protein VlsE [Borrelia burgdorferi] 434 4.10E-106 f49-2.aa gil2039324 vmp-like sequence protein VlsE [Borrelia burgdorferi] 458 3.00E-104 f49-2.aa gil2039281 putative vls recombination cassette Vls2 [Borrelia burgdorferi] 793 1.80E-100 f49-2.aa gil2039283 putative vls recombination cassette Vls4 [Borrelia burgdorferi] 729 4.60E-92 f49-2.aa gil2039308 vmp-like sequence protein VlsE [Borrelia burgdorferi] 652 1.40E-88 f49-2.aa gil2039288 putative vls recombination cassette Vls9 [Borrelia burgdorferi] 352 1.80E-88 f49-2.aa gil2039332 vmp-like sequence protein VlsE [Borrelia burgdorferi] 550 4.40E-88 f49-2.aa gil2039328 vmp-like sequence protein VlsE [Borrelia burgdorferi] 629 1.50E-85 f49-2.aa gil2039336 vmp-like sequence protein VlsE [Borrelia burgdorferi] 460 1.40E-82 f49-2.aa gil2039318 vmp-like sequence protein VlsE [Borrelia burgdorferi] 367 6.20E-82 f49-2.aa gil2039320 vmp-like sequence protein VlsE [Borrelia burgdorferi] 449 1.80E-77 f49-2.aa gil2483796 VlsE1 [Borrelia burgdorferi] 497 8.20E-76 f49-2.aa gil2039326 vmp-like sequence protein VlsE [Borrelia burgdorferi] 427 2.50E-64 f49-2.aa gil2039291 putative vls recombination cassette Vls13 [Borrelia burgdorferi] 409 1.30E-47 f494.aa gil2688346 (AE001148) B. burgdorferi predicted coding region BB0428 [Borrelia 547 8.20E-74 f5-14.aa gil2627268 ErpM [Borrelia burgdorferi] 1836 2.60E-236 f5-14.aa gil1373144 ErpD [Borrelia burgdorferi] 543 4.40E-87 f5-14.aa gil2627270 ErpJ [Borrelia burgdorferi] 503 4.30E-83 f5-14.aa gil1699017 ErpB2 [Borrelia burgdorferi] > gil1373133 ErpB [Borrelia 503 2.60E-82 f5-14.aa gil2444428 (AF020657) ErpX protein [Borrelia burgdorferi] 399 9.30E-57 f5-14.aa gnl|PID|e32 (AJ000496) cyclic nucleotide-gated channel beta subunit 228 1.50E-20 9895 f5-14.aa gnl|PID|d10 gene required for phosphoylation of oligosaccharides/has 203 8.70E-18 12343 f5-14.aa gil2246532 ORF 73, contains large complex repeat CR 73 [Kaposi's 197 3.30E-17 f5-14.aa gil1633572 Herpes virus saimiri ORF73 homolog [Kaposi's sarcoma-associated 192 1.20E-16 f5-14.aa gil3068583 (AF000580) Rep-like [Dictyostelium discoideum] 197 3.60E-16 f5-14.aa gil2690100 (AE000789) B. burgdorferi predicted coding region BBI16 [Borrelia 183 2.90E-15 f5-14.aa gil1825739 No definition line found [Caenorhabditis elegans] 168 1.60E-14 f5-14.aa gil3044185 (AF056936) mature parasite-infected erythrocyte surface antigen 166 2.00E-14 f5-14.aa gnl|PID|e34 E02A10.2 [Caenorhabditis elegans] 176 2.30E-14 9084 f5-14.aa gil1051120 outer surface protein G [Borrelia burgdorferi] > gil1373118 ErpG 157 3.30E-12 f5-15.aa gil2627267 ErpL [Borrelia burgdorferi] 1152 4.40E-147 f5-15.aa gil1197833 Bbk2.11 [Borrelia burgdorferi] > pir|S70531|S70531 bbk2.11 protein 856 3.30E-108 f5-15.aa gil896042 OspF [Borrelia burgdorferi] > pir|S70532|S70532 outer surface protein 325 1.00E-72 f5-15.aa gil1707281 putative outer membrane protein [Borrelia burgdorferi] 323 1.80E-72 f5-15.aa gil1707287 putative outer membrane protein [Borrelia burgdorferi] 322 6.60E-70 f5-15.aa gil466482 outer surface protein F [Borrelia burgdorferi] > pir|I40287|I40287 448 6.80E-68 f5-15.aa gil1707290 putative outer surface protein [Borrelia burgdorferi] 290 1.90E-52 f5-15.aa gil1663633 ErpK [Borrelia burgdorferi] 172 8.70E-43 f5-15.aa gil896038 BbK2.10 precursor [Borrelia burgdorferi] > pir|S70534|S70534 bbK2.10 153 1.10E-42 f5-15.aa gil896040 BbK2.10 precursor [Borrelia burgdorferi] > pir|S70533|S70533 bbK2.10 124 4.30E-39 f5-15.aa gil1051120 outer surface protein G [Borrelia burgdorferi]> gil1373118 ErpG 105 3.10E-23 f5-15.aa gil1373144 ErpD [Borrelia burgdorferi] 103 1.10E-14 f50.aa gil2688754 (AE001179) B. burgdorferi predicted coding region BB0806 [Borrelia 2651 0 f502.aa gil2688313 (AE001146) sensory transduction histidine kinase, putative 7570 0 f502.aa gnl|PID|d10 (AB006363) homologue of histidine kinase [Candida albicans] 296 3.80E-58 25877 f502.aa gil1354473 Os-1p [Neurospora crassa] 275 3.30E-57 f502.aa gil1679757 two-component histidine kinase CHK-1 [Glomerella cingulata] 382 4.20E-57 f502.aa gil1262208 Nik-1 [Neurospora crassa] > gil1262210 Nik-1 [Neurospora crassa] 273 6.30E-57 f502.aa gil2460283 (AF024654) hybrid histidine kinase DHKB [Dictyostelium discoideum] 273 3.90E-55 f502.aa gnl|PID|d10 sensory transduction histidine kinase [Synechocystis sp.] 288 8.50E-54 17789 f502.aa gil2623815 (AF030352) two component sensor [Pseudomonas aeruginosa] 252 4.00E-52 f502.aa gil939724 putative sensor kinase; regulatory protein for production of 252 1.80E-50 f502.aa gil151329 regulatory protein [Pseudomonas syringae] > sp|P48027|LEMA_PSESY 248 1.20E-49 f502.aa pir|B41863| two-component regulatory protein lemA - Pseudomonas syringae 248 1.30E-49 B41863 f502.aa gnl|PID|d10 sensory transduction histidine kinase [Synechocystis sp.] 252 2.10E-49 18725 f502.aa gnl|PID|d10 sensor-regulator protein [Escherichia coli] > gil1789149 262 6.20E-49 02185 f502.aa gil463195 pectate lyase [Pseudomonas viridiflava] 247 7.50E-49 f502.aa gnl|PID|d10 sensory transduction histidine kinase [Synechocystis sp.] 244 1.00E-48 18731 f51-2.aa gil2444428 (AF020657) ErpX protein [Borrelia burgdorferi] 1755 2.20E-227 f51-2.aa gil2627268 ErpM [Borrelia burgdorferi] 399 3.20E-57 f51-2.aa gil1373144 ErpD [Borrelia burgdorferi] 282 2.20E-50 f51-2.aa gil2627270 ErpJ [Borrelia burgdorferi] 271 6.00E-34 f51-2.aa gil1699017 ErpB2 [Borrelia burgdorferi] > gil1373133 ErpB [Borrelia 271 2.50E-33 f51-2.aa gil1051120 outer surface protein G [Borrelia burgdorferi] > gil1373118 ErpG 109 3.70E-22 f51-2.aa gnl|PID|d10 gene required for phosphoylation of oligosaccharides/has 203 5.40E-18 12343 f51-2.aa gil1707287 putative outer membrane protein [Borrelia burgdorferi] 111 7.50E-18 f51-2.aa gil896042 OspF [Borrelia burgdorferi] > pir|S70532|S70532 outer surface protein 111 2.10E-17 f51-2.aa gil1707281 putative outer membrane protein [Borrelia burgdorferi] 111 7.50E-17 f51-2.aa gnl|PID|e32 (AJ000496) cyclic nucleotide-gated channel beta subunit 198 1.60E-16 9895 f51-2.aa gil2246532 ORF 73, contains large complex repeat CR 73 [Kaposi's 176 2.30E-14 f51-2.aa gnl|PID|e34 E02A10.2 [Caenorhabditis elegans] 170 2.10E-13 9084 f51-2.aa gil160299 glutamic acid-rich protein [Plasmodium falciparum] 157 7.30E-12 f516.aa gil2688326 (AE001146) B. burgdorferi predicted coding region BB0409 [Borrelia 1096 2.00E-150 f517.aa gil2688320 (AE001146) PTS system, fructose-specific IIABC component (fruA-1) 1637 2.30E-228 f517.aa gnl|PID|e11 similar to fructose phosphotransferase system enzyme II 256 4.00E-88 83221 f517.aa gil396296 similar to phosphotransferase system enzyme II [Escherichia coli] 305 9.10E-86 f517.aa gil405893 fructose-specific IIBC component [Escherichia coli] > gil450372 224 4.30E-84 f517.aa gil151932 fructose enzyme II [Rhodobacter capsulatus] > gil46021 fructose 222 4.70E-79 f517.aa gil1573422 frustose-permease IIBC component (fruA) [Haemophilus influenzae] 225 6.90E-69 f517.aa gil2688554 (AE001164) PTS system, fructose-specific IIABC component (fruA-2) 236 8.20E-66 f517.aa gnl|PID|e11 phosphotransferase system (PTS) fructose-specific enzyme IIBC 195 2.80E-65 85030 f517.aa gil155369 PTS enzyme-II fructose [Xanthomonas campestris] pir|B40944|B40944 187 8.10E-62 f517.aa gil305003 similar to fructose-specific phosphotransferase enzyme II 145 1.90E-39 f517.aa gnl|PID|d10 HrsA [Escherichia coli] > gil1786951 (AE000176) 148 2.80E-39 11544 f517.aa gil1813488 phosphotransferase enzyme II [Bacillus firmus] 226 3.90E-39 f517.aa gil757734 fruA gene product [Bacillus amyloliquefaciens] > pir|S59965|S59965 177 2.50E-36 f517.aa gnl|PID|d10 PTS SYSTEM, FRUCTOSE-SPECIFIC IIBC COMPONENT (EIIBC- 173 1.10E-34 16984 FRU) f517.aa gil1673731 (AE000010) Mycoplasma pneumoniae, fructose-permease IIBC 143 9.00E-33 component; f519.aa gil2688327 (AE001146) B. burgdorferi predicted coding region BB0406 [Borrelia 1060 5.70E-145 f519.aa gil2688328 (AE001146) B. burgdorferi predicted coding region BB0405 [Borrelia 261 1.20E-47 f520.aa gil2688328 (AE001146) B. burgdorferi predicted coding region BB0405 [Borrelia 1022 3.90E-138 f520.aa gil2688327 (AE001146) B. burgdorferi predicted coding region BB0406 [Borrelia 261 4.00E-47 f523.aa gil2688300 (AE001145) glutamate transporter, putative [Borrelia burgdorferi] 2007 9.90E-284 f526.aa gil2688309 (AE001145) B. burgdorferi predicted coding region BB0399 [Borrelia 1087 1.60E-145 f527.aa gil2688310 (AE001145) B. burgdorferi predicted coding region BB0398 [Borrelia 1814 7.60E-249 f541.aa gil508421 antigen P39 [Borrelia burgdorferi] > gil2688281 (AE001143) basic 1706 5.40E-230 f541.aa gil1753225 BmpA protein [Borrelia burgdorferi] 1698 6.80E-229 f541.aa gnl|PID|e11 bmpA (p39, ORF1) [Borrelia burgdorferi] 1695 1.70E-228 72833 f541.aa gnl|PID|e11 membrane protein A [Borrelia burgdorferi] > gil516592 membrane 1642 3.40E-221 72835 f541.aa gnl|PID|e11 membrane protein A [Borrelia burgdorferi] 1638 1.20E-220 72834 f541.aa gnl|PID|e11 bmpA (p39, ORF1) [Borrelia burgdorferi] 1551 1.00E-208 72828 f541.aa gnl|PID|e11 membrane protein A [Borrelia afzelii] 1502 5.60E-202 72829 f541.aa gnl|PID|e11 membrane protein A [Borrelia afzelii] 1499 1.40E-201 72831 f541.aa gnl|PID|e11 membrane protein A [Borrelia garinii] 1496 3.70E-201 72837 f541.aa gnl|PID|e11 membrane protein A [Borrelia afzelii] 1493 9.60E-201 72830 f541.aa gnl|PID|e11 membrane protein A [Borrelia garinii] 1488 4.60E-200 72838 f541.aa gnl|PID|e23 membrane protein A [Borrelia garinii] 1216 1.20E-162 7214 f541.aa gnl|PID|e23 membrane protein A [Borrelia garinii] 1211 5.90E-162 7209 f541.aa gnl|PID|e23 membrane protein A [Borrelia garinii] 1098 2.00E-146 7236 f541.aa gil2688282 (AE001143) basic membrane protein B (bmpB) [Borrelia burgdorferi] 518 1.20E-123 f542.aa gil508422 [Borrelia burgdorferi immunodominant antigen P39 gene, complete 711 1.70E-95 f542.aa gil2688282 (AE001143) basic membrane protein B (bmpB) [Borrelia burgdorferi] 711 1.70E-95 f542.aa gil551744 membrane lipoprotein [Borrelia burgdorferi] 708 8.60E-95 f542.aa gnl|PID|e11 bmpB (p39, ORF2) [Borrelia burgdorferi] 699 8.20E-94 72836 f542.aa gnl|PID|e11 bmpB (p39, ORF2) [Borrelia afzelii] 634 1.00E-84 72832 f542.aa gnl|PID|e11 bmpB (p39, ORF2) [Borrelia garinii] 613 9.20E-82 72839 f542.aa gnl|PID|e23 membrane protein A [Borrelia garinii] 153 1.70E-32 7209 f532.aa gnl|PID|e11 bmpA (p39, ORF1) [Borrelia burgdorferi] 144 3.80E-32 72828 f542.aa gnl|PID|e23 membrane protein A [Borrelia garinii] 153 2.00E-31 7214 f542.aa gil1753225 BmpA protein [Borrelia burgdorferi] 155 2.80E-31 f542.aa gnl|PID|e11 bmpA (p39, ORF1) [Borrelia burgdorferi] 155 2.80E-31 72833 f542.aa gil508421 antigen P39 [Borrelia burgdorferi] > gil2688281 (AE001143) basic 155 2.80E-31 f542.aa gnl|PID|e11 membrane protein A [Borrelia garinii] 156 1.00E-30 72837 f542.aa gnl|PID|e11 membrane protein A [Borrelia afzelii] 144 1.90E-30 72829 f542.aa gnl|PID|e11 membrane protein A [Borrelia afzelii] 144 2.70E-30 72830 f544.aa gil2688284 (AE001143) Mg2+ transport protein (mgtE) [Borrelia burgdorferi] 860 4.20E-119 f544.aa gil1753228 MgtE [Borrelia burgdorferi] 855 2.20E-118 f544.aa gil619724 MgtE [Bacillus firmus] > pir|I40201|I40201 mgtE protein - Bacillus 176 3.70E-37 f544.aa gil780282 extended ORF of mgtE gene; transcription from this start point is 182 1.30E-34 f544.aa gnl|PID|e31 unknown [Mycobacterium tuberculosis] 183 4.50E-31 5479 f544.aa gnl|PID|d10 Mg2+ transporter [Synechocystis sp.] > pir|S77552|S77552 Mg2+ 165 4.60E-31 18132 f544.aa gnl|PID|e11 (AJ002571) YkoK [Bacillus subtilis]> gnl|PID|e1183350 similar 142 2.30E-30 81529 f544.aa gil2621701 (AE000843) Mg2+ transporter [Methanobacterium thermoautotrophicum] 142 3.20E-21 f545.aa gil2688284 (AE001143) Mg2+ transport protein (mgtE) [Borrelia burgdorferi] 860 4.20E-119 f545.aa gil1753228 MgtE [Borrelia burgdorferi] 855 2.20E-118 f545.aa gil619724 MgtE [Bacillus firmus] > pir|I40201|I40201 mgtE protein - Bacillus 176 3.70E-37 f545.aa gil780282 extended ORF of mgtE gene; transcpription from this start point is 182 1.30E-34 f545.aa gnl|PID|e31 unknown [Mycobacterium tuberculosis] 183 4.50E-31 5479 f545.aa gnl|PID|d10 Mg2+ transporter [Synechocystis sp.] > pir|S77552|S77552 Mg2+ 165 4.60E-31 18132 f545.aa gnl|PID|e11 (AJ002571) YkoK [Bacillus subtilis] > gnl|PID|e1183350 similar 142 2.30E-30 81529 f545.aa gil2621701 (AE000843) Mg2+ transporter [Methanobacterium thermoautotrophicum] 142 3.20E-21 f561.aa gil49245 lipoprotein [Borrelia burgdorferi] > gil2688271 (AE001142) lipoprotein 1000 1.30E-132 f561.aa gil495738 P22 [Borrelia burgdorferi] 982 3.70E-130 f577.aa gil2688261 (AE001141) B. burgdorferi predicted coding region BB0352 [Borrelia 1930 4.00E-264 f584.aa gil2688246 (AE001140) B. burgdorferi predicted coding region BB0346 [Borrelia 1094 4.10E-147 f596.aa gil2688241 (AE001140) P26 [Borrelia burgdorferi] > pir|G70141|G70141 P26 1322 1.20E-180 f596.aa gil2281465 (AF000366) P26 [Borrelia burgdorferi] > gil2281465 (AF000366) P26 1010 5.90E-137 f598.aa gil2281462 (AF000366) oligopeptide permease homolog D [Borrelia burgdorferi] 652 1.20E-85 f598.aa gil143607 sporulation protein [Bacillus subtilis] 372 1.20E-45 f598.aa gnl|PID|e11 oligopeptide ABC transporter (ATP-binding protein) [Bacillus 372 1.20E-45 83166 f598.aa gil1574676 oligopeptide transport ATP-binding protein (oppD) [Haemophilus 344 6.70E-42 f598.aa gil677943 AppD [Bacillus subtilis] > gnl|PID|e1183156 oligopeptide ABC 344 8.00E-42 f598.aa gil1787051 (AE000185) o612; 48 pct identical (33 gaps) to 525 residues from 346 2.50E-41 f598.aa gil47346 AmiE protein [Streptococcus pneumoniae] > pir|S11152|S11152 amiE 338 1.10E-40 f598.aa gil47805 Opp D (AA 1-335) [Salmonella typhimurium] > sp|P04285|OPPD_SALTY 332 5.70E-40 f598.aa pir|A03413| oligopeptide transport protein oppD - Salmonella typhimurium 332 5.70E-40 QREBOT f598.aa gil1787499 (AE000223) oligopeptide transport ATP-binding protein OppD 332 5.90E-40 f598.aa gnl|PID|d10 Oligopeptide transport ATP-binding protein OppD [Escherichia 332 5.90E-40 15494 f598.aa gil495177 ATP binding protein [Lactococcus lactis] > sp|P50980|OPPD_LACLC 331 8.40E-40 f598.aa gnl|PID|e18 oligopeptidepermease [Steptococcus pyogenes] 331 1.10E-39 7587 f598.aa gil308850 ATP binding protein [Lactococcus lactis] > pir|A53290|A53290 329 1.60E-39 f598.aa gil2313399 (AE000548) dipeptide ABC transporter, ATP-binding protein (dppD) 322 2.30E-39 f6-21.aa gil2281468 (AF000948) OppAIV [Borrelia burgdorferi] > gil2689891 (AE000792) 565 4.30E-73 f6-21.aa gil2253286 (AF005657) plasminogen binding protein [Borrelia burgdorferi] 315 1.20E-37 f6-21.aa gil2688228 (AE001139) oligopeptide ABC transporter, periplasmic 314 1.60E-37 f6-21.aa gil2809544 (AF043071) oligopeptide permease periplasmic binding protein 314 1.60E-37 f6-21.aa gil2281457 (AF000366) oligopeptide permease homolog AI [Borrelia burgdorferi] 314 1.60E-37 f6-21.aa gil2688227 (AE001139) oligopeptide ABC transporter, periplasmic 290 3.90E-34 f6-21.aa gil2281458 (AF000366) oligopeptide permease homolog AII [Borrelia burgdorferi] 290 3.90E-34 f6-21.aa gil2281455 (AF000365) oligopeptide permease homolog AV [Borrelia burgdorferi] 279 9.90E-34 f6-21.aa gil2690261 (AE000790) oligopeptide ABC transporter, periplasmic 282 5.30E-33 f6-21.aa gil1616644 P30 [Borrelia burgdorferi] 271 6.70E-32 f6-21.aa gil2688226 (AE001139) oligopeptide ABC transporter, periplasmic 268 5.00E-31 f6-21.aa gil2281459 (AF000366) oligopeptide permease homolog AIII [Borrelia 268 5.00E-31 f6-21.aa gil2809546 (AF043071) oligopeptide permease periplasmic binding protein 268 5.00E-31 f6-21.aa bbsl161785 60 kda antigen [Borrelia coriaceae, C053, ATCC 4338, Peptide, 514 255 2.90E-30 f6-21.aa gil2983834 (AE000740) transporter (extracellular solute binding protein family 154 3.50E-14 f6-27.aa gil2689911 (AE000792) B. burgdorferi predicted coding region BBB09 [Borrelia 1773 7.30E-240 f6-5.aa gil2689905 (AE000792) B. burgdorferi predicted coding region BBB27 [Borrelia 932 7.50E-126 f600.aa gil2281461 (AF000366) oligopeptide permease homolog C [Borrelia burgdorferi] 731 1.40E-100 f600.aa gil2688244 (AE001140) oligopeptide ABC transporter, permease protein (oppC-1) 731 1.40E-100 f600.aa gil143606 sporulation protein [Bacillus subtilis] > pir|C38447|C38447 372 5.00E-48 f600.aa gil40007 OppC gene product [Bacillus subtilis] > gnl|PID|e1183165 oligopeptide 372 5.00E-48 f600.aa gil1574677 oligopeptide transport system permease protein (oppC)C [Haemophilus 372 7.30E-48 f600.aa gil47804 Opp C (AA 1-301) [Salmonella typhimurium] > pir|C29333|QREBOC 366 4.20E-47 f600.aa gnl|PID|d10 Oligopeptide transport system permease protein OppC. 366 4.20E-47 15493 f600.aa gnl|PID|e11 (AJ002571) DppC [Bacillus subtilis] > gnl|PID−e1183314 267 1.70E-42 81495 f600.aa gil1732315 transport system permease homolog [Listeria moncytogenes] 335 5.30E-42 f600.aa gil580851 dciAC [Bacillus subtilis] > sp|P26904|DPPC_BACSU DIPEPTIDE 258 1.50E-40 TRANSPORT f600.aa gnl|PID|d10 oligopeptide transport system permease protein [Synechocystis 240 2.50E-39 11164 f600.aa gil677947 AppC [Bacillus subtilis] > gnl|PID|e1183160 oligopeptide ABC 236 2.80E-37 f600.aa gil1813497 dipeptide transporter protein dppC [Bacillus firmus] 281 1.20E-35 f600.aa sp|Q10623| PUTATIVE PEPTIDE TRANSPORT PERMEASE PROTEIN 290 1.50E-35 Y021_MYC CY373.01C. TU f600.aa gil1532201 BldKA [Streptomyces coelicolor] 291 1.60E-35 f603.aa gil2281460 (AF000366) oligopeptide permease homolog B [Borrelia burgdorferi] 1522 5.80E-214 f603.aa gil1574678 dipeptide transport system permease protein (dppB) [Haemophilus 392 1.30E-100 f603.aa gnl|PID|e11 oligopeptide ABC transporter (permease) [Bacillus subtilis] 374 3.40E-96 83164 f603.aa gil580897 OppB gene product [Bacillus subtilis] > pir|S15231|B38447 373 6.60E-96 f603.aa gil47803 OppB (AA1-306) [Salmonella typhimurium] > pir|B29333|QREBOB 371 6.70E-96 f603.aa gil1787497 (AE000223) oligopeptide transport system permease protein OppB 364 3.50E-95 f603.aa gnl|PID|d10 Oligopeptide transport system permease protein OppB 357 3.50E-94 15492 f603.aa gil580850 dciAB [Bacillus subtilis] > gnl|PID|e1181494 (AJ002571) DppB 350 9.10E-90 f603.aa gil551726 sporulation protein [Bacillus subtilis] > gil143605 sporulation 374 2.40E-87 f603.aa gil349226 transmembrane protein [Escherichia coli] > gil466682 dppB 293 9.60E-79 f603.aa gil1787053 (AE000185) o306; This 306 aa ORF is 46 pct identical (32 gaps) to 284 3.80E-77 f603.aa gil972895 DppB [Haemophilus influenzae] > gil1574114 dipeptide transport system 301 2.50E-76 f603.aa gil2182464 (AE000098) Y4tP [Rhizobium sp. NGR234] > sp|Q53191|Y4TP_RHISN 294 9.10E-74 f603.aa gil2983140 (AE000692) transporter (OppBC family) [Aquifex aeolicus] 169 2.30E-73 f603.aa gil677946 AppB [Bacillus subtilis] > gnl|PID|e1183159 oligopeptide ABC 218 8.70E-73 f604.aa gil2281459 (AF000366) oligopeptide permease homolog AIII [Borrelia 2818 0 f604.aa gil2809546 (AF043071) oligopeptide permease periplasmic binding protein 2818 0 f604.aa gil2688226 (AE001139) oligopeptide ABC transporter, periplasmic 2823 0 f604.aa gil2688227 (AE001139) oligopeptide ABC transporter, periplasmic 1738 1.40E-234 f604.aa gil2281458 (AF000366) oligopeptide permease homolog AII [Borrelia burgdorferi] 1731 1.30E-233 f604.aa gil2281468 (AF000948) OppAIV [Borrelia burgdorfer] > gil2689891 (AE000792) 1675 3.60E-229 f604.aa gil2688228 (AE001139) oligopeptide ABC transporter, periplasmic 718 1.60E-204 f604.aa gil2809544 (AF043071) oligopeptide permease periplasmic binding protein 718 3.00E-204 f604.aa gil2253286 (AF005657) plasminogen binding protein [Borrelia burgdorferi] 718 4.10E-204 f604.aa gil2281457 (AF000366) oligopeptide permease homolog AI [Borrelia burgdorferi] 714 2.00E-203 f604.aa bbs|161785 60 kda antigen [Borrelia coriaceae, C053, ATCC 4338, Peptide, 514 704 1.20E-190 f604.aa gil2281455 (AF000365) oligopeptide permease homolog AV [Borrelia burgdorferi] 1402 1.80E-188 f604.aa gil2690261 (AE000790) oligopeptide ABC transporter, periplasmic 1400 3.40E-188 f604.aa gil1616644 P30 [Borrelia burgdorferi] 858 4.90E-117 f604.aa gil47802 Opp A (AA1-542) [Salmonella typhimurium] > gil47808 precursor 296 9.00E-114 f606.aa gil2281458 (AF000366) oligopeptide permease homolog AII [Borrelia burgdorferi] 2762 0 f606.aa gil2688227 (AE001139) oligopeptide ABC transporter, periplasmic 2774 0 f606.aa gil2281468 (AF000948) OppAIV [Borrelia burgdorferi] > gil2689891 (AE000792) 1817 6.50E-245 f606.aa gil2809546 (AF043071) oligopeptide permease periplasmic binding protein 1739 3.10E-234 f606.aa gil2688226 (AE001139) oligopeptide ABC transporter, periplasmic 1738 4.20E-234 f606.aa gil2281459 (AF000366) oligopeptide permease homolog AIII [Borrelia 1733 2.00E-233 f606.aa bbs|161785 60 kda antigen [Borrelia coriaceae, C053, ATCC 4338, Peptide 514 762 1.70E-202 f606.aa gil2281455 (AF000365) oligopeptide permease homolog AV [Borrelia burgdorferi] 1456 1.80E-195 f606.aa gil2690261 (AE000790) oligopeptide ABC transporter, periplasmic 1454 3.30E-195 f606.aa gil2253286 (AF005657) plasminogen binding protein [Borrelia burgdorferi] 751 2.00E-192 f606.aa gil2688228 (AE001139) oligopeptide ABC transporter, periplasmic 751 2.70E-192 f606.aa gil2809544 (AF043071) oligopeptide permease periplasmic binding protein 751 6.90E-192 f606.aa gil2281457 (AF000366) oligopeptide permease homolog AI [Borrelia burgdorferi] 748 2.40E-191 f606.aa gil1616644 P30 [Borrelia burgdorferi] 1220 7.30E-163 f606.aa gil47802 Opp A (AA1-542) [Salmonella typhimurium] > gil47808 precursor 285 7.80E-106 f607.aa gil2281457 (AF000366) oligopeptide permease homolog AI [Borrelia burgdorferi] 2694 0 f607.aa gil2253286 (AF005657) plasminogen binding protein [Borrelia burgdorferi] 2706 0 f607.aa gil2809544 (AF043071) oligopeptide permease periplasmic binding protein 2708 0 f607.aa gil2688228 (AE001139) oligopeptide ABC transporter, periplasmic 2714 0 f607.aa bbs|161785 60 kda antigen [Borrelia coriaceae, C053, ATCC 4338, Peptide, 514 1272 3.80E-242 f607.aa gil2809546 (AF043071) oligopeptide permease periplasmic binding protein 718 1.40E-204 f607.aa gil2688226 (AE001139) oligopeptide ABC transporter, periplasmic 718 3.60E-204 f607.aa gil2281459 (AF000366) oligopeptide permease homolog AIII [Borrelia 713 1.70E-203 f607.aa gil2688227 (AE001139) oligopeptide ABC transporter, periplasmic 751 2.40E-192 f607.aa gil2281458 (AF000366) oligopeptide permease homolog AII [Borrelia burgdorferi] 751 4.50E-192 f607.aa gil2281468 (AF000948) OppAIV [Borrelia burgdorferi] > gil2689891 (AE000792) 806 8.40E-189 f607.aa gil2690261 (AE000790) oligopeptide ABC transporter, periplasmic 601 1.20E-144 f607.aa gil2281455 (AF000365) oligopeptide permease homolog AV [Borrelia burgdorferi] 600 1.60E-144 f607.aa gil1616644 P30 [Borrelia burgdorferi] 709 5.40E-103 f607.aa gil47802 Opp A (AA1-542) [Salmonella typhimurium] > gil47808 precursor 261 8.50E-69 f611.aa gil2688231 (AE001139) B. burgdorferi predicted coding region BB0325 [Borrelia 1907 1.10E-261 f617.aa gil2688213 (AE001138) conserved hypothetical integral membrane protein 1574 2.70E-226 f617.aa gil2649711 (AE001042) ribose ABC transporter, permease protein (rbsC-1) 109 7.00E-12 f631.aa gil1165286 FtsW [Borrelia burgdorferi] > gil2688164 (AE001137) cell division 1820 4.00E-259 f631.aa gnl|PID|e22 membrane protein [Borrelia burgdorferi] > gnl|PID|e228289 ftsW 1815 2.10E-258 9592 f631.aa gil146039 cell division protein [Escherichia coli] > gil40857 FtsW protein 362 1.30E-60 f631.aa gil580938 internal open reading frame (AA 1-290) [Bacillus subtilis] 407 4.90E-55 f631.aa gnl|PID|e31 FtsW [Mycobacterium tuberculosis] > sp|O06223|FTWH_MYCTU 412 5.40E-55 5953 f631.aa gil580937 spoVE gene product (AA 1-366) [Bacillus subtilis] > gnl|PID|e1185111 410 2.90E-53 f631.aa gil143657 endospore forming protein [Bacillus subtilis] 405 1.20E-52 f631.aa gnl|PID|d10 rod-shape-determing protein [Synechocystis sp.] 358 3.10E-51 19002 f631.aa gnl|PID|e12 (AL022602) cell division protein FtsW [Mycobacterium leprae] 396 6.70E-51 87793 f631.aa gil1016213 strong sequence similarity to FtsW, RodA, and SpoV-E [Cyanophora 349 1.00E-50 f631.aa gil1574692 cell division protein (ftsW) [Haemophilus influenzae] 304 4.20E-50 f631.aa gnl|PID|e11 similar to cell-division protein [Bacillus subtilis] 281 1.80E-46 85075 f631.aa gil1469784 putative cell division protein ftsW [Enterococcus hirae] 247 1.60E-38 f631.aa gil1572976 rod shape-determining protein (mreB) [Haemophilus influenzae] 196 1.20E-37 f631.aa gil147695 rod-shape-determining protein [Escherichia coli] > gil1778551 194 5.00E-35 f635.aa gil1165282 orf7; Method: conceptual translation supplied by author [Borrelia 1166 1.00E-156 f635.aa gil1448949 ORF 224; The predicted gene product showed weak homology with the 621 2.80E-125 f647.aa gil2688180 (AE001137) flagellar protein (flbB) [Borrelia burgdorferi] 1032 1.00E-140 f647.aa gil1196323 putative [Borrelia burgdorferi] 1031 1.50E-140 f647.aa gil1165270 orf19; Method: conceptual translation supplied by author [Borrelia 1019 7.10E-139 f647.aa gil2108242 22.5K protein [Treponema pallidum] 200 4.70E-24 f65.aa gil2688737 (AE001178) B. burgdorferi predicted coding region BB0792 [Borrelia 1095 8.10E-148 f653.aa gil1165265 MotB [Borrelia burgdorferi] > gil1185054 flagellar motor apparatus 1220 1.70E-164 f653.aa gil1399286 MotB [Treponema phagedenis] 168 5.80E-57 f653.aa gil2196896 MotB [Treponema pallidum] 179 1.30E-49 f664.aa gil1185062 flagellar export protein [Borrelia burgdorferi] 1430 1.90E-199 f664.aa gil1165257 FlhB [Borrelia burgdorferi] > gil2688194 (AE001137) flagellar 1430 1.90E-199 f664.aa gil1216382 FlhB′ [Treponema pallidum] > pir|PC4115|PC4115 flagellar protein 272 5.30E-64 f664.aa gil395390 flagellar biosynethetic protein [Bacillus subtilis] 433 1.30E-61 f664.aa gnl|PID|e11 flagella-associated protein [Bacillus subtilis] 433 1.30E-61 85229 f664.aa gil1147737 third gene in fliQ operon; membrane protein homolog [Caulobacter 353 1.70E-46 f664.aa gil2313898 (AE000589) flagellar biosynthetic protein (flhB) [Helicobacter 203 1.20E-44 f664.aa gil2984250 (AE000768) flagellar biosynthetic protein FlhB [Aquifex aeolicus] 319 3.00E-44 f664.aa gil2459702 FlhB [Agrobacterium tumefaciens] 347 6.20E-44 f664.aa gil793892 flhB [Yersinia enterocolitica] > pir|S54213|S54213 flhB protein 330 1.30E-39 f664.aa gnl|PID|d10 Flagellar biosynthetic protein FlhB. [Escherichia coli] 325 2.20E-39 16420 f664.aa gil475126 yscU [Yersinia pseudotuberculosis] > gil2996233 (AF053946) Yop 309 9.80E-38 f664.aa gil497216 YscU [Yersinia enterocolitica] 308 1.40E-37 f664.aa gnl|PID|d10 flagellar protein FlhB [Salmonella typhimurium] 312 2.10E-37 07477 f664.aa gnl|PID|e28 secretion system apparatus, SsaU [Salmonella typhimurium] 312 8.20E-37 3684 f679.aa gil2688158 (AE001136) B. burgdorferi predicted coding region BB0259 [Borrelia 3714 0 f679.aa gnl|PID|d10 soluble lytic transglycosylase [Synechocystis sp.] 180 1.10E-25 11473 f679.aa gnl|PID|e11 similar to lytic transglycosylase [Bacillus subtilis] 108 2.10E-22 83177 f679.aa gil2984090 (AE000756) hypothetical protein [Aquifex acolicus] 111 9.30E-17 f680.aa gil2688153 (AE001136) bacitracin resistance protein (bacA) [Borrelia 769 3.90E-109 f680.aa gnl|PID|e11 similar to bacitracin resistance protein (undecaprenol 174 7.30E-18 85988 f680.aa gil2622542 (AE000905) bacitracin resistance protein [Methanobacterium 116 3.30E-16 f680.aa gil2984378 (AE000777) undecaprenol kinase [Aquifex aeolicus] 152 3.90E-15 f680.aa gil882579 CG Site No. 29739 [Excherichia coli] > gil1789437 (AE000387) 139 2.60E-12 f688.aa gil2688146 (AE001135) conserved hypothetical integral membrane protein 2497 0 f688.aa gil2649351 (AE001019) conserved hypothetical protein [Archaeoglobus fulgidus] 110 3.70E-18 f688.aa gil1592186 M jannaschii predicted coding region MJ1562 [Methanococcus 174 1.10E-16 f7-30.aa gil2690009 (AE000786) conserved hypothetical protein [Borrelia burgdorferi] 682 1.90E-90 f704.aa gil2688137 (AE001134) glycerol uptake facilitator (glpF) [Borrelia 1307 4.70E-181 f704.aa gil142997 glycerol uptake facilitator [Bacillus subtilis] > gnl|PID|e1182917 191 1.50E-50 f704.aa gil521003 C01G6.1 [Caenorhabditis elegans] 152 1.60E-50 f704.aa gil529582 water channel protein [Rattus norvegicus] > pir|I59266|I59266 water 142 5.80E-50 f704.aa dbjl|AB0005 (AB000507) aquaporin 7 [Rattus norvegicus] 155 1.30E-49 07_1 f704.aa pir|A57119| aquaporin 3-human 149 4.20E-44 A57119 f704.aa gil1109920 coded for by C. elegans cDNA cm16b11; strong similarity to MIP 168 9.30E-44 f704.aa gnl|PID|d10 (AB001325) aquaporin 3 [Homo sapiens] > sp|Q92482|AQP3_HUMAN 148 5.30E-43 19987 f704.aa gnl|PID|d10 (AB008775) aquaporin 9 [Homo sapiens] 144 1.40E-42 25786 f704.aa gil146188 glycerol diffusion facilitator [Escherichia coli] > gil305030 CG Site 146 1.30E-40 f704.aa gil1065485 strong similarity to the MIP family of transmembrane channel 179 1.40E-39 f704.aa sp|P31140| GLYCEROL UPTAKE FACILITATOR PROTEIN 146 3.30E-39 GLPF_SHI FL f704.aa gil2587035 (AF026270) PduF [Salmonella typhimurium] > sp|P37451|PDUF_SALTY 168 7.30E-39 f704.aa gil1399489 glycerol diffusion facilitator [Pseudomonas aeruginosa] 154 7.90E-39 f704.aa gil2649144 (AE001005) glycerol uptake facilitator, MIP channel (glpF) 150 1.30E-38 f707.aa gil2688143 (AE001134) B. burgdorferi predicted coding region BB0238 [Borrelia 1300 3.90E-176 f709.aa gil2688131 (AE001133) B. burgdorferi predicted coding region BB0236 [Borrelia 3437 0 f730.aa gil2688111 (AE001132) gufA protein [Borrelia burgdorferi] > pir|C70127|C70127 1376 3.00E-192 f730.aa gil1707057 coded for by C. elegans cDNA CEESS55F; coded for by C. elegans 235 2.80E-83 cDNA f730.aa gil2621542 (AE000831) conserved protein [Methanobacterium thermoautotrophicum] 259 1.10E-74 f730.aa gnl|PID|e18 gufA gene product [Myxococcus xanthus] > gil49253 orfX gene 175 2.30E-35 3440 f730.aa gil2984109 (AE000757) hypothetical protein [Aquifex aeolicus] 171 7.00E-28 f736.aa gil2688115 (AE001132) phosphate ABC transporter, periplasmic phosphate-binding 1403 2.10E-186 f736.aa gil2622858 (AE000929) phosphate-binding protein PstS [Methanobacterium 151 4.40E-30 f736.aa gil2622859 (AE000929) phosphate-binding protein PstS homolog [Methanobacterium 145 2.80E-24 f736.aa gnl|PID|d10 ORF108 [Bacillus subtilis] > gnl|PID|e1185766 alternate gene 120 1.20E-11 10224 f739.aa gil2688119 (AE001132) B. burgdorferi predicted coding region BB0213 [Borrelia 1139 1.10E-156 f742.aa gil2688100 (AE001131) surface-located membrane protein 1 (lmp1) [Borrelia 5654 0 f742.aa gil2621120 (AE000799) O-linked GlcNAc transferase [Methanobacterium 200 9.30E-22 f742.aa gil2621106 (AE000798) O-linked GlcNAc transferase [Methanobacterium 180 5.80E-17 f742.aa pir|E69190| conserved hypothetical protein MTH68 - Methanobacterium 154 1.60E-14 E69190 f742.aa gil1591608 transformation sensitive protein [Methanococcus jannaschii] 109 9.90E-14 f742.aa gil1589778 SPINDLY [Arabidopsis thaliana] 101 1.40E-13 f742.aa gil2984175 (AE000762) hypothetical protein [Aquifex aeolicus] 132 7.30E-13 f742.aa gil3037137 (AF056198) Hsp70/Hsp90 organizing protein homolog [Drosophila 105 5.40E-11 f743.aa gil2688104 (AE001131) B. burgdorferi predicted coding region BB0209 [Borrelia 1299 1.70E-174 f748.aa gil2688089 (AE001130) Lambda CII stability-governing protein (hflC) [Borrelia 1615 5.10E-220 f748.aa gil436158 putative integral membrane protease required for high frequency 191 4.80E-35 f748.aa gil1573107 Lambda CII stability-governing protein (hflC) [Haemophilus 193 4.90E-33 f748.aa gil507735 HflC [Vibrio parahaemolyticus] > sp|P40606|HFLC_VIBPA HFLC 212 6.10E-26 PROTEIN f752.aa gil2688092 (AE001130) 2585 0 f752.aa gil2984050 (AE000754) UDP-MurNac-tripeptide synthetase [Aquifex aeolicus] 202 9.10E-74 f752.aa gil40162 murE gene product [Bacillus subtilis] > gnl|PID|e1185108 157 6.40E-70 f752.aa gnl|PID|d10 UDP-MurNac-tripeptide synthetase [Synechocystis sp.] 166 5.20E-57 11466 f752.aa gnl|PID|e30 UDP-MurNac-tripeptide synthetase [Rickettsia prowazekii] 108 2.30E-51 7808 f752.aa gil1574688 UDP-MurNac-tripeptide synthetase (murE) [Haemophilus influenzae] 166 3.20E-50 f752.aa gnl|PID|e12 (AL022602) udp-n-acetylmuramoylalanyl-d-glutamate 183 3.20E-50 87797 f752.aa gnl|PID|e31 MurE [Mycobacterium tuberculosis] 181 4.10E-46 6022 f752.aa gil581032 UDP-MurNac-tripeptide synthetase (MurE) [Escherichia coli] 175 1.30E-41 f752.aa gil2177098 UDP-MurNac-Dipeptide: meso-diaminopimelate ligase [Escherichia 172 3.70E-41 f752.aa gil2314673 (AE000648) UDP-MurNac-tripeptide synthetase (murE) [Helicobacter 137 9.80E-41 f752.aa gil840843 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase 135 1.70E-20 f76-1.aa gil1209837 lipoprotein [Borrelia burgdorferi] 395 2.80E-49 f76-1.aa gil1209873 lipoprotein [Borrelia burgdorferi] 250 7.00E-37 f76-1.aa gil1209843 lipoprotein [Borrelia burgdorferi] 267 7.30E-32 f76-1.aa gil2121280 (AF000270) lipoprotein [Borrelia burgdorferi] > gil3095109 258 1.20E-30 f76-1.aa gnl|PID|e26 surface-exposed lipoprotein [Borrelia afzelii] 116 2.40E-18 8244 f76-1.aa gil1209849 lipoprotein [Borrelia burgdorferi] 146 8.30E-17 f76-1.aa gil3095105 (AF046998) 2.9-8 lipoprotein [Borrelia burgdorferi] 148 5.80E-14 f76-1.aa gil3095107 (AF046999) 2.9-9 lipoprotein [Borrelia burgdorferi] 127 7.20E-11 f764.aa gil2688084 (AE001129) B. burgdorferi predicted coding region BB0193 [Borrelia 1218 1.20E-164 f770.aa gil2688077 (AE001129) conserved hypothetical protein [Borrelia burgdorferi] 646 7.60E-87 f790.aa gil2688065 (AE001128) outer membrane protein (tpn50) [Borrelia burgdorferi] 2013 2.50E-271 f790.aa gil458015 TpN50 precursor [Treponema pallidum] 134 4.30E-33 f790.aa sp|P38369|T OUTER MEMBRANE PROTEIN TPN50 PRECURSOR. 134 4.30E-33 P50_TREP A f790.aa gil532658 antigen [Treponema pallidum] > pir|S61867|S61867 antigen tpp57- 139 4.30E-31 f792.aa gil2688052 (AE001127) B. burgdorferi predicted coding region BB0165 [Borrelia 3185 0 f797.aa gil2688056 (AE001127) B. burgdorferi predicted coding region BB0159 [Borrelia 1116 5.30E-148 f798.aa gil2688051 (AE001127) antigen, S2, putative [Borrelia burgdorferi] 1223 9.70E-164 f798.aa gil1063419 S2 gene product [Borrelia burgdorferi] 116 4.70E-23 f798.aa gil2690227 (AE000790) antigen, S2 [Borrelia burgdorferi] > pir|D70207|D70207 116 1.50E-22 f798.aa gil2690128 (AE000788) protein p23 [Borrelia burgdorferi] > pir|C70257|C70257 110 1.40E-19 f798.aa gil2689956 (AE000785) protein p23 [Borrelia burgdorferi] > pir|D70225|D70225 104 2.70E-15 f799.aa gil2688043 (AE001126) B. burgdorferi predicted coding region BB0156 [Borrelia 632 1.40E-83 f8-10.aa gil2690052 (AE000784) antigen, P35, putative [Borrelia burgdorferi] 1241 1.10E-167 f8-10.aa gil2689955 (AE000785) antigen, P35, putative [Borrelia burgdorferi] 298 1.70E-57 f8-10.aa gil2690120 (AE000789) B. burgdorferi predicted coding region BBI34 [Borrelia 254 3.80E-54 f8-10.aa gil2690100 (AE000789) B. burgdorferi predicted coding region BBI16 [Borrelia 182 2.90E-31 f8-10.aa gil2690207 (AE000787) B. burgdorferi predicted coding region BBJ02 [Borrelia 196 1.50E-20 f8-10.aa gil2690116 (AE000789) B. burgdorferi predicted coding region BBI29 [Borrelia 192 5.50E-20 f8-10.aa gil2690125 (AE000788) antigen, P35, putative [Borrelia burgdorferi] 129 5.80E-14 f8-10.aa gil2690206 (AE000787) B. burgdorferi predicted coding region BBJ01 [Borrelia 103 1.10E-13 f8-10.aa gil2690099 (AE000789) B. burgdorferi predicted coding region BBI15 [Borrelia 142 8.50E-13 f8-10.aa gil2690115 (AE000789) B. burgdorferi predicted coding region BBI28 [Borrelia 130 3.30E-12 f8-14.aa gil2690074 (AE000784) B. burgdorferi predicted coding region BBH37 [Borrelia 1560 2.60E-206 f8-14.aa gil2690188 (AE000787) B. burgdorferi predicted coding region BBJ08 [Borrelia 599 3.50E-123 f8-14.aa gil2690030 (AE000786) B. burgdorferi predicted coding region BBG01 [Borrelia 337 4.40E-106 f8-14.aa gil2690139 (AE000788) B. burgdorferi predicted coding region BBK01 [Borrelia 173 8.00E-91 f8.aa gil2688783 (AE001182) B. burgdorferi predicted coding region BB0840 [Borrelia 2765 0 f8.aa gil2697112 (AF008219) unknown [Borrelia afzelii] 1494 2.80E-205 f800.aa gil2688044 (AE001126) B. burgdorferi predicted coding region BB0155 [Borrelia 1936 1.00E-262 f805.aa gil2688039 (AE001126) N-acetylglcosamine-6-phosphate deacetylase (nagA) 641 6.30E-85 f810.aa gil2688024 (AE001125) glycine betaine, L-proline ABC transporter, 1527 4.20E-207 f810.aa gil984805 glycine betaine-binding protein precursor [Bacillus subtilis] 179 6.80E-21 f810.aa gil1850605 ProX [Steptococcus mutans] 181 2.30E-18 f814.aa pir|D70117| acriflavine resistance protein (acrB) homolog - Lyme disease 5105 0 D70117 f814.aa gil2688027 (AE001125) acriflavine resistance protein (acrB) [Borrelia 5111 0 f814.aa gil2983346 (AE000707) cation efflux (AcrB/AcrD/AcrF family) [Aquifex aeolicus] 325 4.80E-119 f814.aa gil2313726 (AE000574) acriflavine resistance protein (acrB) [Helicobacter 327 4.50E-111 f814.aa gil3068786 (AF059041) RND pump protein [Helicobacter pylori] 297 1.70E-110 f814.aa gnl|PID|e11 similar to acriflavin resistance protein [Bacillus subtilis] 257 8.90E-100 82651 f814.aa gil1573914 acriflavine resistance protein (acrB) [Haemophilus influenzae] 294 2.10E-97 f814.aa gnl|PID|e25 mexF [Pseudomonas aeruginosa] 300 2.00E-88 6815 f814.aa gnl|PID|d10 cation efflux system protein CzcA [Synechocystis sp.] 198 1.30E-87 19295 f814.aa gnl|PID|e28 membrane-bound cation-proton-aniporter [Ralstonia eutropha] 283 2.20E-87 5274 f814.aa gil438854 envD homologue; ORFB [Pseudomonas aeruginosa] > pir|S39630|S39630 290 6.50E-87 f814.aa gnl|PID|d10 CzcA [Alcaligenes sp.] > pir|JC4700|JC4700 cadmium, zinc, 275 8.20E-87 11721 f814.aa gil2314107 (AE000605) cation efflux system protein (czcA) [Helicobacter 266 2.30E-86 f814.aa pir|A33830| cation efflux system membrane protein czcA - Alcaligenes 275 3.10E-86 A33830 f814.aa gnl|PID|d10 envD gene product homolog [Escherichia coli] > gil1788814 283 8.30E-86 17073 f818.aa gil2688032 (AE001125) B. burgdorferi predicted coding region BB0139 [Borrelia 664 3.00E-87 f82.aa gil2688729 (AE001177) B. burgdorferi predicted coding region BB0776 [Borrelia 991 2.20E-132 f820.aa gil2688029 (AE001125) penicillin-binding protein (pbp-1) [Borrelia 3171 0 f820.aa gil580936 SpoVD [Bacillus subtilis] > gnl|PID|e1185107 penicillin-binding 149 3.00E-49 f820.aa gil150283 penicillin-binding protein 2 [Neisseria meningitidis] 154 6.90E-43 f820.aa gnl|PID|e12 (AL022602) penicillin binding protein 2 [Mycobacterium 182 4.20E-42 87798 f820.aa gil509190 penicillin-binding protein 2 [Neisseria meningitidis] 158 1.70E-41 f820.aa gil509118 penicillin-binding protein 2 [Neisseria meningitidis] 151 7.10E-41 f820.aa gil840842 penicillin-binding protein 3 [Pseudomonas aeruginosa] 177 1.20E-40 f820.aa gil509065 penicillin-binding protein 2 [Neisseria meningitidis] 152 1.40E-40 f820.aa gil509043 penicillin-binding protein 2 [Neisseria meningitidis] 150 2.70E-40 f820.aa gil509159 penicillin-binding protein 2 [Neisseria meningitidis] 147 2.80E-40 f820.aa gil509120 penicillin-binding protein 2 [Neisseria meningitidis] 155 1.60E-39 f820.aa gil509157 penicillin-binding protein 2 [Neisseria meningitidis] 155 1.60E-39 f820.aa gil509126 penicillin-binding protein 2 [Neisseria meningitidis] 158 1.70E-39 f820.aa gil45178 penicillin-binding protein 2 (AA 1-581) [Neisseria meningitidis] 155 2.30E-38 f820.aa gil150279 penicillin-binding protein 2 [Neisseria gonorrhoeae] 154 8.70E-38 f831.aa gil2688018 (AE001124) B. burgdorferi predicted coding region BB0126 [Borrelia 994 1.20E-133 f843.aa gil2688014 (AE001124) PTS system, maltose and glucose-specific IIABC component 2590 0 f843.aa gil2688579 (AE001166) PTS system, glucose-specific IIBC component (ptsG) 594 1.80E-129 f843.aa gil1072418 glcA [Staphylococcus carnosus] > pir|S46952|S46952 283 1.00E-72 f843.aa gil1072419 glcB [Staphylococcus carnosus] > pir|S63606|S46953 248 1.00E-66 f843.aa dbjl|D86417 YflF [Bacillus subtilis] > gnl|PID|e1182760 similar to 215 7.90E-65 _11 f843.aa gil2197104 (AF003742) MalX homolog [Escherichia coli] 182 8.90E-64 f843.aa gil43819 nagE gene product [Klebiella pneumoniae] > pir|S18607|S18607 264 8.50E-63 f843.aa gil146913 N-acetylglucosamine transport protein ]Escherichia coli] 256 1.10E-62 f843.aa gil39956 IIGlc [Bacillus subtilis] > gnl|PID|e1184979 phosphotransferase system 315 5.20E-62 f843.aa dbjl|D87820 NagE [Vibrio cholerae non-O1] > pir|JC5651|JC5651 263 3.80E-61 _1 f843.aa gil2689888 (AE000792) PTS system, maltose and glucose-specific IIABC component 198 1.10E-60 f843.aa gil397363 enzyme II-glc [Salmonella typhimurium] > pir|S36620|S36620 227 1.20E-58 f843.aa gil147393 glucose-specific enzyme II of phosphotransferase system [Escherichia 226 3.90E-57 f843.aa gnl|PID|e11 alternate gene name: yzfA; similar to phosphotransferase 180 9.00E-56 82187 f843.aa gil1732194 PTS permease for glucose [Vibrio furnissii] 349 4.30E-50 f850.aa gil2687999 (AE001123) B. burgdorferi predicted coding region BB0110 [Borrelia 2374 0 f853.aa gil2687994 (AE001123) basic membrane protein [Borrelia burgdorferi] 1672 2.20E-224 f853.aa gil155055 basic membrane protein precursor [Treponema pallidum] 130 3.60E-24 f859.aa gil2688002 (AE001123) B. burgdorferi predicted coding region BB0102 [Borrelia 888 1.80E-115 f86.aa gil2688725 (AE001177) flagellar P-ring protein (flgI) [Borrelia burgdorferi] 1647 1.50E-217 f86.aa gil2920802 (AF019213) FlgI [Vibrio cholerae] 143 3.50E-14 f86.aa gil405550 flagellar P-ring protein [Pseudomonas putida] > sp|Q52082|FLGI_PSEPU 102 3.70E-13 f86.aa gil144241 flagellin [Caulobacter crescentus] > pir|A41891|A41891 basal body 110 6.70E-13 f860.aa gil2687998 (AE001123) asparaginyl-tRNA synthetas (asnS) [Borrelia 1110 2.40E-149 f860.aa gil1574761 asparaginyl-tRNA synthetase (asnS) [Haemophilus influenzae] 634 1.30E-83 f860.aa gil147935 asparaginyl-tRNA synthetase (asnS) [Escherichia coli] > gil41000 622 6.10E-82 f860.aa gnl|PID|e12 (AJ222644) asparaginyl-tRNA synthetase [Arabidopsis thaliana] 404 2.40E-80 02698 f860.aa gnl|PID|d10 asparaginyl-tRNA synthetase [Synechocystis sp.] 618 4.50E-80 11495 f860.aa gil530408 Asn-tRNA synthetase [Mycoplasma capricolum] > pir|S77842|S77842 439 1.60E-65 f860.aa gil1045792 asparaginyl-tRNA synthetase [Mycoplasma genitalium] 365 2.20E-62 f860.aa gil1674281 (AE000057) Mycoplasma pneumoniae, asparaginyl-tRNA synthetase; 338 3.10E-61 f860.aa gnl|PID|e12 (AJ222645) asparaginyl-tRNA synthetase [Arabidopsis thaliana] 364 3.90E-59 02700 f860.aa gnl|PID|e26 YCR245c, len:492 [Saccharomyces cerevisiae] > pir|S19435|S19435 150 3.90E-47 4488 f860.aa gnl|PID|e25 asparaginyl-tRNA synthetase [Salmonella typhi] 370 1.70E-46 4305 f860.aa gnl|PID|e18 asparagine--tRNA ligase [Lactobacillus delbrueckii] 224 1.30E-44 8505 f860.aa pir|S71072| asparagine--tRNA ligase (EC 6.1.122) asnS1 - Lactobacillus 224 1.30E-44 S71072 f860.aa gnl|PID|e18 asparagine--tRNA ligase [Lactobacillus delbrueckii] 224 2.40E-44 8572 f860.aa gil1146247 asparaginyl-tRNA synthetase [Bacillus subtilis] > gnl|PID|e1183681 234 6.10E-44 f861.aa gil2687975 (AE001122) glutamate racemase (murI) [Borrelia burgdorferi] 1354 2.90E-186 f861.aa gil396314 glutamate synthase [Escherichia coli] > gil290428 glutamate synthase 168 1.20E-16 f861.aa gnl|PID|e11 glutamate racemase [Bacillus subtilis] > gnl|PID|e1184088 120 1.80E-13 65353 f861.aa pir|JC5587| glutamate racemase (EC 5.1.1.3) - Bacillus pumilus 122 1.80E-13 JC5587 f861.aa sp|P52973| PROBABLE GLUTAMATE RACEMASE (EC 5.1.1.3) 114 8.10E-13 MURI_HA EIN f867.aa gil2687979 (AE001122) V-type ATPase, subunit A (atpA) [Borrelia burgdorferi] 2826 0 f867.aa pir|JC5532| vacuolar-type ATPase (EC 3.-.-.-) A chain - Desulurococcus 594 2.20E-162 JC5532 f867.aa gil2104726 V-ATPase A subunit [Desulfurococcus sp. SY] 594 3.10E-162 f867.aa gil2605627 ATPase alpha subunit [Thermococcus sp.] 592 7.10E-161 f867.aa gnl|PID|d10 Na+-ATPase alpha subunit [Enterococcus hirae] 601 1.60E-153 03475 f867.aa gil1590955 H+-transporting ATP synthase, subunit A (atpA) [Methanococcus 585 6.00E-147 f867.aa gil496904 membrane ATPase [Haloferax volcanii] > pir|S55895|S45144 728 6.00E-147 f867.aa gil152927 ATPase alpha subunit [Sulfolobus acidocaldarius] > pir|A28652|A28652 548 5.00E-163 f867.aa gil2649416 (AE001023) H+-transporting ATP synthase, subunit A (atpA) 748 2.00E-146 f867.aa gil2622052 (AE000869) ATP synthase, subunit A [Methanobacterium 607 9.40E-146 f867.aa gil168926 vacuolar ATPase vma-1 [Neurospora crassa] > pir|A30799|PXNCV7 302 9.00E-145 f867.aa gil149820 ATPase alpha subunit [Methanosarcina barkeri] > pir|A34283|A34283 743 1.40E-143 f867.aa gil160736 vacuolar ATPase [Plasmodium falciparum] > pir|A48582|A48582 vacuolar 305 9.40E-140 f867.aa gnl|PID|d10 adenosine triphosphatase A subunit [Acetabularia acetabulum] 307 9.00E-137 09732 f867.aa gil49048 ATPase alpha-subunit [Thermus aquaticus thermophilus] 684 4.80E-136 f868.aa gil2687980 (AE001122) V-type ATPase, subunit B (atpB) [Borrelia burgdorferi] 2205 1.80E-298 f868.aa gil1590954 H+-transporting ATP synthase, subunit B (atpB) [Methanococcus 156 2.00E-114 f868.aa gil2605628 ATPase beta subunit [Thermococcus sp.] 151 3.30E-108 f868.aa gil2104727 V-ATPase B subunit [Desulfurococcus sp. SY] 151 1.10E-107 f868.aa gil43641 ATP synthase subunit [Halobacterium salinarium] > pir|S14733|S14733 150 1.80E-107 f868.aa gil149821 ATPase beta subunit [Methanosarcina barkeri] > pir|B34283|B34283 172 1.00E-105 f868.aa gnl|PID|d10 Na+-ATPase beta subunit [Enterococcus hirae] 151 1.40E-105 03476 f868.aa gil2649415 (AE001023) H+-transporting ATP synthase, subunit B (atpB) 151 1.70E-103 f868.aa gil496905 membrane ATPase [Haloferax volcanii] > pir|S55896|S45145 153 5.80E-103 f868.aa gil1199639 AlAO H+ ATPase, subunit B [Methanosarcina mazeii] 173 2.20E-102 f868.aa gil2622051 (AE000869) ATP synthase, subunit B [Methyanobacterium 155 1.00E-101 f868.aa gnl|PID|d10 adenosine triphosphatase B subunit [Acetabularia acetabulum] 159 1.30E-101 09734 f868.aa gil1086645 Similar to vacuolar ATP synthase (strong). [Caenorhabditis elegans] 163 1.30E-101 f868.aa gil459198 vacuolar H+-ATPase subunit B [Gossypium hirsutum] 164 4.60E-101 f868.aa gil167108 vacuolar ATPase B subunit [Hordeum vulgare] 164 4.60E-101 > sp|Q40078|VAT1_HORVU f872.aa gil2687986 (AE001122) B. burgdorferi predicted coding region BB0089 [Borrelia 1684 1.60E-230 f874.aa gil2687965 (AE001121) L-lactate dehydrogenase (ldh) [Borrelia burgdorferi] 1603 2.80E-217 f874.aa gil39758 L-lactate dehydrogenase [Bacillus psychrosaccharolyticus] 520 3.10E-109 f874.aa pir|S08183| L-lactate dehydrogenase (EC 1.1.1.27) X - Bacillus 515 4.30E-109 S08183 f874.aa pir|A25805| L-lactate dehydrogenase (EC 1.1.1.27) - Bacillus subtilis 520 1.00E-107 A25805 f874.aa gil143136 L-lactate dehydrogenase [Bacillus megaterium] > pir|S00133|DEBSLM 430 5.20E-107 f874.aa gil143138 lactate dehydrogenase (EC 1.1.1.27) [Bacillus stearothermophilus] 514 6.60E-107 f874.aa gnl|PID|d10 L-lactate dehydrogenase [Bacillus subtilis] > gnl|PID|e1182257 512 8.90E-107 09574 f874.aa gil143134 lactate dehydrogenase (EC 1.1.1.27) [Bacillus caldotenax] 516 1.70E-106 f874.aa gil143132 lactate dehydrogenase (AC 1.1.1.27) [Bacillus caldolyticus] 506 2.30E-106 f874.aa gil412392 NAD-dependent dehydrogenase [unidentified] 508 4.40E-106 f874.aa gil143130 L-lactate dehydrogenase [Bacillus caldotenax] > pir|S00019|S00019 510 1.10E-105 f874.aa gil642256 L-lactate dehydrogenase [Pediococcus acidilactici] 560 1.70E-91 f874.aa gil847956 L-lactate dehydrogenase [Lactobacillus sake] > sp|P50934|LDH_LACSK 381 2.30E-91 f874.aa gil581305 L-lactate dehydrogenase [Lactobacillus plantarum] > pir|A36957|A36957 547 2.30E-91 f874.aa gil149575 L(+)-lactate dehydrogenase [Lactobacillus casei] 386 3.20E-91 f886.aa gil2687958 (AE001120) B. burgdorferi predicted coding region BB0077 [Borrelia 1792 9.50E-237 f888.aa gil2687959 (AE001120) B. burgdorferi predicted coding region BB0075 [Borrelia 2351 3.59999944710933e- 318 f893.aa gil2687962 (AE001120) B. burgdorferi predicted coding region BB0071 [Borrelia 2514 0 f895.aa gil2687954 (AE001120) conserved hypothetical protein [Borrelia burgdorferi] 747 3.60E-100 f895.aa gnl|PID|e11 similar to hypothetical proteins [Bacillus subtilis] 103 2.50E-35 84285 f899.aa gil2687946 (AE001119) B. burgdorferi predicted coding region BB0066 [Borrelia 1161 4.30E-158 f924.aa gil2687934 (AE001118) B. burgdorferi predicted coding region BB0044 [Borrelia 692 3.90E-93 f925.aa gil2687935 (AE001118) B. burgdorferi predicted coding region BB0043 [Borrelia 1771 7.50E-242 f929.aa gil2687916 (AE001117) B. burgdorferi predicted coding region BB0038 [Borrelia 2589 0 f93.aa gil2688703 (AE001176) pyridoxal kinase (pdxK) [Borrelia burgdorferi] 1334 6.60E-181 f933.aa gil2687917 (AE001117) B. burgdorferi predicted coding region BB0034 [Borrelia 902 1.90E-122 f933.aa gil2690091 (AE000789) conserved hypothetical protein [Borrelia burgdorferi] 136 3.10E-37 f933.aa gil2690225 (AS000790) conserved hypothetical protein [Borrelia burgdorferi] 149 4.50E-37 f933.aa gil2690045 (AE000784) conserved hypothetical protein [Borrelia burgdorferi] 126 5.70E-28 f933.aa gil2239281 No definition line found [Borrelia burgdorferi] 148 2.40E-14 f939.aa gil2687919 (AE001117) B. burgdorferi predicted coding region BB0028 [Borrelia 1796 7.50E-241 f940.aa gil2687920 (AE001117) B. burgdorferi predicted coding region BB0027 [Borrelia 1109 1.20E-152 f943.aa gil2687905 (AE001116) B. burgdorferi predicted coding region BB0024 [Borrelia 2001 5.00E-273 f943.aa gil411592 L-sorbosone dehydrogenase [unidentified] 175 2.30E-15 f943.aa gnl|PID|d10 L-sorbosone dehydrogenase [Acetobacter liquefaciens] 173 4.40E-15 06418 f952.aa gil2687880 (AE001115) glpE protein (glpE) [Borrelia burgdorferi] 628 2.90E-84 f07A.aa R33279 43 kD endoflagellum sheath protein 120 6.10E-25 f142.aa R95044 Apoptosis participating protein 103 4.70E-18 f147.aa W18209 Staphylococcus aureus Coenzyme A disulphide reductase (CoADR). 194 4.80E-91 f147.aa W06425 Water-forming NADH oxidase. 369 8.00E-86 f147.aa R32089 Benzene dioxygenase polypeptide V. 104 4.70E-11 f147.aa R66733 Aromatic dihydrodiol/catechol deoxygenase #5. 105 9.00E-11 f152.aa R81549 High affinity potassium uptake transporter HKT1. 137 3.70E-18 f157.aa W15192 Staphylococcus aureus cell surface protein. 239 3.40E-37 f17-6.aa W30763 Mannose-1-phosphate transferase protein MNN4. 178 5.20E-16 f17-6.aa W03627 Human follicle stimulating hormone GPR N-terminal sequence. 145 1.30E-11 f17-6.aa W03626 Human thyrotropin GPR N-terminal sequence. 144 1.90E-11 f17-6.aa W21591 Antibiotic potentiating peptide #3. 141 5.10E-11 f196.aa W05196 Helicobacter pylori 50 kDa protective antigen G3.8. 183 2.70E-18 f196.aa W20916 H. pylori inner membrane protein 14gp12015orf12. 180 3.60E-17 f196.aa W20287 H. pylori inner membrane protein, 24132293.aa 169 6.50E-15 f196.aa W20769 H. pylori inner membrane protein, 07ee20513orf28. 169 1.40E-14 f196.aa W20767 H. pylori cytoplasmic protein, 07ee20513orf1. 140 6.10E-14 f197.aa W20769 H. pylori inner membrane protein, 07ee20513orf28. 190 2.30E-19 f197.aa W20287 H. pylori inner membrane protein, 24132293.aa. 190 2.00E-18 f197.aa W05196 Helicobacter pylori 50 kDa protective antigen G3.8. 179 4.00E-16 f197.aa W20916 H. pylori inner membrane protein 14gp12015orf12. 182 6.30E-16 f197.aa W20767 H. pylori cytoplasmic protein, 07ee20513orf1. 150 1.10E-12 f21-4.aa R69629 B. burgdorferi OspF operon. 321 7.00E-39 f21-4.aa R89476 B. burgdorferi OspG lipoprotein. 107 6.10E-34 f24-1.aa W22676 Borrelia variable major protein (VMP)-like protein VlsE. 412 4.60E-72 f291.aa W20152 H. pylori transporter protein, 1464715.aa. 336 1.70E-41 f291.aa W24682 Helicobacter pylori transporter protein 4882763.aa. 234 8.20E-27 f291.aa W20528 H. pylori cell envelope transporter protein 4882763.aa. 234 8.20E-27 f291.aa W20592 H. pylori transporter protein, 01ce11513orf21. 168 7.60E-17 f301.aa W20287 H. pylori inner membrane protein, 24132293.aa. 158 1.60E-13 f301.aa W20916 H. pylori inner membrane protein 14gp12015orf12. 158 1.90E-13 f301.aa W20769 H. pylori inner membrane protein, 07ee20513orf28. 158 2.40E-13 f301.aa W05196 Helicobacter pylori 50 kDa protective antigen G3.8. 157 2.80E-13 f301.aa W20767 H. pylori cytoplasmic protein, 07ee20513orf1. 138 4.30E-11 f320.aa R24300 Glycopeptide resistance protein VanY from E. faecium. 142 2.90E-14 f328.aa R15642 CTP synthetase. 274 3.00E-50 f328.aa W20778 H. pylori cytoplasmic protein, 07ge20415orf6. 122 1.90E-34 f352.aa W03626 Human thyrotropin GPR N-terminal sequence. 153 4.70E-12 f352.aa W21591 Antibiotic potentiating peptide #3. 152 6.60E-12 f352.aa W03627 Human follicle stimulating hormone GPR N-terminal sequence. 145 5.30E-11 f4-50.aa W07187 B. garinii IP90 decorin binding protein. 305 1.30E-41 f4-50.aa W07186 B. afzelii strain pGau decorin binding protein. 161 1.60E-34 f4-50.aa W07185 B. burgdorferi HB-19 decorin binding protein. 173 2.80E-34 f4-50.aa W07183 B. burgdorferi B31 decorin binding protein. 176 1.80E-33 f4-50.aa W07190 B. burgdorferi JD1 decorin binding protein. 177 1.80E-33 f4-50.aa W07182 B. burgdorferi 297 decorin binding protein. 177 1.10E-32 f4-50.aa W07189 B. burgdorferi LP7 decorin binding protein. 177 1.10E-32 f4-50.aa W07188 B. burgdorferi LP4 decorin binding protein. 177 3.90E-32 f4-50.aa W07184 B. burgdorferi Sh.2.82 decorin binding protein. 177 1.30E-31 f45-2.aa R89476 B. burgdorferi OspG lipoprotein. 213 1.30E-35 f45-2.aa R70491 Leucocytozoan protozoa structural protein epitope. 206 2.10E-20 f45-2.aa W03626 Human thyrotropin GPR N-terminal sequence. 211 6.10E-20 f45-2.aa W03627 Human follicle stimulating hormone GPR N-terminal sequence. 202 8.90E-19 f45-2.aa R69629 B. burgdorferi OspF operon. 111 1.10E-14 f45-2.aa W30763 Mannose-1-phosphate transferase protein MNN4. 166 1.00E-13 f45-2.aa R97866 Chicken leucocytozoan immunogenic protein for use in vaccines. 154 7.10E-12 f488.aa W15078 M leprae gyrA precursor. 390 2.70E-143 f488.aa R88733 S. aureus mutant grlA protein. 698 6.70E-122 f488.aa R88731 S. aureus topoisomerase IV grlA subunit. 698 6.70E-122 f49-2.aa W22676 Borrelia variable major protein (VMP)-like protein VlsE. 497 2.70E-75 f5-14.aa W03626 Human thyrotropin GPR N-terminal sequence. 234 6.60E-23 f5-14.aa W03627 Human follicle stimulating hormone GPR N-terminal sequence. 231 1.40E-22 f5-14.aa R70491 Leucocytozoan protozoa structural protein epitope. 221 1.00E-20 f5-14.aa W30763 Mannose-1-phosphate transferase protein MNN4. 203 1.60E-18 f5-14.aa R97866 Chicken leucocytozoan immunogenic protein for use in vaccines. 187 2.10E-15 f5-14.aa W21591 Antibiotic potentiating peptide #3. 176 4.60E-15 f5-14.aa R69629 B. burgdorferi OspF operon. 106 3.50E-13 f5-14.aa R89476 B. burgdorferi OspG lipoprotein. 157 6.20E-13 f5-14.aa W26536 Trypanosoma cruzi antigen. 143 5.00E-11 f5-15.aa R69629 B. burgdorferi OspF operon. 448 1.30E-68 f5-15.aa R89476 B. burgdorferi OspG lipoprotein. 105 5.80E-24 f502.aa R69852 Ethylene response (ETR) mutant protein etr1-3. 191 1.90E-35 f502.aa R69849 Ethylene response (ETR) gene product. 191 2.70E-35 f502.aa R69853 Ethylene response (ETR) mutant protein etr1-4. 191 2.70E-35 f502.aa R69850 Ethylene response (ETR) mutant protein etr1-1. 191 3.60E-35 f502.aa R69851 Ethylene response (ETR) mutant protein etr1-2. 191 3.60E-35 f502.aa R74632 QETR ethylene response (ETR) protein from Arabidopsis thaliana. 190 5.20E-26 f502.aa R74629 Tornato ethylene response (TETR) protein. 171 6.50E-23 f502.aa R74633 Nr (never ripe) tomato ethylene response (ETR) protein. 171 6.50E-23 f502.aa R74630 Tornato TGETR1 ethylene response protein. 123 1.20E-19 f51-2.aa W03626 Human thyrotropin GPR N-terminal sequence. 235 2.90E-23 f51-2.aa R89476 B. burgdorferi OspG lipoprotein. 109 6.90E-23 f51-2.aa W03627 Human follicle stimulating hormone GPR N-terminal sequence. 228 2.20E-22 f51-2.aa W30763 Mannose-1-phosphate transferase protein MNN4. 203 1.00E-18 f51-2.aa R70491 Leucocytozoan protozoa structural protein epitope. 191 7.50E-18 f51-2.aa R97866 Chicken leucocytozoan immunogenic protein for use in vaccines. 183 4.80E-16 f51-2.aa W21591 Antibiotic potentiating peptide #3. 159 6.20E-13 f51-2.aa R68838 Plasmodium falciparum ABRA gene protein. 142 1.10E-12 f51-2.aa R27530 Plasmodium falciparum blood and liver stage ABRA antigen. 142 2.80E-12 f51-2.aa W31186 Human p160 polypeptide 160.2 148 2.30E-11 f51-2.aa W31185 Human p160 polypeptide 160.1 148 2.40E-11 f517.aa W24296 Staphylococcus aureus Gene #1 polypeptide sequence 2. 237 6.80E-30 f541.aa R31013 P39-alpha. 1253 3.80E-229 f541.aa R33280 P39-beta. 504 1.90E-117 f542.aa R33280 P39-beta. 711 3.20E-96 f542.aa R31013 P39-alpha. 101 7.90E-16 f561.aa R69631 B. burgdorferi T5 protein. 982 6.90E-131 f598.aa W20289 H. pylori transporter protein, 24218968.aa. 264 9.90E-33 f598.aa W20640 H. pylori transporter protein, 02ce11022orf8. 264 1.00E-30 f598.aa W20101 H. pylori transporter protein 11132778.aa. 233 8.50E-27 f598.aa W20861 H. pylori cell envelope transporter protein, 12ge10305orf16. 233 9.60E-27 f598.aa W34202 Streptomyces efflux pump protein (frenolicin gene D product). 196 2.80E-21 f598.aa R71091 C. jejuni PEB1A antigen from ORF3. 168 1.20E-17 f600.aa W25527 Staphlococcus aureus Gene #20 polypeptide sequence 2. 209 3.40E-26 f600.aa W34201 Streptomyces efflux pump protein (frenolicin gene C product). 169 6.50E-19 f600.aa W20639 H. pylori transporter protein, 02ce11022orf7. 127 1.10E-14 f603.aa W34200 Streptomyces efflux pump protein (frenolicin gene B product). 155 7.40E-32 f604.aa R48035 Hyaluronic acid synthase of Streptococcus equisimilis. 110 2.30E-20 f606.aa R48035 Hyaluronic acid synthase of Streptococcus equisimilis. 116 1.20E-25 f607.aa R48035 Hyaluronic acid synthase of Streptococcus equisimilis. 141 1.50E-26 f631.aa W15192 Staphylococcus aureus cell surface protein. 160 7.30E-29 f664.aa W20105 H. pylori flagella-associated protein, 1171928.aa. 202 3.20E-46 f664.aa W20688 H. pylori flagella-associated protein 04ge11713orf5. 202 2.60E-45 f664.aa R97245 Virulence gene cluster polypeptide product. 158 3.90E-13 f704.aa R60153 Nematode-inducible transmembrane pore protein. 104 2.50E-18 f704.aa R33913 Sequence encoded by TobRB7-5A which encodes a membrane channel 104 2.50E-18 f704.aa R77082 Tobacco root specific promoter RB7 from clone lambda5A (TobRB7-5A). 104 2.50E-18 f742.aa W46499 Amino acid sequence of the spindly (SPY) protein of Arabidopsis. 101 2.50E-14 f752.aa W20733 H. pylori cell envelope protein, 06cp11722orf15. 141 3.00E-37 f752.aa W20358 H. pylori cell envelope protein 26366312.aa. 110 4.20E-18 f814.aa W20753 H. pylori transporter protein, 06gp11202orf7. 178 7.90E-35 f814.aa W20420 H. pylori cell envelope transporter protein 33399142.aa. 160 2.30E-21 f843.aa R14319 Human T-cell immunosuppressive factor. 167 1.20E-19 f860.aa W21894 Asparaginyl-tRNA synthetase from Staphylococcus aureus. 245 2.30E-38 f860.aa W33903 Streptococcus pneumoniae asparaginyl tRNA synthetase. 177 1.10E-22 f867.aa W34261 An alpha subunit of a thermostable ATPase. 592 1.30E-161 f867.aa R10098 Alpha subunit of ATP-synthase. 741 4.90E-144 f867.aa R31522 Carrot reverse transcriptase. 311 4.60E-130 f867.aa R10099 Beta subunit of ATP-synthase. 121 7.90E-14 f867.aa W34262 A beta subunit of a thermostable ATPase. 116 1.00E-12 f868.aa W34262 A beta subunit of a thermostable ATPase. 151 6.10E-109 f868.aa R10099 Beta subunit of ATP-synthase. 172 1.90E-106 f868.aa W34261 An alpha subunit of a thermostable ATPase. 117 3.10E-19 f868.aa R10098 Alpha subunit of ATP-synthase. 113 2.00E-18 f868.aa R31522 Carrot reverse transcriptase. 101 7.10E-15 f874.aa R10591 L-lactic acid dehydrogenase. 538 7.20E-109 f874.aa R08355 Recombinant thermophilic NAD-dependant dehydrogenase. 455 9.80E-99 f874.aa R09295 Recombinant thermophilic NAD-dependant dehydrogenase. 455 9.80E-99 f874.aa R15736 L-lactic acid dehydrogenase. 426 1.60E-85 f874.aa P91948 Pig H4 isoenzyme. 393 2.00E-82 f874.aa W33108 Chicken lactic acid dehydrogenase type B subunit. 390 2.20E-80 f874.aa W33107 Chicken lactic acid dehydrogenase type B subunit. 385 1.10E-79 f874.aa P80891 Testis-specific lactate dehydrogenase subunit LDH-C4. 339 5.50E-74 f874.aa R94013 Heat resistant maleate dehydrogenase. 255 1.30E-55 f874.aa R11119 Recombinant L-2-hydroxyisocaproic acid dehydrogenase. 224 7.90E-49 f874.aa R62605 P. falciparum lactate dehydrogenase. 255 2.00E-44 f874.aa W11476 Eimeria lactate dehydrogenase. 203 1.10E-25 f943.aa P91223 Coenzyme-independent L-sorbosone dehydrogenase from Gluconobacter 175 4.30E-16

TABLE 3 Conservative Amino Acid Substitutions. Aromatic Phenylalanine Tryptophan Tyrosine Hydrophobic Leucine Isoleucine Valine Polar Glutamine Asparagine Basic Arginine Lysine Histidine Acidic Aspartic Acid Glutamic Acid Small Alanine Serine Threonine Methionine Glycine

TABLE 4 Residues Comprising Epito-Bearing Fragments Query Residues Comprising Epito-Bearing Fragments f101.aa from about Lys-62 to about Gly-64, from about Ser-111 to about Asp-113, from about Arg-136 to about Arg-139, from about Pro- 189 to about Asn-193. f11.aa from about Pro-38 to about Lys-40, from about Glu-92 to about Lys-96. f12.aa from about Pro-288 to about Asp-290, from about Asn-336 to about Gly-338, from about Tyr-410 to about Gly-413, from about Asp-418 to about Arg-420, from about Pro-552 to about Val-555, from about Gln-643 to about Asp-645, from about Gln-1061 to about Arg-1063, from about Asn-1130 to about Lys-1132. f129.aa from about Glu-76 to about Arg-81, from about Lys-144 to about Asn-146. f147.aa from about Gln-94 to about Thr-96. f152.aa from about Gly-35 to about Gly-37, from about Gln-321 to about Gly-323. f154.aa from about Asn-39 to about Lys-41, from about Ser-74 to about Lys-77, from about Ser-213 to about Gly-215, from about Ser-303 to about Asp-306, from about Asp-422 to about Asn-424. f157.aa from about Lys-21 to about Asp-24, from about Ser-45 to about Tyr-47. f17.aa from about Arg-17 to about Asn-20, from about Thr-94 to about Gly-96. f186.aa from about Lys-305 to about Tyr-308. f196.aa from about Lys-121 to about Asn-123, from about Pro-278 to about Lys-282, from about Glu-576 to about Tyr-578. f899.aa from about Asn-174 to about Asp-177. f925.aa from about Lys-201 to about Asp-204, from about Phe-291 to about Lys-294. f929.aa from about Pro-139 to about Asn-141, from about Arg-211 to about Glu-214, from about Thr-370 to about Asn-375. f933.aa from about Ser-139 to about Lys-143. f940.aa from about Gly-143 to about Asn-148. f943.aa from about Asp-58 to about Asp-60, from about Lys-157 to about Asn-159, from about Asp-217 to about Asp-221, from about Lys-250 to about Asn-254, from about Pro-262 to about Asn-264, from about Gly-305 to about Trp-307. f952.aa from about Ser-52 to about Ser-54. f4.aa from about Arg-64 to about Arg-67. f43.aa from about Ser-84 to about Gln-87, from about Asp-231 to about Tyr-233, from about Arg-296 to about Asp-300. f50.aa from about Glu-136 to about Gly-138, from about Asp-153 to about Lys-155, from about Asp-289 to about Asp-291, from about Glu-458 to about Asn-461. f65.aa from about Glu-120 to about Asp-122, from about Pro-204 to about Tyr-206. f8.aa from about Pro-263 to about Arg-265, from about Asp-274 to about Lys-278. f82.aa from about Tyr-66 to about Gly-68, from about Ser-116 to about Lys-119, from about Asp-121 to about Gly-123, from about Pro- 128 to about Gly-131. f86.aa from about Asn-179 to about Asn-181, from about Lys-192 to about Asn-194, from about Lys-270 to about Asn-272, from about Lys-279 to about Lys-282, from about Asp-331 to about Asn-333. f477.aa from about Pro-250 to about Lys-253. f488.aa from about Lys-76 to about Lys-79, from about Asn-486 to about Asp-489, from about Lys-508 to about Gly-510, from about Asn-559 to about Gly-562. f494.aa from about Lys-76 to about Asn-78. f516.aa from about Lys-32 to about Asp-34. f523.aa from about Pro-202 to about Asn-206, from about Lys-255 to about Tyr-258. f526.aa from about Asn-85 to about Lys-88, from about Asp-136 to about Gly-138. f577.aa from about Cys-18 to about Lys-22, from about Asn-297 to about Gln-300. f584.aa from about Pro-131 to about Lys-133, from about Pro-200 to about Ser-202. f596.aa from about Arg-42 to about Asp-44, from about Asp-117 to about Tyr-119, from about Pro-205 to about Asp-207. f600.aa from about Pro-143 to about Asp-145. f603.aa from about Phe-35 to about Ser-37. f607.aa from about Gln-67 is about Lys-70, from about Asp-273 to about Tyr-275, from about Asp-333 to about Gly-338, from about Pro- 359 to about Lys-362, from about Arg-409 to about Gly-411. f611.aa from about Arg-133 to about Gly-135. f631.aa from about Pro-132 to about Asn-136, from about Asn-159 to about Tyr-161, from about Pro-216 to about Asp-218, from about Pro-220 to about Lys-223. f688.aa from about Lys-266 to about Asp-268, from about Lys-271 to about Asn-273, from about Lys-315 to about Lys-318. f704.aa from about Lys-250 to about Lys-253. f707.aa from about Lys-131 to about Asp-134, from about Asp-246 to about Asn-249. f709.aa from about Tyr-39 to about Gly-42, from about Lys-148 to about Gly-150, from about Arg-269 to about Gly-272, from about Ser- 466 to about Tyr-468, from about Asn-489 to about Asn-491, from about Lys-575 to about Asp-578, from about Pro-642 to about Lys-644. f197.aa from about Pro-217 to about Asp-219, from about Glu-675 to about Asp-678, from about Pro-687 to about Asn-689, from about Glu-694 to about Gln-696. f200.aa from about Arg-174 to about Phe-179. f208.aa from about Arg-326 to about Ser-328. f210.aa from about Pro-191 to about Ile-194. f221.aa from about Asn-133 to about Asn-135. f253.aa from about Arg-191 to about Gly-194. f269.aa from about Ser-271 to about Thr-273, from about Asp-284 to about Gly-286. f29.aa from about Pro-159 to about Ser-161. f290.aa from about Pro-240 to about Gly-244. f291.aa from about Gln-267 to about Lys-269. f296.aa from about Glu-98 to about Lys-101. f3.aa from about Asn-241 to about Lys-245. f30.aa from about Asn-156 to about Tyr-159, from about Asn-178 to about Lys-180. f939.aa from about Ser-245 to about Asn-249. f739.aa from about Asn-80 to about Tyr-82, from about Lys-208 to about Ser-210. f742.aa from about Ser-141 to about Asp-145, from about Asn-222 to about Gln-225, from about Asp-243 to about Tyr-247, from about Asn-249 to about Asn-251. f743.aa from about Arg-111 to about Gly-114, from about Pro-131 to about Asp-134. f790.aa from about Thr-40 to about Asn-42, from about Ser-53 to about Ser-55, from about Lys-215 to about Asp-218, from about Asn-274 to about Gly-277. f792.aa from about Val-82 to about Ser-84, from about Ser-102 to about Asn-104, from about Gln-127 to about Tyr-130, from about Lys- 309 to about Asn-314, from about Lys-375 to about Thr-377, from about Pro-511 to about His-513, from about Thr-515 to about Asp-517. f797.aa from about Pro-119 to about Gly-122, from about Lys-166 to about Asn-169. f799.aa from about Asn-31 to about Asn-34, from about Gln-44 to about Asn-47, from about Pro-123 to about Gly-125. f814.aa from about Ser-120 to about Ser-122, from about Arg-636 to about Asn-638, from about Cys-967 to about Ser-969. f820.aa from about Thr-563 to about Tyr-565. f850.aa from about Tyr-159 to about Tyr-164, from about Gln-375 to about Asp-379. f853.aa from about Thr-180 to about Lys-184, from about Arg-231 to about Asp-233, from about Asn-252 to about Gly-254. f859.aa from about Lys-46 to about Ser-52, from about Pro-88 to about Asn-91, from about Asn-117 to about Asp-120. f861.aa from about Asp-38 to about Lys-40, from about Lys-219 to about Asn-225. f368.aa from about Gln-228 to about Asn-231. f371.aa from about Tyr-109 to about Asn-111, from about Asn-162 to about Gln-164. f502.aa from about Asn-118 to about Lys-122, from about Ser-269 to about Gly-271, from about Lys-370 to about Asp-373, from about Asn-509 to about Lys-511, from about Lys-705 to about Arg-707, from about Thr-912 to about Gly-914, from about Pro-1213 to about Asp-1216, from about Asn-1491 to about Arg-1493. f527.aa from about Cys-20 to about Gln-22, from about Asn-38 to about Asn-40, from about Phe-112 to about Asp-114, from about Lys-160 to about Asn-162, from about Ser-199 to about Asp-201, from about Gln-258 to about Gly-261, from about Arg-282 to about Asn-284, from about Ser-297 to about Asp-299. f541.aa from about Ser-68 to about Asn-71. f604.aa from about Lys-77 to about Gly-79, from about Lys-201 to about Asn-203, from about Asp-252 to about Asp-254, from about Tyr-347 to about Gly-350, from about Asp-514 to about Trp-516. f736.aa from about Lys-20 to about Asn-24, from about Arg-147 to about Ser-153, from about Ser-231 to about Lys-233. f752.aa from about Thr-119 to about Lys-122, from about Pro-420 to about Gly-422. f798.aa from about Asp-33 to about Thr-36, from about Lys-180 to about His-183. f635.aa from about Pro-100 to about Asn-102, from about Asp-145 to about Phe-147. f32.aa from about Lys-18 to about Asn-20. f320.aa from about Asn-193 to about Leu-195, from about Gln-248 to about Lys-250. f352.aa from about Ser-46 to about Asn-49. f301.aa from about Lys-178 to about Lys-180, from about Ser-401 to about Tyr-404. f373.aa from about Gly-88 to about Lys-90, from about Asn-539 to about Lys-542, from about Glu-654 to about Ser-657. f384.aa from about Pro-250 to about Asn-252, from about Asp-266 to about Lys-268. f446.aa from about Asp-20 to about Ser-26, from about Asn-146 to about Lys-149. f542.aa from about Arg-86 to about Gly-88, from about Arg-163 to about Asn-165. f93.aa from about Asn-152 to about Asp-155. f105.aa from about Asp-48 to about Phe-50. f150.aa from about Thr-214 to about Asp-218, from about Asp-256 to about Asp-259. f219.aa from about Asn-77 to about Asn-81, from about Asp-111 to about Asn-115. f229.aa from about Gln-61 to about Asn-63. f32.aa from about Lys-18 to about Asn-20. f186.aa from about Lys-305 to about Tyr-308. f216.aa from about Ser-105 to about Asn-107. f328.aa from about Asn-105 to about Asp-107. f352.aa from about Ser-46 to about Asn-49. f867.aa from about Thr-3 to about Gly-5, from about Lys-156 to about Ser-159. f868.aa from about Arg-94 to about Gly-96, from about Pro-257 to about Gly-261, from about Pro-295 to about Asp-297, from about Arg- 340 to about Asp-342. f872.aa from about Ser-19 to about Lys-23, from about Thr-139 to about Asp-142, from about Ser-282 to about Tyr-286, from about Ser-311 to about Ser-313. f886.aa from about Thr-83 to about Asp-85, from about Asp-106 to about Lys-108, from about Lys-143 to about Gly-147, from about Asp-186 to about Asn-191. f888.aa from about Asn-65 to about Asp-67. f893.aa from about Asn-203 to about Asn-207, from about Thr-446 to about Asn-450. f605.aa from about Arg-31 to about Asp-33. f606.aa from about Asn-68 to about Gly-71, from about Asn-136 to about Lys-139, from about Asn-223 to about Tyr-226, from about Ser-276 to about Tyr-279, from about Pro-362 to about Asn-365, from about Arg-503 to about Trp-507. f679.aa from about Lys-154 to about Asp-156, from about Lys-224 to about Arg-226, from about Asn-260 to about Asp-264, from about Glu-363 to about Lys-366, from about Asp-387 to about Gly-389, from about Tyr-441 to about Lys-443, from about Arg-501 to about Tyr-504. f11- from about Pro-91 to about Asn-93, from about Pro-181 to 12.aa about Asp-186, from about Lys-244 to about Ser-248. f11-4.aa from about Asn-160 to about Lys-163. f14-8.aa from about Pro-92 to about Gln-95, from about Lys-123 to about Thr-125, from about Lys-215 to about Asp-219. f17-6.aa from about Pro-36 to about Glu-38. f19-2.aa from about Ser-104 to about Ser-106, from about Gln-230 to about Asn-232. f19-4.aa from about Val-79 to about Thr-82, from about Pro-195 to about Gly-201. f19-6.aa from about Asp-24 to about Lys-30, from about Pro-36 to about Glu-38. f21-4.aa from about Cys-24 to about Asn-26. f28-2.aa from about Ser-77 to about Lys-80, from about Tyr-274 to about Asn-277. f28-3.aa from about Glu-53 to about Arg-57, from about Gln-82 to about Asn-85, from about Gln-157 to about Asn-159. f31-2.aa from about Arg-95 to about Arg-97, from about Asn-297 to about Asn-299. f4-15.aa from about Pro-182 to about Asp-184, from about Lys-220 to about Asp-222. f4-50.aa from about Thr-109 to about Asn-111. f42-1.aa from about Asn-55 to about Asn-57, from about Arg-81 to about Ser-84, from about Asp-94 to about Asn-97. f45-2.aa from about Asn-83 to about Gly-86. f47-2.aa from about Ser-29 to about Asp-33, from about Asn-94 to about Lys-99, from about Pro-152 to about Lys-157. f49-2.aa from about Asn-452 to about Gly-454. f5-14.aa from about Glu-102 to about Asp-106, from about Thr-272 to about Asn-275, from about Glu-313 to about Asn-315, from about Ser-370 to about Ser-372. f5-15.aa from about Lys-170 to about Gly-173, from about Asn-194 to about Gly-196. f51-2.aa from about Asp-302 to about Lys-304. f6-21.aa from about Glu-38 to about Asn-42, from about Arg-84 to about Gly-87. f6-27.aa from about Asp-67 to about Asn-69, from about Arg-85 to about Asn-89, from about Lys-168 to about Gly-171, from about Lys-179 to about Asn-181, from about Ser-380 to about His-382. f6-5.aa from about Ser-67 to about Asn-71. f7-30.aa from about Pro-94 to about Asp-96, from about Lys-144 to about Arg-147. f76-1.aa from about Asn-30 to about Lys-35, from about Lys-113 to about Gly-116, from about Glu-119 to about Lys-121. f8-10.aa from about Pro-25 to about Lys-32, from about Ser-168 to about Thr-172. f01a. from about Pro-123 to about Asp-125, from about Ser-179 to aa_(—) about Asp-181, from about Lys-255 to about Gly-259. bb001 _(—) from about Ala8 about Arg 17, from about Tyr31 to about bb0011 Gly40, from about Ser65 to about Lys78, from about Val93 to about Asp102, from about Ser120 to about Ile129, from about Pro156 to about Glu170, from about Lys187 to about Asn 196, from about His205 to about Lys214, from about Gly226 to about Glu235, from about Gln253 to about Asn266, from about Glu283 to about Glu293, from about Leu311 to about Ile320, from about Arg326 to about Gly335, from about Pro340 to about Ala349 f02a.aa from about Tyr-169 to about Asn-171, from about Tyr-242 to _bb002 about Asn-245, from about Lys-264 to about Asp-267. _bb9 from about Met7 to about Lys16, from about Lys47 to about Ser57, from about Asn80 to about Ser89, from about Gly 103 to about Glu113, from about Lys125 to about Pro133, from about Lys138 to about Ala147 f03a.aa from about Asp-54 to about Thr-57, from about Lys-201 to _(—) about His-204. bb006 _bb014 from about Pro23 to about Gln31, from about Ser37 to about Asp45, from about Leu76 to about Asn84, from about Leu76 to about Val84, from about Ser89 to about Asn97, from about Ser105 to about Lys113, from about Asn120 to about Met128, from about Asn159 to about Gly 167, from about Lys173 to about Bal181 _bb023 from about Asp17 to about Gly27, from about Arg40 to about Asp48, from about Val64 to about Asp72, from about Glu105 to about Thr113, from about Ser141 to about Gly150, from about Asp155 to about Ile163, from about Asn184 to about Lys198, from about Ile219 to about Pro227, from about Ser230 to about Phe238, from about Ser241 to about Asn250, from about Asp270 to about Val278, from about Ser285 to about Leu293, from about Glyu307 to about Ser315, from about Lys327 to about Asn335 f08a.aa from about Asn-30 to about Asp-33, from about Ser-116 to _(—) about Asn-118, from about Asn-154 to about Gly-156. bb024 f09a.aa from about Asn-30 to about Ser-35, from about Thr-145 to about _(—) Asn-148. bb025 

1. An isolated polynucleotide which encodes at least 50 contiguous amino acid residues of SEQ ID NO:627.
 2. The isolated polynucleotide which is fully complementary to the polynucleotide of claim
 1. 3. An isolated polynucleotide consisting of at least 100 contiguous nucleotides of SEQ ID NO:625.
 4. The isolated polynucleotide which is fully complementary to the polynucleotide of claim
 3. 5. The isolated polynucleotide of claim 3 consisting of at least 300 contiguous nucleotides of SEQ ID NO:625.
 6. The isolated polynucleotide which is fully complementary to the polynucleotide of claim
 5. 7. The isolated polynucleotide of claim 5 consisting of the full length sequence of SEQ ID NO:625.
 8. A method of detecting Borrelia nucleic acids in a biological sample comprising: (a) contacting the sample with the nucleic acid of claim 1, under conditions such that hybridization occurs, and (b) detecting hybridization of said nucleic acids to the one or more Borrelia nucleic acid sequences present in the biological sample.
 9. A method of detecting Borrelia nucleic acids in a biological sample comprising: (a) contacting the sample with the nucleic acid of claim 3, under conditions such that hybridization occurs, and (b) detecting hybridization of said nucleic acids to the one or more Borrelia nucleic acid sequences present in the biological sample. 